Page last updated: 2024-09-05

sb 203580 and sb 202190

sb 203580 has been researched along with sb 202190 in 95 studies

Compound Research Comparison

Studies
(sb 203580)
Trials
(sb 203580)
Recent Studies (post-2010)
(sb 203580)
Studies
(sb 202190)
Trials
(sb 202190)
Recent Studies (post-2010) (sb 202190)
3,48941,1376510202

Protein Interaction Comparison

ProteinTaxonomysb 203580 (IC50)sb 202190 (IC50)
Mitogen-activated protein kinase 13Homo sapiens (human)0.08
Bromodomain-containing protein 4Homo sapiens (human)2.95
TyrosinaseMus musculus (house mouse)0.03
Amine oxidase [flavin-containing] BRattus norvegicus (Norway rat)0.08
Casein kinase I isoform deltaHomo sapiens (human)0.188
Mitogen-activated protein kinase 12Homo sapiens (human)0.08
Mitogen-activated protein kinase 11Homo sapiens (human)0.1038
Mitogen-activated protein kinase 14Homo sapiens (human)0.0625
Tau-tubulin kinase 2Homo sapiens (human)9.34
large T antigenBetapolyomavirus macacae4.87

Research

Studies (95)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's15 (15.79)18.2507
2000's59 (62.11)29.6817
2010's21 (22.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Caivano, M; Cohen, P; Davies, SP; Reddy, H1
Atteridge, CE; Azimioara, MD; Benedetti, MG; Biggs, WH; Carter, TA; Ciceri, P; Edeen, PT; Fabian, MA; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lélias, JM; Lockhart, DJ; Mehta, SA; Milanov, ZV; Patel, HK; Treiber, DK; Velasco, AM; Wodicka, LM; Zarrinkar, PP1
Bradley, KA; Damoiseaux, R; Gillespie, EJ; Huang, J; Manchester, M; Rogers, J; Sanchez, AM; Saxe, JP; Thomas, D1
Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N1
Brumlik, MJ; Burow, ME; Curiel, TJ; Daniel, BJ; Khan, IA; Siekierka, J; Wadsworth, S; Wei, S; Zou, W1
Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M1
Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Gallant, P; Herrgard, S; Hunt, JP; Karaman, MW; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Treiber, DK; Wodicka, LM; Zarrinkar, PP1
Domeyer, DM; Hauser, DR; Kinkel, K; Laufer, SA; Liedtke, AJ1
Abadleh, M; Bischof, J; Hauser, D; Hirner, H; Knippschild, U; Laufer, S; Peifer, C; Schattel, V1
Hajduk, PJ; Johnson, EF; Kifle, L; Merta, PJ; Metz, JT; Soni, NB1
Russu, WA; Shallal, HM1
Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Munoz, L1
Jung, SH; Manickam, M; Namasivayam, V; Pillaiyar, T1
Dart, ML; Hartnett, JR; Jost, E; Killoran, MP; Kirkland, TA; Machleidt, T; Robers, MB; Schwinn, MK; Shi, C; Wilkinson, JM; Wood, KV; Zimmerman, K1
Adams, JL; Carr, SA; Doyle, ML; Fisher, S; Gallagher, TF; Huddleston, MJ; Kassis, S; Kumar, S; Lee, JC; Livi, GP; McDonnell, PC; McLaughlin, MM; McNulty, D; Porter, TG; Seibel, G; Young, PR1
Gum, RJ; Hand, AT; Kumar, S; Lee, JC; McDonnell, PC; Young, PR1
Cohen, P; Craxton, M; Cuenda, A; Goedert, M; Jakes, R1
Bemis, GW; Caron, PR; Fitzgibbon, MJ; Galullo, V; Hsiao, K; McCaffrey, PG; Murcko, MA; Pazhanisamy, S; Su, MS; Wilson, KP1
Frantz, B; Hermes, JD; LoGrasso, PV; O'Keefe, SJ; O'Neill, EA; Rolando, AM1
Borasio, GD; Horstmann, S; Kahle, PJ1
Frantz, B; Klatt, T; O'Keefe, SJ; O'Neill, EA; Pang, M; Parsons, J; Rolando, A; Tocci, MJ; Williams, H1
Engelman, JA; Lisanti, MP; Scherer, PE1
Bröcker, EB; Gillitzer, R; Goebeler, M; Kilian, K; Kunz, M; Ludwig, S; Rapp, UR; Yoshimura, T1
Ajizian, SJ; English, BK; Meals, EA1
Jain, RG; Pekala, PH; Phelps, KD1
Barnes, PJ; De Souza, PM; Giembycz, MA; Kankaanranta, H; Lindsay, MA; Salmon, M1
Horiuchi, M; Mita, S; Oki, K; Senda, T; Tsuji, F1
Börsch-Haubold, AG; Cohen, P; Gelb, MH; Ghomashchi, F; Goedert, M; Pasquet, S; Watson, SP1
Bowden, GT; Chen, W1
Horwitz, KB; Lange, CA; Shen, T1
Bergers, M; Frenken, M; Pfundt, R; Schalkwijk, J; Wingens, M; Zweers, M1
Bokoch, GM; Fish, EN; Lekmine, F; Majchrzak, B; Mayer, I; Platanias, LC; Sharma, N; Uddin, S; Young, PR1
Rao, J; Studzinski, GP; Wang, X1
Hatanaka, H; Ikeuchi, T; Ishikawa, Y1
Kaplan, MH; Zhang, S1
Alessi, DR; Cuenda, A1
Hanakawa, Y; Hashimoto, K; Ichijo, H; Sawada, Y; Sayama, K; Shirakata, Y; Sun, L; Yamanishi, K; Yamasaki, K1
Aihara, Y; Arai, M; Kanai, H; Kanda, T; Kurabayashi, M; Nagai, R; Sekiguchi, K; Tanaka, T; Yokoyama, T1
Alsayed, Y; Bokoch, G; Kalvakolanu, DV; Lekmine, F; Mahmud, N; Minucci, S; Platanias, LC; Uddin, S1
Blinman, TA; Gukovskaya, AS; Gukovsky, I; Livingston, E; Mouria, M; Pandol, SJ; Zaninovic, V1
Alvarez, AM; Benito, M; Porras, A; Roncero, C; Valladares, A; Ventura, JJ1
Clarkson, ED; Esplen, JE; Freed, CR; Heidenreich, KA; Marotti, J; Meintzer, MK; Rao, P; Wang, X; Zawada, WM1
Aucoin, S; Diaz-Mitoma, F; Gee, K; Kozlowski, M; Kumar, A; Lim, W; Ma, W; Nandan, D1
Hershenson, MB; Li, J; Page, K1
Fish, EN; Fujita, S; Grumbach, IM; Lekmine, F; Majchrzak, B; Mayer, IA; Platanias, LC; Ravandi, F; Uddin, S; Verma, A1
Hayashi, M; Klip, A; Konrad, D; Ramlal, T; Somwar, R; Sweeney, G; Yaworsky, K1
Hallsworth, MP; Hirst, SJ; Lai, D; Moir, LM1
Asano, Y; Ihn, H; Kubo, M; Tamaki, K; Yamane, K1
Bédard, PA; Campos, CB; Linden, R1
Curiel, T; Daniel, B; Heidenreich, K; Marches, F; Sonda, S; Wei, S1
Becker, D; Brand, P; Knop, J; Plochmann, S; Saloga, J; Valk, E; Zahn, S1
Kikuta, K; Masamune, A; Sakai, Y; Satoh, A; Satoh, M; Shimosegawa, T1
Dittmer, J; Lindemann, RK; Nordheim, A1
Berti, E; Burlando, B; Magnelli, V; Panfoli, I; Viarengo, A1
Rao, GN; Yellaturu, CR1
Berger, MS; Haas-Kogan, DA; Hirose, Y; Katayama, M; Pieper, RO; Stokoe, D1
Ahmed, S; Kikuchi, H; Shibazaki, M; Takeuchi, T1
Fernandes, DJ; Harris, T; Ravenhall, CE; Stewart, AG; Tran, T; Vlahos, R1
Anter, E; Keaney, JF; Schulz, E; Shapira, OM; Thomas, SR; Vita, JA1
Bergé, G; Carnazzi, E; Gagne, D; Galleyrand, JC; Ibarz, G; Martinez, J; Morel, C; Oiry, C1
Jungnelius, M; Karlsson, OP; Karlsson, R; Nordin, H1
Duarte, CB; Gonçalo, M; Lopes, MC; Matos, TJ1
Han, J; Meng, F; Patel, T; Taffetani, S; Yamagiwa, Y1
Albrecht, A; Dehner, F; Greim, C; Herweh, Y; Laufer, S; Peifer, C; Thuma, S1
Guilbert, LJ; Johnstone, ED; Lowen, B; Sibley, CP1
Kok, JJ; Loomans, EE; Nelissen, RL; van der Lee, MM; Zaman, GJ1
Boyfield, I; Fonfria, E; Humphrey, PP; Michel, AD; Simon, J; Thompson, KM1
Arch, R; Bernstein, M; Brody, SL; Link, D; Mueckler, M; Schuster, DP; Zhou, Z1
Clanachan, AS; Dyck, JR; Finegan, BA; Gandhi, M; Jaswal, JS1
Hamanoue, M; Sato, K; Takamatsu, K1
Bell, JL; Eckert, RE; Jones, SL; Neuder, LE; Trujillo, JC1
Lou, L; Quan, H; Xu, Y1
Das, KC; Muniyappa, H1
Cai, B; Xia, Z1
Duschl, A; Eder, K; Fischäder, G; Lehmann, I; Oostingh, GJ; Röder-Stolinski, C1
Bartlett, JB; Colston, KW; Dalgleish, AG; Man, HW; Mouratidis, PX; Muller, GW; Stirling, D1
Desaki, M; Kato, J; Kikuchi, K; Kohyama, T; Nagase, T; Okazaki, H; Rennard, SI; Takami, K; Takizawa, H; Yamauchi, Y1
Bowler, MJ; Shanware, NP; Tibbetts, RS; Williams, LM1
Guan, H; Sharma, A; Yang, K1
Hara, A; Hayashi, K; Hoshino, T; Ishii, T; Nishimura, B; Oikawa, K; Tabuchi, K; Tanaka, S; Warabi, E; Yanagawa, T1
Bellei, B; Flori, E; Larue, L; Maresca, V; Picardo, M; Pitisci, A1
Itabe, H; Kato, R; Obama, T; Sakiyama, Y; Suzuki, K; Usui, M; Yamamoto, M1
Chang, CF; Chao, YW; Deng, MC; Ho, LT; Hsu, WY; Juan, CC; Kwok, CF; Lien, CC; Tsai, YL1
Beachy, DE; Bickford, JS; Herlihy, JD; Newsom, KJ; Nick, HS; Peck, MV; Qiu, X; Walters, JN1
Lin, BR; Natarajan, V1
Deng, XL; Li, GR; Su, XL; Wang, Y; Zhao, LM1
Nemoto, E; Shimauchi, H; Suzuki, R1
Dhamija, S; Gaestel, M; Kotlyarov, A; Menon, MB1
Al-Lahham, R; Deford, JH; Papaconstantinou, J1
Chessel, A; Haillot, E; Jimenez, F; Lepage, T; Molina, MD; Quirin, M1
Akagi, D; Ishizawa, M; Makishima, M; Yamamoto, J1
Hamanoue, M; Kobayashi, M; Shigiyama, F; Takamatsu, K1
Ewendt, F; Föller, M1

