sb 203580 has been researched along with wortmannin in 82 studies
| Studies (sb 203580) | Trials (sb 203580) | Recent Studies (post-2010) (sb 203580) | Studies (wortmannin) | Trials (wortmannin) | Recent Studies (post-2010) (wortmannin) |
|---|---|---|---|---|---|
| 3,489 | 4 | 1,137 | 4,066 | 2 | 726 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (7.32) | 18.2507 |
| 2000's | 68 (82.93) | 29.6817 |
| 2010's | 7 (8.54) | 24.3611 |
| 2020's | 1 (1.22) | 2.80 |
| Authors | Studies |
|---|---|
| Caivano, M; Cohen, P; Davies, SP; Reddy, H | 1 |
| McGovern, SL; Shoichet, BK | 1 |
| Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H | 1 |
| Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N | 1 |
| Henne, WA; Kularatne, SA; Low, PS; Santhapuram, HK; Vaitilingam, B; Venkatesh, C; Wang, K | 1 |
| Laufer, S; Pillaiyar, T | 1 |
| Begum, N; Duddy, N; McCarthy, M; Ragolia, L; Rienzie, J | 1 |
| Bracke, M; Coffer, PJ; Koenderman, L; Lammers, JW | 1 |
| Coffey, ET; Courtney, MJ | 1 |
| Benítez, D; Buxadé, M; Casaroli-Marano, RP; Espel, E; Fernández-Troy, N; Pérez-Maldonado, C; Ramírez, M | 1 |
| Barnes, PJ; Giembycz, MA; Hellewell, PG; Lindsay, MA; Lynch, OT | 1 |
| Arch, JR; Docherty, K; James, RF; MacFarlane, WM; Tadayyon, M; Wu, H | 1 |
| Fujita, Y; Hirasawa, N; Ohuchi, K; Sato, Y | 1 |
| Heads, RJ; Marber, MS; Mockridge, JW | 1 |
| Fujimoto, M; Fukuyama, H; Kawazoe, Y; Kishimoto, T; Morita, Y; Nagata, S; Naka, T; Nakagawa, R; Narazaki, M | 1 |
| da Silva Xavier, G; Hooper, S; Rafiq, I; Rutter, GA | 1 |
| Dickenson, JM; Germack, R | 1 |
| Alessi, DR; Cuenda, A | 1 |
| Boos, MD; Chini, CC; Dick, CJ; Leibson, PJ; Schoon, RA | 1 |
| Lee, J; Mira-Arbibe, L; Ulevitch, RJ | 1 |
| Chen, CS; Dods, P; Gagnon, A; Roustan-Delatour, N; Sorisky, A | 1 |
| Anversa, P; Bishopric, NH; Discher, DJ; Kajstura, J; Wasserlauf, BJ; Webster, KA; Yamashita, K | 1 |
| Cruise, L; Fuller, G; Ho, LK; Morris, BJ; Veitch, K | 1 |
| Fish, EN; Fujita, S; Grumbach, IM; Lekmine, F; Majchrzak, B; Mayer, IA; Platanias, LC; Ravandi, F; Uddin, S; Verma, A | 1 |
| Buridi, A; Coxon, PY; Kettritz, R; Klein, JB; Manning, T; McLeish, KR; Rane, MJ | 1 |
| Hayashi, M; Klip, A; Konrad, D; Ramlal, T; Somwar, R; Sweeney, G; Yaworsky, K | 1 |
| Chen, KY; Chiu, SL; Hsu, HY; Hua, KF; Wen, MH | 1 |
| Dobashi, K; Ichimonji, I; Iizuka, K; Ishiwara, M; Ishizuka, T; Kawata, T; Mori, M; Nakazawa, T; Okajima, F; Tsukagoshi, H | 1 |
| Bae, MA; Pie, JE; Song, BJ | 1 |
| Docherty, K; Elrick, LJ | 1 |
| Kobayashi, Y; Kurosaka, K; Watanabe, N | 1 |
| Barnes, PJ; Giembycz, MA; Lindsay, MA; Lynch, OT | 1 |
| Brunelleschi, S; Colangelo, D; Gaudino, G; Lavagno, L; Penengo, L; Santoro, C; Viano, I | 1 |
| Kandolf, R; Küpper, JH; Meyer, RG; Rodemann, HP | 1 |
| Gosmanov, AR; Thomason, DB | 1 |
| Betti, M; Canesi, L; Ciacci, C; Citterio, B; Gallo, G; Pruzzo, C; Scarpato, A | 1 |
| Akasaki, T; Inanami, O; Kuwabara, M; Nagahata, H; Sumimoto, H; Yamamori, T | 1 |
| Cruciani, V; Mikalsen, SO | 1 |
| Antonescu, CN; Bilan, PJ; Klip, A; Konrad, D; Liu, Z; Nawaz, Z; Niu, W; Rudich, A; Sweeney, G | 1 |
| Buresi, MC; Buret, AG; Hollenberg, MD; MacNaughton, WK | 1 |
| Kito, K; Nishida, Ki | 1 |
| Kikuta, K; Masamune, A; Sakai, Y; Satoh, A; Satoh, M; Shimosegawa, T | 1 |
| Eggo, MC; Holder, JC; Kumar, S; Patel, NG; Smith, SA | 1 |
| Greenberg, DA; Jin, K; Mao, XO; Zhu, Y | 1 |
| Guan, KL; Inoki, K; Li, Y; Vacratsis, P | 1 |
| Lai, MZ; Wang, JM; Yang-Yen, HF | 1 |
| Andriantsitohaina, R; Beretz, A; Chang, SJ; Chataigneau, M; Chataigneau, T; Keravis, T; Oak, MH; Schini-Kerth, VB; Stoclet, JC | 1 |
| Blanquet, PR; Derer, P; Mariani, J | 1 |
| Dobashi, K; Ishizuka, T; Masubuchi, K; Mori, M; Nakazawa, T; Shimizu, Y; Utsugi, M | 1 |
| Christoffersen, T; Guren, TK; Thoresen, GH | 1 |
| Hebert, C; Nikitakis, NG; Norris, K; Sauk, JJ; Siavash, H; Stewart, J | 1 |
| Coppens, A; Hooghe-Peters, E; Kooijman, R | 1 |
| Agrawal, DK; DelCore, MG; Hunter, WJ; Krueger, KD | 1 |
| Burt, HM; Hampong, M; Higo, TT; Jackson, JK; Pelech, SL; Tudan, C | 1 |
| Consoli, A; De Caterina, R; Madonna, R; Massaro, M; Pandolfi, A | 1 |
| Cohen, RA; Hou, X; Jiang, B; Pimentel, DR; Xu, S | 1 |
| Hori, M; Karaki, H; Ozaki, H; Tasaki, K; Wakabayashi, I | 1 |
