Page last updated: 2024-09-05

sb 203580 and sirolimus

sb 203580 has been researched along with sirolimus in 37 studies

Compound Research Comparison

Studies (sb 203580)	Trials (sb 203580)	Recent Studies (post-2010) (sb 203580)	Studies (sirolimus)	Trials (sirolimus)	Recent Studies (post-2010) (sirolimus)
3,489	4	1,137	20,711	2,368	11,516

Protein Interaction Comparison

Protein	Taxonomy	sirolimus (IC50)
Bile salt export pump	Homo sapiens (human)	10
ATP-dependent translocase ABCB1	Homo sapiens (human)	1.25
Cytochrome P450 3A4	Homo sapiens (human)	2
Cytochrome P450 2C9	Homo sapiens (human)	2
Peptidyl-prolyl cis-trans isomerase FKBP1A	Mus musculus (house mouse)	0.001
Cytochrome P450 2C19	Homo sapiens (human)	4
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	0.0897
Peptidyl-prolyl cis-trans isomerase FKBP1A	Homo sapiens (human)	0.0042
Regulatory-associated protein of mTOR	Homo sapiens (human)	0.225
Target of rapamycin complex subunit LST8	Homo sapiens (human)	0.225
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	1.9
Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)	1.1

Research

Studies (37)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (10.81)	18.2507
2000's	23 (62.16)	29.6817
2010's	9 (24.32)	24.3611
2020's	1 (2.70)	2.80

Authors

Authors	Studies
Caivano, M; Cohen, P; Davies, SP; Reddy, H	1
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H	1
Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N	1
Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A	1
Laufer, S; Pillaiyar, T	1
Klip, A; McCall, A; Taha, C; Tsakiridis, T	1
Bushell, M; McKendrick, L; Morley, SJ	1
Cohen, P; Cuenda, A	1
Fraser, CS; Morley, SJ; Pain, VM	1
Bansal, R; Baron, W; de Vries, H; Hoekstra, D; Metz, B	1
Alessi, DR; Cuenda, A	1
Fando, JL; Martín, ME; Muñoz, FM; Salinas, M	1
Chen, CS; Dods, P; Gagnon, A; Roustan-Delatour, N; Sorisky, A	1
Callery, MP; Elbirt, KK; Potter, MW; Shah, SA	1
Inaguma, Y; Ito, H; Iwamoto, I; Kamei, K; Kato, K	1
López-Rovira, T; Rosa, JL; Ventura, F; Viñals, F	1
Cruciani, V; Mikalsen, SO	1
Eggo, MC; Holder, JC; Kumar, S; Patel, NG; Smith, SA	1
Akamatsu, S; Hatakeyama, D; Kozawa, O; Oiso, Y; Shibata, T; Tokuda, H	1
Angelovska, T; Borowiec, AM; Dixon, IM; Freed, DH	1
Allen, WE; Campbell, M; Sawyer, C; Trimble, ER; Vanhaesebroeck, B	1
Martín, ME; O'Loghlen, A; Pérez-Morgado, MI; Salinas, M	1
Funk, AP; Gera, JF; Jo, OD; Marderosian, M; Masri, J; Sharma, A; Vartanian, R	1
Babó, I; Harisi, R; Jeney, A; Kenessey, I; Oláh, J; Pogány, G; Timár, F	1
Hosoi, H; Houghton, PJ; Misawa-Furihata, A; Sugimoto, T; Tsuchiya, K	1
Han, HJ; Lee, MY; Lee, SH	1
Carreira, RS; Glembotski, CC; Gottlieb, RA; Huang, C; Iwai-Kanai, E; Perry, CN; Yuan, H	1
Asano, S; Itoh, M; Nishiwaki-Yasuda, K; Sekiguchi, S; Shibata, M; Suzuki, A	1
Li, XM; Shen, HM; Wang, XY; Xiao, L; Xu, CF; Yang, YB	1
Blanc, M; Cordier-Bussat, M; Couderc, C; Gouysse, G; Nejjari, M; Roche, C; Scoazec, JY; Vercherat, C; Villaume, K; Walter, T	1
Banerjee, K; Ghosh, P; Longo, DL; Munk, RB; Rezanka, L; Sasaki, CY; Sen, R; Sugiyama, K; Takahashi, H	1
Frost, P; Fukunaga, R; Gera, J; Hoang, B; Lichtenstein, A; Shi, Y; Yang, Y	1
Chauski, EI; Khaliulin, IG; Maslov, LN; Mukhomedzyanov, AV; Portnichenko, AG; Tsibulnikov, SY	1
Chauhan, A; Mishra, SP; Ojha, R; Semwal, DK; Semwal, RB	1
Al Mamun Bhuyan, A; Cao, H; Lang, F	1
Fujita, K; Kainuma, S; Kawabata, T; Kozawa, O; Kuroyanagi, G; Matsushima-Nishiwaki, R; Otsuka, T; Sakai, G; Tokuda, H; Yamamoto, N	1
Bae, SC; Chi, XZ; Hyun, JW; Ito, Y; Jang, JW; Kim, DM; Lee, JW; Lee, YS; Park, IY; Park, TG; Song, SH	1

