sb 203580 and u 0126

Topics: Animals; Antiviral Agents; Drug Repositioning; Humans; Protein Kinase Inhibitors; Virus Diseases; Viruses

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides

Topics: beta-Lactamase Inhibitors; beta-Lactamases; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Biological; Phosphotransferases; Scattering, Radiation

Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera

Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

Topics: Animals; Apoptosis; Dioxoles; Heme Oxygenase-1; Hydrogen Peroxide; Lignans; NF-E2-Related Factor 2; PC12 Cells; Rats; Seedlings; Sesamum

Topics: Dose-Response Relationship, Drug; Fluorescence Resonance Energy Transfer; Glycolipids; Humans; Membrane Proteins; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Structure-Activity Relationship

Topics: Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Drug Approval; Drug Repositioning; High-Throughput Screening Assays; Humans; Protein Kinase Inhibitors; SARS-CoV-2; United States; United States Food and Drug Administration; Virus Diseases

Topics: Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Viral; Herpesvirus 4, Human; Humans; Imidazoles; Immediate-Early Proteins; Kinetics; MAP Kinase Signaling System; Nitriles; Promoter Regions, Genetic; Protein Kinase C; Pyridines; RNA, Messenger; Smad2 Protein; Smad3 Protein; Smad4 Protein; Smad7 Protein; Tetradecanoylphorbol Acetate; Trans-Activators; Transforming Growth Factor beta; Tumor Cells, Cultured; Viral Proteins

Topics: Butadienes; Cells, Cultured; Enzyme Inhibitors; Humans; Imidazoles; Immunoglobulin E; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mast Cells; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines

Topics: Animals; Basilar Artery; Butadienes; Dogs; Enzyme Inhibitors; Flavonoids; Genistein; Imidazoles; In Vitro Techniques; Magnesium; Magnesium Deficiency; Male; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth, Vascular; Nitriles; Phosphopeptides; Protein-Tyrosine Kinases; Pyridines

Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Butadienes; Carbazoles; Cell Nucleus; Cell Survival; Cells, Cultured; Cerebral Cortex; Cycloheximide; Dactinomycin; DNA Fragmentation; Drug Synergism; Embryo, Mammalian; Enzyme Inhibitors; Female; Imidazoles; Immunoglobulin G; Indole Alkaloids; Kinetics; Male; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; Nitric Oxide Donors; Nitriles; Nitroprusside; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Wistar; Receptor, trkB; Signal Transduction

Topics: Arachidonic Acid; Butadienes; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Interleukin-1; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; Time Factors; Tumor Cells, Cultured

Topics: Adolescent; Adult; Antigens, CD; Butadienes; Child; Child, Preschool; DNA-Binding Proteins; Enzyme Inhibitors; Female; Humans; Imidazoles; Infant; Integrin alpha6; Interferon-alpha; Interferon-gamma; Interleukin-12; Interleukin-18; Interleukin-18 Receptor alpha Subunit; Interleukin-4; Male; Mycobacterium avium-intracellulare Infection; Nitriles; Proto-Oncogene Proteins c-myc; Pyridines; Receptor, Interferon alpha-beta; Receptors, Interferon; Receptors, Interleukin; Receptors, Interleukin-12; Receptors, Interleukin-18; Salmonella Infections; Signal Transduction; STAT4 Transcription Factor; T-Lymphocytes; Th1 Cells; Trans-Activators

Topics: 3T3 Cells; Animals; Binding Sites; Bone Neoplasms; Butadienes; Cell Transformation, Neoplastic; Colony-Forming Units Assay; DNA; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genes, ras; Humans; Imidazoles; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutation; Nitriles; Oncogene Proteins, Fusion; Protein Serine-Threonine Kinases; Proto-Oncogene Protein c-fli-1; Pyridines; RNA-Binding Protein EWS; Sarcoma, Ewing; Transcription Factors; Tumor Cells, Cultured

Topics: Butadienes; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Maleimides; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinase 2; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; NADPH Dehydrogenase; NADPH Oxidases; Neutrophils; Nitriles; Peptide Mapping; Phosphopeptides; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Respiratory Burst

Topics: Arachidonate 5-Lipoxygenase; Butadienes; Calcimycin; Calcium; Cell-Free System; Enzyme Activation; Flavonoids; Humans; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitriles; Phosphorylation; Protein Serine-Threonine Kinases; Protein Transport; Protein-Tyrosine Kinases; Pyridines

Topics: Anisomycin; Blotting, Northern; Blotting, Western; Butadienes; Calcium; Cell Line; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Ionophores; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Monocytes; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Biosynthesis; Protein Synthesis Inhibitors; Pyridines; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Tumor Necrosis Factor-alpha

Topics: Apoptosis; Butadienes; Cadmium Chloride; Chelating Agents; Drug Interactions; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Ethylenediamines; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Pyridines; Tumor Cells, Cultured

Topics: Animals; Butadienes; Carotid Arteries; Cells, Cultured; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Imidazoles; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Nitriles; p38 Mitogen-Activated Protein Kinases; Platelet-Derived Growth Factor; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Transcription, Genetic; Tumor Necrosis Factor-alpha

Topics: Blotting, Western; Butadienes; DNA-Binding Proteins; eIF-2 Kinase; Enzyme Activation; HeLa Cells; Humans; Imidazoles; Interferon Regulatory Factor-1; Interferon-alpha; Interleukin-1; Interleukin-6; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Polynucleotides; Protein Serine-Threonine Kinases; Pyridines; RNA, Double-Stranded; RNA, Messenger; Transcriptional Activation

Topics: Adrenergic alpha-Agonists; Butadienes; Cell Count; Cell Division; Cell Line; DNA, Recombinant; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Plasmids; Pyridines; Receptors, Adrenergic, alpha-1; Transfection

Topics: Acetylcysteine; Amanitins; Aminoacetonitrile; Apoptosis; Benzoquinones; Bryostatins; Butadienes; Curcumin; Cysteine Endopeptidases; Dactinomycin; Diterpenes; Drug Synergism; Enzyme Activation; Flavonoids; Humans; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; Lactones; Macrolides; Maleimides; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Nitriles; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Kinase C; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-raf; Pyridines; Quinones; Terpenes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Type C Phospholipases; U937 Cells; Ubiquitins

Topics: Aggrecans; Animals; Butadienes; Cell Differentiation; Cell Line; Cell Nucleus; Chondrocytes; Cycloheximide; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Matrix Proteins; Gene Expression Regulation, Enzymologic; Genes, Dominant; Imidazoles; Immunoblotting; Lectins, C-Type; Luciferases; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Synthesis Inhibitors; Proteoglycans; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Smad Proteins; Thiazoles; Time Factors; Trans-Activators; Transcription, Genetic; Transfection; Transforming Growth Factor beta

Topics: Animals; Base Sequence; Butadienes; Cell Line; CHO Cells; Cricetinae; Enzyme Inhibitors; Enzyme Repression; Gene Expression Regulation, Enzymologic; Genes, Reporter; Imidazoles; Kinetics; Luciferases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Models, Biological; Molecular Sequence Data; Neurons; Nitriles; Promoter Regions, Genetic; Pyridines; Quinoxalines; Recombinant Proteins; Serotonin Receptor Agonists; Transcription, Genetic; Transfection; Tryptophan Hydroxylase

Topics: Animals; Benzylamines; Blotting, Western; Butadienes; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle Proteins; Circadian Rhythm; Cricetinae; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Flavonoids; Imidazoles; In Situ Hybridization; Light; Male; MAP Kinase Signaling System; Mesocricetus; Mitogen-Activated Protein Kinase Kinases; Motor Activity; Nerve Tissue Proteins; Nitriles; Nuclear Proteins; Period Circadian Proteins; Pyridines; RNA, Messenger; Sulfonamides; Suprachiasmatic Nucleus; Transcription Factors

Topics: Adjuvants, Immunologic; Animals; Antigen-Presenting Cells; Butadienes; Carrier Proteins; Cell Line; CpG Islands; Cytokines; Dendritic Cells; Down-Regulation; Enzyme Inhibitors; Imidazoles; Macrophages; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Nitriles; Oligodeoxyribonucleotides; Protein Biosynthesis; Proteins; Pyridines; Repressor Proteins; RNA, Messenger; Signal Transduction; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Transcription Factors

Topics: Adrenal Glands; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anisomycin; Antihypertensive Agents; Butadienes; Cattle; Chromaffin Cells; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Flavonoids; Imidazoles; Immunoblotting; Losartan; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Phosphoserine; Protein Synthesis Inhibitors; Pyridines; Receptors, Angiotensin; Time Factors; Tyrosine 3-Monooxygenase

Topics: Animals; Butadienes; Cell Differentiation; Culture Media, Serum-Free; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Genetic Vectors; Imidazoles; Immunoblotting; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Neurites; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitriles; PC12 Cells; Pyridines; ras Proteins; Rats

Topics: Animals; Aorta; Butadienes; Cell Line; Dose-Response Relationship, Drug; Endothelial Growth Factors; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lymphokines; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchi; Butadienes; Cytokines; Drug Evaluation, Preclinical; Eosinophils; Female; Flavonoids; Humans; Imidazoles; Lung Diseases, Obstructive; Male; MAP Kinase Kinase Kinase 1; Middle Aged; Mitogen-Activated Protein Kinases; Muscle, Smooth; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Up-Regulation

Topics: Anisomycin; Arsenites; Butadienes; Cadmium Chloride; Carcinogens; Dithiothreitol; Enzyme Inhibitors; Flavonoids; Glioma; Heat-Shock Proteins; Humans; Hydrogen Peroxide; Imidazoles; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Osmotic Pressure; Oxidants; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Synthesis Inhibitors; Pyridines; Sodium Compounds; Sorbitol; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

Topics: 1-Methyl-3-isobutylxanthine; Animals; Butadienes; CCAAT-Enhancer-Binding Proteins; Cell Fractionation; Cell Line; Colforsin; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; DNA; Enzyme Induction; Enzyme Inhibitors; Imidazoles; Isoenzymes; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Models, Biological; NF-kappa B; Nitriles; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Protein Binding; Pyridines; RNA, Messenger; Transcription Factors

Topics: Adenylyl Cyclases; Butadienes; Cell Division; Cells, Cultured; Cyclooxygenase 2; Enzyme Inhibitors; Epidermal Growth Factor; GTP-Binding Proteins; Humans; Imidazoles; Interleukin-1; Isoenzymes; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle, Smooth; Nitriles; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines; Receptors, Cell Surface; Trachea; Tumor Necrosis Factor-alpha

Topics: Antineoplastic Agents; Blotting, Western; Butadienes; Cross-Linking Reagents; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Imidazoles; Interleukin-13; Interleukin-13 Receptor alpha1 Subunit; Interleukin-4; Keratinocytes; Kinetics; Ligands; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Plasmids; Precipitin Tests; Protein Binding; Pyridines; Receptors, Interleukin; Receptors, Interleukin-13; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; STAT6 Transcription Factor; Time Factors; Trans-Activators; Transcription, Genetic; Tumor Cells, Cultured; Tyrphostins

Topics: Animals; Aorta; Apoptosis; Butadienes; Cattle; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Tumor Necrosis Factor-alpha

