sb 203580 has been researched along with sb 202190 in 95 studies
| Studies (sb 203580) | Trials (sb 203580) | Recent Studies (post-2010) (sb 203580) | Studies (sb 202190) | Trials (sb 202190) | Recent Studies (post-2010) (sb 202190) |
|---|---|---|---|---|---|
| 3,489 | 4 | 1,137 | 651 | 0 | 202 |
| Protein | Taxonomy | sb 203580 (IC50) | sb 202190 (IC50) |
|---|---|---|---|
| Mitogen-activated protein kinase 13 | Homo sapiens (human) | 0.08 | |
| Bromodomain-containing protein 4 | Homo sapiens (human) | 2.95 | |
| Tyrosinase | Mus musculus (house mouse) | 0.03 | |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | 0.08 | |
| Casein kinase I isoform delta | Homo sapiens (human) | 0.188 | |
| Mitogen-activated protein kinase 12 | Homo sapiens (human) | 0.08 | |
| Mitogen-activated protein kinase 11 | Homo sapiens (human) | 0.1038 | |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | 0.0625 | |
| Tau-tubulin kinase 2 | Homo sapiens (human) | 9.34 | |
| large T antigen | Betapolyomavirus macacae | 4.87 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (15.79) | 18.2507 |
| 2000's | 59 (62.11) | 29.6817 |
| 2010's | 21 (22.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caivano, M; Cohen, P; Davies, SP; Reddy, H | 1 |
| Atteridge, CE; Azimioara, MD; Benedetti, MG; Biggs, WH; Carter, TA; Ciceri, P; Edeen, PT; Fabian, MA; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lélias, JM; Lockhart, DJ; Mehta, SA; Milanov, ZV; Patel, HK; Treiber, DK; Velasco, AM; Wodicka, LM; Zarrinkar, PP | 1 |
| Bradley, KA; Damoiseaux, R; Gillespie, EJ; Huang, J; Manchester, M; Rogers, J; Sanchez, AM; Saxe, JP; Thomas, D | 1 |
| Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N | 1 |
| Brumlik, MJ; Burow, ME; Curiel, TJ; Daniel, BJ; Khan, IA; Siekierka, J; Wadsworth, S; Wei, S; Zou, W | 1 |
| Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M | 1 |
| Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Gallant, P; Herrgard, S; Hunt, JP; Karaman, MW; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Treiber, DK; Wodicka, LM; Zarrinkar, PP | 1 |
| Domeyer, DM; Hauser, DR; Kinkel, K; Laufer, SA; Liedtke, AJ | 1 |
| Abadleh, M; Bischof, J; Hauser, D; Hirner, H; Knippschild, U; Laufer, S; Peifer, C; Schattel, V | 1 |
| Hajduk, PJ; Johnson, EF; Kifle, L; Merta, PJ; Metz, JT; Soni, NB | 1 |
| Russu, WA; Shallal, HM | 1 |
| Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A | 1 |
| Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ | 1 |
| Munoz, L | 1 |
| Jung, SH; Manickam, M; Namasivayam, V; Pillaiyar, T | 1 |
| Dart, ML; Hartnett, JR; Jost, E; Killoran, MP; Kirkland, TA; Machleidt, T; Robers, MB; Schwinn, MK; Shi, C; Wilkinson, JM; Wood, KV; Zimmerman, K | 1 |
| Adams, JL; Carr, SA; Doyle, ML; Fisher, S; Gallagher, TF; Huddleston, MJ; Kassis, S; Kumar, S; Lee, JC; Livi, GP; McDonnell, PC; McLaughlin, MM; McNulty, D; Porter, TG; Seibel, G; Young, PR | 1 |
| Gum, RJ; Hand, AT; Kumar, S; Lee, JC; McDonnell, PC; Young, PR | 1 |
| Cohen, P; Craxton, M; Cuenda, A; Goedert, M; Jakes, R | 1 |
| Bemis, GW; Caron, PR; Fitzgibbon, MJ; Galullo, V; Hsiao, K; McCaffrey, PG; Murcko, MA; Pazhanisamy, S; Su, MS; Wilson, KP | 1 |
| Frantz, B; Hermes, JD; LoGrasso, PV; O'Keefe, SJ; O'Neill, EA; Rolando, AM | 1 |
| Borasio, GD; Horstmann, S; Kahle, PJ | 1 |
| Frantz, B; Klatt, T; O'Keefe, SJ; O'Neill, EA; Pang, M; Parsons, J; Rolando, A; Tocci, MJ; Williams, H | 1 |
| Engelman, JA; Lisanti, MP; Scherer, PE | 1 |
| Bröcker, EB; Gillitzer, R; Goebeler, M; Kilian, K; Kunz, M; Ludwig, S; Rapp, UR; Yoshimura, T | 1 |
| Ajizian, SJ; English, BK; Meals, EA | 1 |
| Jain, RG; Pekala, PH; Phelps, KD | 1 |
| Barnes, PJ; De Souza, PM; Giembycz, MA; Kankaanranta, H; Lindsay, MA; Salmon, M | 1 |
| Horiuchi, M; Mita, S; Oki, K; Senda, T; Tsuji, F | 1 |
| Börsch-Haubold, AG; Cohen, P; Gelb, MH; Ghomashchi, F; Goedert, M; Pasquet, S; Watson, SP | 1 |
| Bowden, GT; Chen, W | 1 |
| Horwitz, KB; Lange, CA; Shen, T | 1 |
| Bergers, M; Frenken, M; Pfundt, R; Schalkwijk, J; Wingens, M; Zweers, M | 1 |
| Bokoch, GM; Fish, EN; Lekmine, F; Majchrzak, B; Mayer, I; Platanias, LC; Sharma, N; Uddin, S; Young, PR | 1 |
| Rao, J; Studzinski, GP; Wang, X | 1 |
| Hatanaka, H; Ikeuchi, T; Ishikawa, Y | 1 |