Reviews

3 review(s) available for sb 203580 and sirolimus

Article	Year
Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy. Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2 Topics: Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Humans; Protein Kinase Inhibitors; SARS-CoV-2; Signal Transduction; Virus Replication	2022
Use of kinase inhibitors to dissect signaling pathways. Methods in molecular biology (Clifton, N.J.), 2000, Volume: 99 Topics: Androstadienes; Animals; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Maleimides; Morpholines; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Sirolimus; Wortmannin	2000
[Study of drugs against neoplastic metastasis]. Magyar onkologia, 2006, Volume: 50, Issue:2 Topics: Animals; Antineoplastic Agents; Cell Movement; Chromones; Deoxyuridine; Doxorubicin; Enzyme Inhibitors; Fatty Alcohols; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Morpholines; Neoplasm Metastasis; Paclitaxel; Pyridines; Ribavirin; Signal Transduction; Sirolimus	2006

Other Studies

34 other study(ies) available for sb 203580 and sirolimus

Article	Year
Specificity and mechanism of action of some commonly used protein kinase inhibitors. The Biochemical journal, 2000, Oct-01, Volume: 351, Issue:Pt 1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides	2000
Identifying off-target effects and hidden phenotypes of drugs in human cells. Nature chemical biology, 2006, Volume: 2, Issue:6 Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship	2006
The selectivity of protein kinase inhibitors: a further update. The Biochemical journal, 2007, Dec-15, Volume: 408, Issue:3 Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera	2007
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. The Biochemical journal, 2013, Apr-15, Volume: 451, Issue:2 Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase	2013
Glucose transporter expression in L6 muscle cells: regulation through insulin- and stress-activated pathways. The American journal of physiology, 1997, Volume: 273, Issue:1 Pt 1 Topics: 2,4-Dinitrophenol; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Line; Enzyme Inhibitors; Flavonoids; Glucose Transporter Type 1; Glucose Transporter Type 3; Hypertonic Solutions; Imidazoles; Insulin; Kinetics; Mannitol; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Monosaccharide Transport Proteins; Muscle, Skeletal; Nerve Tissue Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Polyenes; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Stress, Physiological; Uncoupling Agents	1997
Cleavage of translation initiation factor 4G (eIF4G) during anti-Fas IgM-induced apoptosis does not require signalling through the p38 mitogen-activated protein (MAP) kinase. FEBS letters, 1998, Oct-30, Volume: 438, Issue:1-2 Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Arsenites; Calcium-Calmodulin-Dependent Protein Kinases; Caspase Inhibitors; Cell Survival; Etoposide; Eukaryotic Initiation Factor-4E; Eukaryotic Initiation Factor-4G; fas Receptor; Humans; Imidazoles; Immunoglobulin M; Jurkat Cells; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Peptide Initiation Factors; Phosphorylation; Poly(A)-Binding Proteins; Protein Biosynthesis; Pyridines; RNA-Binding Proteins; Signal Transduction; Sirolimus	1998
Stress-activated protein kinase-2/p38 and a rapamycin-sensitive pathway are required for C2C12 myogenesis. The Journal of biological chemistry, 1999, Feb-12, Volume: 274, Issue:7 Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Line; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; Intracellular Signaling Peptides and Proteins; Mice; Mitogen-Activated Protein Kinase 12; Mitogen-Activated Protein Kinases; Muscle Development; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Ribosomal Protein S6 Kinases; Sirolimus	1999