Topics: Adrenal Medulla; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzylamines; Butadienes; Cattle; Cells, Cultured; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Isoquinolines; Losartan; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Phosphoserine; Protein Processing, Post-Translational; Proto-Oncogene Proteins pp60(c-src); Pyridines; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Ribosomal Protein S6 Kinases; src-Family Kinases; Sulfonamides

Topics: 3T3 Cells; Alkaline Phosphatase; Animals; Butadienes; Cattle; Cell Differentiation; Cell Division; Culture Media; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; Nitriles; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Pyridines

Topics: Adipocytes; Animals; Butadienes; Cell Lineage; Embryo, Mammalian; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; Myocardium; Neurons; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Binding; Pyridines; Receptors, Cytoplasmic and Nuclear; RNA; Signal Transduction; Stem Cells; Time Factors; Transcription Factors; Tretinoin

Topics: Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Butadienes; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Kinetics; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; Osteoblasts; Osteocalcin; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines

Topics: Animals; Butadienes; Culture Techniques; Dimethyl Sulfoxide; Drug Synergism; Enzyme Inhibitors; Imidazoles; Methionine; Mitogen-Activated Protein Kinases; Neurites; Neurons; Neurotrophin 3; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; ras Proteins; Rats; Rats, Sprague-Dawley; Signal Transduction; Spiral Ganglion

Topics: Analysis of Variance; Animals; Butadienes; Calcium; Calcium Channel Blockers; Cell Line; Chelating Agents; Dinoprostone; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Gallic Acid; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Imidazoles; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Molecular Chaperones; Naphthalenes; Neoplasm Proteins; Nitriles; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Pyridines; Pyrrolidinones; Staurosporine; Stimulation, Chemical; Time Factors; Type C Phospholipases

Topics: Animals; Butadienes; Cells, Cultured; Imidazoles; Laminin; Methionine; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neurites; Neurons; Nitriles; Pyridines; ras Proteins; Rats; Signal Transduction; Spiral Ganglion

Topics: Animals; Brain Injuries; Butadienes; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Imidazoles; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Up-Regulation

Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Antineoplastic Agents, Phytogenic; Butadienes; Cell Line; Enzyme Inhibitors; Gene Expression; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Phosphorylation; Proteins; Pyridines; Serine; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Threonine; Tumor Necrosis Factor-alpha

Topics: Animals; Butadienes; Cells, Cultured; Cholesterol; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Imidazoles; Inhibitory Concentration 50; Mitogen-Activated Protein Kinases; Mutation; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Toxoplasma

Topics: Adrenergic Agonists; Adrenergic alpha-1 Receptor Agonists; Analysis of Variance; Animals; Butadienes; Endothelin-1; Enzyme Inhibitors; Flavonoids; Heart Rate; Imidazoles; Isoproterenol; Male; MAP Kinase Signaling System; Methoxamine; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Myocardial Contraction; Nitriles; Pyridines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1

Topics: Acetophenones; Androstadienes; Animals; Benzopyrans; Brefeldin A; Butadienes; Cell Communication; Cells, Cultured; Cricetinae; Cricetulus; Enzyme Inhibitors; Flavonoids; Gap Junctions; Imidazoles; Indoles; Maleimides; Mesocricetus; Mitogen-Activated Protein Kinases; Nitriles; Peroxisome Proliferators; Protein Kinase C; Protein Synthesis Inhibitors; Pyridines; Pyrimidines; Signal Transduction; Sirolimus; Wortmannin

Topics: Butadienes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fetal Hemoglobin; Gene Expression Regulation; Gene Expression Regulation, Leukemic; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; K562 Cells; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Pyridines; Valproic Acid

Topics: Animals; Butadienes; Carrier Proteins; Cell Differentiation; Cell Division; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Imidazoles; Immunoblotting; MAP Kinase Kinase Kinase 1; Membrane Glycoproteins; Mice; Mitogen-Activated Protein Kinases; Models, Biological; Monocytes; Nitriles; Osteoclasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Signal Transduction; Time Factors

Topics: Animals; Butadienes; Cells, Cultured; Curcumin; Enzyme Inhibitors; Female; Flavonoids; Gene Expression; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Muscle, Smooth; Myometrium; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pregnancy; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Uterine Contraction

Topics: Androstadienes; Butadienes; Cell Line; Chlorides; Epithelial Cells; Humans; Imidazoles; Indoles; Maleimides; Mitogen-Activated Protein Kinases; Nitriles; Nitrobenzenes; Phospholipases A; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Pyridines; Pyrimidines; Quinazolines; Receptor, PAR-1; Receptors, Thrombin; Signal Transduction; Sulfonamides; Thrombin; Tyrphostins; Wortmannin

Topics: Angiogenesis Inhibitors; Butadienes; Cellular Senescence; Chemokine CCL20; Chemokine CCL21; Chemokines, CC; Chemotaxis, Leukocyte; Chromones; Dendritic Cells; Enzyme Inhibitors; Humans; Imidazoles; Lipopolysaccharides; Macrophage Inflammatory Proteins; Mitogen-Activated Protein Kinases; Monocytes; Morpholines; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, CCR6; Receptors, CCR7; Receptors, Chemokine; Signal Transduction; Up-Regulation

Topics: Butadienes; Cell Differentiation; Cyclosporine; Enzyme Activation; Enzyme Inhibitors; Erythroid Precursor Cells; Hemoglobins; Humans; Imidazoles; K562 Cells; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines

Topics: Blotting, Western; Butadienes; Chemokine CCL2; Curcumin; Cytokines; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; Imidazoles; Immunoblotting; Interleukin-6; Kidney Tubules, Proximal; Mitogen-Activated Protein Kinases; Myeloma Proteins; NF-kappa B; Nitriles; Phosphorylation; Pyridines; Signal Transduction

Topics: Animals; Butadienes; Cell Line; Cell Nucleus; Enzyme Inhibitors; Escherichia coli; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Isoquinolines; L Cells; Mice; Mice, Mutant Strains; Mitogen-Activated Protein Kinases; Models, Biological; Mutation; NF-kappa B; Nitriles; Phosphorylation; Protein Subunits; Pyridines; Recombinant Proteins; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Sulfonamides; Transcriptional Activation; Tumor Necrosis Factor-alpha

Topics: Animals; Anisomycin; Anti-Bacterial Agents; Blotting, Western; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Butadienes; Cell Line; Chromones; Endothelial Growth Factors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Imidazoles; Intercellular Signaling Peptides and Proteins; Lymphokines; Mice; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Biosynthesis; Protein Synthesis Inhibitors; Proteins; Pyridines; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

Topics: Butadienes; Cell Degranulation; Chemokine CCL11; Chemokine CCL24; Chemokine CCL26; Chemokines, CC; Chemotactic Factors, Eosinophil; Enzyme Inhibitors; Eosinophil Peroxidase; Eosinophils; HL-60 Cells; Humans; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Peroxidases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines

Topics: Animals; BALB 3T3 Cells; Butadienes; Chromones; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Genes, Dominant; Imidazoles; Interleukin-1; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Signal Transduction; Transcription, Genetic

Topics: 3T3 Cells; Angiogenesis Inducing Agents; Animals; Butadienes; Dose-Response Relationship, Drug; Drug Synergism; Endothelial Growth Factors; Flavonoids; Imidazoles; Intercellular Signaling Peptides and Proteins; Lymphokines; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; Osteoblasts; Pyridines; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

Topics: Asthma; Blotting, Northern; Butadienes; Cells, Cultured; Chemokine CCL11; Chemokine CCL2; Chemokine CCL7; Chemokines; Chemokines, CC; Curcumin; Cytokines; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Immunoblotting; Interleukin-1; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Monocyte Chemoattractant Proteins; Muscle, Smooth; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Pyrrolidines; Stimulation, Chemical; Thiocarbamates

Topics: Androstadienes; Anthracenes; Apoptosis; Butadienes; Cell Survival; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Leukemic; HL-60 Cells; Humans; Hydrogen Peroxide; Imidazoles; Insulin-Like Growth Factor I; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Kinetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oxazoles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptor, IGF Type 1; RNA, Messenger; Wortmannin

Topics: Anthracenes; Basic Helix-Loop-Helix Transcription Factors; Butadienes; Cell Line, Tumor; Cell Proliferation; Culture Media; Culture Media, Serum-Free; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Silencing; Genetic Vectors; Growth Inhibitors; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Nitriles; Pancreatic Neoplasms; Proto-Oncogene Proteins c-raf; Pyridines; ras Proteins; Retroviridae; RNA, Antisense; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1

Topics: Adenosine Triphosphate; Butadienes; Cell Degranulation; Enzyme Activation; Enzyme Inhibitors; Fibrinogen; Humans; Imidazoles; Indoles; Lipoxygenase Inhibitors; Mitogen-Activated Protein Kinases; Neutrophils; Nitriles; Pancreatic Elastase; Pyrazoles; Pyridines; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Uridine Triphosphate

Topics: Animals; Butadienes; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Inhibitors; Erythropoietin; Flavonoids; Gene Expression Regulation, Neoplastic; Globins; Imidazoles; Immediate-Early Proteins; Leukemia, Erythroblastic, Acute; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Proto-Oncogene Proteins c-fos; Pyridines; Transcription Factors; Tumor Cells, Cultured

Topics: Acetyltransferases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butadienes; Butyrates; Cell Line; Cyclooxygenase 2; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Histone Acetyltransferases; Histones; Imidazoles; Isoenzymes; Lipopolysaccharides; Mice; NF-kappa B; Nitriles; Phosphorylation; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Pulmonary Alveoli; Pyridines; Transcriptional Activation

Topics: Apoptosis; Blotting, Western; Butadienes; Dexamethasone; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Glucocorticoids; Humans; Imidazoles; Leukemia, Plasma Cell; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Statistics, Nonparametric; Transcription Factor AP-1; Tumor Cells, Cultured; Tumor Necrosis Factor Receptor Superfamily, Member 7

Topics: Benzoquinones; Butadienes; Cells, Cultured; Chromones; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dental Pulp; Dexamethasone; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Isoenzymes; Lactams, Macrocyclic; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; NF-kappa B; Nitriles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Pyridines; Quinones; Rifabutin; Signal Transduction; Sulfonamides

Topics: 3' Untranslated Regions; Animals; Anisomycin; Anthracenes; Butadienes; Cell Line; Cricetinae; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Heterogeneous-Nuclear Ribonucleoproteins; Imidazoles; Mitogen-Activated Protein Kinase Kinases; Nitriles; Nucleic Acid Synthesis Inhibitors; Phosphatidylinositol 3-Kinases; Pyridines; Receptors, Adrenergic, beta; RNA Stability; Signal Transduction

Topics: Active Transport, Cell Nucleus; Adiponectin; Animals; Anti-Inflammatory Agents; Butadienes; Cytokines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Imidazoles; Intercellular Signaling Peptides and Proteins; Interleukin-10; Interleukin-6; Lipopolysaccharides; Macrophages; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Proteins; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Swine; Time Factors

Topics: Androstadienes; Animals; Aorta, Thoracic; Butadienes; Calcium; Carbazoles; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Indoles; Lanthanum; Male; Maleimides; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle Contraction; Myosin Light Chains; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Potassium Chloride; Protein Kinase C; Pyridines; Rats; Rats, Wistar; Thapsigargin; Urotensins; Verapamil; Wortmannin

