Compounds > sb 203580

Page last updated: 2024-09-05

sb 203580 and paclitaxel

sb 203580 has been researched along with paclitaxel in 18 studies

Compound Research Comparison

Studies (sb 203580)	Trials (sb 203580)	Recent Studies (post-2010) (sb 203580)	Studies (paclitaxel)	Trials (paclitaxel)	Recent Studies (post-2010) (paclitaxel)
3,489	4	1,137	31,874	5,729	15,395

Protein Interaction Comparison

Protein	Taxonomy	sb 203580 (IC50)	paclitaxel (IC50)
Integrin beta-3	Homo sapiens (human)		0.034
Integrin alpha-V	Homo sapiens (human)		0.034
ATP-dependent translocase ABCB1	Homo sapiens (human)		2.598
Botulinum neurotoxin type A	Clostridium botulinum		5.2
UDP-glucuronosyltransferase 2B7	Homo sapiens (human)		4.9
UDP-glucuronosyltransferase 1-6	Homo sapiens (human)		4.9
Substance-K receptor	Homo sapiens (human)		6.125
UDP-glucuronosyltransferase 1A1	Homo sapiens (human)		4.9
UDP-glucuronosyltransferase 1A4	Homo sapiens (human)		4.9
UDP-glucuronosyltransferase 2B10	Homo sapiens (human)		4.9
Delta-type opioid receptor	Homo sapiens (human)		4.202
Tyrosine-protein kinase Mer	Homo sapiens (human)		4.9
Tubulin beta-3 chain	Homo sapiens (human)		0.0082
Beta-tubulin	Leishmania donovani		1
Nucleotide-binding oligomerization domain-containing protein 2	Homo sapiens (human)		7.9433
Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)		0.26
Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)		0.28

Research

Studies (18)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	15 (83.33)	29.6817
2010's	3 (16.67)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H	1
Henne, WA; Kularatne, SA; Low, PS; Santhapuram, HK; Vaitilingam, B; Venkatesh, C; Wang, K	1
Bacus, SS; Gudkov, AV; Keyomarsi, K; Komarov, AP; Lowe, M; Lyass, L; Seger, R; Yarden, Y; Yung, Y	1
Arvidsson, Y; Funa, K; Hamazaki, TS; Ichijo, H	1
Horwitz, SB; Yang, CP	1
Boldt, S; Kolch, W; Weidle, UH	1
Bertino, JR; Li, W	1
Birukova, A; Garcia, JG; Petrache, I; Ramirez, SI; Verin, AD	1
Gil, JE; Kim, JH; Moon, EY; Oh, SY; Song, JH; Yeom, YI	1
Babó, I; Harisi, R; Jeney, A; Kenessey, I; Oláh, J; Pogány, G; Timár, F	1
Adyshev, D; Bogatcheva, NV; Mambetsariev, B; Moldobaeva, N; Verin, AD	1
Li, Z; Lu, M; Xiao, L	1
Deng, S; Hu, J; Lu, M; Xiao, L; Xu, Y	1
Jou, I; Kim, HY; Park, JY; Park, SM	1
Hendricks, M; Jesuthasan, S	1
Babo, I; Harisi, R; Jeney, A; Kenessey, I; Olah, JN; Paku, S; Pogany, G; Timar, F	1
Domoto, R; Kawabata, A; Nakashima, K; Nishibori, M; Sekiguchi, F; Tsubota, M; Wake, H; Yamanishi, H; Yamasoba, D	1
Hu, Z; Lai, W; Li, R; Ma, Y; Shi, F; Yue, C; Zhao, M	1

Reviews

1 review(s) available for sb 203580 and paclitaxel

Article	Year
[Study of drugs against neoplastic metastasis]. Magyar onkologia, 2006, Volume: 50, Issue:2 Topics: Animals; Antineoplastic Agents; Cell Movement; Chromones; Deoxyuridine; Doxorubicin; Enzyme Inhibitors; Fatty Alcohols; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Morpholines; Neoplasm Metastasis; Paclitaxel; Pyridines; Ribavirin; Signal Transduction; Sirolimus	2006

