Page last updated: 2024-09-05

sb 203580 and lactacystin

sb 203580 has been researched along with lactacystin in 7 studies

Compound Research Comparison

Studies
(sb 203580)
Trials
(sb 203580)
Recent Studies (post-2010)
(sb 203580)
Studies
(lactacystin)
Trials
(lactacystin)
Recent Studies (post-2010) (lactacystin)
3,48941,1379201155

Protein Interaction Comparison

ProteinTaxonomysb 203580 (IC50)lactacystin (IC50)
Proteasome subunit beta type-11Homo sapiens (human)0.259
Proteasome subunit alpha type-7Homo sapiens (human)0.259
Proteasome subunit beta type-1Homo sapiens (human)0.259
Proteasome subunit alpha type-1Homo sapiens (human)0.259
Proteasome subunit alpha type-2Homo sapiens (human)0.259
Proteasome subunit alpha type-3Homo sapiens (human)0.259
Proteasome subunit alpha type-4Homo sapiens (human)0.259
Proteasome subunit beta type-8Homo sapiens (human)0.259
Proteasome subunit beta type-9Homo sapiens (human)0.259
Proteasome subunit alpha type-5Homo sapiens (human)0.259
Proteasome subunit beta type-4Homo sapiens (human)0.259
Proteasome subunit beta type-6Homo sapiens (human)0.259
Proteasome subunit beta type-5Homo sapiens (human)1.2498
Proteasome subunit beta type-10Homo sapiens (human)0.259
Proteasome subunit beta type-3Homo sapiens (human)0.259
Proteasome subunit beta type-2Homo sapiens (human)1.7545
Proteasome subunit alpha type-6Homo sapiens (human)0.259
Splicing factor 3B subunit 3Homo sapiens (human)3.481
Proteasome subunit alpha-type 8Homo sapiens (human)0.259
Proteasome subunit beta type-7Homo sapiens (human)0.259

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (71.43)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Horwitz, KB; Lange, CA; Shen, T1
Cohen, GM; Dickens, M; MacFarlane, M1
Grant, S; Vrana, JA1
Fukuda, I; Hatakeyama, M; Imaizumi, T; Matsumiya, T; Munakata, H; Satoh, K; Shibata, T; Tamo, W; Yoshida, H1
Akaike, A; Izumi, Y; Katsuki, H; Kume, T; Sawada, H; Shimohama, S; Yamamoto, N1
Grune, T; Kästle, M; Woschee, E1
Hong, L; Huang, Z; Li, H; Miao, B; Na, N; Zhang, J; Zhao, D1

Other Studies

7 other study(ies) available for sb 203580 and lactacystin

ArticleYear
Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, Feb-01, Volume: 97, Issue:3

    Topics: Acetylcysteine; Breast Neoplasms; Consensus Sequence; Cysteine Endopeptidases; Down-Regulation; Enzyme Inhibitors; Female; Glycoproteins; HeLa Cells; Humans; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Phosphorylation; Phosphoserine; Promegestone; Proteasome Endopeptidase Complex; Protein Isoforms; Protein Processing, Post-Translational; Pyridines; Receptors, Progesterone; Recombinant Fusion Proteins; Ubiquitins

2000
JNK (c-Jun N-terminal kinase) and p38 activation in receptor-mediated and chemically-induced apoptosis of T-cells: differential requirements for caspase activation.
    The Biochemical journal, 2000, May-15, Volume: 348 Pt 1

    Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Apoptosis; Apoptosis Regulatory Proteins; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; fas Receptor; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Membrane Glycoproteins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; T-Lymphocytes; Time Factors; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha

2000
Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade.
    Blood, 2001, Apr-01, Volume: 97, Issue:7

    Topics: Acetylcysteine; Amanitins; Aminoacetonitrile; Apoptosis; Benzoquinones; Bryostatins; Butadienes; Curcumin; Cysteine Endopeptidases; Dactinomycin; Diterpenes; Drug Synergism; Enzyme Activation; Flavonoids; Humans; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; Lactones; Macrolides; Maleimides; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Nitriles; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Kinase C; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-raf; Pyridines; Quinones; Terpenes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Type C Phospholipases; U937 Cells; Ubiquitins

2001
Effect of MG132, a proteasome inhibitor, on the expression of growth related oncogene protein-alpha in human umbilical vein endothelial cells.
    Cytokine, 2003, Nov-07, Volume: 24, Issue:3

    Topics: Acetylcysteine; Anthracenes; Cells, Cultured; Chemokine CXCL1; Chemokines, CXC; Cysteine Proteinase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; I-kappa B Proteins; Imidazoles; Intercellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Leupeptins; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Umbilical Veins

2003
Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: relevance to Parkinson disease.
    The Journal of biological chemistry, 2007, Feb-16, Volume: 282, Issue:7

    Topics: Acetylcysteine; Active Transport, Cell Nucleus; Adrenergic Agents; Animals; Cell Nucleus; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Glutathione; Hydrogen Peroxide; Imidazoles; Models, Biological; NF-E2 Transcription Factor; Oxidants; Oxidative Stress; Oxidopamine; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; PC12 Cells; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyridines; Rats; Reactive Oxygen Species; Ubiquitin

2007
Histone deacetylase 6 (HDAC6) plays a crucial role in p38MAPK-dependent induction of heme oxygenase-1 (HO-1) in response to proteasome inhibition.
    Free radical biology & medicine, 2012, Dec-01, Volume: 53, Issue:11

    Topics: Acetylcysteine; Cell Survival; Cells, Cultured; Enzyme Induction; Gene Expression; Gene Knockdown Techniques; Heme Oxygenase-1; Histone Deacetylase 6; Histone Deacetylases; Homeostasis; HSP70 Heat-Shock Proteins; Humans; Imidazoles; MAP Kinase Signaling System; NF-E2-Related Factor 2; p38 Mitogen-Activated Protein Kinases; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Processing, Post-Translational; Pyridines; RNA, Small Interfering; Ubiquitin-Activating Enzymes

2012
Renoprotective effect of erythropoietin via modulation of the STAT6/MAPK/NF-κB pathway in ischemia/reperfusion injury after renal transplantation.
    International journal of molecular medicine, 2018, Volume: 41, Issue:1

    Topics: Acetylcysteine; Animals; Anthracenes; Apoptosis; Erythropoietin; Gene Expression Regulation; Humans; Imidazoles; Interferon-gamma; Kidney; Kidney Transplantation; Lentivirus; MAP Kinase Kinase 4; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pyridines; Pyrimidines; Rats; Reperfusion Injury; RNA, Small Interfering; Signal Transduction; STAT6 Transcription Factor

2018