Topics: Androstadienes; Butadienes; Cell Line; Enzyme Inhibitors; Gene Expression Regulation, Viral; Hepatitis B virus; Hepatocytes; Humans; Imidazoles; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Invasiveness; NF-kappa B; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Recombinant Fusion Proteins; Signal Transduction; Trans-Activators; Transcription, Genetic; Transfection; Viral Regulatory and Accessory Proteins; Wortmannin

Topics: Adolescent; Adult; Aged; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Proteins; Butadienes; Cells, Cultured; Enzyme Inhibitors; Female; Humans; Hypertension, Pulmonary; Imidazoles; Ligands; MAP Kinase Signaling System; Mitosis; Muscle, Smooth, Vascular; Nitriles; Protein Serine-Threonine Kinases; Pulmonary Artery; Pyridines; Receptors, Growth Factor; RNA, Messenger

Topics: Alprostadil; Analysis of Variance; Animals; Butadienes; Butanones; Cell Line; Cell Survival; Cyclooxygenase Inhibitors; Dinoprost; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Imidazoles; Interleukin-1; Matrix Metalloproteinase 1; Metalloendopeptidases; Nabumetone; Naphthaleneacetic Acids; NF-kappa B; Nitric Oxide; Nitriles; Phosphorylation; Prostaglandins E; Pyridines; Rabbits; Synovial Membrane; Tumor Necrosis Factor-alpha

Topics: Animals; Anthracenes; Butadienes; Cell Differentiation; Cell Line; Chondrocytes; Chondrogenesis; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Imidazoles; Insulin; Mice; Mitogen-Activated Protein Kinases; Nitriles; Pyridines; Signal Transduction

Topics: Alkaline Phosphatase; Animals; Anthracenes; Butadienes; Calcification, Physiologic; Cattle; Cell Differentiation; Cell Line; Cell Proliferation; DNA; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Imidazoles; JNK Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Nitriles; Osteogenesis; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Stress, Mechanical

Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Anthracenes; Aorta, Thoracic; Bacterial Proteins; Benzopyrans; Butadienes; Catheterization; Cell Division; Dipeptides; ErbB Receptors; Flavonoids; Glycine; Hydroxamic Acids; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; Organ Culture Techniques; Phenylephrine; Phosphorylation; Protein Processing, Post-Translational; Pyridines; Quinazolines; Rats; Receptors, Adrenergic, alpha-1; Thrombin; Tyrphostins

Topics: Animals; Anthracenes; Brain-Derived Neurotrophic Factor; Butadienes; Enzyme Activation; Ganglia, Spinal; Gene Expression Regulation; Hot Temperature; Hyperalgesia; Imidazoles; Ion Channels; JNK Mitogen-Activated Protein Kinases; Ligation; Lumbar Vertebrae; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons, Afferent; Nitriles; p38 Mitogen-Activated Protein Kinases; Physical Stimulation; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Rhizotomy; Spinal Nerves; Stress, Mechanical; TRPV Cation Channels

Topics: Aorta; Arteriosclerosis; Butadienes; Cell Division; Cells, Cultured; Chromones; Diabetes Complications; Hormones, Ectopic; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Recombinant Proteins; Resistin; Signal Transduction

Topics: Activating Transcription Factor 3; Animals; Antibodies; Behavior, Animal; Brain-Derived Neurotrophic Factor; Butadienes; Cell Count; Constriction; Drug Interactions; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Functional Laterality; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Imidazoles; Immunohistochemistry; In Situ Hybridization; Male; Nerve Growth Factor; Neurons; Neuropeptide Y; Nitriles; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Time Factors; Transcription Factors

Topics: Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Anthracenes; Blotting, Western; Butadienes; Cells, Cultured; Dose-Response Relationship, Drug; Drug Combinations; Extracellular Signal-Regulated MAP Kinases; Imidazoles; JNK Mitogen-Activated Protein Kinases; Microglia; Nitriles; Nitrites; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Time Factors

Topics: Animals; Anthracenes; Butadienes; Cell Death; Cell Hypoxia; Cell Line; Enzyme Activation; Guanidines; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Molecular Structure; Myocardium; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyrans; Pyridines; Reactive Oxygen Species

Topics: Actins; Actomyosin; Animals; Antineoplastic Agents; Butadienes; Capillary Permeability; Cattle; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Humans; Imidazoles; Lung; MAP Kinase Signaling System; Microtubules; Nitriles; Protein Kinases; Pyridines

Topics: Animals; Butadienes; Calcium; Cell-Free System; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Heterocyclic Compounds, 4 or More Rings; Imidazoles; Immunoblotting; Indoles; Maleimides; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Pyridines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Type C Phospholipases

Topics: Butadienes; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Humans; Imidazoles; Interleukin-8; Mitogen-Activated Protein Kinases; NF-kappa B; Nitriles; Phosphorylation; Pyocyanine; Pyridines; Signal Transduction

Topics: Animals; Apoptosis; Butadienes; Cell Line; Cell Survival; Culture Media, Serum-Free; Enzyme Activation; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines

Topics: Amyloid beta-Peptides; Animals; Apoptosis; Butadienes; Celecoxib; Cyclooxygenase 2; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Peptide Fragments; Poly(ADP-ribose) Polymerases; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Rats; Sulfonamides; Up-Regulation

Topics: Animals; Anthracenes; Blotting, Western; Butadienes; Butyric Acid; Cell Line, Tumor; Cell Movement; Chemotaxis; Chymases; Enzyme Inhibitors; Eosinophils; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mast Cells; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 3; Nitriles; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Pyridines; Receptors, G-Protein-Coupled; Serine Endopeptidases; Signal Transduction; Time Factors

Topics: Acetylcysteine; Anthracenes; Antioxidants; Apoptosis; Ascorbic Acid; Butadienes; Cell Line, Tumor; Cell Proliferation; DNA Damage; Enzyme Inhibitors; Fluoresceins; HeLa Cells; Humans; Imidazoles; MAP Kinase Signaling System; Melatonin; Mitochondria; Nitriles; Nitrites; Oxazines; Oxygen; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Radiation Tolerance; Rhodamines; Spectrometry, Fluorescence; Xanthenes

Topics: Acetylation; Alcohol Dehydrogenase; Animals; Anthracenes; Butadienes; Ethanol; Gene Expression Regulation, Enzymologic; Hepatocytes; Histone Acetyltransferases; Histones; Imidazoles; Male; MAP Kinase Signaling System; Nitriles; Pyridines; Rats; Rats, Sprague-Dawley

Topics: Animals; Bacterial Toxins; Bacteroides fragilis; Bacteroides Infections; Butadienes; Chemokine CCL2; Colon; Down-Regulation; Enteritis; HL-60 Cells; Humans; Imidazoles; Interleukin-8; Intestinal Mucosa; MAP Kinase Signaling System; Metalloendopeptidases; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Nitriles; Protein Kinase Inhibitors; Pyridines; Specific Pathogen-Free Organisms; Transcription Factor AP-1

Topics: Adenylyl Cyclase Inhibitors; Animals; Aorta; Bradykinin; Bradykinin B2 Receptor Antagonists; Butadienes; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 2; Dideoxyadenosine; Enzyme Induction; Imidazoles; Immunohistochemistry; Isoquinolines; Male; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Bradykinin B2; Sulfonamides

Topics: Animals; Blotting, Northern; Butadienes; Cells, Cultured; Cytochrome P-450 CYP2B1; Dichlororibofuranosylbenzimidazole; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Hepatocytes; Imidazoles; Luciferases, Firefly; Male; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutation; Nitriles; p38 Mitogen-Activated Protein Kinases; Phenobarbital; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection

Topics: Antigens, CD34; Butadienes; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fetal Blood; GC Rich Sequence; Gene Expression Regulation; Hematopoietic Stem Cells; Humans; Imidazoles; Interleukin-8; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; NF-kappa B; Nitriles; Oligodeoxyribonucleotides; Pyridines; Toll-Like Receptor 9

Topics: Anthracenes; Butadienes; Cells, Cultured; Cyclooxygenase 2; Endothelial Cells; Endothelium, Vascular; Gene Deletion; Humans; Imidazoles; MAP Kinase Kinase 4; Membrane Proteins; Neovascularization, Physiologic; Nitriles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; RNA, Small Interfering; Signal Transduction; Sulfonamides; Vascular Endothelial Growth Factor A

Topics: Butadienes; Caseins; Chromones; Dental Pulp; Enzyme Inhibitors; Humans; Imidazoles; Mitogen-Activated Protein Kinase Kinases; Morpholines; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Porphyromonas endodontalis; Pyridines; Signal Transduction; Tissue Plasminogen Activator; Up-Regulation

Topics: Animals; Anthracenes; Apoptosis; Butadienes; Calcineurin Inhibitors; Caspases; Cell Nucleus; Chromones; Cyclosporine; DNA Fragmentation; Enzyme Inhibitors; Fluorescent Dyes; Imidazoles; Indoles; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Morpholines; Myocardium; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Porphyromonas gingivalis; Pyridines; Rats

Topics: Adiponectin; Animals; Butadienes; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Drug Interactions; Enzyme Activation; Flavonoids; Imidazoles; Isoquinolines; Leptin; Macrophages, Peritoneal; Male; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 3; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Tumor Necrosis Factor-alpha

Topics: Apoptosis; Arsenic Trioxide; Arsenicals; Blotting, Western; Butadienes; Cell Survival; DNA; Enzyme Inhibitors; Flavonoids; Growth Inhibitors; Humans; Imidazoles; MAP Kinase Kinase 1; Nitriles; Oxides; p38 Mitogen-Activated Protein Kinases; Pyridines; Thymidine; Tissue Culture Techniques; Tumor Cells, Cultured

Topics: Anthracenes; Bile Duct Neoplasms; Butadienes; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromones; Clone Cells; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Gefitinib; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oncogene Protein v-akt; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Quinazolines; Radiation-Sensitizing Agents

Topics: Animals; Apoptosis; Butadienes; Cadmium Chloride; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Imidazoles; Male; Mitogen-Activated Protein Kinase 3; Nitriles; p38 Mitogen-Activated Protein Kinases; Pituitary Gland, Anterior; Pyridines; Random Allocation; Rats; Rats, Sprague-Dawley

Topics: Animals; Butadienes; Cell Line, Tumor; Chemokine CXCL2; Chemokines; Chymases; Cytokines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Eosinophils; Gene Expression; Humans; Imidazoles; Interleukin-8; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Neutrophils; Nitriles; Peritonitis; Pertussis Toxin; Pyridines; Quinazolines; RNA, Messenger; Serine Endopeptidases

Topics: Adolescent; Adult; Butadienes; Chromones; Fibroblasts; Flavonoids; Humans; Imidazoles; Interleukin-8; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Proteinase-Activated; Signal Transduction; Skin; STAT3 Transcription Factor; Thrombin; Tyrphostins

Topics: Animals; Butadienes; Cell Death; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Endothelial Cells; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; Mice; Mice, SCID; Mitogen-Activated Protein Kinase 14; Neoplasms; Nitriles; Pyridines; Structure-Activity Relationship; Thalidomide; Xenograft Model Antitumor Assays

