Compounds > sb 203580
Page last updated: 2024-09-05

sb 203580 and serine

sb 203580 has been researched along with serine in 55 studies

Compound Research Comparison

Studies
(sb 203580)		Trials
(sb 203580)		Recent Studies (post-2010)
(sb 203580)		Studies
(serine)		Trials
(serine)		Recent Studies (post-2010) (serine)
3,48941,13723,9141156,084

Protein Interaction Comparison

ProteinTaxonomysb 203580 (IC50)serine (IC50)
AcetylcholinesteraseElectrophorus electricus (electric eel)0.015
CholinesteraseEquus caballus (horse)0.016

Research

Studies (55)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (10.91)18.2507
2000's38 (69.09)29.6817
2010's9 (16.36)24.3611
2020's2 (3.64)2.80

Authors

AuthorsStudies
Cohen, P; Haavik, J; Thomas, G1
Frank, DA; Gollob, JA; Murphy, EA; Ritz, J; Schnipper, CP1
Iordanov, MS; Kapoor, M; Keller, D; Li, X; Lozano, G; Lu, H; Magun, B; Taya, Y; Zeng, X1
Cao, X; Lim, CP1
Goh, KC; Haque, SJ; Williams, BR1
Cohen, P; Decker, T; Eyers, PA; Gaestel, M; Kovarik, P; Menghini, R; Neininger, A; Stoiber, D1
Bergeron, DM; Chiles, TC; Swart, JM1
Bristol, JR; Chen, G; Fitzgibbon, MJ; Pazhanisamy, S; Porter, MD1
Dokter, WH; Jonk, LJ; Kruijer, W; Schuringa, JJ; Vellenga, E1
Coxon, PY; Klein, JB; McLeish, KR; Pierce, W; Ping, P; Powell, DW; Rane, MJ; Webster, R1
Adachi, M; Imai, K; Itoh, F; Nakahata, A; Nakayama, I; Takekawa, M; Taya, Y; Tsukuda, H1
Arkinstall, S; Cavalli, V; Corti, M; Gruenberg, J; Karin, M; Marcote, MJ; Tamura, K; Vilbois, F1
Brar, BK; Knight, RA; Latchman, DS; Matsumura, M; Nakanishi, Y; Scarabelli, TM; Stephanou, A1
Ammendola, S; Bonini, P; Cozzolino, F; De Chiara, G; Dello Sbarba, P; Garaci, E; Labardi, D; Lucibello, M; Marlier, LN; Nencioni, L; Palamara, AT; Rosini, P; Russo, T; Torcia, M; Zambrano, N1
Ando, M; Kishi, H; Matsumoto, M; Nakagawa, K; Suga, M; Taya, Y; Yamaizumi, M1
Geum, D; Kim, K; Son, GH1
Ewton, DZ; Friedman, E; Jin, K; Kim, GY; Mercer, SE; Yan, Z1
Horwitz, SB; Yang, CP1
Cohen, P; Haydon, CE; Knebel, A; Morrice, N1
Qu, X; Weber, HC; Xiao, D1
Cohen, P; Haavik, J; Kleppe, R; Toska, K1
Guan, KL; Inoki, K; Li, Y; Vacratsis, P1
De Wilde, G; Haegeman, G; Van Damme, P; Vanden Berghe, W; Vermeulen, L1
Griendling, KK; Rocic, P; Seshiah, P1
Jambal, P; Pugazhenthi, S; Reusch, JE; Vaishnav, D1
Chu, CY; Kuo, HC; Lee, YJ; Lin, WC; Tseng, TH; Wang, CJ1
Bianchi, E; Cheli, A; Denti, S; Fabbri, M; Innamorati, G; Pardi, R; Putignano, S; Rogge, L; Sirri, A1
D'Orazi, G; Di Stefano, V; Rinaldo, C; Sacchi, A; Soddu, S1
Ben-Ze'ev, A; Kosakowski, M; Lee, P; Libertino, JA; Moinzadeh, A; Rieger-Christ, KM; Stoffel, J; Summerhayes, IC; Zagha, R1
Hammerschmidt, S; Hippenstiel, S; Hocke, AC; Hoffmann, E; Huber, S; Kracht, M; Moog, K; Opitz, B; Rosseau, S; Schmeck, B; Suttorp, N; van Laak, V; Zahlten, J; Zerrahn, J1
Akamastu, S; Ishisaki, A; Kanno, Y; Kato, K; Kitajima, Y; Kozawa, O; Matsuno, H; Nakajima, K; Shu, E; Suga, H; Takai, S1
Franklin, RA; Howe, CJ; Lahair, MM; McCubrey, JA; Rodriguez-Mora, OG1
Billestrup, N; Bonny, C; Darville, M; Eizirik, DL; Larsen, L; Mandrup-Poulsen, T; Størling, J1
Beis, I; Gaitanaki, C; Kefaloyianni, E1
Caravatta, L; Cataldi, A; di Giacomo, V; Di Pietro, R; Rana, RA; Sancilio, S1
Lee, YJ; Shukla, SD1
Black, JA; Choi, JS; Dib-Hajj, SD; Hudmon, A; Rush, AM; Tyrrell, L; Waxman, SG1
Graves, PR; Sankala, H; Zeng, Y; Zhang, X1
Brock, TG; Flamand, N; Luo, M; Peters-Golden, M1
Bierings, MB; Bruin, MC; Buitenhuis, M; Coffer, PJ; Geest, CR; Laarhoven, AG; Vellenga, E1
Adachi, S; Kozawa, O; Matsushima-Nishiwaki, R; Moriwaki, H; Natsume, H; Shimizu, M; Shirakami, Y; To, S; Weinstein, IB; Yamauchi, J1
Ballim, RD; Mowla, S; Prince, S; Teng, H1
Cao, X; Chlan-Fourney, J; Edmondson, DE; Jiang, Z; Li, XM; Mousseau, DD; Pennington, PR; Rui, L; Wei, Z1
Kawanishi, M; Koizumi, K; Nishimura, M; Saiki, I; Sakurai, H; Shin, MS; Singhirunnusorn, P; Suzuki, S1
Baek, JH; Kim, HJ; Park, OJ; Ryoo, HM; Woo, KM1
Barhod, E; Hemi, R; Kanety, H; Karasik, A; Kasher-Meron, M; Tirosh, A; Yochananov, Y1
Cidlowski, JA; Galliher-Beckley, AJ; Williams, JG1
Aligue, R; de Olano, N; Gomes, AR; Koo, CY; Lam, EW; Monteiro, LJ; Pinto, PH1
Kasahara, S; Kato, K; Kozawa, O; Matsushima-Nishiwaki, R; Mizuno, T; Sakakibara, S; Tokuda, H1
Lowe-Krentz, LJ; Slee, JB1
Bertucci, L; Blank, VC; Furmento, VA; Marino, VJ; Peña, C; Roguin, LP1
Ishihama, Y; Kawasaki, Y; Saiki, I; Sakuma, T; Sakurai, H; Sugiyama, N; Tanaka, T; Yokoyama, S; Zhou, Y1
Igarashi, K; Itoh, K; Kasai, S; Murayama, K; Richardson, MJE; Shima, H; Sogawa, K; Torii, S; Yasumoto, KI1
Chen, J; Gui, C; Li, H; Li, W; Mao, K; Ren, Y; Wu, X; Yu, H; Zou, F1
Ameen, M; Arthur Ataam, J; Bharucha, N; Bruyneel, AAN; Diecke, S; Feyen, DAM; Furihata, T; Gavidia, AA; Karakikes, I; Kaur, B; Lim, EW; Martinez-Amador, N; Mercola, M; Metallo, CM; Monte, E; Nair, P; Perea-Gil, I; Seeger, T; Serrano, R; Snyder, MP; Termglinchan, V; Vadgama, N1