| Chung, TW; Kim, CH; Lee, YC | 1 |
| Ariga, H; Matsumoto, K; Minamitani, T; Orba, Y; Sato, M; Sawa, H | 1 |
| Allen, WE; Campbell, M; Sawyer, C; Trimble, ER; Vanhaesebroeck, B | 1 |
| Aikin, R; Maysinger, D; Rosenberg, L | 1 |
| Chiou, WF; Tsai, HR; Tsai, WJ; Yang, LM | 1 |
| Cho, ML; Kim, HY; Kim, KW; Lee, SH; Park, MK; Park, SH; Yoon, CH | 1 |
| Fujisaki, K; Itoh, Y; Kubota, T; Oishi, R; Yano, T | 1 |
| Chang, WC; Tseng, JT; Wang, JM | 1 |
| Iso, T; Kanai, H; Kurabayashi, M; Nagai, R; Ohyama, Y; Sakamoto, H; Sato, H; Sato, M; Tamura, J; Uchiyama, T | 1 |
| Chang, YC; Hsu, JD; Huang, HP; Wang, CJ; Yang, SF | 1 |
| Ferjan, I; Stempelj, M | 1 |
| Blume, N; Friedrichsen, BN; Gram, VK; Lee, YC; Møldrup, A; Neubauer, N; Nielsen, JH; Petersen, JS | 1 |
| Reimer, RA | 1 |
| Gómez, R; Gomez-Reino, JJ; Gualillo, O; Lago, F; Lago, R; Otero, M | 1 |
| Engelbrecht, AM; Louw, L; Toit-Kohn, JL | 1 |
| Chittrakarn, S; Janchawee, B; Kansenalak, S; Keawpradub, N; Purintrapiban, J; Sawangjaroen, K | 1 |
| Caimmi, PP; Grossini, E; Mary, DA; Molinari, C; Ribichini, F; Uberti, F; Vacca, G | 1 |
| Carraro-Lacroix, LR; Girardi, AC; Malnic, G | 1 |
| Balbo, V; Boccafoschi, F; Burlando, B; Mazzucco, L; Ranzato, E | 1 |
| Jeon, YT; Kim, SH; Kim, YB; Lee, SC; Song, YS | 1 |
| Anwer, MS; Schonhoff, CM; Webster, CR | 1 |
| Chen, DB; Feng, L; Liao, WX; Zheng, J | 1 |
| Chetkovich, D; Golding, NL; Khurana, S; Lewis, AS; Liu, Z; Rosa, K | 1 |
| Deng, XL; Li, GR; Su, XL; Wang, Y; Zhao, LM | 1 |
| Anada, T; Ishiko-Uzuka, R; Nishikawa, R; Suzuki, O | 1 |
2 review(s) available for sb 203580 and wortmannin
| Article | Year |
|---|---|
Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy.
Topics: Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Humans; Protein Kinase Inhibitors; SARS-CoV-2; Signal Transduction; Virus Replication | 2022 |
Use of kinase inhibitors to dissect signaling pathways.
Topics: Androstadienes; Animals; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Maleimides; Morpholines; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Sirolimus; Wortmannin | 2000 |
80 other study(ies) available for sb 203580 and wortmannin
| Article | Year |
|---|---|
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides | 2000 |
Kinase inhibitors: not just for kinases anymore.
Topics: beta-Lactamase Inhibitors; beta-Lactamases; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Biological; Phosphotransferases; Scattering, Radiation | 2003 |
Identifying off-target effects and hidden phenotypes of drugs in human cells.
Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship | 2006 |
The selectivity of protein kinase inhibitors: a further update.
Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera | 2007 |
Synthesis and biological analysis of prostate-specific membrane antigen-targeted anticancer prodrugs.
Topics: Antigens, Surface; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Glutamate Carboxypeptidase II; Glutarates; Humans; Ligands; Male; Molecular Targeted Therapy; Prodrugs; Prostatic Neoplasms; Structure-Activity Relationship; Urea | 2010 |
Regulation of mitogen-activated protein kinase phosphatase-1 induction by insulin in vascular smooth muscle cells. Evaluation of the role of the nitric oxide signaling pathway and potential defects in hypertension.
Topics: Androstadienes; Animals; Cell Cycle Proteins; Cells, Cultured; Cyclic GMP; Dual Specificity Phosphatase 1; Enzyme Inhibitors; Flavonoids; Imidazoles; Immediate-Early Proteins; Insulin; Male; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger; Signal Transduction; Wortmannin | 1998 |
Analysis of signal transduction pathways regulating cytokine-mediated Fc receptor activation on human eosinophils.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Enzyme Activation; Enzyme Inhibitors; Eosinophils; Flavonoids; Humans; Imidazoles; Immunoglobulin A; Immunoglobulin G; Interleukin-4; Interleukin-5; Microspheres; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Pyridines; Receptors, Fc; Receptors, IgG; Rosette Formation; Signal Transduction; Th2 Cells; Wortmannin | 1998 |
The mechanism of Ara-C-induced apoptosis of differentiating cerebellar granule neurons.