Reviews

3 review(s) available for sb 203580 and sb 202190

ArticleYear
Non-kinase targets of protein kinase inhibitors.
    Nature reviews. Drug discovery, 2017, Volume: 16, Issue:6

    Topics: Animals; Drug Design; Drug Evaluation, Preclinical; Humans; Molecular Targeted Therapy; Protein Kinase Inhibitors; Protein Kinases

2017
Inhibitors of Melanogenesis: An Updated Review.
    Journal of medicinal chemistry, 2018, 09-13, Volume: 61, Issue:17

    Topics: alpha-MSH; Biphenyl Compounds; Crystallization; Enzyme Inhibitors; Humans; Melanins; Monophenol Monooxygenase; Peptidomimetics; Radiation, Ionizing; Resveratrol; Signal Transduction; Skin

2018
Use of kinase inhibitors to dissect signaling pathways.
    Methods in molecular biology (Clifton, N.J.), 2000, Volume: 99

    Topics: Androstadienes; Animals; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Maleimides; Morpholines; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Sirolimus; Wortmannin

2000

Other Studies

92 other study(ies) available for sb 203580 and sb 202190

ArticleYear
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
    The Biochemical journal, 2000, Oct-01, Volume: 351, Issue:Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides

2000
A small molecule-kinase interaction map for clinical kinase inhibitors.
    Nature biotechnology, 2005, Volume: 23, Issue:3

    Topics: Benzamides; Drug Design; Escherichia coli; Escherichia coli Proteins; Imatinib Mesylate; Microchemistry; Pharmaceutical Preparations; Piperazines; Protein Binding; Protein Interaction Mapping; Protein Kinase Inhibitors; Pyrimidines

2005
Amiodarone and bepridil inhibit anthrax toxin entry into host cells.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:7

    Topics: Amiodarone; Animals; Anthrax; Antigens, Bacterial; Bacterial Toxins; Bepridil; Cell Line; Cell Survival; Chloroquine; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Macrophages, Peritoneal; Male; Mice; Molecular Structure; Rats; Rats, Inbred F344; Time Factors

2007
The selectivity of protein kinase inhibitors: a further update.
    The Biochemical journal, 2007, Dec-15, Volume: 408, Issue:3

    Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera

2007
Drugs designed to inhibit human p38 mitogen-activated protein kinase activation treat Toxoplasma gondii and Encephalitozoon cuniculi infection.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:12

    Topics: Animals; Antiprotozoal Agents; CD8 Antigens; Dose-Response Relationship, Drug; Drug Design; Drug Synergism; Drug Therapy, Combination; Encephalitozoon cuniculi; Encephalitozoonosis; Enzyme Inhibitors; Female; Humans; Imidazoles; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; p38 Mitogen-Activated Protein Kinases; Pyridines; Time Factors; Toxoplasma; Toxoplasmosis, Animal