Topics: Butadienes; Cells, Cultured; Chromones; Cyclooxygenase 1; Cyclooxygenase 2; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Immunoblotting; Lipoproteins, HDL; Lipoproteins, HDL3; Morpholines; Nitriles; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Time Factors

Topics: Animals; Arachidonic Acid; Butadienes; CHO Cells; Cricetinae; Cricetulus; Cytosol; Enzyme Activation; Enzyme Inhibitors; Group IV Phospholipases A2; GTP-Binding Protein alpha Subunits, G12-G13; Imidazoles; Marine Toxins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutation; Nitriles; Oxazoles; Phospholipases A; Phosphoric Monoester Hydrolases; Phosphorylation; Pyridines; Pyrrolidines; rhoA GTP-Binding Protein; Transfection

Topics: Butadienes; Caseins; Cell Line, Tumor; Chromones; Culture Media, Conditioned; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Imidazoles; Interleukin-1alpha; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Morpholines; Nitriles; Osteosarcoma; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Porphyromonas gingivalis; Pyridines; Tissue Plasminogen Activator; Up-Regulation

Topics: Animals; Anthracenes; Butadienes; Cell Line; Extracellular Signal-Regulated MAP Kinases; Histamine; Histidine Decarboxylase; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; RNA, Messenger

Topics: Apoptosis; Apoptosis Regulatory Proteins; Butadienes; Cell Line, Tumor; Dexamethasone; Enzyme Activation; Glucocorticoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Nitriles; Pyridines; Sensitivity and Specificity; Signal Transduction; T-Lymphocytes

Topics: Amino Acids, Essential; Androstadienes; Blotting, Western; Butadienes; Cell Line; Depression, Chemical; Enterocytes; Enzyme Activation; Glucagon-Like Peptide 1; Humans; Imidazoles; Meat; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Hydrolysates; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Statistics, Nonparametric; Wortmannin

Topics: Animals; Animals, Newborn; Blotting, Western; Butadienes; Cardiomegaly; Cells, Cultured; Cycloheximide; Dactinomycin; Dinoprostone; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Gene Silencing; Genistein; Imidazoles; Janus Kinases; Myocytes, Cardiac; Nitriles; Phosphorylation; Protein Synthesis Inhibitors; Pyridines; Rats; Rats, Wistar; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; RNA Interference; Signal Transduction; STAT3 Transcription Factor; Stress, Mechanical

Topics: Animals; Butadienes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Macrophages, Alveolar; Male; MAP Kinase Kinase 5; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 7; NADPH Oxidases; Nitriles; Onium Compounds; p38 Mitogen-Activated Protein Kinases; Particulate Matter; Pyridines; Rats; Rats, Inbred WKY; Reactive Oxygen Species; Soot; Tacrolimus

Topics: Animals; Butadienes; Calcium; Cattle; Chelating Agents; Chromones; Egtazic Acid; Extracellular Signal-Regulated MAP Kinases; Female; Hydrogen-Ion Concentration; Imidazoles; Indoles; Ionomycin; Maleimides; Morpholines; Neutrophils; Nitriles; p38 Mitogen-Activated Protein Kinases; Propionates; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; Sodium-Hydrogen Exchangers; Spectrometry, Fluorescence

Topics: alpha-Synuclein; Animals; Anthracenes; Blotting, Western; Butadienes; Chromones; Enzyme Inhibitors; Fibroblast Growth Factor 2; Gene Expression Regulation; Humans; Imidazoles; Introns; JNK Mitogen-Activated Protein Kinases; Models, Biological; Morpholines; Nerve Growth Factor; Nitriles; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic

Topics: Anthracenes; Arthritis, Rheumatoid; Blotting, Western; Butadienes; Case-Control Studies; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Humans; Imidazoles; MAP Kinase Kinase 4; Matrix Metalloproteinase 1; Matrix Metalloproteinase Inhibitors; Nitriles; Osteoarthritis; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Signal Transduction; Statistics, Nonparametric; Synovial Membrane; Tumor Necrosis Factor-alpha

Topics: Bacterial Proteins; Butadienes; Cell Line; Chaperonin 60; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation; Helicobacter pylori; Humans; Imidazoles; Interleukin-8; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Models, Biological; Monocytes; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; RNA, Messenger; RNA, Small Interfering; Toll-Like Receptor 2; Transcription, Genetic

Topics: Apoptosis; Butadienes; Carcinoma, Hepatocellular; CASP8 and FADD-Like Apoptosis Regulating Protein; Cathepsins; Cell Line, Tumor; Flavonoids; Humans; Imidazoles; Liver Neoplasms; Lysosomes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; p38 Mitogen-Activated Protein Kinases; Permeability; Protein Transport; Pyridines; TNF-Related Apoptosis-Inducing Ligand

Topics: Aldosterone; Anthracenes; Blotting, Western; Butadienes; Cells, Cultured; Dose-Response Relationship, Drug; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; Kidney Tubules, Proximal; Mifepristone; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Phosphorylation; Pyridines; Signal Transduction; Time Factors; Transforming Growth Factor beta1

Topics: 3T3 Cells; Anilides; Animals; Apoptosis; Blotting, Western; Butadienes; Caspase 3; Caspase Inhibitors; Cell Survival; Chromans; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Flow Cytometry; Hypoglycemic Agents; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mice; Mitogen-Activated Protein Kinases; Nitriles; Osteoblasts; PPAR gamma; Pyridines; Reactive Oxygen Species; Thiazolidinediones; Troglitazone

Topics: Animals; Anthracenes; Bone Marrow Cells; Butadienes; Chromones; Dendritic Cells; Gene Expression; Gene Expression Regulation, Enzymologic; Imidazoles; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Janus Kinase 1; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Male; Mice; Mice, Inbred Strains; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyridines

Topics: Blotting, Western; Butadienes; Cells, Cultured; Coumarins; Cyclic AMP; Cyclooxygenase 2; Female; Gene Expression; Humans; I-kappa B Kinase; Imidazoles; Interleukin-1beta; Labor Onset; Membrane Proteins; Microscopy, Confocal; Mitogen-Activated Protein Kinase 3; Myocytes, Smooth Muscle; Myometrium; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Pregnancy; Pyridines; Receptors, Corticotropin-Releasing Hormone; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction

Topics: Animals; Antibodies; Butadienes; Cell Division; Cell Survival; Cyclosporine; Dextrans; Dogs; Electric Impedance; Enzyme Inhibitors; Epithelial Cells; Fluorescein-5-isothiocyanate; Imidazoles; Immunosuppressive Agents; Kidney; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Protein Serine-Threonine Kinases; Pyridines; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Tight Junctions; Transforming Growth Factor beta1

Topics: Anthracenes; Anthrax; Bacillus anthracis; Butadienes; Chemokines; Cytokines; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Gene Expression Regulation; Humans; Imidazoles; Immunity, Innate; Immunohistochemistry; In Vitro Techniques; Lung; Macrophages, Alveolar; MAP Kinase Signaling System; Microscopy, Fluorescence; Nitriles; Pulmonary Alveoli; Pyridines; RNA, Messenger; Spores, Bacterial

Topics: Animals; Bone Marrow Cells; Butadienes; Cell Differentiation; Cells, Cultured; Chemokine CCL3; Chromones; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Imidazoles; Mice; Morpholines; Nitriles; Oncogene Protein v-akt; Osteoblasts; Osteoclasts; Phosphatidylinositol 3-Kinases; Phosphorylation; Pyridines; RANK Ligand; Signal Transduction; Stromal Cells

Topics: Animals; Biological Transport; Blotting, Northern; Blotting, Western; Butadienes; Endotoxemia; Galactose; Imidazoles; Intestinal Mucosa; Intestines; Lipopolysaccharides; Male; Mitogen-Activated Protein Kinases; Nitriles; Protein Kinase C; Pyridines; Rabbits; Sodium-Glucose Transporter 1

Topics: Animals; Butadienes; Cells, Cultured; Chromones; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation; Imidazoles; Interleukin-12; Interleukin-4; Mast Cells; Mice; Morpholines; Nitriles; Proto-Oncogene Proteins c-akt; Pyridines; Receptors, Proteinase-Activated; RNA, Messenger; Trypsin; Tryptases; Tyrphostins

Topics: Animals; Apoptosis; Blotting, Western; Butadienes; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Early Growth Response Protein 1; Epithelial Cells; ets-Domain Protein Elk-1; HCT116 Cells; HT29 Cells; Humans; Imidazoles; Intestinal Mucosa; Intestines; Luciferases; Microscopy, Confocal; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sulindac; Transfection; Up-Regulation

Topics: Butadienes; Chemotaxis, Leukocyte; Dose-Response Relationship, Immunologic; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; Lipopolysaccharides; Lipoproteins; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Activating Factor; Pyridines; Toll-Like Receptors

Topics: Blotting, Western; Butadienes; Cell Line; Cell Proliferation; Cell Survival; Collagen Type I; Dose-Response Relationship, Drug; Extracellular Matrix; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Humans; Imidazoles; MAP Kinase Signaling System; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Piperidines; Protein Synthesis Inhibitors; Pyridines; Quinazolinones; Time Factors

Topics: Acetylcysteine; Activating Transcription Factor 2; Animals; Antioxidants; Brain; Butadienes; Buthionine Sulfoximine; Glutathione; Imidazoles; Kidney; Liver; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; NF-E2-Related Factor 2; NF-kappa B; Nitriles; Oxidative Stress; Proto-Oncogene Proteins c-jun; Pyridines; Reactive Oxygen Species; Sulfhydryl Compounds

Topics: Blotting, Western; Butadienes; Calcium; Cell Line; Extracellular Space; Flavonoids; Humans; Imidazoles; Immunoprecipitation; Kidney Tubules, Proximal; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Calcitriol; Receptors, Calcium-Sensing; RNA, Small Interfering; Signal Transduction

Topics: Actins; Animals; Animals, Newborn; Atrial Natriuretic Factor; Blotting, Western; Butadienes; Cell Enlargement; Cell Size; Cells, Cultured; Dinoprostone; Gene Expression; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Naphthalenes; Natriuretic Peptide, Brain; Nitriles; Phenylbutyrates; Phosphorylation; Prostaglandin Antagonists; Protein Biosynthesis; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Reverse Transcriptase Polymerase Chain Reaction

Topics: Animals; Anthracenes; Butadienes; CD40 Antigens; Cell Line; Cell Line, Tumor; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Flow Cytometry; Humans; Imidazoles; Immunoblotting; Leupeptins; Mitogen-Activated Protein Kinases; Monocytes; NF-kappa B; Nitriles; Phosphorylation; Polysaccharides, Bacterial; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Sulfones; Time Factors; Toll-Like Receptor 4

Topics: Amylases; Animals; Anthracenes; Aquaporin 5; Butadienes; Cell Adhesion; Cell Culture Techniques; Cell Differentiation; Cell Proliferation; Cell Shape; Cells, Cultured; Claudin-4; Claudins; Enzyme Activation; Extracellular Matrix; Imidazoles; Keratin-14; Male; Membrane Proteins; Nitriles; p38 Mitogen-Activated Protein Kinases; Parotid Gland; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Pyrimidines; Rats; Rats, Sprague-Dawley; Signal Transduction; src-Family Kinases; Tight Junctions; Time Factors; Vimentin

