sb 203580 and rottlerin

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides

Topics: beta-Lactamase Inhibitors; beta-Lactamases; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Biological; Phosphotransferases; Scattering, Radiation

Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera

Topics: Animals; Cell Line, Tumor; Drug Evaluation, Preclinical; Flow Cytometry; Humans; Janus Kinases; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Phosphorus; Sensitivity and Specificity; Signal Transduction; STAT Transcription Factors

Topics: Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Drug Approval; Drug Repositioning; High-Throughput Screening Assays; Humans; Protein Kinase Inhibitors; SARS-CoV-2; United States; United States Food and Drug Administration; Virus Diseases

Topics: Acetophenones; Benzopyrans; Cell Division; Cycloheximide; DNA Damage; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; GADD45 Proteins; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Isoenzymes; Kinetics; Leupeptins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Proteins; Pyridines; Recombinant Proteins; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Ubiquitins

Topics: Acetophenones; Aldehyde Reductase; Animals; Benzopyrans; Blotting, Western; Enzyme Inhibitors; Fibroblasts; Genes, Reporter; Imidazoles; Isoenzymes; Luciferases; Mice; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trans-Activators; Transcription Factors; Transcription, Genetic

Topics: Acetophenones; Androstadienes; Animals; Benzopyrans; Brefeldin A; Butadienes; Cell Communication; Cells, Cultured; Cricetinae; Cricetulus; Enzyme Inhibitors; Flavonoids; Gap Junctions; Imidazoles; Indoles; Maleimides; Mesocricetus; Mitogen-Activated Protein Kinases; Nitriles; Peroxisome Proliferators; Protein Kinase C; Protein Synthesis Inhibitors; Pyridines; Pyrimidines; Signal Transduction; Sirolimus; Wortmannin

Topics: Acetophenones; Animals; Aorta; Benzopyrans; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Indoles; Kinetics; Maleimides; Muscle, Smooth, Vascular; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Pyridines; Rats; Thrombin

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Androstadienes; Animals; Antibodies; Benzophenanthridines; Benzopyrans; Blotting, Western; Brain-Derived Neurotrophic Factor; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carbazoles; Cell Nucleus; Chromones; Cyclic AMP Response Element-Binding Protein; Cytosol; Enzyme Inhibitors; Flavonoids; Hippocampus; Imidazoles; Immunohistochemistry; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Male; Morpholines; Naphthalenes; Phenanthridines; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Rats; Signal Transduction; Time Factors; Tyrphostins; Wortmannin

Topics: Acetophenones; Benzopyrans; Carbazoles; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Indoles; Interferon gamma Receptor; Interferon-gamma; Isoenzymes; Mesylates; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphoserine; Protein Kinase C; Protein Kinase C-delta; Pyridines; Pyrroles; Receptors, Interferon; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Tumor Cells, Cultured

Topics: Acetophenones; Adenosine Triphosphate; Benzopyrans; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; CD18 Antigens; Cell Aggregation; Cycloheximide; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; Indoles; Integrin beta1; Isoenzymes; Maleimides; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Phosphotransferases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Staurosporine; Temperature; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; U937 Cells

Topics: Acetophenones; Benzopyrans; Blotting, Western; Carbazoles; Cell Adhesion Molecules; Cells, Cultured; E-Selectin; Endothelium, Vascular; Estrenes; Histamine; Histamine Agonists; Humans; Imidazoles; Indoles; Intercellular Adhesion Molecule-1; Lysophospholipids; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Pyridines; Pyrrolidinones; RNA, Messenger; Signal Transduction; Sphingosine; Type C Phospholipases; Umbilical Veins; Vascular Cell Adhesion Molecule-1

Topics: Acetophenones; Animals; Benzopyrans; Carbazoles; CD11b Antigen; Cell Differentiation; Cells, Cultured; Cholecalciferol; Enzyme Activation; Enzyme Inhibitors; Glycoproteins; Imidazoles; Indoles; Macrophage Colony-Stimulating Factor; Maleimides; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Monocytes; Osteoprotegerin; p38 Mitogen-Activated Protein Kinases; Phorbol Esters; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Pyridines; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor

Topics: Acetophenones; Benzopyrans; Cell Adhesion; Cell Line; Cell Movement; Enzyme Inhibitors; Epithelial Cells; Humans; Imidazoles; Instillation, Drug; Isoenzymes; Leukocytes; Lung; Neutrophil Infiltration; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Kinase C-delta; Pyridines; Trachea; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Cell Adhesion Molecule-1

Topics: Acetophenones; Animals; Benzopyrans; Cells, Cultured; Cytokines; Enzyme Inhibitors; Escherichia coli; Imidazoles; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Phosphoserine; Protein Kinase C-delta; Pyridines; Signal Transduction; STAT1 Transcription Factor; Toll-Like Receptor 2; Toll-Like Receptor 4

Topics: Acetophenones; Acrolein; Animals; Atherosclerosis; Benzopyrans; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Induction; Humans; Imidazoles; Lung; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Protein Kinase C-delta; Protein Kinase Inhibitors; Pyridines; RNA, Messenger; Smoking; Time Factors; Transcription, Genetic; Umbilical Veins

Topics: Acetophenones; Benzopyrans; Butadienes; Chromones; Gene Expression Regulation, Enzymologic; Genistein; Hexosaminidases; Humans; Imidazoles; Macrophages; MAP Kinase Signaling System; Monocytes; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphorylation; Prolactin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; RNA, Messenger; Tyrphostins

Topics: Acetophenones; Annexin A1; Annexin A2; Benzopyrans; Endocytosis; Endosomes; Gene Knockdown Techniques; HeLa Cells; Humans; Imidazoles; p38 Mitogen-Activated Protein Kinases; Phospholipase A2 Inhibitors; Phospholipases A2; Protein Binding; Protein Kinase C-delta; Protein Transport; Pyridines; Receptor, IGF Type 2; Ricin; RNA, Small Interfering; Shiga Toxin; trans-Golgi Network

Topics: Acetophenones; Benzopyrans; Cell Adhesion; Chemokine CCL2; Fibroblasts; Gene Expression Regulation; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 14; Osteoarthritis; Pyridines; Receptors, CCR2; Signal Transduction; Synovial Fluid; Transcription Factor AP-1; Vascular Cell Adhesion Molecule-1