Compounds > sb 203580
Page last updated: 2024-09-05

sb 203580 and pd 184352

sb 203580 has been researched along with pd 184352 in 9 studies

Compound Research Comparison

Studies
(sb 203580)		Trials
(sb 203580)		Recent Studies (post-2010)
(sb 203580)		Studies
(pd 184352)		Trials
(pd 184352)		Recent Studies (post-2010) (pd 184352)
3,48941,137185374

Protein Interaction Comparison

ProteinTaxonomysb 203580 (IC50)pd 184352 (IC50)
RAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)0.012
Dual specificity mitogen-activated protein kinase kinase 2Homo sapiens (human)0.0263
Casein kinase II subunit alphaHomo sapiens (human)0.017
Dual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)0.0218

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (55.56)29.6817
2010's2 (22.22)24.3611
2020's2 (22.22)2.80

Authors

AuthorsStudies
Caivano, M; Cohen, P; Davies, SP; Reddy, H1
Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N1
Chen, YD; Jiao, Y; Li, HF; Lu, T; Wang, X; Zhang, LY; Zhu, T1
Ciceri, P; Davis, MI; Herrgard, S; Hocker, M; Hunt, JP; Pallares, G; Treiber, DK; Wodicka, LM; Zarrinkar, PP1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Bharate, SB; Raghuvanshi, R1
Caballero, E; García-Cárceles, J; Gil, C; Martínez, A1
Campbell, DG; Cheung, PC; Cohen, P; Nebreda, AR1
Centeno, F; Cuenda, A; Feijoo, C; Garner, C; Goedert, M; Hasegawa, M; Kuhlendahl, S; Leal-Ortiz, S; Reuver, S; Sabio, G; Thomas, GM1

Reviews

1 review(s) available for sb 203580 and pd 184352

ArticleYear
Kinase Inhibitors as Underexplored Antiviral Agents.
    Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2

    Topics: Animals; Antiviral Agents; Drug Repositioning; Humans; Protein Kinase Inhibitors; Virus Diseases; Viruses

2022

Other Studies

8 other study(ies) available for sb 203580 and pd 184352

ArticleYear
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
    The Biochemical journal, 2000, Oct-01, Volume: 351, Issue:Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides

2000
The selectivity of protein kinase inhibitors: a further update.
    The Biochemical journal, 2007, Dec-15, Volume: 408, Issue:3

    Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera

2007
Pharmacophore identification of Raf-1 kinase inhibitors.
    Bioorganic & medicinal chemistry letters, 2008, Apr-01, Volume: 18, Issue:7

    Topics: Binding Sites; Biological Transport; Enzyme Inhibitors; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Models, Biological; Models, Chemical; Proto-Oncogene Proteins c-raf; Structure-Activity Relationship

2008
Comprehensive analysis of kinase inhibitor selectivity.
    Nature biotechnology, 2011, Oct-30, Volume: 29, Issue:11

    Topics: Catalysis; Drug Design; Enzyme Stability; High-Throughput Screening Assays; Humans; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Proteomics; Signal Transduction; Substrate Specificity

2011
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections.
    Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2

    Topics: Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Drug Approval; Drug Repositioning; High-Throughput Screening Assays; Humans; Protein Kinase Inhibitors; SARS-CoV-2; United States; United States Food and Drug Administration; Virus Diseases

2022
Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha.
    The EMBO journal, 2003, Nov-03, Volume: 22, Issue:21

    Topics: Adaptor Proteins, Signal Transducing; Animals; Benzamides; Binding Sites; Carrier Proteins; Cell Line; Enzyme Activation; Enzyme Inhibitors; Feedback; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase Kinases; Mice; Mitogen-Activated Protein Kinases; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Subunits; Pyridines; Recombinant Proteins; Two-Hybrid System Techniques

2003
Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2.
    The Biochemical journal, 2004, May-15, Volume: 380, Issue:Pt 1

    Topics: Amino Acid Sequence; Animals; Benzamides; Cell Line; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; MAP Kinase Signaling System; Mice; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mitogens; Molecular Sequence Data; Nerve Tissue Proteins; Neurons; Osmotic Pressure; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Interaction Mapping; Protein Processing, Post-Translational; Protein Structure, Tertiary; Pyridines; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; SAP90-PSD95 Associated Proteins; Stress, Physiological; Ultraviolet Rays

2004