Cellular stress in xenopus kidney cells enhances the phosphorylation of eukaryotic translation initiation factor (eIF)4E and the association of eIF4F with poly(A)-binding protein. The Biochemical journal, 1999, Sep-15, Volume: 342 Pt 3 Topics: Animals; Anisomycin; Arsenites; Cells, Cultured; Chromones; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Eukaryotic Initiation Factor-4F; Hot Temperature; Imidazoles; Kidney; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Peptide Initiation Factors; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Poly(A)-Binding Proteins; Protein Kinases; Pyridines; RNA-Binding Proteins; Sirolimus; TOR Serine-Threonine Kinases; Xenopus laevis	1999
PDGF and FGF-2 signaling in oligodendrocyte progenitor cells: regulation of proliferation and differentiation by multiple intracellular signaling pathways. Molecular and cellular neurosciences, 2000, Volume: 15, Issue:3 Topics: Animals; Cell Differentiation; Cell Division; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Estrenes; Fibroblast Growth Factor 2; Flavonoids; Genistein; Imidazoles; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Myristoylated Alanine-Rich C Kinase Substrate; Nerve Tissue Proteins; Oligodendroglia; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Protein Processing, Post-Translational; Proteins; Pyridines; Pyrrolidinones; Rats; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Stem Cells	2000
Ischaemia induces changes in the association of the binding protein 4E-BP1 and eukaryotic initiation factor (eIF) 4G to eIF4E in differentiated PC12 cells. The Biochemical journal, 2000, Oct-15, Volume: 351 Pt 2 Topics: Animals; Antibiotics, Antineoplastic; Carrier Proteins; Cell Survival; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Eukaryotic Initiation Factor-4G; Flavonoids; Glucose; Hypoxia; Imidazoles; Intracellular Signaling Peptides and Proteins; Ischemia; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Peptide Initiation Factors; Phosphoproteins; Phosphorylation; Protein Binding; Protein Synthesis Inhibitors; Pyridines; Rats; Sirolimus; Time Factors	2000
Phosphatidylinositol-3,4,5-trisphosphate is required for insulin-like growth factor 1-mediated survival of 3T3-L1 preadipocytes. Endocrinology, 2001, Volume: 142, Issue:1 Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; Apoptosis; Chromones; Culture Media, Serum-Free; Enzyme Inhibitors; Flavonoids; Imidazoles; In Situ Nick-End Labeling; Insulin-Like Growth Factor I; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Sirolimus; Wortmannin	2001
Endotoxin (LPS) stimulates 4E-BP1/PHAS-I phosphorylation in macrophages. The Journal of surgical research, 2001, May-01, Volume: 97, Issue:1 Topics: Animals; Carrier Proteins; Cell Line; Cells, Cultured; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Flavonoids; Imidazoles; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Macrophages; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; p38 Mitogen-Activated Protein Kinases; Peptide Initiation Factors; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Pyridines; Rats; Sirolimus	2001
Regulation of the levels of small heat-shock proteins during differentiation of C2C12 cells. Experimental cell research, 2001, Jun-10, Volume: 266, Issue:2 Topics: Animals; Blotting, Northern; Blotting, Western; Cell Differentiation; Cell Line; Creatine Kinase; Creatine Kinase, MM Form; Crystallins; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Heat Shock Transcription Factors; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Imidazoles; Isoenzymes; Mice; Molecular Chaperones; Muscle, Skeletal; Neoplasm Proteins; Protein Kinase Inhibitors; Pyridines; RNA, Messenger; Sirolimus; Transcription Factors	2001
