sb 203580 has been researched along with pyrazolanthrone in 314 studies
| Studies (sb 203580) | Trials (sb 203580) | Recent Studies (post-2010) (sb 203580) | Studies (pyrazolanthrone) | Trials (pyrazolanthrone) | Recent Studies (post-2010) (pyrazolanthrone) |
|---|---|---|---|---|---|
| 3,489 | 4 | 1,137 | 1,484 | 2 | 765 |
| Protein | Taxonomy | sb 203580 (IC50) | pyrazolanthrone (IC50) |
|---|---|---|---|
| Chain A, Mitogen-activated protein kinase 10 | Homo sapiens (human) | 0.15 | |
| Chain A, Mitogen-activated protein kinase 10 | Homo sapiens (human) | 0.15 | |
| Chain A, Mitogen-activated protein kinase 10 | Homo sapiens (human) | 0.15 | |
| TPA: protein transporter TIM10 | Saccharomyces cerevisiae S288C | 20.2 | |
| TPA: protein transporter TIM23 | Saccharomyces cerevisiae S288C | 6.31 | |
| Serine/threonine-protein kinase/endoribonuclease IRE1 | Homo sapiens (human) | 0.72 | |
| Interferon-induced, double-stranded RNA-activated protein kinase | Homo sapiens (human) | 8 | |
| Dual specificity protein kinase TTK | Homo sapiens (human) | 0.8987 | |
| Mitogen-activated protein kinase 8 | Homo sapiens (human) | 0.921 | |
| Mitogen-activated protein kinase 9 | Homo sapiens (human) | 1.0111 | |
| Tyrosine-protein kinase JAK3 | Homo sapiens (human) | 0.957 | |
| Mitogen-activated protein kinase 10 | Homo sapiens (human) | 1.4193 | |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | 0.15 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 156 (49.68) | 29.6817 |
| 2010's | 149 (47.45) | 24.3611 |
| 2020's | 9 (2.87) | 2.80 |
| Authors | Studies |
|---|---|
| Atteridge, CE; Azimioara, MD; Benedetti, MG; Biggs, WH; Carter, TA; Ciceri, P; Edeen, PT; Fabian, MA; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lélias, JM; Lockhart, DJ; Mehta, SA; Milanov, ZV; Patel, HK; Treiber, DK; Velasco, AM; Wodicka, LM; Zarrinkar, PP | 1 |
| Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N | 1 |
| Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M | 1 |
| Hajduk, PJ; Johnson, EF; Kifle, L; Merta, PJ; Metz, JT; Soni, NB | 1 |
| Akao, Y; Fujita, Y; Hamada, N; Ito, M; Itoh, T; Kiso, Y; Kitagawa, Y; Nozawa, Y; Ono, Y; Tanaka, A; Tomimori, N | 1 |
| Kato, E; Sasaki, Y; Takahashi, N | 1 |
| Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A | 1 |
| Chang, J; Liu, XH; Sun, X; Yu, JM; Zhong, C | 1 |
| Caballero, E; García-Cárceles, J; Gil, C; Martínez, A | 1 |
| Chokchaisiri, R; Chuprajob, T; Lin, Y; Lu, X; Shen, X; Sornkaew, N; Suksamrarn, A; Wang, F; Wang, P; Wongkrajang, K; Yang, L; Yang, N; Zhang, G; Zhou, Z | 1 |
| Bennett, BL; Bradham, CA; Brenner, DA; Manning, AM; Schnabl, B; Stefanovic, B | 1 |
| Hirade, K; Kozawa, O; Tokuda, H; Wang, X | 1 |
| Jiang, Y; Liu, A; Qin, Q; Yin, Z | 1 |
| Costanzo, FS; Cuda, G; Fratto, D; Grembiale, RD; Marsico, SA; Maselli, R; Pelaia, G; Tagliaferri, P; Vatrella, A | 1 |
| Iwasaka, T; Maeda, A; Nishikawa, M; Toyoda, N; Yasuzawa-Amano, S | 1 |
| Hirade, K; Kozawa, O; Oiso, Y; Tokuda, H; Wang, X | 1 |
| Dobashi, K; Ishizuka, T; Masubuchi, K; Mori, M; Nakazawa, T; Shimizu, Y; Utsugi, M | 1 |
| Aiso, S; Chiba, T; Hashimoto, Y; Ichijo, H; Ishizaka, M; Kadowaki, H; Nawa, M; Niikura, T; Nishimoto, I; Nishitoh, H; Terashita, K; Tsukamoto, E; Yamada, M; Yamagishi, Y | 1 |
| Dobashi, K; Endou, K; Hamuro, J; Ishizuka, T; Mori, M; Murata, Y; Nakazawa, T; Utsugi, M | 1 |
| Jambal, P; Pugazhenthi, S; Reusch, JE; Vaishnav, D | 1 |
| Joo, YH; Kim, DS; Kim, SY; Kwon, SB; Lee, JE; Park, KC; Youn, SW | 1 |
| Genade, S; Hattingh, S; Huisamen, B; Lochner, A; Marais, E; Moolman, JA | 1 |
| Coppens, A; Hooghe-Peters, E; Kooijman, R | 1 |
| Fukuda, I; Hatakeyama, M; Imaizumi, T; Matsumiya, T; Munakata, H; Satoh, K; Shibata, T; Tamo, W; Yoshida, H | 1 |
| Cameron, P; Giembycz, MA; Plevin, R; Rotondo, D; Smith, SJ | 1 |
| Iovanna, JL; Lesavre, N; Malicet, C; Vasseur, S | 1 |
| Du, Y; Lin, S; Paul, SM; Wei, X; Yan, C | 1 |
| Greene, SM; Headley, VV; Port, JD; Tanveer, R; Zweifach, A | 1 |
| Dent, P; Grant, S; Rahmani, M; Yu, C | 1 |
| Ingelfinger, JR; Moini, B; Zhang, SL | 1 |
| Ishisaki, A; Kanno, Y; Kozawa, O; Nakajima, K; Numata, O; Shibata, T; Tokuda, H | 1 |
| Ariga, H; Matsumoto, K; Minamitani, T; Orba, Y; Sato, M; Sawa, H | 1 |
| Allen, WE; Campbell, M; Sawyer, C; Trimble, ER; Vanhaesebroeck, B | 1 |
| Aikin, R; Maysinger, D; Rosenberg, L | 1 |
| Basta-Kaim, A; Budziszewska, B; Jaworska-Feil, L; Kubera, M; Lasoń, W; Leśkiewicz, M; Tetich, M | 1 |
| Kawashima, K; Nakajima, M; Negishi, Y; Tanaka, H | 1 |
| Campbell, FC; Collett, GP | 1 |
| Alexander, M; Chaudry, IH; Daniel, T; Schwacha, MG | 1 |
| Adner, M; Bryborn, M; Cardell, LO | 1 |
| Matlis, S; Mooney, DJ; Nikolovski, J; Simmons, CA; Thornton, AJ | 1 |
| Chiou, WF; Tsai, HR; Tsai, WJ; Yang, LM | 1 |
| Chen, Q; Furue, M; Moroi, Y; Nakahara, T; Uchi, H; Urabe, K | 1 |
| Chalothorn, D; Faber, JE; Jackson, LF; Lee, DC; Zhang, H | 1 |
| Endoh, D; Hamasu, T; Hayashi, M; Kawana, A; Matsumoto, M; Okui, T | 1 |
| Dai, Y; Fukuoka, T; Katsura, H; Kobayashi, K; Mizushima, T; Noguchi, K; Obata, K; Tokunaga, A; Yamanaka, H | 1 |
| Chen, JW; Chen, YH; Chen, YL; Hung, YY; Ku, HH; Lin, SJ; Shyue, SK; Tam, KB | 1 |
| Barger, SW; Bodles, AM | 1 |
| Islam, Z; Pestka, JJ; Uzarski, RL | 1 |
| Boislève, F; Kerdine-Römer, S; Pallardy, M | 1 |
| Li, X; Tang, J; Zhang, M | 1 |
| Jung, YS; Kim, E; Lee, DH; Lim, H; Yi, KY; Yoo, SE | 1 |
| Chang, WL; Chen, YL; Cheng, YL; Harn, HJ; Lin, SZ | 1 |
| Cheung, PF; Ip, WK; Lam, CW; Wong, CK | 1 |
| Fukuda, Y; Goto, M; Hayashi, Y; Oikawa, S; Terakawa, M; Tomimori, Y | 1 |
| Chang, YC; Hsu, JD; Huang, HP; Wang, CJ; Yang, SF | 1 |
| Chen, HY; Cui, RY; Du, W; Han, ZW; Wang, CB; Wang, YJ; Zhan, SM; Zhu, L | 1 |
| Allshire, A; Anoopkumar-Dukie, S; Carey, JB; Conere, T | 1 |
| Bertelsen, M; Sanfridson, A | 1 |
| Chan, G; Das, S; Guilbert, LJ; Johnstone, ED; Lowen, B; Mackova, M; Payne, SG; Sibley, CP | 1 |
| Alvarez, S; Fresno, M; Muñoz-Fernández, M; Serramía, MJ | 1 |
| Wu, XY; Yu, FS; Zhang, J | 1 |
| Chansard, M; Fukuhara, C; Iwahana, E; Liang, J | 1 |
| Lim, RW; Park, PH; Shukla, SD | 1 |
| Choi, JW; Choi, MS; Jeon, MJ; Ko, KH; Park, GH; Ryu, MK; Yoo, oK | 1 |
| Altieri, P; Ballestrero, A; Barisione, C; Barsotti, A; Brunelli, C; Fabbi, P; Garibaldi, S; Ghigliotti, G; Manca, V; Spallarossa, P | 1 |
| Goldring, MB; Jalonen, U; Kankaanranta, H; Lahti, A; Leinonen, S; Moilanen, E; Nieminen, R; Vuolteenaho, K | 1 |
| Cherla, RP; Lee, SY; Mees, PL; Tesh, VL | 1 |
| Laham, R; Li, J; Luo, J; Rana, JS; Sellke, FW; Wu, G | 1 |
| Akita, Y; Enoki, C; Fujiwara, H; Imamura, H; Iwasaka, T; Kamihata, H; Kyoi, S; Matsuhisa, S; Otani, H; Tatsumi, K | 1 |
| Ikejima, T; Li, LH; Onodera, S; Tashiro, SI; Uchiumi, F; Wu, LJ | 1 |
| Chang, SH; Chen, LM; Hsu, HH; Huang, CY; Hwang, JM; Kuo, WW; Lee, SD; Lin, JA; Lu, MC; Wang, CK; Wu, CC | 1 |
| Chayama, K; Kuwahara, K; Miyata, H; Sasaki, T; Serikawa, M | 1 |
| Yao, XX; Zhang, YP; Zhao, X | 1 |
| Lim, IJ; Longaker, MT; Phan, TT; Xia, W; Yang, GP | 1 |
| Bhat, NR; Shen, Q; Zhang, R | 1 |
| Abe, M; Funaba, M; Ikeda, T; Murakami, M; Nishino, Y; Ogawa, K; Sugino, H; Tsuchida, K | 1 |
| Bouillon, R; Mathieu, C; Overbergh, L; Stoffels, K; Verstuyf, A; Waer, M | 1 |
| Lu, Q; Qiu, TQ; Yang, H | 1 |
| Dong, YG; Li, HL; Yin, R | 1 |
| Chen, HK; Chen, SL; Cheng, HC; Ho, TC; Tsao, YP; Wu, AC; Yang, YC | 1 |
| Cheon, JM; Huh, S; Hwang, CH; Hyun, CG; Jung, E; Kim, EJ; Kim, YS; Lee, HY; Lee, J; Park, D | 1 |
| Hirasawa, N; Murakami, A; Ohgawara, R; Ohuchi, K; Torigoe, M | 1 |
| Aller, P; Fernández, C; Fraile, B; García-Tuñón, I; Paniagua, R; Ricote, M; Royuela, M | 1 |
| Barbetti, V; Dello Sbarba, P; Giuntoli, S; Gozzini, A; Rovida, E; Santini, V | 1 |
| Ashizuka, M; Ito, S; Kubota, Y; Ogata, S; Satoh, S; Shirasuna, K; Takeuchi, H | 1 |
| Goto, T; Iwashita, K; Maeda-Nakamura, K; Nagashima, H | 1 |
| Nam, SI | 1 |
| Clough, RL; Stefanis, L | 1 |
| Fisher, RA; Samuel, I; Zaheer, A | 1 |
| Acín, S; Amador, P; de la Osada, J; García-Herrera, J; Lostao, MP; Marca, MC; Navarro, MA; Rodríguez-Yoldi, MJ; Salvador, MT | 1 |
| Hakariya, T; Igawa, T; Kanetake, H; Sakai, H; Shida, Y | 1 |
| Aranbayeva, Z; Dickinson, D; Digumarthi, H; Hsu, S; Lewis, J; Messer, R; Osaki, T; Qin, H; Schuster, GS; Wataha, J; Yamamoto, T | 1 |
| Chen, JW; Chen, YH; Chen, YL; Hsieh, LY; Ku, HH; Lin, CY; Lin, FY; Lin, SJ; Wang, SH; Wang, YC | 1 |
| Fuhrmann, R; Gandesiri, M; Kinne, RW; Kunisch, E; Roth, A; Winter, R | 1 |
| Aizu-Yokota, E; Kasahara, T; Murakami, Y; Ohta, S; Sonoda, Y | 1 |
| Chen, JH; Huang, CC; Lin, HH; Wang, CJ | 1 |
| Chen, YP; Luo, Y; Rui, HL | 1 |
| Hanai, Y; Harada, A; Hosoi, T; Kozawa, O; Matsushima-Nishiwaki, R; Ohta, T; Takai, S; Tokuda, H | 1 |
| Han, J; Jeong, YI; Jung, ID; Lee, CM; Lee, JS; Park, WS; Park, YM | 1 |
| Chang, WJ; Chen, LW; Chen, PH; Hsu, CM; Karin, M; Wang, JS | 1 |
| Kuo, YR; Wang, FS; Wu, WS | 1 |
| Choi, SE; Jang, HJ; Kang, Y; Kim, DJ; Kim, HE; Kim, HJ; Kim, HS; Lee, KW; Shin, HC | 1 |
| Booth, JL; Chakrabarty, K; Coggeshall, KM; Duggan, ES; Metcalf, JP; Nagle, NN; Wu, W | 1 |
| Bach, LA; Fu, P; Thompson, JA | 1 |
| Belsey, MJ; Davies, AR; Kozlowski, RZ; Witchel, HJ | 1 |
| Choi, YH; Kim, GY; Lee, KJ; Moon, DO | 1 |
| Lee, YJ; Shukla, SD | 1 |
| Hsu, SP; Huang, CN; Peng, CH; Wang, CJ | 1 |
| Chang, PM; Chen, WC; Chou, CT; Chu, ST; Fang, YC; Huang, CC; Huang, CJ; Jan, CR; Liu, SI; Lu, YC; Wang, BW; Wang, JL | 1 |
| Barnett, J; Chain, BM; Handley, ME; Katz, DR; Pollara, G; Rasaiyaah, J; Thakker, M | 1 |
| Bei, JX; Chen, JL; Feng, LN; Lin, HR; Liu, XC; Lu, DQ; Wang, L; Zhang, Y | 1 |
| Liu, YC; Pan, YS; Rong, L; Tang, JQ; Wan, YL; Wang, X; Wu, T; Zhu, J | 1 |
| Berger, F; Champelovier, P; El Atifi, M; Pautre, V; Rostaing, B; Seigneurin, D | 1 |
| Cui, Q; Ikejima, T; Minami, M; Onodera, S; Tashiro, S | 1 |
| Cederbaum, A; Wu, D | 1 |
| Deng, Z; Qiu, H; Wu, Y; You, X; Yu, M; Zeng, Y | 1 |
| Alexis, NE; Bromberg, PA; Chen, X; Peden, DB; Wu, W | 1 |
| Nomura, M; Nomura, N; Sugiyama, K; Takahira, M | 1 |
| Baizabal-Aguirre, VM; Barriga-Rivera, JG; Bravo-Patiño, A; Cajero-Juárez, M; Cárabez-Trejo, A; Oviedo-Boyso, J; Valdez-Alarcón, JJ | 1 |
| Ciarcia, R; D'Isanto, M; Finamore, E; Galdiero, M; Kampanaraki, A; Vitiello, M | 1 |
| Bachelet, M; Bardin, S; Broquet, AH; Gasnereau, I; Jouniaux, AM; Lenoir, C; Masliah, J; Sapin, C; Seksik, P; Thomas, G; Trugnan, G | 1 |
| Fujita-Yoshigaki, J; Matsuki-Fukushima, M; Sugiya, H | 1 |
| Hagihara, K; Isobe, T; Kawase, I; Matsumura, A; Naka, T; Nishikawa, T; Serada, S; Song, J; Tanaka, T; Yoshizaki, K | 1 |
| Chi, CW; Lee, HC; Wang, SF; Yen, JC; Yin, PH | 1 |
| Chang, SP; Chao, KC; Chen, YH; Hsu, WL; Li, HY; Sung, YJ; Tsui, KH | 1 |
| Colvin, HP; Gerner, P; Haller, I; Klimaschewski, L; Lang, L; Lirk, P; Tomaselli, B | 1 |
| Graves, PR; Sankala, H; Zeng, Y; Zhang, X | 1 |
| Ogata, T | 1 |
| Choi, KH; Eo, SK; Kim, K; Kim, SM; Lee, KA; Moon, YS; Rhim, BY; Son, YH; Sung, SC | 1 |
| Deng, J; Feng, X; Geng, L; Jiang, G; Liu, J; Qian, Y; Wang, Y; Xie, H; Ye, Z; Yin, S; Zheng, S; Zhou, L | 1 |
| Bachleda, P; Dvorák, Z | 1 |
| Norlin, M; Pettersson, H; Tang, W | 1 |
| Alignani, DO; Gorlino, CV; Liscovsky, MV; Maletto, BA; Morón, G; Pistoresi-Palencia, MC; Ranocchia, RP | 1 |
| Morand, E; Santos, L; Yamana, J | 1 |
| Behren, A; Iftner, T; Mühlen, S; Plinkert, PK; Simon, C | 1 |
| Binion, DG; Floer, M; Manley, S; Nelson, VM; Rafiee, P; Shaker, R; Wellner, M | 1 |
| Katayama, T; Minami, M; Tanaka, H; Uehara, T; Yoshida, T | 1 |
| Diffley, JM; Hammad, SM; Lyons, TJ; Sohn, M; Song, W; Wu, M | 1 |
| Baizabal-Aguirre, VM; Bravo-Patiño, A; Cajero-Juárez, M; Oviedo-Boyso, J; Valdez-Alarcón, JJ | 1 |
| Graham, CH; Renaud, SJ; Sullivan, R | 1 |
| Hanada, K; Iwasaki, Y; Kageyama, K; Nigawara, T; Sakihara, S; Suda, T; Takayasu, S | 1 |
| Cohick, WS; Leibowitz, BJ | 1 |
| Bi, Z; Chen, W; Ji, C; Kang, J; Wan, Y; Yang, B | 1 |
| An, L; Han, Y; Li, W; Niu, M | 1 |
| Aarnes, H; Fonnum, F; Mariussen, E; Myhre, O; Reistad, T; Voie, OA | 1 |
| Bucio, L; Escobar, Mdel C; Gómez-Quiroz, LE; Gutiérrez Ruiz, MC; Hernández, E; Souza, V | 1 |
| Chen, HM; Cheng, SJ; Chiang, CP; Deng, YT; Kuo, MY | 1 |
| Hendricks, M; Jesuthasan, S | 1 |
| Duan, W; Jiang, G; Song, S; Wu, L; Xu, L; Zhu, C | 1 |
| Antonios, D; Gautier, JC; Lacour, S; Pallardy, M | 1 |
| Asano, S; Itoh, M; Nishiwaki-Yasuda, K; Sekiguchi, S; Shibata, M; Suzuki, A | 1 |
| Du, ZX; Gao, YY; Guan, Y; Liu, BQ; Meng, X; Wang, HQ; Zhang, HY | 1 |
| Kawanishi, M; Koizumi, K; Nishimura, M; Saiki, I; Sakurai, H; Shin, MS; Singhirunnusorn, P; Suzuki, S | 1 |
| Aylor, KW; Burger, LL; Haisenleder, DJ; Marshall, JC | 1 |
| Jeon, YT; Kim, SH; Kim, YB; Lee, SC; Song, YS | 1 |
| Aloi, C; Altieri, P; Barisione, C; Barsotti, A; Brunelli, C; Fugazza, G; Garibaldi, S; Ghigliotti, G; Spallarossa, P | 1 |
| Bulgheresi, S; Emami, C; Mittal, R; Prasadarao, NV | 1 |
| Chen, LM; Chen, YS; Fang, WK; Huang, CY; Ko, FY; Kuo, CH; Kuo, WW; Tsai, CH; Tsai, FJ; Wang, HL | 1 |
| Dai, SM; Qin, YH; Ren, D; Shen, Q; Tang, GS; Wang, ZW; Zhang, J | 1 |
| Arantes, C; Brentani, MM; da Costa, SV; Junqueira, MS; Roela, RA | 1 |
| Kim, HJ; Lee, WJ | 1 |
| Li, Q; Li, WM; Zhang, J; Zou, P | 1 |
| Kohsaka, S; Nakajima, K; Tohyama, Y; Yamamoto, S | 1 |
| Chang, JW; Han, NJ; Kim, YJ; Lee, JM; Park, SK; Yang, WS | 1 |
| Fan, M; He, Z; Jiang, H; Jiang, Q; Li, M; Liang, C; Liu, X; Pan, X; Ren, Y; Wu, J; Wu, Z | 1 |
| Herdegen, T; Klettner, A; Koinzer, S; Roider, J; Waetzig, V | 1 |
| Algood, HS; Asim, M; Barry, DP; Chaturvedi, R; de Sablet, T; Gobert, AP; Hoge, S; Lewis, ND; Singh, K; Wilson, KT | 1 |
| Cheng, ML; Cheng, TH; Chiu, DT; Ho, HY; Lin, CJ; You, TH; Yu, JS | 1 |
| Armstead, WM; Cines, DB; Higazi, AA; Kiessling, JW; Riley, J | 3 |
| Chen, DB; Feng, L; Liao, WX; Zheng, J | 1 |
| Hosokawa, I; Hosokawa, Y; Matsuo, T; Nakae, H; Ozaki, K; Yumoto, H | 1 |
| Bisch, SP; Haeryfar, SM; Hayatsu, J; Leon-Ponte, M; Maleki Vareki, S; Mazzuca, DM; Stuart, JK | 1 |
| Fukami, T; Mizuno, K; Nakajima, M; Toyoda, Y; Yokoi, T | 1 |
| Bolcome, RE; Chan, J | 1 |
| Agrawal, M; Bala Bhaskar, AS; Gupta, N; Lakshmana Rao, PV; Ravindran, J | 1 |
| Chen, H; Jin, WY; Ren, JY | 1 |
| Chen, XH; Han, YL; Kang, J; Liang, M; Qi, YM | 1 |
| Liu, H; Ruan, J; Wei, A; Xiao, Y; Xiong, C | 1 |
| Brunk, UT; Guo, X; He, F; Huang, Q; Pang, S; Wu, W; Xiao, M; Zhao, K; Zhao, M | 1 |
| Carr, M; Chavez-Muñoz, C; Ghahary, A; Lai, A | 1 |
| Andersen, DC; Christensen, GL; Eskildsen, T; Gammeltoft, S; Hansen, JL; Jensen, HB; Jeppesen, PL; Nossent, AY; Schneider, M; Sheikh, SP | 1 |
| Jeon, HW; Kim, WH; Lee, KJ; Lee, SH; Lee, YM | 1 |
| Chang, SP; Chen, YC; Lee, WR; Shen, SC; Yang, LL | 1 |
| Chang, KC; Jeong, YS; Kim, HJ; Kim, JG; Kwon, SC; Lee, SM; Ok, SH; Sohn, JT; Sung, HJ | 1 |
| Bhoopathi, P; Chetty, C; Gorantla, B; Kesanakurti, D; Lakka, SS; Rao, JS; Tsung, AJ | 1 |
| Huang, JL; Jiang, CL; Ma, Q; Shen, XH; Wang, CC; Wang, X; Zhang, YL; Zhou, JR | 1 |
| Liu, L; Xie, C | 1 |
| He, SZ; Jian, CX; Li, CJ; Liu, XC; Liu, XF | 1 |
| Chang, KC; Jun, MS; Kim, HJ; Kim, HS; Kim, YM; Kim, YS; Lee, JH; Lee, KR; Park, EJ | 1 |
| Halfmann, P; Kawaoka, Y; Neumann, G | 1 |
| Aso, H; Hasegawa, Y; Imaizumi, K; Ito, S; Kondo, M; Mori, A; Morioka, M; Suganuma, N | 1 |
| Yao, X; Zhang, Y | 1 |
| Jung, YD; Khoi, PN; Kim, NH; Park, JS | 1 |
| Bourque, SD; Khatchadourian, A; Maysinger, D; Richard, VR; Titorenko, VI | 1 |
| Chen, XM; Drescher, KM; Gong, AY; Hu, G; Li, X; Zhou, R | 1 |
