Page last updated: 2024-09-05

sb 203580 and ro 31-8220

sb 203580 has been researched along with ro 31-8220 in 25 studies

Compound Research Comparison

Studies (sb 203580)	Trials (sb 203580)	Recent Studies (post-2010) (sb 203580)	Studies (ro 31-8220)	Trials (ro 31-8220)	Recent Studies (post-2010) (ro 31-8220)
3,489	4	1,137	587	1	64

Protein Interaction Comparison

Protein	Taxonomy	ro 31-8220 (IC50)
Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)	0.008
Serine/threonine-protein kinase 10	Homo sapiens (human)	0.099
cAMP-dependent protein kinase catalytic subunit alpha	Bos taurus (cattle)	0.9
Serine/threonine-protein kinase pim-1	Homo sapiens (human)	0.01
Protein kinase C alpha type	Homo sapiens (human)	0.033
Glycogen synthase kinase-3 beta	Rattus norvegicus (Norway rat)	0.0068
Ribosomal protein S6 kinase beta-1	Homo sapiens (human)	0.015
Mitogen-activated protein kinase kinase kinase 8	Homo sapiens (human)	9.95
Glycogen synthase kinase-3 beta	Homo sapiens (human)	0.0116
Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)	0.01
Protein kinase C beta type	Rattus norvegicus (Norway rat)	0.01
Homeodomain-interacting protein kinase 1	Homo sapiens (human)	0.621
NAD-dependent protein deacetylase sirtuin-2	Homo sapiens (human)	0.875
Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)	0.0529
NAD-dependent protein deacetylase sirtuin-1	Homo sapiens (human)	3.9
Serine/threonine-protein kinase VRK1	Homo sapiens (human)	0.743
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Homo sapiens (human)	3.7
Serine/threonine-protein kinase TBK1	Homo sapiens (human)	0.656

Research

Studies (25)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (16.00)	18.2507
2000's	20 (80.00)	29.6817
2010's	1 (4.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Caivano, M; Cohen, P; Davies, SP; Reddy, H	1
McGovern, SL; Shoichet, BK	1
Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N	1
Engel, K; Gaestel, M; Schultz, H	1
Abdel-Latif, AA; Husain, S	1
Barnes, PJ; Giembycz, MA; Hellewell, PG; Lindsay, MA; Lynch, OT	1
Ezumi, Y; Hirai, K; Nishida, E; Takayama, H; Uchiyama, T	1
Akkerman, JW; Gorter, G; van Willigen, G	1
Dickenson, JM; Germack, R	1
Joe, E; Jou, I; Pyo, H; Ryu, J	1
Alessi, DR; Cuenda, A	1
Chen, CC; Chen, JJ; Chou, CY	1
Hirata , K; Inoue, N; Kawashima, S; Kojima, Y; Rikitake, Y; Shimokawa, Y; Takeuchi, S; Yokoyama, M	1
Barnes, PJ; Giembycz, MA; Lindsay, MA; Lynch, OT	1
Chen, BC; Lin, WW	1
Grijalva, R; Klos, K; Li, P; Nguyen, N; Xiong, S; Yao, J; Yu, D	1
Maher, P	1
Cui, MZ; Ogawa, W; Ohba, M; Tan, M; Xu, X	1
Baek, SH; Chung, JH; Jeon, JY; Kim, YD; Lee, JC; Song, SY; Woo, HJ; Yoon, SK	1
Dai, J; Remick, DG; Wang, X; Zeng, X	1
DiMattina, AJ; Holland, JA; Johnson, DK; O'Donnell, RW; Stone, RI; Ziegler, LM	1
Franklin, RA; Howe, CJ; Lahair, MM; McCubrey, JA; Rodriguez-Mora, OG	1
Clugston, A; Dransfield, I; Haslett, C; Murray, J; Rossi, AG; Ward, C	1
Chang, YL; Guh, JH; Huang, DY; Pan, SL; Sun, HL; Tao, KY; Teng, CM	1
Avni, D; Meijler, MM; Philosoph, A; Zor, T	1

Reviews

1 review(s) available for sb 203580 and ro 31-8220

Article	Year
Use of kinase inhibitors to dissect signaling pathways. Methods in molecular biology (Clifton, N.J.), 2000, Volume: 99 Topics: Androstadienes; Animals; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Maleimides; Morpholines; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Sirolimus; Wortmannin	2000

