Compounds > sb 203580
Page last updated: 2024-09-05

sb 203580 and u-50488

sb 203580 has been researched along with u-50488 in 5 studies

Compound Research Comparison

Studies
(sb 203580)		Trials
(sb 203580)		Recent Studies (post-2010)
(sb 203580)		Studies
(u-50488)		Trials
(u-50488)		Recent Studies (post-2010) (u-50488)
3,48941,1371,6643209

Protein Interaction Comparison

ProteinTaxonomysb 203580 (IC50)u-50488 (IC50)
Delta-type opioid receptorRattus norvegicus (Norway rat)2.15
Kappa-type opioid receptorMus musculus (house mouse)0.0027
Mu-type opioid receptorRattus norvegicus (Norway rat)2.15
Kappa-type opioid receptorRattus norvegicus (Norway rat)0.7171
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.0958
Kappa-type opioid receptorHomo sapiens (human)0.0537

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bradley, KA; Damoiseaux, R; Gillespie, EJ; Huang, J; Manchester, M; Rogers, J; Sanchez, AM; Saxe, JP; Thomas, D1
Bruchas, MR; Chavkin, C; Gendron, L; Ippolito, DL; Xu, M1
Chai, JR; Chen, JC; Hu, XW; Li, M; Liu, JG; Liu, Y; Shu, XH; Wang, Q; Wang, YJ; Wu, X; Yang, CH; Zan, GY1
Al-Hasani, R; Bloodgood, DW; Bruchas, MR; Crowley, NA; Hardaway, JA; Kash, TL; Kendra, AM; Krashes, MJ; Lowell, BB; McCall, JG; McCall, NM; Schools, ZL; Whistler, JL; Yu, W1
Furbish, AB; Heinsbroek, JA; Peters, J1

Other Studies

5 other study(ies) available for sb 203580 and u-50488

ArticleYear
Amiodarone and bepridil inhibit anthrax toxin entry into host cells.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:7

    Topics: Amiodarone; Animals; Anthrax; Antigens, Bacterial; Bacterial Toxins; Bepridil; Cell Line; Cell Survival; Chloroquine; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Macrophages, Peritoneal; Male; Mice; Molecular Structure; Rats; Rats, Inbred F344; Time Factors

2007
Sciatic nerve ligation-induced proliferation of spinal cord astrocytes is mediated by kappa opioid activation of p38 mitogen-activated protein kinase.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, Mar-07, Volume: 27, Issue:10

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Astrocytes; Cell Proliferation; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Hyperalgesia; Hyperesthesia; Imidazoles; In Vitro Techniques; Ligation; Lumbar Vertebrae; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naltrexone; Narcotic Antagonists; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Opioid, kappa; Sciatic Nerve; Spinal Cord

2007
p38 mitogen-activated protein kinase activation in amygdala mediates κ opioid receptor agonist U50,488H-induced conditioned place aversion.
    Neuroscience, 2016, Apr-21, Volume: 320

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amygdala; Analgesics, Non-Narcotic; Animals; Conditioning, Operant; Enzyme Activation; Enzyme Inhibitors; Fluorescent Antibody Technique; Imidazoles; Immunoblotting; Male; Mice; Mice, Inbred C57BL; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Opioid, kappa

2016
Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit.
    Cell reports, 2016, Mar-29, Volume: 14, Issue:12

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amygdala; Animals; Anxiety; Behavior, Animal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Channelrhodopsins; Dynorphins; Evoked Potentials; Glutamic Acid; Imidazoles; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microscopy, Fluorescence; p38 Mitogen-Activated Protein Kinases; Patch-Clamp Techniques; Pyridines; Receptors, Opioid, kappa; Septal Nuclei

2016
A single, extinction-based treatment with a kappa opioid receptor agonist elicits a long-term reduction in cocaine relapse.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018, Volume: 43, Issue:7

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cues; Drug-Seeking Behavior; Extinction, Psychological; Imidazoles; Infusions, Intraventricular; Lithium Chloride; Male; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Receptors, Opioid, kappa; Recurrence; Self Administration

2018