| Chang, Y; Shi, L; Wu, X; Yang, Y; Yu, FS; Zhang, Y | 1 |
| He, W; Qu, T; Smith, AJ; Wang, H; Wang, Z; Yu, Q; Zhang, J | 1 |
| Chang, JZ; Chen, HM; Deng, YT; Kuo, MY; Yang, WH | 1 |
| Cherla, RP; Lee, MS; Leyva-Illades, D; Tesh, VL | 1 |
| Chung, J; Jeong, SY; Kim, JS; Kim, KD; Kim, S; Na, HS; Park, HR | 1 |
| Han, Y; Lei, L; Lu, S; Luo, G; Ning, Q; Wang, S; Yuan, X; Zhang, F | 1 |
| Chao, X; Chen, T; Fei, Z; Jiang, X; Li, D; Li, S; Liu, W; Lu, G; Luo, P; Poon, W; Qu, Y; Zhang, L; Zhao, Y | 1 |
| Peng, B; Wei, H; Wu, Y; Xing, X; Yang, S; Zhan, N; Zhu, L | 1 |
| Chang, CH; Chen, HT; Tang, CH; Tsou, HK; Yang, WY | 1 |
| Arruebo, MP; Gonzalo, S; Grasa, L; Hernández, LV; Murillo, MD; Plaza, MÁ | 1 |
| Chotjumlong, P; Chruewkamlow, N; Kasinrerk, W; Krisanaprakornkit, S; Pata, S; Reutrakul, V | 1 |
| Aligue, R; de Olano, N; Gomes, AR; Koo, CY; Lam, EW; Monteiro, LJ; Pinto, PH | 1 |
| Han, H; Lee, KS; Rong, W; Zhang, G | 1 |
| Ahmad, R; Chaudry, A; El Mabrouk, M; Sylvester, J; Zafarullah, M | 1 |
| Chen, M; Hu, DN; Li, SS; Yao, L | 1 |
| Hintze, TH; Huang, A; Kaley, G; Sun, D; Yan, C; Yang, YM | 1 |
| Hasegawa, Y; Okada, Y; Shimizu, T; Takahashi, N | 1 |
| Cao, M; Ji, F; Liang, J; Liu, F; Liu, L; Wang, T; Wu, Q | 1 |
| Lowe-Krentz, LJ; Slee, JB | 1 |
| Chen, CH; Chen, KL; Chen, SJ; Huang, CF; Hung, DZ; Jinn, TR; Lee, kI; Su, CC; Su, YC; Tang, FC; Tseng, TJ; Yen, CC | 1 |
| Demirel, I; Mohlin, C; Persson, K; Säve, S; Svensson, L; Vumma, R | 1 |
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| Qin, HP; Si, PP; Sun, P; Sun, XF; Yang, XR; Zhang, C | 1 |
| Hwangbo, C; Kim, N; Lee, JH; Lee, S | 1 |
| Cooper, PR; He, W; Huang, P; Smith, AJ; Wang, ZH; Yu, Q; Zhang, J; Zhu, QL | 1 |
| Akutsu, M; Ito, K; Kawashima, M; Kishida, T; Kondoh, T; Ogura, N | 1 |
| Chen, HH; Shi, YL; Yang, J; Zhou, XL | 1 |
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| Ou, SJ; Quinn, TM; Rosenzweig, DH | 1 |
| Alhosin, M; Anselm, E; Bronner, C; Kim, JH; Madeira, SV; Rashid, S; Schini-Kerth, VB | 1 |
| Sakamoto, N; Sato, M; Song, G; Yuan, L | 1 |
| Cheng, M; Li, M; Meng, W; She, T; Shi, C; Wang, B; Yu, L | 1 |
| Chenyang, J; Jiajing, W; Jianchun, B; Jianhong, G; Xuezhong, L; Yan, Y; Yiran, Z; Zongping, L | 1 |
| Chang, HH; Chang, JZ; Deng, YT; Kuo, MY; Liu, CM; Yang, WH | 1 |
| Da, L; Li-mei, X; Li-xia, L; Wei-dong, R; Ying, H; Yu, X; Yu-xiu, S | 1 |
| Choi, NK; Hwang, YC; Jung, JY; Kim, SH; Kim, SM; Kim, WJ; Lim, HS; Woo, SM | 1 |
| E, LL; Liang, L; Liu, H; Liu, N; Wang, DS; Yu, J; Zhou, W | 1 |
| Halder, S; Jesan, T; Saha, B; Sarma, U; Sinha, S | 1 |
| Billiar, TR; Fan, J; Fan, L; Jiang, Y; Li, S; Li, Y; Liu, Z; Scott, MJ; Wang, J; Wilson, MA; Xiao, G | 1 |
| Kim, SJ; Yu, SM | 1 |
| Jin, X; Sun, Y; Tang, SS; Wang, CC; Xiao, XL; Zhang, CM; Zhang, T; Zhao, WX | 1 |
| Hosokawa, I; Hosokawa, Y; Matsuo, T; Ozaki, K; Shindo, S | 1 |
| Chang, SL; Fong, YC; Hsu, CJ; Lin, CY; Tang, CH | 1 |
| Du, M; Gao, C; Li, Y; Liu, L; Shi, Y; Tang, Y; Xing, M; Xiong, T; Yao, P | 1 |
| Kikuchi, H; Takagi, N; Toyoda, H; Yuan, B; Yuhara, E | 1 |
| Hou, DJ; Jin, PS; Li, PH; Li, Q; Li, XY; Tao, CB; Zhang, AJ | 1 |
| Chen, J; Guo, R; Huang, R; Li, S; Tian, L; Wu, K; Yan, H; You, Q | 1 |
| Tang, N; Yao, XX; Ying, W; Zhang, YP | 1 |
| Jung, TY; Kim, JH; Kim, MG; Lee, S; Leem, KH; Lim, SC; Seo, J | 1 |
| Bu, HQ; Chen, L; Cui, JH; Huang, H; Li, Y; Liu, DL; Wei, WT | 1 |
| Gao, P; Si, LY; Song, S; Xiao, H; Xu, Y | 1 |
| Ha, KT; Kim, BJ; Kim, MC; Kim, SY; Lee, HJ; Lim, B; So, I | 1 |
| Chen, JY; Qin, LP; Su, L; Zhang, H; Zhang, L | 1 |
| Gweon, EJ; Kim, SJ | 1 |
| Baek, MW; Chung, HJ; Jeong, YJ; Jung, JY; Kim, GM; Kim, SH; Kim, WJ; Park, HJ; Seong, KJ | 1 |
| He, WX; Kim, S; Kohli, MR; Luo, Z; Qu, T; Yu, Q | 1 |
| Ito, S; Komatsubara, AT; Kyotani, Y; Nagayama, K; Ozawa, K; Tsuji, Y; Yoshizumi, M; Zhao, J | 1 |
| Cooper, PR; Fu, L; He, W; Li, D; Luo, Z; Ma, F; Wang, Z; Yu, Q; Zhang, Y; Zhou, Z | 1 |
| Kondo, A; Kozawa, O; Kuroyanagi, G; Matsushima-Nishiwaki, R; Mizutani, J; Otsuka, T; Tokuda, H; Yamamoto, N | 1 |
| Kozawa, O; Kuroyanagi, G; Matsushima-Nishiwaki, R; Mizutani, J; Nakakami, A; Otsuka, T; Tokuda, H; Yamamoto, N | 1 |
| Lu, BX; Luo, YF; Man, RY; Wang, XF; Zeng, QG; Zeng, Y | 1 |
| Ito, S; Kyotani, Y; Nagayama, K; Ozawa, K; Yoshizumi, M; Zhao, J | 1 |
| Anisuzzaman, AS; Hayashi, H; Islam, MT; Khan, MR; Suzuki, Y; Taniguchi, T; Uwada, J; Yazawa, T | 1 |
| Du, Y; Guo, YY; Li, TT; Ma, ZL; Wu, HQ; Yao, L; Zhang, GL; Zhang, L; Zhang, WG | 1 |
| Hu, Z; Li, R; Li, Y; Tian, J; Wang, C; Wang, Y; Zhou, X | 1 |
| Chen, L; Du, Y; Hong, Z; Jie, P; Li, Y; Lin, L; Tian, Y; Zhou, L | 1 |
| Choi, S; Jiao, HY; Jun, JY; Kim, MW; Kim, SW; Lee, MJ; Na, J; Park, CG; Park, IK; Shin, DH; So, I | 1 |
| Hou, M; Shi, Q; Wang, H; Weng, Y; Yan, S; Yao, J; Zuo, G | 1 |
| Choi, SK; Choi, Y; Moon, HS; Park, S | 1 |
| Cao, Q; Chen, GL; Fang, WH; Jiang, XR; Li, HH; Li, M; Li, Y; Liu, X; Ping, GF; Wang, LH; Wang, S; Wu, CF; Yang, JY | 1 |
| Dong, C; Fu, J; Liu, W; Shao, C; Tu, W; Xiao, L; Yuan, D | 1 |
| Ashley, AK; Hanneman, WH; Hinds, AI; Legare, ME; Tjalkens, RB | 1 |
| Guo, L; Hu, M; Jiao, Y; Lei, C; Wang, J; Wang, Q; Xu, J; Yang, Y | 1 |
| Dai, S; Dong, L; Li, H; Liu, Q; Peng, Y; Yuan, J | 1 |
| Gao, HW; He, YY; Khan, M; Li, YM; Ma, TH; Yang, JB; Yao, M | 1 |
| Cai, T; Chu, Q; Huang, H; Ji, H; Jiang, K; Li, J; Liu, Z; Tang, N; Wang, Y; Wu, H; Yang, C; Zhang, W | 1 |
| Choi, HJ; Choi, JY; Chung, TW; Ha, KT; Jung, YS; Kim, EY; Kim, HS; Lee, SO | 1 |
| Duan, F; Guan, R; Hong, L; Liang, H; Xu, Z; Yu, Y | 1 |
| Du, D; Li, Y; Liu, Y; Yin, Y; Zong, J | 1 |
| Li, BW; Li, Z; Tang, J; Tao, JQ; Wang, JW; Wang, LJ; Wang, WZ; Wei, S; Xie, KL; Xu, H; Xu, ZK; Yang, L; Zhang, DC; Zhang, Q; Zhi, XF; Zhu, Y | 1 |
| Chen, J; Cheng, F; Feng, J; Lan, J; Lei, Y; Mei, W; Xu, Q; Zeng, B; Zhai, Y; Zhang, W; Zhen, Y; Zheng, D | 1 |
| Chen, J; Gong, ZJ; Huang, YF; Lai, W; Lu, C; Maibach, HI; Xu, QF; Xu, XY; Zheng, Y | 1 |
| Huang, D; Lin, B; Liu, S; Liu, Y; Wang, K; Wu, W; Yu, C; Zhang, H | 1 |
| Arumugam, TV; Baik, SH; Chen, CL; Cheng, YL; Chunduri, P; Dheen, ST; Drummond, GR; Fann, DY; Jo, DG; Lim, YA; Lok, KZ; Sobey, CG | 1 |
| Dai, C; Li, B; Li, D; Tang, S; Xiao, X; Yang, X | 1 |
| Chen, JX; Ding, KF; Du, CJ; Gao, F; Hu, SM; Li, SJ; Li, Y; Mao, XW; Miyamoto, H; Wen, JM; Zhang, N; Zhang, SG | 1 |
| Hackstein, H; Ishaque, B; Liebisch, G; Lochnit, G; Rickert, M; Schmitz, G; Sluzalska, KD; Steinmeyer, J | 1 |
| Fujita, K; Kainuma, S; Kawabata, T; Kozawa, O; Kuroyanagi, G; Matsushima-Nishiwaki, R; Otsuka, T; Sakai, G; Tokuda, H; Yamamoto, N | 1 |
| Fujita, K; Kainuma, S; Kawabata, T; Kozawa, O; Matsushima-Nishiwaki, R; Otsuka, T; Sakai, G; Tokuda, H | 1 |
| Chung, YC; Hyun, CG; Kim, JH; Kim, S; Lee, GS; Lee, JN; Lee, NH | 1 |
| Berntsen, HF; Bogen, IL; Fonnum, F; Moldes-Anaya, A; Walaas, SI; Wigestrand, MB | 1 |
| Hong, L; Huang, Z; Li, H; Miao, B; Na, N; Zhang, J; Zhao, D | 1 |
| Lee, CS; Nam, YJ | 1 |
| Chen, J; Dong, J; Fu, C; Guo, Z; Li, N; Liu, Y; Wang, R; Wang, S; Yang, J; Yuan, Y; Zhang, Y | 1 |
| Lin, R; Si, L; Yang, R; Yang, S | 1 |
| Chen, Y; Geng, S; Jiang, Y; Li, X; Li, Y; Meng, Y; Wang, S; Wang, X; Wu, J; Xie, C; Yang, X; Zhong, C; Zhu, J; Zhu, W | 1 |
| Chen, T; Liu, F; Wang, D | 1 |
| Hamilton, BJ; Stan, RV; Tse, D | 1 |
| Cui, D; Xu, J; Zhao, Y | 1 |
| Jiang, X; Li, SH; Li, ZH; Liang, JX; Liao, X; Liu, HW; Wu, F; Wu, YD; Xu, Y; Yan, JX | 1 |
| Chen, H; Hou, Y; Liang, D; Liu, Y; Lou, X | 1 |
| Dong, Q; Ge, J; Huang, Q; Tian, S; Zhao, L; Zhu, H | 1 |
| Hein, TW; Kuo, L; Ren, Y; Thengchaisri, N; Tsai, SH; Xu, W; Xu, X | 1 |
| Dai, L; Jin, L; Li, S; Li, T; Qian, Y; Zhou, J; Zhu, C | 1 |
| Fan, Z; Li, P; Mei, C; Wang, X; Zhang, M; Zhao, C | 1 |
| Chung, YC; Hyun, CG; Kim, SY | 1 |
| Li, X; Liu, F; Luo, J; Yang, H; Yang, Y; Zhao, Q | 1 |
| Hanski, L; Kortesoja, M; Trofin, RE | 1 |
| Liu, J; Pan, L; Tian, Y | 1 |
| Ding, Y; He, Y; Li, J; Li, X; Lu, Y; Qi, J; Sun, Y; Wang, W; Wang, Y; Wu, H; Xu, R; Zhu, Q; Zhu, Z | 1 |
| Chen, F; Deng, Y; Qiao, S; Shi, D; Yang, S; Yang, X; Zhang, R; Zou, L | 1 |
| Fang, X; Hao, X; Li, J; Liao, R; Zhang, W; Zhong, J; Zhu, T | 1 |
| Cai, WJ; Lan, CN; Shi, J; Yi, ZJ | 1 |
| Chai, J; Jiang, S; Liu, Z; Zheng, R; Zhong, Z | 1 |
1 review(s) available for sb 203580 and pyrazolanthrone
| Article | Year |
|---|---|
Kinase Inhibitors as Underexplored Antiviral Agents.
Topics: Animals; Antiviral Agents; Drug Repositioning; Humans; Protein Kinase Inhibitors; Virus Diseases; Viruses | 2022 |
313 other study(ies) available for sb 203580 and pyrazolanthrone
| Article | Year |
|---|---|
A small molecule-kinase interaction map for clinical kinase inhibitors.
Topics: Benzamides; Drug Design; Escherichia coli; Escherichia coli Proteins; Imatinib Mesylate; Microchemistry; Pharmaceutical Preparations; Piperazines; Protein Binding; Protein Interaction Mapping; Protein Kinase Inhibitors; Pyrimidines | 2005 |
The selectivity of protein kinase inhibitors: a further update.
Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera | 2007 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2007 |
Navigating the kinome.
Topics: Drug Design; Pharmacogenetics; Protein Kinases; Proteome; Systems Biology | 2011 |
Involvement of heme oxygenase-1 induction via Nrf2/ARE activation in protection against H2O2-induced PC12 cell death by a metabolite of sesamin contained in sesame seeds.
Topics: Animals; Apoptosis; Dioxoles; Heme Oxygenase-1; Hydrogen Peroxide; Lignans; NF-E2-Related Factor 2; PC12 Cells; Rats; Seedlings; Sesamum | 2011 |
Sodium dl-α-tocopheryl-6-O-phosphate inhibits PGE₂ production in keratinocytes induced by UVB, IL-1β and peroxidants.
Topics: alpha-Tocopherol; Anti-Inflammatory Agents; Blotting, Western; Cyclooxygenase 2; Dinoprostone; Humans; In Vitro Techniques; Interleukin-1beta; Keratinocytes; Oxidants; p38 Mitogen-Activated Protein Kinases; Radiation-Protective Agents; Real-Time Polymerase Chain Reaction; RNA, Messenger; Skin; Ultraviolet Rays | 2011 |
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase | 2013 |
Inhibitory effect of resveratrol dimerized derivatives on nitric oxide production in lipopolysaccharide-induced RAW 264.7 cells.
Topics: Animals; Cell Line; Dimerization; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Resveratrol; Signal Transduction; Stilbenes; Structure-Activity Relationship | 2013 |
Discovery of diarylheptanoids that activate α7 nAchR-JAK2-STAT3 signaling in macrophages with anti-inflammatory activity in vitro and in vivo.
Topics: Animals; Anti-Inflammatory Agents; Diarylheptanoids; Janus Kinase 2; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Sepsis; STAT3 Transcription Factor | 2022 |
TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells.
Topics: Actins; Animals; Anthracenes; Cell Division; Cells, Cultured; Collagen Type I; Enzyme Inhibitors; Imidazoles; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Liver; Male; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Muscle, Smooth; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2001 |
Stress-activated protein kinase/c-Jun N-terminal kinase (JNK) plays a part in endothelin-1-induced vascular endothelial growth factor synthesis in osteoblasts.
Topics: Animals; Anthracenes; Bone and Bones; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Growth Factors; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Imidazoles; Intercellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Lymphokines; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Time Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2002 |
[Synergetic effect of mitogen-activated protein kinase pathway on expression of tumor necrosis factor alpha gene in RAW 264.7 cells induced by lipopolysaccharide].
Topics: Animals; Anthracenes; Blotting, Western; Cell Line; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genetic Vectors; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Monocytes; Mutation; p38 Mitogen-Activated Protein Kinases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha | 2002 |
Effects of transforming growth factor-[beta] and budesonide on mitogen-activated protein kinase activation and apoptosis in airway epithelial cells.
Topics: Administration, Topical; Anthracenes; Anti-Inflammatory Agents; Apoptosis; Bronchi; Budesonide; Caspase 3; Caspases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Glucocorticoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Signal Transduction; Transforming Growth Factor beta | 2003 |
Type 2 deiodinase expression is stimulated by growth factors in human vascular smooth muscle cells.
Topics: Anthracenes; Cycloheximide; Dactinomycin; Fibroblast Growth Factor 2; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Iodide Peroxidase; Iodothyronine Deiodinase Type II; Muscle, Smooth, Vascular; Proto-Oncogene Proteins c-sis; Pyridines; RNA, Messenger | 2003 |
Involvement of SAPK/JNK in basic fibroblast growth factor-induced vascular endothelial growth factor release in osteoblasts.
Topics: Animals; Anthracenes; Cell Line; Endothelial Growth Factors; Enzyme Activation; Enzyme Inhibitors; Fibroblast Growth Factor 2; Imidazoles; Intercellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Lymphokines; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Stimulation, Chemical; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
C-Jun-NH2-terminal kinase mediates expression of connective tissue growth factor induced by transforming growth factor-beta1 in human lung fibroblasts.
Topics: Androstadienes; Anthracenes; Cells, Cultured; Chromones; Connective Tissue Growth Factor; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation; Humans; Imidazoles; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Lung; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinases; Morpholines; Oligonucleotides, Antisense; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pyridines; RNA, Messenger; Smad2 Protein; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1; Wortmannin | 2003 |
The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.
Topics: Adaptor Proteins, Signal Transducing; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Anthracenes; Carrier Proteins; Dimerization; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Humans; Hybrid Cells; Imidazoles; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 5; MAP Kinase Kinase Kinases; Mice; Mitogen-Activated Protein Kinases; Neurons; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Protein Structure, Tertiary; Proteins; Pyridines; Rats; Signal Transduction | 2003 |
c-Jun N-terminal kinase negatively regulates lipopolysaccharide-induced IL-12 production in human macrophages: role of mitogen-activated protein kinase in glutathione redox regulation of IL-12 production.
Topics: Anthracenes; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Glutathione; Humans; Imidazoles; Interleukin-12; Interleukin-12 Subunit p40; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinases; Oligonucleotides, Antisense; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Protein Subunits; Pyridines; RNA, Messenger; Tumor Cells, Cultured; Up-Regulation | 2003 |
SP600125, an inhibitor of c-jun N-terminal kinase, activates CREB by a p38 MAPK-mediated pathway.
Topics: Animals; Anthracenes; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Pyridines; Serine; Transcriptional Activation | 2003 |
Sphingosine-1-phosphate-induced ERK activation protects human melanocytes from UVB-induced apoptosis.
