Page last updated: 2024-09-05

sb 203580 and ng-nitroarginine methyl ester

sb 203580 has been researched along with ng-nitroarginine methyl ester in 18 studies

Compound Research Comparison

Studies
(sb 203580)
Trials
(sb 203580)
Recent Studies (post-2010)
(sb 203580)
Studies
(ng-nitroarginine methyl ester)
Trials
(ng-nitroarginine methyl ester)
Recent Studies (post-2010) (ng-nitroarginine methyl ester)
3,48941,13712,6401172,342

Protein Interaction Comparison

ProteinTaxonomysb 203580 (IC50)ng-nitroarginine methyl ester (IC50)
Neutrophil elastaseHomo sapiens (human)2.7
Nitric oxide synthase, endothelialHomo sapiens (human)2.1
Nitric oxide synthase, brainHomo sapiens (human)1.1167
Nitric oxide synthase, inducibleMus musculus (house mouse)2.6
Nitric oxide synthase, inducibleHomo sapiens (human)8
Collagenase 3Homo sapiens (human)2.7

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (5.56)18.2507
2000's12 (66.67)29.6817
2010's5 (27.78)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bhat, AN; Bhat, NR; Zhang, P1
Duan, J; Norby, FL; Relling, DP; Ren, J; Wold, LE1
Ho, YS; Lee, HM; Lin, CH; Thum, WY; Wu, CH1
Choi, SH; Kim, EM; Kim, HS; Kim, S; Lee, S; Lee, SH; Min, K; Park, CH; Rah, JC; Seo, JH; Shin, JK; Suh, SW; Suh, YH1
Slomiany, A; Slomiany, BL1
Aberle, NS; Hintz, KK; Ren, J1
Collyer, E; De la Cerda, P; Decap, V; Rodriguez, JA; Velarde, V; Vio, CP1
Arcand, M; du Souich, P; Fradette, C; Kourylko, O1
Ea, HK; Lioté, F; Rey, C; Uzan, B1
Balakrishnan, A; Malladi, V; Puthenedam, M; Williams, PH1
Ikejima, T; Onodera, S; Tashiro, S; Wu, LJ; Yang, J1
Ba, ZF; Bland, KI; Chaudry, IH; Chen, J; Choudhry, MA; Hsu, JT; Kan, WH; Schwacha, MG1
Ceylan-Isik, AF; Esberg, LB; Relling, DP; Ren, J; Zhu, BH1
Baird, AW; Collins, D; Hogan, AM; Sheehan, K; Winter, DC; Zierau, O1
Fan, Y; Fu, G; Qiu, F; Xu, S; Yu, L; Zhao, Y1
Akamine, EH; Aragão, DS; Carvalho, MH; Casarini, DE; Filgueira, FP; Fortes, ZB; Hagihara, GN; Lobato, NS1
Kang, JW; Lee, SM; Shin, JK1
Eder, C; Miralles, F; Schilling, T; Spencer, NG1

Other Studies

18 other study(ies) available for sb 203580 and ng-nitroarginine methyl ester

ArticleYear
Cytokine induction of inducible nitric oxide synthase in an oligodendrocyte cell line: role of p38 mitogen-activated protein kinase activation.
    Journal of neurochemistry, 1999, Volume: 72, Issue:2

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Culture Media; Cytokines; Cytotoxins; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Imidazoles; Interferon-gamma; Interleukin-1; Mitogen-Activated Protein Kinases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oligodendroglia; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; RNA, Messenger; Tumor Necrosis Factor-alpha

1999
Abrogated leptin-induced cardiac contractile response in ventricular myocytes under spontaneous hypertension: role of Jak/STAT pathway.
    Hypertension (Dallas, Tex. : 1979), 2002, Volume: 39, Issue:1

    Topics: Animals; Blood Pressure; Calcium; Carrier Proteins; Cell Size; DNA-Binding Proteins; Enzyme Inhibitors; Heart Ventricles; Hypertension; Imidazoles; Janus Kinase 2; Leptin; Mitogen-Activated Protein Kinase Kinases; Myocardial Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Cell Surface; Receptors, Leptin; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Tyrphostins; Ventricular Dysfunction, Left

