sb 203580 has been researched along with tetradecanoylphorbol acetate in 67 studies
| Studies (sb 203580) | Trials (sb 203580) | Recent Studies (post-2010) (sb 203580) | Studies (tetradecanoylphorbol acetate) | Trials (tetradecanoylphorbol acetate) | Recent Studies (post-2010) (tetradecanoylphorbol acetate) |
|---|---|---|---|---|---|
| 3,489 | 4 | 1,137 | 31,050 | 61 | 2,217 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (23.88) | 18.2507 |
| 2000's | 49 (73.13) | 29.6817 |
| 2010's | 2 (2.99) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Engel, K; Gaestel, M; Lee, JC; Rogalla, T; Schultz, H | 1 |
| Engel, K; Gaestel, M; Schultz, H | 1 |
| Boyd, D; Goepfert, H; Simon, C | 1 |
| Baines, IA; Cooper, JA; Flynn, A; Proud, CG; Vries, RG; Wang, X; Waskiewicz, AJ; Webb, BL | 1 |
| Clerk, A; Lazou, A; Sugden, PH | 1 |
| Delling, M; Gercken, G; Marti, T; Radloff, M | 1 |
| Nagarkatti, DS; Sha'afi, RI | 1 |
| Flory, E; Grosse-Wilde, A; Hoffmeyer, A; Kunz, M; Ludwig, S; Neufeld, B; Rapp, UR | 1 |
| Burns, CJ; Howell, SL; Jones, PM; Persaud, SJ | 1 |
| Clifton, AD; Cohen, P; Lal, AS; Rouse, J; Segal, AW | 1 |
| Bowden, GT; Gupta, A; Rosenberger, SF | 1 |
| Matthews, JS; O'Neill, LA | 1 |
| Kozawa, O; Miwa, M; Tokuda, H; Uematsu, T | 1 |
| Barnes, PJ; Giembycz, MA; Hellewell, PG; Lindsay, MA; Lynch, OT | 1 |
| Behrens, MM; Choi, DW; Gwag, BJ; Koh, JY; Strasser, U | 1 |
| Ezumi, Y; Hirai, K; Nishida, E; Takayama, H; Uchiyama, T | 1 |
| Alessi, DR; Fahlman, R; Krook, A; Ryder, JW; Wallberg-Henriksson, H; Zierath, JR | 1 |
| Ito, H; Ito, T; Kato, K; Kozawa, O; Matsuno, H; Niwa, M; Sakai, N; Tanabe, K; Uematsu, T | 1 |
| Hirasawa, N; Kobayashi, Y; Murakami, A; Ohuchi, K; Oikawa, S; Shiraishi, M | 1 |
| Cochet, C; Fahmi, H; Hmama, Z; Joab, I; Opolon, P | 1 |
| Hatakeyama, D; Kawamura, H; Kozawa, O; Matsuno, H; Uematsu, T | 1 |
| Davis, HW; Zhao, Y | 1 |
| Brodbeck, K; Häring, HU; Pfeiffer, A; Sauer, U; Schleicher, ED; Weigert, C | 1 |
| Hazzalin, CA; Mahadevan, LC; Rutault, K | 1 |
| Bosmann, M; Chang, JH; Hellmuth, M; Huwiler, A; Mühl, H; Ninic, R; Nold, M; Paulukat, J; Pfeilschifter, J | 1 |
| Azuma, N; Chen, EL; Gahtan, V; Ikeda, M; Kito, H; Nakajima, N; Sumpio, BE; Wang, X | 1 |
| Andersson, K; Sundler, R | 1 |
| Chan, JS; Chen, X; Filep, JG; Ingelfinger, JR; Tang, SS; Zhang, SL | 1 |
| Buttgereit, P; Haier, B; Kube, D; Tesch, H; Vockerodt, M | 1 |
| Grant, S; Vrana, JA | 1 |
| Kanda, Y; Kuroki, Y; Mizuno, K; Nishio, E; Watanabe, Y | 1 |
| Fong, WF; Lam, W; Leung, CH; Wong, NS; Yang, MS; Zhuang, WJ | 1 |
| Inaguma, Y; Ito, H; Iwamoto, I; Kato, K; Lida, K | 1 |
| Biffl, WL; Ciesla, DJ; Gonzalez, RJ; Moore, EE; Moore, HB; Silliman, CC | 1 |
| Chung, HT; Kim, NY; Kim, YM; Lee, HS; Oh, GS; Oh, H; Pae, HO; Shin, MK; Yun, YG | 1 |
| Brunelleschi, S; Colangelo, D; Gaudino, G; Lavagno, L; Penengo, L; Santoro, C; Viano, I | 1 |
| Maher, P | 1 |
| Kim, EG; Min, DS; Shin, EY | 1 |
| Hong, SI; Hur, JH; Kim, MS; Lee, HC; Lee, KH; Lee, SH; Park, IC; Park, MJ; Rhee, CH; Woo, SH | 1 |
| Ho, YS; Lee, WS; Liang, YC; Lin, SY; Pan, S; Tsai, SH | 1 |
| Hong, SI; Hong, YJ; Kuroki, T; Lee, HC; Lee, JY; Lee, SH; Lee, YS; Park, IC; Park, MJ; Rhee, CH; Shim, BS; Woo, SH | 1 |
| Coulonval, K; Dumont, JE; Lamy, F; Perpete, S; Vandeput, F | 1 |
| Farnell, MB; He, H; Kogut, MH | 1 |