Other Studies

24 other study(ies) available for sb 203580 and ro 31-8220

Article	Year
Specificity and mechanism of action of some commonly used protein kinase inhibitors. The Biochemical journal, 2000, Oct-01, Volume: 351, Issue:Pt 1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides	2000
Kinase inhibitors: not just for kinases anymore. Journal of medicinal chemistry, 2003, Apr-10, Volume: 46, Issue:8 Topics: beta-Lactamase Inhibitors; beta-Lactamases; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Biological; Phosphotransferases; Scattering, Radiation	2003
The selectivity of protein kinase inhibitors: a further update. The Biochemical journal, 2007, Dec-15, Volume: 408, Issue:3 Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera	2007
PMA-induced activation of the p42/44ERK- and p38RK-MAP kinase cascades in HL-60 cells is PKC dependent but not essential for differentiation to the macrophage-like phenotype. Journal of cellular physiology, 1997, Volume: 173, Issue:3 Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; HL-60 Cells; Humans; Imidazoles; Indoles; Intracellular Signaling Peptides and Proteins; Macrophages; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Myelin Basic Protein; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Substrate Specificity; Tetradecanoylphorbol Acetate	1997
Endothelin-1 activates p38 mitogen-activated protein kinase and cytosolic phospholipase A2 in cat iris sphincter smooth muscle cells. The Biochemical journal, 1999, Aug-15, Volume: 342 ( Pt 1) Topics: Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cats; Cells, Cultured; Cyclic AMP; Cytosol; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Activation; Flavonoids; GTP-Binding Proteins; Imidazoles; Indoles; Intercellular Signaling Peptides and Proteins; Iris; Mitogen-Activated Protein Kinases; Muscle, Smooth; p38 Mitogen-Activated Protein Kinases; Peptides; Pertussis Toxin; Phospholipases A; Phospholipases A2; Phosphorylation; Pyridines; Receptors, Endothelin; Virulence Factors, Bordetella; Wasp Venoms	1999
'Outside-in' signalling mechanisms underlying CD11b/CD18-mediated NADPH oxidase activation in human adherent blood eosinophils. British journal of pharmacology, 1999, Volume: 128, Issue:6 Topics: Androstadienes; Carbazoles; CD18 Antigens; Cell Adhesion; Cell Count; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Eosinophils; Humans; Imidazoles; Indoles; Isoenzymes; Macrophage-1 Antigen; Maleimides; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyrazoles; Pyridines; Pyrimidines; Signal Transduction; src-Family Kinases; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin	1999
Comparative study of vanadate- and phorbol ester-induced cyclo-oxygenase-2 expression in human endothelial cells. Thrombosis and haemostasis, 1999, Volume: 82, Issue:5 Topics: Cyclooxygenase 2; Endothelium, Vascular; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Isoenzymes; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Tetradecanoylphorbol Acetate; Tyrphostins; Vanadates	1999
Thrombopoietin increases platelet sensitivity to alpha-thrombin via activation of the ERK2-cPLA2 pathway. Thrombosis and haemostasis, 2000, Volume: 83, Issue:4 Topics: Animals; Blood Platelets; Carbazoles; Cattle; Cytoplasmic Granules; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Group IV Phospholipases A2; Humans; Imidazoles; Indoles; Indomethacin; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Aggregation; Protein Kinase C; Protein Processing, Post-Translational; Pyridines; Serotonin; Serum Albumin, Bovine; Thrombin; Thrombopoietin; Thromboxane A2	2000
Activation of protein kinase B by the A(1)-adenosine receptor in DDT(1)MF-2 cells. British journal of pharmacology, 2000, Volume: 130, Issue:4 Topics: Adenosine; Androstadienes; Animals; Calcium; Cell Line; Chromones; Cricetinae; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Imidazoles; Indoles; Insulin; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyridines; Receptors, Purinergic P1; Virulence Factors, Bordetella; Wortmannin; Xanthines	2000