Topics: Androstadienes; Animals; Antimetabolites, Antineoplastic; Apoptosis; Benzamides; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Differentiation; Cell Survival; Cerebellum; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Cytarabine; Enzyme Inhibitors; Flavonoids; Imatinib Mesylate; Imidazoles; Mitogen-Activated Protein Kinase 12; Mitogen-Activated Protein Kinases; Neurons; Piperazines; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Kinases; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Purines; Pyridines; Pyrimidines; Rats; Roscovitine; Signal Transduction; Stress, Physiological; Wortmannin | 1999 |
Wortmannin inhibits translation of tumor necrosis factor-alpha in superantigen-activated T cells.
Topics: Androstadienes; Bacterial Toxins; CD4-Positive T-Lymphocytes; Chromones; Enterotoxins; Enzyme Inhibitors; Humans; Imidazoles; Immunosuppressive Agents; Morpholines; Phosphatidylinositol 3-Kinases; Pyridines; RNA, Messenger; Superantigens; Transcription, Genetic; Tumor Necrosis Factor-alpha; Wortmannin | 1999 |
'Outside-in' signalling mechanisms underlying CD11b/CD18-mediated NADPH oxidase activation in human adherent blood eosinophils.
Topics: Androstadienes; Carbazoles; CD18 Antigens; Cell Adhesion; Cell Count; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Eosinophils; Humans; Imidazoles; Indoles; Isoenzymes; Macrophage-1 Antigen; Maleimides; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyrazoles; Pyridines; Pyrimidines; Signal Transduction; src-Family Kinases; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin | 1999 |
Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromones; DNA-Binding Proteins; Glucose; Homeodomain Proteins; Humans; Imidazoles; Insulin; Islets of Langerhans; Mitogen-Activated Protein Kinases; Morpholines; Oligodeoxyribonucleotides; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Promoter Regions, Genetic; Pyridines; Trans-Activators; Transfection; Wortmannin | 1999 |
Involvement of a phosphatidylinositol 3-kinase-p38 mitogen activated protein kinase pathway in antigen-induced IL-4 production in mast cells.
Topics: Activating Transcription Factor 2; Androstadienes; Animals; Cell Line; Chromones; Cyclic AMP Response Element-Binding Protein; Dinitrophenols; Enzyme Activation; Flavonoids; Imidazoles; Interleukin-4; Mast Cells; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Pyridines; Rats; Serum Albumin; Transcription Factors; Wortmannin | 2000 |
Activation of Akt during simulated ischemia/reperfusion in cardiac myocytes.
Topics: Androstadienes; Animals; Animals, Newborn; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Genistein; Imidazoles; Kinetics; Models, Cardiovascular; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Pyridines; Rats; Retroviridae Proteins, Oncogenic; Wortmannin | 2000 |
Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts.
Topics: Androstadienes; Animals; Carrier Proteins; Caspase 3; Caspase Inhibitors; Caspases; Cell Death; Cell Survival; Cytokines; DNA-Binding Proteins; Embryo, Mammalian; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Imidazoles; Interferon-gamma; Interleukin-1; Kinetics; L Cells; Mice; Mice, Knockout; Pyridines; Recombinant Proteins; Repressor Proteins; Signal Transduction; STAT1 Transcription Factor; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling Proteins; Trans-Activators; Transfection; Tumor Necrosis Factor-alpha; Wortmannin | 2000 |
Glucose-stimulated preproinsulin gene expression and nuclear trans-location of pancreatic duodenum homeobox-1 require activation of phosphatidylinositol 3-kinase but not p38 MAPK/SAPK2.
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Nucleus; Chromones; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Glucose; Homeodomain Proteins; Imidazoles; Insulin; Islets of Langerhans; MAP Kinase Kinase 6; Microscopy, Confocal; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Proinsulin; Promoter Regions, Genetic; Protein Kinase C; Protein Precursors; Pyridines; Signal Transduction; Trans-Activators; Transfection; Wortmannin | 2000 |
Activation of protein kinase B by the A(1)-adenosine receptor in DDT(1)MF-2 cells.
Topics: Adenosine; Androstadienes; Animals; Calcium; Cell Line; Chromones; Cricetinae; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Imidazoles; Indoles; Insulin; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyridines; Receptors, Purinergic P1; Virulence Factors, Bordetella; Wortmannin; Xanthines | 2000 |
Regulation of p38 mitogen-activated protein kinase during NK cell activation.
Topics: Androstadienes; Antibody-Dependent Cell Cytotoxicity; Cytotoxicity, Immunologic; Enzyme Inhibitors; Enzyme Precursors; Flavonoids; Humans; Imidazoles; Indoles; Intracellular Signaling Peptides and Proteins; Killer Cells, Natural; Lymphocyte Activation; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Pyridines; Receptors, IgG; src-Family Kinases; Syk Kinase; Wortmannin | 2000 |
TAK1 regulates multiple protein kinase cascades activated by bacterial lipopolysaccharide.
Topics: Androstadienes; Animals; Apoptosis; Cell Line; Chromones; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Hydrogen Peroxide; Hypertonic Solutions; I-kappa B Kinase; Imidazoles; Inflammation; Insulin-Like Growth Factor I; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Morpholines; NF-kappa B; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Prostaglandins A; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Recombinant Fusion Proteins; Signal Transduction; Stress, Physiological; Transfection; Tumor Cells, Cultured; Wortmannin | 2000 |
Phosphatidylinositol-3,4,5-trisphosphate is required for insulin-like growth factor 1-mediated survival of 3T3-L1 preadipocytes.
Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; Apoptosis; Chromones; Culture Media, Serum-Free; Enzyme Inhibitors; Flavonoids; Imidazoles; In Situ Nick-End Labeling; Insulin-Like Growth Factor I; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Sirolimus; Wortmannin | 2001 |
Reperfusion-activated Akt kinase prevents apoptosis in transgenic mouse hearts overexpressing insulin-like growth factor-1.
Topics: Androstadienes; Animals; Apoptosis; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Female; Genotype; Imidazoles; Insulin-Like Growth Factor I; Male; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; p38 Mitogen-Activated Protein Kinases; Perfusion; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Wortmannin | 2001 |
Activation of p44/p42 MAP kinase in striatal neurons via kainate receptors and PI3 kinase.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Androstadienes; Animals; Corpus Striatum; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Kainic Acid; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; N-Methylaspartate; Neurons; Phosphatidylinositol 3-Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Wortmannin | 2001 |
The p38 MAPK pathway mediates the growth inhibitory effects of interferon-alpha in BCR-ABL-expressing cells.
