sb 203580 has been researched along with sk&f 86002 in 14 studies
| Studies (sb 203580) | Trials (sb 203580) | Recent Studies (post-2010) (sb 203580) | Studies (sk&f 86002) | Trials (sk&f 86002) | Recent Studies (post-2010) (sk&f 86002) |
|---|---|---|---|---|---|
| 3,489 | 4 | 1,137 | 83 | 4 | 13 |
| Protein | Taxonomy | sb 203580 (IC50) | sk&f 86002 (IC50) |
|---|---|---|---|
| Mitogen-activated protein kinase 13 | Homo sapiens (human) | 3.8 | |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | 5.4 | |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | 10 | |
| Mitogen-activated protein kinase 12 | Homo sapiens (human) | 3.8 | |
| Mitogen-activated protein kinase 11 | Homo sapiens (human) | 3.8 | |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | 2.1217 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 10 (71.43) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adams, JL; Badger, AM; Boehm, JC; Bradbeer, J; Breton, JJ; Chabot-Fletcher, MC; Gallagher, TF; Garigipati, RS; Griswold, DE; Hillegass, LM; Laydon, JT; Lee, JC; Sheldrake, PL; Smietana, JM; Sorenson, ME | 1 |
| Laufer, SA; Wagner, GK | 1 |
| Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A | 1 |
| Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ | 1 |
| Baillargeon, J; Cleland, LG; James, MJ; Lee, JC; Pouliot, M | 1 |
| de Caestecker, MP; Watanabe, H; Yamada, Y | 1 |
| Cara, DC; Forster, M; Kaur, J; Kubes, P; McCafferty, DM | 1 |
| Cao, BZ; Jing, Q; Lei, ZB; Li, XY; Pei, G; Qin, YW; Zhang, Z | 1 |
| Kaur, J; Kubes, P; Woodman, RC | 1 |
| Blaschke, F; Bruemmer, D; Kintscher, U; Law, RE; Unger, T | 1 |
| Guinea Viniegra, J; Hernández Losa, J; Parada Cobo, C; Ramón y Cajal, S; Sánchez-Arevalo Lobo, VJ; Sánchez-Prieto, R | 1 |
| Bukhtiyarova, M; Casper, D; Springman, EB | 1 |
| Ramesh, G; Reeves, WB | 1 |
| Laufer, S; Wagner, G | 1 |
1 review(s) available for sb 203580 and sk&f 86002
| Article | Year |
|---|---|
Small molecular anti-cytokine agents.
Topics: ADAM Proteins; ADAM17 Protein; Animals; Caspase Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytokines; Humans; Hydroxamic Acids; Imidazoles; Matrix Metalloproteinase Inhibitors; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridazines; Pyridines; Pyrimidines; Quinazolines; Structure-Activity Relationship; Succinates; Thiazoles; Tumor Necrosis Factor-alpha; Urea | 2006 |
13 other study(ies) available for sb 203580 and sk&f 86002
| Article | Year |
|---|---|
1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arthritis; Bone Density; Cyclooxygenase Inhibitors; Cytokines; Imidazoles; Lipoxygenase Inhibitors; Mice; Mice, Inbred BALB C; Molecular Structure; Morpholines; Prostaglandin-Endoperoxide Synthases; Protein Kinases; Rats; Structure-Activity Relationship; Tumor Necrosis Factor-alpha | 1996 |
From imidazoles to pyrimidines: new inhibitors of cytokine release.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Enzyme Inhibitors; Humans; Imidazoles; In Vitro Techniques; Interleukin-1; Leukocytes, Mononuclear; Mitogen-Activated Protein Kinases; Models, Molecular; p38 Mitogen-Activated Protein Kinases; Pyrimidines; Structure-Activity Relationship; Sulfoxides; Tumor Necrosis Factor-alpha | 2002 |
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase | 2013 |
Identification of potent Yes1 kinase inhibitors using a library screening approach.
Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship | 2013 |
Inhibition of prostaglandin endoperoxide synthase-2 expression in stimulated human monocytes by inhibitors of p38 mitogen-activated protein kinase.