Topics: Anthracenes; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cell Survival; Cytoprotection; Dose-Response Relationship, Radiation; Enzyme Activation; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Korea; Lysophospholipids; Melanocytes; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Pyridines; Sphingosine; Ultraviolet Rays | 2003 |
Comparison between ischaemic and anisomycin-induced preconditioning: role of p38 MAPK.
Topics: Animals; Anisomycin; Anthracenes; Cardiac Output; Coronary Circulation; Disease Models, Animal; Enzyme Activation; Heart Rate; Imidazoles; Ischemic Preconditioning, Myocardial; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Myocardial Infarction; Myocardial Ischemia; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Wistar | 2003 |
IGF-I stimulates IL-8 production in the promyelocytic cell line HL-60 through activation of extracellular signal-regulated protein kinase.
Topics: Androstadienes; Anthracenes; Apoptosis; Butadienes; Cell Survival; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Leukemic; HL-60 Cells; Humans; Hydrogen Peroxide; Imidazoles; Insulin-Like Growth Factor I; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Kinetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oxazoles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptor, IGF Type 1; RNA, Messenger; Wortmannin | 2003 |
Effect of MG132, a proteasome inhibitor, on the expression of growth related oncogene protein-alpha in human umbilical vein endothelial cells.
Topics: Acetylcysteine; Anthracenes; Cells, Cultured; Chemokine CXCL1; Chemokines, CXC; Cysteine Proteinase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; I-kappa B Proteins; Imidazoles; Intercellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Leupeptins; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Umbilical Veins | 2003 |
Verotoxin activates mitogen-activated protein kinase in human peripheral blood monocytes: role in apoptosis and proinflammatory cytokine release.
Topics: Anthracenes; Apoptosis; Blotting, Western; Cytokines; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imidazoles; Kinetics; Mitogen-Activated Protein Kinases; Monocytes; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-jun; Pyridines; Shiga Toxin; Tumor Necrosis Factor-alpha | 2003 |
p8 inhibits the growth of human pancreatic cancer cells and its expression is induced through pathways involved in growth inhibition and repressed by factors promoting cell growth.
Topics: Anthracenes; Basic Helix-Loop-Helix Transcription Factors; Butadienes; Cell Line, Tumor; Cell Proliferation; Culture Media; Culture Media, Serum-Free; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Silencing; Genetic Vectors; Growth Inhibitors; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Nitriles; Pancreatic Neoplasms; Proto-Oncogene Proteins c-raf; Pyridines; ras Proteins; Retroviridae; RNA, Antisense; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2003 |
p38 MAP kinase mediates bilirubin-induced neuronal death of cultured rat cerebellar granule neurons.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anthracenes; Bilirubin; Blotting, Western; Cell Death; Cell Survival; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Imidazoles; Mitogen-Activated Protein Kinases; Neurons; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Time Factors | 2003 |
Reciprocal regulation of beta-adrenergic receptor mRNA stability by mitogen activated protein kinase activation and inhibition.
Topics: 3' Untranslated Regions; Animals; Anisomycin; Anthracenes; Butadienes; Cell Line; Cricetinae; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Heterogeneous-Nuclear Ribonucleoproteins; Imidazoles; Mitogen-Activated Protein Kinase Kinases; Nitriles; Nucleic Acid Synthesis Inhibitors; Phosphatidylinositol 3-Kinases; Pyridines; Receptors, Adrenergic, beta; RNA Stability; Signal Transduction | 2004 |
The hierarchical relationship between MAPK signaling and ROS generation in human leukemia cells undergoing apoptosis in response to the proteasome inhibitor Bortezomib.
Topics: Anthracenes; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Caspases; Cytochromes c; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Leukemia; MAP Kinase Signaling System; Membrane Potentials; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Models, Biological; Protease Inhibitors; Pyrazines; Pyridines; Reactive Oxygen Species; Signal Transduction; U937 Cells | 2004 |
Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor.
Topics: Angiotensin II; Animals; Anthracenes; Blotting, Western; Cells, Cultured; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Flavonoids; Genistein; Imidazoles; Kidney; Losartan; Mice; Microscopy, Fluorescence; Onium Compounds; PAX2 Transcription Factor; Phosphorylation; Plasmids; Pyridines; Receptors, Angiotensin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Transcription Factors; Tyrphostins; Up-Regulation | 2004 |
Involvement of SAPK/JNK in prostaglandin E(1)-induced VEGF synthesis in osteoblast-like cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Alprostadil; Animals; Anthracenes; Cell Line; Colforsin; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mice; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-jun; Pyridines; Vascular Endothelial Growth Factor A | 2004 |
Induction of matrix metalloproteinase-2 by tenascin-X deficiency is mediated through the c-Jun N-terminal kinase and protein tyrosine kinase phosphorylation pathway.
Topics: Androstadienes; Animals; Animals, Newborn; Anthracenes; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Genistein; Imidazoles; Male; Matrix Metalloproteinase 2; Mice; Mice, Knockout; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-jun; Pyridines; Skin; Tenascin; Wortmannin | 2004 |
Glucose-potentiated chemotaxis in human vascular smooth muscle is dependent on cross-talk between the PI3K and MAPK signaling pathways.
Topics: Alkyl and Aryl Transferases; Androstadienes; Anthracenes; Antibodies, Monoclonal; Cells, Cultured; Chemotaxis; Chromones; Class I Phosphatidylinositol 3-Kinases; Farnesyltranstransferase; Flavonoids; Glucose; Humans; Imidazoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Lovastatin; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Polyisoprenyl Phosphates; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; ras Proteins; Sesquiterpenes; Sirolimus; TOR Serine-Threonine Kinases; Wortmannin | 2004 |
Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets.
Topics: Androstadienes; Anthracenes; Apoptosis; Cell Death; Culture Techniques; Cytokines; Cytoprotection; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Insulin-Like Growth Factor I; Islets of Langerhans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Tissue Survival; Wortmannin | 2004 |
Mood stabilizers inhibit glucocorticoid receptor function in LMCAT cells.
Topics: Amphetamine; Animals; Anthracenes; Antimanic Agents; Blotting, Western; Carbamazepine; Cell Line; Cell Survival; Chloramphenicol O-Acetyltransferase; Corticosterone; Dose-Response Relationship, Drug; Flavonoids; Gene Expression Regulation, Enzymologic; Imidazoles; Indoles; Inositol; Lithium; Maleimides; Protein Kinase C; Protein Kinase C-alpha; Pyridines; Receptors, Glucocorticoid; Tamoxifen; Tetradecanoylphorbol Acetate; Valproic Acid | 2004 |
p21(Cip-1/SDI-1/WAF-1) expression via the mitogen-activated protein kinase signaling pathway in insulin-induced chondrogenic differentiation of ATDC5 cells.
Topics: Animals; Anthracenes; Butadienes; Cell Differentiation; Cell Line; Chondrocytes; Chondrogenesis; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Imidazoles; Insulin; Mice; Mitogen-Activated Protein Kinases; Nitriles; Pyridines; Signal Transduction | 2004 |
Curcumin induces c-jun N-terminal kinase-dependent apoptosis in HCT116 human colon cancer cells.
Topics: Anthracenes; Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Curcumin; Enzyme Inhibitors; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; NF-kappa B; Pyridines; Signal Transduction | 2004 |
MAP kinases differentially regulate the expression of macrophage hyperactivity after thermal injury.
Topics: Animals; Anthracenes; Burns; Enzyme Inhibitors; Female; Flavonoids; Imidazoles; Immunophenotyping; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Tumor Necrosis Factor-alpha | 2004 |
Interleukin-4 increases murine airway response to kinins, via up-regulation of bradykinin B1-receptors and altered signalling along mitogen-activated protein kinase pathways.
Topics: Animals; Anthracenes; Bradykinin; Dactinomycin; Dexamethasone; Electromyography; Enzyme Inhibitors; Flavonoids; Imidazoles; In Vitro Techniques; Interleukin-4; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Pyridines; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Trachea | 2004 |
Mechanical stimulation and mitogen-activated protein kinase signaling independently regulate osteogenic differentiation and mineralization by calcifying vascular cells.
Topics: Alkaline Phosphatase; Animals; Anthracenes; Butadienes; Calcification, Physiologic; Cattle; Cell Differentiation; Cell Line; Cell Proliferation; DNA; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Imidazoles; JNK Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Nitriles; Osteogenesis; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Stress, Mechanical | 2004 |
Andrographolide acts through inhibition of ERK1/2 and Akt phosphorylation to suppress chemotactic migration.
Topics: Androstadienes; Animals; Anthracenes; Cell Line; Cell Movement; Cell Survival; Chemokine CCL4; Chemotaxis; Chromones; Complement C5a; Diterpenes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Macrophage Inflammatory Proteins; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Wortmannin | 2004 |
Role of c-Jun N-terminal kinase on lipopolysaccharide induced maturation of human monocyte-derived dendritic cells.
Topics: Anthracenes; Antigens, CD; Biological Transport; Cell Differentiation; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Dendritic Cells; Dextrans; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Fluorescein-5-isothiocyanate; HLA-DR Antigens; Humans; Imidazoles; Interleukin-12; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Monocytes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Protein Subunits; Pyridines; Tumor Necrosis Factor-alpha; Up-Regulation | 2004 |
Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Anthracenes; Aorta, Thoracic; Bacterial Proteins; Benzopyrans; Butadienes; Catheterization; Cell Division; Dipeptides; ErbB Receptors; Flavonoids; Glycine; Hydroxamic Acids; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; Organ Culture Techniques; Phenylephrine; Phosphorylation; Protein Processing, Post-Translational; Pyridines; Quinazolines; Rats; Receptors, Adrenergic, alpha-1; Thrombin; Tyrphostins | 2004 |
High sensitivity of fibroblast cell lines derived from LEC rats to heat treatment.
Topics: Animals; Anthracenes; Apoptosis; Cell Line; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Fibroblasts; Flow Cytometry; Hot Temperature; HSP70 Heat-Shock Proteins; Imidazoles; Immunoblotting; Pyridines; Rats; Rats, Inbred LEC; Sphingosine; Time Factors | 2004 |
Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation.
Topics: Animals; Anthracenes; Brain-Derived Neurotrophic Factor; Butadienes; Enzyme Activation; Ganglia, Spinal; Gene Expression Regulation; Hot Temperature; Hyperalgesia; Imidazoles; Ion Channels; JNK Mitogen-Activated Protein Kinases; Ligation; Lumbar Vertebrae; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons, Afferent; Nitriles; p38 Mitogen-Activated Protein Kinases; Physical Stimulation; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Rhizotomy; Spinal Nerves; Stress, Mechanical; TRPV Cation Channels | 2004 |
Superoxide dismutase inhibits the expression of vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1 induced by tumor necrosis factor-alpha in human endothelial cells through the JNK/p38 pathways.
Topics: Anthracenes; Aorta; Arteriosclerosis; Cell Adhesion; Depression, Chemical; Endothelial Cells; Endothelium, Vascular; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Inflammation; Intercellular Adhesion Molecule-1; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; NADPH Oxidases; Neutrophils; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Pyridines; Recombinant Fusion Proteins; Superoxide Dismutase; Superoxide Dismutase-1; Superoxides; Transcription Factor AP-1; Transcription, Genetic; Transduction, Genetic; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2005 |
Secreted beta-amyloid precursor protein activates microglia via JNK and p38-MAPK.
Topics: Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Anthracenes; Blotting, Western; Butadienes; Cells, Cultured; Dose-Response Relationship, Drug; Drug Combinations; Extracellular Signal-Regulated MAP Kinases; Imidazoles; JNK Mitogen-Activated Protein Kinases; Microglia; Nitriles; Nitrites; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Time Factors | 2005 |
Induction of apoptosis and cytokine production in the Jurkat human T cells by deoxynivalenol: role of mitogen-activated protein kinases and comparison to other 8-ketotrichothecenes.
Topics: Anthracenes; Apoptosis; Caspase 3; Caspases; Cytokines; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Humans; Imidazoles; Immunotoxins; Jurkat Cells; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Mycotoxins; Phosphorylation; Pyridines; T-Lymphocytes; Trichothecenes | 2005 |
Implication of the MAPK pathways in the maturation of human dendritic cells induced by nickel and TNF-alpha.
Topics: Anthracenes; Antigens, CD; Antigens, Surface; B7-2 Antigen; Blotting, Western; Cadherins; CD83 Antigen; Enzyme Inhibitors; Female; Flavonoids; Flow Cytometry; Humans; Imidazoles; Immunoglobulins; Irritants; Langerhans Cells; Lectins, C-Type; Mannose-Binding Lectins; MAP Kinase Signaling System; Membrane Glycoproteins; Mitogen-Activated Protein Kinases; Nickel; Pyridines; Receptors, CCR7; Receptors, Chemokine; Tumor Necrosis Factor-alpha | 2005 |
Interleukin-1beta-induced transdifferentiation of renal proximal tubular cells is mediated by activation of JNK and p38 MAPK.
Topics: Actins; Anthracenes; Cell Differentiation; Cell Line; Cell Movement; Down-Regulation; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Fibronectins; Flavonoids; Humans; Imidazoles; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Keratins; Kidney Tubules, Proximal; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction | 2005 |
KR-31378 protects cardiac H9c2 cells from chemical hypoxia-induced cell death via inhibition of JNK/p38 MAPK activation.
Topics: Animals; Anthracenes; Butadienes; Cell Death; Cell Hypoxia; Cell Line; Enzyme Activation; Guanidines; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Molecular Structure; Myocardium; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyrans; Pyridines; Reactive Oxygen Species | 2004 |
Requirement for ERK activation in acetone extract identified from Bupleurum scorzonerifolium induced A549 tumor cell apoptosis and keratin 8 phosphorylation.
Topics: Anthracenes; Apoptosis; Bupleurum; Chromatography, Liquid; Drugs, Chinese Herbal; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Humans; Imidazoles; Immunoblotting; Keratin-8; Keratins; Mass Spectrometry; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Pyridines; Tumor Cells, Cultured | 2005 |
Interleukin-25-induced chemokines and interleukin-6 release from eosinophils is mediated by p38 mitogen-activated protein kinase, c-Jun N-terminal kinase, and nuclear factor-kappaB.
Topics: Anthracenes; Base Sequence; Chemokines; DNA, Complementary; Eosinophils; Humans; Imidazoles; In Vitro Techniques; Intercellular Adhesion Molecule-1; Interleukin-17; Interleukin-6; Interleukins; JNK Mitogen-Activated Protein Kinases; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Interleukin; Recombinant Proteins; Sulfones | 2005 |
Eosinophil migration induced by mast cell chymase is mediated by extracellular signal-regulated kinase pathway.
Topics: Animals; Anthracenes; Blotting, Western; Butadienes; Butyric Acid; Cell Line, Tumor; Cell Movement; Chemotaxis; Chymases; Enzyme Inhibitors; Eosinophils; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mast Cells; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 3; Nitriles; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Pyridines; Receptors, G-Protein-Coupled; Serine Endopeptidases; Signal Transduction; Time Factors | 2005 |
Hibiscus anthocyanins rich extract-induced apoptotic cell death in human promyelocytic leukemia cells.
Topics: Androstadienes; Anthocyanins; Anthracenes; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Caspases; Cell Survival; Cytochromes c; DNA, Mitochondrial; Dose-Response Relationship, Drug; Fas Ligand Protein; Flavonoids; Flowers; Hibiscus; HL-60 Cells; Humans; Imidazoles; Membrane Glycoproteins; p38 Mitogen-Activated Protein Kinases; Plant Extracts; Proto-Oncogene Proteins c-jun; Pyridines; RNA, Messenger; Time Factors; Wortmannin | 2005 |
Polypeptide from Chlamys farreri inhibits murine thymocytes apoptosis and modulates UVB induced signaling pathway activation.
Topics: Analysis of Variance; Animals; Anthracenes; Apoptosis; Blotting, Western; Cells, Cultured; DNA Fragmentation; Flavonoids; Imidazoles; Mice; Microscopy, Electron, Transmission; Mitogen-Activated Protein Kinases; Mollusca; Peptides; Pyridines; Signal Transduction; Thymus Gland; Ultraviolet Rays | 2005 |
Radical mediators and mitogen-activated protein kinase signaling in oxygen-dependent radiosensitivity of human tumor cell lines.
Topics: Acetylcysteine; Anthracenes; Antioxidants; Apoptosis; Ascorbic Acid; Butadienes; Cell Line, Tumor; Cell Proliferation; DNA Damage; Enzyme Inhibitors; Fluoresceins; HeLa Cells; Humans; Imidazoles; MAP Kinase Signaling System; Melatonin; Mitochondria; Nitriles; Nitrites; Oxazines; Oxygen; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Radiation Tolerance; Rhodamines; Spectrometry, Fluorescence; Xanthenes | 2005 |
Inflammatory pathway analysis using a high content screening platform.
Topics: Anthracenes; Cell Line, Tumor; Cell Nucleus; Cytosol; Enzyme Inhibitors; Fluorescence; Fluorescent Antibody Technique; HeLa Cells; Humans; Imidazoles; Immunoblotting; Inflammation; Interleukin-1; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reproducibility of Results; RNA, Small Interfering; Signal Transduction; Technology, Pharmaceutical; Transcription Factor RelA; Transfection | 2005 |
Multiple anti-apoptotic pathways stimulated by EGF in cytotrophoblasts.
Topics: Adaptor Proteins, Signal Transducing; Adult; Anthracenes; Apoptosis; Cell Culture Techniques; Chorionic Villi; Drug Combinations; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Female; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pregnancy; Pyridines; Signal Transduction; Trophoblasts | 2005 |
Human immunodeficiency virus type 1 envelope glycoprotein 120 induces cyclooxygenase-2 expression in neuroblastoma cells through a nuclear factor-kappaB and activating protein-1 mediated mechanism.
Topics: Anthracenes; Antioxidants; Blotting, Northern; CD4 Antigens; Cell Line, Tumor; Chemokine CCL5; Chemokine CXCL12; Chemokines, CXC; Cyclooxygenase 2; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Gene Expression; HIV Envelope Protein gp120; Humans; Imidazoles; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Luciferases; Membrane Proteins; Mutagenesis; Neuroblastoma; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Proline; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins c-jun; Pyridines; Receptors, CCR5; Receptors, CXCR4; Thiocarbamates; Time Factors; Transcription Factor AP-1; Transfection; Tumor Necrosis Factor-alpha | 2005 |
Inflammatory responses of corneal epithelial cells to Pseudomonas aeruginosa infection.
Topics: Anthracenes; Blotting, Western; Cell Culture Techniques; Cytokines; Diterpenes; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epithelium, Corneal; Humans; I-kappa B Proteins; Imidazoles; Interleukin-6; Interleukin-8; JNK Mitogen-Activated Protein Kinases; NF-kappa B; NF-KappaB Inhibitor alpha; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pseudomonas aeruginosa; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA; Tumor Necrosis Factor-alpha | 2005 |
Regulation of cAMP-induced arylalkylamine N-acetyltransferase, Period1, and MKP-1 gene expression by mitogen-activated protein kinases in the rat pineal gland.
Topics: Analysis of Variance; Animals; Anthracenes; Arylamine N-Acetyltransferase; Blotting, Western; Cell Cycle Proteins; Cyclic AMP; Drug Interactions; Dual Specificity Phosphatase 1; Enzyme Inhibitors; Eye Proteins; Gene Expression Regulation; Imidazoles; Immediate-Early Proteins; Immunohistochemistry; Male; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinases; Molecular Weight; Organ Culture Techniques; Period Circadian Proteins; Phosphoprotein Phosphatases; Pineal Gland; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Pyridines; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Time Factors | 2005 |
Involvement of histone acetyltransferase (HAT) in ethanol-induced acetylation of histone H3 in hepatocytes: potential mechanism for gene expression.
Topics: Acetylation; Alcohol Dehydrogenase; Animals; Anthracenes; Butadienes; Ethanol; Gene Expression Regulation, Enzymologic; Hepatocytes; Histone Acetyltransferases; Histones; Imidazoles; Male; MAP Kinase Signaling System; Nitriles; Pyridines; Rats; Rats, Sprague-Dawley | 2005 |
Mitogen-activated protein kinases (MAPKs) mediate SIN-1/ glucose deprivation-induced death in rat primary astrocytes.
Topics: Adenosine Triphosphate; Animals; Anthracenes; Astrocytes; Brain Ischemia; Cell Culture Techniques; Cell Death; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glucose; Imidazoles; L-Lactate Dehydrogenase; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Molsidomine; Nitric Oxide Donors; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Pyridines; Rats; Rats, Sprague-Dawley | 2005 |
Matrix metalloproteinase-2 and -9 are induced differently by doxorubicin in H9c2 cells: The role of MAP kinases and NAD(P)H oxidase.
Topics: Anthracenes; Antibiotics, Antineoplastic; Antioxidants; Blotting, Western; Carbazoles; Carvedilol; Catecholamines; Cell Line; Doxorubicin; Enzyme Activation; Flavonoids; Humans; Imidazoles; Imidazolines; Janus Kinase 1; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinases; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Propanolamines; Protein-Tyrosine Kinases; Pyridines; Razoxane | 2006 |
Inhibitors of mitogen-activated protein kinases downregulate COX-2 expression in human chondrocytes.
Topics: Anthracenes; Chondrocytes; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Interleukin-1; Mitogen-Activated Protein Kinases; Pyridines; RNA, Messenger; Signal Transduction | 2005 |
Shiga toxin 1-induced cytokine production is mediated by MAP kinase pathways and translation initiation factor eIF4E in the macrophage-like THP-1 cell line.
Topics: Aniline Compounds; Anisomycin; Anthracenes; Cell Line, Tumor; Cytokines; Dose-Response Relationship, Drug; Eukaryotic Initiation Factor-4E; Flavonoids; Humans; Imidazoles; Lipopolysaccharides; Macrophages; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Phosphorylation; Purines; Pyridines; RNA, Messenger; Shiga Toxin 1; Time Factors | 2006 |
Involvement of COX-2 in VEGF-induced angiogenesis via P38 and JNK pathways in vascular endothelial cells.
Topics: Anthracenes; Butadienes; Cells, Cultured; Cyclooxygenase 2; Endothelial Cells; Endothelium, Vascular; Gene Deletion; Humans; Imidazoles; MAP Kinase Kinase 4; Membrane Proteins; Neovascularization, Physiologic; Nitriles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; RNA, Small Interfering; Signal Transduction; Sulfonamides; Vascular Endothelial Growth Factor A | 2006 |
Opposing effect of p38 MAP kinase and JNK inhibitors on the development of heart failure in the cardiomyopathic hamster.
Topics: Animals; Anthracenes; Apoptosis; Cardiomyopathy, Dilated; Cricetinae; Fibrosis; Imidazoles; Immunoblotting; In Situ Nick-End Labeling; JNK Mitogen-Activated Protein Kinases; Male; Microscopy, Fluorescence; Myocardium; p38 Mitogen-Activated Protein Kinases; Pyrazoles; Pyridines; Ventricular Dysfunction, Left | 2006 |
The roles of Akt and MAPK family members in silymarin's protection against UV-induced A375-S2 cell apoptosis.
Topics: Algorithms; Anthracenes; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Down-Regulation; Flavonoids; Genes, bcl-2; Genes, p53; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Silymarin; Ultraviolet Rays | 2006 |
Porphyromonas gingivalis-related cardiac cell apoptosis was majorly co-activated by p38 and extracellular signal-regulated kinase pathways.
