Page last updated: 2024-09-05

sb 203580 and thalidomide

sb 203580 has been researched along with thalidomide in 5 studies

Compound Research Comparison

Studies
(sb 203580)
Trials
(sb 203580)
Recent Studies (post-2010)
(sb 203580)
Studies
(thalidomide)
Trials
(thalidomide)
Recent Studies (post-2010) (thalidomide)
3,48941,1379,7891,3854,342

Protein Interaction Comparison

ProteinTaxonomysb 203580 (IC50)thalidomide (IC50)
Cereblon isoform 4Magnetospirillum gryphiswaldense7.8
Prostaglandin G/H synthase 1Ovis aries (sheep)0.37
Prostaglandin G/H synthase 2Ovis aries (sheep)0.5
DNA damage-binding protein 1Homo sapiens (human)1.38
Protein cereblonHomo sapiens (human)1.38

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H1
Abrahamsen, MS; Maheswaran, SK; Malazdrewich, C; Thumbikat, P1
Dennis, PA; Figg, WD; Lepper, ER; Warfel, NA; Zhang, C1
Jin, SH; Kim, TI; Kim, WH; Yang, KM1
Ge, YX; Li, YY; Liu, XG; Liu, YL; Wei, XH; Wu, CY; Xin, WJ; Xu, JT; Zang, Y; Zhang, T1

Other Studies

5 other study(ies) available for sb 203580 and thalidomide

ArticleYear
Identifying off-target effects and hidden phenotypes of drugs in human cells.
    Nature chemical biology, 2006, Volume: 2, Issue:6

    Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

2006
Pharmacological inhibition of Mannheimia haemolytica lipopolysaccharide and leukotoxin-induced cytokine expression in bovine alveolar macrophages.
    Microbial pathogenesis, 2004, Volume: 36, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Cattle; Cells, Cultured; Cytokines; Dexamethasone; Exotoxins; Gene Expression Regulation; Imidazoles; Interleukin-1; Interleukin-8; Lipopolysaccharides; Macrophages, Alveolar; Mannheimia haemolytica; Pentoxifylline; Pyridines; RNA, Messenger; Rolipram; Tetrahydropapaveroline; Thalidomide; Tumor Necrosis Factor-alpha

2004
Importance of the stress kinase p38alpha in mediating the direct cytotoxic effects of the thalidomide analogue, CPS49, in cancer cells and endothelial cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Jun-01, Volume: 12, Issue:11 Pt 1

    Topics: Animals; Butadienes; Cell Death; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Endothelial Cells; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; Mice; Mice, SCID; Mitogen-Activated Protein Kinase 14; Neoplasms; Nitriles; Pyridines; Structure-Activity Relationship; Thalidomide; Xenograft Model Antitumor Assays

2006
Thalidomide destabilizes cyclooxygenase-2 mRNA by inhibiting p38 mitogen-activated protein kinase and cytoplasmic shuttling of HuR.
    European journal of pharmacology, 2007, Mar-08, Volume: 558, Issue:1-3

    Topics: Antigens, Surface; Caco-2 Cells; Cyclooxygenase 2; Cytoplasm; ELAV Proteins; ELAV-Like Protein 1; Humans; Imidazoles; Interleukin-1beta; p38 Mitogen-Activated Protein Kinases; Protein Transport; Pyridines; RNA Stability; RNA-Binding Proteins; Thalidomide

2007
p38 activation in uninjured primary afferent neurons and in spinal microglia contributes to the development of neuropathic pain induced by selective motor fiber injury.
    Experimental neurology, 2007, Volume: 204, Issue:1

    Topics: Animals; Denervation; Enzyme Activation; Enzyme Inhibitors; Ganglia, Spinal; Hyperalgesia; Hypesthesia; Imidazoles; Immunohistochemistry; Lumbosacral Region; Male; Microglia; Motor Neurons; Nerve Fibers; Neuralgia; Neurons, Afferent; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Nerve Roots; Thalidomide; Time Factors; Tumor Necrosis Factor-alpha

2007