sb 203580 has been researched along with y 27632 in 25 studies
| Studies (sb 203580) | Trials (sb 203580) | Recent Studies (post-2010) (sb 203580) | Studies (y 27632) | Trials (y 27632) | Recent Studies (post-2010) (y 27632) |
|---|---|---|---|---|---|
| 3,489 | 4 | 1,137 | 1,924 | 3 | 891 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 14 (56.00) | 29.6817 |
| 2010's | 11 (44.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caivano, M; Cohen, P; Davies, SP; Reddy, H | 1 |
| McGovern, SL; Shoichet, BK | 1 |
| Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H | 1 |
| Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N | 1 |
| Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M | 1 |
| Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A | 1 |
| Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ | 1 |
| Basdra, EK; Kletsas, D; Papavassiliou, AG | 1 |
| Aspenström, P; Edlund, S; Heldin, CH; Landström, M | 1 |
| Hirano, K; Kanaide, H; Maeda, Y; Nishimura, J; Sasaki, T | 1 |
| Dubroca, C; Henrion, D; Lévy, BI; Loufrani, L; You, D | 1 |
| Itoh, K; Lin, M; van Golen, KL; Yee, D; Yoshioka, K; Zhang, X | 1 |
| Brown, DL; Kohama, K; Kumagai, H; Li, S; Nakamura, A; Tanaka, H; Thatcher, SE; Wang, HH; Wright, GL; Yoshiyama, S | 1 |
| Adyshev, D; Bogatcheva, NV; Mambetsariev, B; Moldobaeva, N; Verin, AD | 1 |
| Chen, JW; Chen, YH; Chen, YL; Hsieh, LY; Ku, HH; Lin, CY; Lin, FY; Lin, SJ; Wang, SH; Wang, YC | 1 |
| Bachem, MG; Gross, HJ; Li, Y; Schmelz, A; Seufferlein, T; Zhou, S | 1 |
| Abdel-Tawab, H; Ahmed, EA; Alhazza, IM; Badr, G; Hassan, K; Saad, H; Waly, H | 1 |
| Chen, B; Du, J; Guo, X; Huang, Q; Huang, X; Li, Q; Liu, H | 1 |
| Adyshev, DM; Dudek, SM; Elangovan, VR; Garcia, JG; Moldobaeva, NK | 1 |
| Abo, Y; Ichikawa, H; Nakata, N; Sasaki, K; Shirasawa, S; Tomotsune, D; Yokoyama, T; Yoshie, S; Yue, F | 1 |
| Dou, Y; Gao, C; Guo, F; Huan, J; Tang, J; Xing, Y; Zhou, Z | 1 |
| Andrews, MA; Austin, M; Ibe, BO; Lazaro, M; Lustina, J; Raj, JU; Renteria, LS | 1 |
| Ju, Y; Song, G; Xu, B | 1 |
| Cui, Y; Fang, Y; Gao, Y; Kohama, K; Lin, HS; Qin, YH; Su, WM; Sun, YW; Wei, XQ; Zhao, Y | 1 |
| Doi, T; Enomoto, Y; Iida, H; Iida, Y; Iwama, T; Kozawa, O; Kuroyanagi, G; Matsushima-Nishiwaki, R; Ogura, S; Otsuka, T; Tanabe, K; Tokuda, H; Tsujimoto, M; Yamamoto, N | 1 |
25 other study(ies) available for sb 203580 and y 27632
| Article | Year |
|---|---|
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides | 2000 |
Kinase inhibitors: not just for kinases anymore.
Topics: beta-Lactamase Inhibitors; beta-Lactamases; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Biological; Phosphotransferases; Scattering, Radiation | 2003 |
Identifying off-target effects and hidden phenotypes of drugs in human cells.
Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship | 2006 |
The selectivity of protein kinase inhibitors: a further update.
Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera | 2007 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2007 |
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase | 2013 |
Identification of potent Yes1 kinase inhibitors using a library screening approach.
Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship | 2013 |
Effect of protein kinase inhibitors on the stretch-elicited c-Fos and c-Jun up-regulation in human PDL osteoblast-like cells.
Topics: Amides; Carrier Proteins; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyridines; rho-Associated Kinases; Stress, Mechanical; Up-Regulation | 2002 |
Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA.