| Chen, SL; Chen, SM; Li, H; Luo, R; Pang, ZJ; Xing, FQ; Zhang, XQ; Zhao, XS | 1 |
| Chain, BM; Cho, JY; Katz, DR | 1 |
| Galiñanes, M; Hassouna, A; Loubani, M | 1 |
| Chang, KC; Kang, YJ; Kim, HJ; Ko, YS; Lee, YS; Park, MK; Pyo, HS; Seo, HG; Yun-Choi, HS | 1 |
| Basta-Kaim, A; Budziszewska, B; Jaworska-Feil, L; Kubera, M; Lasoń, W; Leśkiewicz, M; Tetich, M | 1 |
| Andreka, P; Bishopric, NH; Evans, WH; Haywood, GA; Martin, PE; Turner, MS; Webster, KA; You, L | 1 |
| Cohen, G; Hörl, WH | 1 |
| Ahn, NS; Cho, SD; Hwang, JW; Jo, EH; Jung, JW; Jung, JY; Kang, KS; Kim, TY; Lee, BH; Lee, YS; Park, JS; Yang, SR; Yoon, BS | 1 |
| Kuan, YH; Lin, CN; Lin, RH; Tsao, LT; Wang, JP | 1 |
| Bakin, AV; Cowell, JK; Li, X; Ranalli, TA; Sossey-Alaoui, K | 1 |
| Kim, JY; Ro, JY | 1 |
| Ilves, M; Kerkelä, R; Mäkinen, M; Orzechowski, HD; Paul, M; Pikkarainen, S; Ruskoaho, H; Tokola, H; Vuolteenaho, O | 1 |
| Cao, X; Dawson, MI; Han, YH; Kolluri, SK; Lin, B; Lin, F; Reed, JC; Stebbins, J; Zhang, XK | 1 |
| Bouillon, R; Mathieu, C; Overbergh, L; Stoffels, K; Verstuyf, A; Waer, M | 1 |
| Hanai, Y; Harada, A; Hosoi, T; Kozawa, O; Matsushima-Nishiwaki, R; Ohta, T; Takai, S; Tokuda, H | 1 |
| Kaneoka, Y; Kozawa, O; Kumada, T; Matsushima-Nishiwaki, R; Takai, S; Tokuda, H; Toyoda, H; Yamaguchi, A; Yasuda, E | 1 |
| Ahmed, A; Cudmore, MJ; Findley, CM; Kontos, CD | 1 |
| Nomura, M; Nomura, N; Sugiyama, K; Takahira, M | 1 |
| Bocking, AD; Casciani, V; Challis, JR; Di Iorio, R; Marinoni, E; Moscarini, M | 1 |
| Hao, X; Wang, L; Wang, X; Xu, Q; Xue, H; Yan, G; Zhang, K | 1 |
| Ballim, RD; Mowla, S; Prince, S; Teng, H | 1 |
| Choi, MS; Hong, H; Jang, BC; Nam, KY; Park, GY; Park, YK; Ryu, NH; Song, DK; Suh, SI | 1 |
| Qiao-Ling, Z; Rong, T; Xiao-xia, Z; Xiao-Zhao, L; Zhi-Chun, L; Zhi-Qin, L | 1 |
| Hamilton, BJ; Stan, RV; Tse, D | 1 |
67 other study(ies) available for sb 203580 and tetradecanoylphorbol acetate
| Article | Year |
|---|---|
The protein kinase inhibitor SB203580 uncouples PMA-induced differentiation of HL-60 cells from phosphorylation of Hsp27.
Topics: Antigens, Surface; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Cell Differentiation; Cell Division; Enzyme Activation; Enzyme Inhibitors; HL-60 Cells; Humans; Imidazoles; Immunophenotyping; Intracellular Signaling Peptides and Proteins; Macrophage-1 Antigen; Macrophages; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Saccharomyces cerevisiae Proteins; Tetradecanoylphorbol Acetate | 1997 |
PMA-induced activation of the p42/44ERK- and p38RK-MAP kinase cascades in HL-60 cells is PKC dependent but not essential for differentiation to the macrophage-like phenotype.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Imidazoles; Indoles; Intracellular Signaling Peptides and Proteins; Macrophages; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Myelin Basic Protein; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Substrate Specificity; Tetradecanoylphorbol Acetate | 1997 |
Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Squamous Cell; Collagenases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Head and Neck Neoplasms; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 1; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; p38 Mitogen-Activated Protein Kinases; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1998 |
The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways.
