Compounds > sb 203580
Page last updated: 2024-09-05

sb 203580 and paroxetine

sb 203580 has been researched along with paroxetine in 3 studies

Compound Research Comparison

Studies
(sb 203580)		Trials
(sb 203580)		Recent Studies (post-2010)
(sb 203580)		Studies
(paroxetine)		Trials
(paroxetine)		Recent Studies (post-2010) (paroxetine)
3,48941,1374,2571,0311,031

Protein Interaction Comparison

ProteinTaxonomysb 203580 (IC50)paroxetine (IC50)
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)3.9
MyeloperoxidaseHomo sapiens (human)0.02
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)0.086
Muscarinic acetylcholine receptor M2Homo sapiens (human)0.532
Muscarinic acetylcholine receptor M4Homo sapiens (human)0.244
Muscarinic acetylcholine receptor M5Homo sapiens (human)0.123
Quinolone resistance protein NorAStaphylococcus aureus7
Cytochrome P450 2D6Homo sapiens (human)0.5003
Muscarinic acetylcholine receptor M1Homo sapiens (human)0.145
Muscarinic acetylcholine receptor M3Homo sapiens (human)0.179
Beta-adrenergic receptor kinase 1Bos taurus (cattle)1.08
Sodium-dependent noradrenaline transporter Homo sapiens (human)0.093
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)0.623
Beta-adrenergic receptor kinase 1Homo sapiens (human)1.24
Substance-P receptorHomo sapiens (human)0.9
Sodium-dependent serotonin transporterHomo sapiens (human)0.0007
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)0.0003
P2X purinoceptor 4Rattus norvegicus (Norway rat)2.45
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)3.9
Sodium-dependent dopamine transporter Homo sapiens (human)0.672
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)3.9
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)3.9
P2X purinoceptor 4Homo sapiens (human)2.8067
Sigma non-opioid intracellular receptor 1Homo sapiens (human)5.366
TransporterRattus norvegicus (Norway rat)0.535

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H1
Chou, CT; He, S; Jan, CR1
Campos-Torres, A; Haase, J; Malynn, S; Moynagh, P1

Other Studies

3 other study(ies) available for sb 203580 and paroxetine

ArticleYear
Identifying off-target effects and hidden phenotypes of drugs in human cells.
    Nature chemical biology, 2006, Volume: 2, Issue:6

    Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

2006
Paroxetine-induced apoptosis in human osteosarcoma cells: activation of p38 MAP kinase and caspase-3 pathways without involvement of [Ca2+]i elevation.
    Toxicology and applied pharmacology, 2007, Feb-01, Volume: 218, Issue:3

    Topics: Apoptosis; Calcium Signaling; Caspase 3; Cell Line; Cell Survival; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; Endoplasmic Reticulum; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Imidazoles; JNK Mitogen-Activated Protein Kinases; Osteoblasts; Osteosarcoma; p38 Mitogen-Activated Protein Kinases; Paroxetine; Phosphorylation; Pyridines; Selective Serotonin Reuptake Inhibitors

2007
The pro-inflammatory cytokine TNF-α regulates the activity and expression of the serotonin transporter (SERT) in astrocytes.
    Neurochemical research, 2013, Volume: 38, Issue:4

    Topics: Astrocytes; Cell Line, Tumor; Citalopram; Fluoxetine; Glioma; Humans; Imidazoles; p38 Mitogen-Activated Protein Kinases; Paroxetine; Pyridines; Serotonin; Serotonin Plasma Membrane Transport Proteins; Tumor Necrosis Factor-alpha

2013