Inhibition of PI3K/p70 S6K and p38 MAPK cascades increases osteoblastic differentiation induced by BMP-2. FEBS letters, 2002, Jan-02, Volume: 510, Issue:1-2 Topics: Alkaline Phosphatase; Animals; Biomarkers; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Differentiation; Chromones; Core Binding Factor Alpha 1 Subunit; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neoplasm Proteins; Osteoblasts; Osteocalcin; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Transcription Factors; Transforming Growth Factor beta	2002
Mechanisms involved in responses to the poroxisome proliferator WY-14,643 on gap junctional intercellular communication in V79 hamster fibroblasts. Toxicology and applied pharmacology, 2002, Jul-01, Volume: 182, Issue:1 Topics: Acetophenones; Androstadienes; Animals; Benzopyrans; Brefeldin A; Butadienes; Cell Communication; Cells, Cultured; Cricetinae; Cricetulus; Enzyme Inhibitors; Flavonoids; Gap Junctions; Imidazoles; Indoles; Maleimides; Mesocricetus; Mitogen-Activated Protein Kinases; Nitriles; Peroxisome Proliferators; Protein Kinase C; Protein Synthesis Inhibitors; Pyridines; Pyrimidines; Signal Transduction; Sirolimus; Wortmannin	2002
Differential regulation of lipogenesis and leptin production by independent signaling pathways and rosiglitazone during human adipocyte differentiation. Diabetes, 2003, Volume: 52, Issue:1 Topics: Adipocytes; Androstadienes; Cell Differentiation; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Leptin; Lipid Metabolism; Lipids; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Rosiglitazone; Signal Transduction; Sirolimus; Stem Cells; Thiazoles; Thiazolidinediones; Tumor Necrosis Factor-alpha; Wortmannin	2003
p38 MAP kinase regulates BMP-4-stimulated VEGF synthesis via p70 S6 kinase in osteoblasts. American journal of physiology. Endocrinology and metabolism, 2003, Volume: 284, Issue:6 Topics: Animals; Anisomycin; Anti-Bacterial Agents; Blotting, Western; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Butadienes; Cell Line; Chromones; Endothelial Growth Factors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Imidazoles; Intercellular Signaling Peptides and Proteins; Lymphokines; Mice; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Biosynthesis; Protein Synthesis Inhibitors; Proteins; Pyridines; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2003
Induction of protein synthesis in cardiac fibroblasts by cardiotrophin-1: integration of multiple signaling pathways. Cardiovascular research, 2003, Nov-01, Volume: 60, Issue:2 Topics: Animals; Blotting, Western; Cells, Cultured; Chromones; Cytokines; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Imidazoles; Janus Kinase 1; Male; MAP Kinase Signaling System; Morpholines; Myocardium; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Precipitin Tests; Protein Biosynthesis; Protein-Tyrosine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirolimus; Tyrphostins	2003
Glucose-potentiated chemotaxis in human vascular smooth muscle is dependent on cross-talk between the PI3K and MAPK signaling pathways. Circulation research, 2004, Aug-20, Volume: 95, Issue:4 Topics: Alkyl and Aryl Transferases; Androstadienes; Anthracenes; Antibodies, Monoclonal; Cells, Cultured; Chemotaxis; Chromones; Class I Phosphatidylinositol 3-Kinases; Farnesyltranstransferase; Flavonoids; Glucose; Humans; Imidazoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Lovastatin; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Polyisoprenyl Phosphates; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; ras Proteins; Sesquiterpenes; Sirolimus; TOR Serine-Threonine Kinases; Wortmannin	2004
N-acetyl-cysteine abolishes hydrogen peroxide-induced modification of eukaryotic initiation factor 4F activity via distinct signalling pathways. Cellular signalling, 2006, Volume: 18, Issue:1 Topics: Acetylcysteine; Animals; Carrier Proteins; Eukaryotic Initiation Factor-4F; Eukaryotic Initiation Factor-4G; Hydrogen Peroxide; Imidazoles; Intracellular Signaling Peptides and Proteins; Okadaic Acid; PC12 Cells; Phosphoproteins; Pyridines; Rats; Signal Transduction; Sirolimus	2006