Other Studies

17 other study(ies) available for sb 203580 and paclitaxel

Article	Year
Identifying off-target effects and hidden phenotypes of drugs in human cells. Nature chemical biology, 2006, Volume: 2, Issue:6 Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship	2006
Synthesis and biological analysis of prostate-specific membrane antigen-targeted anticancer prodrugs. Journal of medicinal chemistry, 2010, Nov-11, Volume: 53, Issue:21 Topics: Antigens, Surface; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Glutamate Carboxypeptidase II; Glutarates; Humans; Ligands; Male; Molecular Targeted Therapy; Prodrugs; Prostatic Neoplasms; Structure-Activity Relationship; Urea	2010
Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53. Oncogene, 2001, Jan-11, Volume: 20, Issue:2 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Carcinoma; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Female; Flavonoids; G2 Phase; Humans; Imidazoles; MAP Kinase Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Mitosis; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Protein Serine-Threonine Kinases; Pyridines; Rats; Receptor, ErbB-2; Retinoblastoma Protein; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2001
ASK1 resistant neuroblastoma is deficient in activation of p38 kinase. Cell death and differentiation, 2001, Volume: 8, Issue:10 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Division; DNA; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Kinetics; MAP Kinase Kinase Kinase 5; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Mutation; Neuroblastoma; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Phosphorylation; Pyridines; Tumor Cells, Cultured	2001
Distinct mechanisms of taxol-induced serine phosphorylation of the 66-kDa Shc isoform in A549 and RAW 264.7 cells. Biochimica et biophysica acta, 2002, Jun-12, Volume: 1590, Issue:1-3 Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Antineoplastic Agents, Phytogenic; Butadienes; Cell Line; Enzyme Inhibitors; Gene Expression; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Phosphorylation; Proteins; Pyridines; Serine; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Threonine; Tumor Necrosis Factor-alpha	2002
The role of MAPK pathways in the action of chemotherapeutic drugs. Carcinogenesis, 2002, Volume: 23, Issue:11 Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma, Squamous Cell; Cell Cycle; Ceramides; Enzyme Activation; Enzyme Inhibitors; Etoposide; Female; Flavonoids; HeLa Cells; Humans; Imidazoles; MAP Kinase Signaling System; Microtubules; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Paclitaxel; Pyridines; Skin Neoplasms; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Tumor Stem Cell Assay	2002
Fas-mediated signaling enhances sensitivity of human soft tissue sarcoma cells to anticancer drugs by activation of p38 kinase. Molecular cancer therapeutics, 2002, Volume: 1, Issue:14 Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Blotting, Western; Caspase 9; Caspases; Cell Cycle; Cell Death; Cell Separation; Chalcone; Chalcones; Cytochrome c Group; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Activation; fas Receptor; Flow Cytometry; Humans; Imidazoles; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Pyridines; Sarcoma; Signal Transduction; Soft Tissue Neoplasms; Time Factors; Tumor Cells, Cultured	2002
The role of the microtubules in tumor necrosis factor-alpha-induced endothelial cell permeability. American journal of respiratory cell and molecular biology, 2003, Volume: 28, Issue:5 Topics: Actins; Adherens Junctions; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cells, Cultured; Cytoskeleton; Electric Impedance; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Immunohistochemistry; Microtubules; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Pulmonary Artery; Pyridines; Tumor Necrosis Factor-alpha	2003
ERK activation by thymosin-beta-4 (TB4) overexpression induces paclitaxel-resistance. Experimental cell research, 2006, May-15, Volume: 312, Issue:9 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Imidazoles; Mice; NIH 3T3 Cells; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Phosphorylation; Pyridines; ras Proteins; RNA, Small Interfering; Thymosin; Transfection	2006