Topics: Animals; Arsenites; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cells, Cultured; CHO Cells; Cricetinae; Cytokines; Endothelium, Vascular; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Flavonoids; Hot Temperature; Humans; Hydrogen Peroxide; Imidazoles; Intracellular Signaling Peptides and Proteins; Kidney; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Peptide Initiation Factors; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Recombinant Proteins; Signal Transduction; Sorbitol; Stress, Physiological; Tetradecanoylphorbol Acetate; Transfection | 1998 |
Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart.
Topics: Adrenergic alpha-Agonists; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Heart; Imidazoles; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; Myocardial Ischemia; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Reperfusion; Tetradecanoylphorbol Acetate | 1998 |
Hsp27 phosphorylation is induced in alveolar macrophages exposed to CdO-coated silica particles.
Topics: Animals; Cadmium Compounds; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Electrophoresis, Gel, Two-Dimensional; Flavonoids; Heat-Shock Proteins; Hydrogen Peroxide; Imidazoles; Macrophages, Alveolar; Oxides; Phosphoproteins; Phosphorylation; Pyridines; Quartz; Signal Transduction; Silicon Dioxide; Superoxides; Tetradecanoylphorbol Acetate | 1998 |
Role of p38 MAP kinase in myocardial stress.
Topics: Adenosine; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Imidazoles; Indoles; Ischemic Preconditioning, Myocardial; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Myocardial Ischemia; Myocardium; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Pyridines; Rats; Tetradecanoylphorbol Acetate | 1998 |
Different mitogen-activated protein kinase signaling pathways cooperate to regulate tumor necrosis factor alpha gene expression in T lymphocytes.
Topics: Adaptor Proteins, Signal Transducing; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Gene Expression Regulation; Humans; Imidazoles; Ionomycin; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1999 |
The p38 mitogen-activated protein kinase cascade is not required for the stimulation of insulin secretion from rat islets of Langerhans.
Topics: Animals; Arsenites; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cells, Cultured; Colforsin; Enzyme Inhibitors; Glucose; Homeostasis; Imidazoles; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Mitogen-Activated Protein Kinases; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium Compounds; Sorbitol; Tetradecanoylphorbol Acetate; Vanadates | 1999 |
Activation of the neutrophil NADPH oxidase is inhibited by SB 203580, a specific inhibitor of SAPK2/p38.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Superoxides; Tetradecanoylphorbol Acetate | 1999 |
Inhibition of p38 MAP kinase increases okadaic acid mediated AP-1 expression and DNA binding but has no effect on TRE dependent transcription.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Consensus Sequence; DNA; DNA-Binding Proteins; Enzyme Activation; Imidazoles; JNK Mitogen-Activated Protein Kinases; Keratinocytes; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Protein Kinases; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyridines; Response Elements; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription, Genetic; Transcriptional Activation | 1999 |
Distinct roles for p42/p44 and p38 mitogen-activated protein kinases in the induction of IL-2 by IL-1.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genes, Reporter; Humans; Imidazoles; Interleukin-1; Interleukin-2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Sequence Data; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Rabbits; Signal Transduction; Tetradecanoylphorbol Acetate; Thymoma; Thymus Neoplasms; Transcription Factor AP-1; Transfection; Tumor Cells, Cultured | 1999 |
Mitogen-activated protein (MAP) kinases are involved in interleukin-1 (IL-1)-induced IL-6 synthesis in osteoblasts: modulation not of p38 MAP kinase, but of p42/p44 MAP kinase by IL-1-activated protein kinase C.
Topics: Animals; Animals, Newborn; Bridged-Ring Compounds; Cell Line; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; Interleukin-1; Interleukin-6; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Naphthalenes; Norbornanes; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Pyridines; Tetradecanoylphorbol Acetate; Thiocarbamates; Thiones | 1999 |
'Outside-in' signalling mechanisms underlying CD11b/CD18-mediated NADPH oxidase activation in human adherent blood eosinophils.
Topics: Androstadienes; Carbazoles; CD18 Antigens; Cell Adhesion; Cell Count; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Eosinophils; Humans; Imidazoles; Indoles; Isoenzymes; Macrophage-1 Antigen; Maleimides; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyrazoles; Pyridines; Pyrimidines; Signal Transduction; src-Family Kinases; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin | 1999 |
Prevention of neuronal apoptosis by phorbol ester-induced activation of protein kinase C: blockade of p38 mitogen-activated protein kinase.
Topics: Amyloid beta-Peptides; Animals; Brain-Derived Neurotrophic Factor; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Culture Media, Serum-Free; Cycloheximide; Enzyme Inhibitors; Flavonoids; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Kinetics; Maleimides; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Neurons; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Phorbol Esters; Protein Kinase C; Pyridines; Staurosporine; Tetradecanoylphorbol Acetate | 1999 |
Comparative study of vanadate- and phorbol ester-induced cyclo-oxygenase-2 expression in human endothelial cells.