Topics: Actins; Amides; Animals; cdc42 GTP-Binding Protein; Cell Surface Extensions; Cytoskeleton; DNA-Binding Proteins; Enzyme Inhibitors; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; rac1 GTP-Binding Protein; Rats; Recombinant Fusion Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Smad4 Protein; Stress Fibers; Trans-Activators; Transforming Growth Factor beta; Tumor Cells, Cultured | 2002 |
Endothelial dysfunction and altered bradykinin response due to oxidative stress induced by serum deprivation in the bovine cerebral artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Ascorbic Acid; Bradykinin; Cattle; Cerebral Arteries; Chromones; Culture Media; Culture Media, Serum-Free; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Genistein; Imidazoles; In Vitro Techniques; Indoles; Maleimides; Morpholines; Oxidative Stress; Potassium; Protein Kinase Inhibitors; Pyridines; Serum; Superoxide Dismutase; Time Factors; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2004 |
Involvement of RhoA/Rho kinase pathway in myogenic tone in the rabbit facial vein.
Topics: Amides; Animals; Biological Transport; Cell Membrane; Enzyme Inhibitors; Face; Heat-Shock Proteins; Imidazoles; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Physical Stimulation; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; rhoA GTP-Binding Protein; Temperature; Vasoconstriction; Veins | 2005 |
Multiple signaling pathways are activated during insulin-like growth factor-I (IGF-I) stimulated breast cancer cell migration.
Topics: Amides; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Enzyme Inhibitors; Female; Focal Adhesion Kinase 1; Humans; Imidazoles; Immunoblotting; Insulin-Like Growth Factor I; Microscopy, Confocal; Mitogen-Activated Protein Kinase Kinases; Pyridines; rho GTP-Binding Proteins; Signal Transduction | 2005 |
Intracellular signal transduction for migration and actin remodeling in vascular smooth muscle cells after sphingosylphosphorylcholine stimulation.
Topics: Actins; Amides; Animals; Azepines; Cell Movement; Cells, Cultured; Cytoskeleton; Enzyme Inhibitors; GTP-Binding Proteins; Guinea Pigs; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth, Vascular; Myosin Light Chains; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Phosphorylcholine; Pyridines; Signal Transduction; Sphingosine | 2006 |
Involvement of microtubules, p38, and Rho kinases pathway in 2-methoxyestradiol-induced lung vascular barrier dysfunction.
Topics: 2-Methoxyestradiol; Actomyosin; Amides; Blood-Air Barrier; Cell Membrane Permeability; Endothelial Cells; Estradiol; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Microelectrodes; Microtubules; Models, Biological; Myosin-Light-Chain Kinase; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Phosphorylation; Protein Serine-Threonine Kinases; Pulmonary Artery; Pyridines; rho-Associated Kinases; Tubulin | 2007 |
Pravastatin induces thrombomodulin expression in TNFalpha-treated human aortic endothelial cells by inhibiting Rac1 and Cdc42 translocation and activity.
Topics: Amides; Anthracenes; Aorta; Blotting, Western; Boron Compounds; cdc42 GTP-Binding Protein; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Endothelial Cells; Enzyme Activation; Flavonoids; Humans; Imidazoles; Leucine; Mitogen-Activated Protein Kinases; Phosphorylation; Pravastatin; Protein Transport; Pyridines; rac1 GTP-Binding Protein; Thrombomodulin; Time Factors; Tumor Necrosis Factor-alpha | 2007 |
Low intensity pulsed ultrasound accelerates macrophage phagocytosis by a pathway that requires actin polymerization, Rho, and Src/MAPKs activity.
Topics: Actins; Amides; Animals; Cell Line; Cells, Cultured; Complement Activation; Cytochalasin D; Escherichia coli; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; Macrophages; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phagocytosis; Protein Kinase Inhibitors; Pyridines; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; src-Family Kinases; Time Factors; Ultrasonics | 2008 |
Type I interferon (IFN-alpha/beta) rescues B-lymphocytes from apoptosis via PI3Kdelta/Akt, Rho-A, NFkappaB and Bcl-2/Bcl(XL).
Topics: Adenine; Amides; Animals; Antibodies, Blocking; Apoptosis; B-Lymphocytes; bcl-X Protein; Cells, Cultured; Class I Phosphatidylinositol 3-Kinases; Gene Expression Regulation; Humans; Imidazoles; Immunologic Memory; Interferon Type I; Lymphocyte Subsets; Mice; NF-kappa B; Oncogene Protein v-akt; Peptides; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyridines; Quinazolines; Receptors, Interferon; Recombinant Proteins; rho-Associated Kinases; Signal Transduction | 2010 |
Advanced glycation end products induce moesin phosphorylation in murine brain endothelium.