2007
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-18, Volume: 104, Issue:51

    Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

2007
A quantitative analysis of kinase inhibitor selectivity.
    Nature biotechnology, 2008, Volume: 26, Issue:1

    Topics: Binding Sites; Enzyme Activation; Humans; Phosphotransferases; Protein Binding; Protein Interaction Mapping; Protein Kinase Inhibitors; Proteome; Quantitative Structure-Activity Relationship

2008
Design, synthesis, and biological evaluation of novel Tri- and tetrasubstituted imidazoles as highly potent and specific ATP-mimetic inhibitors of p38 MAP kinase: focus on optimized interactions with the enzyme's surface-exposed front region.
    Journal of medicinal chemistry, 2008, Jul-24, Volume: 51, Issue:14

    Topics: Drug Design; Humans; Imidazoles; Molecular Mimicry; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Structure-Activity Relationship

2008
3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38alpha mitogen activated protein kinase and casein kinase 1delta.
    Journal of medicinal chemistry, 2009, Dec-10, Volume: 52, Issue:23

    Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Binding, Competitive; Casein Kinase Idelta; Cell Line; Drug Discovery; Enzyme Inhibitors; Humans; Imidazoles; Inhibitory Concentration 50; Isoxazoles; Mitogen-Activated Protein Kinase 14; Models, Molecular; Molecular Sequence Data; Mutation; Protein Conformation; Rats; Trophoblasts

2009
Navigating the kinome.
    Nature chemical biology, 2011, Volume: 7, Issue:4

    Topics: Drug Design; Pharmacogenetics; Protein Kinases; Proteome; Systems Biology

2011
Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:6

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Pyrimidines; Stereoisomerism; Structure-Activity Relationship

2011
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
    The Biochemical journal, 2013, Apr-15, Volume: 451, Issue:2

    Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase

2013
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
Homogeneous Assay for Target Engagement Utilizing Bioluminescent Thermal Shift.
    ACS medicinal chemistry letters, 2018, Jun-14, Volume: 9, Issue:6

    Topics:

2018
Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site.
    The Journal of biological chemistry, 1997, May-02, Volume: 272, Issue:18

    Topics: Adenosine; Adenosine Triphosphate; Affinity Labels; Amino Acid Sequence; Binding Sites; Binding, Competitive; Calcium-Calmodulin-Dependent Protein Kinases; Calorimetry; Cloning, Molecular; Cross-Linking Reagents; Enzyme Inhibitors; Escherichia coli; HeLa Cells; Humans; Imidazoles; Kinetics; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; p38 Mitogen-Activated Protein Kinases; Pyridines; Recombinant Proteins; Saccharomyces cerevisiae

1997
Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles.
    Biochemical and biophysical research communications, 1997, Jun-27, Volume: 235, Issue:3

    Topics: Activating Transcription Factor 2; Alternative Splicing; Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cloning, Molecular; DNA Transposable Elements; Enzyme Activation; Enzyme Inhibitors; HeLa Cells; Humans; Imidazoles; Intestine, Small; Kinetics; Male; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Myelin Basic Protein; p38 Mitogen-Activated Protein Kinases; Pancreas; Pyridines; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Testis; Transfection

1997
Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases.
    The EMBO journal, 1997, Jun-16, Volume: 16, Issue:12

    Topics: Amino Acid Sequence; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cloning, Molecular; COS Cells; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Gene Expression Regulation; Humans; Imidazoles; Interleukin-1; MAP Kinase Kinase 4; MAP Kinase Kinase 6; Mitogen-Activated Protein Kinase 12; Mitogen-Activated Protein Kinase 13; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Rats; Sequence Homology, Amino Acid; Substrate Specificity; Tumor Necrosis Factor-alpha; Xenopus

1997
The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase.
    Chemistry & biology, 1997, Volume: 4, Issue:6

    Topics: Adenosine Triphosphate; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Drug Design; Enzyme Inhibitors; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Models, Molecular; Molecular Structure; Mutation; p38 Mitogen-Activated Protein Kinases; Protein Binding; Pyridines; Structure-Activity Relationship

1997
Kinetic mechanism for p38 MAP kinase.
    Biochemistry, 1997, Aug-26, Volume: 36, Issue:34

    Topics: Activating Transcription Factor 2; Adenosine Triphosphate; Calcium-Calmodulin-Dependent Protein Kinases; Cloning, Molecular; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Glutathione Transferase; Humans; Imidazoles; Kinetics; Mitogen-Activated Protein Kinases; Molecular Structure; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Pyridines; Recombinant Fusion Proteins; T-Lymphocytes; Transcription Factors

1997
Inhibitors of p38 mitogen-activated protein kinase promote neuronal survival in vitro.
    Journal of neuroscience research, 1998, May-15, Volume: 52, Issue:4

    Topics: Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Cells, Cultured; Chick Embryo; Enzyme Inhibitors; Ganglia, Spinal; Imidazoles; Mitogen-Activated Protein Kinases; Motor Neurons; Nerve Growth Factors; Neurons; Neurons, Afferent; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Protein Kinase Inhibitors; Pyridines; Rats; Ribosomal Protein S6 Kinases, 90-kDa; Stellate Ganglion

1998
The activation state of p38 mitogen-activated protein kinase determines the efficiency of ATP competition for pyridinylimidazole inhibitor binding.
    Biochemistry, 1998, Sep-29, Volume: 37, Issue:39

    Topics: Adenosine Triphosphate; Binding, Competitive; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Kinetics; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Pyridines; Radioligand Assay; Recombinant Proteins

1998
Specific inhibitors of p38 mitogen-activated protein kinase block 3T3-L1 adipogenesis.
    The Journal of biological chemistry, 1998, Nov-27, Volume: 273, Issue:48

    Topics: 3T3 Cells; Adipocytes; Amino Acid Sequence; Animals; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; CCAAT-Enhancer-Binding Proteins; Cell Differentiation; DNA-Binding Proteins; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Pyridines; Sequence Alignment; Transcription Factors

1998
The MKK6/p38 stress kinase cascade is critical for tumor necrosis factor-alpha-induced expression of monocyte-chemoattractant protein-1 in endothelial cells.
    Blood, 1999, Feb-01, Volume: 93, Issue:3

    Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chemokine CCL2; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 6; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Multigene Family; p38 Mitogen-Activated Protein Kinases; Pyridines; Recombinant Fusion Proteins; RNA, Messenger; Signal Transduction; Stress, Physiological; Tumor Necrosis Factor-alpha

1999
Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interf
    The Journal of infectious diseases, 1999, Volume: 179, Issue:4

    Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dose-Response Relationship, Drug; Flavonoids; Humans; Imidazoles; Interferon-gamma; Lipopolysaccharides; Macrophages; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Pyridines; Tumor Necrosis Factor-alpha

1999
Tumor necrosis factor-alpha initiated signal transduction in 3T3-L1 adipocytes.
    Journal of cellular physiology, 1999, Volume: 179, Issue:1