Topics: Cyclooxygenase 2; Endothelium, Vascular; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Isoenzymes; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Tetradecanoylphorbol Acetate; Tyrphostins; Vanadates | 1999 |
Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle. Involvement Of the mitogen- and stress-activated protein kinase 1.
Topics: 3-O-Methylglucose; Amino Acid Sequence; Animals; Biological Transport; Electric Stimulation; Enzyme Inhibitors; Flavonoids; Glycogen; Imidazoles; In Vitro Techniques; Indoles; Insulin; Male; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Phosphopeptides; Phosphorylation; Pyridines; Rats; Rats, Wistar; Signal Transduction; Tetradecanoylphorbol Acetate | 2000 |
p38 MAP kinase is required for vasopressin-stimulated HSP27 induction in aortic smooth muscle cells.
Topics: Animals; Aorta; Arginine Vasopressin; Cell Line; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Imidazoles; Immunoassay; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Naphthalenes; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Phospholipid Ethers; Phosphorylation; Protein Kinase C; Pyridines; RNA, Messenger; Tetradecanoylphorbol Acetate; Vasopressins | 2000 |
Participation of mitogen-activated protein kinase in thapsigargin- and TPA-induced histamine production in murine macrophage RAW 264.7 cells.
Topics: Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Inhibitors; Flavonoids; Histamine Release; Imidazoles; Macrophages; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Thapsigargin | 2000 |
Transforming growth factor beta 1 stimulates expression of the Epstein-Barr virus BZLF1 immediate-early gene product ZEBRA by an indirect mechanism which requires the MAPK kinase pathway.
Topics: Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Viral; Herpesvirus 4, Human; Humans; Imidazoles; Immediate-Early Proteins; Kinetics; MAP Kinase Signaling System; Nitriles; Promoter Regions, Genetic; Protein Kinase C; Pyridines; RNA, Messenger; Smad2 Protein; Smad3 Protein; Smad4 Protein; Smad7 Protein; Tetradecanoylphorbol Acetate; Trans-Activators; Transforming Growth Factor beta; Tumor Cells, Cultured; Viral Proteins | 2000 |
Endothelin-1 induces vascular endothelial growth factor synthesis in osteoblasts: involvement of p38 mitogen-activated protein kinase.
Topics: Animals; Endothelial Growth Factors; Endothelin-1; Enzyme Inhibitors; Estrenes; Flavonoids; Gene Expression Regulation; Imidazoles; Lymphokines; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Naphthalenes; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phorbol Esters; Protein Kinase C; Pyridines; Pyrrolidinones; Receptor, Endothelin A; Receptors, Endothelin; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Endotoxin causes phosphorylation of MARCKS in pulmonary vascular endothelial cells.
Topics: Animals; Cattle; Cell Membrane; Cells, Cultured; Cytosol; Endothelium, Vascular; Enzyme Inhibitors; Genistein; Gram-Negative Bacterial Infections; Imidazoles; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinases; Myosin Light Chains; Myristoylated Alanine-Rich C Kinase Substrate; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Transport; Protein-Tyrosine Kinases; Proteins; Pulmonary Artery; Pyridines; Respiratory Distress Syndrome; Tetradecanoylphorbol Acetate; Thrombin | 2000 |
AP-1 proteins mediate hyperglycemia-induced activation of the human TGF-beta1 promoter in mesangial cells.
Topics: Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Glomerular Mesangium; Glucose; Humans; Hyperglycemia; Imidazoles; Indoles; Maleimides; Mitogen-Activated Protein Kinases; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Podophyllin; Podophyllotoxin; Promoter Regions, Genetic; Pyridines; RNA, Messenger; Sp1 Transcription Factor; Tetradecanoylphorbol Acetate; Tissue Distribution; Transcription Factor AP-1; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2000 |
Combinations of ERK and p38 MAPK inhibitors ablate tumor necrosis factor-alpha (TNF-alpha ) mRNA induction. Evidence for selective destabilization of TNF-alpha transcripts.
Topics: Cell Differentiation; Cells, Cultured; Flavonoids; Humans; Imidazoles; Intercellular Adhesion Molecule-1; Lipopolysaccharide Receptors; Lipopolysaccharides; Mitogen-Activated Protein Kinases; Monocytes; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-jun; Pyridines; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2001 |
Nitric oxide augments release of chemokines from monocytic U937 cells: modulation by anti-inflammatory pathways.
Topics: Chemokine CCL4; Chemokines; Cyclic AMP; Dexamethasone; Enzyme Inhibitors; Genistein; Humans; Imidazoles; Inflammation; Interleukin-8; Macrophage Inflammatory Proteins; Mitogen-Activated Protein Kinases; Monocytes; Nitric Oxide; Nitric Oxide Donors; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Pyridines; Signal Transduction; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Triazenes; U937 Cells | 2000 |
Role of mitogen-activated protein kinases in pulmonary endothelial cells exposed to cyclic strain.