| Kaplan, MH; Zhang, S | 1 |
| Alessi, DR; Cuenda, A | 1 |
| Hanakawa, Y; Hashimoto, K; Ichijo, H; Sawada, Y; Sayama, K; Shirakata, Y; Sun, L; Yamanishi, K; Yamasaki, K | 1 |
| Aihara, Y; Arai, M; Kanai, H; Kanda, T; Kurabayashi, M; Nagai, R; Sekiguchi, K; Tanaka, T; Yokoyama, T | 1 |
| Alsayed, Y; Bokoch, G; Kalvakolanu, DV; Lekmine, F; Mahmud, N; Minucci, S; Platanias, LC; Uddin, S | 1 |
| Blinman, TA; Gukovskaya, AS; Gukovsky, I; Livingston, E; Mouria, M; Pandol, SJ; Zaninovic, V | 1 |
| Alvarez, AM; Benito, M; Porras, A; Roncero, C; Valladares, A; Ventura, JJ | 1 |
| Clarkson, ED; Esplen, JE; Freed, CR; Heidenreich, KA; Marotti, J; Meintzer, MK; Rao, P; Wang, X; Zawada, WM | 1 |
| Aucoin, S; Diaz-Mitoma, F; Gee, K; Kozlowski, M; Kumar, A; Lim, W; Ma, W; Nandan, D | 1 |
| Hershenson, MB; Li, J; Page, K | 1 |
| Fish, EN; Fujita, S; Grumbach, IM; Lekmine, F; Majchrzak, B; Mayer, IA; Platanias, LC; Ravandi, F; Uddin, S; Verma, A | 1 |
| Hayashi, M; Klip, A; Konrad, D; Ramlal, T; Somwar, R; Sweeney, G; Yaworsky, K | 1 |
| Hallsworth, MP; Hirst, SJ; Lai, D; Moir, LM | 1 |
| Asano, Y; Ihn, H; Kubo, M; Tamaki, K; Yamane, K | 1 |
| Bédard, PA; Campos, CB; Linden, R | 1 |
| Curiel, T; Daniel, B; Heidenreich, K; Marches, F; Sonda, S; Wei, S | 1 |
| Becker, D; Brand, P; Knop, J; Plochmann, S; Saloga, J; Valk, E; Zahn, S | 1 |
| Kikuta, K; Masamune, A; Sakai, Y; Satoh, A; Satoh, M; Shimosegawa, T | 1 |
| Dittmer, J; Lindemann, RK; Nordheim, A | 1 |
| Berti, E; Burlando, B; Magnelli, V; Panfoli, I; Viarengo, A | 1 |
| Rao, GN; Yellaturu, CR | 1 |
| Berger, MS; Haas-Kogan, DA; Hirose, Y; Katayama, M; Pieper, RO; Stokoe, D | 1 |
| Ahmed, S; Kikuchi, H; Shibazaki, M; Takeuchi, T | 1 |
| Fernandes, DJ; Harris, T; Ravenhall, CE; Stewart, AG; Tran, T; Vlahos, R | 1 |
| Anter, E; Keaney, JF; Schulz, E; Shapira, OM; Thomas, SR; Vita, JA | 1 |
| Bergé, G; Carnazzi, E; Gagne, D; Galleyrand, JC; Ibarz, G; Martinez, J; Morel, C; Oiry, C | 1 |
| Jungnelius, M; Karlsson, OP; Karlsson, R; Nordin, H | 1 |
| Duarte, CB; Gonçalo, M; Lopes, MC; Matos, TJ | 1 |
| Han, J; Meng, F; Patel, T; Taffetani, S; Yamagiwa, Y | 1 |
| Albrecht, A; Dehner, F; Greim, C; Herweh, Y; Laufer, S; Peifer, C; Thuma, S | 1 |
| Guilbert, LJ; Johnstone, ED; Lowen, B; Sibley, CP | 1 |
| Kok, JJ; Loomans, EE; Nelissen, RL; van der Lee, MM; Zaman, GJ | 1 |
| Boyfield, I; Fonfria, E; Humphrey, PP; Michel, AD; Simon, J; Thompson, KM | 1 |
| Arch, R; Bernstein, M; Brody, SL; Link, D; Mueckler, M; Schuster, DP; Zhou, Z | 1 |
| Clanachan, AS; Dyck, JR; Finegan, BA; Gandhi, M; Jaswal, JS | 1 |
| Hamanoue, M; Sato, K; Takamatsu, K | 1 |
| Bell, JL; Eckert, RE; Jones, SL; Neuder, LE; Trujillo, JC | 1 |
| Lou, L; Quan, H; Xu, Y | 1 |
| Das, KC; Muniyappa, H | 1 |
| Cai, B; Xia, Z | 1 |
| Duschl, A; Eder, K; Fischäder, G; Lehmann, I; Oostingh, GJ; Röder-Stolinski, C | 1 |
| Bartlett, JB; Colston, KW; Dalgleish, AG; Man, HW; Mouratidis, PX; Muller, GW; Stirling, D | 1 |
| Desaki, M; Kato, J; Kikuchi, K; Kohyama, T; Nagase, T; Okazaki, H; Rennard, SI; Takami, K; Takizawa, H; Yamauchi, Y | 1 |
| Bowler, MJ; Shanware, NP; Tibbetts, RS; Williams, LM | 1 |
| Guan, H; Sharma, A; Yang, K | 1 |
| Hara, A; Hayashi, K; Hoshino, T; Ishii, T; Nishimura, B; Oikawa, K; Tabuchi, K; Tanaka, S; Warabi, E; Yanagawa, T | 1 |
| Bellei, B; Flori, E; Larue, L; Maresca, V; Picardo, M; Pitisci, A | 1 |
| Itabe, H; Kato, R; Obama, T; Sakiyama, Y; Suzuki, K; Usui, M; Yamamoto, M | 1 |
| Chang, CF; Chao, YW; Deng, MC; Ho, LT; Hsu, WY; Juan, CC; Kwok, CF; Lien, CC; Tsai, YL | 1 |
| Beachy, DE; Bickford, JS; Herlihy, JD; Newsom, KJ; Nick, HS; Peck, MV; Qiu, X; Walters, JN | 1 |
| Lin, BR; Natarajan, V | 1 |
| Deng, XL; Li, GR; Su, XL; Wang, Y; Zhao, LM | 1 |
| Nemoto, E; Shimauchi, H; Suzuki, R | 1 |
| Dhamija, S; Gaestel, M; Kotlyarov, A; Menon, MB | 1 |
| Al-Lahham, R; Deford, JH; Papaconstantinou, J | 1 |
| Chessel, A; Haillot, E; Jimenez, F; Lepage, T; Molina, MD; Quirin, M | 1 |
| Akagi, D; Ishizawa, M; Makishima, M; Yamamoto, J | 1 |
| Hamanoue, M; Kobayashi, M; Shigiyama, F; Takamatsu, K | 1 |
| Ewendt, F; Föller, M | 1 |
3 review(s) available for sb 203580 and sb 202190
| Article | Year |
|---|---|
Non-kinase targets of protein kinase inhibitors.