Topics: Androstadienes; Cell Division; Cell Line; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Genistein; Humans; Imidazoles; Immunoblotting; Interferon-alpha; Intracellular Signaling Peptides and Proteins; K562 Cells; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Tyrosine; Wortmannin | 2001 |
Role of extracellular signal-regulated kinase and phosphatidylinositol-3 kinase in chemoattractant and LPS delay of constitutive neutrophil apoptosis.
Topics: Androstadienes; Apoptosis; Chemotaxis, Leukocyte; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Leukotriene B4; Lipopolysaccharides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Virulence Factors, Bordetella; Wortmannin | 2001 |
The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation.
Topics: 3T3 Cells; Androstadienes; Animals; Arabidopsis Proteins; Biological Transport; Deoxyglucose; Enzyme Inhibitors; Glucose; Glucose Transporter Type 4; Hypoglycemic Agents; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Monosaccharide Transport Proteins; Muscle Fibers, Skeletal; Muscle Proteins; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Plant Proteins; Potassium Channels; Pyridines; Thioctic Acid; Wortmannin | 2001 |
Ligands of macrophage scavenger receptor induce cytokine expression via differential modulation of protein kinase signaling pathways.
Topics: Androstadienes; Animals; Cell Adhesion Molecules; Cell Line; Chromones; Cytokines; Enzyme Inhibitors; Flavonoids; Fucose; Gene Expression Regulation; Imidazoles; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Kinetics; Ligands; Lipoproteins, LDL; Macrophages; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Morpholines; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Polysaccharides; Pyridines; Receptors, Immunologic; Receptors, Scavenger; Time Factors; Tumor Necrosis Factor-alpha; Wortmannin | 2001 |
Sensitized mast cells migrate toward the antigen: a response regulated by p38 mitogen-activated protein kinase and Rho-associated coiled-coil-forming protein kinase.
Topics: Androstadienes; Animals; Cell Movement; Cells, Cultured; Clone Cells; Dinitrophenols; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Haptens; Imidazoles; Immunization; Immunoglobulin E; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 1; Mast Cells; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-kit; Pyridines; Receptors, IgE; rho-Associated Kinases; Serum Albumin; Wortmannin | 2001 |
Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH(2)-terminal protein kinase-related cell death pathway.
Topics: Acetaminophen; Acetanilides; Analgesics; Analgesics, Non-Narcotic; Androstadienes; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspases; Cytochrome c Group; Cytochrome P-450 CYP2E1; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Glioma; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyridines; Rats; Thiazoles; Time Factors; Tumor Cells, Cultured; Wortmannin | 2001 |
Phosphorylation-dependent nucleocytoplasmic shuttling of pancreatic duodenal homeobox-1.
Topics: Androstadienes; Arsenites; Biological Transport; Cell Line; Cell Nucleus; Cytoplasm; Enzyme Inhibitors; Glucose; Homeodomain Proteins; Humans; Imidazoles; Immunohistochemistry; Insulin; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Pyridines; Sodium Compounds; Trans-Activators; Wortmannin | 2001 |
Production of proinflammatory cytokines by resident tissue macrophages after phagocytosis of apoptotic cells.
Topics: Androstadienes; Animals; Apoptosis; Cell Line; Cells, Cultured; Chemokine CXCL2; Chemokines; Colchicine; Cytokines; Enzyme Inhibitors; Imidazoles; Kupffer Cells; Lipopolysaccharides; Macrophages, Alveolar; Male; Mice; Mice, Inbred C57BL; Phagocytosis; Pyridines; RNA, Messenger; T-Lymphocytes; Thymus Gland; Wortmannin | 2001 |
Pharmacological comparison of LTB(4)-induced NADPH oxidase activation in adherent and non-adherent guinea-pig eosinophils.
Topics: Androstadienes; Animals; Antibodies; Carbazoles; CD18 Antigens; Cell Adhesion; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Eosinophils; Flavonoids; Guinea Pigs; Imidazoles; Indoles; Integrin beta1; Intracellular Signaling Peptides and Proteins; Leukotriene B4; Macrophage-1 Antigen; Male; Maleimides; Mitogen-Activated Protein Kinases; NADPH Oxidases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein-Tyrosine Kinases; Pyrazoles; Pyridines; Pyrimidines; Rats; src-Family Kinases; Stilbenes; Syk Kinase; Time Factors; Wortmannin | 2001 |
Macrophage stimulating protein (MSP) evokes superoxide anion production by human macrophages of different origin.
Topics: Adult; Androstadienes; Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Flavonoids; Growth Substances; Hepatocyte Growth Factor; Humans; Imidazoles; Insecta; Macrophages; Middle Aged; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Protein Kinase C; Proto-Oncogene Proteins; Pyridines; Receptors, Drug; Respiratory Burst; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin | 2001 |
Early growth response-1 gene (Egr-1) promoter induction by ionizing radiation in U87 malignant glioma cells in vitro.
Topics: Androstadienes; Anisomycin; Blotting, Western; Colforsin; DNA-Binding Proteins; Early Growth Response Protein 1; Epidermal Growth Factor; Flavonoids; Glioma; Humans; Imidazoles; Immediate-Early Proteins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Pyridines; Suramin; Transcription Factors; Wortmannin | 2002 |
Insulin and isoproterenol differentially regulate mitogen-activated protein kinase-dependent Na(+)-K(+)-2Cl(-) cotransporter activity in skeletal muscle.
Topics: Androstadienes; Animals; Chromones; Female; Imidazoles; Insulin; Isoproterenol; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Potassium; Pyridines; Rats; Rats, Sprague-Dawley; Rubidium Radioisotopes; Sodium-Potassium-Chloride Symporters; Wortmannin | 2002 |
Signaling pathways involved in the physiological response of mussel hemocytes to bacterial challenge: the role of stress-activated p38 MAP kinases.