    Topics: 3T3 Cells; Activating Transcription Factor 1; Adipose Tissue; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Glucose Transporter Type 1; Glucose Transporter Type 4; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Mitogen-Activated Protein Kinase Kinases; Monosaccharide Transport Proteins; Muscle Proteins; NF-kappa B; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Recombinant Fusion Proteins; Signal Transduction; Transcription Factors; Tumor Necrosis Factor-alpha

1999
SB 203580, an inhibitor of p38 mitogen-activated protein kinase, enhances constitutive apoptosis of cytokine-deprived human eosinophils.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:2

    Topics: Apoptosis; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cell Survival; Cyclooxygenase Inhibitors; Cytokines; Cytosol; DNA Fragmentation; Enzyme Inhibitors; Eosinophils; Flavonoids; Humans; Imidazoles; In Vitro Techniques; Interleukin-5; Lipoxygenase Inhibitors; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines

1999
Effects of mitogen-activated protein kinase inhibitors or phosphodiesterase inhibitors on interleukin-1-induced cytokines production in synovium-derived cells.
    Immunology letters, 1999, Jun-01, Volume: 68, Issue:2-3

    Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Calcium-Calmodulin-Dependent Protein Kinases; Cytokines; Dose-Response Relationship, Drug; Humans; Imidazoles; Interleukin-1; Phosphodiesterase Inhibitors; Pyridines; Pyrrolidinones; Quinazolines; Rolipram; Synovial Membrane

1999
Phosphorylation of cytosolic phospholipase A2 in platelets is mediated by multiple stress-activated protein kinase pathways.
    European journal of biochemistry, 1999, Oct-01, Volume: 265, Issue:1

    Topics: Arachidonic Acid; Blood Platelets; Collagen; Cytosol; Enzyme Activation; Enzyme Inhibitors; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 12; Mitogen-Activated Protein Kinase 13; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Platelet Activation; Protein Isoforms; Pyridines; Thrombin

1999
Activation of p38 MAP kinase and ERK are required for ultraviolet-B induced c-fos gene expression in human keratinocytes.
    Oncogene, 1999, Dec-09, Volume: 18, Issue:52

    Topics: Cell Line; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genes, fos; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Keratinocytes; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Biosynthesis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-fos; Pyridines; Transcription, Genetic; Ultraviolet Rays

1999
Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, Feb-01, Volume: 97, Issue:3

    Topics: Acetylcysteine; Breast Neoplasms; Consensus Sequence; Cysteine Endopeptidases; Down-Regulation; Enzyme Inhibitors; Female; Glycoproteins; HeLa Cells; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Phosphorylation; Phosphoserine; Promegestone; Proteasome Endopeptidase Complex; Protein Isoforms; Protein Processing, Post-Translational; Pyridines; Receptors, Progesterone; Recombinant Fusion Proteins; Ubiquitins

2000
TNF-alpha and serum induce SKALP/elafin gene expression in human keratinocytes by a p38 MAP kinase-dependent pathway.
    Archives of dermatological research, 2000, Volume: 292, Issue:4

    Topics: Blotting, Northern; Blotting, Western; Cell Differentiation; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fetal Blood; Gene Expression Regulation; Humans; Imidazoles; Keratinocytes; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Proteinase Inhibitory Proteins, Secretory; Proteins; Pyridines; RNA, Messenger; Tumor Necrosis Factor-alpha

2000
The Rac1/p38 mitogen-activated protein kinase pathway is required for interferon alpha-dependent transcriptional activation but not serine phosphorylation of Stat proteins.
    The Journal of biological chemistry, 2000, Sep-08, Volume: 275, Issue:36

    Topics: DNA-Binding Proteins; Enzyme Inhibitors; Humans; Imidazoles; Interferon-alpha; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphoserine; Pyridines; rac1 GTP-Binding Protein; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured

2000
Inhibition of p38 MAP kinase activity up-regulates multiple MAP kinase pathways and potentiates 1,25-dihydroxyvitamin D(3)-induced differentiation of human leukemia HL60 cells.
    Experimental cell research, 2000, Aug-01, Volume: 258, Issue:2

    Topics: Calcitriol; Cell Count; Cell Differentiation; Enzyme Activation; Enzyme Inhibitors; HL-60 Cells; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinases; Monocytes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; S Phase; Time Factors; Up-Regulation

2000
Brain-derived neurotrophic factor accelerates nitric oxide donor-induced apoptosis of cultured cortical neurons.
    Journal of neurochemistry, 2000, Volume: 75, Issue:2

    Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Butadienes; Carbazoles; Cell Nucleus; Cell Survival; Cells, Cultured; Cerebral Cortex; Cycloheximide; Dactinomycin; DNA Fragmentation; Drug Synergism; Embryo, Mammalian; Enzyme Inhibitors; Female; Imidazoles; Immunoglobulin G; Indole Alkaloids; Kinetics; Male; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; Nitric Oxide Donors; Nitriles; Nitroprusside; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Wistar; Receptor, trkB; Signal Transduction

2000
The p38 mitogen-activated protein kinase is required for IL-12-induced IFN-gamma expression.
    Journal of immunology (Baltimore, Md. : 1950), 2000, Aug-01, Volume: 165, Issue:3

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Interferon-gamma; Interleukin-12; Lymphocyte Activation; MAP Kinase Kinase 3; MAP Kinase Kinase 6; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 10; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Pyridines; Signal Transduction; STAT4 Transcription Factor; T-Lymphocytes; Trans-Activators

2000
Apoptosis signal-regulating kinase 1 (ASK1) is an intracellular inducer of keratinocyte differentiation.
    The Journal of biological chemistry, 2001, Jan-12, Volume: 276, Issue:2

    Topics: Cell Differentiation; Cells, Cultured; Enzyme Inhibitors; Genes, Reporter; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Keratinocytes; Kinetics; MAP Kinase Kinase 4; MAP Kinase Kinase Kinase 5; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Transfection

2001
Induction of VEGF gene transcription by IL-1 beta is mediated through stress-activated MAP kinases and Sp1 sites in cardiac myocytes.
    Journal of molecular and cellular cardiology, 2000, Volume: 32, Issue:11

    Topics: Animals; Animals, Newborn; Cells, Cultured; Dactinomycin; Dinoprost; Endothelial Growth Factors; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Genistein; Heart; Imidazoles; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Lymphokines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Myocardium; Naphthalenes; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Rats; Rats, Wistar; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; RNA, Messenger; Sp1 Transcription Factor; Stress, Physiological; Transcription, Genetic; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2000
Activation of Rac1 and the p38 mitogen-activated protein kinase pathway in response to all-trans-retinoic acid.
    The Journal of biological chemistry, 2001, Feb-09, Volume: 276, Issue:6

    Topics: Cell Differentiation; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; rac1 GTP-Binding Protein; Tretinoin; Tumor Cells, Cultured

2001
Activation of pancreatic acinar cells on isolation from tissue: cytokine upregulation via p38 MAP kinase.
    American journal of physiology. Cell physiology, 2000, Volume: 279, Issue:6

    Topics: Animals; Chemokine CCL2; Chemokine CXCL1; Chemokine CXCL2; Chemokines; Chemokines, CXC; Cytokines; Enzyme Inhibitors; Gene Expression; Imidazoles; In Vitro Techniques; Interleukin-6; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pancreas; Pancreatitis; Pyridines; Rats; RNA, Messenger; Transcription Factor AP-1; Tumor Necrosis Factor-alpha