Tristetraprolin regulates Cyclin D1 and c-Myc mRNA stability in response to rapamycin in an Akt-dependent manner via p38 MAPK signaling. Oncogene, 2006, Oct-12, Volume: 25, Issue:47 Topics: 14-3-3 Proteins; Animals; Cell Line; Cyclin D; Cyclins; Dactinomycin; Embryo, Mammalian; Fibroblasts; Genes, bcl-1; Genes, myc; Genes, Reporter; Half-Life; Imidazoles; Mice; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphoserine; Protein Binding; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Pyridines; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Ribosomes; RNA Interference; RNA, Messenger; RNA, Small Interfering; Sirolimus; Tristetraprolin	2006
Insulin-like growth factor-I has different effects on myogenin induction and cell cycle progression in human alveolar and embryonal rhabdomyosarcoma cells. International journal of oncology, 2007, Volume: 31, Issue:1 Topics: Antibiotics, Antineoplastic; Antibodies, Monoclonal; Cell Cycle; Cell Line, Tumor; Humans; Imidazoles; Insulin-Like Growth Factor I; Muscle Development; Myogenin; Protein Biosynthesis; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Receptor, IGF Type 1; Rhabdomyosarcoma, Alveolar; Rhabdomyosarcoma, Embryonal; Sirolimus; TOR Serine-Threonine Kinases	2007
Short-period hypoxia increases mouse embryonic stem cell proliferation through cooperation of arachidonic acid and PI3K/Akt signalling pathways. Cell proliferation, 2008, Volume: 41, Issue:2 Topics: Animals; Arachidonic Acid; Ascorbic Acid; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Chromones; Cyclin D1; Cyclin E; Cyclin-Dependent Kinases; Embryonic Stem Cells; Flavonoids; G1 Phase; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phospholipases A2, Cytosolic; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Up-Regulation	2008
LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection. American journal of physiology. Heart and circulatory physiology, 2009, Volume: 296, Issue:2 Topics: Acetylcysteine; Animals; Animals, Newborn; Antioxidants; Autophagy; Cells, Cultured; Cytoprotection; Enzyme Inhibitors; Glutathione; Hydrogen Peroxide; Imidazoles; Lipopolysaccharides; Mice; Mice, Transgenic; Mitochondria, Heart; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Signal Transduction; Sirolimus; Tumor Necrosis Factor-alpha; Tyrphostins	2009
Effects of prostaglandin D2 on Na-dependent phosphate transport activity and its intracellular signaling mechanism in osteoblast-like cells. Prostaglandins, leukotrienes, and essential fatty acids, 2009, Volume: 81, Issue:4 Topics: 3T3 Cells; Animals; Anthracenes; Butadienes; Cells, Cultured; Chromones; Dose-Response Relationship, Drug; Imidazoles; Mice; Morpholines; Naphthalenes; Nitriles; Osteoblasts; Phosphates; Prostaglandin D2; Pyridines; Signal Transduction; Sirolimus; Sodium	2009
[Effect of signal transduction inhibitors on human endometrial carcinoma cells with differential PTEN gene expression]. Zhonghua fu chan ke za zhi, 2009, Volume: 44, Issue:9 Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Endometrial Neoplasms; Enzyme Inhibitors; ErbB Receptors; Female; Humans; Imidazoles; PTEN Phosphohydrolase; Pyridines; Signal Transduction; Sirolimus; Transfection; Tyrphostins	2009
VEGF secretion by neuroendocrine tumor cells is inhibited by octreotide and by inhibitors of the PI3K/AKT/mTOR pathway. Neuroendocrinology, 2010, Volume: 91, Issue:3 Topics: Animals; Cell Line, Tumor; Cell Survival; Chromones; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Insulin; Insulin Secretion; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 1; Mice; Morpholines; Neuroendocrine Tumors; Octreotide; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Rats; Sirolimus; Somatostatin; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor A	2010