Other Studies

55 other study(ies) available for sb 203580 and serine

ArticleYear
Participation of a stress-activated protein kinase cascade in the activation of tyrosine hydroxylase in chromaffin cells.
    European journal of biochemistry, 1997, Aug-01, Volume: 247, Issue:3

    Topics: Adrenal Glands; Animals; Arsenites; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Chromaffin Cells; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Rats; Serine; Tyrosine 3-Monooxygenase

1997
The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation.
    Journal of immunology (Baltimore, Md. : 1950), 1999, Apr-15, Volume: 162, Issue:8

    Topics: Adjuvants, Immunologic; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CD18 Antigens; CD8 Antigens; DNA-Binding Proteins; Drug Synergism; Enzyme Activation; Humans; Imidazoles; Interleukin-12; Interleukin-2; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Serine; STAT1 Transcription Factor; STAT3 Transcription Factor; T-Lymphocyte Subsets; Trans-Activators; Tyrosine

1999
The p38MAPK inhibitor SB203580 alleviates ultraviolet-induced phosphorylation at serine 389 but not serine 15 and activation of p53.
    Biochemical and biophysical research communications, 1999, Aug-02, Volume: 261, Issue:2

    Topics: Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Humans; Imidazoles; In Vitro Techniques; Male; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Serine; Testicular Neoplasms; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ultraviolet Rays

1999
Serine phosphorylation and negative regulation of Stat3 by JNK.
    The Journal of biological chemistry, 1999, Oct-22, Volume: 274, Issue:43