2000
p38 mitogen-activated protein kinase mediates tumor necrosis factor-alpha-induced apoptosis in rat fetal brown adipocytes.
    Endocrinology, 2000, Volume: 141, Issue:12

    Topics: Adipocytes; Adipose Tissue, Brown; Animals; Apoptosis; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-jun; Pyridines; Rats; Tumor Necrosis Factor-alpha

2000
Inhibitors of p38 MAP kinase increase the survival of transplanted dopamine neurons.
    Brain research, 2001, Feb-09, Volume: 891, Issue:1-2

    Topics: Animals; Brain Tissue Transplantation; Cell Survival; Cells, Cultured; Dopamine; Enzyme Inhibitors; Fetus; Graft Survival; Imidazoles; Male; Mitogen-Activated Protein Kinases; Neurons; p38 Mitogen-Activated Protein Kinases; Parkinsonian Disorders; Pyridines; Rats; Rats, Sprague-Dawley; Recovery of Function

2001
The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide-stimulated human macrophages.
    The Journal of biological chemistry, 2001, Apr-27, Volume: 276, Issue:17

    Topics: Arabidopsis Proteins; Base Sequence; Binding Sites; Cell Line; DNA-Binding Proteins; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epstein-Barr Virus Nuclear Antigens; Erythroid-Specific DNA-Binding Factors; Flavonoids; Flow Cytometry; Gene Expression Regulation, Enzymologic; Genes, Reporter; Humans; Imidazoles; Interleukin-10; Lipopolysaccharide Receptors; Lipopolysaccharides; Luciferases; Macrophages; Mitogen-Activated Protein Kinases; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases; Plant Proteins; Plasmids; Polymerase Chain Reaction; Promoter Regions, Genetic; Pyridines; Signal Transduction; Sp1 Transcription Factor; Time Factors; Transcription Factors; Transcription, Genetic; Transfection; Viral Proteins; YY1 Transcription Factor

2001
p38 MAP kinase negatively regulates cyclin D1 expression in airway smooth muscle cells.
    American journal of physiology. Lung cellular and molecular physiology, 2001, Volume: 280, Issue:5

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cells, Cultured; COS Cells; Cyclin D1; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; MAP Kinase Kinase 3; MAP Kinase Kinase 6; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle, Smooth; Mutation; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Precipitin Tests; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Pyridines; Rats; Recombinant Fusion Proteins; Trachea; Transcription, Genetic; Transfection

2001
The p38 MAPK pathway mediates the growth inhibitory effects of interferon-alpha in BCR-ABL-expressing cells.
    The Journal of biological chemistry, 2001, Jul-27, Volume: 276, Issue:30

    Topics: Androstadienes; Cell Division; Cell Line; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Genistein; Humans; Imidazoles; Immunoblotting; Interferon-alpha; Intracellular Signaling Peptides and Proteins; K562 Cells; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Tyrosine; Wortmannin

2001
The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation.
    Diabetes, 2001, Volume: 50, Issue:6

    Topics: 3T3 Cells; Androstadienes; Animals; Arabidopsis Proteins; Biological Transport; Deoxyglucose; Enzyme Inhibitors; Glucose; Glucose Transporter Type 4; Hypoglycemic Agents; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Monosaccharide Transport Proteins; Muscle Fibers, Skeletal; Muscle Proteins; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Plant Proteins; Potassium Channels; Pyridines; Thioctic Acid; Wortmannin

2001
Inhibitors of mitogen-activated protein kinases differentially regulate eosinophil-activating cytokine release from human airway smooth muscle.
    American journal of respiratory and critical care medicine, 2001, Aug-15, Volume: 164, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchi; Butadienes; Cytokines; Drug Evaluation, Preclinical; Eosinophils; Female; Flavonoids; Humans; Imidazoles; Lung Diseases, Obstructive; Male; MAP Kinase Kinase Kinase 1; Middle Aged; Mitogen-Activated Protein Kinases; Muscle, Smooth; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Up-Regulation

2001
IL-4 up-regulates the expression of tissue inhibitor of metalloproteinase-2 in dermal fibroblasts via the p38 mitogen-activated protein kinase dependent pathway.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Feb-15, Volume: 168, Issue:4

    Topics: Cells, Cultured; Dermis; Enzyme Inhibitors; Fibroblasts; Humans; Imidazoles; Interleukin-4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Mutation; p38 Mitogen-Activated Protein Kinases; Pyridines; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-2; Transcriptional Activation; Up-Regulation

2002
Activation of p38 mitogen-activated protein kinase during normal mitosis in the developing retina.
    Neuroscience, 2002, Volume: 112, Issue:3

    Topics: Aging; Anaphase; Animals; Animals, Newborn; Cell Cycle; Chromosomes; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Metaphase; Mitogen-Activated Protein Kinases; Mitosis; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Inbred Strains; Rats, Long-Evans; Reference Values; Retina

2002
Pyridinylimidazole p38 mitogen-activated protein kinase inhibitors block intracellular Toxoplasma gondii replication.
    International journal for parasitology, 2002, Volume: 32, Issue:8

    Topics: Animals; Butadienes; Cells, Cultured; Cholesterol; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Imidazoles; Inhibitory Concentration 50; Mitogen-Activated Protein Kinases; Mutation; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Toxoplasma

2002
Activation and translocation of p38 mitogen-activated protein kinase after stimulation of monocytes with contact sensitizers.
    The Journal of investigative dermatology, 2002, Volume: 119, Issue:1

    Topics: Benzalkonium Compounds; Biological Transport; Cytoplasm; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; ets-Domain Protein Elk-1; Haptens; Humans; Imidazoles; In Vitro Techniques; Interleukin-1; Irritants; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Monocytes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins; Pyridines; Transcription Factors

2002
Inhibition of p38 mitogen-activated protein kinase blocks activation of rat pancreatic stellate cells.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 304, Issue:1

    Topics: Actins; Androstadienes; Animals; Blotting, Northern; Blotting, Western; Cell Division; Cell Nucleus; Cells, Cultured; Chemokine CCL2; Electrophoresis; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Imidazoles; Interleukin-1; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pancreas; Phosphorylation; Platelet-Derived Growth Factor; Procollagen; Procollagen-Proline Dioxygenase; Protein Serine-Threonine Kinases; Pyridines; Rats; Wortmannin

2003
Interfering with TGFbeta-induced Smad3 nuclear accumulation differentially affects TGFbeta-dependent gene expression.
    Molecular cancer, 2003, Mar-19, Volume: 2

    Topics: Active Transport, Cell Nucleus; Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; DNA-Binding Proteins; Gene Expression Regulation; Humans; Imidazoles; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; RNA, Messenger; Smad3 Protein; Trans-Activators; Transcription, Genetic; Transforming Growth Factor beta

2003
Ligand-independent tyrosine kinase signalling in RTH 149 trout hepatoma cells: comparison among heavy metals and pro-oxidants.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2003, Volume: 13, Issue:3

    Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Copper; DNA-Binding Proteins; Dose-Response Relationship, Drug; Genistein; Hydrogen Peroxide; Imidazoles; Ligands; Mercury; Metals, Heavy; Milk Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oxidants; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Pyridines; Receptor Protein-Tyrosine Kinases; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; STAT5 Transcription Factor; Trans-Activators; Tyrosine

2003
A requirement for calcium-independent phospholipase A2 in thrombin-induced arachidonic acid release and growth in vascular smooth muscle cells.
    The Journal of biological chemistry, 2003, Oct-31, Volume: 278, Issue:44

    Topics: Animals; Arachidonic Acid; Blotting, Western; Coloring Agents; DNA; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Group VI Phospholipases A2; Imidazoles; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Naphthalenes; Oleic Acid; Oligonucleotides, Antisense; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Pyridines; Pyrones; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetrazolium Salts; Thiazoles; Thrombin; Time Factors

2003
The p38 mitogen-activated protein kinase pathway links the DNA mismatch repair system to the G2 checkpoint and to resistance to chemotherapeutic DNA-methylating agents.
    Molecular and cellular biology, 2003, Volume: 23, Issue:22

    Topics: Antineoplastic Agents, Alkylating; Base Pair Mismatch; Base Sequence; Cell Line, Tumor; Dacarbazine; DNA Methylation; DNA Repair; DNA, Neoplasm; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; G2 Phase; Humans; Imidazoles; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Temozolomide

2003
Suppression by p38 MAP kinase inhibitors (pyridinyl imidazole compounds) of Ah receptor target gene activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin and the possible mechanism.
    The Journal of biological chemistry, 2004, Jan-30, Volume: 279, Issue:5

    Topics: Animals; Blotting, Northern; Blotting, Western; Cell Line, Tumor; Chromatin; Cytochrome P-450 CYP1A1; Dioxins; Enzyme Inhibitors; Genes, Reporter; Histones; Humans; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Models, Chemical; p38 Mitogen-Activated Protein Kinases; Plasmids; Precipitin Tests; Pyridines; Receptors, Aryl Hydrocarbon; RNA; RNA, Messenger; Time Factors; Transcription, Genetic; Transfection

2004
Contribution of the p38MAPK signalling pathway to proliferation in human cultured airway smooth muscle cells is mitogen-specific.
    British journal of pharmacology, 2004, Volume: 142, Issue:7

    Topics: Blotting, Northern; Bronchi; Cell Cycle Proteins; Cell Proliferation; Cells, Cultured; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase Inhibitor p21; Fibroblast Growth Factor 2; Humans; Imidazoles; Mitogens; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Retinoblastoma Protein; RNA, Messenger; Signal Transduction; Thrombin

2004
Activation of endothelial nitric-oxide synthase by the p38 MAPK in response to black tea polyphenols.
    The Journal of biological chemistry, 2004, Nov-05, Volume: 279, Issue:45

    Topics: Adenoviridae; Animals; Aorta; Arginine; Blotting, Western; Calcium; Calmodulin; Catalysis; Citrulline; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genetic Vectors; Imidazoles; Immunoprecipitation; Mutation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; p38 Mitogen-Activated Protein Kinases; Phenols; Phosphatidylinositol 3-Kinases; Phosphorylation; Polyphenols; Pyridines; Signal Transduction; Swine; Tea; Time Factors; Transfection

2004
Cross-interactions of two p38 mitogen-activated protein (MAP) kinase inhibitors and two cholecystokinin (CCK) receptor antagonists with the CCK1 receptor and p38 MAP kinase.
    The Journal of biological chemistry, 2005, Jun-03, Volume: 280, Issue:22

    Topics: Adenosine Triphosphate; Animals; Benzodiazepinones; Binding Sites; Blotting, Western; COS Cells; Devazepide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genes, Reporter; Hormone Antagonists; Imidazoles; Immunoblotting; Inositol Phosphates; Kinetics; Ligands; MAP Kinase Signaling System; Models, Chemical; Models, Molecular; p38 Mitogen-Activated Protein Kinases; Phenylurea Compounds; Protein Binding; Protein Conformation; Pyridines; Rats; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Signal Transduction; Time Factors; Transfection

2005
Kinetic studies of small molecule interactions with protein kinases using biosensor technology.
    Analytical biochemistry, 2005, May-15, Volume: 340, Issue:2

    Topics: Binding Sites; Biosensing Techniques; Buffers; Enzymes, Immobilized; Imidazoles; Kinetics; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Pyrimidines; Substrate Specificity; Surface Plasmon Resonance

2005
DNFB activates MAPKs and upregulates CD40 in skin-derived dendritic cells.
    Journal of dermatological science, 2005, Volume: 39, Issue:2

    Topics: Active Transport, Cell Nucleus; Animals; Blotting, Western; CD40 Antigens; Cell Line; Cells, Cultured; Dendritic Cells; Dermatitis, Allergic Contact; Dinitrofluorobenzene; Dose-Response Relationship, Drug; Humans; Imidazoles; Immunohistochemistry; Kinetics; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Phenotype; Phosphorylation; Pyridines; Signal Transduction; Skin; Time Factors; Up-Regulation

2005
IL-6 activates serum and glucocorticoid kinase via p38alpha mitogen-activated protein kinase pathway.
    American journal of physiology. Cell physiology, 2005, Volume: 289, Issue:4

    Topics: Cell Line, Tumor; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Humans; Imidazoles; Immediate-Early Proteins; Interleukin-6; Isoenzymes; Mitogen-Activated Protein Kinase 14; Nuclear Proteins; Protein Serine-Threonine Kinases; Pyridines; RNA, Messenger; Signal Transduction

2005
An immunosorbent, nonradioactive p38 MAP kinase assay comparable to standard radioactive liquid-phase assays.
    Analytical biochemistry, 2005, Sep-01, Volume: 344, Issue:1

    Topics: Activating Transcription Factor 2; Enzyme Inhibitors; Imidazoles; Immunosorbent Techniques; Inhibitory Concentration 50; p38 Mitogen-Activated Protein Kinases; Pyridines; Staurosporine

2005
Epidermal growth factor stimulation of trophoblast differentiation requires MAPK11/14 (p38 MAP kinase) activation.
    Biology of reproduction, 2005, Volume: 73, Issue:6

    Topics: Cell Differentiation; Cell Fusion; Cell Proliferation; Cells, Cultured; Chorionic Gonadotropin, beta Subunit, Human; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Female; Humans; Imidazoles; Mitogen-Activated Protein Kinase 11; Mitogen-Activated Protein Kinase 14; Organ Culture Techniques; Placenta; Pregnancy; Pyridines; Trophoblasts

2005
Enzyme fragment complementation binding assay for p38alpha mitogen-activated protein kinase to study the binding kinetics of enzyme inhibitors.
    Assay and drug development technologies, 2006, Volume: 4, Issue:4

    Topics: Animals; Cell Line; Cell Line, Tumor; Dose-Response Relationship, Drug; Green Fluorescent Proteins; Humans; Imidazoles; Kinetics; Mitogen-Activated Protein Kinase 14; Molecular Structure; Naphthalenes; Peptide Fragments; Protein Binding; Protein Kinase Inhibitors; Protein Transport; Pyrazoles; Pyridines; Recombinant Fusion Proteins; Structure-Activity Relationship; Surface Plasmon Resonance