Antigen-independent IFN-γ production by human naïve CD4 T cells activated by IL-12 plus IL-18. PloS one, 2011, May-10, Volume: 6, Issue:5 Topics: Animals; Antigens, Differentiation; CD4-Positive T-Lymphocytes; Cells, Cultured; Humans; Imidazoles; Interferon-gamma; Interleukin-12; Interleukin-18; Intracellular Signaling Peptides and Proteins; Male; Mice; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Polymerase Chain Reaction; Pyridines; Sirolimus; STAT4 Transcription Factor; TOR Serine-Threonine Kinases	2011
MNK kinases facilitate c-myc IRES activity in rapamycin-treated multiple myeloma cells. Oncogene, 2013, Jan-10, Volume: 32, Issue:2 Topics: 5' Untranslated Regions; Aniline Compounds; Animals; Butadienes; Cell Line, Tumor; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Genes, myc; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Mice; Multiple Myeloma; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Biosynthesis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-myc; Purines; Pyridines; RNA Interference; RNA, Messenger; RNA, Small Interfering; Sirolimus; TOR Serine-Threonine Kinases; Up-Regulation	2013
Role of MEK, PI3, p38, Tyrosine, and mTOR Kinases in Regulation of Heart Resistance to the Arrhythmogenic Action of Short-Term Ischemia and Reperfusion. Bulletin of experimental biology and medicine, 2015, Volume: 158, Issue:6 Topics: Animals; Arrhythmias, Cardiac; Flavonoids; Imidazoles; MAP Kinase Kinase Kinases; Myocardial Reperfusion Injury; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; Sirolimus; TOR Serine-Threonine Kinases	2015
Combined Treatment with CCI779 and SB203580 Induces Cellular Senescence in Renal Cell Carcinoma Cell Line via p53 Pathway. Anti-cancer agents in medicinal chemistry, 2017, Nov-24, Volume: 17, Issue:11 Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Renal Cell; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Imidazoles; Kidney Neoplasms; Molecular Structure; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Sirolimus; Structure-Activity Relationship; TOR Serine-Threonine Kinases; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2017
Triggering of Eryptosis, the Suicidal Erythrocyte Death by Mammalian Target of Rapamycin (mTOR) inhibitor Temsirolimus. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Volume: 42, Issue:4 Topics: Aniline Compounds; Annexin A5; Antineoplastic Agents; Benzamides; Benzophenanthridines; Calcium; Casein Kinase I; Caspases; Ceramides; Eryptosis; Erythrocytes; Fluoresceins; Gene Expression Regulation; Hemolysis; Humans; Imidazoles; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Phosphatidylserines; Primary Cell Culture; Protein Kinase Inhibitors; Pyridines; Reactive Oxygen Species; Signal Transduction; Sirolimus; Staurosporine; TOR Serine-Threonine Kinases; Xanthenes	2017
Heat shock protein 27 (HSPB1) suppresses the PDGF-BB-induced migration of osteoblasts. International journal of molecular medicine, 2017, Volume: 40, Issue:4 Topics: Animals; Anthracenes; Becaplermin; Cell Line; Cell Movement; Flavonoids; HSP27 Heat-Shock Proteins; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Osteoblasts; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-sis; Pyridines; Sirolimus	2017
RUNX3 regulates cell cycle-dependent chromatin dynamics by functioning as a pioneer factor of the restriction-point. Nature communications, 2019, 04-23, Volume: 10, Issue:1 Topics: Animals; Butadienes; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Chromatin; Chromatin Assembly and Disassembly; Core Binding Factor Alpha 3 Subunit; Cyclin-Dependent Kinase 4; Drosophila melanogaster; Epithelial Cells; Gene Expression Regulation; HEK293 Cells; Histone-Lysine N-Methyltransferase; Humans; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 4; Myeloid-Lymphoid Leukemia Protein; Nitriles; p38 Mitogen-Activated Protein Kinases; Piperazines; Polycomb-Group Proteins; Protein Kinase Inhibitors; Pyridines; ras Proteins; RNA, Small Interfering; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases	2019