Topics: Animals; Anthracenes; Apoptosis; Butadienes; Calcineurin Inhibitors; Caspases; Cell Nucleus; Chromones; Cyclosporine; DNA Fragmentation; Enzyme Inhibitors; Fluorescent Dyes; Imidazoles; Indoles; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Morpholines; Myocardium; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Porphyromonas gingivalis; Pyridines; Rats | 2006 |
The effects of ZD1839 (Iressa), a highly selective EGFR tyrosine kinase inhibitor, as a radiosensitiser in bile duct carcinoma cell lines.
Topics: Anthracenes; Bile Duct Neoplasms; Butadienes; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromones; Clone Cells; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Gefitinib; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oncogene Protein v-akt; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Quinazolines; Radiation-Sensitizing Agents | 2006 |
Interleukin-1 beta up-regulates tissue inhibitor of matrix metalloproteinase-1 mRNA and phosphorylation of c-jun N-terminal kinase and p38 in hepatic stellate cells.
Topics: Animals; Anthracenes; Blotting, Western; Cell Line; Enzyme Inhibitors; Imidazoles; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Liver; Liver Cirrhosis; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Tissue Inhibitor of Metalloproteinase-1; Up-Regulation | 2006 |
Differential transcriptional responses of keloid and normal keratinocytes to serum stimulation.
Topics: Adolescent; Adult; Anthracenes; Blood Proteins; Culture Media, Conditioned; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Keloid; Keratinocytes; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Pyridines; Transcription, Genetic; Transforming Growth Factor beta; Transforming Growth Factor beta2; Transforming Growth Factor beta3 | 2006 |
MAP kinase regulation of IP10/CXCL10 chemokine gene expression in microglial cells.
Topics: Analysis of Variance; Animals; Anthracenes; Blotting, Western; Cell Line; Chemokine CXCL10; Chemokines, CXC; Drug Interactions; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Gene Expression; Gene Expression Regulation; Imidazoles; Interferon-gamma; Lipopolysaccharides; Luciferases; Mice; Microglia; Mitogen-Activated Protein Kinases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection | 2006 |
Involvement of p38 MAP kinase and Smad3 in TGF-beta-mediated mast cell functions.
Topics: Animals; Anthracenes; Blotting, Western; Bone Marrow Cells; Cell Movement; Cell Proliferation; Cells, Cultured; Chymases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Imidazoles; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Smad3 Protein; Transforming Growth Factor beta; Tryptases; Up-Regulation | 2006 |
Immune regulation of 25-hydroxyvitamin D-1alpha-hydroxylase in human monocytic THP1 cells: mechanisms of interferon-gamma-mediated induction.
Topics: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Anthracenes; Blotting, Western; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Cell Line; Enzyme Induction; Flavonoids; Humans; Imidazoles; Interferon-gamma; Mitogen-Activated Protein Kinases; Monocytes; Protein Kinase Inhibitors; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction; STAT1 Transcription Factor; Tetradecanoylphorbol Acetate | 2006 |
Ligustilide inhibits vascular smooth muscle cells proliferation.
Topics: 4-Butyrolactone; Animals; Anthracenes; Blotting, Western; Cell Cycle; Cell Proliferation; Cells, Cultured; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Enzyme Activation; Flavonoids; Imidazoles; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphorylation; Pyridines; Rats; Rats, Wistar; Reactive Oxygen Species; Retinoblastoma Protein | 2006 |
PPARgamma phosphorylation mediated by JNK MAPK: a potential role in macrophage-derived foam cell formation.
Topics: Anthracenes; Cell Differentiation; Cell Line, Tumor; Dose-Response Relationship, Drug; Foam Cells; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Leukemia, Monocytic, Acute; Lipoproteins, LDL; Macrophages; Mitogen-Activated Protein Kinases; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phosphorylation; PPAR gamma; Pyridines | 2006 |
Activation of mitogen-activated protein kinases is essential for hydrogen peroxide -induced apoptosis in retinal pigment epithelial cells.
Topics: Active Transport, Cell Nucleus; Anthracenes; Apoptosis; Apoptosis Regulatory Proteins; Bacterial Proteins; Bacterial Toxins; Cell Line, Tumor; Cell Nucleus; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 8; p38 Mitogen-Activated Protein Kinases; Pigment Epithelium of Eye; Protein Transport; Pyridines; rac1 GTP-Binding Protein | 2006 |
Emodin inhibits TNF alpha-induced MMP-1 expression through suppression of activator protein-1 (AP-1).
Topics: Anthracenes; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Emodin; Fibroblasts; Flavonoids; Humans; Imidazoles; Infant, Newborn; JNK Mitogen-Activated Protein Kinases; Luciferases; Male; Matrix Metalloproteinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Pyridines; Rheum; Transcription Factor AP-1; Transfection; Tumor Necrosis Factor-alpha | 2006 |
Involvement of MAP kinases in lipopolysaccharide-induced histamine production in RAW 264 cells.
Topics: Animals; Anthracenes; Butadienes; Cell Line; Extracellular Signal-Regulated MAP Kinases; Histamine; Histidine Decarboxylase; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; RNA, Messenger | 2006 |
P38 MAPK protects against TNF-alpha-provoked apoptosis in LNCaP prostatic cancer cells.
Topics: Anthracenes; Apoptosis; Blotting, Western; Cell Line, Tumor; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Male; p38 Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Tumor Necrosis Factor-alpha | 2006 |
The c-Jun-N-terminal-Kinase inhibitor SP600125 enhances the butyrate derivative D1-induced apoptosis via caspase 8 activation in Kasumi 1 t(8;21) acute myeloid leukaemia cells.
Topics: Anthracenes; Apoptosis; Blotting, Western; Butyrates; Caspase 8; Cell Line, Tumor; Chromosomes, Human, Pair 21; Chromosomes, Human, Pair 8; Drug Administration Schedule; Drug Therapy, Combination; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Histone Deacetylase Inhibitors; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Leukemia, Myeloid, Acute; Mannose; p38 Mitogen-Activated Protein Kinases; Pyridines; Translocation, Genetic | 2006 |
Ca2+ stimulates COX-2 expression through calcium-sensing receptor in fibroblasts.
Topics: Anthracenes; Bone and Bones; Calcium; Calcium Signaling; Cations, Divalent; Cyclooxygenase 2; Dinoprostone; Estrenes; Fibroblasts; Flavonoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Pyrrolidinones; Receptors, Calcium-Sensing; RNA, Messenger; Type C Phospholipases | 2006 |
Induced secretion of insulin-like growth factor binding protein-1 (IGFBP-1) in human hepatoma cell HepG2 by rubratoxin B.
Topics: Anthracenes; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Humans; Imidazoles; Insulin-Like Growth Factor Binding Protein 1; JNK Mitogen-Activated Protein Kinases; Mycotoxins; p38 Mitogen-Activated Protein Kinases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2007 |
Interleukin-1beta up-regulates inducible nitric oxide by way of phosphoinositide 3-kinase-dependent in a cochlear cell model.
Topics: Animals; Anthracenes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromones; Enzyme Inhibitors; Flavonoids; Imidazoles; Interleukin-1beta; Mice; Morpholines; Nitric Oxide Synthase Type II; Organ of Corti; Phosphatidylinositol 3-Kinases; Pyridines; Signal Transduction; Transcriptional Activation; Up-Regulation | 2006 |
A novel pathway for transcriptional regulation of alpha-synuclein.
Topics: alpha-Synuclein; Animals; Anthracenes; Blotting, Western; Butadienes; Chromones; Enzyme Inhibitors; Fibroblast Growth Factor 2; Gene Expression Regulation; Humans; Imidazoles; Introns; JNK Mitogen-Activated Protein Kinases; Models, Biological; Morpholines; Nerve Growth Factor; Nitriles; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic | 2007 |
In vitro evidence for role of ERK, p38, and JNK in exocrine pancreatic cytokine production.
Topics: Animals; Anthracenes; Calcium-Calmodulin-Dependent Protein Kinases; Ceruletide; Cytokines; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pancreas, Exocrine; Pyridines; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2006 |
Inhibitory effect of TNF-alpha on the intestinal absorption of galactose.
Topics: Animals; Anthracenes; Blotting, Northern; Blotting, Western; Cell Membrane; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Galactose; Imidazoles; Indoles; Injections, Intravenous; Intestinal Absorption; Intestinal Mucosa; Intestines; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Male; Maleimides; Microvilli; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Peptides; Proteasome Inhibitors; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; Rabbits; RNA, Messenger; Sepsis; Sodium-Glucose Transporter 1; Tumor Necrosis Factor-alpha | 2007 |
p38MAPK activation is involved in androgen-independent proliferation of human prostate cancer cells by regulating IL-6 secretion.
Topics: Androgens; Anthracenes; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; Interleukin-6; Male; p38 Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Pyridines; Ritodrine | 2007 |
EGCG-targeted p57/KIP2 reduces tumorigenicity of oral carcinoma cells: role of c-Jun N-terminal kinase.
Topics: Animals; Anthracenes; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Catechin; Cell Line; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p57; Cytochromes c; Disease-Free Survival; Enzyme Inhibitors; Female; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Nude; Mouth Neoplasms; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Signal Transduction; Transfection; Xenograft Model Antitumor Assays | 2007 |
Pravastatin induces thrombomodulin expression in TNFalpha-treated human aortic endothelial cells by inhibiting Rac1 and Cdc42 translocation and activity.
Topics: Amides; Anthracenes; Aorta; Blotting, Western; Boron Compounds; cdc42 GTP-Binding Protein; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Endothelial Cells; Enzyme Activation; Flavonoids; Humans; Imidazoles; Leucine; Mitogen-Activated Protein Kinases; Phosphorylation; Pravastatin; Protein Transport; Pyridines; rac1 GTP-Binding Protein; Thrombomodulin; Time Factors; Tumor Necrosis Factor-alpha | 2007 |
Predominant activation of MAP kinases and pro-destructive/pro-inflammatory features by TNF alpha in early-passage synovial fibroblasts via TNF receptor-1: failure of p38 inhibition to suppress matrix metalloproteinase-1 in rheumatoid arthritis.
Topics: Anthracenes; Arthritis, Rheumatoid; Blotting, Western; Butadienes; Case-Control Studies; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Humans; Imidazoles; MAP Kinase Kinase 4; Matrix Metalloproteinase 1; Matrix Metalloproteinase Inhibitors; Nitriles; Osteoarthritis; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Signal Transduction; Statistics, Nonparametric; Synovial Membrane; Tumor Necrosis Factor-alpha | 2007 |
Suppression of endoplasmic reticulum stress-induced caspase activation and cell death by the overexpression of Bcl-xL or Bcl-2.
Topics: Animals; Anthracenes; Apoptosis; bcl-X Protein; Brefeldin A; Caspase 2; Caspase 9; Cytochromes c; Endoplasmic Reticulum; Enzyme Activation; Imidazoles; JNK Mitogen-Activated Protein Kinases; NFI Transcription Factors; PC12 Cells; Proto-Oncogene Proteins c-bcl-2; Pyridines; Rats; Transfection | 2007 |
Apoptotic effect of 3,4-dihydroxybenzoic acid on human gastric carcinoma cells involving JNK/p38 MAPK signaling activation.
Topics: Adenocarcinoma; Anthracenes; Apoptosis; Cell Cycle; Enzyme Inhibitors; Humans; Hydroxybenzoates; Imidazoles; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitochondria; p38 Mitogen-Activated Protein Kinases; Pyridines; Stomach Neoplasms | 2007 |
[The role of MAPK/ERK1/2 signaling pathway in aldosterone stimulated transforming growth factor-beta1 synthesis in renal tubular epithelial cells].
Topics: Aldosterone; Anthracenes; Blotting, Western; Butadienes; Cells, Cultured; Dose-Response Relationship, Drug; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; Kidney Tubules, Proximal; Mifepristone; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Phosphorylation; Pyridines; Signal Transduction; Time Factors; Transforming Growth Factor beta1 | 2006 |
(-)-Epigallocatechin gallate suppresses endothelin-1-induced interleukin-6 synthesis in osteoblasts: inhibition of p44/p42 MAP kinase activation.
Topics: Animals; Anthracenes; Catechin; Cells, Cultured; Endothelin-1; Enzyme Activation; Flavonoids; Imidazoles; Interleukin-6; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Proto-Oncogene Proteins c-raf; Pyridines; Tetradecanoylphorbol Acetate | 2007 |
Differential regulation of indoleamine 2,3-dioxygenase by lipopolysaccharide and interferon gamma in murine bone marrow derived dendritic cells.
Topics: Animals; Anthracenes; Bone Marrow Cells; Butadienes; Chromones; Dendritic Cells; Gene Expression; Gene Expression Regulation, Enzymologic; Imidazoles; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Janus Kinase 1; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Male; Mice; Mice, Inbred Strains; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyridines | 2007 |
IKappaB-kinase/nuclear factor-kappaB signaling prevents thermal injury-induced gut damage by inhibiting c-Jun NH2-terminal kinase activation.
Topics: Animals; Anthracenes; Apoptosis; bcl-X Protein; Burns; Caspase 3; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; I-kappa B Kinase; Imidazoles; Intestinal Mucosa; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Knockout; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Permeability; Phosphorylation; Pyridines; RNA, Messenger; Signal Transduction | 2007 |
Flashlamp pulsed-dye laser suppressed TGF-beta1 expression and proliferation in cultured keloid fibroblasts is mediated by MAPK pathway.
Topics: Anthracenes; Cell Proliferation; Cells, Cultured; Down-Regulation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Keloid; Low-Level Light Therapy; Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Transcription Factor AP-1; Transforming Growth Factor beta1 | 2007 |
Involvement of glycogen synthase kinase-3beta in palmitate-induced human umbilical vein endothelial cell apoptosis.
Topics: Adenoviridae; Anthracenes; Apoptosis; Caspase 3; Cell Cycle; Cells, Cultured; Cytosol; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Fumonisins; Genetic Vectors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Imidazoles; Indoles; Lithium Chloride; Maleimides; Mitochondria; Palmitates; Phosphorylation; Phosphoserine; Poly(ADP-ribose) Polymerases; Protein Processing, Post-Translational; Pyridines; Thiadiazoles; Transduction, Genetic; Umbilical Veins | 2007 |
Human lung innate immune response to Bacillus anthracis spore infection.
Topics: Anthracenes; Anthrax; Bacillus anthracis; Butadienes; Chemokines; Cytokines; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Gene Expression Regulation; Humans; Imidazoles; Immunity, Innate; Immunohistochemistry; In Vitro Techniques; Lung; Macrophages, Alveolar; MAP Kinase Signaling System; Microscopy, Fluorescence; Nitriles; Pulmonary Alveoli; Pyridines; RNA, Messenger; Spores, Bacterial | 2007 |
Promotion of cancer cell migration: an insulin-like growth factor (IGF)-independent action of IGF-binding protein-6.
Topics: Anthracenes; Cell Movement; Humans; Imidazoles; Insulin-Like Growth Factor Binding Protein 6; Insulin-Like Growth Factor I; Ligands; MAP Kinase Signaling System; Mutation; Neoplasms; p38 Mitogen-Activated Protein Kinases; Protein Binding; Protein Structure, Tertiary; Pyridines; Rhabdomyosarcoma; Tumor Cells, Cultured | 2007 |
Inhibition of ERK and JNK decreases both osmosensitive taurine release and cell proliferation in glioma cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Anthracenes; Apoptosis; Astrocytoma; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dicumarol; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; Ion Channels; JNK Mitogen-Activated Protein Kinases; Necrosis; Niflumic Acid; Nitrobenzoates; Osmolar Concentration; Pyridines; Rats; Taurine | 2007 |
Beta-sitosterol-induced-apoptosis is mediated by the activation of ERK and the downregulation of Akt in MCA-102 murine fibrosarcoma cells.
Topics: Animals; Anthracenes; Apoptosis; Apoptosis Regulatory Proteins; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cell Survival; Chromones; Dose-Response Relationship, Drug; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Fibrosarcoma; G1 Phase; Hypolipidemic Agents; Imidazoles; Mice; Models, Biological; Morpholines; Oligopeptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyridines; Signal Transduction; Sitosterols; Tumor Suppressor Protein p53 | 2007 |
Histone H3 phosphorylation at serine 10 and serine 28 is mediated by p38 MAPK in rat hepatocytes exposed to ethanol and acetaldehyde.
Topics: Acetaldehyde; Animals; Anthracenes; Blotting, Western; Caspase 3; Cell Nucleus; Cells, Cultured; Ethanol; Flavonoids; Hepatocytes; Histones; Imidazoles; Male; Mitogen-Activated Protein Kinase Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Serine | 2007 |
Penta-acetyl geniposide-induced apoptosis involving transcription of NGF/p75 via MAPK-mediated AP-1 activation in C6 glioma cells.
Topics: Animals; Anthracenes; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Cell Line, Tumor; Electrophoretic Mobility Shift Assay; Flavonoids; Gardenia; Glioma; Glucosides; Imidazoles; Immunoblotting; Iridoid Glucosides; Iridoids; Keratolytic Agents; Masoprocol; Mitogen-Activated Protein Kinases; Molecular Structure; Nerve Growth Factor; NF-kappa B; Peptide Fragments; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factor AP-1; Transcriptional Activation | 2007 |
Thimerosal-induced apoptosis in human SCM1 gastric cancer cells: activation of p38 MAP kinase and caspase-3 pathways without involvement of [Ca2+]i elevation.
Topics: Anthracenes; Apoptosis; Calcium Signaling; Caspase 3; Cell Line, Tumor; Cell Survival; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Preservatives, Pharmaceutical; Protein Kinase Inhibitors; Pyridines; Stomach Neoplasms; Thimerosal; Time Factors | 2007 |
Expression and function of mixed lineage kinases in dendritic cells.
Topics: Anthracenes; Antigen Presentation; Carbazoles; Dendritic Cells; Humans; Imidazoles; Indoles; Lipopolysaccharides; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Toll-Like Receptors; Zymosan | 2007 |
Interleukin-1beta gene in orange-spotted grouper, Epinephelus coioides: molecular cloning, expression, biological activities and signal transduction.
Topics: Amino Acid Sequence; Animals; Anthracenes; Base Sequence; Cell Proliferation; Cells, Cultured; Cloning, Molecular; Cyclooxygenase 2; DNA, Complementary; Gene Expression Regulation; Imidazoles; Interleukin-1beta; Lipopolysaccharides; MAP Kinase Kinase 4; Molecular Sequence Data; Organ Specificity; p38 Mitogen-Activated Protein Kinases; Perciformes; Phylogeny; Poly I-C; Pyridines; Recombinant Proteins; Signal Transduction | 2008 |
[Regulation of promatrilysin expression by tissue factor/actived coagulation factor VII complex in LoVo colon cancer cell line].
Topics: Anthracenes; Cell Line, Tumor; Colonic Neoplasms; Enzyme Inhibitors; Enzyme Precursors; Factor VII; Flavonoids; Humans; Imidazoles; MAP Kinase Signaling System; Matrix Metalloproteinase 7; Metalloendopeptidases; Pyridines; Thromboplastin | 2007 |
Specific inhibition of basal mitogen-activated protein kinases and phosphatidylinositol 3 kinase activities in leukemia cells: a possible therapeutic role for the kinase inhibitors.
Topics: Anthracenes; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Division; Cell Line, Tumor; Chromones; Drug Screening Assays, Antitumor; Drug Synergism; Flavonoids; Gene Expression Regulation, Leukemic; HL-60 Cells; Humans; Imidazoles; Leukemia; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Monocytes; Morpholines; Neoplasm Proteins; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyridines; U937 Cells | 2008 |
Oridonin induced autophagy in human cervical carcinoma HeLa cells through Ras, JNK, and P38 regulation.
Topics: Adenine; Anthracenes; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Blotting, Western; Cadaverine; Diterpenes; Diterpenes, Kaurane; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Flow Cytometry; HeLa Cells; Humans; Imidazoles; Isodon; JNK Mitogen-Activated Protein Kinases; Membrane Proteins; Microtubule-Associated Proteins; p38 Mitogen-Activated Protein Kinases; Polyenes; Polyunsaturated Alkamides; Pyridines; ras Proteins | 2007 |
Cytochrome P4502E1 sensitizes to tumor necrosis factor alpha-induced liver injury through activation of mitogen-activated protein kinases in mice.
Topics: Animals; Anthracenes; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; Glutathione; Hepatocytes; Imidazoles; Lipopolysaccharides; Liver Diseases; MAP Kinase Kinase 4; Mice; Mice, Knockout; Mitochondria, Liver; Mitochondrial Swelling; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2008 |
Mycoplasma genitalium-derived lipid-associated membrane proteins induce activation of MAPKs, NF-kappaB and AP-1 in THP-1 cells.
Topics: Anthracenes; Bacterial Proteins; Blotting, Western; DNA; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Interleukin-1beta; Interleukin-6; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Monocytes; Mycoplasma genitalium; NF-kappa B; Protein Binding; Pyridines; Pyrrolidines; Thiocarbamates; Time Factors; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2008 |
Involvement of mitogen-activated protein kinases and NFkappaB in LPS-induced CD40 expression on human monocytic cells.
Topics: Animals; Anthracenes; Butadienes; CD40 Antigens; Cell Line; Cell Line, Tumor; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Flow Cytometry; Humans; Imidazoles; Immunoblotting; Leupeptins; Mitogen-Activated Protein Kinases; Monocytes; NF-kappa B; Nitriles; Phosphorylation; Polysaccharides, Bacterial; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Sulfones; Time Factors; Toll-Like Receptor 4 | 2008 |
Phorbol 12-myristate 13-acetate-activated protein kinase C increased migratory activity of subconjunctival fibroblasts via stress-activated protein kinase pathways.
Topics: Actins; Animals; Anthracenes; Cell Movement; Cells, Cultured; Conjunctiva; Enzyme Activation; Fibroblasts; Imidazoles; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Pseudopodia; Pyridines; Rats; Rats, Wistar; Signal Transduction; Tetradecanoylphorbol Acetate | 2007 |
Internalization of Staphylococcus aureus by bovine endothelial cells is associated with the activity state of NF-kappaB and modulated by the pro-inflammatory cytokines TNF-alpha and IL-1beta.
Topics: Animals; Anthracenes; Cattle; Colony Count, Microbial; Endothelial Cells; Enzyme Inhibitors; Female; Imidazoles; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Mastitis, Bovine; Microscopy, Electron; NF-kappa B; Nitriles; Peptides; Pyridines; Staphylococcal Infections; Staphylococcus aureus; Sulfones; Tumor Necrosis Factor-alpha | 2008 |
Role of mitogen-activated protein kinases in the iNOS production and cytokine secretion by Salmonella enterica serovar Typhimurium porins.
Topics: Animals; Anthracenes; Cytokines; Imidazoles; Macrophage Activation; Macrophages; Mice; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitric Oxide Synthase Type II; Porins; Protein Kinase Inhibitors; Pyridines; Salmonella typhimurium | 2008 |
MD-2 controls bacterial lipopolysaccharide hyporesponsiveness in human intestinal epithelial cells.