Involvement of microtubules, p38, and Rho kinases pathway in 2-methoxyestradiol-induced lung vascular barrier dysfunction. American journal of physiology. Lung cellular and molecular physiology, 2007, Volume: 292, Issue:2 Topics: 2-Methoxyestradiol; Actomyosin; Amides; Blood-Air Barrier; Cell Membrane Permeability; Endothelial Cells; Estradiol; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Microelectrodes; Microtubules; Models, Biological; Myosin-Light-Chain Kinase; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Phosphorylation; Protein Serine-Threonine Kinases; Pulmonary Artery; Pyridines; rho-Associated Kinases; Tubulin	2007
The relationship between p38MAPK and apoptosis during paclitaxel resistance of ovarian cancer cells. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2007, Volume: 27, Issue:6 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Humans; Imidazoles; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Pyridines; RNA, Messenger; Transfection; Tumor Suppressor Protein p53	2007
Targeting of p38 mitogen-activated protein kinases to early growth response gene 1 (EGR-1) in the human paclitaxel-resistance ovarian carcinoma cells. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2008, Volume: 28, Issue:4 Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Drug Resistance, Neoplasm; Early Growth Response Protein 1; Female; Humans; Imidazoles; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Pyridines; Signal Transduction	2008
GM1 induces p38 and microtubule dependent ramification of rat primary microglia in vitro. Brain research, 2008, Dec-09, Volume: 1244 Topics: Animals; Blotting, Western; Cell Differentiation; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; G(M1) Ganglioside; Gangliosides; Imidazoles; Interferon-gamma; Lipopolysaccharides; Microglia; Microscopy, Confocal; Microtubules; Nerve Growth Factor; Neurotrophin 3; Nocodazole; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Pyridines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Tubulin Modulators	2008
PHR regulates growth cone pausing at intermediate targets through microtubule disassembly. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, May-20, Volume: 29, Issue:20 Topics: Animals; Anthracenes; Apoptosis Regulatory Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Death-Associated Protein Kinases; Dose-Response Relationship, Drug; Electroporation; Enzyme Inhibitors; Gene Expression Regulation; Green Fluorescent Proteins; Growth Cones; Imidazoles; MAP Kinase Kinase 4; Membrane Proteins; Mice; Mice, Transgenic; Microtubules; Neurons; Nocodazole; Paclitaxel; Phosphorylation; Prosencephalon; Pyridines; Signal Transduction; Spinal Cord; Tubulin Modulators; Zebrafish; Zebrafish Proteins	2009
Differential inhibition of single and cluster type tumor cell migration. Anticancer research, 2009, Volume: 29, Issue:8 Topics: Adolescent; Bone Neoplasms; Cell Culture Techniques; Cell Movement; Cell Proliferation; Chromones; Deoxyuridine; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibrosarcoma; Flavonoids; Humans; Imidazoles; Male; Morpholines; Okadaic Acid; Osteosarcoma; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; Tumor Cells, Cultured	2009
Paclitaxel-induced HMGB1 release from macrophages and its implication for peripheral neuropathy in mice: Evidence for a neuroimmune crosstalk. Neuropharmacology, 2018, Volume: 141 Topics: Acetylcysteine; Animals; Antibodies; Cells, Cultured; Clodronic Acid; Coculture Techniques; Ganglia, Spinal; HMGB1 Protein; Hyperalgesia; Imidazoles; Macrophages; Male; Membrane Proteins; Mice; Minocycline; Neurons; p300-CBP Transcription Factors; Paclitaxel; Peripheral Nervous System Diseases; Phosphoproteins; Phosphorylation; Proline; Pyridines; Pyruvates; Reactive Oxygen Species; Receptor for Advanced Glycation End Products; Receptors, CXCR4; Recombinant Proteins; Sciatic Nerve; Thiocarbamates; Thrombomodulin; Up-Regulation	2018
Plastin 3 down-regulation augments the sensitivity of MDA-MB-231 cells to paclitaxel via the p38 MAPK signalling pathway. Artificial cells, nanomedicine, and biotechnology, 2019, Volume: 47, Issue:1 Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Down-Regulation; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Imidazoles; MAP Kinase Signaling System; Membrane Glycoproteins; Microfilament Proteins; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Pyridines	2019