Compounds > sb 203580
Page last updated: 2024-09-05

sb 203580 and tak-715

sb 203580 has been researched along with tak-715 in 4 studies

Compound Research Comparison

Studies
(sb 203580)		Trials
(sb 203580)		Recent Studies (post-2010)
(sb 203580)		Studies
(tak-715)		Trials
(tak-715)		Recent Studies (post-2010) (tak-715)
3,48941,13716013

Protein Interaction Comparison

ProteinTaxonomysb 203580 (IC50)tak-715 (IC50)
Mitogen-activated protein kinase 13Homo sapiens (human)0.24
Mitogen-activated protein kinase 12Homo sapiens (human)0.24
Mitogen-activated protein kinase 11Homo sapiens (human)0.22
Mitogen-activated protein kinase 14Homo sapiens (human)0.1235

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hajduk, PJ; Johnson, EF; Kifle, L; Merta, PJ; Metz, JT; Soni, NB1
Albrecht, W; Bauer, SM; Laufer, SA; Unger, A1
Azevedo, R; de Vlieg, J; Kazemier, B; Oubrie, A; Raaijmakers, H; van Zeeland, M1
Falck, D; Giera, M; Honing, M; Kool, J; Niessen, WM; Rahimi Pirkolachachi, F1

Other Studies

4 other study(ies) available for sb 203580 and tak-715

ArticleYear
Navigating the kinome.
    Nature chemical biology, 2011, Volume: 7, Issue:4

    Topics: Drug Design; Pharmacogenetics; Protein Kinases; Proteome; Systems Biology

2011
Discovery of N-{4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-acetamide (CBS-3595), a Dual p38α MAPK/PDE-4 Inhibitor with Activity against TNFα-Related Diseases.
    Journal of medicinal chemistry, 2017, 07-13, Volume: 60, Issue:13

    Topics: Aminopyridines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Discovery; Humans; Imidazoles; Inflammation; Mitogen-Activated Protein Kinase 14; Phosphodiesterase 4 Inhibitors; Protein Kinase Inhibitors; Tumor Necrosis Factor-alpha

2017
X-ray structure of p38α bound to TAK-715: comparison with three classic inhibitors.
    Acta crystallographica. Section D, Biological crystallography, 2012, Volume: 68, Issue:Pt 8

    Topics: Adenosine Triphosphate; Benzamides; Catalytic Domain; Cloning, Molecular; Crystallization; Crystallography, X-Ray; Humans; Imidazoles; Indoles; Ligands; p38 Mitogen-Activated Protein Kinases; Protein Binding; Protein Conformation; Protein Kinase Inhibitors; Pyridazines; Pyridines; Pyrimidines; Structure-Activity Relationship; Thiazoles

2012
Comparison of (bio-)transformation methods for the generation of metabolite-like compound libraries of p38α MAP kinase inhibitors using high-resolution screening.
    Journal of pharmaceutical and biomedical analysis, 2014, Volume: 88

    Topics: Bacillus megaterium; Benzamides; Chemistry, Pharmaceutical; Cytochrome P-450 Enzyme System; High-Throughput Screening Assays; Humans; Hydrogen Peroxide; Imidazoles; Indoles; Light; Liver; Microsomes, Liver; Mitogen-Activated Protein Kinase 14; Naphthalenes; Oxygen; Photochemistry; Piperazines; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Recombinant Proteins; Structure-Activity Relationship; Thiazoles

2014