Topics: Animals; Cattle; Cell Movement; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Pulmonary Artery; Pyridines; Response Elements; Stress, Mechanical; Tetradecanoylphorbol Acetate; Transcription Factor AP-1 | 2000 |
Signalling to translational activation of tumour necrosis factor-alpha expression in human THP-1 cells.
Topics: Anisomycin; Blotting, Northern; Blotting, Western; Butadienes; Calcium; Cell Line; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Ionophores; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Monocytes; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Biosynthesis; Protein Synthesis Inhibitors; Pyridines; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Tumor Necrosis Factor-alpha | 2000 |
High levels of glucose stimulate angiotensinogen gene expression via the P38 mitogen-activated protein kinase pathway in rat kidney proximal tubular cells.
Topics: Angiotensinogen; Animals; Blotting, Western; Deoxyglucose; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Glucose; Imidazoles; Kidney Tubules, Proximal; Mannitol; Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sorbitol; Tetradecanoylphorbol Acetate | 2000 |
The Epstein-Barr virus latent membrane protein 1 induces interleukin-10 in Burkitt's lymphoma cells but not in Hodgkin's cells involving the p38/SAPK2 pathway.
Topics: Binding Sites; Burkitt Lymphoma; CD40 Antigens; Enzyme Inhibitors; fas Receptor; Gene Expression; Hodgkin Disease; Humans; Imidazoles; Immunomagnetic Separation; Intercellular Adhesion Molecule-1; Interleukin-10; Jurkat Cells; Lymphoma; Mitogen-Activated Protein Kinases; Mitogens; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Viral Matrix Proteins | 2001 |
Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade.
Topics: Acetylcysteine; Amanitins; Aminoacetonitrile; Apoptosis; Benzoquinones; Bryostatins; Butadienes; Curcumin; Cysteine Endopeptidases; Dactinomycin; Diterpenes; Drug Synergism; Enzyme Activation; Flavonoids; Humans; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; Lactones; Macrolides; Maleimides; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Nitriles; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Kinase C; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-raf; Pyridines; Quinones; Terpenes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Type C Phospholipases; U937 Cells; Ubiquitins | 2001 |
Thrombin activates p38 mitogen-activated protein kinase in vascular smooth muscle cells.
Topics: Animals; Aorta, Thoracic; Cell Division; Cells, Cultured; DNA; Enzyme Activation; Enzyme Inhibitors; Heterotrimeric GTP-Binding Proteins; Imidazoles; Indoles; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Rats; Tetradecanoylphorbol Acetate; Thrombin | 2001 |
PKCdelta-dependent deubiquitination and stabilization of Gadd45 in A431 cells overexposed to EGF.
Topics: Acetophenones; Benzopyrans; Cell Division; Cycloheximide; DNA Damage; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; GADD45 Proteins; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Isoenzymes; Kinetics; Leupeptins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Proteins; Pyridines; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Ubiquitins | 2001 |
Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27.
Topics: Anisomycin; Arsenites; Butadienes; Cadmium Chloride; Carcinogens; Dithiothreitol; Enzyme Inhibitors; Flavonoids; Glioma; Heat-Shock Proteins; Humans; Hydrogen Peroxide; Imidazoles; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Osmotic Pressure; Oxidants; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Synthesis Inhibitors; Pyridines; Sodium Compounds; Sorbitol; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2001 |
Hypertonic saline activation of p38 MAPK primes the PMN respiratory burst.
Topics: Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxygen; p38 Mitogen-Activated Protein Kinases; Pyridines; Respiratory Burst; Saline Solution, Hypertonic; Superoxides; Tetradecanoylphorbol Acetate | 2001 |
Roles of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase in apoptosis of human monoblastic leukemia U937 cells by lectin-II isolated from Korean mistletoe.
Topics: Apoptosis; DNA Fragmentation; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Leukemia, Monocytic, Acute; Mistletoe; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Plant Preparations; Plant Proteins; Pyridines; Ribosome Inactivating Proteins, Type 2; Signal Transduction; Tetradecanoylphorbol Acetate; Toxins, Biological; U937 Cells | 2001 |
Macrophage stimulating protein (MSP) evokes superoxide anion production by human macrophages of different origin.
Topics: Adult; Androstadienes; Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Flavonoids; Growth Substances; Hepatocyte Growth Factor; Humans; Imidazoles; Insecta; Macrophages; Middle Aged; Monocytes; N-Formylmethionine Leucyl-Phenylalanine; Protein Kinase C; Proto-Oncogene Proteins; Pyridines; Receptors, Drug; Respiratory Burst; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin | 2001 |
Phorbol esters inhibit fibroblast growth factor-2-stimulated fibroblast proliferation by a p38 MAP kinase dependent pathway.
