Page last updated: 2024-09-05

sb 203580 and hts 466284

sb 203580 has been researched along with hts 466284 in 2 studies

Compound Research Comparison

Studies (sb 203580)	Trials (sb 203580)	Recent Studies (post-2010) (sb 203580)	Studies (hts 466284)	Trials (hts 466284)	Recent Studies (post-2010) (hts 466284)
3,489	4	1,137	43	0	27

Protein Interaction Comparison

Protein	Taxonomy	hts 466284 (IC50)
Chain A, TGF-beta receptor type I	Homo sapiens (human)	0.051
Chain A, TGF-beta receptor type I	Homo sapiens (human)	0.051
TGF-beta receptor type-1	Homo sapiens (human)	0.0522
TGF-beta receptor type-2	Homo sapiens (human)	0.4
Mitogen-activated protein kinase 14	Homo sapiens (human)	0.74
Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)	1.4

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Arduini, RM; Boriack-Sjodin, PA; Bowes, S; Cheung, HK; Chuaqui, CE; Corbley, MJ; Josiah, S; Lee, WC; Ling, LE; Mead, JN; Newman, MN; Papadatos, JL; Pontz, T; Singh, J	1
Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A	1

Other Studies

2 other study(ies) available for sb 203580 and hts 466284

Article	Year
Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI). Bioorganic & medicinal chemistry letters, 2003, Dec-15, Volume: 13, Issue:24 Topics: Adenosine Triphosphate; Antineoplastic Agents; Binding Sites; Drug Evaluation, Preclinical; Enzyme Inhibitors; Kinetics; Molecular Conformation; Phosphorylation; Protein Conformation; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; User-Computer Interface	2003
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. The Biochemical journal, 2013, Apr-15, Volume: 451, Issue:2 Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase	2013

Article

Year

Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI).

Bioorganic & medicinal chemistry letters, 2003, Dec-15, Volume: 13, Issue:24

Topics: Adenosine Triphosphate; Antineoplastic Agents; Binding Sites; Drug Evaluation, Preclinical; Enzyme Inhibitors; Kinetics; Molecular Conformation; Phosphorylation; Protein Conformation; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; User-Computer Interface

2003

A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

The Biochemical journal, 2013, Apr-15, Volume: 451, Issue:2

Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase

2013