Topics: Butadienes; Cell Line, Tumor; DNA; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Nitriles; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Pyridines; Tumor Necrosis Factor-alpha; Urinary Bladder Neoplasms

Topics: Amides; Anesthetics, Local; Animals; Anthracenes; Bupivacaine; Butadienes; Cell Size; Cell Survival; Cells, Cultured; Cytoprotection; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Ganglia, Spinal; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lidocaine; Membrane Potentials; Mitogen-Activated Protein Kinases; Neurons, Afferent; Nitriles; p38 Mitogen-Activated Protein Kinases; Phenotype; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Ropivacaine; Sodium Channels

Topics: Butadienes; Cell Line; Cell Shape; Cyclosporine; Enzyme Activation; Epithelial Cells; Fibronectins; Fibrosis; Green Fluorescent Proteins; Humans; Imidazoles; Isoenzymes; Kidney Tubules, Proximal; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Phenotype; Protein Kinase C; Protein Kinase C beta; Pyridines; Pyrones; Recombinant Fusion Proteins; Signal Transduction; Transforming Growth Factor beta1

Topics: Animals; Bee Venoms; Butadienes; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Hyperalgesia; Hypersensitivity; Imidazoles; Immunohistochemistry; Inflammation; Male; Mitogen-Activated Protein Kinase 3; Nitriles; p38 Mitogen-Activated Protein Kinases; Pain Threshold; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord

Topics: Animals; Anthracenes; Butadienes; Cells, Cultured; Early Growth Response Protein 1; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Imidazoles; MAP Kinase Kinase 4; Mechanotransduction, Cellular; Mice; Nitriles; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Protein Kinase Inhibitors; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection

Topics: Adenosine Triphosphate; Animals; Blotting, Western; Butadienes; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Imidazoles; Injections, Spinal; Male; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Pain; Pain Measurement; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord

Topics: Adiponectin; Animals; Butadienes; Embryonic Development; Female; Flavonoids; Imidazoles; Immunohistochemistry; Male; MAP Kinase Signaling System; Meiosis; Mitogen-Activated Protein Kinases; Nitriles; Oocytes; Parthenogenesis; Pregnancy; Protein Kinase Inhibitors; Pyridines; Receptors, Adiponectin; Reverse Transcriptase Polymerase Chain Reaction; RNA; Swine

Topics: Anthracenes; Butadienes; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Extracellular Signal-Regulated MAP Kinases; Hepatocytes; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Pharmaceutical Preparations; Pyridines; Receptors, Aryl Hydrocarbon

Topics: Animals; Anthracenes; Astrocytes; Butadienes; Cells, Cultured; Cerebral Cortex; Chemokine CXCL1; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Imidazoles; Immunochemistry; Mitogen-Activated Protein Kinases; N-Methylaspartate; Neurons; Nitriles; Pyridines; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors

Topics: Anthracenes; Apoptosis; Butadienes; Capillaries; Extracellular Signal-Regulated MAP Kinases; Glycation End Products, Advanced; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipoproteins, LDL; MAP Kinase Signaling System; Nitriles; p38 Mitogen-Activated Protein Kinases; Pericytes; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Retinal Vessels; Time Factors

Topics: Anthracenes; Butadienes; Cell Line; Cell Movement; Chemokine CCL2; Chemokine CCL5; Collagen; Culture Media, Conditioned; Drug Combinations; Enzyme Inhibitors; Female; Humans; Imidazoles; In Vitro Techniques; Laminin; Macrophages; MAP Kinase Signaling System; Monocytes; Nitriles; Pregnancy; Proteoglycans; Pyridines; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Trophoblasts; Tumor Necrosis Factor-alpha

Topics: Androstadienes; Animals; Aorta; Blotting, Western; Butadienes; Calcimycin; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Dideoxyadenosine; Endothelial Cells; Imidazoles; Ionophores; Mitogen-Activated Protein Kinase 3; Nitric Oxide; Nitriles; Oncogene Protein v-akt; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Peptides, Cyclic; Pyridines; Signal Transduction; Swine; Urocortins; Wortmannin

Topics: Aggregatibacter actinomycetemcomitans; Animals; Anti-Infective Agents; Butadienes; Calcification, Physiologic; Cell Line; Cell Survival; Cyclooxygenase 1; Cyclooxygenase 2; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escherichia coli; Imidazoles; Interleukin-6; Lipid A; Lipopolysaccharides; Membrane Proteins; Mitogen-Activated Protein Kinases; Nitriles; Odontoblasts; Oxidants, Photochemical; Ozone; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Tumor Necrosis Factor-alpha

Topics: Acetophenones; Benzopyrans; Butadienes; Chromones; Gene Expression Regulation, Enzymologic; Genistein; Hexosaminidases; Humans; Imidazoles; Macrophages; MAP Kinase Signaling System; Monocytes; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphorylation; Prolactin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; RNA, Messenger; Tyrphostins

Topics: Anthracenes; Aroclors; Butadienes; Cyclosporine; Environmental Pollutants; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Luminescent Measurements; NADPH Oxidases; Neutrophil Activation; Neutrophils; Nitriles; Pyridines; Respiratory Burst; Tacrolimus

Topics: Adrenergic alpha-Agonists; Animals; Aorta, Abdominal; Butadienes; Disease Models, Animal; Enzyme Inhibitors; Hindlimb Suspension; HSP27 Heat-Shock Proteins; Imidazoles; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitriles; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Phorbol 12,13-Dibutyrate; Pyridines; Rats; Rats, Wistar; Signal Transduction

Topics: Animals; Butadienes; CD4-Positive T-Lymphocytes; Cell Proliferation; Cell Survival; Cytokines; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Gene Silencing; Imidazoles; Interleukin-2 Receptor alpha Subunit; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Myeloid Differentiation Factor 88; NF-kappa B; Nitriles; Peptides; Porins; Pyridines; Receptors, Chemokine; RNA, Small Interfering; Shigella dysenteriae; Toll-Like Receptor 2

Topics: 3T3 Cells; Animals; Anthracenes; Butadienes; Cells, Cultured; Chromones; Dose-Response Relationship, Drug; Imidazoles; Mice; Morpholines; Naphthalenes; Nitriles; Osteoblasts; Phosphates; Prostaglandin D2; Pyridines; Signal Transduction; Sirolimus; Sodium

Topics: Anthracenes; Butadienes; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Imidazoles; Lactones; MAP Kinase Kinase Kinases; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Quinazolines; Resorcinols; RNA, Small Interfering; Serine; Signal Transduction; Threonine; Tumor Necrosis Factor-alpha

Topics: Animals; Antioxidants; Butadienes; Carotenoids; Cell Line; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; I-kappa B Kinase; Imidazoles; Interleukin-6; Lipopolysaccharides; Lycopene; Macrophages; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Nitric Oxide; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Signal Transduction; Tumor Necrosis Factor-alpha

Topics: Animals; Butadienes; Carcinoembryonic Antigen; Cell Line; Coronavirus Infections; Enzyme Inhibitors; Fibroblasts; Heparitin Sulfate; Hepatitis, Animal; Imidazoles; Interleukin-6; Liver; Macrophages, Peritoneal; Membrane Glycoproteins; Mice; Mice, Knockout; Murine hepatitis virus; NF-kappaB-Inducing Kinase; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Spike Glycoprotein, Coronavirus; Toll-Like Receptor 2; Tumor Necrosis Factor-alpha; Viral Envelope Proteins; Virus Replication

Topics: Acute Disease; Animals; Butadienes; Carcinoembryonic Antigen; Cell Line; Cells, Cultured; Enzyme Inhibitors; Fibroblasts; Hepatitis, Viral, Animal; Imidazoles; Interferon-gamma; Interleukin-12; Interleukin-18; Killer Cells, Natural; Leukocytes, Mononuclear; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase Kinases; Murine hepatitis virus; Nitriles; Pyridines; Recombinant Proteins

Topics: Animals; Anthracenes; Bacterial Outer Membrane Proteins; Butadienes; Cell Adhesion Molecules; Cell Survival; Cronobacter sakazakii; Dendritic Cells; Enterobacteriaceae Infections; Enzyme Inhibitors; Epithelial Cells; Flavonoids; HeLa Cells; Humans; Imidazoles; Interleukin-10; Lectins, C-Type; Lipopolysaccharides; Lymphocyte Activation; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Mitogen-Activated Protein Kinase Kinases; Nitriles; Pyridines; Rats; Receptors, Cell Surface; Transfection; Transforming Growth Factor beta

Topics: Animals; Anthracenes; Astragalus Plant; Astragalus propinquus; Blotting, Western; Butadienes; Cell Line; Cell Movement; Cell Proliferation; Cell Survival; Cyclin A; Cyclin D1; Cyclin E; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Inhibitors; Fibroblast Growth Factor 2; Imidazoles; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 3; Models, Biological; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Schwann Cells; Urokinase-Type Plasminogen Activator

Topics: Animals; Apoptosis; Butadienes; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cells, Cultured; Hydrogen Peroxide; Imidazoles; Lymph Nodes; Lymphocytes; Lymphoma, T-Cell; Male; Mice; Mice, Inbred C3H; Mitogen-Activated Protein Kinase Kinases; Necrosis; NF-kappa B; Nitric Oxide; Nitriles; Nitrites; omega-N-Methylarginine; p38 Mitogen-Activated Protein Kinases; Peroxidase; Protein Kinase Inhibitors; Pyridines; Superoxide Dismutase; Superoxides

Topics: 3T3 Cells; Alkaline Phosphatase; Animals; Butadienes; Cell Differentiation; Cell Proliferation; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Halitosis; Humans; Hydrogen Sulfide; Imidazoles; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines

Topics: Acetylation; Animals; Butadienes; Cell Line; Core Binding Factor Alpha 1 Subunit; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblast Growth Factor 2; Humans; Imidazoles; Immunoblotting; Immunoprecipitation; Mutation; Nitriles; Phosphorylation; Protein Stability; Pyridines; Serine; Transfection; Ubiquitin; Ubiquitination

Topics: Butadienes; Colon; Cycloheximide; Estradiol; Estrogen Receptor beta; Fulvestrant; Humans; Imidazoles; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitriles; Phytoestrogens; Pyridines; Reproducibility of Results; Tissue Survival

Topics: Animals; Anthracenes; Blotting, Western; Butadienes; Cell Death; Cells, Cultured; Deferoxamine; Dose-Response Relationship, Drug; Hydrogen Peroxide; Imidazoles; Iron Chelating Agents; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Retinal Pigment Epithelium; Swine; Trypan Blue

Topics: Analysis of Variance; Animals; Animals, Newborn; Astrocytes; Butadienes; Cell Death; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Hippocampus; Imidazoles; Mitogen-Activated Protein Kinases; Neurons; Nitriles; Oligopeptides; Organ Culture Techniques; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, PAR-2; Trypsin

Topics: Butadienes; Chromones; Down-Regulation; Humans; Imidazoles; Interleukin-1beta; Interleukins; Macrophage-1 Antigen; Morpholines; Neutrophils; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Pyridines; Receptors, Formyl Peptide; Signal Transduction; Up-Regulation