Topics: Anthracenes; Caco-2 Cells; Cell Line, Tumor; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Flow Cytometry; Gene Expression; HT29 Cells; Humans; Imidazoles; Interleukin-8; Intestines; Lipopolysaccharides; Lymphocyte Antigen 96; Mitogen-Activated Protein Kinases; Monocytes; NF-kappa B; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Toll-Like Receptor 4; Transfection | 2008 |
Inhibition of Src and p38 MAP kinases suppresses the change of claudin expression induced on dedifferentiation of primary cultured parotid acinar cells.
Topics: Amylases; Animals; Anthracenes; Aquaporin 5; Butadienes; Cell Adhesion; Cell Culture Techniques; Cell Differentiation; Cell Proliferation; Cell Shape; Cells, Cultured; Claudin-4; Claudins; Enzyme Activation; Extracellular Matrix; Imidazoles; Keratin-14; Male; Membrane Proteins; Nitriles; p38 Mitogen-Activated Protein Kinases; Parotid Gland; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Pyrimidines; Rats; Rats, Sprague-Dawley; Signal Transduction; src-Family Kinases; Tight Junctions; Time Factors; Vimentin | 2008 |
Transcriptional complex formation of c-Fos, STAT3, and hepatocyte NF-1 alpha is essential for cytokine-driven C-reactive protein gene expression.
Topics: Anthracenes; C-Reactive Protein; Cell Line; Cell Line, Tumor; Cytokines; Gene Expression Regulation; Hepatocyte Nuclear Factor 1-alpha; Humans; Imidazoles; Immunosuppressive Agents; Interleukin-1; Interleukin-6; NF-kappa B; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; Pyridines; STAT3 Transcription Factor; Transcription Factor AP-1; Transcription, Genetic | 2008 |
Involvement of oxidative stress-activated JNK signaling in the methamphetamine-induced cell death of human SH-SY5Y cells.
Topics: Anthracenes; Antioxidants; Apoptosis; Cell Line, Tumor; Central Nervous System Stimulants; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Methamphetamine; Neuroblastoma; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Vitamin E | 2008 |
Anti-fas activating antibody enhances trophoblast outgrowth on endometrial epithelial cells by induction of P38 MAPK/JNK-mediated apoptosis.
Topics: Amino Acid Chloromethyl Ketones; Anthracenes; Antibodies, Monoclonal; Apoptosis; Caspases; Cell Line, Tumor; Cell Proliferation; Coculture Techniques; Cysteine Proteinase Inhibitors; Embryo Implantation; Endometrium; Epithelial Cells; fas Receptor; Female; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Trophoblasts | 2008 |
In vitro, inhibition of mitogen-activated protein kinase pathways protects against bupivacaine- and ropivacaine-induced neurotoxicity.
Topics: Amides; Anesthetics, Local; Animals; Anthracenes; Bupivacaine; Butadienes; Cell Size; Cell Survival; Cells, Cultured; Cytoprotection; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Ganglia, Spinal; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lidocaine; Membrane Potentials; Mitogen-Activated Protein Kinases; Neurons, Afferent; Nitriles; p38 Mitogen-Activated Protein Kinases; Phenotype; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Ropivacaine; Sodium Channels | 2008 |
Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies.
Topics: Amino Acid Sequence; Anthracenes; Argonaute Proteins; Arsenites; Blotting, Western; Cell Line; Eukaryotic Initiation Factor-2; Flavonoids; Glutathione Transferase; Humans; Imidazoles; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Mass Spectrometry; Microscopy, Confocal; Mitogen-Activated Protein Kinase Kinases; Molecular Sequence Data; Mutation; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Recombinant Proteins; Sequence Homology, Amino Acid; Serine; Sodium Compounds | 2008 |
Egr-1 mRNA induction by medium flow involves mRNA stabilization and is enhanced by the p38 inhibitor SB203580 in osteoblast-like cells.
Topics: Animals; Anthracenes; Butadienes; Cells, Cultured; Early Growth Response Protein 1; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Imidazoles; MAP Kinase Kinase 4; Mechanotransduction, Cellular; Mice; Nitriles; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Protein Kinase Inhibitors; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transfection | 2008 |
7-Ketocholesterol upregulates interleukin-6 via mechanisms that are distinct from those of tumor necrosis factor-alpha, in vascular smooth muscle cells.
Topics: Animals; Anthracenes; Brefeldin A; CCAAT-Enhancer-Binding Proteins; Cells, Cultured; Dactinomycin; ELAV Proteins; Humans; Imidazoles; Interleukin-6; Ketocholesterols; Muscle, Smooth, Vascular; NF-kappa B; Pyridines; Rats; RNA, Messenger; Tumor Necrosis Factor-alpha; Up-Regulation | 2009 |
TLR4 signaling induces B7-H1 expression through MAPK pathways in bladder cancer cells.
Topics: Anthracenes; Antigens, CD; B7-H1 Antigen; Carcinoma, Transitional Cell; Cell Line, Tumor; Chromones; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharide Receptors; Lipopolysaccharides; MAP Kinase Signaling System; Morpholines; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Pyridines; Toll-Like Receptor 4; Up-Regulation; Urinary Bladder Neoplasms | 2008 |
Pharmacological inhibitors of JNK and ERK kinases SP600125 and U0126 are not appropriate tools for studies of drug metabolism because they activate aryl hydrocarbon receptor.
Topics: Anthracenes; Butadienes; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Extracellular Signal-Regulated MAP Kinases; Hepatocytes; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Pharmaceutical Preparations; Pyridines; Receptors, Aryl Hydrocarbon | 2008 |
Lipopolysaccharide (LPS) of Porphyromonas gingivalis induces IL-1beta, TNF-alpha and IL-6 production by THP-1 cells in a way different from that of Escherichia coli LPS.
Topics: Anthracenes; Cell Line; Enzyme Inhibitors; Escherichia coli; Humans; Imidazoles; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; MAP Kinase Kinase 4; Monocytes; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Peptides; Porphyromonas gingivalis; Pyridines; Toll-Like Receptor 2; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2008 |
Involvement of the PI3K/Akt pathway in estrogen-mediated regulation of human CYP7B1: identification of CYP7B1 as a novel target for PI3K/Akt and MAPK signalling.
Topics: Anthracenes; Base Sequence; Cell Line, Tumor; Chromones; Cytochrome P450 Family 7; Elafin; Enzyme Activation; Estradiol; Estrogens; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; MAP Kinase Signaling System; Molecular Sequence Data; Morpholines; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; Pyridines; Steroid Hydroxylases | 2008 |
Interferon-gamma priming is involved in the activation of arginase by oligodeoxinucleotides containing CpG motifs in murine macrophages.
Topics: Animals; Anthracenes; Antiviral Agents; Arginase; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; GC Rich Sequence; Imidazoles; Interferon-gamma; Interleukin-10; Interleukin-12; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred BALB C; Nitric Oxide Synthase Type II; Oligodeoxyribonucleotides; p38 Mitogen-Activated Protein Kinases; Pyridines; Up-Regulation | 2009 |
Enhanced induction of LPS-induced fibroblast MCP-1 by interferon-gamma: involvement of JNK and MAPK phosphatase-1.
Topics: Animals; Anthracenes; Cells, Cultured; Chemokine CCL2; Dual Specificity Phosphatase 1; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Humans; Imidazoles; Interferon-gamma; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; MAP Kinase Signaling System; Mice; NF-kappa B; Nitric Oxide; Pyridines; STAT1 Transcription Factor | 2009 |
AP-1 and ERK1 but not p38 nor JNK is required for CRPV early protein 2-dependent MMP-9 promoter activation in rabbit epithelial cells.
Topics: Animals; Anthracenes; Binding Sites; Carcinoma; Cell Line; Cell Line, Tumor; Cottontail rabbit papillomavirus; Disease Models, Animal; DNA Mutational Analysis; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 3; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Pyridines; Rabbits; Signal Transduction; Transcription Factor AP-1; Transcription Factors; Viral Proteins | 2009 |
Effect of curcumin on acidic pH-induced expression of IL-6 and IL-8 in human esophageal epithelial cells (HET-1A): role of PKC, MAPKs, and NF-kappaB.
Topics: Anthracenes; Anti-Inflammatory Agents; Benzophenanthridines; Cell Line; Curcumin; Enzyme Activation; Epithelial Cells; Esophagus; Flavonoids; Humans; Hydrogen-Ion Concentration; Imidazoles; Interleukin-6; Interleukin-8; Mitogen-Activated Protein Kinases; Mucous Membrane; NF-kappa B; Peptides; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Telomerase; Time Factors; Transcription, Genetic; Up-Regulation | 2009 |
Neuronal injury induces cytokine-induced neutrophil chemoattractant-1 (CINC-1) production in astrocytes.
Topics: Animals; Anthracenes; Astrocytes; Butadienes; Cells, Cultured; Cerebral Cortex; Chemokine CXCL1; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Imidazoles; Immunochemistry; Mitogen-Activated Protein Kinases; N-Methylaspartate; Neurons; Nitriles; Pyridines; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2009 |
Apoptosis induction by oxidized glycated LDL in human retinal capillary pericytes is independent of activation of MAPK signaling pathways.
Topics: Anthracenes; Apoptosis; Butadienes; Capillaries; Extracellular Signal-Regulated MAP Kinases; Glycation End Products, Advanced; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipoproteins, LDL; MAP Kinase Signaling System; Nitriles; p38 Mitogen-Activated Protein Kinases; Pericytes; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Retinal Vessels; Time Factors | 2009 |
TNF-alpha reduces the level of Staphylococcus epidermidis internalization by bovine endothelial cells.
Topics: Animals; Anthracenes; Cattle; Colony Count, Microbial; Cytoplasm; Endothelial Cells; Imidazoles; Immunologic Factors; MAP Kinase Kinase 4; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Peptides; Pyridines; Staphylococcus epidermidis; Sulfones; Tumor Necrosis Factor-alpha | 2009 |
Tumour necrosis factor alpha stimulates the production of monocyte chemoattractants by extravillous trophoblast cells via differential activation of MAPK pathways.
Topics: Anthracenes; Butadienes; Cell Line; Cell Movement; Chemokine CCL2; Chemokine CCL5; Collagen; Culture Media, Conditioned; Drug Combinations; Enzyme Inhibitors; Female; Humans; Imidazoles; In Vitro Techniques; Laminin; Macrophages; MAP Kinase Signaling System; Monocytes; Nitriles; Pregnancy; Proteoglycans; Pyridines; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Trophoblasts; Tumor Necrosis Factor-alpha | 2009 |
Involvement of regulatory elements on corticotropin-releasing factor gene promoter in hypothalamic 4B cells.
Topics: Anthracenes; Cell Line; Chromones; Colforsin; Corticotropin-Releasing Hormone; Dexamethasone; Flavonoids; Genes, Reporter; Humans; Hypothalamus; Imidazoles; Isoquinolines; Morpholines; Promoter Regions, Genetic; Protein Kinase Inhibitors; Pyridines; Regulatory Elements, Transcriptional; Sequence Deletion; Sulfonamides; Transfection | 2008 |
Endogenous IGFBP-3 is required for both growth factor-stimulated cell proliferation and cytokine-induced apoptosis in mammary epithelial cells.
Topics: Animals; Anisomycin; Anthracenes; Apoptosis; Cattle; Cell Line; Cell Proliferation; DNA Replication; Enzyme Activation; Epithelial Cells; Female; Imidazoles; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; JNK Mitogen-Activated Protein Kinases; Mammary Glands, Animal; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; RNA Interference; RNA, Messenger; RNA, Small Interfering; Time Factors; Tumor Necrosis Factor-alpha; Up-Regulation | 2009 |
Trans-Zeatin inhibits UVB-induced matrix metalloproteinase-1 expression via MAP kinase signaling in human skin fibroblasts.
Topics: Anthracenes; Blotting, Western; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Flavonoids; Humans; Imidazoles; Infant, Newborn; MAP Kinase Signaling System; Matrix Metalloproteinase 1; Mitogen-Activated Protein Kinases; Plant Growth Regulators; Pyridines; Skin; Ultraviolet Rays; Zeatin | 2009 |
Upregulation of proinflammatory cytokines and NO production in BV-activated avian macrophage-like cell line (HD11) requires MAPK and NF-kappaB pathways.
Topics: Animals; Anthracenes; Birds; Cell Line; DNA Virus Infections; Imidazoles; Immunity, Innate; Interferon-gamma; Interleukin-12 Subunit p40; Macrophage Activation; Macrophages; MAP Kinase Kinase 4; MAP Kinase Signaling System; Moths; Nitric Oxide; Nitriles; Nucleopolyhedroviruses; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Sulfones; Virulence | 2009 |
Effects of polychlorinated biphenyls on the neutrophil NADPH oxidase system.
Topics: Anthracenes; Aroclors; Butadienes; Cyclosporine; Environmental Pollutants; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Luminescent Measurements; NADPH Oxidases; Neutrophil Activation; Neutrophils; Nitriles; Pyridines; Respiratory Burst; Tacrolimus | 2009 |
NADPH oxidase and ERK1/2 are involved in cadmium induced-STAT3 activation in HepG2 cells.
Topics: Allopurinol; Anthracenes; Blotting, Western; Cadmium; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; Liver; NADPH Oxidases; Onium Compounds; Phosphorylation; Potassium Cyanide; Pyridines; Signal Transduction; STAT3 Transcription Factor; Sulfones | 2009 |
Arecoline-stimulated connective tissue growth factor production in human buccal mucosal fibroblasts: Modulation by curcumin.
Topics: Anthracenes; Anti-Inflammatory Agents, Non-Steroidal; Arecoline; Cheek; Cholinergic Agonists; Connective Tissue Growth Factor; Curcumin; Endothelial Cells; Epithelial Cells; Fibroblasts; Flavonoids; Humans; Imidazoles; Mouth Mucosa; Nitriles; Oral Submucous Fibrosis; Pyridines; Sulfones | 2009 |
PHR regulates growth cone pausing at intermediate targets through microtubule disassembly.
Topics: Animals; Anthracenes; Apoptosis Regulatory Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Death-Associated Protein Kinases; Dose-Response Relationship, Drug; Electroporation; Enzyme Inhibitors; Gene Expression Regulation; Green Fluorescent Proteins; Growth Cones; Imidazoles; MAP Kinase Kinase 4; Membrane Proteins; Mice; Mice, Transgenic; Microtubules; Neurons; Nocodazole; Paclitaxel; Phosphorylation; Prosencephalon; Pyridines; Signal Transduction; Spinal Cord; Tubulin Modulators; Zebrafish; Zebrafish Proteins | 2009 |
Biphasic effect of cadmium on cell proliferation in human embryo lung fibroblast cells and its molecular mechanism.
Topics: Anthracenes; Cadmium; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Fibroblasts; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lung; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Pyridines | 2009 |
Acetaminophen and lipopolysaccharide act in synergy for the production of pro-inflammatory cytokines in murine RAW264.7 macrophages.
Topics: Acetaminophen; Animals; Anthracenes; Cell Line; Cytochrome P-450 CYP1A2 Inhibitors; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; Indomethacin; Interleukin-1beta; Lipopolysaccharides; Macrophages; MAP Kinase Kinase 1; MAP Kinase Kinase 4; Mice; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines; Signal Transduction; Theophylline; Tumor Necrosis Factor-alpha | 2009 |
Effects of prostaglandin D2 on Na-dependent phosphate transport activity and its intracellular signaling mechanism in osteoblast-like cells.
Topics: 3T3 Cells; Animals; Anthracenes; Butadienes; Cells, Cultured; Chromones; Dose-Response Relationship, Drug; Imidazoles; Mice; Morpholines; Naphthalenes; Nitriles; Osteoblasts; Phosphates; Prostaglandin D2; Pyridines; Signal Transduction; Sirolimus; Sodium | 2009 |
Inhibition of the JNK signalling pathway enhances proteasome inhibitor-induced apoptosis of kidney cancer cells by suppression of BAG3 expression.
Topics: Adaptor Proteins, Signal Transducing; Anthracenes; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Kidney Neoplasms; Leupeptins; Mitogen-Activated Protein Kinase 8; p38 Mitogen-Activated Protein Kinases; Proteasome Inhibitors; Pyridines; Signal Transduction | 2009 |
TAK1-mediated serine/threonine phosphorylation of epidermal growth factor receptor via p38/extracellular signal-regulated kinase: NF-{kappa}B-independent survival pathways in tumor necrosis factor alpha signaling.
Topics: Anthracenes; Butadienes; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Imidazoles; Lactones; MAP Kinase Kinase Kinases; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Quinazolines; Resorcinols; RNA, Small Interfering; Serine; Signal Transduction; Threonine; Tumor Necrosis Factor-alpha | 2009 |
Regulation of Lhb and Egr1 gene expression by GNRH pulses in rat pituitaries is both c-Jun N-terminal kinase (JNK)- and extracellular signal-regulated kinase (ERK)-dependent.
Topics: Analysis of Variance; Animals; Anthracenes; Blotting, Western; Cells, Cultured; Early Growth Response Protein 1; Enzyme Inhibitors; Female; Flavonoids; Gonadotropin-Releasing Hormone; Imidazoles; JNK Mitogen-Activated Protein Kinases; Luteinizing Hormone, beta Subunit; Male; MAP Kinase Kinase 1; Neoplasm Proteins; Phosphorylation; Pituitary Gland; Pyridines; Rats; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors | 2009 |
Genistein inhibits cell growth by modulating various mitogen-activated protein kinases and AKT in cervical cancer cells.
Topics: Androstadienes; Anthracenes; Anticarcinogenic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Flavonoids; Genistein; HeLa Cells; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Uterine Cervical Neoplasms; Wortmannin | 2009 |
Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2.
Topics: Animals; Animals, Newborn; Anthracenes; Antibiotics, Antineoplastic; Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Cells, Cultured; Cellular Senescence; Checkpoint Kinase 2; Cytoskeleton; Dose-Response Relationship, Drug; Doxorubicin; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitosis; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Phenotype; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Pyridines; Rats; Rats, Sprague-Dawley; RNA Interference; Telomeric Repeat Binding Protein 1; Telomeric Repeat Binding Protein 2; Time Factors; Toluene; Tumor Suppressor Protein p53 | 2009 |
Enterobacter sakazakii targets DC-SIGN to induce immunosuppressive responses in dendritic cells by modulating MAPKs.
Topics: Animals; Anthracenes; Bacterial Outer Membrane Proteins; Butadienes; Cell Adhesion Molecules; Cell Survival; Cronobacter sakazakii; Dendritic Cells; Enterobacteriaceae Infections; Enzyme Inhibitors; Epithelial Cells; Flavonoids; HeLa Cells; Humans; Imidazoles; Interleukin-10; Lectins, C-Type; Lipopolysaccharides; Lymphocyte Activation; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Mitogen-Activated Protein Kinase Kinases; Nitriles; Pyridines; Rats; Receptors, Cell Surface; Transfection; Transforming Growth Factor beta | 2009 |
The proliferation and migration effects of huangqi on RSC96 Schwann cells.
Topics: Animals; Anthracenes; Astragalus Plant; Astragalus propinquus; Blotting, Western; Butadienes; Cell Line; Cell Movement; Cell Proliferation; Cell Survival; Cyclin A; Cyclin D1; Cyclin E; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Inhibitors; Fibroblast Growth Factor 2; Imidazoles; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 3; Models, Biological; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Schwann Cells; Urokinase-Type Plasminogen Activator | 2009 |
HMGB1 enhances the proinflammatory activity of lipopolysaccharide by promoting the phosphorylation of MAPK p38 through receptor for advanced glycation end products.
Topics: Animals; Anthracenes; Arthritis, Experimental; Cytokines; Enzyme Inhibitors; Female; Flavonoids; Glycation End Products, Advanced; HMGB1 Protein; Imidazoles; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Toll-Like Receptor 2; Toll-Like Receptor 4; Up-Regulation | 2009 |
The role of p38 mitogen-activated protein kinase in serum-induced leukemia inhibitory factor secretion by bone marrow stromal cells from pediatric myelodysplastic syndromes.
Topics: Anthracenes; Bone Marrow Cells; Cells, Cultured; Child; Child, Preschool; Female; Flavonoids; Humans; Imidazoles; Infant; Leukemia Inhibitory Factor; Male; Myelodysplastic Syndromes; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Serum; Stromal Cells | 2010 |
Ligand-independent activation of the androgen receptor by insulin-like growth factor-I and the role of the MAPK pathway in skeletal muscle cells.
Topics: Active Transport, Cell Nucleus; Animals; Anthracenes; Cell Line; Cell Nucleus; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; Insulin-Like Growth Factor I; Ligands; MAP Kinase Kinase 4; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Androgen; Signal Transduction | 2009 |
[Pathogenetic role of tissue factor in endothelial-injury in graft-versus-host disease].
Topics: Animals; Anthracenes; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Endothelium; Endothelium, Vascular; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Imidazoles; Interferon-gamma; Interleukin-6; Mice; Mitogen-Activated Protein Kinases; Pyridines; T-Lymphocytes; Thromboplastin; Tumor Necrosis Factor-alpha | 2009 |
Close association of p38 and JNK with plasminogen-dependent upregulation of PAI-1 in rat astrocytes in vitro.
Topics: Animals; Anthracenes; Astrocytes; Cells, Cultured; Imidazoles; JNK Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Plasminogen; Plasminogen Activator Inhibitor 1; Pyridines; Rats; Up-Regulation | 2010 |
Mycophenolic acid attenuates tumor necrosis factor-alpha-induced endothelin-1 production in human aortic endothelial cells.
Topics: Acetylcysteine; Anthracenes; Cells, Cultured; Endothelin-1; Endothelium, Vascular; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mycophenolic Acid; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2010 |
Palmitic acid promotes endothelial progenitor cells apoptosis via p38 and JNK mitogen-activated protein kinase pathways.
Topics: Anthracenes; Apoptosis; Blotting, Western; Caspase 3; Cells, Cultured; Endothelial Cells; Flavonoids; Flow Cytometry; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Palmitic Acid; Pyridines; Stem Cells; Up-Regulation | 2010 |
Deferoxamine mesylate is toxic for retinal pigment epithelium cells in vitro, and its toxicity is mediated by p38.
Topics: Animals; Anthracenes; Blotting, Western; Butadienes; Cell Death; Cells, Cultured; Deferoxamine; Dose-Response Relationship, Drug; Hydrogen Peroxide; Imidazoles; Iron Chelating Agents; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Retinal Pigment Epithelium; Swine; Trypan Blue | 2010 |
Helicobacter pylori induces ERK-dependent formation of a phospho-c-Fos c-Jun activator protein-1 complex that causes apoptosis in macrophages.
Topics: Animals; Anthracenes; Apoptosis; Cell Line; Cell Nucleus; Cell Survival; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Fluorescence Resonance Energy Transfer; Helicobacter Infections; Helicobacter pylori; Host-Pathogen Interactions; Imidazoles; Immunoblotting; Macromolecular Substances; Macrophages; Mice; Mice, Inbred C57BL; Ornithine Decarboxylase; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor AP-1 | 2010 |
Impaired dephosphorylation renders G6PD-knockdown HepG2 cells more susceptible to H(2)O(2)-induced apoptosis.
