sb 203580 has been researched along with simvastatin in 8 studies
| Studies (sb 203580) | Trials (sb 203580) | Recent Studies (post-2010) (sb 203580) | Studies (simvastatin) | Trials (simvastatin) | Recent Studies (post-2010) (simvastatin) |
|---|---|---|---|---|---|
| 3,489 | 4 | 1,137 | 8,442 | 1,730 | 3,630 |
| Protein | Taxonomy | sb 203580 (IC50) | simvastatin (IC50) |
|---|---|---|---|
| photoreceptor-specific nuclear receptor | Homo sapiens (human) | 1.164 | |
| transactivating tegument protein VP16 [Human herpesvirus 1] | Human alphaherpesvirus 1 (Herpes simplex virus type 1) | 4.426 | |
| Bile salt export pump | Homo sapiens (human) | 10 | |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Homo sapiens (human) | 0.7843 | |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | 9.5 | |
| Insulin receptor | Rattus norvegicus (Norway rat) | 0.0034 | |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | 0.0034 | |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Rattus norvegicus (Norway rat) | 0.0111 | |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | 0.049 | |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | 6.7 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H | 1 |
| Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ | 1 |
| Hatakeyama, D; Hirade, K; Ito, H; Kato, K; Kozawa, O; Niwa, M; Tokuda, H; Wang, X | 1 |
| Au, AL; Chan, SW; Chim, SS; Kwan, YW; Lam, TY; Lee, SM; Leung, GP; Seto, SW; Shigemura, N; Tjiu, DC; Tsui, SK; Wan, S; Yim, AP | 1 |
| Chen, H; Jin, WY; Ren, JY | 1 |
| Li, YB; Tian, H; Wang, HJ; Wang, J; Yang, M; Yin, JJ | 1 |
| Kowluru, A; Sidarala, V | 1 |
| Ayad, MT; Menon, R; Taylor, BD | 1 |
8 other study(ies) available for sb 203580 and simvastatin
| Article | Year |
|---|---|
Identifying off-target effects and hidden phenotypes of drugs in human cells.
Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship | 2006 |
Identification of potent Yes1 kinase inhibitors using a library screening approach.
Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship | 2013 |
Mechanism of simvastatin on induction of heat shock protein in osteoblasts.
Topics: 3T3 Cells; Animals; Cycloheximide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heat-Shock Proteins; Imidazoles; Lovastatin; Mice; Mitogen-Activated Protein Kinases; Osteoblasts; Osteogenesis; p38 Mitogen-Activated Protein Kinases; Pyridines; Reproducibility of Results; RNA, Messenger; Sensitivity and Specificity; Simvastatin | 2003 |
Modulation by simvastatin of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine coronary artery smooth muscle cells.
Topics: Adult; Aged; Animals; Blotting, Western; Caveolin 1; Cell Line; Cell Line, Tumor; Coronary Vessels; Dose-Response Relationship, Drug; Enzyme Activation; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; In Vitro Techniques; Male; Membrane Potentials; Middle Aged; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Peptides; Phorbol Esters; Potassium Channels, Calcium-Activated; Protein Kinase C-delta; Pyridines; Simvastatin; Swine | 2007 |
[Simvastatin suppress lipopolysaccharides induced upregulation of lipoprotein associated phospholipase A(2) expression in macrophages via inactivation of p38MAPK pathway].
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Anthracenes; Butadienes; Cells, Cultured; Humans; Imidazoles; Lipopolysaccharides; Macrophages; Monocytes; Nitriles; p38 Mitogen-Activated Protein Kinases; Phospholipases A2; Phosphorylation; Pyridines; RNA, Messenger; Simvastatin | 2010 |
Effect of simvastatin on expression of transforming growth factor-β and collagen type IV in rat mesangial cells.
Topics: Animals; Cells, Cultured; Collagen Type IV; Glucose; Glycation End Products, Advanced; Hydrogen Peroxide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Mesangial Cells; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Rats; Simvastatin; Transforming Growth Factor beta | 2011 |
Exposure to chronic hyperglycemic conditions results in Ras-related C3 botulinum toxin substrate 1 (Rac1)-mediated activation of p53 and ATM kinase in pancreatic β-cells.
Topics: Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Diabetes Mellitus, Type 2; Humans; Hyperglycemia; Imidazoles; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Morpholines; p38 Mitogen-Activated Protein Kinases; Prenylation; Pyridines; Pyrones; Quinolines; rac1 GTP-Binding Protein; Rats; Simvastatin; Tumor Suppressor Protein p53 | 2017 |
Regulation of p38 mitogen-activated kinase-mediated fetal membrane senescence by statins.
Topics: Adult; Cellular Senescence; Chorioallantoic Membrane; Extraembryonic Membranes; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pregnancy; Progesterone; Pyridines; Rosuvastatin Calcium; Simvastatin; Smoke; Young Adult | 2018 |