sb 203580 has been researched along with morphine in 13 studies
| Studies (sb 203580) | Trials (sb 203580) | Recent Studies (post-2010) (sb 203580) | Studies (morphine) | Trials (morphine) | Recent Studies (post-2010) (morphine) |
|---|---|---|---|---|---|
| 3,489 | 4 | 1,137 | 44,270 | 5,200 | 8,695 |
| Protein | Taxonomy | sb 203580 (IC50) | morphine (IC50) |
|---|---|---|---|
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.2939 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.2278 | |
| Kappa-type opioid receptor | Mus musculus (house mouse) | 0.0828 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0385 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0545 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.122 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.1199 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.9308 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.655 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.3305 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.202 | |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | 0.25 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 6 (46.15) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, PX; Chen, Y; Cui, Y; Feng, JQ; Guo, RX; Zhi, JL | 1 |
| Cheng, CW; Sun, HS; Tseng, LF; Wu, HE | 1 |
| Chen, ZW; Gu, EW; Zhang, J; Zhang, Y | 1 |
| Hsin, ST; Lin, SL; Shen, CH; Tai, YH; Tsai, RY; Tzeng, JI; Wang, CB; Wong, CS; Yang, CP | 1 |
| Lin, SL; Tai, YH; Tao, PL; Tsai, RY; Wang, JJ; Wong, CS; Yeh, CC | 1 |
| Cui, Y; Jing, J; Liu, X; Xin, W; Zhang, X | 1 |
| Chen, L; Hanley, G; He, L; Jiang, Y; LeSage, G; Li, H; Li, Y; Miao, J; Peng, Y; Xiao, Z; Yin, D; Zhang, X; Zhang, Y | 1 |
| Chabot, JG; Quirion, R; Wang, Z | 1 |
| Chen, FY; Chen, Y; Cui, Y; Li, YY; Liu, XG; Na, XD; Wei, XH; Xin, WJ; Zhang, XQ | 1 |
| Cao, M; Ji, F; Liang, J; Liu, F; Liu, L; Wang, T; Wu, Q | 1 |
| Do, SH; Han, SH; Ryu, JH; Zuo, Z | 1 |
| Gao, F; Jia, X; Li, Z; Peng, X; Tian, X; Zhang, A | 1 |
| Chen, Y; Fan, R; Gong, X; Ye, X; Zhang, M; Zhu, Q | 1 |
13 other study(ies) available for sb 203580 and morphine
| Article | Year |
|---|---|
Activation of p38 mitogen-activated protein kinase in spinal microglia mediates morphine antinociceptive tolerance.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; CD11b Antigen; Cell Count; Drug Administration Schedule; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Imidazoles; Immunohistochemistry; Male; Microglia; Morphine; Morphine Dependence; p38 Mitogen-Activated Protein Kinases; Phosphopyruvate Hydratase; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Time Factors | 2006 |
p38 mitogen-activated protein kinase inhibitor SB203580 reverses the antianalgesia induced by dextro-morphine or morphine in the mouse spinal cord.
Topics: Analgesics, Opioid; Animals; Enzyme Inhibitors; Imidazoles; Male; Mice; Morphine; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pyridines; Reaction Time; Spinal Cord; Stereoisomerism | 2006 |
Role of p38 mitogen-activated protein kinases in cardioprotection of morphine preconditioning.
Topics: Animals; Blotting, Western; Heart; Imidazoles; Ischemic Preconditioning; Male; MAP Kinase Signaling System; Morphine; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley | 2007 |
Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats and prevents glutamate transporter downregulation by suppressing the p38 mitogen-activated protein kinase signaling pathway.
Topics: Amino Acid Transport System X-AG; Animals; Enzyme Inhibitors; Excitatory Amino Acids; Hyperalgesia; Imidazoles; Male; MAP Kinase Signaling System; Microglia; Morphine; Naloxone; Narcotic Antagonists; Narcotics; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Pyridines; Random Allocation; Rats; Rats, Wistar; Spinal Cord | 2009 |
Amitriptyline suppresses neuroinflammation-dependent interleukin-10-p38 mitogen-activated protein kinase-heme oxygenase-1 signaling pathway in chronic morphine-infused rats.
Topics: Amitriptyline; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Blocking; Antidepressive Agents, Tricyclic; Drug Tolerance; Enzyme Inhibitors; Heme Oxygenase-1; Imidazoles; Interleukin-10; Male; Morphine; Myelitis; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Protoporphyrins; Pyridines; Rats; Rats, Wistar; Signal Transduction; Spinal Cord | 2009 |
Involvement of p38/NF-κB signaling pathway in the nucleus accumbens in the rewarding effects of morphine in rats.
Topics: Analysis of Variance; Animals; Blotting, Western; Conditioning, Psychological; Enzyme Inhibitors; Imidazoles; Male; Morphine; NF-kappa B; Nucleus Accumbens; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Reward; Signal Transduction | 2011 |
Toll-like receptor 9 is required for opioid-induced microglia apoptosis.
Topics: Analgesics, Opioid; Animals; Apoptosis; CpG Islands; Imidazoles; Immunity, Innate; Mice; Mice, Knockout; Microglia; Morphine; Oligonucleotides; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Pyridines; Toll-Like Receptor 9 | 2011 |
On the possible role of ERK, p38 and CaMKII in the regulation of CGRP expression in morphine-tolerant rats.
Topics: Animals; Benzylamines; Calcitonin Gene-Related Peptide; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Ganglia, Spinal; Imidazoles; Immunohistochemistry; Male; Morphine; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Posterior Horn Cells; Pyridines; Rats; Rats, Sprague-Dawley; Sulfonamides | 2011 |
Activation of p38 signaling in the microglia in the nucleus accumbens contributes to the acquisition and maintenance of morphine-induced conditioned place preference.
Topics: Animals; Conditioning, Operant; Enzyme Activation; Imidazoles; Male; Microglia; Minocycline; Morphine; Nucleus Accumbens; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction | 2012 |
Effect of c-Jun N-terminal kinase (JNK)/p38 mitogen-activated protein kinase (p38 MAPK) in morphine-induced tau protein hyperphosphorylation.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anthracenes; Cells, Cultured; Cerebral Cortex; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 8; Morphine; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; tau Proteins; Time Factors | 2013 |
Morphine reduces mouse microglial engulfment induced by lipopolysaccharide and interferon-γ via δ opioid receptor and p38 mitogen-activated protein kinase.
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Anisomycin; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Imidazoles; Interferon-gamma; Lipopolysaccharides; Mice; Microglia; Morphine; Naloxone; Narcotic Antagonists; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Opioid, delta | 2018 |
Activation of spinal PDGFRβ in microglia promotes neuronal autophagy via p38 MAPK pathway in morphine-tolerant rats.
Topics: Adenine; Animals; Autophagy; Drug Tolerance; Imatinib Mesylate; Imidazoles; Injections, Spinal; Male; MAP Kinase Signaling System; Microglia; Minocycline; Morphine; Narcotics; Neurons; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Platelet-Derived Growth Factor beta | 2021 |
Exercise Reduces Morphine-Induced Hyperalgesia and Antinociceptive Tolerance.
Topics: Analgesics; Animals; Hyperalgesia; Imidazoles; Male; Morphine; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Physical Conditioning, Animal; Pyridines; Rats, Wistar; Spinal Cord Dorsal Horn | 2021 |