Topics: Animals; Drug Design; Drug Evaluation, Preclinical; Humans; Molecular Targeted Therapy; Protein Kinase Inhibitors; Protein Kinases | 2017 |
Inhibitors of Melanogenesis: An Updated Review.
Topics: alpha-MSH; Biphenyl Compounds; Crystallization; Enzyme Inhibitors; Humans; Melanins; Monophenol Monooxygenase; Peptidomimetics; Radiation, Ionizing; Resveratrol; Signal Transduction; Skin | 2018 |
Use of kinase inhibitors to dissect signaling pathways.
Topics: Androstadienes; Animals; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Maleimides; Morpholines; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Sirolimus; Wortmannin | 2000 |
92 other study(ies) available for sb 203580 and sb 202190
| Article | Year |
|---|---|
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides | 2000 |
A small molecule-kinase interaction map for clinical kinase inhibitors.
Topics: Benzamides; Drug Design; Escherichia coli; Escherichia coli Proteins; Imatinib Mesylate; Microchemistry; Pharmaceutical Preparations; Piperazines; Protein Binding; Protein Interaction Mapping; Protein Kinase Inhibitors; Pyrimidines | 2005 |
Amiodarone and bepridil inhibit anthrax toxin entry into host cells.
Topics: Amiodarone; Animals; Anthrax; Antigens, Bacterial; Bacterial Toxins; Bepridil; Cell Line; Cell Survival; Chloroquine; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Macrophages, Peritoneal; Male; Mice; Molecular Structure; Rats; Rats, Inbred F344; Time Factors | 2007 |
The selectivity of protein kinase inhibitors: a further update.
Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera | 2007 |
Drugs designed to inhibit human p38 mitogen-activated protein kinase activation treat Toxoplasma gondii and Encephalitozoon cuniculi infection.
Topics: Animals; Antiprotozoal Agents; CD8 Antigens; Dose-Response Relationship, Drug; Drug Design; Drug Synergism; Drug Therapy, Combination; Encephalitozoon cuniculi; Encephalitozoonosis; Enzyme Inhibitors; Female; Humans; Imidazoles; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; p38 Mitogen-Activated Protein Kinases; Pyridines; Time Factors; Toxoplasma; Toxoplasmosis, Animal | 2007 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2007 |
A quantitative analysis of kinase inhibitor selectivity.
Topics: Binding Sites; Enzyme Activation; Humans; Phosphotransferases; Protein Binding; Protein Interaction Mapping; Protein Kinase Inhibitors; Proteome; Quantitative Structure-Activity Relationship | 2008 |
Design, synthesis, and biological evaluation of novel Tri- and tetrasubstituted imidazoles as highly potent and specific ATP-mimetic inhibitors of p38 MAP kinase: focus on optimized interactions with the enzyme's surface-exposed front region.
Topics: Drug Design; Humans; Imidazoles; Molecular Mimicry; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Structure-Activity Relationship | 2008 |
3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38alpha mitogen activated protein kinase and casein kinase 1delta.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Binding, Competitive; Casein Kinase Idelta; Cell Line; Drug Discovery; Enzyme Inhibitors; Humans; Imidazoles; Inhibitory Concentration 50; Isoxazoles; Mitogen-Activated Protein Kinase 14; Models, Molecular; Molecular Sequence Data; Mutation; Protein Conformation; Rats; Trophoblasts | 2009 |
Navigating the kinome.
Topics: Drug Design; Pharmacogenetics; Protein Kinases; Proteome; Systems Biology | 2011 |
Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Pyrimidines; Stereoisomerism; Structure-Activity Relationship | 2011 |
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase | 2013 |
Identification of potent Yes1 kinase inhibitors using a library screening approach.
Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship | 2013 |
Homogeneous Assay for Target Engagement Utilizing Bioluminescent Thermal Shift.
Topics: | 2018 |
Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site.
Topics: Adenosine; Adenosine Triphosphate; Affinity Labels; Amino Acid Sequence; Binding Sites; Binding, Competitive; Calcium-Calmodulin-Dependent Protein Kinases; Calorimetry; Cloning, Molecular; Cross-Linking Reagents; Enzyme Inhibitors; Escherichia coli; HeLa Cells; Humans; Imidazoles; Kinetics; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; p38 Mitogen-Activated Protein Kinases; Pyridines; Recombinant Proteins; Saccharomyces cerevisiae | 1997 |
Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles.
Topics: Activating Transcription Factor 2; Alternative Splicing; Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cloning, Molecular; DNA Transposable Elements; Enzyme Activation; Enzyme Inhibitors; HeLa Cells; Humans; Imidazoles; Intestine, Small; Kinetics; Male; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Myelin Basic Protein; p38 Mitogen-Activated Protein Kinases; Pancreas; Pyridines; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Testis; Transfection | 1997 |
Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases.
Topics: Amino Acid Sequence; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cloning, Molecular; COS Cells; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Gene Expression Regulation; Humans; Imidazoles; Interleukin-1; MAP Kinase Kinase 4; MAP Kinase Kinase 6; Mitogen-Activated Protein Kinase 12; Mitogen-Activated Protein Kinase 13; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Rats; Sequence Homology, Amino Acid; Substrate Specificity; Tumor Necrosis Factor-alpha; Xenopus | 1997 |
The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase.
Topics: Adenosine Triphosphate; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Drug Design; Enzyme Inhibitors; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Models, Molecular; Molecular Structure; Mutation; p38 Mitogen-Activated Protein Kinases; Protein Binding; Pyridines; Structure-Activity Relationship | 1997 |
Kinetic mechanism for p38 MAP kinase.
Topics: Activating Transcription Factor 2; Adenosine Triphosphate; Calcium-Calmodulin-Dependent Protein Kinases; Cloning, Molecular; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Glutathione Transferase; Humans; Imidazoles; Kinetics; Mitogen-Activated Protein Kinases; Molecular Structure; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Pyridines; Recombinant Fusion Proteins; T-Lymphocytes; Transcription Factors | 1997 |
Inhibitors of p38 mitogen-activated protein kinase promote neuronal survival in vitro.
Topics: Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Cells, Cultured; Chick Embryo; Enzyme Inhibitors; Ganglia, Spinal; Imidazoles; Mitogen-Activated Protein Kinases; Motor Neurons; Nerve Growth Factors; Neurons; Neurons, Afferent; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Protein Kinase Inhibitors; Pyridines; Rats; Ribosomal Protein S6 Kinases, 90-kDa; Stellate Ganglion | 1998 |
The activation state of p38 mitogen-activated protein kinase determines the efficiency of ATP competition for pyridinylimidazole inhibitor binding.
