sb 203580 has been researched along with sphingosine in 23 studies
| Studies (sb 203580) | Trials (sb 203580) | Recent Studies (post-2010) (sb 203580) | Studies (sphingosine) | Trials (sphingosine) | Recent Studies (post-2010) (sphingosine) |
|---|---|---|---|---|---|
| 3,489 | 4 | 1,137 | 8,325 | 117 | 3,459 |
| Protein | Taxonomy | sb 203580 (IC50) | sphingosine (IC50) |
|---|---|---|---|
| ubiquitin-conjugating enzyme E2 N | Homo sapiens (human) | 6.3125 | |
| cAMP-dependent protein kinase catalytic subunit alpha | Rattus norvegicus (Norway rat) | 0.098 | |
| Sphingosine kinase 2 | Homo sapiens (human) | 1.56 | |
| Sphingosine kinase 1 | Homo sapiens (human) | 3.86 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (8.70) | 18.2507 |
| 2000's | 16 (69.57) | 29.6817 |
| 2010's | 5 (21.74) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Duronio, V; Foltz, IN; Scheid, MP; Schrader, JW; Young, PR | 1 |
| Ito, H; Kato, K; Kozawa, O; Matsuno, H; Niwa, M; Tanabe, K; Uematsu, T | 1 |
| Kawamura, H; Kozawa, O; Uematsu, T | 1 |
| Kawamura, H; Kozawa, O; Matsuno, H; Uematsu, T | 1 |
| Akamatsu, S; Dohi, S; Kozawa, O; Tanabe, K; Uematsu, T; Yamamoto, T | 1 |
| Chang, YJ; Chen, CC; Chen, JJ; Sun, YT | 1 |
| Choi, MR; Suh, HW; Won, JS | 1 |
| Brugg, B; Caboche, J; Lemaigre-Dubreuil, Y; Mariani, J; Vanhoutte, P; Willaime, S | 1 |
| Bralet, MP; D'ortho, MP; Laperche, Y; Mavier, P; Preaux, AM | 1 |
| Brami-Cherrier, K; Brugg, B; Caboche, J; Mariani, J; Willaime-Morawek, S | 1 |
| Alvarado-Kristensson, M; Andersson, T; Chihab, R; Pörn-Ares, MI | 1 |
| Joo, YH; Kim, DS; Kim, SY; Kwon, SB; Lee, JE; Park, KC; Youn, SW | 1 |
| Akiyama, N; Hirabayashi, T; Murayama, T; Shimamura, K; Takashiro, Y | 1 |
| Harada, A; Ishisaki, A; Kanno, Y; Kozawa, O; Takenaka, M; Tokuda, H | 1 |
| Endoh, D; Hamasu, T; Hayashi, M; Kawana, A; Matsumoto, M; Okui, T | 1 |
| Koide, Y; Murayama, T; Nakamura, H; Nishida, A; Takashiro, Y | 1 |
| Brown, DL; Kohama, K; Kumagai, H; Li, S; Nakamura, A; Tanaka, H; Thatcher, SE; Wang, HH; Wright, GL; Yoshiyama, S | 1 |
| Bae, YS; Kim, JM; Kim, MK; Kim, SD; Lee, HY; Lee, SY; Park, KS; Ryu, SH | 1 |
| Chen, YE; Han, JY; Huang, Y; Ji, L; Liu, D; Pan, B; Pennathur, S; Tong, X; Zhang, Y; Zheng, L | 1 |
| Adyshev, DM; Dudek, SM; Elangovan, VR; Garcia, JG; Moldobaeva, NK | 1 |
| Huang, H; Huang, J; Huang, K; Lan, T; Liu, P; Liu, W; Peng, J; Shen, X; Xie, X | 1 |
| Furukawa, Y; Ishii, T; Karakida, S; Kawano, Y; Kira, N; Narahara, H | 1 |
| Beppu, M; Kato, T; Masuko, K; Murata, M; Nakamura, H; Yudoh, K | 1 |
23 other study(ies) available for sb 203580 and sphingosine
| Article | Year |
|---|---|
Ceramide and cyclic adenosine monophosphate (cAMP) induce cAMP response element binding protein phosphorylation via distinct signaling pathways while having opposite effects on myeloid cell survival.
Topics: Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Survival; Ceramides; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Hematopoietic Stem Cells; Humans; Imidazoles; Interleukin-3; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Signal Transduction; Sphingosine; Tumor Necrosis Factor-alpha; U937 Cells | 1999 |
Sphingosine 1-phosphate regulates heat shock protein 27 induction by a p38 MAP kinase-dependent mechanism in aortic smooth muscle cells.
Topics: Animals; Aorta; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Flavonoids; Gene Expression Regulation; Heat-Shock Proteins; Imidazoles; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Pyridines; Rats; RNA, Messenger; Signal Transduction; Sphingosine; Virulence Factors, Bordetella | 1999 |
Sphingosine 1-phosphate amplifies phosphoinositide hydrolysis stimulated by prostaglandin f2 alpha in osteoblasts: involvement of p38MAP kinase.
