Compounds > sb 203580
Page last updated: 2024-09-05

sb 203580 and tamoxifen

sb 203580 has been researched along with tamoxifen in 11 studies

Compound Research Comparison

Studies
(sb 203580)		Trials
(sb 203580)		Recent Studies (post-2010)
(sb 203580)		Studies
(tamoxifen)		Trials
(tamoxifen)		Recent Studies (post-2010) (tamoxifen)
3,48941,13720,6302,2276,256

Protein Interaction Comparison

ProteinTaxonomysb 203580 (IC50)tamoxifen (IC50)
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.46
Serine/threonine-protein kinase D3Homo sapiens (human)1
Bile salt export pumpHomo sapiens (human)10
Epidermal growth factor receptorHomo sapiens (human)3.553
Estrogen receptorHomo sapiens (human)0.9266
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)2.949
Protein kinase C gamma typeHomo sapiens (human)1
Protein kinase C beta typeHomo sapiens (human)1
Tyrosine-protein kinase LckHomo sapiens (human)8.033
Tyrosine-protein kinase FynHomo sapiens (human)1.195
Progesterone receptorHomo sapiens (human)0.1288
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.472
Muscarinic acetylcholine receptor M2Homo sapiens (human)7.793
Muscarinic acetylcholine receptor M4Homo sapiens (human)4.817
ATP-dependent translocase ABCB1Homo sapiens (human)6.4
Muscarinic acetylcholine receptor M5Homo sapiens (human)2.585
Alpha-2A adrenergic receptorHomo sapiens (human)1.935
Adenosine receptor A3Homo sapiens (human)3.701
Muscarinic acetylcholine receptor M1Homo sapiens (human)2.829
Steroid hormone receptor ERR1Homo sapiens (human)0.2
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)0.967
Beta-3 adrenergic receptorHomo sapiens (human)7.703
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)3.701
Protein kinase C alpha typeHomo sapiens (human)1
Alpha-2B adrenergic receptorHomo sapiens (human)3.518
Muscarinic acetylcholine receptor M3Homo sapiens (human)2.974
Substance-K receptorHomo sapiens (human)3.67
D(1A) dopamine receptorHomo sapiens (human)8.502
Prostaglandin G/H synthase 1Homo sapiens (human)4.391
Sodium-dependent noradrenaline transporter Homo sapiens (human)1.472
Thromboxane-A synthase Homo sapiens (human)0.916
Protein kinase C eta typeHomo sapiens (human)1
Histamine H2 receptorHomo sapiens (human)9.396
Alpha-1D adrenergic receptorHomo sapiens (human)4.982
5-hydroxytryptamine receptor 2AHomo sapiens (human)4.801
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.46
Adenosine receptor A2aHomo sapiens (human)7.099
Sodium-dependent serotonin transporterHomo sapiens (human)2.334
D(3) dopamine receptorHomo sapiens (human)1.072
5-hydroxytryptamine receptor 2BHomo sapiens (human)2.084
Protein kinase C iota typeHomo sapiens (human)1
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)3.701
5-hydroxytryptamine receptor 6Homo sapiens (human)2.679
Estrogen-related receptor gammaHomo sapiens (human)0.0622
Sodium-dependent dopamine transporter Homo sapiens (human)1.841
Protein kinase C epsilon typeHomo sapiens (human)1
Protein kinase C theta typeHomo sapiens (human)1
Protein kinase C zeta typeHomo sapiens (human)1
Protein kinase C delta typeHomo sapiens (human)1
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.2759
Platelet-activating factor acetylhydrolaseHomo sapiens (human)0.904
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomeraseHomo sapiens (human)0.012
Serine/threonine-protein kinase D1Homo sapiens (human)1
Nuclear receptor subfamily 3 group C member 3 Bos taurus (cattle)0.967
Estrogen receptor betaHomo sapiens (human)0.7809
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.021
7-dehydrocholesterol reductaseHomo sapiens (human)0.012

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's11 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H1
Shapiro, DJ; Zhang, CC1
Bai, W; Jiang, F; Lee, H; Nicosia, SV; Su, B; Wang, Q; Yang, J1
Balmanno, K; Cook, SJ; Garner, AP; Todd, DE; Weston, CR1
Gutiérrez-Sagal, R; Herrera-Muñoz, J; Pasapera Limón, AM; Ulloa-Aguirre, A1
Arimoto-Ishida, E; Hisamoto, K; Ikebuchi, Y; Kimura, A; Mabuchi, S; Murata, Y; Nishio, Y; Ohmichi, M; Takahashi, K; Tasaka, K1
Cho, S; Kim, B; Kim, J; Kwon, S; Lee, S; Park, S; Won, KJ1
Basta-Kaim, A; Budziszewska, B; Jaworska-Feil, L; Kubera, M; Lasoń, W; Leśkiewicz, M; Tetich, M1
Hoffmann, EK; Marshall, WS; Ossum, CG1
Cheng, J; Shapiro, DJ; Yu, DV; Zhou, JH1
Hatae, J; Honda, A; Inoue, R; Lin, H; Takami, N1

Other Studies

11 other study(ies) available for sb 203580 and tamoxifen

ArticleYear
Identifying off-target effects and hidden phenotypes of drugs in human cells.
    Nature chemical biology, 2006, Volume: 2, Issue:6

    Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

2006
Activation of the p38 mitogen-activated protein kinase pathway by estrogen or by 4-hydroxytamoxifen is coupled to estrogen receptor-induced apoptosis.
    The Journal of biological chemistry, 2000, Jan-07, Volume: 275, Issue:1