Topics: Adenosine Triphosphate; Binding, Competitive; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Kinetics; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Pyridines; Radioligand Assay; Recombinant Proteins | 1998 |
Specific inhibitors of p38 mitogen-activated protein kinase block 3T3-L1 adipogenesis.
Topics: 3T3 Cells; Adipocytes; Amino Acid Sequence; Animals; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; CCAAT-Enhancer-Binding Proteins; Cell Differentiation; DNA-Binding Proteins; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Pyridines; Sequence Alignment; Transcription Factors | 1998 |
The MKK6/p38 stress kinase cascade is critical for tumor necrosis factor-alpha-induced expression of monocyte-chemoattractant protein-1 in endothelial cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chemokine CCL2; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 6; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Multigene Family; p38 Mitogen-Activated Protein Kinases; Pyridines; Recombinant Fusion Proteins; RNA, Messenger; Signal Transduction; Stress, Physiological; Tumor Necrosis Factor-alpha | 1999 |
Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interf
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dose-Response Relationship, Drug; Flavonoids; Humans; Imidazoles; Interferon-gamma; Lipopolysaccharides; Macrophages; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Pyridines; Tumor Necrosis Factor-alpha | 1999 |
Tumor necrosis factor-alpha initiated signal transduction in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Activating Transcription Factor 1; Adipose Tissue; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Glucose Transporter Type 1; Glucose Transporter Type 4; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Mitogen-Activated Protein Kinase Kinases; Monosaccharide Transport Proteins; Muscle Proteins; NF-kappa B; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Recombinant Fusion Proteins; Signal Transduction; Transcription Factors; Tumor Necrosis Factor-alpha | 1999 |
SB 203580, an inhibitor of p38 mitogen-activated protein kinase, enhances constitutive apoptosis of cytokine-deprived human eosinophils.
Topics: Apoptosis; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Cyclooxygenase Inhibitors; Cytokines; Cytosol; DNA Fragmentation; Enzyme Inhibitors; Eosinophils; Flavonoids; Humans; Imidazoles; In Vitro Techniques; Interleukin-5; Lipoxygenase Inhibitors; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines | 1999 |
Effects of mitogen-activated protein kinase inhibitors or phosphodiesterase inhibitors on interleukin-1-induced cytokines production in synovium-derived cells.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Calcium-Calmodulin-Dependent Protein Kinases; Cytokines; Dose-Response Relationship, Drug; Humans; Imidazoles; Interleukin-1; Phosphodiesterase Inhibitors; Pyridines; Pyrrolidinones; Quinazolines; Rolipram; Synovial Membrane | 1999 |
Phosphorylation of cytosolic phospholipase A2 in platelets is mediated by multiple stress-activated protein kinase pathways.
Topics: Arachidonic Acid; Blood Platelets; Collagen; Cytosol; Enzyme Activation; Enzyme Inhibitors; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 12; Mitogen-Activated Protein Kinase 13; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Platelet Activation; Protein Isoforms; Pyridines; Thrombin | 1999 |
Activation of p38 MAP kinase and ERK are required for ultraviolet-B induced c-fos gene expression in human keratinocytes.
Topics: Cell Line; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genes, fos; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Keratinocytes; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Biosynthesis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-fos; Pyridines; Transcription, Genetic; Ultraviolet Rays | 1999 |
Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome.
Topics: Acetylcysteine; Breast Neoplasms; Consensus Sequence; Cysteine Endopeptidases; Down-Regulation; Enzyme Inhibitors; Female; Glycoproteins; HeLa Cells; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Phosphorylation; Phosphoserine; Promegestone; Proteasome Endopeptidase Complex; Protein Isoforms; Protein Processing, Post-Translational; Pyridines; Receptors, Progesterone; Recombinant Fusion Proteins; Ubiquitins | 2000 |
TNF-alpha and serum induce SKALP/elafin gene expression in human keratinocytes by a p38 MAP kinase-dependent pathway.
Topics: Blotting, Northern; Blotting, Western; Cell Differentiation; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fetal Blood; Gene Expression Regulation; Humans; Imidazoles; Keratinocytes; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Proteinase Inhibitory Proteins, Secretory; Proteins; Pyridines; RNA, Messenger; Tumor Necrosis Factor-alpha | 2000 |
The Rac1/p38 mitogen-activated protein kinase pathway is required for interferon alpha-dependent transcriptional activation but not serine phosphorylation of Stat proteins.
Topics: DNA-Binding Proteins; Enzyme Inhibitors; Humans; Imidazoles; Interferon-alpha; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphoserine; Pyridines; rac1 GTP-Binding Protein; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured | 2000 |
Inhibition of p38 MAP kinase activity up-regulates multiple MAP kinase pathways and potentiates 1,25-dihydroxyvitamin D(3)-induced differentiation of human leukemia HL60 cells.
Topics: Calcitriol; Cell Count; Cell Differentiation; Enzyme Activation; Enzyme Inhibitors; HL-60 Cells; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinases; Monocytes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; S Phase; Time Factors; Up-Regulation | 2000 |
Brain-derived neurotrophic factor accelerates nitric oxide donor-induced apoptosis of cultured cortical neurons.
Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Butadienes; Carbazoles; Cell Nucleus; Cell Survival; Cells, Cultured; Cerebral Cortex; Cycloheximide; Dactinomycin; DNA Fragmentation; Drug Synergism; Embryo, Mammalian; Enzyme Inhibitors; Female; Imidazoles; Immunoglobulin G; Indole Alkaloids; Kinetics; Male; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; Nitric Oxide Donors; Nitriles; Nitroprusside; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Wistar; Receptor, trkB; Signal Transduction | 2000 |
The p38 mitogen-activated protein kinase is required for IL-12-induced IFN-gamma expression.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Interferon-gamma; Interleukin-12; Lymphocyte Activation; MAP Kinase Kinase 3; MAP Kinase Kinase 6; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 10; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Pyridines; Signal Transduction; STAT4 Transcription Factor; T-Lymphocytes; Trans-Activators | 2000 |
Apoptosis signal-regulating kinase 1 (ASK1) is an intracellular inducer of keratinocyte differentiation.
Topics: Cell Differentiation; Cells, Cultured; Enzyme Inhibitors; Genes, Reporter; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Keratinocytes; Kinetics; MAP Kinase Kinase 4; MAP Kinase Kinase Kinase 5; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Transfection | 2001 |
Induction of VEGF gene transcription by IL-1 beta is mediated through stress-activated MAP kinases and Sp1 sites in cardiac myocytes.