Thrombin induces NO release from cultured rat microglia via protein kinase C, mitogen-activated protein kinase, and NF-kappa B. The Journal of biological chemistry, 2000, Sep-29, Volume: 275, Issue:39 Topics: Acetylcysteine; Animals; Carbazoles; Cells, Cultured; Cerebral Cortex; Enzyme Induction; Flavonoids; Imidazoles; Indoles; Maleimides; Microglia; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Kinase C; Proteins; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, PAR-1; Receptors, Thrombin; Signal Transduction; Thrombin	2000
Protein kinase calpha but not p44/42 mitogen-activated protein kinase, p38, or c-Jun NH(2)-terminal kinase is required for intercellular adhesion molecule-1 expression mediated by interleukin-1beta: involvement of sequential activation of tyrosine kinase, Molecular pharmacology, 2000, Volume: 58, Issue:6 Topics: Bridged-Ring Compounds; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Fluorescent Antibody Technique; Gene Expression; Humans; I-kappa B Kinase; Imidazoles; Indoles; Intercellular Adhesion Molecule-1; Interleukin-1; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutation; Naphthalenes; NF-kappaB-Inducing Kinase; Norbornanes; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Kinase C-alpha; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Staurosporine; Thiocarbamates; Thiones; Tyrphostins	2000
Signaling mechanism underlying COX-2 induction by lysophosphatidylcholine. Biochemical and biophysical research communications, 2001, Volume: 281, Issue:5 Topics: Activating Transcription Factor 1; Animals; Cattle; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; DNA-Binding Proteins; Endothelium, Vascular; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Imidazoles; Indoles; Isoenzymes; Isoquinolines; Lysophosphatidylcholines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; RNA, Messenger; Sulfonamides; Transcription Factors; Up-Regulation	2001
Pharmacological comparison of LTB(4)-induced NADPH oxidase activation in adherent and non-adherent guinea-pig eosinophils. British journal of pharmacology, 2001, Volume: 134, Issue:4 Topics: Androstadienes; Animals; Antibodies; Carbazoles; CD18 Antigens; Cell Adhesion; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Eosinophils; Flavonoids; Guinea Pigs; Imidazoles; Indoles; Integrin beta1; Intracellular Signaling Peptides and Proteins; Leukotriene B4; Macrophage-1 Antigen; Male; Maleimides; Mitogen-Activated Protein Kinases; NADPH Oxidases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein-Tyrosine Kinases; Pyrazoles; Pyridines; Pyrimidines; Rats; src-Family Kinases; Stilbenes; Syk Kinase; Time Factors; Wortmannin	2001
PKC- and ERK-dependent activation of I kappa B kinase by lipopolysaccharide in macrophages: enhancement by P2Y receptor-mediated CaMK activation. British journal of pharmacology, 2001, Volume: 134, Issue:5 Topics: Animals; Benzylamines; Bridged-Ring Compounds; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Enzyme Inhibitors; Flavonoids; I-kappa B Kinase; I-kappa B Proteins; Imidazoles; Indoles; Lipopolysaccharides; Macrophages; Macrophages, Peritoneal; Mitogen-Activated Protein Kinases; NF-kappa B; Norbornanes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Receptors, Purinergic P2; Sulfonamides; Thapsigargin; Thiocarbamates; Thiones; Time Factors; Transcription Factor RelA; Uridine Triphosphate	2001
Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells. Oncogene, 2001, Dec-06, Volume: 20, Issue:56 Topics: Breast Neoplasms; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Indoles; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Models, Biological; Neoplasm Invasiveness; Neuregulin-1; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Pyridines; RNA, Neoplasm; Signal Transduction; Transcriptional Activation; Tumor Cells, Cultured	2001
Phorbol esters inhibit fibroblast growth factor-2-stimulated fibroblast proliferation by a p38 MAP kinase dependent pathway. Oncogene, 2002, Mar-27, Volume: 21, Issue:13 Topics: 3T3 Cells; Animals; Cell Division; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblast Growth Factor 2; Fibroblasts; Flavonoids; Imidazoles; Indoles; Isoenzymes; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Pyridines; Tetradecanoylphorbol Acetate; Time Factors	2002
Thrombin rapidly induces protein kinase D phosphorylation, and protein kinase C delta mediates the activation. The Journal of biological chemistry, 2003, Jan-31, Volume: 278, Issue:5 Topics: Acetophenones; Animals; Aorta; Benzopyrans; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Indoles; Kinetics; Maleimides; Muscle, Smooth, Vascular; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Pyridines; Rats; Thrombin	2003