Topics: Analysis of Variance; Animals; Blotting, Western; Cells, Cultured; Dinoprost; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Hydrolysis; Imidazoles; Lysophospholipids; Mice; Mitogen-Activated Protein Kinases; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositols; Pyridines; Sphingosine; Tumor Necrosis Factor-alpha; Type C Phospholipases | 2000 |
p38 MAP kinase is involved in the signalling of sphingosine in osteoblasts: sphingosine inhibits prostaglandin F(2alpha)-induced phosphoinositide hydrolysis.
Topics: Animals; Blotting, Western; Dinoprost; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Hydrolysis; Imidazoles; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositols; Phosphorylation; Pyridines; Signal Transduction; Sodium Fluoride; Sphingosine; Time Factors | 2000 |
Enhancement by sphingosine 1-phosphate in vasopressin-induced phosphoinositide hydrolysis in aortic smooth-muscle cells: involvement of p38 MAP kinase.
Topics: Aorta; Arginine Vasopressin; Cell Line; Enzyme Inhibitors; Flavonoids; Hydrolysis; Imidazoles; Lysophospholipids; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphatidylinositols; Phosphorylation; Pyridines; Sodium Fluoride; Sphingosine; Tumor Necrosis Factor-alpha; Virulence Factors, Bordetella | 2000 |
Tumor necrosis factor-alpha-induced cyclooxygenase-2 expression via sequential activation of ceramide-dependent mitogen-activated protein kinases, and IkappaB kinase 1/2 in human alveolar epithelial cells.
Topics: Cell Nucleus; Ceramides; Cyclooxygenase 2; Drug Interactions; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Epithelium; Flavonoids; Humans; I-kappa B Kinase; Imidazoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Membrane Proteins; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Mutation; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Pulmonary Alveoli; Pyridines; Sphingomyelin Phosphodiesterase; Sphingosine; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2001 |
Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Astrocytes; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cycloheximide; Enkephalins; Enzyme Inhibitors; Flavonoids; Gene Expression; Imidazoles; Isoquinolines; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Protein Precursors; Protein Synthesis Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingosine; Stimulation, Chemical; Sulfonamides; Transcription Factor AP-1 | 2001 |
Ceramide-induced apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Ceramides; Cerebral Cortex; Down-Regulation; Enzyme Inhibitors; Fetus; Imidazoles; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyridines; RNA; Sphingomyelins; Sphingosine; Tumor Suppressor Protein p53; Up-Regulation | 2001 |
Apoptosis of human hepatic myofibroblasts promotes activation of matrix metalloproteinase-2.
Topics: Apoptosis; Cells, Cultured; Cytochalasin D; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation, Enzymologic; Hepatocytes; Humans; Imidazoles; Matrix Metalloproteinase 2; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Mitogen-Activated Protein Kinases; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Pyridines; RNA, Messenger; Sphingosine | 2002 |
C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis.
Topics: Animals; Apoptosis; Blotting, Western; Cell Survival; Ceramides; Cerebral Cortex; Culture Media, Serum-Free; Culture Techniques; DNA-Binding Proteins; Early Growth Response Protein 1; Embryo, Mammalian; Enzyme Inhibitors; Female; Gene Expression Regulation; Green Fluorescent Proteins; Imidazoles; Immediate-Early Proteins; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Luminescent Proteins; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pregnancy; Proteins; Proto-Oncogene Proteins c-jun; Pyridines; Sphingosine; Subcellular Fractions; Time Factors; Transcription Factors; Transfection | 2003 |
Sphingosine 1-phosphate antagonizes human neutrophil apoptosis via p38 mitogen-activated protein kinase.
Topics: Apoptosis; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Lysophospholipids; Mitogen-Activated Protein Kinases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Signal Transduction; Sphingosine | 2003 |
Sphingosine-1-phosphate-induced ERK activation protects human melanocytes from UVB-induced apoptosis.
Topics: Anthracenes; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cell Survival; Cytoprotection; Dose-Response Relationship, Radiation; Enzyme Activation; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Korea; Lysophospholipids; Melanocytes; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Pyridines; Sphingosine; Ultraviolet Rays | 2003 |
Expression of adhesion molecules by sphingosine 1-phosphate and histamine in endothelial cells.
Topics: Acetophenones; Benzopyrans; Blotting, Western; Carbazoles; Cell Adhesion Molecules; Cells, Cultured; E-Selectin; Endothelium, Vascular; Estrenes; Histamine; Histamine Agonists; Humans; Imidazoles; Indoles; Intercellular Adhesion Molecule-1; Lysophospholipids; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Pyridines; Pyrrolidinones; RNA, Messenger; Signal Transduction; Sphingosine; Type C Phospholipases; Umbilical Veins; Vascular Cell Adhesion Molecule-1 | 2004 |
Interleukin (IL)-17 enhances tumor necrosis factor-alpha-stimulated IL-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts.
