sb 203580 and sb 220025

Topics: Adenosine Triphosphate; Calcium-Calmodulin-Dependent Protein Kinases; Catalytic Domain; Cell Differentiation; Cell Division; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Imidazoles; Kinetin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Models, Chemical; Models, Molecular; p38 Mitogen-Activated Protein Kinases; Protein Conformation; Purines; Pyridines; Pyrimidines; Structure-Activity Relationship

Topics: Enzyme Inhibitors; Mitogen-Activated Protein Kinases; Models, Molecular; p38 Mitogen-Activated Protein Kinases; Phenols; Pyrimidines

Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

Topics: Anti-Inflammatory Agents; Crystallography, X-Ray; Cyclooxygenase 1; Cyclooxygenase 2; Databases, Factual; Drug Design; Drugs, Chinese Herbal; Enzyme Inhibitors; JNK Mitogen-Activated Protein Kinases; Medicine, Chinese Traditional; Models, Chemical; Models, Molecular; Molecular Conformation; p38 Mitogen-Activated Protein Kinases; Phosphodiesterase 4 Inhibitors; Structure-Activity Relationship

Topics: Drug Design; Pharmacogenetics; Protein Kinases; Proteome; Systems Biology

Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase

Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

Topics: Arsenites; Blotting, Western; Calcium Chloride; Cell Division; Cell Line; Cyclin D1; Cysteine Endopeptidases; Down-Regulation; Enzyme Inhibitors; Escherichia coli; Glutathione Transferase; Humans; Hydrogen Peroxide; Imidazoles; Kinetics; Magnesium Chloride; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Osmosis; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Point Mutation; Precipitin Tests; Proteasome Endopeptidase Complex; Pyridines; Pyrimidines; Recombinant Fusion Proteins; RNA Processing, Post-Transcriptional; Sodium Chloride; Threonine; Time Factors; Tumor Cells, Cultured; Ubiquitins

Topics: Animals; Base Sequence; Cloning, Molecular; DNA Primers; Embryonic Development; Enzyme Inhibitors; Female; Fluorescent Antibody Technique, Indirect; Imidazoles; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pregnancy; Pyridines; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction

Topics: Binding Sites; Biosensing Techniques; Buffers; Enzymes, Immobilized; Imidazoles; Kinetics; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Pyrimidines; Substrate Specificity; Surface Plasmon Resonance

Topics: Actins; alpha Catenin; Animals; Blastocyst; Cadherins; Cell Adhesion Molecules; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Embryonic Development; Enzyme Inhibitors; Female; Flavonoids; Fluorescent Antibody Technique, Indirect; Heat-Shock Proteins; Imidazoles; Intracellular Signaling Peptides and Proteins; Mice; Mitogen-Activated Protein Kinase 3; Morula; p38 Mitogen-Activated Protein Kinases; Pregnancy; Protein Serine-Threonine Kinases; Pyridines; Pyrimidines; Signal Transduction; Time Factors

Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Humans; Imidazoles; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Pyrimidines

Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Cells, Cultured; Corticotropin-Releasing Hormone; Epidermal Growth Factor; Female; Gene Expression Regulation, Developmental; Humans; Imidazoles; p38 Mitogen-Activated Protein Kinases; Pregnancy; Pyridines; Pyrimidines; RNA, Messenger; RNA, Small Interfering; Trophoblasts

Topics: Cell Survival; Cells, Cultured; Endothelial Cells; Humans; Imidazoles; Interleukin-1beta; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pulmonary Artery; Pyridines; Pyrimidines; Recombinant Proteins; RNA, Small Interfering; Transcription Factor RelA; Wound Healing