    Topics: Amino Acid Substitution; Animals; COS Cells; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Gene Expression Regulation; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphoserine; Point Mutation; Pyridines; Recombinant Fusion Proteins; Serine; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Transfection; Ultraviolet Rays

1999
p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons.
    The EMBO journal, 1999, Oct-15, Volume: 18, Issue:20

    Topics: 3T3 Cells; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Dimerization; DNA Primers; DNA-Binding Proteins; Enzyme Inhibitors; HeLa Cells; Humans; Imidazoles; Interferon Type I; Interferon-gamma; MAP Kinase Kinase 6; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutation; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Protein Structure, Quaternary; Pyridines; Recombinant Proteins; Serine; STAT1 Transcription Factor; Trans-Activators; Transcriptional Activation

1999
Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway.
    Proceedings of the National Academy of Sciences of the United States of America, 1999, Nov-23, Volume: 96, Issue:24

    Topics: Animals; Cell Line; Cell Line, Transformed; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Interferon-gamma; Intracellular Signaling Peptides and Proteins; Janus Kinase 2; Lipopolysaccharides; Macrophages; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyridines; Rabbits; Recombinant Fusion Proteins; Serine; STAT1 Transcription Factor; Trans-Activators; Transcription, Genetic; Tumor Necrosis Factor-alpha; Ultraviolet Rays

1999
Identification of a membrane Ig-induced p38 mitogen-activated protein kinase module that regulates cAMP response element binding protein phosphorylation and transcriptional activation in CH31 B cell lymphomas.
    Journal of immunology (Baltimore, Md. : 1950), 2000, Mar-01, Volume: 164, Issue:5

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Imidazoles; Intracellular Signaling Peptides and Proteins; Lymphoma, B-Cell; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-jun; Pyridines; Receptors, Antigen, B-Cell; RNA, Messenger; Serine; Transcriptional Activation; Tumor Cells, Cultured

2000
Kinetic mechanism of the p38-alpha MAP kinase: phosphoryl transfer to synthetic peptides.
    Biochemistry, 2000, Feb-29, Volume: 39, Issue:8

    Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amino Acid Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Enzyme Inhibitors; Imidazoles; Kinetics; Mitogen-Activated Protein Kinases; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases; Peptides; Phosphorylation; Proline; Protein Binding; Pyridines; Serine; Threonine; Viscosity

2000
Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components.
    The Biochemical journal, 2000, Apr-01, Volume: 347 Pt 1

    Topics: Amino Acid Substitution; Carcinoma, Hepatocellular; Cell Cycle Proteins; DNA-Binding Proteins; Enzyme Inhibitors; Genes, Reporter; Humans; Imidazoles; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-vav; Pyridines; rac GTP-Binding Proteins; Recombinant Proteins; Serine; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Transcriptional Activation; Transfection; Tumor Cells, Cultured

2000
p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils.
    The Journal of biological chemistry, 2001, Feb-02, Volume: 276, Issue:5

    Topics: 3-Phosphoinositide-Dependent Protein Kinases; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Inhibitors; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 3; MAP Kinase Kinase 6; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositols; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Serine; Threonine

2001
p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation.
    The EMBO journal, 2000, Dec-01, Volume: 19, Issue:23

    Topics: Animals; Anisomycin; Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Northern; Cell Nucleus; COS Cells; DNA Damage; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Gamma Rays; Glutathione Transferase; Humans; Hydrogen Peroxide; Imidazoles; Luciferases; Methyl Methanesulfonate; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plant Proteins; Plasmids; Precipitin Tests; Pyridines; Recombinant Fusion Proteins; Serine; Serine Proteinase Inhibitors; Signal Transduction; Threonine; Time Factors; Transfection; Tumor Suppressor Protein p53; Ultraviolet Rays

2000
The stress-induced MAP kinase p38 regulates endocytic trafficking via the GDI:Rab5 complex.
    Molecular cell, 2001, Volume: 7, Issue:2

    Topics: Amino Acid Substitution; Animals; Cell Line; Cytosol; Endocytosis; Endosomes; Enzyme Activation; Fluorescent Antibody Technique; Guanine Nucleotide Dissociation Inhibitors; Humans; Hydrogen Peroxide; Imidazoles; Kinetics; Macromolecular Substances; Membrane Proteins; Mitogen-Activated Protein Kinases; Mutation; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; rab5 GTP-Binding Proteins; Recombinant Fusion Proteins; Serine; Vesicular Transport Proteins

2001
Induction of apoptosis and Fas receptor/Fas ligand expression by ischemia/reperfusion in cardiac myocytes requires serine 727 of the STAT-1 transcription factor but not tyrosine 701.
    The Journal of biological chemistry, 2001, Jul-27, Volume: 276, Issue:30