Topics: Androstadienes; Animals; Bivalvia; Enzyme Activation; Enzyme Inhibitors; Escherichia coli; Flavonoids; Hemocytes; Imidazoles; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; Wortmannin | 2002 |
Relationship between p38 mitogen-activated protein kinase and small GTPase Rac for the activation of NADPH oxidase in bovine neutrophils.
Topics: Androstadienes; Animals; Cattle; Chromones; Cytosol; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Glutathione Transferase; Imidazoles; Immunohistochemistry; Mitogen-Activated Protein Kinases; Morpholines; NADPH Oxidases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoproteins; Protein Binding; Protein Structure, Tertiary; Pyridines; rac GTP-Binding Proteins; Recombinant Fusion Proteins; Superoxides; Time Factors; Wortmannin; Zymosan | 2002 |
Mechanisms involved in responses to the poroxisome proliferator WY-14,643 on gap junctional intercellular communication in V79 hamster fibroblasts.
Topics: Acetophenones; Androstadienes; Animals; Benzopyrans; Brefeldin A; Butadienes; Cell Communication; Cells, Cultured; Cricetinae; Cricetulus; Enzyme Inhibitors; Flavonoids; Gap Junctions; Imidazoles; Indoles; Maleimides; Mesocricetus; Mitogen-Activated Protein Kinases; Nitriles; Peroxisome Proliferators; Protein Kinase C; Protein Synthesis Inhibitors; Pyridines; Pyrimidines; Signal Transduction; Sirolimus; Wortmannin | 2002 |
Need for GLUT4 activation to reach maximum effect of insulin-mediated glucose uptake in brown adipocytes isolated from GLUT4myc-expressing mice.
Topics: Adipocytes; Adipose Tissue, Brown; Androstadienes; Animals; Biological Transport; Cell Membrane; Deoxyglucose; Enzyme Inhibitors; Glucose; Glucose Tolerance Test; Glucose Transporter Type 4; Heterozygote; HIV Protease Inhibitors; Humans; Imidazoles; Indinavir; Insulin; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Monosaccharide Transport Proteins; Muscle Proteins; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-myc; Pyridines; Rats; Sequence Tagged Sites; Wortmannin | 2002 |
Activation of proteinase-activated receptor 1 stimulates epithelial chloride secretion through a unique MAP kinase- and cyclo-oxygenase-dependent pathway.
Topics: Androstadienes; Butadienes; Cell Line; Chlorides; Epithelial Cells; Humans; Imidazoles; Indoles; Maleimides; Mitogen-Activated Protein Kinases; Nitriles; Nitrobenzenes; Phospholipases A; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Pyridines; Pyrimidines; Quinazolines; Receptor, PAR-1; Receptors, Thrombin; Signal Transduction; Sulfonamides; Thrombin; Tyrphostins; Wortmannin | 2002 |
Nonrequirement of continuous stimulation with MCP-1 for cell migration and determination of directional migration by initial stimulation with chemokine.
Topics: Androstadienes; Cell Communication; Cell Movement; Cells, Cultured; Chemokine CCL2; Enzyme Inhibitors; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Monocytes; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; Wortmannin | 2002 |
Inhibition of p38 mitogen-activated protein kinase blocks activation of rat pancreatic stellate cells.
Topics: Actins; Androstadienes; Animals; Blotting, Northern; Blotting, Western; Cell Division; Cell Nucleus; Cells, Cultured; Chemokine CCL2; Electrophoresis; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Imidazoles; Interleukin-1; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pancreas; Phosphorylation; Platelet-Derived Growth Factor; Procollagen; Procollagen-Proline Dioxygenase; Protein Serine-Threonine Kinases; Pyridines; Rats; Wortmannin | 2003 |
Differential regulation of lipogenesis and leptin production by independent signaling pathways and rosiglitazone during human adipocyte differentiation.
Topics: Adipocytes; Androstadienes; Cell Differentiation; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Leptin; Lipid Metabolism; Lipids; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Rosiglitazone; Signal Transduction; Sirolimus; Stem Cells; Thiazoles; Thiazolidinediones; Tumor Necrosis Factor-alpha; Wortmannin | 2003 |
Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expression.
Topics: Androstadienes; Animals; Blotting, Western; Bromodeoxyuridine; Cell Cycle Proteins; Cell Division; Cell Nucleus; Cells, Cultured; Cerebral Cortex; Cyclin A; Cyclin D1; Cyclin E; DNA-Binding Proteins; Dose-Response Relationship, Drug; E2F Transcription Factors; E2F1 Transcription Factor; E2F2 Transcription Factor; E2F3 Transcription Factor; Electrophoresis, Polyacrylamide Gel; Endothelial Growth Factors; Flavonoids; Imidazoles; Intercellular Signaling Peptides and Proteins; Lymphokines; Mice; Proliferating Cell Nuclear Antigen; Pyridines; Signal Transduction; Time Factors; Transcription Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin | 2003 |
The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.
Topics: 14-3-3 Proteins; Amino Acid Sequence; Androstadienes; Anisomycin; Binding Sites; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Genes, Dominant; Glutathione Transferase; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Mass Spectrometry; Mitogen-Activated Protein Kinases; Models, Biological; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Recombinant Fusion Proteins; Repressor Proteins; Sequence Homology, Amino Acid; Serine; Time Factors; Tuberous Sclerosis; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins; Tyrosine 3-Monooxygenase; Wortmannin | 2003 |
Interleukin-3 stimulation of mcl-1 gene transcription involves activation of the PU.1 transcription factor through a p38 mitogen-activated protein kinase-dependent pathway.
Topics: Androstadienes; Animals; Cell Line; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Genes, Immediate-Early; Hematopoietic Stem Cells; Humans; Imidazoles; Interleukin-3; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Promoter Regions, Genetic; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyridines; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Trans-Activators; Transcription, Genetic; Wortmannin | 2003 |
Red wine polyphenolic compounds inhibit vascular endothelial growth factor expression in vascular smooth muscle cells by preventing the activation of the p38 mitogen-activated protein kinase pathway.