Topics: 3T3 Cells; Animals; Cell Division; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblast Growth Factor 2; Fibroblasts; Flavonoids; Imidazoles; Indoles; Isoenzymes; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Pyridines; Tetradecanoylphorbol Acetate; Time Factors | 2002 |
The p38 mitogen-activated protein kinase is involved in stress-induced phospholipase D activation in vascular smooth muscle cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Mannitol; MAP Kinase Kinase 6; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phospholipase D; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Time Factors; Vanadates | 2002 |
Modulation of phorbol ester-induced regulation of matrix metalloproteinases and tissue inhibitors of metalloproteinases by SB203580, a specific inhibitor of p38 mitogen-activated protein kinase.
Topics: Biocompatible Materials; Carcinogens; Collagen; Drug Combinations; Enzyme Activation; Enzyme Inhibitors; Glioblastoma; Humans; Imidazoles; Laminin; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinases; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Proteoglycans; Pyridines; Tetradecanoylphorbol Acetate; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Tumor Cells, Cultured | 2002 |
Involvement of both extracellular signal-regulated kinase and c-jun N-terminal kinase pathways in the 12-O-tetradecanoylphorbol-13-acetate-induced upregulation of p21(Cip1) in colon cancer cells.
Topics: Adenocarcinoma; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Chromosome Mapping; Colonic Neoplasms; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Disease Progression; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Transport; Pyridines; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Up-Regulation | 2002 |
Protein kinase C-alpha activation by phorbol ester induces secretion of gelatinase B/MMP-9 through ERK 1/2 pathway in capillary endothelial cells.
Topics: Animals; Capillaries; Cattle; Endothelium, Vascular; Enzyme Activation; Flavonoids; Imidazoles; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Kinase C-alpha; Pyridines; Tetradecanoylphorbol Acetate | 2003 |
Role of the different mitogen-activated protein kinase subfamilies in the stimulation of dog and human thyroid epithelial cell proliferation by cyclic adenosine 5'-monophosphate and growth factors.
Topics: Animals; Arsenites; Carcinogens; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Dogs; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Flavonoids; Hepatocyte Growth Factor; Humans; Hypoglycemic Agents; Imidazoles; Insulin; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Sodium Compounds; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin | 2003 |
Inflammatory agonist stimulation and signal pathway of oxidative burst in neonatal chicken heterophils.
Topics: Animals; Animals, Newborn; Chickens; Enzyme Inhibitors; Flavonoids; Fluoresceins; Imidazoles; Inflammation; Lipopolysaccharides; Male; Mitogen-Activated Protein Kinases; Neutrophils; Protein Kinase C; Pyridines; Respiratory Burst; Salmonella enteritidis; Signal Transduction; Staphylococcus aureus; Teichoic Acids; Tetradecanoylphorbol Acetate | 2003 |
[Role of p38 pathway in PMA-induced in vitro invasion of JAR human choriocarcinoma cell line].
Topics: Cell Division; Choriocarcinoma; Female; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; p38 Mitogen-Activated Protein Kinases; Pregnancy; Pyridines; Tetradecanoylphorbol Acetate; Uterine Neoplasms | 2003 |
Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation.
Topics: Acetophenones; Adenosine Triphosphate; Benzopyrans; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; CD18 Antigens; Cell Aggregation; Cycloheximide; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; Indoles; Integrin beta1; Isoenzymes; Maleimides; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Phosphotransferases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Staurosporine; Temperature; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; U937 Cells | 2003 |
Delayed preconditioning of the human myocardium: signal transduction and clinical implications.
Topics: Acetylcholine; Aged; Alkaloids; Anisomycin; Antihypertensive Agents; Benzophenanthridines; Culture Techniques; Decanoic Acids; Diazoxide; Enzyme Activation; Enzyme Inhibitors; Female; Heart Atria; Humans; Hydroxy Acids; Imidazoles; Ischemic Preconditioning, Myocardial; Male; Middle Aged; Mitogen-Activated Protein Kinases; Myocardial Ischemia; Myocardium; p38 Mitogen-Activated Protein Kinases; Phenanthridines; Phenylephrine; Potassium Channel Blockers; Potassium Channels; Protein Kinase C; Pyridines; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors | 2004 |
Induction of manganese-superoxide dismutase by YS 51, a synthetic 1-(beta-naphtylmethyl)6,7-dihydroxy- 1,2,3,4-tetrahydroisoquinoline alkaloid: implication for anti-inflammatory actions.
Topics: Animals; Blotting, Northern; Curcumin; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Endothelial Cells; Endothelium, Vascular; Enzyme Induction; Flavonoids; Gene Expression Regulation, Enzymologic; HeLa Cells; Humans; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Maleimides; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phorbol Esters; Phosphorylation; Pulmonary Artery; Pyridines; RNA, Messenger; Sheep; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Tetrahydroisoquinolines; Tumor Necrosis Factor-alpha | 2004 |
Mood stabilizers inhibit glucocorticoid receptor function in LMCAT cells.
