Page last updated: 2024-09-05

sb 203580 and morphine

sb 203580 has been researched along with morphine in 13 studies

Compound Research Comparison

Studies
(sb 203580)
Trials
(sb 203580)
Recent Studies (post-2010)
(sb 203580)
Studies
(morphine)
Trials
(morphine)
Recent Studies (post-2010) (morphine)
3,48941,13744,2705,2008,695

Protein Interaction Comparison

ProteinTaxonomysb 203580 (IC50)morphine (IC50)
Delta-type opioid receptorMus musculus (house mouse)0.2939
Delta-type opioid receptorRattus norvegicus (Norway rat)0.2278
Kappa-type opioid receptorMus musculus (house mouse)0.0828
Mu-type opioid receptorRattus norvegicus (Norway rat)0.0385
Kappa-type opioid receptorRattus norvegicus (Norway rat)0.0545
Mu-type opioid receptorHomo sapiens (human)0.122
Delta-type opioid receptorHomo sapiens (human)0.1199
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.9308
Kappa-type opioid receptorHomo sapiens (human)0.655
Mu-type opioid receptorMus musculus (house mouse)0.3305
Mu-type opioid receptorCavia porcellus (domestic guinea pig)0.202
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.25

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (38.46)29.6817
2010's6 (46.15)24.3611
2020's2 (15.38)2.80

Authors

AuthorsStudies
Chen, PX; Chen, Y; Cui, Y; Feng, JQ; Guo, RX; Zhi, JL1
Cheng, CW; Sun, HS; Tseng, LF; Wu, HE1
Chen, ZW; Gu, EW; Zhang, J; Zhang, Y1
Hsin, ST; Lin, SL; Shen, CH; Tai, YH; Tsai, RY; Tzeng, JI; Wang, CB; Wong, CS; Yang, CP1
Lin, SL; Tai, YH; Tao, PL; Tsai, RY; Wang, JJ; Wong, CS; Yeh, CC1
Cui, Y; Jing, J; Liu, X; Xin, W; Zhang, X1
Chen, L; Hanley, G; He, L; Jiang, Y; LeSage, G; Li, H; Li, Y; Miao, J; Peng, Y; Xiao, Z; Yin, D; Zhang, X; Zhang, Y1
Chabot, JG; Quirion, R; Wang, Z1
Chen, FY; Chen, Y; Cui, Y; Li, YY; Liu, XG; Na, XD; Wei, XH; Xin, WJ; Zhang, XQ1
Cao, M; Ji, F; Liang, J; Liu, F; Liu, L; Wang, T; Wu, Q1
Do, SH; Han, SH; Ryu, JH; Zuo, Z1
Gao, F; Jia, X; Li, Z; Peng, X; Tian, X; Zhang, A1
Chen, Y; Fan, R; Gong, X; Ye, X; Zhang, M; Zhu, Q1

Other Studies

13 other study(ies) available for sb 203580 and morphine

ArticleYear
Activation of p38 mitogen-activated protein kinase in spinal microglia mediates morphine antinociceptive tolerance.
    Brain research, 2006, Jan-19, Volume: 1069, Issue:1

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; CD11b Antigen; Cell Count; Drug Administration Schedule; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Imidazoles; Immunohistochemistry; Male; Microglia; Morphine; Morphine Dependence; p38 Mitogen-Activated Protein Kinases; Phosphopyruvate Hydratase; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Time Factors

2006
p38 mitogen-activated protein kinase inhibitor SB203580 reverses the antianalgesia induced by dextro-morphine or morphine in the mouse spinal cord.
    European journal of pharmacology, 2006, Nov-21, Volume: 550, Issue:1-3

    Topics: Analgesics, Opioid; Animals; Enzyme Inhibitors; Imidazoles; Male; Mice; Morphine; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pyridines; Reaction Time; Spinal Cord; Stereoisomerism

2006
Role of p38 mitogen-activated protein kinases in cardioprotection of morphine preconditioning.
    Chinese medical journal, 2007, May-05, Volume: 120, Issue:9

    Topics: Animals; Blotting, Western; Heart; Imidazoles; Ischemic Preconditioning; Male; MAP Kinase Signaling System; Morphine; Myocardium; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley

2007
Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats and prevents glutamate transporter downregulation by suppressing the p38 mitogen-activated protein kinase signaling pathway.
    Neuroscience, 2009, Apr-10, Volume: 159, Issue:4