    Topics: Apoptosis; Breast Neoplasms; Cell Transformation, Neoplastic; Enzyme Induction; Estradiol; Female; HeLa Cells; Humans; Imidazoles; MAP Kinase Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Pyridines; Receptors, Estrogen; Recombinant Proteins; Tamoxifen

2000
MEKK1 activation of human estrogen receptor alpha and stimulation of the agonistic activity of 4-hydroxytamoxifen in endometrial and ovarian cancer cells.
    Molecular endocrinology (Baltimore, Md.), 2000, Volume: 14, Issue:11

    Topics: Endometrial Neoplasms; Enzyme Activation; Enzyme Inhibitors; Estrogen Antagonists; Estrogen Receptor alpha; Female; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinase 2; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Pyridines; Receptors, Estrogen; Tamoxifen; Transcription, Genetic; Tumor Cells, Cultured

2000
Delta MEKK3:ER* activation induces a p38 alpha/beta 2-dependent cell cycle arrest at the G2 checkpoint.
    Oncogene, 2002, Nov-21, Volume: 21, Issue:53

    Topics: Animals; Aphidicolin; Apoptosis; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cells, Cultured; Cricetinae; Cyclin A; Cyclin B; Cyclin B1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; DNA Methylation; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; G1 Phase; G2 Phase; Gene Silencing; Genes, Synthetic; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 3; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase 11; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Rats; Receptors, Estrogen; Recombinant Fusion Proteins; Sequence Deletion; Tamoxifen

2002
The phosphatidylinositol 3-kinase inhibitor LY294002 binds the estrogen receptor and inhibits 17beta-estradiol-induced transcriptional activity of an estrogen sensitive reporter gene.
    Molecular and cellular endocrinology, 2003, Feb-28, Volume: 200, Issue:1-2

    Topics: Animals; Binding Sites; Binding, Competitive; Cells, Cultured; Chromones; Enzyme Inhibitors; Estradiol; Female; Gene Expression Regulation; Genes, Reporter; Genetic Vectors; HeLa Cells; Humans; Imidazoles; Isoquinolines; L Cells; Mice; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Plasmids; Pyridines; Receptors, Estrogen; Sulfonamides; Tamoxifen; Transcription, Genetic

2003
Tamoxifen inhibits cell proliferation via mitogen-activated protein kinase cascades in human ovarian cancer cell lines in a manner not dependent on the expression of estrogen receptor or the sensitivity to cisplatin.
    Endocrinology, 2004, Volume: 145, Issue:3

    Topics: Adenocarcinoma, Papillary; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antioxidants; Apoptosis; Cell Division; Cell Line, Tumor; Cell Survival; Cisplatin; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Flavonoids; G1 Phase; Gene Expression; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Ovarian Neoplasms; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Estrogen; Tamoxifen

2004
Tamoxifen induces vasorelaxation via inhibition of mitogen-activated protein kinase in rat aortic smooth muscle.
    The Journal of veterinary medical science, 2003, Volume: 65, Issue:11

    Topics: Animals; Aorta; Blotting, Western; Endothelin-1; Estradiol; Fulvestrant; Imidazoles; MAP Kinase Signaling System; Muscle, Smooth, Vascular; Pyridines; Rats; Tamoxifen; Vasodilation

2003
Mood stabilizers inhibit glucocorticoid receptor function in LMCAT cells.
    European journal of pharmacology, 2004, Jul-14, Volume: 495, Issue:2-3

    Topics: Amphetamine; Animals; Anthracenes; Antimanic Agents; Blotting, Western; Carbamazepine; Cell Line; Cell Survival; Chloramphenicol O-Acetyltransferase; Corticosterone; Dose-Response Relationship, Drug; Flavonoids; Gene Expression Regulation, Enzymologic; Imidazoles; Indoles; Inositol; Lithium; Maleimides; Protein Kinase C; Protein Kinase C-alpha; Pyridines; Receptors, Glucocorticoid; Tamoxifen; Tetradecanoylphorbol Acetate; Valproic Acid

2004
Hypotonic shock mediation by p38 MAPK, JNK, PKC, FAK, OSR1 and SPAK in osmosensing chloride secreting cells of killifish opercular epithelium.
    The Journal of experimental biology, 2005, Volume: 208, Issue:Pt 6

    Topics: Alkaloids; Animals; Benzophenanthridines; Blotting, Western; Chlorides; Cyclic AMP-Dependent Protein Kinases; Electrophoresis, Polyacrylamide Gel; Electrophysiology; Epithelium; Focal Adhesion Protein-Tyrosine Kinases; Fundulidae; Imidazoles; Immunohistochemistry; Ion Channels; Isoquinolines; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Nova Scotia; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Phenanthridines; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Saline Solution, Hypertonic; Sulfonamides; Tamoxifen; Water-Electrolyte Balance

2005
Delayed and persistent ERK1/2 activation is required for 4-hydroxytamoxifen-induced cell death.
    Steroids, 2007, Volume: 72, Issue:11-12

    Topics: Caspase 3; Caspase 9; Cell Death; Enzyme Activation; Epidermal Growth Factor; Estradiol; Estrogen Antagonists; Flavonoids; Fulvestrant; HeLa Cells; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Estrogen; Tamoxifen; Time Factors

2007
17beta-Estradiol-induced enhancement of estrogen receptor biosynthesis via MAPK pathway in mouse skeletal muscle myoblasts.
    The journal of physiological sciences : JPS, 2009, Volume: 59, Issue:3

    Topics: Animals; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrogens; Flavonoids; Fulvestrant; Imidazoles; Mice; Mitogen-Activated Protein Kinase Kinases; Models, Animal; Muscle, Skeletal; Myoblasts, Skeletal; Pyridines; Receptors, Estrogen; Signal Transduction; Tamoxifen

2009