2006
Species and response dependent differences in the effects of MAPK inhibitors on P2X(7) receptor function.
    British journal of pharmacology, 2006, Volume: 149, Issue:7

    Topics: Adenosine Triphosphate; Animals; Calcium Signaling; Cell Line; Cell Membrane Permeability; Dose-Response Relationship, Drug; Ethidium; Humans; Imidazoles; Indicators and Reagents; Interleukin-1beta; Membrane Potentials; Mice; Mitogen-Activated Protein Kinases; Monocytes; Protein Kinase Inhibitors; Pyridines; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Recombinant Fusion Proteins; Species Specificity; Transfection

2006
Regulation of lipopolysaccharide-induced increases in neutrophil glucose uptake.
    American journal of physiology. Lung cellular and molecular physiology, 2007, Volume: 292, Issue:4

    Topics: Animals; Glucose; Glucose Transporter Type 1; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Isoquinolines; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Neutrophils; p38 Mitogen-Activated Protein Kinases; Protein Transport; Pyridines

2007
p38 mitogen-activated protein kinase mediates adenosine-induced alterations in myocardial glucose utilization via 5'-AMP-activated protein kinase.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 292, Issue:4

    Topics: Adenosine; AMP-Activated Protein Kinases; Animals; Coronary Circulation; Enzyme Inhibitors; Glucose; Glycogen; Imidazoles; Male; Multienzyme Complexes; Myocardial Ischemia; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley

2007
Inhibition of p38 mitogen-activated protein kinase-induced apoptosis in cultured mature oligodendrocytes using SB202190 and SB203580.
    Neurochemistry international, 2007, Volume: 51, Issue:1

    Topics: Adenosine Triphosphate; Animals; Apoptosis; Caspases; Cell Differentiation; Cell Line; Cell Survival; Enzyme Inhibitors; Imidazoles; Oligodendroglia; p38 Mitogen-Activated Protein Kinases; Phosphoric Monoester Hydrolases; Pyridines; Rats; Rats, Wistar; Stem Cells

2007
The role of p38 mitogen-activated kinase (MAPK) in the mechanism regulating cyclooxygenase gene expression in equine leukocytes.
    Veterinary immunology and immunopathology, 2007, Aug-15, Volume: 118, Issue:3-4

    Topics: Animals; Cells, Cultured; Cyclooxygenase 2; Enzyme Activation; Epoprostenol; Gene Expression Regulation, Enzymologic; Horses; Imidazoles; Leukocytes; p38 Mitogen-Activated Protein Kinases; Prostaglandins; Pyridines; RNA, Messenger; Time Factors

2007
p38 MAPK, but not ERK1/2, is critically involved in the cytotoxicity of the novel vascular disrupting agent combretastatin A4.
    International journal of cancer, 2008, Apr-15, Volume: 122, Issue:8

    Topics: Angiogenesis Inhibitors; Antineoplastic Agents, Phytogenic; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Fluorescent Antibody Technique; Humans; Imidazoles; Liver Neoplasms; Male; Microtubules; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Pyridines; Stilbenes; Time Factors

2008
Activation of c-Jun N-terminal kinase (JNK) by widely used specific p38 MAPK inhibitors SB202190 and SB203580: a MLK-3-MKK7-dependent mechanism.
    Cellular signalling, 2008, Volume: 20, Issue:4

    Topics: Activating Transcription Factor 2; Cell Line, Tumor; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Enzyme Activators; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 7; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinase Kinase 11; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-jun; Pyridines; RNA Interference; RNA, Small Interfering; Transcription Factor AP-1; Transfection

2008
p38 MAP kinase mediates arsenite-induced apoptosis through FOXO3a activation and induction of Bim transcription.
    Apoptosis : an international journal on programmed cell death, 2008, Volume: 13, Issue:6

    Topics: Animals; Apoptosis; Arsenites; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Enzyme Activation; Forkhead Box Protein O3; Forkhead Transcription Factors; Imidazoles; JNK Mitogen-Activated Protein Kinases; Models, Biological; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Protein Transport; Pyridines; Rats; RNA Interference; Sodium Compounds; Up-Regulation

2008
Chlorobenzene induces the NF-kappa B and p38 MAP kinase pathways in lung epithelial cells.
    Inhalation toxicology, 2008, Volume: 20, Issue:9

    Topics: Cell Line; Chemokine CCL2; Chlorobenzenes; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Formazans; Gene Expression; Humans; Imidazoles; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pulmonary Alveoli; Pyridines; Respiratory Mucosa; RNA, Messenger; Tetrazolium Salts; Tumor Necrosis Factor-alpha

2008
Antiproliferative effects of CC-8062 and CC-8075 in pancreatic cancer cells.
    Pancreas, 2009, Volume: 38, Issue:1

    Topics: Alitretinoin; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Humans; Imidazoles; p38 Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Tretinoin

2009
C-reactive protein modulates human lung fibroblast migration.
    Experimental lung research, 2009, Volume: 35, Issue:1

    Topics: C-Reactive Protein; Cell Migration Assays; Cell Migration Inhibition; Cells, Cultured; Chemotaxis; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Fibronectins; Humans; Imidazoles; Lipopolysaccharides; Lung; p38 Mitogen-Activated Protein Kinases; Pyridines; Sodium Azide

2009
Non-specific in vivo inhibition of CK1 by the pyridinyl imidazole p38 inhibitors SB 203580 and SB 202190.
    BMB reports, 2009, Mar-31, Volume: 42, Issue:3

    Topics: Casein Kinase I; Cell Line; Cyclic AMP Response Element-Binding Protein; Humans; Imidazoles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphoserine; Protein Biosynthesis; Protein Kinase Inhibitors; Pyridines; Stress, Physiological; Substrate Specificity; Suppression, Genetic

2009
The p38 mitogen-activated protein kinase regulates 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) expression in human trophoblast cells through modulation of 11beta-HSD2 messenger ribonucleic acid stability.
    Endocrinology, 2009, Volume: 150, Issue:9

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Cells, Cultured; Corticotropin-Releasing Hormone; Epidermal Growth Factor; Female; Gene Expression Regulation, Developmental; Humans; Imidazoles; p38 Mitogen-Activated Protein Kinases; Pregnancy; Pyridines; Pyrimidines; RNA, Messenger; RNA, Small Interfering; Trophoblasts

2009
Cochlear protection from acoustic injury by inhibitors of p38 mitogen-activated protein kinase and sequestosome 1 stress protein.
    Neuroscience, 2010, Mar-17, Volume: 166, Issue:2

    Topics: Acoustic Stimulation; Adaptor Proteins, Signal Transducing; Analysis of Variance; Animals; Cochlea; Cytoprotection; Dose-Response Relationship, Drug; Enzyme Inhibitors; Evoked Potentials, Auditory, Brain Stem; Heat-Shock Proteins; Imidazoles; Mice; Mice, Knockout; p38 Mitogen-Activated Protein Kinases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequestosome-1 Protein

2010
p38 regulates pigmentation via proteasomal degradation of tyrosinase.
    The Journal of biological chemistry, 2010, Mar-05, Volume: 285, Issue:10