Topics: Androstadienes; Animals; Antioxidants; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Onium Compounds; p38 Mitogen-Activated Protein Kinases; Phenols; Phosphorylation; Platelet-Derived Growth Factor; Polyphenols; Protein Processing, Post-Translational; Pyridines; Rats; Reactive Oxygen Species; RNA, Messenger; Thrombin; Transforming Growth Factor beta; Transforming Growth Factor beta1; Vascular Endothelial Growth Factor A; Wine; Wortmannin | 2003 |
A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Androstadienes; Animals; Antibodies; Benzophenanthridines; Benzopyrans; Blotting, Western; Brain-Derived Neurotrophic Factor; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carbazoles; Cell Nucleus; Chromones; Cyclic AMP Response Element-Binding Protein; Cytosol; Enzyme Inhibitors; Flavonoids; Hippocampus; Imidazoles; Immunohistochemistry; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Male; Morpholines; Naphthalenes; Phenanthridines; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Rats; Signal Transduction; Time Factors; Tyrphostins; Wortmannin | 2003 |
C-Jun-NH2-terminal kinase mediates expression of connective tissue growth factor induced by transforming growth factor-beta1 in human lung fibroblasts.
Topics: Androstadienes; Anthracenes; Cells, Cultured; Chromones; Connective Tissue Growth Factor; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation; Humans; Imidazoles; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Lung; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinases; Morpholines; Oligonucleotides, Antisense; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pyridines; RNA, Messenger; Smad2 Protein; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1; Wortmannin | 2003 |
Role of ERK, p38 and PI3-kinase in EGF receptor-mediated mitogenic signalling in cultured rat hepatocytes: requirement for sustained ERK activation.
Topics: Androstadienes; Animals; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Imidazoles; Male; Mitogen-Activated Protein Kinases; Mitogens; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; Signal Transduction; Wortmannin | 2003 |
Phenotypic switching of VEGF and collagen XVIII during hypoxia in head and neck squamous carcinoma cells.
Topics: Acetylcysteine; Androstadienes; Antimutagenic Agents; Biomarkers; Cell Hypoxia; Cell Line, Tumor; Cobalt; Collagen Type XVIII; Enzyme Inhibitors; Head and Neck Neoplasms; Heat-Shock Proteins; HSP47 Heat-Shock Proteins; Humans; Imidazoles; MAP Kinase Signaling System; Neovascularization, Pathologic; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Vascular Endothelial Growth Factor A; Wortmannin | 2003 |
IGF-I stimulates IL-8 production in the promyelocytic cell line HL-60 through activation of extracellular signal-regulated protein kinase.
Topics: Androstadienes; Anthracenes; Apoptosis; Butadienes; Cell Survival; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Leukemic; HL-60 Cells; Humans; Hydrogen Peroxide; Imidazoles; Insulin-Like Growth Factor I; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Kinetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oxazoles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptor, IGF Type 1; RNA, Messenger; Wortmannin | 2003 |
Calphostin C as a rapid and strong inducer of apoptosis in human coronary artery smooth muscle cells.
Topics: Androstadienes; Animals; Apoptosis; Cells, Cultured; Chromones; Coronary Vessels; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Flavonoids; Humans; Imidazoles; In Situ Nick-End Labeling; Insulin-Like Growth Factor I; Microscopy, Electron, Scanning; Microscopy, Video; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth, Vascular; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; Staurosporine; Time Factors; Wortmannin | 2003 |
Calcium pyrophosphate dihydrate crystal associated induction of neutrophil activation and repression of TNF-alpha-induced apoptosis is mediated by the p38 MAP kinase.
Topics: Androstadienes; Apoptosis; Calcium Pyrophosphate; Caspase 3; Caspases; Cell Degranulation; Crystallization; DNA Fragmentation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Muramidase; Neutrophil Activation; Neutrophils; p38 Mitogen-Activated Protein Kinases; Peroxidase; Pyridines; Superoxides; Tumor Necrosis Factor-alpha; Wortmannin | 2004 |
Insulin enhances vascular cell adhesion molecule-1 expression in human cultured endothelial cells through a pro-atherogenic pathway mediated by p38 mitogen-activated protein-kinase.
Topics: Androstadienes; Arteriosclerosis; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation; Humans; Imidazoles; Insulin; Intercellular Adhesion Molecule-1; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; Umbilical Veins; Wortmannin | 2004 |
Angiotensin II differentially regulates interleukin-1-beta-inducible NO synthase (iNOS) and vascular cell adhesion molecule-1 (VCAM-1) expression: role of p38 MAPK.
Topics: Adenoviridae; Androstadienes; Angiotensin II; Animals; Blotting, Western; Cells, Cultured; Cyclooxygenase 2; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Inflammation; Interleukin-1; Isoenzymes; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Models, Biological; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Vascular Cell Adhesion Molecule-1; Wortmannin | 2004 |
Mechanism of human urotensin II-induced contraction in rat aorta.
Topics: Androstadienes; Animals; Aorta, Thoracic; Butadienes; Calcium; Carbazoles; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Indoles; Lanthanum; Male; Maleimides; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle Contraction; Myosin Light Chains; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Potassium Chloride; Protein Kinase C; Pyridines; Rats; Rats, Wistar; Thapsigargin; Urotensins; Verapamil; Wortmannin | 2004 |
Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential.
Topics: Androstadienes; Butadienes; Cell Line; Enzyme Inhibitors; Gene Expression Regulation, Viral; Hepatitis B virus; Hepatocytes; Humans; Imidazoles; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; NF-kappa B; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Recombinant Fusion Proteins; Signal Transduction; Trans-Activators; Transcription, Genetic; Transfection; Viral Regulatory and Accessory Proteins; Wortmannin | 2004 |
Induction of matrix metalloproteinase-2 by tenascin-X deficiency is mediated through the c-Jun N-terminal kinase and protein tyrosine kinase phosphorylation pathway.