2002
Involvement of p38 mitogen-activated protein kinase in PLL-AGE-induced cyclooxgenase-2 expression.
    European journal of pharmacology, 2002, Mar-08, Volume: 438, Issue:3

    Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Dose-Response Relationship, Drug; Enzyme Activation; Genistein; Glycation End Products, Advanced; Imidazoles; Isoenzymes; Lipopolysaccharides; Mitogen-Activated Protein Kinases; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Polylysine; Polymyxin B; Prostaglandin-Endoperoxide Synthases; Pyridines; Reactive Oxygen Species

2002
Alpha-synuclein regulates neuronal survival via Bcl-2 family expression and PI3/Akt kinase pathway.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2002, Volume: 16, Issue:13

    Topics: alpha-Synuclein; Animals; Blotting, Western; Cell Line; Cell Survival; Cells, Cultured; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Morpholines; Nerve Tissue Proteins; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyridines; Rats; RNA, Messenger; Signal Transduction; Synucleins; Time Factors; Tumor Cells, Cultured

2002
Porphyromonas gingivalis lipopolysaccharide interferes with salivary mucin synthesis through inducible nitric oxide synthase activation by ERK and p38 kinase.
    Biochemical and biophysical research communications, 2002, Oct-11, Volume: 297, Issue:5

    Topics: Animals; Apoptosis; Caspase 3; Caspases; Cell Survival; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; Lipopolysaccharides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Mucins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Porphyromonas gingivalis; Pyridines; Rats; Rats, Sprague-Dawley; Saliva; Up-Regulation

2002
Insulin resistance induces hyperleptinemia, cardiac contractile dysfunction but not cardiac leptin resistance in ventricular myocytes.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 2003, Volume: 27, Issue:10

    Topics: Animals; Blood Glucose; Calcium; Enzyme Inhibitors; Glucose Tolerance Test; Imidazoles; Insulin Resistance; Leptin; Male; Myocardial Contraction; Myocytes, Cardiac; NG-Nitroarginine Methyl Ester; Pyridines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Tyrphostins; Ventricular Function

2003
Cyclooxygenase-2 induction by bradykinin in aortic vascular smooth muscle cells.
    American journal of physiology. Heart and circulatory physiology, 2006, Volume: 290, Issue:1

    Topics: Adenylyl Cyclase Inhibitors; Animals; Aorta; Bradykinin; Bradykinin B2 Receptor Antagonists; Butadienes; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 2; Dideoxyadenosine; Enzyme Induction; Imidazoles; Immunohistochemistry; Isoquinolines; Male; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Bradykinin B2; Sulfonamides

2006
Modulation of CYP1A2 and CYP3A6 catalytic activities by serum from rabbits with a turpentine-induced inflammatory reaction and interleukin 6.
    Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:1

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Catalysis; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; Hepatocytes; Imidazoles; Immune Sera; Inflammation; Interleukin-6; Male; Mitogen-Activated Protein Kinase 1; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pyridines; Rabbits; Signal Transduction; Turpentine

2006
Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes.
    Arthritis research & therapy, 2005, Volume: 7, Issue:5

    Topics: Animals; Calcium Phosphates; Cartilage, Articular; Cattle; Cells, Cultured; Chondrocytes; Crystallization; Enzyme Induction; Flavonoids; Imidazoles; Interleukin-1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 9; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Organ Culture Techniques; p38 Mitogen-Activated Protein Kinases; Protein Biosynthesis; Pyridines; RNA, Messenger; Transcription, Genetic

2005
Enteropathogenic Escherichia coli outer membrane proteins induce iNOS by activation of NF-kappaB and MAP kinases.
    Inflammation, 2004, Volume: 28, Issue:6

    Topics: Bacterial Outer Membrane Proteins; Caco-2 Cells; Electrophoretic Mobility Shift Assay; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Escherichia coli; Flavonoids; Humans; Imidazoles; Luminescent Measurements; Mitogen-Activated Protein Kinases; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitriles; Nitrites; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfones

2004
Nitric oxide activated by p38 and NF-kappaB facilitates apoptosis and cell cycle arrest under oxidative stress in evodiamine-treated human melanoma A375-S2 cells.
    Free radical research, 2008, Volume: 42, Issue:1