    Topics: Animals; Animals, Newborn; Apoptosis; Blotting, Western; Cells, Cultured; DNA; DNA-Binding Proteins; Enzyme Inhibitors; Fas Ligand Protein; fas Receptor; Imidazoles; In Situ Nick-End Labeling; Membrane Glycoproteins; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plasmids; Pyridines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Serine; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Transcriptional Activation; Transfection; Tyrosine

2001
Nerve growth factor inhibits apoptosis in memory B lymphocytes via inactivation of p38 MAPK, prevention of Bcl-2 phosphorylation, and cytochrome c release.
    The Journal of biological chemistry, 2001, Oct-19, Volume: 276, Issue:42

    Topics: Animals; Apoptosis; B-Lymphocytes; Cell Nucleus; Cells, Cultured; Cytochrome c Group; Cytosol; DNA Fragmentation; Enzyme Inhibitors; Humans; Imidazoles; Immunologic Memory; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Microscopy, Fluorescence; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nerve Growth Factor; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Precipitin Tests; Protein Binding; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Pyridines; Rats; Recombinant Proteins; Serine; Threonine; Time Factors

2001
Osmotic shock induces G1 arrest through p53 phosphorylation at Ser33 by activated p38MAPK without phosphorylation at Ser15 and Ser20.
    The Journal of biological chemistry, 2001, Oct-19, Volume: 276, Issue:42

    Topics: Acetylation; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Cell Line; Cell Nucleus; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Down-Regulation; E1A-Associated p300 Protein; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; G1 Phase; Genes, Dominant; Genes, p53; Humans; Imidazoles; Luciferases; Lysine; MAP Kinase Kinase 6; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases; Nuclear Proteins; Osmotic Pressure; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Serine; Time Factors; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Suppressor Protein p53

2001
Phosphorylation-dependent cellular localization and thermoprotective role of heat shock protein 25 in hippocampal progenitor cells.
    The Journal of biological chemistry, 2002, May-31, Volume: 277, Issue:22

    Topics: Active Transport, Cell Nucleus; Alanine; Animals; Apoptosis; Aspartic Acid; Blotting, Northern; Blotting, Western; Cell Line; Cell Nucleus; Cytochalasin D; Cytoplasm; DNA Fragmentation; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Heat-Shock Proteins; Hippocampus; Hot Temperature; HSP27 Heat-Shock Proteins; Imidazoles; Immunohistochemistry; Mitogen-Activated Protein Kinases; Models, Genetic; Mutation; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Precipitin Tests; Propidium; Pyridines; Rats; Serine; Signal Transduction; Stem Cells; Temperature; Time Factors; Transfection

2002
The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation.
    The Journal of biological chemistry, 2002, Aug-16, Volume: 277, Issue:33

    Topics: Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Imidazoles; Mitogen-Activated Protein Kinase 14; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Serine; Signal Transduction; Threonine; Transforming Growth Factor beta; Tumor Cells, Cultured; Up-Regulation

2002
Distinct mechanisms of taxol-induced serine phosphorylation of the 66-kDa Shc isoform in A549 and RAW 264.7 cells.
    Biochimica et biophysica acta, 2002, Jun-12, Volume: 1590, Issue:1-3

    Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Antineoplastic Agents, Phytogenic; Butadienes; Cell Line; Enzyme Inhibitors; Gene Expression; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Phosphorylation; Proteins; Pyridines; Serine; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Threonine; Tumor Necrosis Factor-alpha

2002
Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways.
    The Biochemical journal, 2002, Oct-15, Volume: 367, Issue:Pt 2

    Topics: Amino Acid Sequence; Anisomycin; Calcium-Calmodulin-Dependent Protein Kinases; Dose-Response Relationship, Drug; Elongation Factor 2 Kinase; Enzyme Inhibitors; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinase 11; Mitogen-Activated Protein Kinase 13; Mitogen-Activated Protein Kinases; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases; Peptide Elongation Factor 2; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Serine; Signal Transduction; Stress, Physiological; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2002
Human gastrin-releasing peptide receptor mediates sustained CREB phosphorylation and transactivation in HuTu 80 duodenal cancer cells.
    FEBS letters, 2002, Sep-11, Volume: 527, Issue:1-3

    Topics: Bombesin; Calcium; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Duodenal Neoplasms; Enzyme Inhibitors; Humans; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Pyridines; Receptors, Bombesin; Recombinant Fusion Proteins; Serine; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured

2002
Phosphorylation of tyrosine hydroxylase in isolated mice adrenal glands.
    Annals of the New York Academy of Sciences, 2002, Volume: 971

    Topics: Adrenal Glands; Animals; Arsenites; Carrier Proteins; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Imidazoles; Mice; Mice, Inbred C57BL; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Pyridines; Serine; Tyrosine 3-Monooxygenase