Topics: Amphetamine; Animals; Anthracenes; Antimanic Agents; Blotting, Western; Carbamazepine; Cell Line; Cell Survival; Chloramphenicol O-Acetyltransferase; Corticosterone; Dose-Response Relationship, Drug; Flavonoids; Gene Expression Regulation, Enzymologic; Imidazoles; Indoles; Inositol; Lithium; Maleimides; Protein Kinase C; Protein Kinase C-alpha; Pyridines; Receptors, Glucocorticoid; Tamoxifen; Tetradecanoylphorbol Acetate; Valproic Acid | 2004 |
Reversible connexin 43 dephosphorylation during hypoxia and reoxygenation is linked to cellular ATP levels.
Topics: Adenosine Triphosphate; Alkaloids; Aminoimidazole Carboxamide; Animals; Antimycin A; Benzophenanthridines; Brefeldin A; Carbazoles; Cell Hypoxia; Cells, Cultured; Connexin 43; Cycloheximide; Deoxyglucose; Flavonoids; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Maleimides; Myocardial Contraction; Myocytes, Cardiac; Okadaic Acid; Ouabain; Phenanthridines; Phosphorylation; Potassium Cyanide; Protein Processing, Post-Translational; Pyridines; Pyrroles; Rats; Recombinant Fusion Proteins; Ribonucleotides; Staurosporine; Tacrolimus; Tetradecanoylphorbol Acetate | 2004 |
Retinol binding protein isolated from acute renal failure patients inhibits polymorphonuclear leucocyte functions.
Topics: Acute Kidney Injury; Apoptosis; Chemotaxis, Leukocyte; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Humans; Imidazoles; Male; Neutrophils; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phagocytosis; Pyridines; Retinol-Binding Proteins; Tetradecanoylphorbol Acetate | 2004 |
Role of gap junctional intercellular communication (GJIC) through p38 and ERK1/2 pathway in the differentiation of rat neuronal stem cells.
Topics: Animals; Blotting, Western; Cell Communication; Cell Differentiation; Connexin 43; Connexins; Flavonoids; Gap Junction beta-1 Protein; Gap Junctions; Imidazoles; Neurons; Pyridines; Rats; Stem Cells; Tetradecanoylphorbol Acetate | 2005 |
Artocarpol A stimulation of superoxide anion generation in neutrophils involved the activation of PLC, PKC and p38 mitogen-activated PK signaling pathways.
Topics: Animals; Butadienes; Calcium; Cell-Free System; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Heterocyclic Compounds, 4 or More Rings; Imidazoles; Immunoblotting; Indoles; Maleimides; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Pyridines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Signal Transduction; Superoxides; Tetradecanoylphorbol Acetate; Type C Phospholipases | 2005 |
WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expression.
Topics: Actins; Adenocarcinoma; Cell Line, Tumor; Cell Movement; Down-Regulation; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Imidazoles; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Microfilament Proteins; Neoplasm Invasiveness; Neuroblastoma; p38 Mitogen-Activated Protein Kinases; Pyridines; RNA, Messenger; RNA, Small Interfering; Tetradecanoylphorbol Acetate; Time Factors; Wiskott-Aldrich Syndrome Protein Family | 2005 |
Signal pathway of cytokines produced by reactive oxygen species generated from phorbol myristate acetate-stimulated HMC-1 cells.
Topics: Antioxidants; Free Radical Scavengers; Humans; Imidazoles; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Mast Cells; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Thiourea; Transcription Factors; Tumor Necrosis Factor-alpha | 2005 |
Inverse regulation of preproendothelin-1 and endothelin-converting enzyme-1beta genes in cardiac cells by mechanical load.
Topics: Animals; Aspartic Acid Endopeptidases; Cell Line; Cells, Cultured; Endothelial Cells; Endothelin-1; Endothelin-Converting Enzymes; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; MAP Kinase Kinase 1; Metalloendopeptidases; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Receptor, Endothelin A; Stress, Mechanical; Tetradecanoylphorbol Acetate; Transfection | 2006 |
Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt.
Topics: Adamantane; Anisomycin; Apoptosis; Cell Line, Tumor; Cell Nucleus; Cinnamates; DNA-Binding Proteins; Enzyme Activation; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 7; MAP Kinase Kinase Kinase 1; Mutagenesis, Site-Directed; Nuclear Receptor Subfamily 4, Group A, Member 1; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Transport; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyridines; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Recombinant Fusion Proteins; Tetradecanoylphorbol Acetate; Transcription Factors | 2006 |
Immune regulation of 25-hydroxyvitamin D-1alpha-hydroxylase in human monocytic THP1 cells: mechanisms of interferon-gamma-mediated induction.
Topics: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Anthracenes; Blotting, Western; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Cell Line; Enzyme Induction; Flavonoids; Humans; Imidazoles; Interferon-gamma; Mitogen-Activated Protein Kinases; Monocytes; Protein Kinase Inhibitors; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction; STAT1 Transcription Factor; Tetradecanoylphorbol Acetate | 2006 |
(-)-Epigallocatechin gallate suppresses endothelin-1-induced interleukin-6 synthesis in osteoblasts: inhibition of p44/p42 MAP kinase activation.