Topics: Animals; Animals, Newborn; Cells, Cultured; Dactinomycin; Dinoprost; Endothelial Growth Factors; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Genistein; Heart; Imidazoles; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Lymphokines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Myocardium; Naphthalenes; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Rats; Rats, Wistar; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; RNA, Messenger; Sp1 Transcription Factor; Stress, Physiological; Transcription, Genetic; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to all-trans-retinoic acid.
Topics: Cell Differentiation; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; rac1 GTP-Binding Protein; Tretinoin; Tumor Cells, Cultured | 2001 |
Activation of pancreatic acinar cells on isolation from tissue: cytokine upregulation via p38 MAP kinase.
Topics: Animals; Chemokine CCL2; Chemokine CXCL1; Chemokine CXCL2; Chemokines; Chemokines, CXC; Cytokines; Enzyme Inhibitors; Gene Expression; Imidazoles; In Vitro Techniques; Interleukin-6; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pancreas; Pancreatitis; Pyridines; Rats; RNA, Messenger; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2000 |
p38 mitogen-activated protein kinase mediates tumor necrosis factor-alpha-induced apoptosis in rat fetal brown adipocytes.
Topics: Adipocytes; Adipose Tissue, Brown; Animals; Apoptosis; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-jun; Pyridines; Rats; Tumor Necrosis Factor-alpha | 2000 |
Inhibitors of p38 MAP kinase increase the survival of transplanted dopamine neurons.
Topics: Animals; Brain Tissue Transplantation; Cell Survival; Cells, Cultured; Dopamine; Enzyme Inhibitors; Fetus; Graft Survival; Imidazoles; Male; Mitogen-Activated Protein Kinases; Neurons; p38 Mitogen-Activated Protein Kinases; Parkinsonian Disorders; Pyridines; Rats; Rats, Sprague-Dawley; Recovery of Function | 2001 |
The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide-stimulated human macrophages.
Topics: Arabidopsis Proteins; Base Sequence; Binding Sites; Cell Line; DNA-Binding Proteins; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epstein-Barr Virus Nuclear Antigens; Erythroid-Specific DNA-Binding Factors; Flavonoids; Flow Cytometry; Gene Expression Regulation, Enzymologic; Genes, Reporter; Humans; Imidazoles; Interleukin-10; Lipopolysaccharide Receptors; Lipopolysaccharides; Luciferases; Macrophages; Mitogen-Activated Protein Kinases; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases; Plant Proteins; Plasmids; Polymerase Chain Reaction; Promoter Regions, Genetic; Pyridines; Signal Transduction; Sp1 Transcription Factor; Time Factors; Transcription Factors; Transcription, Genetic; Transfection; Viral Proteins; YY1 Transcription Factor | 2001 |
p38 MAP kinase negatively regulates cyclin D1 expression in airway smooth muscle cells.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cells, Cultured; COS Cells; Cyclin D1; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; MAP Kinase Kinase 3; MAP Kinase Kinase 6; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle, Smooth; Mutation; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Precipitin Tests; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Pyridines; Rats; Recombinant Fusion Proteins; Trachea; Transcription, Genetic; Transfection | 2001 |
The p38 MAPK pathway mediates the growth inhibitory effects of interferon-alpha in BCR-ABL-expressing cells.
Topics: Androstadienes; Cell Division; Cell Line; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Genistein; Humans; Imidazoles; Immunoblotting; Interferon-alpha; Intracellular Signaling Peptides and Proteins; K562 Cells; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Tyrosine; Wortmannin | 2001 |
The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation.
Topics: 3T3 Cells; Androstadienes; Animals; Arabidopsis Proteins; Biological Transport; Deoxyglucose; Enzyme Inhibitors; Glucose; Glucose Transporter Type 4; Hypoglycemic Agents; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Monosaccharide Transport Proteins; Muscle Fibers, Skeletal; Muscle Proteins; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Plant Proteins; Potassium Channels; Pyridines; Thioctic Acid; Wortmannin | 2001 |
Inhibitors of mitogen-activated protein kinases differentially regulate eosinophil-activating cytokine release from human airway smooth muscle.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchi; Butadienes; Cytokines; Drug Evaluation, Preclinical; Eosinophils; Female; Flavonoids; Humans; Imidazoles; Lung Diseases, Obstructive; Male; MAP Kinase Kinase Kinase 1; Middle Aged; Mitogen-Activated Protein Kinases; Muscle, Smooth; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Up-Regulation | 2001 |
IL-4 up-regulates the expression of tissue inhibitor of metalloproteinase-2 in dermal fibroblasts via the p38 mitogen-activated protein kinase dependent pathway.
Topics: Cells, Cultured; Dermis; Enzyme Inhibitors; Fibroblasts; Humans; Imidazoles; Interleukin-4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Mutation; p38 Mitogen-Activated Protein Kinases; Pyridines; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-2; Transcriptional Activation; Up-Regulation | 2002 |
Activation of p38 mitogen-activated protein kinase during normal mitosis in the developing retina.
Topics: Aging; Anaphase; Animals; Animals, Newborn; Cell Cycle; Chromosomes; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Metaphase; Mitogen-Activated Protein Kinases; Mitosis; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Inbred Strains; Rats, Long-Evans; Reference Values; Retina | 2002 |
Pyridinylimidazole p38 mitogen-activated protein kinase inhibitors block intracellular Toxoplasma gondii replication.
Topics: Animals; Butadienes; Cells, Cultured; Cholesterol; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Imidazoles; Inhibitory Concentration 50; Mitogen-Activated Protein Kinases; Mutation; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Toxoplasma | 2002 |
Activation and translocation of p38 mitogen-activated protein kinase after stimulation of monocytes with contact sensitizers.
Topics: Benzalkonium Compounds; Biological Transport; Cytoplasm; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; ets-Domain Protein Elk-1; Haptens; Humans; Imidazoles; In Vitro Techniques; Interleukin-1; Irritants; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Monocytes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins; Pyridines; Transcription Factors | 2002 |
Inhibition of p38 mitogen-activated protein kinase blocks activation of rat pancreatic stellate cells.