    Topics: alpha-MSH; Animals; Enzyme Inhibitors; Enzyme Stability; Gene Expression Regulation; Humans; Imidazoles; MAP Kinase Signaling System; Melanins; Melanoma, Experimental; Mice; Microphthalmia-Associated Transcription Factor; Monophenol Monooxygenase; p38 Mitogen-Activated Protein Kinases; Pigmentation; Proteasome Endopeptidase Complex; Pyridines; RNA, Small Interfering; Ubiquitinated Proteins; Ultraviolet Rays

2010
Oxidized low-density lipoprotein increases interleukin-8 production in human gingival epithelial cell line Ca9-22.
    Journal of periodontal research, 2010, Volume: 45, Issue:4

    Topics: Cell Line, Tumor; Chemokine CCL2; Cholesterol 7-alpha-Hydroxylase; Dextran Sulfate; Dinoprostone; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Fucose; Gingiva; Humans; Imidazoles; Interleukin-1beta; Interleukin-8; Ketocholesterols; Lipoproteins, LDL; Mitogen-Activated Protein Kinases; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Periodontitis; Polysaccharides; Pyridines; Receptors, Scavenger; Sulfuric Acid Esters

2010
Resistin induces monocyte-endothelial cell adhesion by increasing ICAM-1 and VCAM-1 expression in endothelial cells via p38MAPK-dependent pathway.
    Journal of cellular physiology, 2011, Volume: 226, Issue:8

    Topics: Cell Adhesion; Cell Line; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Humans; Imidazoles; Intercellular Adhesion Molecule-1; Monocytes; p38 Mitogen-Activated Protein Kinases; Pyridines; Resistin; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1

2011
cPLA(2)α gene activation by IL-1β is dependent on an upstream kinase pathway, enzymatic activation and downstream 15-lipoxygenase activity: a positive feedback loop.
    Cellular signalling, 2011, Volume: 23, Issue:12

    Topics: Animals; Arachidonate 15-Lipoxygenase; Cell Line; Enzyme Activation; Feedback, Physiological; Fluorenes; Gene Expression; Gene Knockout Techniques; Group IV Phospholipases A2; Humans; Imidazoles; Interleukin-1beta; Isoenzymes; Lipoxygenase Inhibitors; Luteolin; MAP Kinase Kinase 3; MAP Kinase Kinase 6; MAP Kinase Signaling System; Masoprocol; Mice; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Ribosomal Protein S6 Kinases, 90-kDa; Transcriptional Activation

2011
Negative regulation of human U6 snRNA promoter by p38 kinase through Oct-1.
    Gene, 2012, Apr-15, Volume: 497, Issue:2

    Topics: DNA-Binding Proteins; Down-Regulation; Humans; Imidazoles; Jurkat Cells; Mutation; Octamer Transcription Factor-1; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Pyridines; Regulatory Sequences, Nucleic Acid; RNA, Small Nuclear; Transcription, Genetic; Tumor Cells, Cultured

2012
KCa3.1 channels mediate the increase of cell migration and proliferation by advanced glycation endproducts in cultured rat vascular smooth muscle cells.
    Laboratory investigation; a journal of technical methods and pathology, 2013, Volume: 93, Issue:2

    Topics: Analysis of Variance; Androstadienes; Animals; Blotting, Western; Butadienes; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Flavonoids; Glycation End Products, Advanced; Imidazoles; Intermediate-Conductance Calcium-Activated Potassium Channels; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; Patch-Clamp Techniques; Pyridines; Rats; RNA Interference; RNA, Small Interfering; Serum Albumin, Bovine; Signal Transduction; Wortmannin

2013
Cyclic tensile force up-regulates BMP-2 expression through MAP kinase and COX-2/PGE2 signaling pathways in human periodontal ligament cells.
    Experimental cell research, 2014, Apr-15, Volume: 323, Issue:1

    Topics: Adult; Bite Force; Bone Morphogenetic Protein 2; Butadienes; Calcification, Physiologic; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Humans; Imidazoles; Male; Mastication; Molar, Third; Nitriles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Stress, Physiological; Sulfonamides; Up-Regulation; Young Adult

2014
The problem of pyridinyl imidazole class inhibitors of MAPK14/p38α and MAPK11/p38β in autophagy research.
    Autophagy, 2015, Volume: 11, Issue:8

    Topics: Autophagy; Autophagy-Related Proteins; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; HeLa Cells; HT29 Cells; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Inflammation; Membrane Proteins; Mitogen-Activated Protein Kinase 11; Mitogen-Activated Protein Kinase 14; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Signal Transduction; Vesicular Transport Proteins

2015
Mitochondrial-generated ROS down regulates insulin signaling via activation of the p38MAPK stress response pathway.
    Molecular and cellular endocrinology, 2016, Jan-05, Volume: 419

    Topics: Animals; Cells, Cultured; Hepatocytes; Imidazoles; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; MAP Kinase Signaling System; Mice; Mitochondria; Phosphorylation; Pyridines; Reactive Oxygen Species; Rotenone; Transcriptome

2016
p38 MAPK as an essential regulator of dorsal-ventral axis specification and skeletogenesis during sea urchin development: a re-evaluation.
    Development (Cambridge, England), 2017, 06-15, Volume: 144, Issue:12

    Topics: Amino Acid Sequence; Animals; Body Patterning; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Imidazoles; MAP Kinase Signaling System; Morphogenesis; Mutation; Nodal Signaling Ligands; p38 Mitogen-Activated Protein Kinases; Paracentrotus; Phenotype; Protein Kinase Inhibitors; Pyridines; Sequence Homology, Amino Acid; Signal Transduction

2017
1α,25-Dihydroxyvitamin D
    The Journal of steroid biochemistry and molecular biology, 2017, Volume: 172

    Topics: Calcium Channels; Cell Cycle Proteins; Cell Line, Tumor; Gene Expression Regulation; Humans; Imidazoles; Intestinal Mucosa; Isoenzymes; Mitogen-Activated Protein Kinase 14; Nuclear Proteins; Protein Kinase Inhibitors; Pyridines; Receptors, Calcitriol; RNA, Small Interfering; Signal Transduction; Transcription, Genetic; TRPV Cation Channels; Vitamin D; Vitamin D3 24-Hydroxylase

2017
Cell-permeable p38 MAP kinase protects adult hippocampal neurons from cell death.
    Neuroscience letters, 2019, 04-23, Volume: 699

    Topics: Animals; Cell Death; Cells, Cultured; Hippocampus; Hypoglycemia; Imidazoles; Mice; Neurons; Neuroprotection; p38 Mitogen-Activated Protein Kinases; Pyridines

2019
p38MAPK controls fibroblast growth factor 23 (FGF23) synthesis in UMR106-osteoblast-like cells and in IDG-SW3 osteocytes.
    Journal of endocrinological investigation, 2019, Volume: 42, Issue:12

    Topics: Animals; Anisomycin; Cell Line; Enzyme Inhibitors; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Flavanones; Gene Expression Regulation; Imidazoles; Mice; NF-kappa B; Osteoblasts; Osteocytes; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Signal Transduction; Withanolides

2019