Compounds > sb 203580
Page last updated: 2024-09-05

sb 203580 and s 1033

sb 203580 has been researched along with s 1033 in 7 studies

Compound Research Comparison

Studies
(sb 203580)		Trials
(sb 203580)		Recent Studies (post-2010)
(sb 203580)		Studies
(s 1033)		Trials
(s 1033)		Recent Studies (post-2010) (s 1033)
3,48941,1371,4071471,074

Protein Interaction Comparison

ProteinTaxonomysb 203580 (IC50)s 1033 (IC50)
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)4.7
Solute carrier family 22 member 3Homo sapiens (human)0.5
Tyrosine-protein kinase ABL1Homo sapiens (human)0.34
Low-density lipoprotein receptorHomo sapiens (human)9.8
FibronectinHomo sapiens (human)0.12
RAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)1.1
Tyrosine-protein kinase LckHomo sapiens (human)0.1082
Macrophage colony-stimulating factor 1 receptorHomo sapiens (human)0.677
Tyrosine-protein kinase LynHomo sapiens (human)1.281
Cytochrome P450 3A4Homo sapiens (human)0.58
Macrophage colony-stimulating factor 1 receptorMus musculus (house mouse)0.534
Platelet-derived growth factor receptor betaHomo sapiens (human)0.052
Mast/stem cell growth factor receptor KitHomo sapiens (human)0.1115
Breakpoint cluster region proteinHomo sapiens (human)0.0575
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)1.01
Solute carrier family 2, facilitated glucose transporter member 4Mus musculus (house mouse)0.042
Ribosyldihydronicotinamide dehydrogenase [quinone]Homo sapiens (human)1.0905
Platelet-derived growth factor receptor alphaHomo sapiens (human)0.0368
Ephrin type-A receptor 2Homo sapiens (human)0.033
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)9.548
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)4.7
Epithelial discoidin domain-containing receptor 1Homo sapiens (human)0.0371
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.2879
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)4.7
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)4.7
Discoidin domain-containing receptor 2Homo sapiens (human)0.0289
Proprotein convertase subtilisin/kexin type 9Homo sapiens (human)9.8
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)2.5

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's4 (57.14)24.3611
2020's2 (28.57)2.80

Authors

AuthorsStudies
Chen, YD; Jiao, Y; Li, HF; Lu, T; Wang, X; Zhang, LY; Zhu, T1
Ciceri, P; Davis, MI; Herrgard, S; Hocker, M; Hunt, JP; Pallares, G; Treiber, DK; Wodicka, LM; Zarrinkar, PP1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Munoz, L1
Bharate, SB; Raghuvanshi, R1
Caballero, E; García-Cárceles, J; Gil, C; Martínez, A1
Dong, Q; Ge, J; Huang, Q; Tian, S; Zhao, L; Zhu, H1

Reviews

2 review(s) available for sb 203580 and s 1033

ArticleYear
Non-kinase targets of protein kinase inhibitors.
    Nature reviews. Drug discovery, 2017, Volume: 16, Issue:6

    Topics: Animals; Drug Design; Drug Evaluation, Preclinical; Humans; Molecular Targeted Therapy; Protein Kinase Inhibitors; Protein Kinases

2017
Kinase Inhibitors as Underexplored Antiviral Agents.
    Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2

    Topics: Animals; Antiviral Agents; Drug Repositioning; Humans; Protein Kinase Inhibitors; Virus Diseases; Viruses

2022

Other Studies

5 other study(ies) available for sb 203580 and s 1033

ArticleYear
Pharmacophore identification of Raf-1 kinase inhibitors.
    Bioorganic & medicinal chemistry letters, 2008, Apr-01, Volume: 18, Issue:7

    Topics: Binding Sites; Biological Transport; Enzyme Inhibitors; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Models, Biological; Models, Chemical; Proto-Oncogene Proteins c-raf; Structure-Activity Relationship

2008
Comprehensive analysis of kinase inhibitor selectivity.
    Nature biotechnology, 2011, Oct-30, Volume: 29, Issue:11

    Topics: Catalysis; Drug Design; Enzyme Stability; High-Throughput Screening Assays; Humans; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Proteomics; Signal Transduction; Substrate Specificity

2011
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections.
    Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2

    Topics: Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Drug Approval; Drug Repositioning; High-Throughput Screening Assays; Humans; Protein Kinase Inhibitors; SARS-CoV-2; United States; United States Food and Drug Administration; Virus Diseases

2022
Integrative identification of unexpected kinase-inhibitor interactions in the MAPK-mediated proliferation and differentiation of Mc3T3-E1 osteoblasts.
    General physiology and biophysics, 2019, Volume: 38, Issue:1

    Topics: Aniline Compounds; Animals; Anthracenes; Cell Differentiation; Cell Line; Cell Proliferation; Dasatinib; Imidazoles; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase Kinases; Nitriles; Osteoblasts; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Quinolines

2019