Topics: Actins; Androstadienes; Animals; Blotting, Northern; Blotting, Western; Cell Division; Cell Nucleus; Cells, Cultured; Chemokine CCL2; Electrophoresis; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Imidazoles; Interleukin-1; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pancreas; Phosphorylation; Platelet-Derived Growth Factor; Procollagen; Procollagen-Proline Dioxygenase; Protein Serine-Threonine Kinases; Pyridines; Rats; Wortmannin | 2003 |
Interfering with TGFbeta-induced Smad3 nuclear accumulation differentially affects TGFbeta-dependent gene expression.
Topics: Active Transport, Cell Nucleus; Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; DNA-Binding Proteins; Gene Expression Regulation; Humans; Imidazoles; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; RNA, Messenger; Smad3 Protein; Trans-Activators; Transcription, Genetic; Transforming Growth Factor beta | 2003 |
Ligand-independent tyrosine kinase signalling in RTH 149 trout hepatoma cells: comparison among heavy metals and pro-oxidants.
Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Copper; DNA-Binding Proteins; Dose-Response Relationship, Drug; Genistein; Hydrogen Peroxide; Imidazoles; Ligands; Mercury; Metals, Heavy; Milk Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oxidants; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Pyridines; Receptor Protein-Tyrosine Kinases; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 2003 |
A requirement for calcium-independent phospholipase A2 in thrombin-induced arachidonic acid release and growth in vascular smooth muscle cells.
Topics: Animals; Arachidonic Acid; Blotting, Western; Coloring Agents; DNA; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Group VI Phospholipases A2; Imidazoles; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Naphthalenes; Oleic Acid; Oligonucleotides, Antisense; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Pyridines; Pyrones; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetrazolium Salts; Thiazoles; Thrombin; Time Factors | 2003 |
The p38 mitogen-activated protein kinase pathway links the DNA mismatch repair system to the G2 checkpoint and to resistance to chemotherapeutic DNA-methylating agents.
Topics: Antineoplastic Agents, Alkylating; Base Pair Mismatch; Base Sequence; Cell Line, Tumor; Dacarbazine; DNA Methylation; DNA Repair; DNA, Neoplasm; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; G2 Phase; Humans; Imidazoles; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Temozolomide | 2003 |
Suppression by p38 MAP kinase inhibitors (pyridinyl imidazole compounds) of Ah receptor target gene activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin and the possible mechanism.
Topics: Animals; Blotting, Northern; Blotting, Western; Cell Line, Tumor; Chromatin; Cytochrome P-450 CYP1A1; Dioxins; Enzyme Inhibitors; Genes, Reporter; Histones; Humans; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Models, Chemical; p38 Mitogen-Activated Protein Kinases; Plasmids; Precipitin Tests; Pyridines; Receptors, Aryl Hydrocarbon; RNA; RNA, Messenger; Time Factors; Transcription, Genetic; Transfection | 2004 |
Contribution of the p38MAPK signalling pathway to proliferation in human cultured airway smooth muscle cells is mitogen-specific.
Topics: Blotting, Northern; Bronchi; Cell Cycle Proteins; Cell Proliferation; Cells, Cultured; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase Inhibitor p21; Fibroblast Growth Factor 2; Humans; Imidazoles; Mitogens; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Retinoblastoma Protein; RNA, Messenger; Signal Transduction; Thrombin | 2004 |
Activation of endothelial nitric-oxide synthase by the p38 MAPK in response to black tea polyphenols.
Topics: Adenoviridae; Animals; Aorta; Arginine; Blotting, Western; Calcium; Calmodulin; Catalysis; Citrulline; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genetic Vectors; Imidazoles; Immunoprecipitation; Mutation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; p38 Mitogen-Activated Protein Kinases; Phenols; Phosphatidylinositol 3-Kinases; Phosphorylation; Polyphenols; Pyridines; Signal Transduction; Swine; Tea; Time Factors; Transfection | 2004 |
Cross-interactions of two p38 mitogen-activated protein (MAP) kinase inhibitors and two cholecystokinin (CCK) receptor antagonists with the CCK1 receptor and p38 MAP kinase.
Topics: Adenosine Triphosphate; Animals; Benzodiazepinones; Binding Sites; Blotting, Western; COS Cells; Devazepide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genes, Reporter; Hormone Antagonists; Imidazoles; Immunoblotting; Inositol Phosphates; Kinetics; Ligands; MAP Kinase Signaling System; Models, Chemical; Models, Molecular; p38 Mitogen-Activated Protein Kinases; Phenylurea Compounds; Protein Binding; Protein Conformation; Pyridines; Rats; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Signal Transduction; Time Factors; Transfection | 2005 |
Kinetic studies of small molecule interactions with protein kinases using biosensor technology.
Topics: Binding Sites; Biosensing Techniques; Buffers; Enzymes, Immobilized; Imidazoles; Kinetics; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Pyrimidines; Substrate Specificity; Surface Plasmon Resonance | 2005 |
DNFB activates MAPKs and upregulates CD40 in skin-derived dendritic cells.
Topics: Active Transport, Cell Nucleus; Animals; Blotting, Western; CD40 Antigens; Cell Line; Cells, Cultured; Dendritic Cells; Dermatitis, Allergic Contact; Dinitrofluorobenzene; Dose-Response Relationship, Drug; Humans; Imidazoles; Immunohistochemistry; Kinetics; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Phenotype; Phosphorylation; Pyridines; Signal Transduction; Skin; Time Factors; Up-Regulation | 2005 |
IL-6 activates serum and glucocorticoid kinase via p38alpha mitogen-activated protein kinase pathway.
Topics: Cell Line, Tumor; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Humans; Imidazoles; Immediate-Early Proteins; Interleukin-6; Isoenzymes; Mitogen-Activated Protein Kinase 14; Nuclear Proteins; Protein Serine-Threonine Kinases; Pyridines; RNA, Messenger; Signal Transduction | 2005 |
An immunosorbent, nonradioactive p38 MAP kinase assay comparable to standard radioactive liquid-phase assays.
Topics: Activating Transcription Factor 2; Enzyme Inhibitors; Imidazoles; Immunosorbent Techniques; Inhibitory Concentration 50; p38 Mitogen-Activated Protein Kinases; Pyridines; Staurosporine | 2005 |
Epidermal growth factor stimulation of trophoblast differentiation requires MAPK11/14 (p38 MAP kinase) activation.
Topics: Cell Differentiation; Cell Fusion; Cell Proliferation; Cells, Cultured; Chorionic Gonadotropin, beta Subunit, Human; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Female; Humans; Imidazoles; Mitogen-Activated Protein Kinase 11; Mitogen-Activated Protein Kinase 14; Organ Culture Techniques; Placenta; Pregnancy; Pyridines; Trophoblasts | 2005 |
Enzyme fragment complementation binding assay for p38alpha mitogen-activated protein kinase to study the binding kinetics of enzyme inhibitors.
