sb 203580 and minocycline
sb 203580 has been researched along with minocycline in 14 studies
Compound Research Comparison
| Studies (sb 203580) | Trials (sb 203580) | Recent Studies (post-2010) (sb 203580) | Studies (minocycline) | Trials (minocycline) | Recent Studies (post-2010) (minocycline) |
|---|---|---|---|---|---|
| 3,489 | 4 | 1,137 | 6,579 | 502 | 2,921 |
Protein Interaction Comparison
| Protein | Taxonomy | sb 203580 (IC50) | minocycline (IC50) |
|---|---|---|---|
| Multidrug transporter MdfA | Escherichia coli K-12 | 2.6 |
Research
Studies (14)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 8 (57.14) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Fiebich, BL; Goldsteins, G; Keinanen, R; Koistinaho, J; Tikka, T | 1 |
| Bales, KR; Bymaster, FP; Chernet, E; Dodel, RC; Du, Y; Gao, F; Lin, S; Luecke, S; Ma, Z; Nelson, DL; Paul, SM; Perry, KW; Phebus, LA; Triarhou, LC | 1 |
| Bhat, NR; Guo, G | 1 |
| Bradesi, S; Mayer, EA; Pothoulakis, C; Steinauer, J; Svensson, CI; Yaksh, TL | 1 |
| Ito, N; Obata, H; Saito, S | 1 |
| Chen, FY; Chen, Y; Cui, Y; Li, YY; Liu, XG; Na, XD; Wei, XH; Xin, WJ; Zhang, XQ | 1 |
| Ahn, DK; Bae, YC; Ju, JS; Kang, YM; Lee, MK; Park, MK; Won, KA | 1 |
| Lyons, D; Ma, F; Westlund, KN; Zhang, L | 1 |
| Ho, I; Kotani, J; Mei, XP; Sakuma, Y; Wu, D; Xie, C; Xu, LX | 1 |
| Chen, C; Meng, QX; Qi, J; Wu, H; Wu, Y; Zhao, TB | 1 |
| Chen, CH; Chen, NF; Chen, WF; Feng, CW; Huang, SY; Sung, CS; Wen, ZH; Wong, CS | 1 |
| Domoto, R; Kawabata, A; Nakashima, K; Nishibori, M; Sekiguchi, F; Tsubota, M; Wake, H; Yamanishi, H; Yamasoba, D | 1 |
| Beggs, S; Moriarty, O; Salter, MW; Sengar, AS; Tu, Y; Walker, SM | 1 |
| Gao, F; Jia, X; Li, Z; Peng, X; Tian, X; Zhang, A | 1 |
Other Studies
14 other study(ies) available for sb 203580 and minocycline
| Article | Year |
|---|---|
Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia.
Topics: Animals; Anti-Bacterial Agents; Cell Death; Cell Division; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acids; Glutamic Acid; Hydro-Lyases; Imidazoles; Kainic Acid; Microglia; Minocycline; Mitogen-Activated Protein Kinases; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Wistar; Spinal Cord | 2001 |
Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease.
Topics: Animals; Caspase 1; Cells, Cultured; Dopamine; Humans; Imidazoles; Male; Mice; Mice, Inbred C57BL; Minocycline; Mitogen-Activated Protein Kinases; Monoamine Oxidase; MPTP Poisoning; Nerve Degeneration; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Parkinsonian Disorders; Phosphorylation; Pyridines; Visual Cortex | 2001 |
p38alpha MAP kinase mediates hypoxia-induced motor neuron cell death: a potential target of minocycline's neuroprotective action.
Topics: Anti-Bacterial Agents; Blotting, Western; Cell Death; Cell Hypoxia; Cell Line; Cells, Cultured; Enzyme Inhibitors; Flow Cytometry; Glucose; Humans; Imidazoles; L-Lactate Dehydrogenase; Minocycline; Motor Neurons; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering | 2007 |
Role of spinal microglia in visceral hyperalgesia and NK1R up-regulation in a rat model of chronic stress.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Imidazoles; Male; Microglia; Minocycline; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Spinal Nerves; Stress, Physiological; Up-Regulation; Viscera; Water Deprivation | 2009 |
Spinal microglial expression and mechanical hypersensitivity in a postoperative pain model: comparison with a neuropathic pain model.
Topics: Animals; Anti-Bacterial Agents; Behavior, Animal; CD11b Antigen; Enzyme Inhibitors; Fluorescent Antibody Technique; Hyperalgesia; Imidazoles; Immunohistochemistry; Male; Microglia; Minocycline; p38 Mitogen-Activated Protein Kinases; Pain; Pain, Postoperative; Peripheral Nervous System Diseases; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Nerves | 2009 |
Activation of p38 signaling in the microglia in the nucleus accumbens contributes to the acquisition and maintenance of morphine-induced conditioned place preference.
