Page last updated: 2024-09-05

sb 203580 and quercetin

sb 203580 has been researched along with quercetin in 14 studies

Compound Research Comparison

Studies
(sb 203580)
Trials
(sb 203580)
Recent Studies (post-2010)
(sb 203580)
Studies
(quercetin)
Trials
(quercetin)
Recent Studies (post-2010) (quercetin)
3,48941,13712,4032397,510

Protein Interaction Comparison

ProteinTaxonomysb 203580 (IC50)quercetin (IC50)
Neuraminidase Influenza A virus (A/Wilson-Smith/1933(H1N1))2.2
hexokinaseTrypanosoma brucei brucei TREU92722.378
Maltase-glucoamylase, intestinalHomo sapiens (human)7.8
NUAK family SNF1-like kinase 1Homo sapiens (human)5.09
Lysine-specific histone demethylase 1AHomo sapiens (human)1.26
B2 bradykinin receptorCavia porcellus (domestic guinea pig)4
Arginase Leishmania amazonensis4
Epidermal growth factor receptorHomo sapiens (human)0.9
ProthrombinHomo sapiens (human)1.5
Cationic trypsinBos taurus (cattle)7.1
Beta-lactamaseEscherichia coli K-124
NeuraminidaseInfluenza A virus (A/Puerto Rico/8/1934(H1N1))7.75
Interstitial collagenaseHomo sapiens (human)1.49
Phospholipase A2Homo sapiens (human)2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1Oryctolagus cuniculus (rabbit)9
Cytochrome P450 1A1Homo sapiens (human)5.5455
Amyloid-beta precursor proteinHomo sapiens (human)7.94
MyeloperoxidaseHomo sapiens (human)1.6975
Cytochrome P450 1A2Homo sapiens (human)4.097
Cyclin-dependent kinase 1Homo sapiens (human)0.45
Glycogen phosphorylase, liver formHomo sapiens (human)4.8
Epoxide hydrolase 1 Homo sapiens (human)7
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)6.6417
Insulin-like growth factor 1 receptorHomo sapiens (human)0.3
Neutrophil elastaseHomo sapiens (human)22.378
72 kDa type IV collagenaseHomo sapiens (human)6.68
Stromelysin-1Homo sapiens (human)5.57
Hepatocyte growth factor receptorHomo sapiens (human)0.58
Cytochrome P450 3A4Homo sapiens (human)7
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)2.6975
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus8.1
Lysosomal alpha-glucosidaseHomo sapiens (human)7.8
SialidaseClostridium perfringens4.7333
Malate dehydrogenaseThermus thermophilus6
Cytochrome P450 2C8Homo sapiens (human)7
Serine/threonine-protein kinase pim-1Homo sapiens (human)0.7686
AromataseHomo sapiens (human)0.012
Polyunsaturated fatty acid 5-lipoxygenaseRattus norvegicus (Norway rat)1.95
Polyunsaturated fatty acid lipoxygenase ALOX15Oryctolagus cuniculus (rabbit)0.43
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)0.12
Sucrase-isomaltase, intestinalHomo sapiens (human)7.8
Matrix metalloproteinase-9Homo sapiens (human)0.8919
Serine/threonine-protein kinase B-rafHomo sapiens (human)7.589
Aldo-keto reductase family 1 member B1Homo sapiens (human)2.2141
G2/mitotic-specific cyclin-BMarthasterias glacialis (spiny starfish)2.1
Polyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)2.2
Aldo-keto reductase family 1 member B1Bos taurus (cattle)2.85
Polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)0.44
Glycogen synthase kinase-3 betaRattus norvegicus (Norway rat)2.1
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)4
Casein kinase II subunit alpha'Homo sapiens (human)1.65
Amine oxidase [flavin-containing] AHomo sapiens (human)2.62
Amine oxidase [flavin-containing] A Bos taurus (cattle)0.01
C-X-C chemokine receptor type 1Homo sapiens (human)4.7559
Dipeptidyl peptidase 4Homo sapiens (human)2.92
Phosphatidylinositol 3-kinase regulatory subunit alphaHomo sapiens (human)3.8
Proteasome subunit beta type-5Homo sapiens (human)2.75
Vasopressin V2 receptorHomo sapiens (human)6.6548
Tyrosine-protein kinase receptor UFOHomo sapiens (human)0.96
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)1
RAC-alpha serine/threonine-protein kinaseHomo sapiens (human)5.39
Bifunctional epoxide hydrolase 2Homo sapiens (human)7
Vascular endothelial growth factor receptor 2Homo sapiens (human)0.97
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)0.59
17-beta-hydroxysteroid dehydrogenase type 2Homo sapiens (human)1.54
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)1
Collagenase 3Homo sapiens (human)8.46
1-deoxy-D-xylulose 5-phosphate reductoisomeraseEscherichia coli K-121.9
Xanthine dehydrogenase/oxidaseHomo sapiens (human)3.04
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)3.8
Glycogen synthase kinase-3 alphaHomo sapiens (human)2.1
Glycogen synthase kinase-3 betaHomo sapiens (human)2.1
Aldo-keto reductase family 1 member A1Rattus norvegicus (Norway rat)2.32
C-C chemokine receptor type 4Homo sapiens (human)10
Serine/threonine-protein kinase Nek2Homo sapiens (human)5.73
Serine/threonine-protein kinase PLK1Homo sapiens (human)5.75
Death-associated protein kinase 1Homo sapiens (human)8.9
Mitogen-activated protein kinase 10Homo sapiens (human)2.88
Beta-secretase 1Homo sapiens (human)6.05
Casein kinase II subunit betaHomo sapiens (human)1.65
Casein kinase II subunit alphaHomo sapiens (human)1.65
LactoperoxidaseBos taurus (cattle)6.1
Cyclin-dependent kinase 6Homo sapiens (human)2.1
Cyclin-dependent-like kinase 5 Homo sapiens (human)2.1
Cyclin homologHerpesvirus saimiri (strain 11)2.1
Lactoylglutathione lyaseHomo sapiens (human)3.2
Focal adhesion kinase 1Homo sapiens (human)1.2
Calcium/calmodulin-dependent protein kinase type II subunit betaHomo sapiens (human)3
ELAV-like protein 3Homo sapiens (human)1.8
Cyclin-dependent kinase 5 activator 1Homo sapiens (human)2.1
ELAV-like protein 1Homo sapiens (human)1.4
Serine/threonine-protein kinase N1Homo sapiens (human)5.8
Mitogen-activated protein kinase 14Homo sapiens (human)2.88
Cytochrome P450 1B1Homo sapiens (human)1.1108
Probable maltase-glucoamylase 2Homo sapiens (human)7.8
Monocarboxylate transporter 2Rattus norvegicus (Norway rat)5
Integrase Human immunodeficiency virus 14.3
Casein kinase II subunit alpha 3Homo sapiens (human)0.55
Inositol polyphosphate multikinaseHomo sapiens (human)2.3
Aldo-keto reductase family 1 member C21Mus musculus (house mouse)6.9
Enoyl-acyl-carrier protein reductase Plasmodium falciparum (malaria parasite P. falciparum)1.8333
3-oxoacyl-acyl-carrier protein reductase Plasmodium falciparum (malaria parasite P. falciparum)5.4
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)Plasmodium falciparum (malaria parasite P. falciparum)1.5
Aurora kinase BHomo sapiens (human)2.435
Cyclin-dependent kinase 1Oryzias latipes (Japanese medaka)2.1
Serine/threonine-protein kinase Nek6Homo sapiens (human)4.23
NADPH oxidase 4Homo sapiens (human)0.68
Inositol hexakisphosphate kinase 2Homo sapiens (human)0.7
Short transient receptor potential channel 5Homo sapiens (human)6.5
ALK tyrosine kinase receptorHomo sapiens (human)3.32
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)7.25