2002
The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3.
    The Journal of biological chemistry, 2003, Apr-18, Volume: 278, Issue:16

    Topics: 14-3-3 Proteins; Amino Acid Sequence; Androstadienes; Anisomycin; Binding Sites; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Genes, Dominant; Glutathione Transferase; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Mass Spectrometry; Mitogen-Activated Protein Kinases; Models, Biological; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Recombinant Fusion Proteins; Repressor Proteins; Sequence Homology, Amino Acid; Serine; Time Factors; Tuberous Sclerosis; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins; Tyrosine 3-Monooxygenase; Wortmannin

2003
Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1).
    The EMBO journal, 2003, Mar-17, Volume: 22, Issue:6

    Topics: Animals; Butadienes; Cell Line; Cell Nucleus; Enzyme Inhibitors; Escherichia coli; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Isoquinolines; L Cells; Mice; Mice, Mutant Strains; Mitogen-Activated Protein Kinases; Models, Biological; Mutation; NF-kappa B; Nitriles; Phosphorylation; Protein Subunits; Pyridines; Recombinant Proteins; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Sulfonamides; Transcriptional Activation; Tumor Necrosis Factor-alpha

2003
Reactive oxygen species sensitivity of angiotensin II-dependent translation initiation in vascular smooth muscle cells.
    The Journal of biological chemistry, 2003, Sep-19, Volume: 278, Issue:38

    Topics: Acetylcysteine; Angiotensin II; Animals; Aorta; Azoles; Blotting, Western; Carrier Proteins; Cells, Cultured; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Genes, Dominant; Imidazoles; Intracellular Signaling Peptides and Proteins; Isoindoles; Muscle, Smooth, Vascular; Okadaic Acid; Onium Compounds; Organoselenium Compounds; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Protein Phosphatase 2; Pyridines; Rats; Reactive Oxygen Species; Serine; Threonine; Time Factors

2003
SP600125, an inhibitor of c-jun N-terminal kinase, activates CREB by a p38 MAPK-mediated pathway.
    Biochemical and biophysical research communications, 2003, Aug-08, Volume: 307, Issue:4

    Topics: Animals; Anthracenes; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Pyridines; Serine; Transcriptional Activation

2003
Involvement of tumor suppressor protein p53 and p38 MAPK in caffeic acid phenethyl ester-induced apoptosis of C6 glioma cells.
    Biochemical pharmacology, 2003, Dec-15, Volume: 66, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caffeic Acids; Caspase 3; Caspases; Cytochromes c; Glioma; Imidazoles; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phenylethyl Alcohol; Phosphorylation; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteins; Proto-Oncogene Proteins c-bcl-2; Pyridines; Rats; Serine; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2003
RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1.
    The Journal of biological chemistry, 2004, Mar-26, Volume: 279, Issue:13

    Topics: Adaptor Proteins, Signal Transducing; Animals; CD18 Antigens; Cell Adhesion; Cell Differentiation; Cell Division; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Survival; Cloning, Molecular; COS Cells; Cytoplasm; Cytoskeletal Proteins; Cytoskeleton; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Genes, Reporter; Humans; Imidazoles; Jurkat Cells; Lymphocyte Function-Associated Antigen-1; Mice; Nuclear Proteins; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Pyridines; ran GTP-Binding Protein; Serine; Signal Transduction; Subcellular Fractions; T-Lymphocytes; Tissue Distribution; Transcriptional Activation; Transfection; Two-Hybrid System Techniques

2004
Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis.
    Experimental cell research, 2004, Feb-15, Volume: 293, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Carrier Proteins; Cell Line, Tumor; Cisplatin; Enzyme Inhibitors; Gene Silencing; Humans; Imidazoles; Phosphorylation; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Pyridines; RNA Interference; RNA, Messenger; Serine; Transcriptional Activation; Tumor Suppressor Protein p53

2004
Novel expression of N-cadherin elicits in vitro bladder cell invasion via the Akt signaling pathway.
    Oncogene, 2004, Jun-10, Volume: 23, Issue:27

    Topics: Blotting, Western; Cadherins; Carcinoma; Cell Line, Tumor; Chromones; Clone Cells; Collagen; Drug Combinations; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Immunohistochemistry; Laminin; Morpholines; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proteoglycans; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Pyridines; Serine; Signal Transduction; Transfection; Urinary Bladder Neoplasms

2004
Streptococcus pneumoniae-induced p38 MAPK-dependent phosphorylation of RelA at the interleukin-8 promotor.
    The Journal of biological chemistry, 2004, Dec-17, Volume: 279, Issue:51