Topics: Adult; Areca; Blotting, Western; Butadienes; Calcium; Cell Survival; Cells, Cultured; Chelating Agents; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Imidazoles; Inflammation Mediators; Male; Neutrophils; Nitriles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Plant Extracts; Pyridines; Sulfonamides; Young Adult

Topics: Androstadienes; Animals; Anthracenes; Arteries; Butadienes; Caveolin 1; Cell Movement; Cells, Cultured; CSK Tyrosine-Protein Kinase; Electrophoresis, Polyacrylamide Gel; Endothelial Cells; Enzyme Inhibitors; Female; Focal Adhesion Protein-Tyrosine Kinases; Imidazoles; Immunoprecipitation; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitric Oxide Synthase Type III; Nitriles; Nitrogen Oxides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Placenta; Pregnancy; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Sheep; Signal Transduction; src-Family Kinases; Vascular Endothelial Growth Factor A; Wortmannin

Topics: Base Sequence; Blotting, Western; Butadienes; Cathepsin L; Cell Line; DNA Primers; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Mutation; Nitriles; p38 Mitogen-Activated Protein Kinases; Polymerase Chain Reaction; Protein Kinase Inhibitors; Pyridines; ras Proteins; Signal Transduction

Topics: Alkaline Phosphatase; Butadienes; Cell Differentiation; Cells, Cultured; Growth Differentiation Factor 5; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Ligamentum Flavum; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Osteocalcin; Osteogenesis; p38 Mitogen-Activated Protein Kinases; Pyridines; Recombinant Proteins

Topics: Blotting, Western; Butadienes; Cardiovirus Infections; Encephalomyocarditis virus; Enzyme Inhibitors; HeLa Cells; Humans; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Nuclear Pore Complex Proteins; p38 Mitogen-Activated Protein Kinases; Phosphopeptides; Phosphorylation; Protein Biosynthesis; Pyridines; Viral Proteins

Topics: Adiponectin; Animals; Butadienes; C-Reactive Protein; Glucose Clamp Technique; Humans; Imidazoles; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Interleukin-6; Leptin; Liver; Male; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Tumor Necrosis Factor-alpha

Topics: Animals; Butadienes; Cell Differentiation; Cell Line; Embryoid Bodies; Embryonic Stem Cells; Endothelin-1; Enzyme Inhibitors; Imidazoles; Immunohistochemistry; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction

Topics: Animals; Blotting, Western; Butadienes; Cell Line; Chemokine CCL3; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Imidazoles; Interferon Regulatory Factor-3; Interferon-beta; Mice; Mitogen-Activated Protein Kinase Kinases; Nitriles; Osteoclasts; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-fos; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction

Topics: Animals; Antibodies, Monoclonal; Butadienes; CD28 Antigens; CD3 Complex; Cell Line, Tumor; Cells, Cultured; Enzyme Assays; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Glucose; Glycolysis; Hexokinase; Imidazoles; Lymphocyte Activation; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes

Topics: Animals; Blotting, Western; Butadienes; Cell Line; Cytokines; Electrophoretic Mobility Shift Assay; Enzyme Activation; Imidazoles; Macrophages; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Mycoplasma hyopneumoniae; NF-kappa B; Nitric Oxide; Nitriles; Phosphorylation; Pneumonia of Swine, Mycoplasmal; Protein Kinase Inhibitors; Pyridines; Pyrrolidines; Swine; Thiocarbamates

Topics: Action Potentials; Anesthetics, Inhalation; Animals; Butadienes; CA1 Region, Hippocampal; Cell Hypoxia; Electrophysiology; Extracellular Signal-Regulated MAP Kinases; Glucose; Imidazoles; Methyl Ethers; Neuroprotective Agents; Nitriles; Organ Culture Techniques; Oxygen; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Sevoflurane; Time Factors

Topics: Blotting, Western; Butadienes; Caco-2 Cells; Chromones; Humans; Imidazoles; Interferon-gamma; Intestinal Mucosa; Lacticaseibacillus casei; Membrane Proteins; Microscopy, Confocal; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Phosphoproteins; Probiotics; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Toll-Like Receptor 2; Tumor Necrosis Factor-alpha; Zonula Occludens-1 Protein

Topics: Butadienes; Cell Line; Chondrocytes; Drug Antagonism; Enzyme Inhibitors; Gene Expression; Humans; Hydrogen Sulfide; Imidazoles; Interleukin-1beta; Interleukin-6; Interleukin-8; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines

Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Anthracenes; Butadienes; Cells, Cultured; Humans; Imidazoles; Lipopolysaccharides; Macrophages; Monocytes; Nitriles; p38 Mitogen-Activated Protein Kinases; Phospholipases A2; Phosphorylation; Pyridines; RNA, Messenger; Simvastatin

Topics: Adaptor Proteins, Signal Transducing; Antigens; Blotting, Western; Butadienes; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Dendritic Cells; Discs Large Homolog 1 Protein; Enterotoxins; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; Interferon-gamma; Lymphocyte Activation; Membrane Proteins; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes

Topics: Angiotensin II; Anthracenes; Butadienes; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Gene Expression Profiling; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gq-G11; HEK293 Cells; Humans; Imidazoles; MicroRNAs; Myocytes, Cardiac; Nitriles; Pyridines; Receptor, Angiotensin, Type 1; Signal Transduction

Topics: Animals; Butadienes; CD8-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Flow Cytometry; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation; Imidazoles; Immunoblotting; Interleukin-7; Male; MAP Kinase Kinase Kinases; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Nitriles; Protein Binding; Pyridines; Receptors, Interleukin-7; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes

Topics: Adrenergic alpha-Antagonists; Animals; Anthracenes; Butadienes; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Nitriles; Norepinephrine; p38 Mitogen-Activated Protein Kinases; Phentolamine; Phosphorylation; Pyridines; Receptors, Adrenergic, alpha; Tumor Necrosis Factor-alpha

Topics: Acetylcysteine; Animals; Blotting, Western; Butadienes; Catalase; Cell Line; Fluorescent Antibody Technique; Glutathione; HEK293 Cells; Herpesviridae Infections; Herpesvirus 8, Human; Humans; Hydrogen Peroxide; Imidazoles; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred NOD; Mice, SCID; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Sarcoma, Kaposi; Signal Transduction; Virus Activation; Virus Latency; Virus Replication

Topics: Animals; Animals, Newborn; Anthracenes; Brain Injuries; Butadienes; Drug Interactions; Female; Imidazoles; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; N-Methylaspartate; Nitriles; Oligopeptides; Papaverine; Peptides; Pia Mater; Pyridines; Swine; Tissue Plasminogen Activator; Up-Regulation; Vasoconstriction; Vasodilation

Topics: Amyloid beta-Peptides; Anthracenes; Butadienes; Cell Line; Humans; Imidazoles; Inflammation; Interleukin-1 Receptor-Like 1 Protein; Interleukin-1beta; Interleukin-33; Interleukin-6; Interleukin-8; Interleukins; JNK Mitogen-Activated Protein Kinases; Macular Degeneration; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Nitriles; Peptide Fragments; Pyridines; Receptors, Cell Surface; Retinal Pigment Epithelium; Sulfones; Tumor Necrosis Factor-alpha

Topics: Butadienes; Cell Line, Tumor; Cell Survival; Enzyme-Linked Immunosorbent Assay; Female; Flavonoids; Humans; Imidazoles; Immunoblotting; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-E2-Related Factor 2; Nitriles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pre-Eclampsia; Pregnancy; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Vascular Endothelial Growth Factor A

Topics: Blotting, Western; Butadienes; Cell Line; Dose-Response Relationship, Drug; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Imidazoles; Matrix Metalloproteinase 9; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Trophoblasts

Topics: Acute Lung Injury; Anthracenes; Butadienes; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Endothelial Cells; Humans; Imidazoles; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Lung; MAP Kinase Signaling System; Methyl Ethers; Microvessels; Naphthalenes; Neutrophils; Nitriles; p38 Mitogen-Activated Protein Kinases; Phenylbutyrates; Pyridines; Receptors, Prostaglandin E, EP4 Subtype; Respiratory Distress Syndrome; RNA, Messenger; Thionucleotides

Topics: Animals; Antineoplastic Agents; Butadienes; Cardiomegaly; Cells, Cultured; Collagen; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Humans; Imidazoles; Interleukin-6; Male; MAP Kinase Signaling System; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Wistar; STAT1 Transcription Factor; STAT3 Transcription Factor; Vidarabine

Topics: Apoptosis; Blotting, Western; Butadienes; Cytomegalovirus; Cytomegalovirus Infections; DNA Primers; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation; Genetic Vectors; Humans; Imidazoles; Lentivirus; Myeloid Cell Leukemia Sequence 1 Protein; Myeloid Cells; Nitriles; Proto-Oncogene Proteins c-bcl-2; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Viral Envelope Proteins; Virus Internalization

Topics: Animals; Butadienes; Cell Cycle; Cell Line; Dactinomycin; Dual Specificity Phosphatase 1; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Imidazoles; MAP Kinase Kinase 4; Mice; Microtubules; Nitriles; Nocodazole; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; RNA; Signal Transduction; Tubulin; Tumor Necrosis Factor-alpha

Topics: 5' Untranslated Regions; Aniline Compounds; Animals; Butadienes; Cell Line, Tumor; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Genes, myc; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Mice; Multiple Myeloma; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Biosynthesis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-myc; Purines; Pyridines; RNA Interference; RNA, Messenger; RNA, Small Interfering; Sirolimus; TOR Serine-Threonine Kinases; Up-Regulation

Topics: Animals; Anthracenes; Blotting, Western; Butadienes; Cell Line; Decorin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; I-kappa B Kinase; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Luciferases; Luminescent Agents; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Myeloid Differentiation Factor 88; NF-kappa B p50 Subunit; Nitriles; Odontoblasts; p38 Mitogen-Activated Protein Kinases; Pyridines; Real-Time Polymerase Chain Reaction; Time Factors; Toll-Like Receptor 2; Toll-Like Receptor 4; Up-Regulation

Topics: Allergens; Animals; Blotting, Western; Butadienes; Cell Line, Tumor; Chromones; Cockroaches; Down-Regulation; Flavonoids; Flow Cytometry; Gene Expression Regulation; Imidazoles; Insect Proteins; Interleukin-12; MAP Kinase Signaling System; Mast Cells; Mice; Morpholines; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Pyridines; Recombinant Proteins; RNA, Messenger; Time Factors; Toll-Like Receptor 9

Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Butadienes; Caspases; Catalase; Cell Line, Tumor; Cell Proliferation; Cell Shape; Cell Survival; Disulfides; Extracellular Signal-Regulated MAP Kinases; Glioblastoma; Humans; Imidazoles; MAP Kinase Signaling System; Nitriles; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Pyridines; Sulfinic Acids

Topics: Amnion; Butadienes; Cell Line; Enzyme Inhibitors; Fumonisins; Humans; Imidazoles; Interleukin 1 Receptor Antagonist Protein; Interleukin-1alpha; Interleukin-8; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Pyridines; Sphingosine; Tumor Necrosis Factor-alpha