    Topics: Amino Acid Transport System X-AG; Animals; Enzyme Inhibitors; Excitatory Amino Acids; Hyperalgesia; Imidazoles; Male; MAP Kinase Signaling System; Microglia; Morphine; Naloxone; Narcotic Antagonists; Narcotics; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Pyridines; Random Allocation; Rats; Rats, Wistar; Spinal Cord

2009
Amitriptyline suppresses neuroinflammation-dependent interleukin-10-p38 mitogen-activated protein kinase-heme oxygenase-1 signaling pathway in chronic morphine-infused rats.
    Anesthesiology, 2009, Volume: 110, Issue:6

    Topics: Amitriptyline; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Blocking; Antidepressive Agents, Tricyclic; Drug Tolerance; Enzyme Inhibitors; Heme Oxygenase-1; Imidazoles; Interleukin-10; Male; Morphine; Myelitis; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Protoporphyrins; Pyridines; Rats; Rats, Wistar; Signal Transduction; Spinal Cord

2009
Involvement of p38/NF-κB signaling pathway in the nucleus accumbens in the rewarding effects of morphine in rats.
    Behavioural brain research, 2011, Mar-17, Volume: 218, Issue:1

    Topics: Analysis of Variance; Animals; Blotting, Western; Conditioning, Psychological; Enzyme Inhibitors; Imidazoles; Male; Morphine; NF-kappa B; Nucleus Accumbens; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Reward; Signal Transduction

2011
Toll-like receptor 9 is required for opioid-induced microglia apoptosis.
    PloS one, 2011, Apr-29, Volume: 6, Issue:4

    Topics: Analgesics, Opioid; Animals; Apoptosis; CpG Islands; Imidazoles; Immunity, Innate; Mice; Mice, Knockout; Microglia; Morphine; Oligonucleotides; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Pyridines; Toll-Like Receptor 9

2011
On the possible role of ERK, p38 and CaMKII in the regulation of CGRP expression in morphine-tolerant rats.
    Molecular pain, 2011, Sep-21, Volume: 7

    Topics: Animals; Benzylamines; Calcitonin Gene-Related Peptide; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Ganglia, Spinal; Imidazoles; Immunohistochemistry; Male; Morphine; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Posterior Horn Cells; Pyridines; Rats; Rats, Sprague-Dawley; Sulfonamides

2011
Activation of p38 signaling in the microglia in the nucleus accumbens contributes to the acquisition and maintenance of morphine-induced conditioned place preference.
    Brain, behavior, and immunity, 2012, Volume: 26, Issue:2

    Topics: Animals; Conditioning, Operant; Enzyme Activation; Imidazoles; Male; Microglia; Minocycline; Morphine; Nucleus Accumbens; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction

2012
Effect of c-Jun N-terminal kinase (JNK)/p38 mitogen-activated protein kinase (p38 MAPK) in morphine-induced tau protein hyperphosphorylation.
    Behavioural brain research, 2013, Jan-15, Volume: 237

    Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anthracenes; Cells, Cultured; Cerebral Cortex; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 8; Morphine; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; tau Proteins; Time Factors

2013
Morphine reduces mouse microglial engulfment induced by lipopolysaccharide and interferon-γ via δ opioid receptor and p38 mitogen-activated protein kinase.
    Neurological research, 2018, Volume: 40, Issue:7

    Topics: Analgesics, Opioid; Animals; Animals, Newborn; Anisomycin; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Imidazoles; Interferon-gamma; Lipopolysaccharides; Mice; Microglia; Morphine; Naloxone; Narcotic Antagonists; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Opioid, delta

2018
Activation of spinal PDGFRβ in microglia promotes neuronal autophagy via p38 MAPK pathway in morphine-tolerant rats.
    Journal of neurochemistry, 2021, Volume: 158, Issue:2

    Topics: Adenine; Animals; Autophagy; Drug Tolerance; Imatinib Mesylate; Imidazoles; Injections, Spinal; Male; MAP Kinase Signaling System; Microglia; Minocycline; Morphine; Narcotics; Neurons; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Platelet-Derived Growth Factor beta

2021
Exercise Reduces Morphine-Induced Hyperalgesia and Antinociceptive Tolerance.
    BioMed research international, 2021, Volume: 2021

    Topics: Analgesics; Animals; Hyperalgesia; Imidazoles; Male; Morphine; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Physical Conditioning, Animal; Pyridines; Rats, Wistar; Spinal Cord Dorsal Horn

2021