    Topics: Animals; Blotting, Western; Bronchi; Cell Nucleus; Cells, Cultured; Chemokines; Chromatin Immunoprecipitation; Cytokines; Dimerization; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Gene Expression Regulation, Enzymologic; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imidazoles; Inflammation; Interleukin-8; Lung; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pneumonia; Promoter Regions, Genetic; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA Polymerase II; RNA, Complementary; Serine; Signal Transduction; Streptococcus pneumoniae; Time Factors; Transcription, Genetic; Transfection

2004
alphaB-crystallin is phosphorylated during myocardial infarction: involvement of platelet-derived growth factor-BB.
    Archives of biochemistry and biophysics, 2005, Jun-15, Volume: 438, Issue:2

    Topics: alpha-Crystallin B Chain; Animals; Becaplermin; Blotting, Western; Disease Models, Animal; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Heart Ventricles; Imidazoles; Immunohistochemistry; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Pyridines; Serine; Time Factors

2005
Inhibition of CREB transcriptional activity in human T lymphocytes by oxidative stress.
    Free radical biology & medicine, 2005, Jun-15, Volume: 38, Issue:12

    Topics: Amino Acid Sequence; CD28 Antigens; CD3 Complex; Cyclic AMP Response Element-Binding Protein; Down-Regulation; Humans; Hydrogen Peroxide; Imidazoles; Indoles; Jurkat Cells; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Antigen, T-Cell; Ribosomal Protein S6 Kinases, 90-kDa; Serine; T-Lymphocytes; Transcription Factors; Transcription, Genetic

2005
Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells.
    Diabetologia, 2005, Volume: 48, Issue:12

    Topics: Animals; Apoptosis; Blotting, Western; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression; Humans; Imidazoles; Insulin; Insulin Secretion; Insulin-Secreting Cells; Interleukin-1; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; NF-kappa B; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Serine; Synaptotagmin I

2005
ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-kappaB transactivation during oxidative stress in skeletal myoblasts.
    Cellular signalling, 2006, Volume: 18, Issue:12

    Topics: Animals; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Enzyme Activation; Flavonoids; Hydrogen Peroxide; I-kappa B Proteins; Imidazoles; Immunoblotting; Isoquinolines; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Myoblasts, Skeletal; NF-kappa B; NF-KappaB Inhibitor alpha; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Ribosomal Protein S6 Kinases, 90-kDa; Serine; src-Family Kinases; Sulfonamides

2006
Cyclic nucleotide response element binding (CREB) protein activation is involved in K562 erythroleukemia cells differentiation.
    Journal of cellular biochemistry, 2007, Mar-01, Volume: 100, Issue:4

    Topics: Apoptosis; Blotting, Western; Cell Differentiation; Cyclic AMP Response Element-Binding Protein; Hemin; Humans; Imidazoles; K562 Cells; Leukemia, Erythroblastic, Acute; Microscopy, Fluorescence; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Serine

2007
Histone H3 phosphorylation at serine 10 and serine 28 is mediated by p38 MAPK in rat hepatocytes exposed to ethanol and acetaldehyde.
    European journal of pharmacology, 2007, Nov-14, Volume: 573, Issue:1-3

    Topics: Acetaldehyde; Animals; Anthracenes; Blotting, Western; Caspase 3; Cell Nucleus; Cells, Cultured; Ethanol; Flavonoids; Hepatocytes; Histones; Imidazoles; Male; Mitogen-Activated Protein Kinase Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Serine

2007
Phosphorylation of sodium channel Na(v)1.8 by p38 mitogen-activated protein kinase increases current density in dorsal root ganglion neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Mar-19, Volume: 28, Issue:12

    Topics: Action Potentials; Animals; Anisomycin; Cells, Cultured; Electric Stimulation; Electroporation; Enzyme Activation; Ganglia, Spinal; Imidazoles; Immunoprecipitation; Male; Models, Biological; NAV1.8 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Neurons; p38 Mitogen-Activated Protein Kinases; Patch-Clamp Techniques; Phosphorylation; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Serine; Sodium Channels

2008
Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies.
    The Biochemical journal, 2008, Aug-01, Volume: 413, Issue:3

    Topics: Amino Acid Sequence; Anthracenes; Argonaute Proteins; Arsenites; Blotting, Western; Cell Line; Eukaryotic Initiation Factor-2; Flavonoids; Glutathione Transferase; Humans; Imidazoles; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Mass Spectrometry; Microscopy, Confocal; Mitogen-Activated Protein Kinase Kinases; Molecular Sequence Data; Mutation; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Sodium Compounds

2008
Phosphorylation of serine 271 on 5-lipoxygenase and its role in nuclear export.
    The Journal of biological chemistry, 2009, Jan-02, Volume: 284, Issue:1