Topics: Acetylcholine; Animals; Anthracenes; Biomarkers; Butadienes; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Ileum; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Male; Mitogen-Activated Protein Kinases; Muscle Contraction; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Rabbits

Topics: Acetylcysteine; Antioxidants; ATP-Binding Cassette Transporters; Butadienes; Cell Line, Tumor; DNA-Binding Proteins; Humans; Hydrogen Peroxide; Imidazoles; Janus Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Protein B; Pulmonary Surfactant-Associated Protein D; Pyridines; RNA, Messenger; Signal Transduction; STAT3 Transcription Factor; Transcription Factors; Tyrphostins

Topics: 12E7 Antigen; Anthracenes; Antibodies, Monoclonal; Antigens, CD; Butadienes; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Culture Media, Conditioned; Endothelial Cells; Enzyme Inhibitors; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flow Cytometry; Gingiva; Humans; Imidazoles; Intercellular Adhesion Molecule-1; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Leukocytes; Leupeptins; MAP Kinase Signaling System; NF-kappa B; NF-kappa B p50 Subunit; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines

Topics: Adult; Butadienes; Carcinoma; Carcinoma, Papillary; Cell Line, Tumor; Child; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Immunohistochemistry; Iodide Peroxidase; Male; MAP Kinase Signaling System; Middle Aged; Mutation; Nitriles; Proto-Oncogene Proteins B-raf; Pyridines; Retrospective Studies; Thyroid Cancer, Papillary; Thyroid Neoplasms; Transforming Growth Factor beta1; Young Adult

Topics: Anthracenes; Butadienes; Cartilage, Articular; Cells, Cultured; Chondrocytes; Curcumin; Endopeptidases; Gene Expression Regulation; Humans; Imidazoles; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Lipoxygenases; Masoprocol; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Pyrrolidines; RNA, Messenger; Thiocarbamates; Transcription Factor AP-1

Topics: Animals; Anthracenes; Butadienes; Diabetes Mellitus, Type 2; Extracellular Signal-Regulated MAP Kinases; Imidazoles; Immunoblotting; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mitogen-Activated Protein Kinases; Nitriles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Leptin; Resveratrol; Signal Transduction; Stilbenes; Superoxides

Topics: Alkaline Phosphatase; Butadienes; Cell Differentiation; Cell Line; Collagen Type I; Core Binding Factor Alpha 1 Subunit; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; MAP Kinase Signaling System; Nitriles; Oligodeoxyribonucleotides; Osteoblasts; Osteocalcin; p38 Mitogen-Activated Protein Kinases; Pyridines; Transcriptional Activation

Topics: Animals; Butadienes; Calcification, Physiologic; Cell Differentiation; Down-Regulation; Dual Specificity Phosphatase 1; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Imidazoles; Male; Mice; Mice, Knockout; Nitriles; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Parathyroid Hormone; Phosphorylation; Pyridines

Topics: Analysis of Variance; Androstadienes; Animals; Blotting, Western; Butadienes; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Flavonoids; Glycation End Products, Advanced; Imidazoles; Intermediate-Conductance Calcium-Activated Potassium Channels; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; Patch-Clamp Techniques; Pyridines; Rats; RNA Interference; RNA, Small Interfering; Serum Albumin, Bovine; Signal Transduction; Wortmannin

Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Butadienes; Cell Line; Dopamine Agonists; Dopamine Antagonists; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Hydrogen Peroxide; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mice; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Rats; Receptors, Dopamine D1; Retinal Ganglion Cells; Signal Transduction

Topics: Acetylcysteine; Animals; Anthracenes; Aorta; Butadienes; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Imidazoles; Inula; Male; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-E2-Related Factor 2; Nitriles; Platelet-Derived Growth Factor; Pyridines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sesquiterpenes

Topics: Anthracenes; Butadienes; C-Reactive Protein; Cell Line; Cytokines; Gene Expression; Humans; Imidazoles; Inflammation Mediators; Interferon-gamma; Interleukin-1beta; MAP Kinase Signaling System; NF-kappa B; Nitriles; Pyridines; Retinal Pigment Epithelium; RNA, Messenger; Serum Amyloid P-Component; Signal Transduction; Sulfones; Tumor Necrosis Factor-alpha

Topics: Adult; Animals; Antigen-Antibody Complex; Autoantibodies; Butadienes; Dermis; Disease Models, Animal; Enzyme Inhibitors; Epidermal Cells; Epidermis; Epidermolysis Bullosa Acquisita; Glucocorticoids; Humans; Imidazoles; MAP Kinase Signaling System; Methylprednisolone; Mice; Mice, Inbred C57BL; Neutrophils; Nitriles; Pemphigoid, Bullous; Pyridines; Reactive Oxygen Species; Respiratory Burst

Topics: Anthracenes; Benzylamines; Butadienes; Cell Movement; Cell- and Tissue-Based Therapy; Cells, Cultured; Chemokine CXCL12; Cyclams; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Heterocyclic Compounds; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mesenchymal Stem Cells; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, CXCR4; Stress, Mechanical; Wound Healing

Topics: Acetylcysteine; Animals; Anthracenes; Apoptosis; Butadienes; Cadmium; Cell Line; Extracellular Signal-Regulated MAP Kinases; Glutathione Peroxidase; Imidazoles; JNK Mitogen-Activated Protein Kinases; Malondialdehyde; Mitogen-Activated Protein Kinases; Nitriles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase

Topics: Adult; Aluminum Compounds; Anthracenes; Butadienes; Calcium; Calcium Channel Blockers; Calcium Compounds; Cell Culture Techniques; Cell Differentiation; Cell Proliferation; Cells, Cultured; Culture Media; Dental Pulp; Drug Combinations; Extracellular Matrix Proteins; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Nifedipine; Nitriles; Odontoblasts; Oxides; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Pyridines; Root Canal Filling Materials; Sialoglycoproteins; Silicates; Tooth Calcification

Topics: Animals; Apoptosis Regulatory Proteins; Butadienes; Cell Line; Cell Transformation, Neoplastic; Cobalt; Disease Models, Animal; Enzyme Inhibitors; Epidermis; Hydrogen Peroxide; Imidazoles; In Vitro Techniques; MAP Kinase Signaling System; Mice; MicroRNAs; Mitogen-Activated Protein Kinase Kinases; Nanoparticles; Nitriles; Occupational Exposure; Pyridines; Reactive Oxygen Species; RNA-Binding Proteins; Signal Transduction; Tungsten Compounds

Topics: Adamantane; Animals; Butadienes; CA1 Region, Hippocampal; Calcium; Discrimination, Psychological; Extracellular Signal-Regulated MAP Kinases; Imidazoles; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; ras-GRF1; Receptors, AMPA; RNA Interference; Signal Transduction; Time Factors

Topics: Animals; Butadienes; Cell Shape; Cell Survival; Chromones; Hydrogen Peroxide; Imidazoles; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Signal Transduction; Sus scrofa; Time Factors; Time-Lapse Imaging; Trabecular Meshwork

Topics: Biomarkers; Butadienes; Cell Adhesion; Cyclopentanes; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Janus Kinase 2; Lipoproteins, HDL; Lipoproteins, VLDL; Mitogen-Activated Protein Kinases; Neutrophil Activation; Neutrophils; Nitriles; Phagocytes; Pyridines; Scavenger Receptors, Class B; Thiosemicarbazones; Tyrphostins

Topics: Acetylcysteine; Animals; Anthracenes; Apoptosis; Butadienes; Cell Line; Cell Survival; Enzyme Inhibitors; Flavanones; Fruit; Glucose; Hyperglycemia; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Nitriles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plant Extracts; Pyridines; Rats; Reactive Oxygen Species

Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Butadienes; Caenorhabditis elegans Proteins; Dietary Fats; Extracellular Signal-Regulated MAP Kinases; Fibronectins; Imidazoles; Male; MAP Kinase Signaling System; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mitochondrial Uncoupling Proteins; Mutation; Nitriles; p38 Mitogen-Activated Protein Kinases; Pichia; Protein Binding; Pyridines; Rats; Rats, Sprague-Dawley; Recombinant Proteins

Topics: Antineoplastic Agents; Butadienes; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Chemoradiotherapy; Dasatinib; Drug Screening Assays, Antitumor; Head and Neck Neoplasms; Humans; Imidazoles; Isoxazoles; Leflunomide; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Nitriles; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Radiation Tolerance; STAT5 Transcription Factor; STAT6 Transcription Factor; Thiazoles; Tumor Suppressor Proteins

Topics: beta-Defensins; Butadienes; Camellia sinensis; Catechin; Cell Line; Cell Survival; Enzyme Inhibitors; Epithelial Cells; Gingiva; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; p38 Mitogen-Activated Protein Kinases; Plant Extracts; Porphyromonas gingivalis; Proteolysis; Pyridines; Up-Regulation

Topics: Adipocytes; Adipogenesis; Amides; Butadienes; Cells, Cultured; Cytochalasin D; Cytoskeleton; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Protein-Tyrosine Kinases; Humans; Imidazoles; Mesenchymal Stem Cells; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Quinolones; rho-Associated Kinases; rhoA GTP-Binding Protein; Sulfones

Topics: Animals; Butadienes; Cell Movement; Cell Proliferation; Chromones; Ectoderm; Female; Gene Expression Regulation; Imidazoles; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pregnancy; Primary Cell Culture; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Receptor, IGF Type 1; Ribosomal Protein S6; RNA, Messenger; Signal Transduction; Swine; Trophoblasts

Topics: Adult; Bite Force; Bone Morphogenetic Protein 2; Butadienes; Calcification, Physiologic; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Humans; Imidazoles; Male; Mastication; Molar, Third; Nitriles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Stress, Physiological; Sulfonamides; Up-Regulation; Young Adult

Topics: Animals; Anti-Inflammatory Agents; Butadienes; Cell Line; Cyclooxygenase 2; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Gardenia; Imidazoles; Inflammation Mediators; Interleukin-6; Iridoids; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred Strains; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Nitriles; Pyridines; Signal Transduction; Sulfones; Transcription Factor AP-1; Tumor Necrosis Factor-alpha

Topics: Amides; Animals; Aorta; Atherosclerosis; Becaplermin; Butadienes; Cell Line; Cell Movement; Gene Expression Regulation; Humans; Imidazoles; Matrix Metalloproteinase 2; Muscle, Smooth, Vascular; Nitriles; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-sis; Pyridines; Rats; rho-Associated Kinases

Topics: Butadienes; CA-125 Antigen; Cells, Cultured; Cytokines; Epithelial Cells; Humans; Imidazoles; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mucin 5AC; Mucin-4; Mucin-5B; Nasal Mucosa; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Thymic Stromal Lymphopoietin

Topics: Anthracenes; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Butadienes; Cell Survival; Cells, Cultured; Cytochromes c; Enzyme Inhibitors; Fibroblasts; Gingiva; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Membrane Potentials; Mitochondria; Nitric Oxide; Nitriles; Nitroprusside; Pyridines; Signal Transduction