Topics: Arachidonate 5-Lipoxygenase; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Interleukin-1; Mitogen-Activated Protein Kinases; Monocytes; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Pyridines; RNA, Messenger; Thiazoles | 1997 |
Transcriptional cross-talk between Smad, ERK1/2, and p38 mitogen-activated protein kinase pathways regulates transforming growth factor-beta-induced aggrecan gene expression in chondrogenic ATDC5 cells.
Topics: Aggrecans; Animals; Butadienes; Cell Differentiation; Cell Line; Cell Nucleus; Chondrocytes; Cycloheximide; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Matrix Proteins; Gene Expression Regulation, Enzymologic; Genes, Dominant; Imidazoles; Immunoblotting; Lectins, C-Type; Luciferases; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Synthesis Inhibitors; Proteoglycans; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Smad Proteins; Thiazoles; Time Factors; Trans-Activators; Transcription, Genetic; Transfection; Transforming Growth Factor beta | 2001 |
Role of p38 mitogen-activated protein kinase in chemokine-induced emigration and chemotaxis in vivo.
Topics: Animals; Cell Adhesion; Chemokine CXCL1; Chemokines; Chemokines, CXC; Chemotaxis, Leukocyte; Cytokines; Enzyme Inhibitors; Imidazoles; Infusions, Intravenous; Injections, Intravenous; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Microscopy, Video; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Neutrophil Infiltration; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Thiazoles | 2001 |
OxLDL upregulates CXCR2 expression in monocytes via scavenger receptors and activation of p38 mitogen-activated protein kinase.
Topics: Cell Adhesion; Chemotaxis, Leukocyte; Coculture Techniques; Dextran Sulfate; Endothelium, Vascular; Enzyme Activation; Flow Cytometry; Humans; Imidazoles; Interleukin-8; Lipoproteins, LDL; Membrane Proteins; Mitogen-Activated Protein Kinases; Monocytes; p38 Mitogen-Activated Protein Kinases; Poly I; Pyridines; Receptors, Immunologic; Receptors, Interleukin-8B; Receptors, Lipoprotein; Receptors, Scavenger; RNA, Messenger; Scavenger Receptors, Class B; Thiazoles; U937 Cells | 2002 |
P38 MAPK: critical molecule in thrombin-induced NF-kappa B-dependent leukocyte recruitment.
Topics: Adenosine Triphosphate; Binding Sites; Binding, Competitive; Cell Adhesion; Cells, Cultured; E-Selectin; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Leukocytes; Mitogen-Activated Protein Kinases; NF-kappa B; P-Selectin; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Thiazoles; Thrombin; Umbilical Veins | 2003 |
p38 MAP kinase negatively regulates angiotensin II-mediated effects on cell cycle molecules in human coronary smooth muscle cells.
Topics: Angiotensin II; Cell Cycle; Cells, Cultured; Cyclin D1; DNA; Enzyme Inhibitors; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Retinoblastoma Protein; Thiazoles | 2003 |
Role of the p38 MAPK pathway in cisplatin-based therapy.
Topics: Animals; Antineoplastic Agents; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Survival; Cisplatin; COS Cells; Cross-Linking Reagents; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; HeLa Cells; Humans; Imidazoles; Kinetics; MAP Kinase Kinase 3; MAP Kinase Kinase 6; Mitogen-Activated Protein Kinase 12; Mitogen-Activated Protein Kinase 13; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phenotype; Phosphorylation; Plasmids; Platinum Compounds; Precipitin Tests; Protein Isoforms; Protein-Tyrosine Kinases; Pyridines; Signal Transduction; Thiazoles; Transfection; Tumor Cells, Cultured | 2003 |
A Biacore biosensor method for detailed kinetic binding analysis of small molecule inhibitors of p38alpha mitogen-activated protein kinase.
Topics: Animals; Escherichia coli; Imidazoles; Kinetics; Mice; Mitogen-Activated Protein Kinases; Molecular Structure; Phosphorylation; Protein Binding; Protein Denaturation; Pyridines; Recombinant Proteins; Surface Plasmon Resonance; Thiazoles | 2004 |
p38 MAP kinase inhibition ameliorates cisplatin nephrotoxicity in mice.
Topics: Animals; Cell Line; Cisplatin; Enzyme Activation; Enzyme Inhibitors; Free Radical Scavengers; Imidazoles; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; Thiazoles; Thiourea; Tumor Necrosis Factor-alpha | 2005 |