sb 203580 has been researched along with n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide in 17 studies
| Studies (sb 203580) | Trials (sb 203580) | Recent Studies (post-2010) (sb 203580) | Studies (n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide) | Trials (n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide) | Recent Studies (post-2010) (n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide) |
|---|---|---|---|---|---|
| 3,489 | 4 | 1,137 | 1,220 | 3 | 229 |
| Protein | Taxonomy | sb 203580 (IC50) | n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide (IC50) |
|---|---|---|---|
| Prostaglandin E synthase | Homo sapiens (human) | 10 | |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | 2.1 | |
| Aromatase | Homo sapiens (human) | 0.68 | |
| Prostaglandin G/H synthase 1 | Mus musculus (house mouse) | 1.67 | |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | 3 | |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | 0.9037 | |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | 2.4333 | |
| Prostaglandin G/H synthase 2 | Mus musculus (house mouse) | 0.1522 | |
| Carboxypeptidase B2 | Homo sapiens (human) | 1.8 | |
| Prostaglandin E synthase | Mus musculus (house mouse) | 0.007 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (52.94) | 29.6817 |
| 2010's | 8 (47.06) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Askari, FK; Crofford, LJ; Pausawasdi, N; Ramamoorthy, S; Todisco, A | 1 |
| Demetris, AJ; Han, C; Lunz, JG; Michalopoulos, G; Shelhamer, JH; Wu, T | 1 |
| Buresi, MC; Buret, AG; Hollenberg, MD; MacNaughton, WK | 1 |
| Harada, R; Kobayashi, M; Nakata, H; Taguchi, H; Uemura, Y | 1 |
| Akahoshi, M; Arinobu, Y; Harada, M; Inoue, Y; Miyake, K; Nagano, S; Nakashima, H; Niiro, H; Ninomiya, I; Ogami, E; Otsuka, T; Shimizu, S | 1 |
| Chang, YC; Hsieh, YS; Huang, FM; Liu, CM; Yang, LC; Yang, SF | 1 |
| Kim, H; Kokkotou, E; LaMont, JT; Moyer, MP; Na, X; Pothoulakis, C; Rhee, SH; Savidge, T | 1 |
| Laham, R; Li, J; Luo, J; Rana, JS; Sellke, FW; Wu, G | 1 |
| Kadonosono, K; Kamei, J; Ohnaka, K; Tanaka, S; Utsunomiya, H; Yamakawa, T | 1 |
| Chang, HW; Hung, SL; Lai, YL; Lee, YY; Liu, TY; Wu, CY | 1 |
| Kondo, A; Matsuda, T; Togari, A; Tsunashima, Y | 1 |
| Chang, YC; Ho, YC; Lee, SS; Tsai, CH; Yu, CC | 1 |
| Nemoto, E; Shimauchi, H; Suzuki, R | 1 |
| Fu, X; Li, Q; Liu, N; Liu, X; Sui, H; Wang, Y; Wu, Q; Ye, N; Yu, NA; Zhou, L; Zhou, N | 1 |
| Chang, W; Han, HJ; Jeon, YJ; Kim, HS; Lee, MY; Park, SH; Song, KS | 1 |
| Chen, J; Feng, J; Guo, R; He, J; Liu, C; Lu, Y; Zhang, W; Zhang, Y; Zhen, Y | 1 |
| Gao, FH; Liu, H; Tang, MC; Xu, XF; Zhao, Y; Zhou, YQ | 1 |
17 other study(ies) available for sb 203580 and n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide
| Article | Year |
|---|---|
Regulation and function of COX-2 gene expression in isolated gastric parietal cells.
Topics: Animals; Carbachol; Cells, Cultured; Cholinergic Agonists; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dogs; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Histamine; Imidazoles; Indoles; Isoenzymes; Maleimides; NF-kappa B; Nitrobenzenes; Parietal Cells, Gastric; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyridines; Sulfonamides | 2002 |
Involvement of 85-kd cytosolic phospholipase A(2) and cyclooxygenase-2 in the proliferation of human cholangiocarcinoma cells.