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (50.00)29.6817
2010's7 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Caivano, M; Cohen, P; Davies, SP; Reddy, H1
McGovern, SL; Shoichet, BK1
Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Ishikawa, Y; Kitamura, M1
Koop, DR; Wadsworth, TL1
Kanbach, K; Pekrun, A; Roth, C; Schulze, S; Witt, O1
Cao, J; Cetrulo, CL; Kandere-Grzybowska, K; Kempuraj, D; Theoharides, TC1
Li, L; Li, QJ; Li, WB; Sun, XC; Xian, XH; Yan, CZ; Zhang, M1
Chang, YC; Ho, YC; Lee, SS; Tsai, CH; Yu, CC1
Du, M; Gao, C; Li, Y; Liu, L; Shi, Y; Tang, Y; Xing, M; Xiong, T; Yao, P1
Kim, GT; Kim, JI; Kim, YM; Lee, SH1
Ha, KT; Kim, BJ; Kim, MC; Kim, SY; Lee, HJ; Lim, B; So, I1
Cho, SK; Jeong, KJ; Kim, S; Park, JW; Park, WJ1

Other Studies

14 other study(ies) available for sb 203580 and quercetin

ArticleYear
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
    The Biochemical journal, 2000, Oct-01, Volume: 351, Issue:Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides

2000
Kinase inhibitors: not just for kinases anymore.
    Journal of medicinal chemistry, 2003, Apr-10, Volume: 46, Issue:8

    Topics: beta-Lactamase Inhibitors; beta-Lactamases; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Biological; Phosphotransferases; Scattering, Radiation

2003
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-18, Volume: 104, Issue:51

    Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

2007
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
Anti-apoptotic effect of quercetin: intervention in the JNK- and ERK-mediated apoptotic pathways.
    Kidney international, 2000, Volume: 58, Issue:3

    Topics: Animals; Apoptosis; Cells, Cultured; Curcumin; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Glomerular Mesangium; Hydrogen Peroxide; Imidazoles; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; Mutagenesis; Oxidants; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyridines; Quercetin; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription Factor AP-1; Transfection

2000
Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced release of nitric oxide.
    Chemico-biological interactions, 2001, Jul-31, Volume: 137, Issue:1

    Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Ginkgo biloba; Imidazoles; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroprusside; Plant Extracts; Pyridines; Quercetin; Tumor Necrosis Factor-alpha

2001
Tumor cell differentiation by butyrate and environmental stress.
    Cancer letters, 2001, Oct-10, Volume: 171, Issue:2

    Topics: Butyrates; Cell Differentiation; Enzyme Inhibitors; HL-60 Cells; Hot Temperature; HT29 Cells; Humans; Imidazoles; K562 Cells; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Osmolar Concentration; p38 Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Pyridines; Quercetin; Tumor Cells, Cultured

2001
Regulation of IL-1-induced selective IL-6 release from human mast cells and inhibition by quercetin.
    British journal of pharmacology, 2006, Volume: 148, Issue:2

    Topics: Carbazoles; Cell Line, Tumor; Cells, Cultured; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Humans; Imidazoles; Indoles; Interleukin-1; Interleukin-6; Isoenzymes; Mast Cells; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; Quercetin

2006
Activation of p38 MAPK participates in brain ischemic tolerance induced by limb ischemic preconditioning by up-regulating HSP 70.
    Experimental neurology, 2010, Volume: 224, Issue:2

    Topics: Animals; Blotting, Western; Brain Ischemia; CA1 Region, Hippocampal; Disease Susceptibility; Enzyme Activation; Hindlimb; HSP70 Heat-Shock Proteins; Imidazoles; Immunohistochemistry; Ischemic Preconditioning; Male; p38 Mitogen-Activated Protein Kinases; Pyridines; Quercetin; Rats; Rats, Wistar; Up-Regulation

2010
Heat shock protein 27 expression in areca quid chewing-associated oral squamous cell carcinomas.
    Oral diseases, 2012, Volume: 18, Issue:7

    Topics: Acetylcysteine; Areca; Arecoline; Carcinoma, Squamous Cell; Case-Control Studies; Catechin; Cyclooxygenase 2 Inhibitors; Down-Regulation; Female; Flavonoids; Gene Expression; Gene Expression Regulation, Neoplastic; HSP27 Heat-Shock Proteins; Humans; Imidazoles; Male; Middle Aged; Mouth Neoplasms; Nitrobenzenes; Pyridines; Quercetin; Sulfonamides

2012
Carbon monoxide alleviates ethanol-induced oxidative damage and inflammatory stress through activating p38 MAPK pathway.
    Toxicology and applied pharmacology, 2013, Nov-15, Volume: 273, Issue:1

    Topics: Alanine Transaminase; Animals; Anthracenes; Aspartate Aminotransferases; Carbon Monoxide; Ethanol; Flavonoids; Glutathione; Heme Oxygenase-1; Hepatocytes; Imidazoles; Interleukin-6; L-Lactate Dehydrogenase; Liver Diseases, Alcoholic; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Organometallic Compounds; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phytochemicals; Pyridines; Quercetin; Rats; Tumor Necrosis Factor-alpha

2013
Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner.
    International journal of molecular medicine, 2014, Volume: 33, Issue:4

    Topics: Acetylcysteine; AMP-Activated Protein Kinases; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enzyme Activation; Humans; Imidazoles; Intracellular Space; MAP Kinase Signaling System; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Pyridines; Quercetin; Reactive Oxygen Species; RNA, Small Interfering; Toluene; Transfection; Tumor Suppressor Protein p53

2014
Quercetin induces apoptosis by inhibiting MAPKs and TRPM7 channels in AGS cells.
    International journal of molecular medicine, 2014, Volume: 33, Issue:6

    Topics: Anthracenes; Apoptosis; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Flavonoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Quercetin; TRPM Cation Channels

2014
Caffeic acid, morin hydrate and quercetin partially attenuate sulfur mustard-induced cell death by inhibiting the lipoxygenase pathway.
    Molecular medicine reports, 2016, Volume: 14, Issue:5

    Topics: Antioxidants; Caffeic Acids; Cell Death; DNA Adducts; Flavonoids; Gene Expression Regulation; Imidazoles; Keratinocytes; Lipoxygenase; Mustard Gas; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Quercetin; Reactive Oxygen Species; Signal Transduction; Tumor Suppressor Protein p53

2016