Topics: Animals; Anthracenes; Catechin; Cells, Cultured; Endothelin-1; Enzyme Activation; Flavonoids; Imidazoles; Interleukin-6; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-raf; Pyridines; Tetradecanoylphorbol Acetate | 2007 |
Protein kinase C delta regulates the phosphorylation of heat shock protein 27 in human hepatocellular carcinoma.
Topics: Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Heat-Shock Proteins; Humans; Imidazoles; Liver Neoplasms; Mitogen-Activated Protein Kinase 1; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C-delta; Pyridines; RNA, Small Interfering; Tetradecanoylphorbol Acetate | 2007 |
VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling.
Topics: Angiopoietin-1; Angiopoietin-2; Animals; Apoptosis; Cells, Cultured; Chromones; Dipeptides; Endothelial Cells; Fibroblasts; Humans; Imidazoles; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Morpholines; Neovascularization, Physiologic; NIH 3T3 Cells; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Peptide Hydrolases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Pyridines; Receptor, TIE-2; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Vascular Endothelial Growth Factor A | 2007 |
Phorbol 12-myristate 13-acetate-activated protein kinase C increased migratory activity of subconjunctival fibroblasts via stress-activated protein kinase pathways.
Topics: Actins; Animals; Anthracenes; Cell Movement; Cells, Cultured; Conjunctiva; Enzyme Activation; Fibroblasts; Imidazoles; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Pseudopodia; Pyridines; Rats; Rats, Wistar; Signal Transduction; Tetradecanoylphorbol Acetate | 2007 |
Opposite effect of phorbol ester PMA on PTGS2 and PGDH mRNA expression in human chorion trophoblast cells.
Topics: Calcium; Carcinogens; Cells, Cultured; Chorion; Cyclooxygenase 2; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Humans; Hydroxyprostaglandin Dehydrogenases; Imidazoles; Indoles; Maleimides; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Kinase 4; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Pregnancy; Protein Kinase C; Pyridines; RNA, Messenger; Tetradecanoylphorbol Acetate; Trophoblasts | 2008 |
p38 kinase/cytosolic phospholipase A2/cyclooxygenase-2 pathway: a new signaling cascade for lipopolysaccharide-induced interleukin-1beta and interleukin-6 release in differentiated U937 cells.
Topics: Blotting, Western; Cell Differentiation; Cyclooxygenase 2; Enzyme Inhibitors; Humans; Imidazoles; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; p38 Mitogen-Activated Protein Kinases; Phospholipases A2, Cytosolic; Phosphorylation; Pyridines; Signal Transduction; Tetradecanoylphorbol Acetate; U937 Cells | 2008 |
Phosphorylation of histone H3 by protein kinase C signaling plays a critical role in the regulation of the developmentally important TBX2 gene.
Topics: Binding Sites; Blotting, Western; Cell Line; Chromatin Immunoprecipitation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Gene Expression; Histones; Humans; Imidazoles; Indoles; Maleimides; Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Kinase C; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases, 90-kDa; RNA Interference; Serine; Signal Transduction; Sp1 Transcription Factor; T-Box Domain Proteins; Tetradecanoylphorbol Acetate | 2009 |
Differential down-regulation of COX-2 and MMP-13 in human skin fibroblasts by glucosamine-hydrochloride.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Carcinogens; Cell Line; Cyclooxygenase 2; Down-Regulation; Enzyme Inhibitors; Fibroblasts; Glucosamine; Humans; Imidazoles; Interleukin-1beta; Keratinocytes; Matrix Metalloproteinase 13; Matrix Metalloproteinase Inhibitors; Protein Kinases; Pyridines; Skin; Tetradecanoylphorbol Acetate | 2009 |
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) mediates p38 mitogen-activated protein kinase activation and signal transduction in peripheral blood mononuclear cells from patients with lupus nephritis.
Topics: Adolescent; Adult; Antibodies, Monoclonal; Cells, Cultured; Chemokine CCL2; Female; Humans; Imidazoles; Interleukin-10; Leukocytes, Mononuclear; Lupus Erythematosus, Systemic; Lupus Nephritis; Male; MAP Kinase Signaling System; Middle Aged; p38 Mitogen-Activated Protein Kinases; Phytohemagglutinins; Pyridines; Receptors, Tumor Necrosis Factor; Tetradecanoylphorbol Acetate; Tumor Necrosis Factors; TWEAK Receptor; Young Adult | 2012 |
Phorbol esters induce PLVAP expression via VEGF and additional secreted molecules in MEK1-dependent and p38, JNK and PI3K/Akt-independent manner.
Topics: Anthracenes; Autocrine Communication; Axitinib; Butadienes; Flavonoids; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Indazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 4; Membrane Proteins; Nitriles; Phosphatidylinositol 3-Kinases; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; RNA, Small Interfering; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2019 |