Topics: Acetylcysteine; Anthracenes; Apoptosis; Dual Specificity Phosphatase 1; Flavonoids; Gene Knockdown Techniques; Glucosephosphate Dehydrogenase; Hep G2 Cells; Humans; Hydrogen Peroxide; Imidazoles; Mitogen-Activated Protein Kinases; Protein Tyrosine Phosphatases; Pyridines | 2010 |
PAI-1-derived peptide EEIIMD prevents impairment of cerebrovasodilation by augmenting p38 MAPK upregulation after cerebral hypoxia/ischemia.
Topics: Animals; Animals, Newborn; Anthracenes; Blood Pressure; Carbon Dioxide; Cardiovascular Agents; Cerebrovascular Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Female; Hypercapnia; Hypotension; Hypoxia-Ischemia, Brain; Imidazoles; Injections, Intravenous; Isoproterenol; JNK Mitogen-Activated Protein Kinases; Male; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pia Mater; Protein Kinase Inhibitors; Pyridines; Swine; Time Factors; Up-Regulation; Vasodilation; Vasodilator Agents | 2010 |
Deciphering mechanisms controlling placental artery endothelial cell migration stimulated by vascular endothelial growth factor.
Topics: Androstadienes; Animals; Anthracenes; Arteries; Butadienes; Caveolin 1; Cell Movement; Cells, Cultured; CSK Tyrosine-Protein Kinase; Electrophoresis, Polyacrylamide Gel; Endothelial Cells; Enzyme Inhibitors; Female; Focal Adhesion Protein-Tyrosine Kinases; Imidazoles; Immunoprecipitation; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitric Oxide Synthase Type III; Nitriles; Nitrogen Oxides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Placenta; Pregnancy; Protein-Tyrosine Kinases; Pyridines; Pyrimidines; Sheep; Signal Transduction; src-Family Kinases; Vascular Endothelial Growth Factor A; Wortmannin | 2010 |
Proinflammatory effects of muramyldipeptide on human gingival fibroblasts.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adult; Anthracenes; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chemokine CCL2; Chemokine CXCL10; Chemokine CXCL11; Chromones; Chronic Periodontitis; Enzyme Inhibitors; Female; Fibroblasts; Flavonoids; Gingiva; Humans; Imidazoles; Inflammation Mediators; Interferon-gamma; Interleukin-6; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Male; Middle Aged; Morpholines; Nod2 Signaling Adaptor Protein; Periodontal Attachment Loss; Periodontal Pocket; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Tumor Necrosis Factor-alpha | 2010 |
Novel plasminogen activator inhibitor-1-derived peptide protects against impairment of cerebrovasodilation after photothrombosis through inhibition of JNK MAPK.
Topics: Animals; Animals, Newborn; Anthracenes; Cerebrovascular Circulation; Disease Models, Animal; Erythrosine; Female; Fibrinolytic Agents; Imidazoles; Intracranial Thrombosis; JNK Mitogen-Activated Protein Kinases; Lasers, Solid-State; Male; p38 Mitogen-Activated Protein Kinases; Peptides; Protein Kinase Inhibitors; Pyridines; Recombinant Proteins; Swine; Time Factors; Tissue Plasminogen Activator; Vasoconstriction; Vasodilation | 2010 |
Negative modulation of invariant natural killer T cell responses to glycolipid antigens by p38 MAP kinase.
Topics: Animals; Anthracenes; Antibodies; Antigen Presentation; Antigens; Antigens, CD1d; CD3 Complex; Cytokines; Down-Regulation; Enzyme Inhibitors; Flavonoids; Galactosylceramides; Imidazoles; Interferon-gamma; Interleukin-2; Interleukin-4; Mice; Mice, Inbred C57BL; Natural Killer T-Cells; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Receptors, Antigen, T-Cell; Spleen | 2010 |
Stimulation of pro-inflammatory responses by mebendazole in human monocytic THP-1 cells through an ERK signaling pathway.
Topics: Anthracenes; Antinematodal Agents; Cell Line, Tumor; Cells, Cultured; Chemokines; Cytokines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; Interleukin-8; Mebendazole; Mitogen-Activated Protein Kinases; Monocytes; Pyridines; Tumor Necrosis Factor-alpha | 2011 |
Constitutive MEK1 activation rescues anthrax lethal toxin-induced vascular effects in vivo.
Topics: Animals; Animals, Genetically Modified; Anthracenes; Anthrax; Antigens, Bacterial; Bacillus anthracis; Bacterial Toxins; Blotting, Western; Capillary Permeability; Enzyme Activation; Enzyme Inhibitors; Host-Pathogen Interactions; Humans; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Phenotype; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, Protein; Zebrafish; Zebrafish Proteins | 2010 |
Modulation of ROS/MAPK signaling pathways by okadaic acid leads to cell death via, mitochondrial mediated caspase-dependent mechanism.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Anthracenes; Apoptosis; Apoptosis Inducing Factor; Blotting, Western; Caspase 3; Caspase 7; Caspase 9; Cell Line, Tumor; Cyclosporins; Cytochromes c; DNA Damage; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glutathione; Humans; Imidazoles; Immunoblotting; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerases; Pyridines; Reactive Oxygen Species; U937 Cells | 2011 |
[Simvastatin suppress lipopolysaccharides induced upregulation of lipoprotein associated phospholipase A(2) expression in macrophages via inactivation of p38MAPK pathway].
Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Anthracenes; Butadienes; Cells, Cultured; Humans; Imidazoles; Lipopolysaccharides; Macrophages; Monocytes; Nitriles; p38 Mitogen-Activated Protein Kinases; Phospholipases A2; Phosphorylation; Pyridines; RNA, Messenger; Simvastatin | 2010 |
[Role of MAPK in the migration of human coronary artery smooth muscle cell into three-dimensional fibrin gel].
Topics: Anthracenes; Cell Movement; Cells, Cultured; Coronary Vessels; Extracellular Signal-Regulated MAP Kinases; Fibrin; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Pyridines | 2005 |
Apoptosis induced by a new flavonoid in human hepatoma HepG2 cells involves reactive oxygen species-mediated mitochondrial dysfunction and MAPK activation.
Topics: Acetylcysteine; Anthracenes; Apoptosis; Carcinoma, Hepatocellular; Caspases; Cell Survival; Cyclohexanones; Enzyme Activation; Flavones; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Imidazoles; Intracellular Space; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reactive Oxygen Species | 2011 |
Roles of mitogen-activated protein kinases in the modulation of endothelial cell function following thermal injury.
Topics: Actin Cytoskeleton; Animals; Anthracenes; Burns; Chemokine CCL2; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; Intercellular Adhesion Molecule-1; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; P-Selectin; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Tight Junctions | 2011 |
Dermal fibroblasts influence the expression profile of 14-3-3 proteins in human keratinocytes.
Topics: 14-3-3 Proteins; Anthracenes; Biomarkers, Tumor; Blotting, Western; Cells, Cultured; Coculture Techniques; Culture Media, Conditioned; Dermis; Exonucleases; Exoribonucleases; Fibroblasts; Flavonoids; Gene Expression Profiling; Humans; Imidazoles; Keratinocytes; MAP Kinase Signaling System; Pyridines; Reverse Transcriptase Polymerase Chain Reaction | 2011 |
Angiotensin II type 1 receptor signalling regulates microRNA differentially in cardiac fibroblasts and myocytes.
Topics: Angiotensin II; Anthracenes; Butadienes; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Gene Expression Profiling; Gene Expression Regulation; GTP-Binding Protein alpha Subunits, Gq-G11; HEK293 Cells; Humans; Imidazoles; MicroRNAs; Myocytes, Cardiac; Nitriles; Pyridines; Receptor, Angiotensin, Type 1; Signal Transduction | 2011 |
Attenuated expression and function of the RECK tumor suppressor under hypoxic conditions is mediated by the MAPK signaling pathways.
Topics: Anthracenes; Cell Hypoxia; Cell Line, Tumor; Down-Regulation; Flavonoids; GPI-Linked Proteins; HEK293 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Mitogen-Activated Protein Kinases; Neoplasms; Promoter Regions, Genetic; Protein Binding; Pyridines; Response Elements; RNA, Messenger; Signal Transduction | 2011 |
Imatinib mesylate induction of ROS-dependent apoptosis in melanoma B16F0 cells.
Topics: Animals; Anthracenes; Antineoplastic Agents; Apoptosis; Benzamides; Flavonoids; Flow Cytometry; Imatinib Mesylate; Imidazoles; Melanoma, Experimental; Membrane Potentials; Mice; Mitochondria; Piperazines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Reactive Oxygen Species | 2011 |
c-Jun NH₂-terminal kinase contributes to dexmedetomidine-induced contraction in isolated rat aortic smooth muscle.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Anthracenes; Aorta; Dexmedetomidine; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; In Vitro Techniques; JNK Mitogen-Activated Protein Kinases; Male; Muscle Contraction; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Protein Isoforms; Pyridines; Rats; Rats, Sprague-Dawley | 2011 |
Suppression of MMP-2 attenuates TNF-α induced NF-κB activation and leads to JNK mediated cell death in glioma.
Topics: Animals; Anthracenes; Apoptosis; Blotting, Western; Cell Line, Tumor; Electrophoresis, Polyacrylamide Gel; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Flow Cytometry; Glioma; Humans; Imidazoles; Immunohistochemistry; Immunoprecipitation; In Situ Nick-End Labeling; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 2; Mice; NF-kappa B; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Tissue Inhibitor of Metalloproteinase-3; Tumor Necrosis Factor-alpha | 2011 |
Enhanced phosphorylation of MAPKs by NE promotes TNF-α production by macrophage through α adrenergic receptor.
Topics: Adrenergic alpha-Antagonists; Animals; Anthracenes; Butadienes; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Nitriles; Norepinephrine; p38 Mitogen-Activated Protein Kinases; Phentolamine; Phosphorylation; Pyridines; Receptors, Adrenergic, alpha; Tumor Necrosis Factor-alpha | 2012 |
Effects of downregulation of aquaporin1 by peptidoglycan and lipopolysaccharide via MAPK pathways in MeT-5A cells.
Topics: Anthracenes; Aquaporin 1; Cell Line; Down-Regulation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Lipopolysaccharides; Mitogen-Activated Protein Kinases; Peptidoglycan; Pyridines; Staphylococcus aureus | 2011 |
tPA contributes to impaired NMDA cerebrovasodilation after traumatic brain injury through activation of JNK MAPK.
Topics: Animals; Animals, Newborn; Anthracenes; Brain Injuries; Butadienes; Drug Interactions; Female; Imidazoles; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; N-Methylaspartate; Nitriles; Oligopeptides; Papaverine; Peptides; Pia Mater; Pyridines; Swine; Tissue Plasminogen Activator; Up-Regulation; Vasoconstriction; Vasodilation | 2011 |
IL-33 is induced by amyloid-β stimulation and regulates inflammatory cytokine production in retinal pigment epithelium cells.
Topics: Amyloid beta-Peptides; Anthracenes; Butadienes; Cell Line; Humans; Imidazoles; Inflammation; Interleukin-1 Receptor-Like 1 Protein; Interleukin-1beta; Interleukin-33; Interleukin-6; Interleukin-8; Interleukins; JNK Mitogen-Activated Protein Kinases; Macular Degeneration; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Nitriles; Peptide Fragments; Pyridines; Receptors, Cell Surface; Retinal Pigment Epithelium; Sulfones; Tumor Necrosis Factor-alpha | 2012 |
Ethanol extract of Prunella vulgaris var. lilacina inhibits HMGB1 release by induction of heme oxygenase-1 in LPS-activated RAW 264.7 cells and CLP-induced septic mice.
Topics: Animals; Anthracenes; Cecum; Cell Line; Cell Survival; Chromones; Cyclooxygenase 2; Disease Models, Animal; Drug Evaluation, Preclinical; Enzyme Activation; Enzyme Induction; Ethanol; Flavonoids; Flowers; Genetic Vectors; Heme Oxygenase-1; HMGB1 Protein; Imidazoles; Lipopolysaccharides; Lung; Macrophages; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Morpholines; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide Synthase Type II; Plant Extracts; Protein Transport; Prunella; Pyridines; Sepsis; Signal Transduction; Transfection | 2012 |
The Ebolavirus VP24 protein blocks phosphorylation of p38 mitogen-activated protein kinase.
Topics: Activating Transcription Factor 4; Anthracenes; Ebolavirus; Enzyme Inhibitors; HEK293 Cells; Humans; Imidazoles; Interferon-beta; JNK Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Signal Transduction; Viral Proteins | 2011 |
Prostaglandin E2 enhances interleukin-8 production via EP4 receptor in human pulmonary microvascular endothelial cells.
Topics: Acute Lung Injury; Anthracenes; Butadienes; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Endothelial Cells; Humans; Imidazoles; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Lung; MAP Kinase Signaling System; Methyl Ethers; Microvessels; Naphthalenes; Neutrophils; Nitriles; p38 Mitogen-Activated Protein Kinases; Phenylbutyrates; Pyridines; Receptors, Prostaglandin E, EP4 Subtype; Respiratory Distress Syndrome; RNA, Messenger; Thionucleotides | 2012 |
Role of c-Jun N-terminal kinase and p38/activation protein-1 in interleukin-1β-mediated type I collagen synthesis in rat hepatic stellate cells.
Topics: Animals; Anthracenes; Blotting, Western; Cell Line; Cell Survival; Collagen Type I; Electrophoretic Mobility Shift Assay; Hepatic Stellate Cells; Imidazoles; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Liver Cirrhosis; Protein Kinase Inhibitors; Pyridines; Rats; Signal Transduction; Transcription Factor AP-1 | 2012 |
Nicotine stimulates urokinase-type plasminogen activator receptor expression and cell invasiveness through mitogen-activated protein kinase and reactive oxygen species signaling in ECV304 endothelial cells.
Topics: Anthracenes; Endothelial Cells; Flavonoids; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; NF-kappa B; Nicotine; Protein Kinase Inhibitors; Pyridines; Reactive Oxygen Species; Receptors, Urokinase Plasminogen Activator; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factor AP-1 | 2012 |
Dynamics and regulation of lipid droplet formation in lipopolysaccharide (LPS)-stimulated microglia.
Topics: Animals; Anthracenes; Blotting, Western; Cells, Cultured; Chromones; Cytoplasmic Granules; Enzyme Activation; Enzyme Inhibitors; Group IV Phospholipases A2; Imidazoles; JNK Mitogen-Activated Protein Kinases; Kinetics; Lipids; Lipopolysaccharides; Membrane Proteins; Mice; Microglia; Microscopy, Confocal; Models, Biological; Morpholines; Oleic Acid; p38 Mitogen-Activated Protein Kinases; Perilipin-2; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Time Factors; Triglycerides | 2012 |
miR-16 targets transcriptional corepressor SMRT and modulates NF-kappaB-regulated transactivation of interleukin-8 gene.
Topics: Anthracenes; Cells, Cultured; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Interleukin-8; Lipopolysaccharides; MAP Kinase Signaling System; MicroRNAs; NF-kappa B; Nuclear Receptor Co-Repressor 2; Pyridines; Transcription, Genetic; Transcriptional Activation; U937 Cells | 2012 |
Activation of JNK signaling mediates connective tissue growth factor expression and scar formation in corneal wound healing.
Topics: Animals; Anthracenes; Cell Line, Transformed; Cicatrix; Collagen Type I; Connective Tissue Growth Factor; Cornea; Corneal Stroma; Enzyme Activation; Eye Injuries, Penetrating; Fibroblasts; Fibronectins; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Phosphorylation; Pyridines; Rats; Rats, Wistar; Telomerase; Transforming Growth Factor beta1; Wound Healing | 2012 |
Lipopolysaccharide enhances decorin expression through the Toll-like receptor 4, myeloid differentiating factor 88, nuclear factor-kappa B, and mitogen-activated protein kinase pathways in odontoblast cells.
Topics: Animals; Anthracenes; Blotting, Western; Butadienes; Cell Line; Decorin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; I-kappa B Kinase; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Luciferases; Luminescent Agents; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Myeloid Differentiation Factor 88; NF-kappa B p50 Subunit; Nitriles; Odontoblasts; p38 Mitogen-Activated Protein Kinases; Pyridines; Real-Time Polymerase Chain Reaction; Time Factors; Toll-Like Receptor 2; Toll-Like Receptor 4; Up-Regulation | 2012 |
EGCG blocks TGFβ1-induced CCN2 by suppressing JNK and p38 in buccal fibroblasts.
Topics: Anthracenes; Benzamides; Catechin; Cell Line; Cells, Cultured; Connective Tissue Growth Factor; Dinoprostone; Dioxoles; Dose-Response Relationship, Drug; Fibroblasts; Flavonoids; Humans; Imidazoles; Lung; MAP Kinase Kinase 4; Mouth Mucosa; Oral Submucous Fibrosis; p38 Mitogen-Activated Protein Kinases; Protease Inhibitors; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2013 |
Regulation of cytokine and chemokine expression by the ribotoxic stress response elicited by Shiga toxin type 1 in human macrophage-like THP-1 cells.
Topics: Anthracenes; Cell Line, Tumor; Chemokines; Cytokines; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Macrophages; Mitogen-Activated Protein Kinase Kinases; Pyridines; Shiga Toxin 1; Stress, Physiological; Time Factors | 2012 |
Tumor necrosis factor-α and interleukin-1β expression pathway induced by Streptococcus mutans in macrophage cell line RAW 264.7.
Topics: Animals; Anthracenes; Antioxidants; Cell Line; Enzyme Activation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases; Imidazoles; Inflammation Mediators; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Macrophages; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; NF-kappa B p50 Subunit; p38 Mitogen-Activated Protein Kinases; Pyridines; Pyrrolidines; Real-Time Polymerase Chain Reaction; Streptococcus mutans; Thiocarbamates; Time Factors; Toll-Like Receptor 2; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2012 |
Mitogen-activated protein kinase pathways are involved in the upregulation of calcitonin gene-related peptide of rat trigeminal ganglion after organ culture.
Topics: Animals; Anthracenes; Calcitonin Gene-Related Peptide; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Migraine Disorders; Neurons; Organ Culture Techniques; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Trigeminal Ganglion; Tumor Necrosis Factor-alpha; Up-Regulation | 2012 |
Protective effect of Homer 1a on tumor necrosis factor-α with cycloheximide-induced apoptosis is mediated by mitogen-activated protein kinase pathways.
Topics: Adrenal Gland Neoplasms; Animals; Anthracenes; Apoptosis; Brain-Derived Neurotrophic Factor; Carrier Proteins; Cell Line, Tumor; Cell Survival; Cycloheximide; Extracellular Signal-Regulated MAP Kinases; Flavonoids; HEK293 Cells; Homer Scaffolding Proteins; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Pheochromocytoma; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Pyridines; Rats; RNA Interference; RNA, Small Interfering; Tumor Necrosis Factor-alpha | 2012 |
Up-regulation of IL-23 p19 expression in human periodontal ligament fibroblasts by IL-1β via concurrent activation of the NF-κB and MAPKs/AP-1 pathways.
Topics: Anthracenes; Blotting, Western; Cells, Cultured; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Interleukin-23 Subunit p19; JNK Mitogen-Activated Protein Kinases; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transcription Factor AP-1; Transcription Factor RelA; Up-Regulation | 2012 |
Apoptosis signal-regulating kinase 1 is mediated in TNF-α-induced CCL2 expression in human synovial fibroblasts.
Topics: Anthracenes; Antibodies; Bursa, Synovial; Chemokine CCL2; Curcumin; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression Regulation; Genes, Reporter; Humans; Imidazoles; Luciferases; MAP Kinase Kinase 4; MAP Kinase Kinase Kinase 5; Osteoarthritis; p38 Mitogen-Activated Protein Kinases; Primary Cell Culture; Pyridines; Receptors, Tumor Necrosis Factor, Type I; Signal Transduction; Thioredoxins; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2012 |
Mitogen activated protein kinases blockade improves lipopolysaccharide-induced ileal motor disturbances.
Topics: Acetylcholine; Animals; Anthracenes; Biomarkers; Butadienes; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Ileum; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Male; Mitogen-Activated Protein Kinases; Muscle Contraction; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Rabbits | 2012 |
CD99 ligation induces intercellular cell adhesion molecule-1 expression and secretion in human gingival fibroblasts.
Topics: 12E7 Antigen; Anthracenes; Antibodies, Monoclonal; Antigens, CD; Butadienes; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Culture Media, Conditioned; Endothelial Cells; Enzyme Inhibitors; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flow Cytometry; Gingiva; Humans; Imidazoles; Intercellular Adhesion Molecule-1; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Leukocytes; Leupeptins; MAP Kinase Signaling System; NF-kappa B; NF-kappa B p50 Subunit; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines | 2013 |
The p38 MAPK-MK2 axis regulates E2F1 and FOXM1 expression after epirubicin treatment.
Topics: Animals; Anthracenes; Antibiotics, Antineoplastic; Cell Cycle; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; E2F1 Transcription Factor; Enzyme Inhibitors; Epirubicin; Female; Forkhead Box Protein M1; Forkhead Transcription Factors; Gene Knockdown Techniques; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Mice, Knockout; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Serine | 2012 |
Different roles of peripheral mitogen-activated protein kinases in carrageenan-induced arthritic pain and arthritis in rats.
Topics: Animals; Anthracenes; Arthritis, Experimental; Carrageenan; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Pyridines; Random Allocation; Rats; Rats, Sprague-Dawley | 2012 |
Interleukin-1 induction of aggrecanase gene expression in human articular chondrocytes is mediated by mitogen-activated protein kinases.
Topics: Anthracenes; Butadienes; Cartilage, Articular; Cells, Cultured; Chondrocytes; Curcumin; Endopeptidases; Gene Expression Regulation; Humans; Imidazoles; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Lipoxygenases; Masoprocol; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Pyrrolidines; RNA, Messenger; Thiocarbamates; Transcription Factor AP-1 | 2012 |
Subtoxic levels hydrogen peroxide-induced expression of interleukin-6 by epidermal melanocytes.
Topics: Anthracenes; Cells, Cultured; Epidermis; Extracellular Signal-Regulated MAP Kinases; Humans; Hydrogen Peroxide; Imidazoles; Interleukin-6; Melanocytes; NF-kappa B; Nitriles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Sulfones; Up-Regulation; Vitiligo | 2012 |
Altered MAPK signaling in progressive deterioration of endothelial function in diabetic mice.
Topics: Animals; Anthracenes; Butadienes; Diabetes Mellitus, Type 2; Extracellular Signal-Regulated MAP Kinases; Imidazoles; Immunoblotting; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mitogen-Activated Protein Kinases; Nitriles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, Leptin; Resveratrol; Signal Transduction; Stilbenes; Superoxides | 2012 |
The apoptotic volume decrease is an upstream event of MAP kinase activation during Staurosporine-induced apoptosis in HeLa cells.
Topics: Anthracenes; Apoptosis; Caspase 3; Caspase 7; Cell Size; Enzyme Activation; Enzyme Inhibitors; HeLa Cells; Humans; Imidazoles; MAP Kinase Kinase 4; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Pyridines; Staurosporine | 2012 |
Effect of c-Jun N-terminal kinase (JNK)/p38 mitogen-activated protein kinase (p38 MAPK) in morphine-induced tau protein hyperphosphorylation.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anthracenes; Cells, Cultured; Cerebral Cortex; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 8; Morphine; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; tau Proteins; Time Factors | 2013 |
Actin realignment and cofilin regulation are essential for barrier integrity during shear stress.