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Activation; Feedback, Physiological; Humans; Imidazoles; Melanoma; Membrane Potential, Mitochondrial; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Plant Extracts; Protein Kinase Inhibitors; Pyridines; Pyrrolidines; Quinazolines; Reactive Oxygen Species; Signal Transduction; Thiocarbamates; Time Factors; Tumor Suppressor Protein p53

2008
p38 MAPK-dependent eNOS upregulation is critical for 17beta-estradiol-mediated cardioprotection following trauma-hemorrhage.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:6

    Topics: Abdomen; Animals; Calmodulin; Cardiotonic Agents; Caveolin 1; Chemokine CXCL1; Chemokine CXCL2; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Estradiol; Heart Diseases; Imidazoles; Intercellular Adhesion Molecule-1; Interleukin-6; Male; Mitogen-Activated Protein Kinase 11; Myocardium; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Peroxidase; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation; Ventricular Function

2008
High-fat diet-induced obesity leads to resistance to leptin-induced cardiomyocyte contractile response.
    Obesity (Silver Spring, Md.), 2008, Volume: 16, Issue:11

    Topics: Animals; Calcium; Cells, Cultured; Diet, Fat-Restricted; Dietary Fats; Enzyme Inhibitors; Imidazoles; Leptin; Male; Myocardial Contraction; Myocardium; Myocytes, Cardiac; NG-Nitroarginine Methyl Ester; Obesity; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Leptin; Tyrphostins

2008
Rapid effects of phytoestrogens on human colonic smooth muscle are mediated by oestrogen receptor beta.
    Molecular and cellular endocrinology, 2010, May-14, Volume: 320, Issue:1-2

    Topics: Butadienes; Colon; Cycloheximide; Estradiol; Estrogen Receptor beta; Fulvestrant; Humans; Imidazoles; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitriles; Phytoestrogens; Pyridines; Reproducibility of Results; Tissue Survival

2010
Down-regulation of connexin43 gap junction by serum deprivation in human endothelial cells was improved by (-)-Epigallocatechin gallate via ERK MAP kinase pathway.
    Biochemical and biophysical research communications, 2011, Jan-07, Volume: 404, Issue:1

    Topics: Catechin; Cells, Cultured; Chromones; Connexin 43; Culture Media, Serum-Free; Down-Regulation; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gap Junctions; Humans; Imidazoles; Morpholines; NG-Nitroarginine Methyl Ester; Pyridines; RNA, Small Interfering; Signal Transduction

2011
Upregulation of ERK1/2-eNOS via AT2 receptors decreases the contractile response to angiotensin II in resistance mesenteric arteries from obese rats.
    PloS one, 2014, Volume: 9, Issue:8

    Topics: Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Animals; Blotting, Western; Endothelium, Vascular; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Male; Mesenteric Arteries; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Obesity; Phosphorylation; Pyridines; Rats, Wistar; Receptor, Angiotensin, Type 2; Up-Regulation; Vasoconstriction; Vasoconstrictor Agents

2014
Enhanced nitric oxide-mediated autophagy contributes to the hepatoprotective effects of ischemic preconditioning during ischemia and reperfusion.
    Nitric oxide : biology and chemistry, 2016, 08-31, Volume: 58

    Topics: Animals; Autophagy; Chloroquine; Guanidines; Imidazoles; Ischemia; Ischemic Preconditioning; Liver; Liver Diseases; Male; Mice, Inbred C57BL; Microtubule-Associated Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Pyridines; Reperfusion Injury

2016
Mechanisms Underlying Interferon-γ-Induced Priming of Microglial Reactive Oxygen Species Production.
    PloS one, 2016, Volume: 11, Issue:9

    Topics: Acetylcysteine; Adenosine Triphosphate; Animals; Cell Line; Enzyme Inhibitors; Gene Expression Regulation; Glutathione; Glycoproteins; Imidazoles; Interferon-gamma; Membrane Glycoproteins; Mice; Microglia; NADPH Oxidase 2; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Phenanthrolines; Potassium Channels, Inwardly Rectifying; Pyridines; Reactive Oxygen Species; Signal Transduction

2016