Topics: Adolescent; Adult; Alkaline Phosphatase; Anthracenes; Benzylamines; Butadienes; Calcium Compounds; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Culture Techniques; Cell Differentiation; Dental Pulp; Extracellular Matrix Proteins; Humans; Imidazoles; Integrin-Binding Sialoprotein; MAP Kinase Signaling System; NF-kappa B; Nitriles; Odontoblasts; Osteocalcin; Phosphoproteins; Protein Kinase Inhibitors; Pulp Capping and Pulpectomy Agents; Pyridines; Pyrrolidines; Sialoglycoproteins; Signal Transduction; Silicates; Stem Cells; Sulfonamides; Thiocarbamates; Young Adult

Topics: Aminopyrine; Antigen-Antibody Complex; Antioxidants; Ascorbic Acid; Autoimmune Diseases; Butadienes; CD11a Antigen; CD18 Antigens; Cell Degranulation; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; GPI-Linked Proteins; Humans; Imidazoles; Inflammation; Intracellular Signaling Peptides and Proteins; Lymphocyte Function-Associated Antigen-1; Macrophage-1 Antigen; Mesalamine; Neutrophil Activation; Neutrophils; Nitriles; Onium Compounds; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; Reactive Oxygen Species; Receptors, IgG; src-Family Kinases; Syk Kinase

Topics: Adolescent; Adult; Anthracenes; Benzylamines; Butadienes; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Chemokine CXCL12; Chemotactic Factors; Cyclams; Dental Pulp; Escherichia coli; Extracellular Signal-Regulated MAP Kinases; Heterocyclic Compounds; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; MAP Kinase Signaling System; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Pyrrolidines; Receptors, CXCR4; Signal Transduction; Stem Cells; Thiocarbamates; Young Adult

Topics: Actin Cytoskeleton; Adolescent; Adult; Alkaline Phosphatase; Biomechanical Phenomena; Butadienes; Calcification, Physiologic; Calcium; Cell Differentiation; Cell Shape; Cell Survival; Cells, Cultured; Child; Collagen Type I; Female; Humans; Hydrodynamics; Imidazoles; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Osteogenesis; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Pyridines; Stress, Mechanical; Young Adult

Topics: Animals; Anthracenes; Butadienes; Extracellular Signal-Regulated MAP Kinases; Imidazoles; Intestinal Secretions; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Membrane Potentials; Mice; Muscarinic Agonists; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines

Topics: Acetylcholinesterase; Animals; Butadienes; Cell Differentiation; Chromaffin Cells; Imidazoles; Indoles; Neurites; Neurogenesis; Neurons; Nitriles; PC12 Cells; Protein Kinase Inhibitors; Pyridines; Rats; Receptor, trkA; Signal Transduction; Temperature

Topics: Butadienes; Calcium; Calcium Channel Blockers; Cell Adhesion; Cell Differentiation; Dose-Response Relationship, Drug; Flavonoids; Gallic Acid; Gene Expression Regulation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imidazoles; Interleukin-13; Leukocyte Elastase; Macrophages; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Monocytes; Naphthalenes; Nitriles; p38 Mitogen-Activated Protein Kinases; Primary Cell Culture; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Receptor, PAR-2; Signal Transduction

Topics: Animals; Apoptosis; Blotting, Western; Butadienes; Cell Proliferation; Cell Survival; Cells, Cultured; Cytokines; Enzyme Inhibitors; Fas-Associated Death Domain Protein; Humans; Imidazoles; Leukocytes, Mononuclear; Lymphokines; MAP Kinase Signaling System; Mice; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Phosphorylation; Pyridines; Recombinant Proteins; STAT3 Transcription Factor

Topics: Blotting, Western; Butadienes; Cells, Cultured; Colon; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression; Humans; Imidazoles; Interleukin-1; Interleukin-1beta; Microscopy, Confocal; Myofibroblasts; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Transcription Factor AP-1; Transcription Factor RelA; Tumor Necrosis Factor-alpha

Topics: Animals; Anthracenes; Astrocytes; Butadienes; Cyclooxygenase 2; Dinoprostone; Imidazoles; Inflammation Mediators; Lipopolysaccharides; Mice; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type II; Nitriles; Primary Cell Culture; Protein Deglycase DJ-1; Pyridines; Tumor Necrosis Factor-alpha

Topics: Alveolar Epithelial Cells; Animals; Antioxidants; Butadienes; Cyclic N-Oxides; Free Radicals; Humans; Imidazoles; Inflammation; MAP Kinase Signaling System; Nitriles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Reactive Oxygen Species; Serotonin; Smoking; Spin Labels; Tandem Mass Spectrometry

Topics: Animals; Butadienes; Cell Adhesion; Cell Line, Tumor; Embryo Implantation; Endometrium; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Imidazoles; Integrin beta3; Leukemia Inhibitory Factor; Male; Mice; Mice, Inbred C57BL; Nitriles; p38 Mitogen-Activated Protein Kinases; Paeonia; Plant Extracts; Pyridines; RNA Interference; RNA, Small Interfering; Trophoblasts

Topics: Antiviral Agents; Aquatic Organisms; Butadienes; DNA Replication; DNA, Viral; Hep G2 Cells; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Imidazoles; Interferon-beta; Lamivudine; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Polysaccharides; Protein Kinase Inhibitors; Pyridines; RNA, Viral; Sulfones; Virus Replication

Topics: Anti-Inflammatory Agents; Artemisinins; Butadienes; Cell Adhesion; Cell Line; Coculture Techniques; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Intercellular Adhesion Molecule-1; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Monocytes; NF-kappa B; Nitriles; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Sulfones; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1

Topics: Anthracenes; Butadienes; Cell Adhesion; Cells, Cultured; Endometrium; Female; Humans; Imidazoles; Integrin beta Chains; Leukemia Inhibitory Factor; Leukemia Inhibitory Factor Receptor alpha Subunit; MAP Kinase Signaling System; Nitriles; Perilla frutescens; Plant Extracts; Plant Leaves; Plant Roots; Pyridines; RNA, Small Interfering; Signal Transduction

Topics: Butadienes; Cell Line; Cells, Cultured; Epithelial Cells; Escherichia coli; Extracellular Vesicles; Humans; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mucin 5AC; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Staphylococcus aureus

Topics: Anthracenes; Atherosclerosis; Basigin; Butadienes; Chromones; Flow Cytometry; Foam Cells; Gene Expression Regulation; Gene Silencing; Humans; Imidazoles; Lipoproteins, LDL; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Signal Transduction; U937 Cells; Up-Regulation; Vascular Endothelial Growth Factor A

Topics: Adaptor Proteins, Signal Transducing; Animals; Anthracenes; Apoptosis Regulatory Proteins; Brain; Brain Ischemia; Butadienes; Extracellular Signal-Regulated MAP Kinases; Imidazoles; Inflammasomes; Mice; Neurons; NF-kappa B; Nitriles; NLR Family, Pyrin Domain-Containing 3 Protein; Pyridines; Signal Transduction; Stroke; Sulfones

Topics: Acetylation; Animals; Butadienes; Cell Differentiation; Flavonoids; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Imidazoles; MAP Kinase Signaling System; Membrane Proteins; Mice; Models, Biological; Muscle Development; Muscle Fibers, Skeletal; Myosin Heavy Chains; Nitriles; Nuclear Proteins; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Stem Cells; Theophylline

Topics: Animals; Butadienes; Cell Differentiation; Cell Line; Cell Proliferation; Imidazoles; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myosin Heavy Chains; Nitriles; Osteocalcin; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-akt; Pyridines; Receptors, G-Protein-Coupled; RNA Interference; RNA, Small Interfering

Topics: Butadienes; Chlamydia trachomatis; Cytokines; Enzyme Inhibitors; Humans; Imidazoles; Inflammation; Interleukin-10; Interleukin-6; Interleukin-8; Leukocytes, Mononuclear; Mitogen-Activated Protein Kinase 1; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyrazoles; Pyridines; Pyrimidines; Real-Time Polymerase Chain Reaction; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha; Up-Regulation

Topics: Analysis of Variance; Antineoplastic Agents; Apoptosis; Butadienes; Cell Line, Tumor; Cell Proliferation; Chromones; Drug Synergism; Enzyme Inhibitors; Female; G1 Phase; Humans; Imidazoles; Isoflavones; MAP Kinase Signaling System; Matrix Metalloproteinases; Membrane Potential, Mitochondrial; Morpholines; Nitriles; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Reactive Oxygen Species; Resting Phase, Cell Cycle; Signal Transduction

Topics: Butadienes; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Survival; Down-Regulation; Humans; Imidazoles; Matrix Metalloproteinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mouth Neoplasms; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Stilbenes

Topics: Anthracenes; Autocrine Communication; Axitinib; Butadienes; Flavonoids; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Indazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 4; Membrane Proteins; Nitriles; Phosphatidylinositol 3-Kinases; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; RNA, Small Interfering; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

Topics: Butadienes; Cell Line; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; Interleukin-1; Isoquinolines; Keratinocytes; Nitriles; Plant Extracts; Pyridines; Pyrroles; Smad3 Protein; Up-Regulation

Topics: Animals; Butadienes; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Chromatin; Chromatin Assembly and Disassembly; Core Binding Factor Alpha 3 Subunit; Cyclin-Dependent Kinase 4; Drosophila melanogaster; Epithelial Cells; Gene Expression Regulation; HEK293 Cells; Histone-Lysine N-Methyltransferase; Humans; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 4; Myeloid-Lymphoid Leukemia Protein; Nitriles; p38 Mitogen-Activated Protein Kinases; Piperazines; Polycomb-Group Proteins; Protein Kinase Inhibitors; Pyridines; ras Proteins; RNA, Small Interfering; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

Topics: Acetates; Alkaloids; Animals; Anthracenes; Axin Protein; Benzopyrans; Butadienes; Cell Line; Cell Movement; Cell Proliferation; Cytoskeletal Proteins; Gene Expression Regulation; Gene Knockdown Techniques; Gene Silencing; Imidazoles; Matrix Metalloproteinase 2; Mice; Mitomycin; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; Pyridines

Topics: Animals; Anthracenes; Butadienes; Cell Survival; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Imidazoles; Mice; Mitogen-Activated Protein Kinase Kinases; Neurodegenerative Diseases; Neurons; Nitriles; Oxidative Stress; PC12 Cells; Primary Cell Culture; Pyridines; Rats; Reactive Oxygen Species

Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Butadienes; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Female; Humans; Imidazoles; MAP Kinase Signaling System; MCF-7 Cells; Melanthiaceae; Nitriles; Pyridines; Rhodamine 123; Saponins

Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Butadienes; Cell Line, Transformed; Cell Proliferation; Dexamethasone; Imidazoles; Kidney; Macrophages; Nitriles; Porcine Reproductive and Respiratory Syndrome; Porcine respiratory and reproductive syndrome virus; Pyridines; Receptors, Cell Surface; Sialic Acid Binding Ig-like Lectin 1; Swine

Topics: Animals; Anthracenes; Autophagy; Butadienes; Disease Models, Animal; Imidazoles; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Osteoarthritis; Protein Kinase Inhibitors; Pyridines; Rabbits; Severity of Illness Index

Topics: Animals; Axons; Butadienes; Disease Models, Animal; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Imidazoles; Male; Mice, Inbred C57BL; Nerve Regeneration; Neuralgia; Nitriles; p38 Mitogen-Activated Protein Kinases; Peripheral Nerve Injuries; Pyridines; Recovery of Function; Sciatic Nerve; Treatment Outcome