Topics: Arachidonic Acids; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Division; Cholangiocarcinoma; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytosol; Dinoprost; Dinoprostone; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Humans; Imidazoles; Interleukin-6; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinases; Nitrobenzenes; Organophosphonates; Phospholipases A; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; Sulfonamides; Tumor Cells, Cultured | 2002 |
Activation of proteinase-activated receptor 1 stimulates epithelial chloride secretion through a unique MAP kinase- and cyclo-oxygenase-dependent pathway.
Topics: Androstadienes; Butadienes; Cell Line; Chlorides; Epithelial Cells; Humans; Imidazoles; Indoles; Maleimides; Mitogen-Activated Protein Kinases; Nitriles; Nitrobenzenes; Phospholipases A; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Pyridines; Pyrimidines; Quinazolines; Receptor, PAR-1; Receptors, Thrombin; Signal Transduction; Sulfonamides; Thrombin; Tyrphostins; Wortmannin | 2002 |
Cyclooxygenase-2 inhibitor NS-398 suppresses cell growth and constitutive production of granulocyte-colony stimulating factor and granulocyte macrophage-colony stimulating factor in lung cancer cells.
Topics: Cell Division; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Progression; Drug Screening Assays, Antitumor; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imidazoles; Interleukin-1; Isoenzymes; Lung Neoplasms; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Proteins; NF-kappa B; Nitrobenzenes; Proline; Prostaglandin-Endoperoxide Synthases; Pyridines; Recombinant Proteins; Sulfonamides; Thiocarbamates; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2003 |
Novel regulatory mechanisms of CD40-induced prostanoid synthesis by IL-4 and IL-10 in human monocytes.
Topics: Antibodies, Monoclonal; Carrier Proteins; CD40 Antigens; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Flavonoids; Humans; Imidazoles; Interleukin-10; Interleukin-4; Isoenzymes; Ligands; MAP Kinase Signaling System; Membrane Proteins; Monocytes; NF-kappa B; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Protein Transport; Pyridines; Recombinant Proteins; Repressor Proteins; Sulfonamides | 2004 |
Examination of the signal transduction pathways involved in matrix metalloproteinases-2 in human pulp cells.
Topics: Benzoquinones; Butadienes; Cells, Cultured; Chromones; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dental Pulp; Dexamethasone; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Isoenzymes; Lactams, Macrocyclic; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; NF-kappa B; Nitriles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Pyridines; Quinones; Rifabutin; Signal Transduction; Sulfonamides | 2004 |
Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK.
Topics: Animals; Bacterial Toxins; Cell Line; Colon; Cyclic AMP; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enterotoxins; Enzyme Activation; Enzyme Inhibitors; Humans; Ileum; Imidazoles; Immunohistochemistry; Inflammation; Intramolecular Oxidoreductases; Luciferases; Membrane Proteins; Mice; Mice, SCID; Models, Biological; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostaglandin-E Synthases; Prostaglandin-Endoperoxide Synthases; Protein Binding; Pyridines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Signal Transduction; Sulfonamides; Time Factors; Tissue Transplantation; Transfection | 2005 |
Involvement of COX-2 in VEGF-induced angiogenesis via P38 and JNK pathways in vascular endothelial cells.
Topics: Anthracenes; Butadienes; Cells, Cultured; Cyclooxygenase 2; Endothelial Cells; Endothelium, Vascular; Gene Deletion; Humans; Imidazoles; MAP Kinase Kinase 4; Membrane Proteins; Neovascularization, Physiologic; Nitriles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; RNA, Small Interfering; Signal Transduction; Sulfonamides; Vascular Endothelial Growth Factor A | 2006 |
Cyclooxygenase-2 induction by lysophosphatidylcholine in cultured rat vascular smooth muscle cells: involvement of the p38MAPK pathway.
