Page last updated: 2024-09-05

sb 203580 and roflumilast

sb 203580 has been researched along with roflumilast in 2 studies

Compound Research Comparison

Studies (sb 203580)	Trials (sb 203580)	Recent Studies (post-2010) (sb 203580)	Studies (roflumilast)	Trials (roflumilast)	Recent Studies (post-2010) (roflumilast)
3,489	4	1,137	566	90	425

Protein Interaction Comparison

Protein	Taxonomy	roflumilast (IC50)
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0008
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0008
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0008
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0008
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0008
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0008
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.0008
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.0008
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.0008
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.0008
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0008
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0008
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	Homo sapiens (human)	0.0008
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	Homo sapiens (human)	0.0008
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.0058
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.0058
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.0058
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.0058
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.0058
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.0058
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.0058
cGMP-dependent 3',5'-cyclic phosphodiesterase	Homo sapiens (human)	0.0008
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	Homo sapiens (human)	0.0008
cGMP-specific 3',5'-cyclic phosphodiesterase	Homo sapiens (human)	0.0008
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	Homo sapiens (human)	0.0005
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	0.0003
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	Homo sapiens (human)	0.0008
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	Homo sapiens (human)	0.025
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	Homo sapiens (human)	0.0008
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	0.0475
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Homo sapiens (human)	0.0008
Beta-2 adrenergic receptor	Cavia porcellus (domestic guinea pig)	0.001
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	Homo sapiens (human)	0.0008
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	Homo sapiens (human)	0.0008
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Homo sapiens (human)	0.0008

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Barlow, DJ; Ehrman, TM; Hylands, PJ	1
Albrecht, W; Bauer, SM; Laufer, SA; Unger, A	1

Other Studies

2 other study(ies) available for sb 203580 and roflumilast

Article	Year
In silico search for multi-target anti-inflammatories in Chinese herbs and formulas. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Anti-Inflammatory Agents; Crystallography, X-Ray; Cyclooxygenase 1; Cyclooxygenase 2; Databases, Factual; Drug Design; Drugs, Chinese Herbal; Enzyme Inhibitors; JNK Mitogen-Activated Protein Kinases; Medicine, Chinese Traditional; Models, Chemical; Models, Molecular; Molecular Conformation; p38 Mitogen-Activated Protein Kinases; Phosphodiesterase 4 Inhibitors; Structure-Activity Relationship	2010
Discovery of N-{4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-acetamide (CBS-3595), a Dual p38α MAPK/PDE-4 Inhibitor with Activity against TNFα-Related Diseases. Journal of medicinal chemistry, 2017, 07-13, Volume: 60, Issue:13 Topics: Aminopyridines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Discovery; Humans; Imidazoles; Inflammation; Mitogen-Activated Protein Kinase 14; Phosphodiesterase 4 Inhibitors; Protein Kinase Inhibitors; Tumor Necrosis Factor-alpha	2017

Article

Year

In silico search for multi-target anti-inflammatories in Chinese herbs and formulas.

Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

Topics: Anti-Inflammatory Agents; Crystallography, X-Ray; Cyclooxygenase 1; Cyclooxygenase 2; Databases, Factual; Drug Design; Drugs, Chinese Herbal; Enzyme Inhibitors; JNK Mitogen-Activated Protein Kinases; Medicine, Chinese Traditional; Models, Chemical; Models, Molecular; Molecular Conformation; p38 Mitogen-Activated Protein Kinases; Phosphodiesterase 4 Inhibitors; Structure-Activity Relationship

2010

Discovery of N-{4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-acetamide (CBS-3595), a Dual p38α MAPK/PDE-4 Inhibitor with Activity against TNFα-Related Diseases.

Journal of medicinal chemistry, 2017, 07-13, Volume: 60, Issue:13

Topics: Aminopyridines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Discovery; Humans; Imidazoles; Inflammation; Mitogen-Activated Protein Kinase 14; Phosphodiesterase 4 Inhibitors; Protein Kinase Inhibitors; Tumor Necrosis Factor-alpha

2017