    Topics: Active Transport, Cell Nucleus; Amino Acid Substitution; Animals; Arachidonate 5-Lipoxygenase; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Nucleus; Cricetinae; Dogs; Humans; Imidazoles; Leukotrienes; MAP Kinase Kinase 2; Mice; Mutation, Missense; NIH 3T3 Cells; Nuclear Export Signals; Opossums; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Rabbits; Rats; Serine; Sulfonamides

2009
p38 MAP kinase inhibits neutrophil development through phosphorylation of C/EBPalpha on serine 21.
    Stem cells (Dayton, Ohio), 2009, Volume: 27, Issue:9

    Topics: Animals; Apoptosis; Blotting, Western; CCAAT-Enhancer-Binding Protein-alpha; Cell Differentiation; Cells, Cultured; Enzyme Inhibitors; Eosinophils; Humans; Imidazoles; Immunohistochemistry; MAP Kinase Kinase 3; Mice; Mice, Inbred NOD; Mice, SCID; Myelopoiesis; Neutropenia; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Respiratory Burst; Serine

2009
(-)-Epigallocatechin gallate downregulates EGF receptor via phosphorylation at Ser1046/1047 by p38 MAPK in colon cancer cells.
    Carcinogenesis, 2009, Volume: 30, Issue:9

    Topics: Anticarcinogenic Agents; Catechin; Cell Line, Tumor; Colonic Neoplasms; Down-Regulation; ErbB Receptors; Humans; Imidazoles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-cbl; Pyridines; Serine

2009
Phosphorylation of histone H3 by protein kinase C signaling plays a critical role in the regulation of the developmentally important TBX2 gene.
    The Journal of biological chemistry, 2009, Sep-25, Volume: 284, Issue:39

    Topics: Binding Sites; Blotting, Western; Cell Line; Chromatin Immunoprecipitation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Gene Expression; Histones; Humans; Imidazoles; Indoles; Maleimides; Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Kinase C; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases, 90-kDa; RNA Interference; Serine; Signal Transduction; Sp1 Transcription Factor; T-Box Domain Proteins; Tetradecanoylphorbol Acetate

2009
Serine 209 resides within a putative p38(MAPK) consensus motif and regulates monoamine oxidase-A activity.
    Journal of neurochemistry, 2009, Volume: 111, Issue:1

    Topics: Analysis of Variance; Animals; Benzimidazoles; Calcium; Carbocyanines; Cell Survival; Cells, Cultured; Cerebral Cortex; Clorgyline; Consensus Sequence; Embryo, Mammalian; Enzyme Inhibitors; Female; Humans; Imidazoles; Mice; Mitogen-Activated Protein Kinase 11; Monoamine Oxidase; Neurons; Phosphorylation; Pregnancy; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Serine; Signal Transduction; Transfection

2009
TAK1-mediated serine/threonine phosphorylation of epidermal growth factor receptor via p38/extracellular signal-regulated kinase: NF-{kappa}B-independent survival pathways in tumor necrosis factor alpha signaling.
    Molecular and cellular biology, 2009, Volume: 29, Issue:20

    Topics: Anthracenes; Butadienes; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Imidazoles; Lactones; MAP Kinase Kinase Kinases; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Quinazolines; Resorcinols; RNA, Small Interfering; Serine; Signal Transduction; Threonine; Tumor Necrosis Factor-alpha

2009
FGF2-activated ERK mitogen-activated protein kinase enhances Runx2 acetylation and stabilization.
    The Journal of biological chemistry, 2010, Feb-05, Volume: 285, Issue:6

    Topics: Acetylation; Animals; Butadienes; Cell Line; Core Binding Factor Alpha 1 Subunit; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblast Growth Factor 2; Humans; Imidazoles; Immunoblotting; Immunoprecipitation; Mutation; Nitriles; Phosphorylation; Protein Stability; Pyridines; Serine; Transfection; Ubiquitin; Ubiquitination

2010
p38 mitogen-activated protein kinase-dependent transactivation of ErbB receptor family: a novel common mechanism for stress-induced IRS-1 serine phosphorylation and insulin resistance.
    Diabetes, 2011, Volume: 60, Issue:4

    Topics: Animals; Anisomycin; Cell Line, Tumor; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Hep G2 Cells; Humans; Imidazoles; Immunoblotting; Immunoprecipitation; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Reactive Oxygen Species; Receptor, ErbB-2; Receptor, ErbB-3; Serine; Sphingomyelin Phosphodiesterase; Tumor Necrosis Factors

2011
Ligand-independent phosphorylation of the glucocorticoid receptor integrates cellular stress pathways with nuclear receptor signaling.
    Molecular and cellular biology, 2011, Volume: 31, Issue:23