Topics: Actins; Animals; Anthracenes; Antigens, CD; beta Catenin; Biomechanical Phenomena; Cadherins; Capillary Permeability; Cattle; Cell Nucleus; Cells, Cultured; Cofilin 1; Cytoplasm; Endothelial Cells; Enzyme Inhibitors; Imidazoles; Intercellular Junctions; Lim Kinases; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Serine; Stress, Mechanical | 2013 |
Chloroacetic acid induced neuronal cells death through oxidative stress-mediated p38-MAPK activation pathway regulated mitochondria-dependent apoptotic signals.
Topics: Acetates; Animals; Anthracenes; Apoptosis; Cell Line, Tumor; Dose-Response Relationship, Drug; Glutathione; Imidazoles; Mice; Mitochondria; Neuroblastoma; Neurons; Neurotoxicity Syndromes; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines | 2013 |
Nitric oxide activates IL-6 production and expression in human renal epithelial cells.
Topics: Anthracenes; Epithelial Cells; Escherichia coli Infections; Flavonoids; Gene Expression; Humans; Imidazoles; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Kidney; MAP Kinase Signaling System; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; RNA Stability; RNA, Messenger | 2012 |
Modulation of the ASK1-MKK3/6-p38/MAPK signalling pathway mediates sildenafil protection against chemical hypoxia caused by malonate.
Topics: Administration, Oral; Animals; Anthracenes; Apoptosis; Hypoxia, Brain; Imidazoles; Male; Malonates; MAP Kinase Signaling System; Neuroprotective Agents; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Pyridines; Rats; Rats, Wistar; Reactive Oxygen Species; Sildenafil Citrate; Sulfonamides | 2013 |
Involvement of MAPK pathways in NMDA-induced apoptosis of rat cortical neurons.
Topics: Animals; Anthracenes; Apoptosis; Caspase 3; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; N-Methylaspartate; Neurons; p38 Mitogen-Activated Protein Kinases; Primary Cell Culture; Pyridines; Rats | 2012 |
Eupatolide inhibits PDGF-induced proliferation and migration of aortic smooth muscle cells through ROS-dependent heme oxygenase-1 induction.
Topics: Acetylcysteine; Animals; Anthracenes; Aorta; Butadienes; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Imidazoles; Inula; Male; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-E2-Related Factor 2; Nitriles; Platelet-Derived Growth Factor; Pyridines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sesquiterpenes | 2013 |
CpG ODN-induced matrix metalloproteinase-13 expression is mediated via activation of the ERK and NF-κB signalling pathways in odontoblast cells.
Topics: Animals; Anthracenes; Cell Line; Chloroquine; CpG Islands; Dental Pulp; Extracellular Signal-Regulated MAP Kinases; I-kappa B Proteins; Imidazoles; MAP Kinase Signaling System; Matrix Metalloproteinase 13; Mice; Mitogen-Activated Protein Kinases; Myeloid Differentiation Factor 88; NF-kappa B; Nitriles; Odontoblasts; Oligodeoxyribonucleotides; Phosphorylation; Pyridines; Pyrrolidines; Real-Time Polymerase Chain Reaction; Signal Transduction; Sulfones; Thiocarbamates; Toll-Like Receptor 9; Tosylphenylalanyl Chloromethyl Ketone; Transcription Factor RelA | 2013 |
Effects of interleukin-1β and tumor necrosis factor-α on macrophage inflammatory protein-3α production in synovial fibroblast-like cells from human temporomandibular joints.
Topics: Adolescent; Adult; Anthracenes; Cell Culture Techniques; Chemokine CCL20; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Female; Fibroblasts; Flavonoids; Gene Expression Profiling; Humans; Imidazoles; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Joint Dislocations; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; NF-kappa B; Oligonucleotide Array Sequence Analysis; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Synovial Membrane; Temporomandibular Joint Disorders; Time Factors; Tumor Necrosis Factor-alpha; Young Adult | 2013 |
Roles of p38 MAPK and JNK in TGF-β1-induced human alveolar epithelial to mesenchymal transition.
Topics: Alveolar Epithelial Cells; Anthracenes; Aquaporin 5; Cadherins; Cell Line, Tumor; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Transforming Growth Factor beta1 | 2013 |
Human retinal pigment epithelial cells express the long pentraxin PTX3.
Topics: Anthracenes; Butadienes; C-Reactive Protein; Cell Line; Cytokines; Gene Expression; Humans; Imidazoles; Inflammation Mediators; Interferon-gamma; Interleukin-1beta; MAP Kinase Signaling System; NF-kappa B; Nitriles; Pyridines; Retinal Pigment Epithelium; RNA, Messenger; Serum Amyloid P-Component; Signal Transduction; Sulfones; Tumor Necrosis Factor-alpha | 2013 |
B-Myb switches from Cyclin/Cdk-dependent to Jnk- and p38 kinase-dependent phosphorylation and associates with SC35 bodies after UV stress.
Topics: 3T3-L1 Cells; Animals; Anthracenes; Cyclin-Dependent Kinases; Cyclins; Gene Knockout Techniques; HeLa Cells; Hep G2 Cells; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MCF-7 Cells; Mice; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-myb; Pyridines; Ribonucleoproteins; RNA Interference; RNA, Small Interfering; Serine-Arginine Splicing Factors; Ultraviolet Rays | 2013 |
TNF-α disrupts morphologic and functional barrier properties of polarized retinal pigment epithelium.
Topics: Amino Acid Chloromethyl Ketones; Animals; Anthracenes; Blood-Retinal Barrier; Blotting, Western; Cell Polarity; Cells, Cultured; Electric Impedance; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Imidazoles; In Situ Nick-End Labeling; Microscopy, Electron, Scanning; p38 Mitogen-Activated Protein Kinases; Pyridines; Recombinant Proteins; Retinal Pigment Epithelium; Swine; Tight Junction Proteins; Tight Junctions; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2013 |
P38 mitogen-activated protein kinase promotes dedifferentiation of primary articular chondrocytes in monolayer culture.
Topics: Animals; Anthracenes; Cartilage, Articular; Cattle; Cell Dedifferentiation; Cell Proliferation; Cell Survival; Chondrocytes; Chondrogenesis; Extracellular Matrix; Flavonoids; Gene Expression; Glycosaminoglycans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phenotype; Primary Cell Culture; Protein Kinase Inhibitors; Pyridines | 2013 |
Redox-sensitive up-regulation of eNOS by purple grape juice in endothelial cells: role of PI3-kinase/Akt, p38 MAPK, JNK, FoxO1 and FoxO3a.
Topics: Animals; Anthracenes; Antioxidants; Beverages; Blotting, Western; Cells, Cultured; Chromatin Immunoprecipitation; Coronary Vessels; Endothelial Cells; Forkhead Transcription Factors; Imidazoles; JNK Mitogen-Activated Protein Kinases; Metalloporphyrins; Nitric Oxide Synthase Type III; Nitrogen Oxides; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pyridines; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; RNA, Messenger; Swine; Vitis | 2013 |
Low-level shear stress induces human mesenchymal stem cell migration through the SDF-1/CXCR4 axis via MAPK signaling pathways.
Topics: Anthracenes; Benzylamines; Butadienes; Cell Movement; Cell- and Tissue-Based Therapy; Cells, Cultured; Chemokine CXCL12; Cyclams; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Heterocyclic Compounds; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mesenchymal Stem Cells; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, CXCR4; Stress, Mechanical; Wound Healing | 2013 |
Endothelin-1 stimulates the expression of L-type Ca2+ channels in neonatal rat cardiomyocytes via the extracellular signal-regulated kinase 1/2 pathway.
Topics: Animals; Animals, Newborn; Anthracenes; Blotting, Western; Cells, Cultured; Endothelin-1; Enzyme Inhibitors; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Oligopeptides; Patch-Clamp Techniques; Peptides, Cyclic; Piperidines; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2013 |
Oxidative stress and mitogen-activated protein kinase pathways involved in cadmium-induced BRL 3A cell apoptosis.
Topics: Acetylcysteine; Animals; Anthracenes; Apoptosis; Butadienes; Cadmium; Cell Line; Extracellular Signal-Regulated MAP Kinases; Glutathione Peroxidase; Imidazoles; JNK Mitogen-Activated Protein Kinases; Malondialdehyde; Mitogen-Activated Protein Kinases; Nitriles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase | 2013 |
Curcumin inhibits TGFβ1-induced CCN2 via Src, JNK, and Smad3 in gingiva.
Topics: Anthracenes; Anti-Inflammatory Agents, Non-Steroidal; Catechin; Cell Culture Techniques; Cell Movement; Cells, Cultured; Connective Tissue Growth Factor; Curcumin; Enzyme Inhibitors; Fibroblasts; Flavonoids; Gingiva; Gingival Overgrowth; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Lovastatin; MAP Kinase Kinase 4; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Signal Transduction; Smad3 Protein; src-Family Kinases; Transforming Growth Factor beta1 | 2013 |
TLR4 mediates MAPK-STAT3 axis activation in bladder epithelial cells.
Topics: Animals; Anthracenes; Cell Line, Tumor; Cystitis; Enzyme Activation; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Imidazoles; Interleukin-10; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; STAT3 Transcription Factor; Toll-Like Receptor 4; Urinary Bladder | 2013 |
Effect of nifedipine on the differentiation of human dental pulp cells cultured with mineral trioxide aggregate.
Topics: Adult; Aluminum Compounds; Anthracenes; Butadienes; Calcium; Calcium Channel Blockers; Calcium Compounds; Cell Culture Techniques; Cell Differentiation; Cell Proliferation; Cells, Cultured; Culture Media; Dental Pulp; Drug Combinations; Extracellular Matrix Proteins; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Nifedipine; Nitriles; Odontoblasts; Oxides; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Pyridines; Root Canal Filling Materials; Sialoglycoproteins; Silicates; Tooth Calcification | 2013 |
Endothelin-1 stimulates proinflammatory cytokine expression in human periodontal ligament cells via mitogen-activated protein kinase pathway.
Topics: Adult; Anthracenes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Culture Techniques; Cells, Cultured; Cytokines; Dose-Response Relationship, Drug; Endothelin B Receptor Antagonists; Endothelin Receptor Antagonists; Endothelin-1; Female; Flavonoids; Humans; Imidazoles; Interleukin-1beta; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Peptides, Cyclic; Periodontal Ligament; Periodontitis; Piperidines; Pyridines; Time Factors; Tumor Necrosis Factor-alpha | 2014 |
Branched motifs enable long-range interactions in signaling networks through retrograde propagation.
Topics: Animals; Anthracenes; Feedback, Physiological; Gene Expression Regulation; Imidazoles; Macrophages, Peritoneal; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mice; Models, Biological; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines | 2013 |
TLR4 Signaling augments monocyte chemotaxis by regulating G protein-coupled receptor kinase 2 translocation.
Topics: Animals; Anthracenes; Bone Marrow Cells; Cell Movement; Cells, Cultured; Chemokine CCL2; Chemotaxis, Leukocyte; Extracellular Signal-Regulated MAP Kinases; Flavonoids; G-Protein-Coupled Receptor Kinase 2; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Immunological; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptors, CCR2; RNA Interference; RNA, Small Interfering; Toll-Like Receptor 4 | 2013 |
Thymoquinone-induced reactive oxygen species causes apoptosis of chondrocytes via PI3K/Akt and p38kinase pathway.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetylcysteine; Animals; Anions; Anthracenes; Apoptosis; Benzoquinones; Cartilage, Articular; Cell Proliferation; Cell Survival; Chondrocytes; Enzyme Activation; Free Radical Scavengers; Imidazoles; Intracellular Space; Ion Channels; Mitochondria; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Rabbits; Reactive Oxygen Species; Signal Transduction | 2013 |
Olaquindox-induced apoptosis is suppressed through p38 MAPK and ROS-mediated JNK pathways in HepG2 cells.
Topics: Anthracenes; Apoptosis; Catalase; Cell Line, Tumor; Enzyme Inhibitors; Hep G2 Cells; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Quinoxalines; Reactive Oxygen Species; Superoxide Dismutase | 2013 |
(-)-Epigallocatechin-3-gallate inhibits CC chemokine ligand 11 production in human gingival fibroblasts.
Topics: Anthracenes; Catechin; Cells, Cultured; Chemokine CCL11; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Gingiva; Humans; Imidazoles; Interleukin-1beta; Interleukin-4; JNK Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Signal Transduction; Th2 Cells; Tumor Necrosis Factor-alpha | 2013 |
Apoptosis signal-regulating kinase 1 is involved in brain-derived neurotrophic factor (BDNF)-enhanced cell motility and matrix metalloproteinase 1 expression in human chondrosarcoma cells.
Topics: Anthracenes; Bone Neoplasms; Brain-Derived Neurotrophic Factor; Carbazoles; Cell Line, Tumor; Cell Movement; Chondrosarcoma; Humans; Imidazoles; Indole Alkaloids; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 5; Matrix Metalloproteinase 1; Neoplasm Invasiveness; Neoplasm Metastasis; p38 Mitogen-Activated Protein Kinases; Prognosis; Protein Kinases; Pyridines; Receptor, trkB; Signal Transduction; Thioredoxins; Up-Regulation | 2013 |
Carbon monoxide alleviates ethanol-induced oxidative damage and inflammatory stress through activating p38 MAPK pathway.
Topics: Alanine Transaminase; Animals; Anthracenes; Aspartate Aminotransferases; Carbon Monoxide; Ethanol; Flavonoids; Glutathione; Heme Oxygenase-1; Hepatocytes; Imidazoles; Interleukin-6; L-Lactate Dehydrogenase; Liver Diseases, Alcoholic; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Organometallic Compounds; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phytochemicals; Pyridines; Quercetin; Rats; Tumor Necrosis Factor-alpha | 2013 |
Involvement of histone H3 phosphorylation through p38 MAPK pathway activation in casticin-induced cytocidal effects against the human promyelocytic cell line HL-60.
Topics: Adenosine Triphosphate; Anthracenes; Antioxidants; Apoptosis; Caspase 3; Caspase 8; Caspase 9; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Histones; HL-60 Cells; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Leukemia, Promyelocytic, Acute; M Phase Cell Cycle Checkpoints; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Reactive Oxygen Species | 2013 |
EGF enhances ADSCs secretion via ERK and JNK pathways.
Topics: Adipose Tissue; Adult; Anthracenes; Chemokine CXCL12; Culture Media, Conditioned; Epidermal Growth Factor; Female; Flavonoids; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Lipectomy; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Primary Cell Culture; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Stem Cells; Vascular Endothelial Growth Factor A | 2014 |
Naringin inhibits ROS-activated MAPK pathway in high glucose-induced injuries in H9c2 cardiac cells.
Topics: Acetylcysteine; Animals; Anthracenes; Apoptosis; Butadienes; Cell Line; Cell Survival; Enzyme Inhibitors; Flavanones; Fruit; Glucose; Hyperglycemia; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Nitriles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plant Extracts; Pyridines; Rats; Reactive Oxygen Species | 2014 |
Interleukin-1β upregulates matrix metalloproteinase-13 gene expression via c-Jun N-terminal kinase and p38 MAPK pathways in rat hepatic stellate cells.
Topics: Animals; Anthracenes; Cell Line; Gene Expression Regulation, Enzymologic; Hepatic Stellate Cells; Imidazoles; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Matrix Metalloproteinase 13; Models, Biological; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; RNA, Messenger; Time Factors; Up-Regulation | 2013 |
Involvement of MAPK signaling pathway in the osteogenic gene expressions of Cervi Pantotrichum Cornu in MG-63 human osteoblast-like cells.
Topics: Alkaline Phosphatase; Animals; Anthracenes; Antlers; Blotting, Western; Calcium; Cell Line; Collagen; Deer; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Male; MAP Kinase Signaling System; Osteoblasts; Osteogenesis; Pyridines; Real-Time Polymerase Chain Reaction | 2014 |
Oridonin induces apoptosis in SW1990 pancreatic cancer cells via p53- and caspase-dependent induction of p38 MAPK.
Topics: Anthracenes; Apoptosis; Benzothiazoles; Caspase 3; Caspase 9; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Diterpenes, Kaurane; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; G1 Phase Cell Cycle Checkpoints; Humans; Imidazoles; Isodon; JNK Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Phosphorylation; Plant Preparations; Pyridines; RNA, Messenger; Toluene; Tumor Suppressor Protein p53 | 2014 |
Klotho suppresses cardiomyocyte apoptosis in mice with stress-induced cardiac injury via downregulation of endoplasmic reticulum stress.
Topics: Animals; Anthracenes; Apoptosis; Cells, Cultured; Endoplasmic Reticulum Stress; Gene Expression Regulation; Glucuronidase; Imidazoles; Isoproterenol; Klotho Proteins; Male; Mice; Mice, Inbred BALB C; Myocardium; Myocytes, Cardiac; Protein Kinase Inhibitors; Pyridines; Reactive Oxygen Species; Recombinant Proteins; Time Factors | 2013 |
Quercetin induces apoptosis by inhibiting MAPKs and TRPM7 channels in AGS cells.
Topics: Anthracenes; Apoptosis; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Flavonoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Quercetin; TRPM Cation Channels | 2014 |
Triggering of p38 MAPK and JNK signaling is important for oleanolic acid-induced apoptosis via the mitochondrial death pathway in hypertrophic scar fibroblasts.
Topics: Anthracenes; Apoptosis; Apoptotic Protease-Activating Factor 1; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Line; Cicatrix, Hypertrophic; Cytochromes c; Fibroblasts; Humans; Imidazoles; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mitochondria; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Pyridines; Signal Transduction | 2014 |
Resveratrol attenuates matrix metalloproteinase-9 and -2-regulated differentiation of HTB94 chondrosarcoma cells through the p38 kinase and JNK pathways.
Topics: Anthracenes; Antineoplastic Agents, Phytogenic; Bone Neoplasms; Cell Differentiation; Cell Line, Tumor; Chondrosarcoma; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Pyridines; Resveratrol; Stilbenes | 2014 |
Nitric oxide induces apoptosis in human gingival fibroblast through mitochondria-dependent pathway and JNK activation.
Topics: Anthracenes; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Butadienes; Cell Survival; Cells, Cultured; Cytochromes c; Enzyme Inhibitors; Fibroblasts; Gingiva; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Membrane Potentials; Mitochondria; Nitric Oxide; Nitriles; Nitroprusside; Pyridines; Signal Transduction | 2015 |
Biodentine induces human dental pulp stem cell differentiation through mitogen-activated protein kinase and calcium-/calmodulin-dependent protein kinase II pathways.
Topics: Adolescent; Adult; Alkaline Phosphatase; Anthracenes; Benzylamines; Butadienes; Calcium Compounds; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Culture Techniques; Cell Differentiation; Dental Pulp; Extracellular Matrix Proteins; Humans; Imidazoles; Integrin-Binding Sialoprotein; MAP Kinase Signaling System; NF-kappa B; Nitriles; Odontoblasts; Osteocalcin; Phosphoproteins; Protein Kinase Inhibitors; Pulp Capping and Pulpectomy Agents; Pyridines; Pyrrolidines; Sialoglycoproteins; Signal Transduction; Silicates; Stem Cells; Sulfonamides; Thiocarbamates; Young Adult | 2014 |
Azelnidipine inhibits cultured rat aortic smooth muscle cell death induced by cyclic mechanical stretch.
Topics: Animals; Anthracenes; Antioxidants; Aorta; Azetidinecarboxylic Acid; Blood Pressure; Cells, Cultured; Dihydropyridines; Enzyme Inhibitors; Imidazoles; JNK Mitogen-Activated Protein Kinases; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Onium Compounds; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley | 2014 |
The effects of LPS on adhesion and migration of human dental pulp stem cells in vitro.
Topics: Adolescent; Adult; Anthracenes; Benzylamines; Butadienes; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cells, Cultured; Chemokine CXCL12; Chemotactic Factors; Cyclams; Dental Pulp; Escherichia coli; Extracellular Signal-Regulated MAP Kinases; Heterocyclic Compounds; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; MAP Kinase Signaling System; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Pyrrolidines; Receptors, CXCR4; Signal Transduction; Stem Cells; Thiocarbamates; Young Adult | 2014 |
Regulation by resveratrol of prostaglandin E2-stimulated osteoprotegerin synthesis in osteoblasts.
Topics: 3T3 Cells; Animals; Anthracenes; Dinoprostone; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinase 1; Osteoblasts; Osteoprotegerin; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Resveratrol; Sirtuin 1; Stilbenes | 2014 |
Down-regulation by resveratrol of basic fibroblast growth factor-stimulated osteoprotegerin synthesis through suppression of Akt in osteoblasts.
Topics: 3T3 Cells; Animals; Anthracenes; Anti-Inflammatory Agents, Non-Steroidal; Down-Regulation; Fibroblast Growth Factor 2; Flavonoids; Heterocyclic Compounds, 4 or More Rings; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Osteoblasts; Osteoprotegerin; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Recombinant Proteins; Resveratrol; Stilbenes | 2014 |
Induction of GADD45α protects M17 neuroblastoma cells against MPP*.
Topics: 1-Methyl-4-phenylpyridinium; Analysis of Variance; Anthracenes; Blotting, Western; Caspase 3; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Chromatin Immunoprecipitation; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Imidazoles; In Situ Nick-End Labeling; Nuclear Proteins; Parkinson Disease; Pyridines; Real-Time Polymerase Chain Reaction; RNA Interference; Tetrazolium Salts; Thiazoles | 2014 |
Olmesartan inhibits cultured rat aortic smooth muscle cell death induced by cyclic mechanical stretch through the inhibition of the c-Jun N-terminal kinase and p38 signaling pathways.
Topics: Animals; Anthracenes; Cell Death; Cells, Cultured; Enzyme Inhibitors; Imidazoles; JNK Mitogen-Activated Protein Kinases; Male; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Signal Transduction; Stress, Mechanical; Tetrazoles | 2015 |
Muscarinic cholinoceptor-mediated activation of JNK negatively regulates intestinal secretion in mice.
Topics: Animals; Anthracenes; Butadienes; Extracellular Signal-Regulated MAP Kinases; Imidazoles; Intestinal Secretions; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Membrane Potentials; Mice; Muscarinic Agonists; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines | 2015 |
[The effect of edaravone on MAPKs signal pathway associated with Abeta(25-35) treatment in PC12 cells].
Topics: Amyloid beta-Peptides; Animals; Anthracenes; Antipyrine; Edaravone; Imidazoles; MAP Kinase Signaling System; PC12 Cells; Peptide Fragments; Pyridines; Rats | 2015 |
Mitogen-activated protein kinase mediates mevalonate-stimulated human mesangial cell proliferation.
Topics: Anthracenes; Apoptosis; bcl-2-Associated X Protein; Cell Cycle; Cell Line; Cell Proliferation; Collagen Type I; Collagen Type IV; Dose-Response Relationship, Drug; Extracellular Matrix; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mesangial Cells; Mevalonic Acid; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyridines; Signal Transduction; Transforming Growth Factor beta1 | 2015 |
Activation of transient receptor potential vanilloid 4 induces apoptosis in hippocampus through downregulating PI3K/Akt and upregulating p38 MAPK signaling pathways.