Topics: Animals; Anisomycin; Cell Line; Dose-Response Relationship, Drug; Imidazoles; Interleukin-17; Interleukin-6; Lysophospholipids; Mice; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Sphingosine; Tumor Necrosis Factor-alpha | 2004 |
High sensitivity of fibroblast cell lines derived from LEC rats to heat treatment.
Topics: Animals; Anthracenes; Apoptosis; Cell Line; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Fibroblasts; Flow Cytometry; Hot Temperature; HSP70 Heat-Shock Proteins; Imidazoles; Immunoblotting; Pyridines; Rats; Rats, Inbred LEC; Sphingosine; Time Factors | 2004 |
Involvement of p38 MAP kinase-mediated cytochrome c release on sphingosine-1-phosphate (S1P)- and N-monomethyl-S1P-induced cell death of PC12 cells.
Topics: Animals; Cell Death; Cytochromes c; Dose-Response Relationship, Drug; Imidazoles; Lysophospholipids; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Pyridines; Rats; Sphingosine | 2005 |
Intracellular signal transduction for migration and actin remodeling in vascular smooth muscle cells after sphingosylphosphorylcholine stimulation.
Topics: Actins; Amides; Animals; Azepines; Cell Movement; Cells, Cultured; Cytoskeleton; Enzyme Inhibitors; GTP-Binding Proteins; Guinea Pigs; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth, Vascular; Myosin Light Chains; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Phosphorylcholine; Pyridines; Signal Transduction; Sphingosine | 2006 |
S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells.
Topics: Blotting, Western; Calcium; Cell Line, Tumor; Cell Movement; Chemotaxis; Chromones; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Lysophospholipids; Morpholines; Neoplasm Invasiveness; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Protein Isoforms; Proto-Oncogene Proteins c-akt; Pyridines; Receptors, Lysosphingolipid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sphingosine | 2007 |
Human apolipoprotein A-I induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through ATP-binding cassette transporter A1.
Topics: Apolipoprotein A-I; Apolipoproteins; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Cells, Cultured; Cholesterol; Cyclooxygenase 2; Down-Regulation; Drug Synergism; Epoprostenol; Extracellular Signal-Regulated MAP Kinases; Fatty Acids, Nonesterified; Flavonoids; Gene Expression; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Janus Kinase 2; Lipoproteins, HDL; Lysophospholipids; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phospholipids; Phosphorylation; Protein Kinase Inhibitors; Pyridines; RNA, Small Interfering; Signal Transduction; Sphingosine; Trypsin; Tyrphostins; Up-Regulation | 2011 |
Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement.
Topics: Actins; Amides; Antigens, CD; Bacterial Proteins; Bacterial Toxins; Cadherins; Cell Membrane; Cells, Cultured; Chelating Agents; Cytoskeletal Proteins; Cytoskeleton; Egtazic Acid; Electric Impedance; Endothelial Cells; Gene Knockdown Techniques; Humans; Imidazoles; Lysophospholipids; Membrane Proteins; Microfilament Proteins; Oxadiazoles; p38 Mitogen-Activated Protein Kinases; Permeability; Phosphorylation; Protein Kinase C; Pulmonary Artery; Pyridines; Receptors, Lysosphingolipid; rho GTP-Binding Proteins; rho-Associated Kinases; RNA Interference; Sphingosine; Thiophenes | 2011 |
S1P2 receptor mediates sphingosine-1-phosphate-induced fibronectin expression via MAPK signaling pathway in mesangial cells under high glucose condition.
Topics: Animals; Diabetic Nephropathies; Extracellular Matrix; Extracellular Signal-Regulated MAP Kinases; Fibronectins; Flavonoids; Glucose; Hyperglycemia; Imidazoles; Kidney; Lysophospholipids; MAP Kinase Signaling System; Mesangial Cells; p38 Mitogen-Activated Protein Kinases; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; RNA Interference; RNA, Messenger; RNA, Small Interfering; Sphingosine; Sphingosine-1-Phosphate Receptors | 2012 |
Regulation of interleukin-1alpha and tumor necrosis factor-alpha-induced interleukin-8 production by amnion-derived (WISH) cells.
Topics: Amnion; Butadienes; Cell Line; Enzyme Inhibitors; Fumonisins; Humans; Imidazoles; Interleukin 1 Receptor Antagonist Protein; Interleukin-1alpha; Interleukin-8; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Pyridines; Sphingosine; Tumor Necrosis Factor-alpha | 2012 |
Sphingosine-1-phosphate modulates expression of vascular endothelial growth factor in human articular chondrocytes: a possible new role in arthritis.
Topics: Aged; Cartilage, Articular; Cells, Cultured; Chondrocytes; Drug Interactions; Enzyme Inhibitors; Female; Fingolimod Hydrochloride; Flavonoids; Gene Expression; Humans; Imidazoles; Immunosuppressive Agents; Lysophospholipids; Male; Mitogen-Activated Protein Kinases; Osteoarthritis; Pertussis Toxin; Propylene Glycols; Pyridines; RNA, Messenger; Sphingosine; Vascular Endothelial Growth Factor A | 2012 |