    Topics: 14-3-3 Proteins; Amino Acid Sequence; Cell Line, Tumor; Dexamethasone; Gene Expression Profiling; Gene Expression Regulation; Glucocorticoids; Humans; Imidazoles; Immunoprecipitation; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation, Missense; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Pyridines; Receptors, Cytoplasmic and Nuclear; Receptors, Glucocorticoid; Serine; Signal Transduction; Stress, Physiological; Transcription, Genetic

2011
The p38 MAPK-MK2 axis regulates E2F1 and FOXM1 expression after epirubicin treatment.
    Molecular cancer research : MCR, 2012, Volume: 10, Issue:9

    Topics: Animals; Anthracenes; Antibiotics, Antineoplastic; Cell Cycle; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; E2F1 Transcription Factor; Enzyme Inhibitors; Epirubicin; Female; Forkhead Box Protein M1; Forkhead Transcription Factors; Gene Knockdown Techniques; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Mice, Knockout; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Serine

2012
Significant correlation between the acceleration of platelet aggregation and phosphorylation of HSP27 at Ser-78 in diabetic patients.
    International journal of molecular medicine, 2012, Volume: 30, Issue:6

    Topics: Adenosine Diphosphate; Aged; Blood Platelets; Case-Control Studies; CD40 Ligand; Diabetes Mellitus, Type 2; Female; Flavonoids; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Imidazoles; Male; Middle Aged; Mitogen-Activated Protein Kinase Kinases; Molecular Chaperones; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Aggregation; Protein Processing, Post-Translational; Pyridines; Serine

2012
Actin realignment and cofilin regulation are essential for barrier integrity during shear stress.
    Journal of cellular biochemistry, 2013, Volume: 114, Issue:4

    Topics: Actins; Animals; Anthracenes; Antigens, CD; beta Catenin; Biomechanical Phenomena; Cadherins; Capillary Permeability; Cattle; Cell Nucleus; Cells, Cultured; Cofilin 1; Cytoplasm; Endothelial Cells; Enzyme Inhibitors; Imidazoles; Intercellular Junctions; Lim Kinases; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Serine; Stress, Mechanical

2013
A chimeric cyclic interferon-α2b peptide induces apoptosis by sequential activation of phosphatidylinositol 3-kinase, protein kinase Cδ and p38 MAP kinase.
    Experimental cell research, 2013, Jun-10, Volume: 319, Issue:10

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Humans; Imidazoles; Interferon alpha-2; Interferon-alpha; p38 Mitogen-Activated Protein Kinases; Peptides, Cyclic; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C-delta; Pyridines; Recombinant Proteins; RNA Interference; RNA, Small Interfering; Serine; Signal Transduction; STAT1 Transcription Factor

2013
p38-Mediated phosphorylation of Eps15 endocytic adaptor protein.
    FEBS letters, 2014, Jan-03, Volume: 588, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Cell Line, Tumor; Chromatography, Liquid; Enzyme Inhibitors; Epidermal Growth Factor; HEK293 Cells; HeLa Cells; Humans; Imidazoles; Immunoblotting; Nanotechnology; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; RNA Interference; Serine; Signal Transduction; Tandem Mass Spectrometry; Tumor Necrosis Factor-alpha

2014
Increase in proapoptotic activity of inhibitory PAS domain protein via phosphorylation by MK2.
    The FEBS journal, 2017, Volume: 284, Issue:23

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Caspase 3; Enzyme Activation; HEK293 Cells; Humans; Imidazoles; Mice; Mitochondria; Mitogen-Activated Protein Kinase 1; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Pyridines; Rats; Repressor Proteins; RNA Interference; Serine; Transcription Factors; Ultraviolet Rays

2017
p38 MAPK-DRP1 signaling is involved in mitochondrial dysfunction and cell death in mutant A53T α-synuclein model of Parkinson's disease.
    Toxicology and applied pharmacology, 2020, 02-01, Volume: 388

    Topics: alpha-Synuclein; Animals; Apoptosis; Cell Line, Tumor; Dynamins; Humans; Imidazoles; MAP Kinase Signaling System; Mice; Mitochondria; Mitochondrial Dynamics; Mutation; Neurons; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; Phosphorylation; Pyridines; Reactive Oxygen Species; Serine

2020
Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy.
    European heart journal, 2022, 09-21, Volume: 43, Issue:36

    Topics: Activating Transcription Factor 4; Adenosine Triphosphate; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Cardiomyopathy, Dilated; Drug Evaluation, Preclinical; Glucose; Glycine; Humans; Imidazoles; Induced Pluripotent Stem Cells; Molecular Targeted Therapy; Mutation; Myocytes, Cardiac; Phosphoglycerate Dehydrogenase; Protein Kinase Inhibitors; Pyridines; Serine; Troponin T

2022