Compounds > sb 203580
Page last updated: 2024-09-05

sb 203580 and kn 62

sb 203580 has been researched along with kn 62 in 8 studies

Compound Research Comparison

Studies
(sb 203580)		Trials
(sb 203580)		Recent Studies (post-2010)
(sb 203580)		Studies
(kn 62)		Trials
(kn 62)		Recent Studies (post-2010) (kn 62)
3,48941,137422064

Protein Interaction Comparison

ProteinTaxonomysb 203580 (IC50)kn 62 (IC50)
P2X purinoceptorCavia porcellus (domestic guinea pig)0.13
Calcium/calmodulin-dependent protein kinase type II subunit deltaHomo sapiens (human)0.38
p2X7 purinoceptor Canis lupus familiaris (dog)0.01
P2X purinoceptor 7Homo sapiens (human)0.1374
Calcium/calmodulin-dependent protein kinase type II subunit alphaHomo sapiens (human)1.03

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (50.00)29.6817
2010's4 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Caivano, M; Cohen, P; Davies, SP; Reddy, H1
Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Baldwin, SA; Caseley, EA; Fishwick, CW; Jiang, LH; Muench, SP; Simmons, K1
Choi, MR; Suh, HW; Won, JS1
Blanquet, PR; Derer, P; Mariani, J1
Clay, WC; Condreay, JP; Hall, M; Holbrook, J; Livermore, D; Michel, AD; Ng, SW; Roman, S; Senger, S; Thompson, K1
Chatterjee, S; Dua, R; Jailkhani, N; Jamal, MS; Rao, KV; Ravichandran, S1

Other Studies

8 other study(ies) available for sb 203580 and kn 62

ArticleYear
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
    The Biochemical journal, 2000, Oct-01, Volume: 351, Issue:Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides

2000
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
    The Biochemical journal, 2013, Apr-15, Volume: 451, Issue:2

    Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase

2013
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
Docking of competitive inhibitors to the P2X7 receptor family reveals key differences responsible for changes in response between rat and human.
    Bioorganic & medicinal chemistry letters, 2015, Aug-15, Volume: 25, Issue:16

    Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Binding Sites; Humans; Molecular Docking Simulation; Molecular Sequence Data; Protein Structure, Tertiary; Purinergic P2X Receptor Antagonists; Rats; Receptors, Purinergic P2X7; Sequence Alignment

2015
Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases.
    Brain research, 2001, Jun-08, Volume: 903, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Astrocytes; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cycloheximide; Enkephalins; Enzyme Inhibitors; Flavonoids; Gene Expression; Imidazoles; Isoquinolines; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Protein Precursors; Protein Synthesis Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingosine; Stimulation, Chemical; Sulfonamides; Transcription Factor AP-1

2001
A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus.
    Neuroscience, 2003, Volume: 118, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Androstadienes; Animals; Antibodies; Benzophenanthridines; Benzopyrans; Blotting, Western; Brain-Derived Neurotrophic Factor; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carbazoles; Cell Nucleus; Chromones; Cyclic AMP Response Element-Binding Protein; Cytosol; Enzyme Inhibitors; Flavonoids; Hippocampus; Imidazoles; Immunohistochemistry; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Male; Morpholines; Naphthalenes; Phenanthridines; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Rats; Signal Transduction; Time Factors; Tyrphostins; Wortmannin

2003
Identification of regions of the P2X(7) receptor that contribute to human and rat species differences in antagonist effects.
    British journal of pharmacology, 2008, Volume: 155, Issue:5

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Allosteric Regulation; Allosteric Site; Amino Acid Sequence; Animals; Cell Line; Cloning, Molecular; Dose-Response Relationship, Drug; Glycine; Humans; Imidazoles; Molecular Sequence Data; Mutagenesis, Site-Directed; Piperazines; Plasmids; Polymorphism, Single Nucleotide; Protein Binding; Protein Structure, Tertiary; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Pyridines; Pyridoxal Phosphate; Radioligand Assay; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Sequence Alignment; Species Specificity; Transfection

2008
Defining the antigen receptor-dependent regulatory network that induces arrest of cycling immature B-lymphocytes.
    BMC systems biology, 2010, Dec-09, Volume: 4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; B-Lymphocytes; Cell Cycle; Cell Line, Tumor; Feedback, Physiological; Gene Expression Profiling; Imidazoles; Mice; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Antigen, B-Cell; Signal Transduction; src-Family Kinases; Systems Biology; Transcription Factors

2010