Topics: Animals; Cell Line; Cell Line, Tumor; Dose-Response Relationship, Drug; Green Fluorescent Proteins; Humans; Imidazoles; Kinetics; Mitogen-Activated Protein Kinase 14; Molecular Structure; Naphthalenes; Peptide Fragments; Protein Binding; Protein Kinase Inhibitors; Protein Transport; Pyrazoles; Pyridines; Recombinant Fusion Proteins; Structure-Activity Relationship; Surface Plasmon Resonance | 2006 |
Species and response dependent differences in the effects of MAPK inhibitors on P2X(7) receptor function.
Topics: Adenosine Triphosphate; Animals; Calcium Signaling; Cell Line; Cell Membrane Permeability; Dose-Response Relationship, Drug; Ethidium; Humans; Imidazoles; Indicators and Reagents; Interleukin-1beta; Membrane Potentials; Mice; Mitogen-Activated Protein Kinases; Monocytes; Protein Kinase Inhibitors; Pyridines; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Recombinant Fusion Proteins; Species Specificity; Transfection | 2006 |
Regulation of lipopolysaccharide-induced increases in neutrophil glucose uptake.
Topics: Animals; Glucose; Glucose Transporter Type 1; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Isoquinolines; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Neutrophils; p38 Mitogen-Activated Protein Kinases; Protein Transport; Pyridines | 2007 |
p38 mitogen-activated protein kinase mediates adenosine-induced alterations in myocardial glucose utilization via 5'-AMP-activated protein kinase.
Topics: Adenosine; AMP-Activated Protein Kinases; Animals; Coronary Circulation; Enzyme Inhibitors; Glucose; Glycogen; Imidazoles; Male; Multienzyme Complexes; Myocardial Ischemia; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley | 2007 |
Inhibition of p38 mitogen-activated protein kinase-induced apoptosis in cultured mature oligodendrocytes using SB202190 and SB203580.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Caspases; Cell Differentiation; Cell Line; Cell Survival; Enzyme Inhibitors; Imidazoles; Oligodendroglia; p38 Mitogen-Activated Protein Kinases; Phosphoric Monoester Hydrolases; Pyridines; Rats; Rats, Wistar; Stem Cells | 2007 |
The role of p38 mitogen-activated kinase (MAPK) in the mechanism regulating cyclooxygenase gene expression in equine leukocytes.
Topics: Animals; Cells, Cultured; Cyclooxygenase 2; Enzyme Activation; Epoprostenol; Gene Expression Regulation, Enzymologic; Horses; Imidazoles; Leukocytes; p38 Mitogen-Activated Protein Kinases; Prostaglandins; Pyridines; RNA, Messenger; Time Factors | 2007 |
p38 MAPK, but not ERK1/2, is critically involved in the cytotoxicity of the novel vascular disrupting agent combretastatin A4.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents, Phytogenic; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Fluorescent Antibody Technique; Humans; Imidazoles; Liver Neoplasms; Male; Microtubules; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Pyridines; Stilbenes; Time Factors | 2008 |
Activation of c-Jun N-terminal kinase (JNK) by widely used specific p38 MAPK inhibitors SB202190 and SB203580: a MLK-3-MKK7-dependent mechanism.
Topics: Activating Transcription Factor 2; Cell Line, Tumor; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Enzyme Activators; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 7; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinase Kinase 11; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-jun; Pyridines; RNA Interference; RNA, Small Interfering; Transcription Factor AP-1; Transfection | 2008 |
p38 MAP kinase mediates arsenite-induced apoptosis through FOXO3a activation and induction of Bim transcription.
Topics: Animals; Apoptosis; Arsenites; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Enzyme Activation; Forkhead Box Protein O3; Forkhead Transcription Factors; Imidazoles; JNK Mitogen-Activated Protein Kinases; Models, Biological; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Protein Transport; Pyridines; Rats; RNA Interference; Sodium Compounds; Up-Regulation | 2008 |
Chlorobenzene induces the NF-kappa B and p38 MAP kinase pathways in lung epithelial cells.
Topics: Cell Line; Chemokine CCL2; Chlorobenzenes; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Formazans; Gene Expression; Humans; Imidazoles; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pulmonary Alveoli; Pyridines; Respiratory Mucosa; RNA, Messenger; Tetrazolium Salts; Tumor Necrosis Factor-alpha | 2008 |
Antiproliferative effects of CC-8062 and CC-8075 in pancreatic cancer cells.
Topics: Alitretinoin; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Humans; Imidazoles; p38 Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Tretinoin | 2009 |
C-reactive protein modulates human lung fibroblast migration.
Topics: C-Reactive Protein; Cell Migration Assays; Cell Migration Inhibition; Cells, Cultured; Chemotaxis; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Fibronectins; Humans; Imidazoles; Lipopolysaccharides; Lung; p38 Mitogen-Activated Protein Kinases; Pyridines; Sodium Azide | 2009 |
Non-specific in vivo inhibition of CK1 by the pyridinyl imidazole p38 inhibitors SB 203580 and SB 202190.
Topics: Casein Kinase I; Cell Line; Cyclic AMP Response Element-Binding Protein; Humans; Imidazoles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphoserine; Protein Biosynthesis; Protein Kinase Inhibitors; Pyridines; Stress, Physiological; Substrate Specificity; Suppression, Genetic | 2009 |
The p38 mitogen-activated protein kinase regulates 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) expression in human trophoblast cells through modulation of 11beta-HSD2 messenger ribonucleic acid stability.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Cells, Cultured; Corticotropin-Releasing Hormone; Epidermal Growth Factor; Female; Gene Expression Regulation, Developmental; Humans; Imidazoles; p38 Mitogen-Activated Protein Kinases; Pregnancy; Pyridines; Pyrimidines; RNA, Messenger; RNA, Small Interfering; Trophoblasts | 2009 |
Cochlear protection from acoustic injury by inhibitors of p38 mitogen-activated protein kinase and sequestosome 1 stress protein.
Topics: Acoustic Stimulation; Adaptor Proteins, Signal Transducing; Analysis of Variance; Animals; Cochlea; Cytoprotection; Dose-Response Relationship, Drug; Enzyme Inhibitors; Evoked Potentials, Auditory, Brain Stem; Heat-Shock Proteins; Imidazoles; Mice; Mice, Knockout; p38 Mitogen-Activated Protein Kinases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequestosome-1 Protein | 2010 |
p38 regulates pigmentation via proteasomal degradation of tyrosinase.