Interleukin-1beta induces MUC2 gene expression and mucin secretion via activation of PKC-MEK/ERK, and PI3K in human airway epithelial cells. Journal of Korean medical science, 2002, Volume: 17, Issue:6 Topics: Cell Line; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epithelium; Flavonoids; Humans; Imidazoles; Immunoassay; Immunoblotting; Indoles; Interleukin-1; Lung; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Morpholines; Mucin-2; Mucins; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein Structure, Tertiary; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors	2002
Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes. Circulation research, 2003, Aug-22, Volume: 93, Issue:4 Topics: Antioxidants; Cells, Cultured; Chemokine CCL2; Chromans; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genistein; Homocysteine; Humans; Imidazoles; Indoles; Interleukin-8; Monocytes; Naphthalenes; Onium Compounds; Pyridines; Pyrrolidines; Reactive Oxygen Species; RNA, Messenger; Sulfonamides; Thiazoles; Thiazolidinediones; Thiocarbamates; Time Factors; Troglitazone; Tyrphostins	2003
Endothelial NADPH oxidase: mechanism of activation by low-density lipoprotein. Endothelium : journal of endothelial cell research, 2003, Volume: 10, Issue:6 Topics: Arachidonic Acids; Cells, Cultured; Chromones; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Humans; Imidazoles; Indoles; Lipoproteins, LDL; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Morpholines; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phospholipases A; Protein Kinase C; Pyridines; Pyrrolidinones; Reactive Oxygen Species; Signal Transduction; src-Family Kinases; Type C Phospholipases; Umbilical Veins	2003
Inhibition of CREB transcriptional activity in human T lymphocytes by oxidative stress. Free radical biology & medicine, 2005, Jun-15, Volume: 38, Issue:12 Topics: Amino Acid Sequence; CD28 Antigens; CD3 Complex; Cyclic AMP Response Element-Binding Protein; Down-Regulation; Humans; Hydrogen Peroxide; Imidazoles; Indoles; Jurkat Cells; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Antigen, T-Cell; Ribosomal Protein S6 Kinases, 90-kDa; Serine; T-Lymphocytes; Transcription Factors; Transcription, Genetic	2005
Interleukin-10 inhibits lipopolysaccharide-induced survival and extracellular signal-regulated kinase activation in human neutrophils. European journal of immunology, 2005, Volume: 35, Issue:9 Topics: Apoptosis; Blotting, Western; Chromones; Drug Interactions; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Flow Cytometry; Humans; Imidazoles; Indoles; Interleukin-10; Lipopolysaccharides; Morpholines; Neutrophils; NF-kappa B; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Kinase Inhibitors; Pyridines	2005
The p38 mitogen-activated protein kinase pathway plays a critical role in PAR2-induced endothelial IL-8 production and leukocyte adhesion. Shock (Augusta, Ga.), 2008, Volume: 30, Issue:5 Topics: Activating Transcription Factors; Blotting, Western; Cell Adhesion; Cells, Cultured; DNA, Complementary; Flavonoids; Flow Cytometry; Humans; Imidazoles; Indoles; Integrin alpha4beta1; Intercellular Adhesion Molecule-1; Interleukin-8; Leukocytes; Lymphocyte Function-Associated Antigen-1; Macrophage-1 Antigen; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptor, PAR-2; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Trypsin; Vascular Cell Adhesion Molecule-1	2008
The ceramide-1-phosphate analogue PCERA-1 modulates tumour necrosis factor-alpha and interleukin-10 production in macrophages via the cAMP-PKA-CREB pathway in a GTP-dependent manner. Immunology, 2010, Volume: 129, Issue:3 Topics: Adenylyl Cyclases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bucladesine; Calcium Signaling; Cell Line; Cell Membrane; Ceramides; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Enzyme Inhibitors; Genes, Reporter; Guanosine Triphosphate; Imidazoles; Indoles; Interleukin-10; Isoquinolines; Lipopolysaccharides; Macrophages; Mice; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Response Elements; Ribosomal Protein S6 Kinases, 90-kDa; Rolipram; Signal Transduction; Sulfonamides; Transfection; Tumor Necrosis Factor-alpha	2010