Topics: Animals; Cells, Cultured; Culture Media, Serum-Free; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Induction; Flavonoids; Imidazoles; Lysophosphatidylcholines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfonamides | 2008 |
Stimulatory effects of areca nut extracts on prostaglandin E2 production by human polymorphonuclear leukocytes.
Topics: Adult; Areca; Blotting, Western; Butadienes; Calcium; Cell Survival; Cells, Cultured; Chelating Agents; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Imidazoles; Inflammation Mediators; Male; Neutrophils; Nitriles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Plant Extracts; Pyridines; Sulfonamides; Young Adult | 2010 |
Inhibitory effect of vitamin K(2) on interleukin-1beta-stimulated proliferation of human osteoblasts.
Topics: Adult; Anticoagulants; Bone Neoplasms; Cell Line; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Flavonoids; Glutamic Acid; Humans; Imidazoles; Interleukin-1; Interleukin-1beta; Male; Mitogen-Activated Protein Kinase Kinases; Nitrobenzenes; Osteoblasts; Osteocalcin; Osteosarcoma; p38 Mitogen-Activated Protein Kinases; Pregnane X Receptor; Protein Kinase Inhibitors; Pyridines; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; RNA, Messenger; Sulfonamides; Vitamin K; Vitamins; Warfarin; Young Adult | 2010 |
Heat shock protein 27 expression in areca quid chewing-associated oral squamous cell carcinomas.
Topics: Acetylcysteine; Areca; Arecoline; Carcinoma, Squamous Cell; Case-Control Studies; Catechin; Cyclooxygenase 2 Inhibitors; Down-Regulation; Female; Flavonoids; Gene Expression; Gene Expression Regulation, Neoplastic; HSP27 Heat-Shock Proteins; Humans; Imidazoles; Male; Middle Aged; Mouth Neoplasms; Nitrobenzenes; Pyridines; Quercetin; Sulfonamides | 2012 |
Cyclic tensile force up-regulates BMP-2 expression through MAP kinase and COX-2/PGE2 signaling pathways in human periodontal ligament cells.
Topics: Adult; Bite Force; Bone Morphogenetic Protein 2; Butadienes; Calcification, Physiologic; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Humans; Imidazoles; Male; Mastication; Molar, Third; Nitriles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Stress, Physiological; Sulfonamides; Up-Regulation; Young Adult | 2014 |
Helicobacter pylori promotes VEGF expression via the p38 MAPK‑mediated COX‑2‑PGE2 pathway in MKN45 cells.
Topics: Cell Line, Tumor; Cyclooxygenase 2; Dinoprostone; HEK293 Cells; Helicobacter pylori; Humans; Imidazoles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; RNA Interference; RNA, Small Interfering; Sulfonamides; Up-Regulation; Vascular Endothelial Growth Factor A | 2014 |
Protective effect of dieckol against chemical hypoxia-induced cytotoxicity in primary cultured mouse hepatocytes.
Topics: Animals; Benzofurans; Cell Hypoxia; Cell Survival; Cells, Cultured; Cobalt; Cyclooxygenase 2; Dose-Response Relationship, Drug; Hepatocytes; Imidazoles; Male; Mice; Mice, Inbred ICR; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; Sulfonamides; Time Factors | 2015 |
Exogenous hydrogen sulfide promotes C6 glioma cell growth through activation of the p38 MAPK/ERK1/2-COX-2 pathways.
Topics: Animals; Brain Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclooxygenase 2; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glioma; Hydrogen Sulfide; Imidazoles; MAP Kinase Signaling System; Nitrobenzenes; Phosphorylation; Protein Processing, Post-Translational; Pyridines; Rats; Sulfonamides | 2015 |
NS-398 promotes pancreatic cancer cell invasion by CD147 and MMP-2 via the activation of P38.
Topics: Basigin; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Humans; Imidazoles; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Pyridines; RNA, Small Interfering; Sulfonamides | 2016 |