Topics: Androstadienes; Animals; Animals, Newborn; Anthracenes; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Genistein; Imidazoles; Male; Matrix Metalloproteinase 2; Mice; Mice, Knockout; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-jun; Pyridines; Skin; Tenascin; Wortmannin | 2004 |
Glucose-potentiated chemotaxis in human vascular smooth muscle is dependent on cross-talk between the PI3K and MAPK signaling pathways.
Topics: Alkyl and Aryl Transferases; Androstadienes; Anthracenes; Antibodies, Monoclonal; Cells, Cultured; Chemotaxis; Chromones; Class I Phosphatidylinositol 3-Kinases; Farnesyltranstransferase; Flavonoids; Glucose; Humans; Imidazoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Lovastatin; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Polyisoprenyl Phosphates; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; ras Proteins; Sesquiterpenes; Sirolimus; TOR Serine-Threonine Kinases; Wortmannin | 2004 |
Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets.
Topics: Androstadienes; Anthracenes; Apoptosis; Cell Death; Culture Techniques; Cytokines; Cytoprotection; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Insulin-Like Growth Factor I; Islets of Langerhans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Tissue Survival; Wortmannin | 2004 |
Andrographolide acts through inhibition of ERK1/2 and Akt phosphorylation to suppress chemotactic migration.
Topics: Androstadienes; Animals; Anthracenes; Cell Line; Cell Movement; Cell Survival; Chemokine CCL4; Chemotaxis; Chromones; Complement C5a; Diterpenes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Macrophage Inflammatory Proteins; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Wortmannin | 2004 |
Increased interleukin-17 production via a phosphoinositide 3-kinase/Akt and nuclear factor kappaB-dependent pathway in patients with rheumatoid arthritis.
Topics: Adult; Aged; Androstadienes; Antibodies, Monoclonal; Arthritis, Rheumatoid; CD28 Antigens; CD3 Complex; CD4-Positive T-Lymphocytes; Chemokines; Chromones; Cytokines; Female; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Interleukin-17; Leukocytes, Mononuclear; Lymphocyte Activation; Male; Middle Aged; Morpholines; NF-kappa B; Osteoarthritis; Phosphatidylinositol 3-Kinases; Phytohemagglutinins; Proto-Oncogene Proteins c-akt; Pyridines; Pyrrolidines; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thiocarbamates; Wortmannin | 2005 |
Fenofibrate induces apoptotic injury in cultured human hepatocytes by inhibiting phosphorylation of Akt.
Topics: Androstadienes; Annexin A5; Apoptosis; Caspases; Cell Line; Cell Membrane; Cell Nucleus; Cell Survival; DNA; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fenofibrate; Hepatocytes; Humans; Hydroxyeicosatetraenoic Acids; Hypolipidemic Agents; Imidazoles; In Situ Nick-End Labeling; Insulin; Microscopy, Fluorescence; Phosphatidylinositol 3-Kinases; Phosphatidylserines; Phosphorylation; PPAR alpha; Propidium; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Wortmannin | 2005 |
Induction of human NF-IL6beta by epidermal growth factor is mediated through the p38 signaling pathway and cAMP response element-binding protein activation in A431 cells.
Topics: Amino Acid Motifs; Androstadienes; Blotting, Western; CCAAT-Enhancer-Binding Protein-delta; Cell Line, Tumor; Cell Nucleus; Chromatin Immunoprecipitation; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Epidermal Growth Factor; Genes, Reporter; Humans; Imidazoles; Inflammation; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plasmids; Promoter Regions, Genetic; Protein Binding; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sp1 Transcription Factor; Time Factors; Transfection; Wortmannin | 2005 |
Mitochondrial reactive oxygen species and c-Src play a critical role in hypoxic response in vascular smooth muscle cells.
Topics: Androstadienes; Animals; Blotting, Northern; Catalase; Cell Hypoxia; Cell Line; Flavonoids; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Immunoblotting; Microscopy, Fluorescence; Mitochondria; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naphthalenes; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Plasminogen Activator Inhibitor 1; Protein Kinase Inhibitors; Proto-Oncogene Proteins pp60(c-src); Pyrazoles; Pyridines; Pyrimidines; Rabbits; RNA, Messenger; Rotenone; Wortmannin | 2005 |
Hibiscus anthocyanins rich extract-induced apoptotic cell death in human promyelocytic leukemia cells.
Topics: Androstadienes; Anthocyanins; Anthracenes; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Caspases; Cell Survival; Cytochromes c; DNA, Mitochondrial; Dose-Response Relationship, Drug; Fas Ligand Protein; Flavonoids; Flowers; Hibiscus; HL-60 Cells; Humans; Imidazoles; Membrane Glycoproteins; p38 Mitogen-Activated Protein Kinases; Plant Extracts; Proto-Oncogene Proteins c-jun; Pyridines; RNA, Messenger; Time Factors; Wortmannin | 2005 |
Signaling pathway in nerve growth factor induced histamine release from rat mast cells.
Topics: Analysis of Variance; Androstadienes; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Flavonoids; Histamine; Imidazoles; Indoles; Male; Maleimides; Mast Cells; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Kinase C; Pyridines; Pyrrolidinones; Rats; Rats, Wistar; Signal Transduction; Staurosporine; Tyrosine; Wortmannin | 2005 |
Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways.
Topics: Adenylyl Cyclases; Androstadienes; Animals; Animals, Newborn; Cell Line; Cell Proliferation; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyclin D1; Enzyme Activation; Flavonoids; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Human Growth Hormone; Imidazoles; Insulin-Secreting Cells; Isoquinolines; Liraglutide; Mitogen-Activated Protein Kinase Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Rats; Signal Transduction; Stimulation, Chemical; Sulfonamides; Transcription, Genetic; Transduction, Genetic; Wortmannin | 2006 |
Meat hydrolysate and essential amino acid-induced glucagon-like peptide-1 secretion, in the human NCI-H716 enteroendocrine cell line, is regulated by extracellular signal-regulated kinase1/2 and p38 mitogen-activated protein kinases.