Topics: alpha-MSH; Animals; Enzyme Inhibitors; Enzyme Stability; Gene Expression Regulation; Humans; Imidazoles; MAP Kinase Signaling System; Melanins; Melanoma, Experimental; Mice; Microphthalmia-Associated Transcription Factor; Monophenol Monooxygenase; p38 Mitogen-Activated Protein Kinases; Pigmentation; Proteasome Endopeptidase Complex; Pyridines; RNA, Small Interfering; Ubiquitinated Proteins; Ultraviolet Rays | 2010 |
Oxidized low-density lipoprotein increases interleukin-8 production in human gingival epithelial cell line Ca9-22.
Topics: Cell Line, Tumor; Chemokine CCL2; Cholesterol 7-alpha-Hydroxylase; Dextran Sulfate; Dinoprostone; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Fucose; Gingiva; Humans; Imidazoles; Interleukin-1beta; Interleukin-8; Ketocholesterols; Lipoproteins, LDL; Mitogen-Activated Protein Kinases; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Periodontitis; Polysaccharides; Pyridines; Receptors, Scavenger; Sulfuric Acid Esters | 2010 |
Resistin induces monocyte-endothelial cell adhesion by increasing ICAM-1 and VCAM-1 expression in endothelial cells via p38MAPK-dependent pathway.
Topics: Cell Adhesion; Cell Line; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Humans; Imidazoles; Intercellular Adhesion Molecule-1; Monocytes; p38 Mitogen-Activated Protein Kinases; Pyridines; Resistin; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2011 |
cPLA(2)α gene activation by IL-1β is dependent on an upstream kinase pathway, enzymatic activation and downstream 15-lipoxygenase activity: a positive feedback loop.
Topics: Animals; Arachidonate 15-Lipoxygenase; Cell Line; Enzyme Activation; Feedback, Physiological; Fluorenes; Gene Expression; Gene Knockout Techniques; Group IV Phospholipases A2; Humans; Imidazoles; Interleukin-1beta; Isoenzymes; Lipoxygenase Inhibitors; Luteolin; MAP Kinase Kinase 3; MAP Kinase Kinase 6; MAP Kinase Signaling System; Masoprocol; Mice; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Ribosomal Protein S6 Kinases, 90-kDa; Transcriptional Activation | 2011 |
Negative regulation of human U6 snRNA promoter by p38 kinase through Oct-1.
Topics: DNA-Binding Proteins; Down-Regulation; Humans; Imidazoles; Jurkat Cells; Mutation; Octamer Transcription Factor-1; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Pyridines; Regulatory Sequences, Nucleic Acid; RNA, Small Nuclear; Transcription, Genetic; Tumor Cells, Cultured | 2012 |
KCa3.1 channels mediate the increase of cell migration and proliferation by advanced glycation endproducts in cultured rat vascular smooth muscle cells.
Topics: Analysis of Variance; Androstadienes; Animals; Blotting, Western; Butadienes; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Flavonoids; Glycation End Products, Advanced; Imidazoles; Intermediate-Conductance Calcium-Activated Potassium Channels; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; Patch-Clamp Techniques; Pyridines; Rats; RNA Interference; RNA, Small Interfering; Serum Albumin, Bovine; Signal Transduction; Wortmannin | 2013 |
Cyclic tensile force up-regulates BMP-2 expression through MAP kinase and COX-2/PGE2 signaling pathways in human periodontal ligament cells.
Topics: Adult; Bite Force; Bone Morphogenetic Protein 2; Butadienes; Calcification, Physiologic; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Humans; Imidazoles; Male; Mastication; Molar, Third; Nitriles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Stress, Physiological; Sulfonamides; Up-Regulation; Young Adult | 2014 |
The problem of pyridinyl imidazole class inhibitors of MAPK14/p38α and MAPK11/p38β in autophagy research.
Topics: Autophagy; Autophagy-Related Proteins; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; HeLa Cells; HT29 Cells; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Inflammation; Membrane Proteins; Mitogen-Activated Protein Kinase 11; Mitogen-Activated Protein Kinase 14; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Signal Transduction; Vesicular Transport Proteins | 2015 |
Mitochondrial-generated ROS down regulates insulin signaling via activation of the p38MAPK stress response pathway.
Topics: Animals; Cells, Cultured; Hepatocytes; Imidazoles; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; MAP Kinase Signaling System; Mice; Mitochondria; Phosphorylation; Pyridines; Reactive Oxygen Species; Rotenone; Transcriptome | 2016 |
p38 MAPK as an essential regulator of dorsal-ventral axis specification and skeletogenesis during sea urchin development: a re-evaluation.
Topics: Amino Acid Sequence; Animals; Body Patterning; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Imidazoles; MAP Kinase Signaling System; Morphogenesis; Mutation; Nodal Signaling Ligands; p38 Mitogen-Activated Protein Kinases; Paracentrotus; Phenotype; Protein Kinase Inhibitors; Pyridines; Sequence Homology, Amino Acid; Signal Transduction | 2017 |
1α,25-Dihydroxyvitamin D
Topics: Calcium Channels; Cell Cycle Proteins; Cell Line, Tumor; Gene Expression Regulation; Humans; Imidazoles; Intestinal Mucosa; Isoenzymes; Mitogen-Activated Protein Kinase 14; Nuclear Proteins; Protein Kinase Inhibitors; Pyridines; Receptors, Calcitriol; RNA, Small Interfering; Signal Transduction; Transcription, Genetic; TRPV Cation Channels; Vitamin D; Vitamin D3 24-Hydroxylase | 2017 |
Cell-permeable p38 MAP kinase protects adult hippocampal neurons from cell death.
Topics: Animals; Cell Death; Cells, Cultured; Hippocampus; Hypoglycemia; Imidazoles; Mice; Neurons; Neuroprotection; p38 Mitogen-Activated Protein Kinases; Pyridines | 2019 |
p38MAPK controls fibroblast growth factor 23 (FGF23) synthesis in UMR106-osteoblast-like cells and in IDG-SW3 osteocytes.
Topics: Animals; Anisomycin; Cell Line; Enzyme Inhibitors; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Flavanones; Gene Expression Regulation; Imidazoles; Mice; NF-kappa B; Osteoblasts; Osteocytes; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Signal Transduction; Withanolides | 2019 |