Topics: Animals; Anthracenes; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Down-Regulation; Enzyme Activation; Hippocampus; Imidazoles; Infarction, Middle Cerebral Artery; JNK Mitogen-Activated Protein Kinases; Leucine; Male; MAP Kinase Signaling System; Mice; Mice, Inbred ICR; Morpholines; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyridines; Pyrroles; Sulfonamides; TRPV Cation Channels | 2015 |
Regulatory Roles of Endogenous Mitogen-Activated Protein Kinases and Tyrosine Kinases in the Pacemaker Activity of Colonic Interstitial Cells of Cajal.
Topics: Animals; Anthracenes; Benzophenanthridines; Cells, Cultured; Chromones; Colon; Flavonoids; Genistein; Imidazoles; Interstitial Cells of Cajal; Intestine, Small; Membrane Potentials; Mice; Mitogen-Activated Protein Kinases; Morpholines; Naphthalenes; Protein-Tyrosine Kinases; Pyridines; Rifabutin | 2015 |
NOV inhibits proliferation while promoting apoptosis and migration in osteosarcoma cell lines through p38/MAPK and JNK/MAPK pathways.
Topics: Anthracenes; Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Nephroblastoma Overexpressed Protein; Osteosarcoma; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines | 2015 |
Early intracellular signaling events induced by in vitro metreleptin administration in cardiac myocytes and uterine smooth muscle cells.
Topics: Anthracenes; Cell Line; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Imidazoles; Janus Kinase 2; JNK Mitogen-Activated Protein Kinases; Leptin; Muscle, Smooth; Myocytes, Cardiac; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Signal Transduction; STAT3 Transcription Factor; Uterus | 2015 |
SL4, a chalcone-based compound, induces apoptosis in human cancer cells by activation of the ROS/MAPK signalling pathway.
Topics: Animals; Anthracenes; Apoptosis; bcl-X Protein; Caspase 3; Caspase 8; Caspase 9; Cell Line, Tumor; Cell Proliferation; Chalcone; Chalcones; Enzyme Activation; Female; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1; Imidazoles; Inhibitor of Apoptosis Proteins; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mice, Nude; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Neoplasms; Neovascularization, Pathologic; Pyridines; Reactive Oxygen Species; Survivin; X-Linked Inhibitor of Apoptosis Protein | 2015 |
The crosstalk between α-irradiated Beas-2B cells and its bystander U937 cells through MAPK and NF-κB signaling pathways.
Topics: Alpha Particles; Anthracenes; Apoptosis; Bronchi; Bystander Effect; Cell Proliferation; Coculture Techniques; Enzyme Inhibitors; Epithelial Cells; Feedback, Physiological; Humans; Imidazoles; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Pyridines; U937 Cells | 2016 |
DJ-1 mutation decreases astroglial release of inflammatory mediators.
Topics: Animals; Anthracenes; Astrocytes; Butadienes; Cyclooxygenase 2; Dinoprostone; Imidazoles; Inflammation Mediators; Lipopolysaccharides; Mice; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type II; Nitriles; Primary Cell Culture; Protein Deglycase DJ-1; Pyridines; Tumor Necrosis Factor-alpha | 2016 |
Uncoupling Protein 2 Increases Susceptibility to Lipopolysaccharide-Induced Acute Lung Injury in Mice.
Topics: Acute Lung Injury; Animals; Anthracenes; Apoptosis; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mitochondria; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; Uncoupling Protein 2 | 2016 |
Lentinan mitigates therarubicin-induced myelosuppression by activating bone marrow-derived macrophages in an MAPK/NF-κB-dependent manner.
Topics: Animals; Anthracenes; Bone Marrow; Doxorubicin; Female; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; I-kappa B Proteins; Imidazoles; Lentinan; Leukocytes; Macrophages; Male; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Neutrophils; NF-kappa B; Pyridines | 2016 |
Tubeimoside-1 induces oxidative stress-mediated apoptosis and G0/G1 phase arrest in human prostate carcinoma cells in vitro.
Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Anthracenes; Apoptosis; Caspase 3; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Cinnamates; Cyclin E; Cyclin-Dependent Kinase 2; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; G1 Phase; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase Kinase 5; Membrane Potential, Mitochondrial; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Pyridines; Reactive Oxygen Species; Resting Phase, Cell Cycle; Saponins; Thiourea; Triterpenes | 2016 |
MAPK-Mediated YAP Activation Controls Mechanical-Tension-Induced Pulmonary Alveolar Regeneration.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Animals; Anthracenes; Biomechanical Phenomena; cdc42 GTP-Binding Protein; Cell Cycle Proteins; Cell Proliferation; Epithelial Cells; Gene Expression Regulation; Imidazoles; Male; MAP Kinase Kinase 4; Mechanotransduction, Cellular; Mice; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Pneumonectomy; Primary Cell Culture; Pulmonary Alveoli; Pyridines; Regeneration; Respiratory Mucosa; Stem Cells; YAP-Signaling Proteins | 2016 |
Water-extracted Perilla frutescens increases endometrial receptivity though leukemia inhibitory factor-dependent expression of integrins.
Topics: Anthracenes; Butadienes; Cell Adhesion; Cells, Cultured; Endometrium; Female; Humans; Imidazoles; Integrin beta Chains; Leukemia Inhibitory Factor; Leukemia Inhibitory Factor Receptor alpha Subunit; MAP Kinase Signaling System; Nitriles; Perilla frutescens; Plant Extracts; Plant Leaves; Plant Roots; Pyridines; RNA, Small Interfering; Signal Transduction | 2016 |
Vitamin K2 Induces Mitochondria-Related Apoptosis in Human Bladder Cancer Cells via ROS and JNK/p38 MAPK Signal Pathways.
Topics: Anthracenes; Apoptosis; Cell Line, Tumor; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Membrane Potential, Mitochondrial; Mitochondria; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reactive Oxygen Species; Urinary Bladder Neoplasms; Vitamin K 2 | 2016 |
CD147 induces up-regulation of vascular endothelial growth factor in U937-derived foam cells through PI3K/AKT pathway.
Topics: Anthracenes; Atherosclerosis; Basigin; Butadienes; Chromones; Flow Cytometry; Foam Cells; Gene Expression Regulation; Gene Silencing; Humans; Imidazoles; Lipoproteins, LDL; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Signal Transduction; U937 Cells; Up-Regulation; Vascular Endothelial Growth Factor A | 2016 |
Natriuretic peptide receptor A inhibition suppresses gastric cancer development through reactive oxygen species-mediated G2/M cell cycle arrest and cell death.
Topics: Acetylcysteine; Adenine; Animals; Anthracenes; Atrial Natriuretic Factor; Autophagy; Cell Line, Tumor; Cell Proliferation; Female; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Nude; Neoplasm Staging; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; Receptors, Atrial Natriuretic Factor; RNA, Small Interfering; Stomach Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
Angiotensin-(1-7) protects cardiomyocytes against high glucose-induced injuries through inhibiting reactive oxygen species-activated leptin-p38 mitogen-activated protein kinase/extracellular signal-regulated protein kinase 1/2 pathways, but not the leptin
Topics: Acetylcysteine; Angiotensin I; Animals; Anthracenes; Apoptosis; Cell Line; Glucose; Imidazoles; Leptin; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Myocytes, Cardiac; Peptide Fragments; Pyridines; Rats; Reactive Oxygen Species | 2017 |
Ultraviolet A Enhances Cathepsin L Expression and Activity via JNK Pathway in Human Dermal Fibroblasts.
Topics: Anthracenes; Cathepsin L; Cells, Cultured; Child; Child, Preschool; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Humans; Imidazoles; MAP Kinase Signaling System; Oncogene Proteins v-fos; Proto-Oncogene Proteins c-jun; Pyridines; Skin; Ultraviolet Rays | 2016 |
Advanced oxidation protein products induce apoptosis, and upregulate sclerostin and RANKL expression, in osteocytic MLO-Y4 cells via JNK/p38 MAPK activation.
Topics: Acetylcysteine; Adaptor Proteins, Signal Transducing; Advanced Oxidation Protein Products; Animals; Anthracenes; Apoptosis; Cell Line; Glycoproteins; Imidazoles; Intercellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Mice; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Pyridines; RANK Ligand; Reactive Oxygen Species; Signal Transduction; Up-Regulation | 2017 |
Evidence that NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anthracenes; Apoptosis Regulatory Proteins; Brain; Brain Ischemia; Butadienes; Extracellular Signal-Regulated MAP Kinases; Imidazoles; Inflammasomes; Mice; Neurons; NF-kappa B; Nitriles; NLR Family, Pyrin Domain-Containing 3 Protein; Pyridines; Signal Transduction; Stroke; Sulfones | 2018 |
GADD45a Regulates Olaquindox-Induced DNA Damage and S-Phase Arrest in Human Hepatoma G2 Cells via JNK/p38 Pathways.
Topics: Animal Feed; Anthracenes; Anti-Bacterial Agents; Apoptosis; Cell Cycle Proteins; Cell Proliferation; Cell Survival; Comet Assay; DNA Fragmentation; Food Additives; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Imidazoles; MAP Kinase Kinase 4; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Quinoxalines; Reactive Oxygen Species; S Phase; Signal Transduction | 2017 |
Thymol inhibits bladder cancer cell proliferation via inducing cell cycle arrest and apoptosis.
Topics: Acetylcysteine; Anthracenes; Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Caspase 9; Cell Line, Transformed; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Epithelial Cells; Free Radical Scavengers; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyridines; Reactive Oxygen Species; Thymol; Urothelium | 2017 |
Interleukin-1β affects the phospholipid biosynthesis of fibroblast-like synoviocytes from human osteoarthritic knee joints.
Topics: Aged; Aged, 80 and over; Anthracenes; Cytokines; Enzyme Inhibitors; Female; Fibroblasts; Glycoproteins; Humans; Hyaluronic Acid; Imidazoles; Interleukin-1beta; Interleukin-6; Knee Joint; Male; MAP Kinase Signaling System; Middle Aged; NF-kappa B; Osteoarthritis, Knee; p38 Mitogen-Activated Protein Kinases; Phospholipids; Pyridines; Signal Transduction; Spectrometry, Mass, Electrospray Ionization; Synovial Fluid; Synoviocytes; Tandem Mass Spectrometry; Tumor Necrosis Factor-alpha | 2017 |
Heat shock protein 27 (HSPB1) suppresses the PDGF-BB-induced migration of osteoblasts.
Topics: Animals; Anthracenes; Becaplermin; Cell Line; Cell Movement; Flavonoids; HSP27 Heat-Shock Proteins; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Osteoblasts; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-sis; Pyridines; Sirolimus | 2017 |
Resveratrol Inhibits the Epidermal Growth Factor-Induced Migration of Osteoblasts: the Suppression of SAPK/JNK and Akt.
Topics: Animals; Anthracenes; Cell Movement; Cells, Cultured; Epidermal Growth Factor; Flavonoids; Heterocyclic Compounds, 4 or More Rings; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Resveratrol; rho-Associated Kinases; Sirtuin 1; Stilbenes | 2017 |
Pratol, an O-Methylated Flavone, Induces Melanogenesis in B16F10 Melanoma Cells via p-p38 and p-JNK Upregulation.
Topics: Animals; Anthracenes; Cell Line, Tumor; Flavones; Imidazoles; Intramolecular Oxidoreductases; Mice; Molecular Structure; Oxidoreductases; Phosphorylation; Proto-Oncogene Proteins c-jun; Pyridines; Trifolium | 2017 |
The fungal neurotoxin penitrem A induces the production of reactive oxygen species in human neutrophils at submicromolar concentrations.
Topics: Anthracenes; Antioxidants; Calcineurin; Cell Line; Cyclosporine; Granulocytes; Humans; Imidazoles; Inhibitory Concentration 50; JNK Mitogen-Activated Protein Kinases; Mycotoxins; Neurotoxins; Neutrophils; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; Tacrolimus; Vitamin E | 2017 |
Renoprotective effect of erythropoietin via modulation of the STAT6/MAPK/NF-κB pathway in ischemia/reperfusion injury after renal transplantation.
Topics: Acetylcysteine; Animals; Anthracenes; Apoptosis; Erythropoietin; Gene Expression Regulation; Humans; Imidazoles; Interferon-gamma; Kidney; Kidney Transplantation; Lentivirus; MAP Kinase Kinase 4; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pyridines; Pyrimidines; Rats; Reperfusion Injury; RNA, Small Interfering; Signal Transduction; STAT6 Transcription Factor | 2018 |
Protocatechuic acid inhibits Toll-like receptor-4-dependent activation of NF-κB by suppressing activation of the Akt, mTOR, JNK and p38-MAPK.
Topics: Acetylcysteine; Anthracenes; Anti-Inflammatory Agents; Cell Line, Transformed; Cytokines; Humans; Hydroxybenzoates; Imidazoles; Keratinocytes; Lipopolysaccharides; MAP Kinase Kinase 4; Nitriles; Oncogene Protein v-akt; p38 Mitogen-Activated Protein Kinases; Pyridines; Signal Transduction; Sulfones; TOR Serine-Threonine Kinases | 2018 |
Chronic intermittent hypobaric hypoxia provides vascular protection in the aorta of the 2-kidney, 1-clip rat model of hypertension.
Topics: Acetylcholine; Animals; Anthracenes; Aorta; Basic Helix-Loop-Helix Transcription Factors; Blood Pressure; Body Weight; Bone Morphogenetic Protein 4; Carrier Proteins; Chronic Disease; Disease Models, Animal; Endothelium, Vascular; Flavonoids; Hypertension; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; In Vitro Techniques; Kidney; Male; Nitric Oxide Synthase Type III; Nitroprusside; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats, Sprague-Dawley; Surgical Instruments; Systole; Vasodilation | 2018 |
Piperine functions as a tumor suppressor for human ovarian tumor growth via activation of JNK/p38 MAPK-mediated intrinsic apoptotic pathway.
Topics: Alkaloids; Anthracenes; Apoptosis; Benzodioxoles; Caspase 3; Caspase 9; Caspase Inhibitors; Cell Proliferation; Cell Survival; Female; Humans; Imidazoles; MAP Kinase Kinase 4; Oligopeptides; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Piperidines; Polyunsaturated Alkamides; Pyridines; Tumor Suppressor Proteins | 2018 |
Curcumin suppresses JNK pathway to attenuate BPA-induced insulin resistance in LO2 cells.
Topics: Anthracenes; Benzhydryl Compounds; Cell Line; Curcumin; Enzyme Activation; Humans; Imidazoles; Inflammation; Insulin Resistance; MAP Kinase Signaling System; NF-kappa B; Oxidative Stress; Phenols; Pyridines; Pyrrolidines; Thiocarbamates | 2018 |
Betulinic acid alleviates myocardial hypoxia/reoxygenation injury via inducing Nrf2/HO-1 and inhibiting p38 and JNK pathways.
Topics: Animals; Anthracenes; Apoptosis; Betulinic Acid; Cell Hypoxia; Cell Survival; Heme Oxygenase-1; Imidazoles; JNK Mitogen-Activated Protein Kinases; Myocardial Reperfusion Injury; Myocytes, Cardiac; NF-E2-Related Factor 2; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pentacyclic Triterpenes; Protective Agents; Pyridines; Rats; RNA, Small Interfering; Signal Transduction; Triterpenes | 2018 |
Phorbol esters induce PLVAP expression via VEGF and additional secreted molecules in MEK1-dependent and p38, JNK and PI3K/Akt-independent manner.
Topics: Anthracenes; Autocrine Communication; Axitinib; Butadienes; Flavonoids; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Indazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 4; Membrane Proteins; Nitriles; Phosphatidylinositol 3-Kinases; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; RNA, Small Interfering; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2019 |
Activation of CXCL5-CXCR2 axis promotes proliferation and accelerates G1 to S phase transition of papillary thyroid carcinoma cells and activates JNK and p38 pathways.
Topics: Animals; Anthracenes; Cell Line, Tumor; Cell Proliferation; Chemokine CXCL5; G1 Phase Cell Cycle Checkpoints; Humans; Imidazoles; MAP Kinase Signaling System; Mice; Mice, Nude; Phenylurea Compounds; Phosphorylation; Pyridines; Receptors, Interleukin-8B; Recombinant Proteins; Thyroid Cancer, Papillary; Thyroid Neoplasms; Xenograft Model Antitumor Assays | 2019 |
A novel role of angiotensin II in epidermal cell lineage determination: Angiotensin II promotes the differentiation of mesenchymal stem cells into keratinocytes through the p38 MAPK, JNK and JAK2 signalling pathways.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Anthracenes; Bone Marrow Cells; Cell Differentiation; Cell Lineage; Cell Movement; Imidazoles; Janus Kinase 2; Janus Kinases; Keratinocytes; Losartan; Male; MAP Kinase Signaling System; Mesenchymal Stem Cells; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tyrphostins | 2019 |
Up-regulation of DcR3 in microbial toxins-stimulated HUVECs involves NF-κB signalling.
Topics: Anthracenes; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Jurkat Cells; Lipopolysaccharides; NF-kappa B; Proline; Protein Kinase Inhibitors; Pyridines; Receptors, Tumor Necrosis Factor, Member 6b; Signal Transduction; Teichoic Acids; Thiocarbamates; Up-Regulation; Zymosan | 2018 |
Integrative identification of unexpected kinase-inhibitor interactions in the MAPK-mediated proliferation and differentiation of Mc3T3-E1 osteoblasts.
Topics: Aniline Compounds; Animals; Anthracenes; Cell Differentiation; Cell Line; Cell Proliferation; Dasatinib; Imidazoles; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase Kinases; Nitriles; Osteoblasts; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Quinolines | 2019 |
Requisite roles of LOX-1, JNK, and arginase in diabetes-induced endothelial vasodilator dysfunction of porcine coronary arterioles.
Topics: Animals; Anthracenes; Arginase; Arterioles; Coronary Vessels; Cyclic N-Oxides; Diabetes Mellitus, Experimental; Dioxanes; Imidazoles; In Vitro Techniques; JNK Mitogen-Activated Protein Kinases; Male; Nitric Oxide; Pyridines; Scavenger Receptors, Class E; Serotonin; Spin Labels; Swine; Thiazoles; Vasodilation | 2019 |
STRIP2 silencing inhibits vascular smooth muscle cell proliferation and migration via P38-AKT-MMP-2 signaling pathway.
Topics: Acetates; Alkaloids; Animals; Anthracenes; Axin Protein; Benzopyrans; Butadienes; Cell Line; Cell Movement; Cell Proliferation; Cytoskeletal Proteins; Gene Expression Regulation; Gene Knockdown Techniques; Gene Silencing; Imidazoles; Matrix Metalloproteinase 2; Mice; Mitomycin; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; Pyridines | 2019 |
MAPK Pathway Inhibitors Attenuated Hydrogen Peroxide Induced Damage in Neural Cells.
Topics: Animals; Anthracenes; Butadienes; Cell Survival; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Imidazoles; Mice; Mitogen-Activated Protein Kinase Kinases; Neurodegenerative Diseases; Neurons; Nitriles; Oxidative Stress; PC12 Cells; Primary Cell Culture; Pyridines; Rats; Reactive Oxygen Species | 2019 |
8-Methoxycoumarin enhances melanogenesis
Topics: Animals; Anthracenes; Coumarins; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Imidazoles; MAP Kinase Signaling System; Melanins; Melanoma, Experimental; Mice; Proto-Oncogene Proteins c-akt; Pyridines; Ruta; Signal Transduction | 2019 |
Naringenin Exerts Cardiovascular Protective Effect in a Palmitate-Induced Human Umbilical Vein Endothelial Cell Injury Model via Autophagy Flux Improvement.
Topics: Acetylcysteine; Anthracenes; Apoptosis; Autophagy; Cardiotonic Agents; Chloroquine; Endothelium, Vascular; Flavanones; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; MAP Kinase Signaling System; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Palmitates; Pyridines; Reactive Oxygen Species | 2019 |
A platform for studying the transfer of Chlamydia pneumoniae infection between respiratory epithelium and phagocytes.
Topics: Anthracenes; Cell Line; Chlamydophila Infections; Chlamydophila pneumoniae; Coculture Techniques; Epithelial Cells; Epithelium; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Macrophages; Monocytes; p38 Mitogen-Activated Protein Kinases; Polymerase Chain Reaction; Pyrazoles; Pyridazines; Pyridines; THP-1 Cells | 2020 |
The mechanism of Mitogen-Activated Protein Kinases to mediate apoptosis and immunotoxicity induced by Benzo[a]pyrene on hemocytes of scallop Chlamys farreri in vitro.
Topics: Animals; Anthracenes; Apoptosis; Benzo(a)pyrene; Enzyme Inhibitors; Flavonoids; Hemocytes; Imidazoles; Mitogen-Activated Protein Kinases; Pectinidae; Phosphorylation; Pyridines | 2020 |
Novel role of CXCL14 in modulating STAR expression in luteinized granulosa cells: implication for progesterone synthesis in PCOS patients.
Topics: Adult; Anthracenes; Cells, Cultured; Chemokines, CXC; Cholesterol Side-Chain Cleavage Enzyme; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Female; Flavonoids; Gene Expression Regulation; Granulosa Cells; Humans; Imidazoles; Phosphoproteins; Polycystic Ovary Syndrome; Progesterone; Progesterone Reductase; Pyridines | 2021 |
Two Small Molecule Inhibitors Promote Reprogramming of Guangxi Bama Mini-Pig Mesenchymal Stem Cells Into Naive-Like State Induced Pluripotent Stem Cells.
Topics: Animals; Anthracenes; Cell Differentiation; Cellular Reprogramming; Enzyme Inhibitors; Imidazoles; Induced Pluripotent Stem Cells; Mesenchymal Stem Cells; Pyridines; Swine; Swine, Miniature | 2021 |
Exosomes From Packed Red Cells Induce Human Mast Cell Activation and the Production of Multiple Inflammatory Mediators.
Topics: Adolescent; Adult; Anthracenes; Blood Donors; Blood Transfusion; Cell Line; Cell Survival; Erythrocytes; Exosomes; Flavonoids; Humans; Imidazoles; Immunity, Innate; Inflammation Mediators; Male; MAP Kinase Signaling System; Mast Cells; Middle Aged; Mitogen-Activated Protein Kinases; Pyridines; Toll-Like Receptor 3; Young Adult | 2021 |
MAPK inhibitors protect against early‑stage osteoarthritis by activating autophagy.
Topics: Animals; Anthracenes; Autophagy; Butadienes; Disease Models, Animal; Imidazoles; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Osteoarthritis; Protein Kinase Inhibitors; Pyridines; Rabbits; Severity of Illness Index | 2021 |
miR-132-3p Modulates DUSP9-Dependent p38/JNK Signaling Pathways to Enhance Inflammation in the Amnion Leading to Labor.
Topics: Amnion; Animals; Anthracenes; Cyclooxygenase 2; Dual-Specificity Phosphatases; Epithelial Cells; Female; Imidazoles; Inflammation; Labor, Obstetric; Male; MAP Kinase Signaling System; Mice; MicroRNAs; Pregnancy; Pyridines | 2022 |