Topics: Amino Acids, Essential; Androstadienes; Blotting, Western; Butadienes; Cell Line; Depression, Chemical; Enterocytes; Enzyme Activation; Glucagon-Like Peptide 1; Humans; Imidazoles; Meat; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Hydrolysates; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Statistics, Nonparametric; Wortmannin | 2006 |
Phosphatidylinositol 3-kinase, MEK-1 and p38 mediate leptin/interferon-gamma synergistic NOS type II induction in chondrocytes.
Topics: Androstadienes; Animals; Blotting, Western; Cell Line; Cells, Cultured; Chondrocytes; Chromones; Enzyme Induction; Enzyme Inhibitors; Enzymes; Flavonoids; Humans; Imidazoles; Interferon-gamma; Leptin; MAP Kinase Kinase 1; Morpholines; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Wortmannin | 2007 |
Docosahexaenoic acid induces apoptosis in colorectal carcinoma cells by modulating the PI3 kinase and p38 MAPK pathways.
Topics: Adenocarcinoma; Androstadienes; Apoptosis; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Docosahexaenoic Acids; Humans; Imidazoles; Kinetics; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Tumor Cells, Cultured; Wortmannin | 2009 |
Study on glucose transport in muscle cells by extracts from Mitragyna speciosa (Korth) and mitragynine.
Topics: Androstadienes; Animals; Blotting, Western; Cell Line; Enzyme Inhibitors; Glucose; Imidazoles; Insulin; Mitragyna; Muscles; Plant Extracts; Pyridines; Rats; Secologanin Tryptamine Alkaloids; Signal Transduction; Wortmannin | 2011 |
Urocortin II induces nitric oxide production through cAMP and Ca2+ related pathways in endothelial cells.
Topics: Androstadienes; Animals; Aorta; Blotting, Western; Butadienes; Calcimycin; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Dideoxyadenosine; Endothelial Cells; Imidazoles; Ionophores; Mitogen-Activated Protein Kinase 3; Nitric Oxide; Nitriles; Oncogene Protein v-akt; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Peptides, Cyclic; Pyridines; Signal Transduction; Swine; Urocortins; Wortmannin | 2009 |
Long-term regulation of vacuolar H(+)-ATPase by angiotensin II in proximal tubule cells.
Topics: Ammonium Chloride; Androstadienes; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Buffers; Cell Line, Transformed; Cell Membrane; Cycloheximide; Dactinomycin; Epithelial Cells; Gene Expression; Genistein; Hydrogen-Ion Concentration; Imidazoles; Kidney Tubules, Proximal; Losartan; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Subunits; Protein Transport; Protein-Tyrosine Kinases; Pyridines; Rats; Time Factors; Up-Regulation; Vacuolar Proton-Translocating ATPases; Wortmannin | 2009 |
Scratch wound closure of C2C12 mouse myoblasts is enhanced by human platelet lysate.
Topics: Androstadienes; Animals; Blood Platelets; Cell Line; Cell Movement; Chemotaxis; Complex Mixtures; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; Mice; Myoblasts; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Wortmannin; Wound Healing | 2009 |
Genistein inhibits cell growth by modulating various mitogen-activated protein kinases and AKT in cervical cancer cells.
Topics: Androstadienes; Anthracenes; Anticarcinogenic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Flavonoids; Genistein; HeLa Cells; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Uterine Cervical Neoplasms; Wortmannin | 2009 |
Cyclic AMP stimulates Mrp2 translocation by activating p38{alpha} MAPK in hepatic cells.
Topics: Androstadienes; Animals; Cell Line, Tumor; Cyclic AMP; Hepatocytes; Humans; Imidazoles; MAP Kinase Kinase 6; MAP Kinase Kinase Kinases; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; p38 Mitogen-Activated Protein Kinases; Protein Transport; Pyridines; Rats; Transfection; Wortmannin | 2010 |
Deciphering mechanisms controlling placental artery endothelial cell migration stimulated by vascular endothelial growth factor.
Topics: Androstadienes; Animals; Anthracenes; Arteries; Butadienes; Caveolin 1; Cell Movement; Cells, Cultured; CSK Tyrosine-Protein Kinase; Electrophoresis, Polyacrylamide Gel; Endothelial Cells; Enzyme Inhibitors; Female; Focal Adhesion Protein-Tyrosine Kinases; Imidazoles; Immunoprecipitation; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitric Oxide Synthase Type III; Nitriles; Nitrogen Oxides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Placenta; Pregnancy; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Sheep; Signal Transduction; src-Family Kinases; Vascular Endothelial Growth Factor A; Wortmannin | 2010 |
An essential role for modulation of hyperpolarization-activated current in the development of binaural temporal precision.
Topics: Age Factors; Analysis of Variance; Androstadienes; Animals; Biophysical Phenomena; Bucladesine; Colforsin; Cyclic Nucleotide-Gated Cation Channels; Electric Stimulation; Enzyme Inhibitors; Female; Gene Expression Regulation, Developmental; Gerbillinae; Imidazoles; In Vitro Techniques; Ion Channel Gating; Male; Neurons; Olivary Nucleus; Patch-Clamp Techniques; Pyridines; Pyrimidines; Wortmannin | 2012 |
KCa3.1 channels mediate the increase of cell migration and proliferation by advanced glycation endproducts in cultured rat vascular smooth muscle cells.
Topics: Analysis of Variance; Androstadienes; Animals; Blotting, Western; Butadienes; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Flavonoids; Glycation End Products, Advanced; Imidazoles; Intermediate-Conductance Calcium-Activated Potassium Channels; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; Patch-Clamp Techniques; Pyridines; Rats; RNA Interference; RNA, Small Interfering; Serum Albumin, Bovine; Signal Transduction; Wortmannin | 2013 |
Osteoblastic differentiation of stromal ST-2 cells from octacalcium phosphate exposure via p38 signaling pathway.
Topics: Alkaline Phosphatase; Androstadienes; Animals; Calcium Phosphates; Cell Differentiation; Cell Line; Cell Proliferation; Flavonoids; Imidazoles; Mice; Molecular Structure; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Stromal Cells; Wortmannin | 2014 |