Topics: Amides; Animals; Blood-Brain Barrier; Brain; Drug Interactions; Endothelial Cells; Endothelium; Enzyme Inhibitors; Female; Gene Expression Regulation; Glycation End Products, Advanced; Imidazoles; Mice; Mice, Inbred C57BL; Microfilament Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; rho-Associated Kinases; Threonine | 2011 |
Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement.
Topics: Actins; Amides; Antigens, CD; Bacterial Proteins; Bacterial Toxins; Cadherins; Cell Membrane; Cells, Cultured; Chelating Agents; Cytoskeletal Proteins; Cytoskeleton; Egtazic Acid; Electric Impedance; Endothelial Cells; Gene Knockdown Techniques; Humans; Imidazoles; Lysophospholipids; Membrane Proteins; Microfilament Proteins; Oxadiazoles; p38 Mitogen-Activated Protein Kinases; Permeability; Phosphorylation; Protein Kinase C; Pulmonary Artery; Pyridines; Receptors, Lysosphingolipid; rho GTP-Binding Proteins; rho-Associated Kinases; RNA Interference; Sphingosine; Thiophenes | 2011 |
Gene pathway analysis of the mechanism by which the Rho-associated kinase inhibitor Y-27632 inhibits apoptosis in isolated thawed human embryonic stem cells.
Topics: Amides; Apoptosis; Benzamides; Caspase 10; Caspase 3; Caspase 8; Cell Line; Cell Survival; Cryopreservation; Cryoprotective Agents; Dioxoles; Embryonic Stem Cells; Humans; Imidazoles; Interleukin-1beta; p38 Mitogen-Activated Protein Kinases; Pyridines; rho-Associated Kinases; Transforming Growth Factor beta | 2012 |
Guanine-nucleotide exchange factor H1 mediates lipopolysaccharide-induced interleukin 6 and tumor necrosis factor α expression in endothelial cells via activation of nuclear factor κB.
Topics: Amides; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Gene Expression Regulation; Guanine Nucleotide Exchange Factors; Humans; Imidazoles; Interleukin-6; Lipopolysaccharides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Pyridines; Rho Guanine Nucleotide Exchange Factors; RNA, Messenger; Time Factors; Tumor Necrosis Factor-alpha | 2012 |
RhoA-Rho kinase and platelet-activating factor stimulation of ovine foetal pulmonary vascular smooth muscle cell proliferation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Flavonoids; Imidazoles; Lung; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth, Vascular; Mutation; Platelet Activating Factor; Platelet Membrane Glycoproteins; Pyridines; Receptors, G-Protein-Coupled; rho-Associated Kinases; rhoA GTP-Binding Protein; Sheep | 2013 |
Role of p38, ERK1/2, focal adhesion kinase, RhoA/ROCK and cytoskeleton in the adipogenesis of human mesenchymal stem cells.
Topics: Adipocytes; Adipogenesis; Amides; Butadienes; Cells, Cultured; Cytochalasin D; Cytoskeleton; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Protein-Tyrosine Kinases; Humans; Imidazoles; Mesenchymal Stem Cells; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Quinolones; rho-Associated Kinases; rhoA GTP-Binding Protein; Sulfones | 2014 |
Platelet-derived growth factor-BB induces matrix metalloproteinase-2 expression and rat vascular smooth muscle cell migration via ROCK and ERK/p38 MAPK pathways.
Topics: Amides; Animals; Aorta; Atherosclerosis; Becaplermin; Butadienes; Cell Line; Cell Movement; Gene Expression Regulation; Humans; Imidazoles; Matrix Metalloproteinase 2; Muscle, Smooth, Vascular; Nitriles; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-sis; Pyridines; Rats; rho-Associated Kinases | 2014 |
Rho-kinase regulates human platelet activation induced by thromboxane A2 independently of p38 MAP kinase.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Actin Depolymerizing Factors; Amides; Blood Platelets; Enzyme Inhibitors; Humans; Imidazoles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Activation; Pyridines; rho-Associated Kinases; Signal Transduction; Thromboxane A2 | 2015 |