sb 203580 and mocetinostat

Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

Topics: Animals; Cecum; Chemokine CXCL2; Enzyme Inhibitors; Extravascular Lung Water; Flavonoids; Hemorrhage; Imidazoles; In Vitro Techniques; Interleukin-6; Lipopolysaccharides; Macrophages, Alveolar; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Monokines; NF-kappa B; Peroxidase; Pyridines; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Shock, Septic; Tumor Necrosis Factor-alpha

Topics: Androstadienes; Apoptosis; Calcium Pyrophosphate; Caspase 3; Caspases; Cell Degranulation; Crystallization; DNA Fragmentation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Muramidase; Neutrophil Activation; Neutrophils; p38 Mitogen-Activated Protein Kinases; Peroxidase; Pyridines; Superoxides; Tumor Necrosis Factor-alpha; Wortmannin

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Cardiopulmonary Bypass; Enzyme Inhibitors; Imidazoles; Interleukin-1; Lung; Male; MAP Kinase Kinase 4; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Peroxidase; Polymerase Chain Reaction; Pyridines; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; RNA, Messenger; Transcription Factor AP-1; Tumor Necrosis Factor-alpha; Up-Regulation

Topics: Abdomen; Animals; Calmodulin; Cardiotonic Agents; Caveolin 1; Chemokine CXCL1; Chemokine CXCL2; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Estradiol; Heart Diseases; Imidazoles; Intercellular Adhesion Molecule-1; Interleukin-6; Male; Mitogen-Activated Protein Kinase 11; Myocardium; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Peroxidase; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation; Ventricular Function

Topics: Animals; Apoptosis; Butadienes; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cells, Cultured; Hydrogen Peroxide; Imidazoles; Lymph Nodes; Lymphocytes; Lymphoma, T-Cell; Male; Mice; Mice, Inbred C3H; Mitogen-Activated Protein Kinase Kinases; Necrosis; NF-kappa B; Nitric Oxide; Nitriles; Nitrites; omega-N-Methylarginine; p38 Mitogen-Activated Protein Kinases; Peroxidase; Protein Kinase Inhibitors; Pyridines; Superoxide Dismutase; Superoxides

Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemokine CXCL1; Chemokine CXCL2; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Imidazoles; Intercellular Adhesion Molecule-1; Interleukin-6; Liver Diseases; Male; Ondansetron; p38 Mitogen-Activated Protein Kinases; Peroxidase; Pyridines; Rats; Rats, Sprague-Dawley; Resuscitation; Serotonin Antagonists; Shock, Hemorrhagic; Tumor Necrosis Factor-alpha

Topics: Activating Transcription Factor 2; Apoptosis; Caspases; Cell Degranulation; Cells, Cultured; Coculture Techniques; Cycloheximide; Enzyme Activation; Human Umbilical Vein Endothelial Cells; Humans; Hydrogen Peroxide; Imidazoles; Inflammation Mediators; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Neutrophil Activation; Neutrophils; p38 Mitogen-Activated Protein Kinases; Paracrine Communication; Peroxidase; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha

Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Biomarkers; Ceruletide; Chaperonin 60; Disease Models, Animal; HSP70 Heat-Shock Proteins; Imidazoles; Inflammation Mediators; Lung; Mice, Inbred C57BL; Mitochondrial Proteins; p38 Mitogen-Activated Protein Kinases; Pancreas; Pancreatitis; Peroxidase; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Signal Transduction

Topics: Acute Lung Injury; Animals; Disease Models, Animal; Estrogens; Female; Imidazoles; Interleukin-6; Lung; p38 Mitogen-Activated Protein Kinases; Peroxidase; Pregnancy; Protective Agents; Pyridines; Rabbits; Shock, Hemorrhagic; Tumor Necrosis Factor-alpha

Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Cell Line; Creatinine; Glucuronidase; Heme Oxygenase-1; Heptanoic Acids; Imidazoles; Leucyl Aminopeptidase; Male; Malondialdehyde; Oxazoles; p38 Mitogen-Activated Protein Kinases; Peroxidase; Phosphorylation; PPAR alpha; Promoter Regions, Genetic; Protoporphyrins; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Lipoxin; Reperfusion Injury; RNA, Messenger; Tyrosine

Topics: Animals; Burns; Chemokine CCL2; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Imidazoles; Inflammation; Interleukin-1beta; Interleukin-6; Macrophages; Male; MAP Kinase Signaling System; Metallothionein; Mice; Mice, Inbred C57BL; Mice, Knockout; p38 Mitogen-Activated Protein Kinases; Peroxidase; Pyridines; Real-Time Polymerase Chain Reaction; RNA, Messenger; Tumor Necrosis Factor-alpha

Topics: Animals; Anti-Inflammatory Agents; Benzoxazines; Cannabinoid Receptor Agonists; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Female; Imidazoles; Interleukin-6; Male; Mice, Inbred C57BL; Morpholines; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Peroxidase; Protein Kinase Inhibitors; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Signal Transduction; Tumor Necrosis Factor-alpha

Topics: Acute Disease; Amylases; Animals; Calcitonin Gene-Related Peptide; Cytokines; Disease Progression; Enzyme Inhibitors; Imidazoles; Inflammation; Interleukin-1beta; Interleukin-6; Interleukin-8; Lipase; Malondialdehyde; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pancreas; Pancreatitis; Peptide Fragments; Peroxidase; Pyridines; Random Allocation; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Signal Transduction; Tumor Necrosis Factor-alpha