Topics: Animals; Conditioning, Operant; Enzyme Activation; Imidazoles; Male; Microglia; Minocycline; Morphine; Nucleus Accumbens; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction | 2012 |
Participation of microglial p38 MAPK in formalin-induced temporomandibular joint nociception in rats.
Topics: Analysis of Variance; Animals; Arthralgia; Cisterna Magna; Endpoint Determination; Formaldehyde; Imidazoles; Injections, Intra-Articular; Male; Microglia; Minocycline; Motor Activity; Nociception; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Posterior Horn Cells; Protease Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Temporomandibular Joint; Temporomandibular Joint Disorders | 2012 |
Orofacial neuropathic pain mouse model induced by Trigeminal Inflammatory Compression (TIC) of the infraorbital nerve.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Facial Pain; Hyperalgesia; Imidazoles; Inflammation; Male; Mice; Mice, Inbred C57BL; Microglia; Minocycline; Nerve Compression Syndromes; Neuralgia; Neurons; Orbit; p38 Mitogen-Activated Protein Kinases; Purinergic P2X Receptor Antagonists; Pyridines; Tetrazoles; Trigeminal Ganglion; Trigeminal Nerve; Trigeminal Neuralgia; Trigeminal Nucleus, Spinal | 2012 |
Depressing interleukin-1β contributed to the synergistic effects of tramadol and minocycline on spinal nerve ligation-induced neuropathic pain.
Topics: Analgesics; Animals; Antibodies; Drug Combinations; Hyperalgesia; Imidazoles; Interleukin-1beta; Ligation; Male; Microglia; Minocycline; Neuralgia; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Posterior Horn Cells; Pyridines; Rats, Sprague-Dawley; Rotarod Performance Test; Signal Transduction; Spinal Nerves; Tramadol | 2014 |
Crosstalk between Activated Microglia and Neurons in the Spinal Dorsal Horn Contributes to Stress-induced Hyperalgesia.
Topics: Animals; Genes, fos; Hyperalgesia; Imidazoles; Interleukin-6; Male; Microglia; Minocycline; Neurons; Pain; Pain Threshold; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Dorsal Horn; Stress, Physiological | 2016 |
Potentiation of spinal glutamatergic response in the neuron-glia interactions underlies the intrathecal IL-1β-induced thermal hyperalgesia in rats.
Topics: Animals; Disease Models, Animal; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Hot Temperature; Hyperalgesia; Imidazoles; Interleukin-1beta; Male; Microglia; Minocycline; Neurons; Nitric Oxide; Nociceptive Pain; Phosphorylation; Pyridines; Random Allocation; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2017 |
Paclitaxel-induced HMGB1 release from macrophages and its implication for peripheral neuropathy in mice: Evidence for a neuroimmune crosstalk.
Topics: Acetylcysteine; Animals; Antibodies; Cells, Cultured; Clodronic Acid; Coculture Techniques; Ganglia, Spinal; HMGB1 Protein; Hyperalgesia; Imidazoles; Macrophages; Male; Membrane Proteins; Mice; Minocycline; Neurons; p300-CBP Transcription Factors; Paclitaxel; Peripheral Nervous System Diseases; Phosphoproteins; Phosphorylation; Proline; Pyridines; Pyruvates; Reactive Oxygen Species; Receptor for Advanced Glycation End Products; Receptors, CXCR4; Recombinant Proteins; Sciatic Nerve; Thiocarbamates; Thrombomodulin; Up-Regulation | 2018 |
Priming of Adult Incision Response by Early-Life Injury: Neonatal Microglial Inhibition Has Persistent But Sexually Dimorphic Effects in Adult Rats.
Topics: Animals; Enzyme Inhibitors; Female; Hyperalgesia; Imidazoles; Interferon Regulatory Factors; Male; Microglia; Minocycline; Neurons; Pain; Pain Threshold; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Sex Factors; Spinal Cord | 2019 |
Activation of spinal PDGFRβ in microglia promotes neuronal autophagy via p38 MAPK pathway in morphine-tolerant rats.
Topics: Adenine; Animals; Autophagy; Drug Tolerance; Imatinib Mesylate; Imidazoles; Injections, Spinal; Male; MAP Kinase Signaling System; Microglia; Minocycline; Morphine; Narcotics; Neurons; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Platelet-Derived Growth Factor beta | 2021 |