Compounds > sb 203580
Page last updated: 2024-09-05

sb 203580 and h 89

sb 203580 has been researched along with h 89 in 34 studies

Compound Research Comparison

Studies
(sb 203580)		Trials
(sb 203580)		Recent Studies (post-2010)
(sb 203580)		Studies
(h 89)		Trials
(h 89)		Recent Studies (post-2010) (h 89)
3,48941,1371,6190409

Protein Interaction Comparison

ProteinTaxonomysb 203580 (IC50)h 89 (IC50)
Rho-associated protein kinase 2Homo sapiens (human)1.9504
Ribosomal protein S6 kinase alpha-5Homo sapiens (human)0.12
cAMP-dependent protein kinase catalytic subunit alphaBos taurus (cattle)0.073
cAMP-dependent protein kinase catalytic subunit alpha Mus musculus (house mouse)0.381
cAMP-dependent protein kinase catalytic subunit alphaHomo sapiens (human)0.6365
cAMP-dependent protein kinase catalytic subunit gammaHomo sapiens (human)0.6365
cAMP-dependent protein kinase catalytic subunit betaHomo sapiens (human)0.6365
Ribosomal protein S6 kinase beta-1Homo sapiens (human)0.08
RAC-alpha serine/threonine-protein kinaseHomo sapiens (human)1.9886
RAC-beta serine/threonine-protein kinaseHomo sapiens (human)0.5417
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)0.27
RAC-gamma serine/threonine-protein kinaseHomo sapiens (human)0.3207

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (2.94)18.2507
2000's25 (73.53)29.6817
2010's8 (23.53)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Caivano, M; Cohen, P; Davies, SP; Reddy, H1
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H1
Bradley, KA; Damoiseaux, R; Gillespie, EJ; Huang, J; Manchester, M; Rogers, J; Sanchez, AM; Saxe, JP; Thomas, D1
Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N1
Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M1
Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A1
Koppal, T; Lukas, TJ; Mirzoeva, S; Petrova, TV; Van Eldik, LJ; Watterson, DM1
Hirata , K; Inoue, N; Kawashima, S; Kojima, Y; Rikitake, Y; Shimokawa, Y; Takeuchi, S; Yokoyama, M1
Lee, JK; Suh, HW; Won, JS1
Choi, MR; Suh, HW; Won, JS1
Asakura, M; Asanuma, H; Fukushima, T; Hori, M; Kitakaze, M; Kuzuya, T; Liao, Y; Mori, H; Node, K; Ogai, A; Ogita, H; Papst, PJ; Sakata, Y; Sanada, S; Shinozaki, Y; Takashima, S; Terada, N; Yamada, J1
Bevilaqua, LR; Cammarota, M; Dunkley, PR; Rostas, JA1
De Wilde, G; Haegeman, G; Van Damme, P; Vanden Berghe, W; Vermeulen, L1
Gutiérrez-Sagal, R; Herrera-Muñoz, J; Pasapera Limón, AM; Ulloa-Aguirre, A1
Kageyama, K; Suda, T1
Hall, CS; McCabe, LR; Parameswaran, N; Spielman, WS1
Itoh, M; Kakita, A; Miura, Y; Oiso, Y; Ono, Y; Suzuki, A1
Chvatchko, Y; Corbaz, A; Dimmeler, S; Haendeler, J; Reinhold, J; Rochwalsky, U; Rössig, L; Seeger, FH; Urbich, C; Walter, DH; Zeiher, AM1
Hoffmann, EK; Marshall, WS; Ossum, CG1
Iijima, R; Ishida, A; Kobayashi, A; Maeda, M1
Collyer, E; De la Cerda, P; Decap, V; Rodriguez, JA; Velarde, V; Vio, CP1
Hou, M; Ling, W; Ma, J; Tang, Z; Wang, Q; Xia, M; Xiao, Y; Zhao, T; Zhu, H1
Blume, N; Friedrichsen, BN; Gram, VK; Lee, YC; Møldrup, A; Neubauer, N; Nielsen, JH; Petersen, JS1
Beales, IL; Ogunwobi, OO1
Beis, I; Gaitanaki, C; Kefaloyianni, E1
Acquaviva, AM; Acquaviva, F; di Palma, A; Di Prisco, AM; Giannouli, M; Iuliano, F; Leone, V; Ricchi, P1
Hanada, K; Iwasaki, Y; Kageyama, K; Nigawara, T; Sakihara, S; Suda, T; Takayasu, S1
Avni, D; Meijler, MM; Philosoph, A; Zor, T1
Cao, J; Du, Y; Han, X; Li, X; Liu, H; Song, K; Wang, J; Yan, L; Zhan, W1
Ping, F; Shang, J; Song, J; Zhou, J1
Guo, H; Jiang, L; Jing, H; Li, Y; Ren, F; Wang, X; Zhang, H; Zhang, W1
Goshima, H; Ishizuka, T; Ozawa, A; Watanabe, Y1
Gao, J; Jiang, Y; Lu, W; Shi, Q; Su, M; Sun, B; Xu, Y; Yang, X; Zhang, Y1
Liu, JH; Qi, XY; Ran, L; Wang, YD; Wen, GB; Xiao, XH; Xu, CX; Yang, J; Zhang, HL1

Other Studies

34 other study(ies) available for sb 203580 and h 89

ArticleYear
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
    The Biochemical journal, 2000, Oct-01, Volume: 351, Issue:Pt 1

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides

2000
Identifying off-target effects and hidden phenotypes of drugs in human cells.
    Nature chemical biology, 2006, Volume: 2, Issue:6

    Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

2006
Amiodarone and bepridil inhibit anthrax toxin entry into host cells.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:7

    Topics: Amiodarone; Animals; Anthrax; Antigens, Bacterial; Bacterial Toxins; Bepridil; Cell Line; Cell Survival; Chloroquine; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Macrophages, Peritoneal; Male; Mice; Molecular Structure; Rats; Rats, Inbred F344; Time Factors

2007
The selectivity of protein kinase inhibitors: a further update.
    The Biochemical journal, 2007, Dec-15, Volume: 408, Issue:3

    Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera

2007
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-18, Volume: 104, Issue:51

    Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

2007
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
    The Biochemical journal, 2013, Apr-15, Volume: 451, Issue:2

    Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase

2013
Screening in a cell-based assay for inhibitors of microglial nitric oxide production reveals calmodulin-regulated protein kinases as potential drug discovery targets.
    Brain research, 1999, Oct-09, Volume: 844, Issue:1-2

    Topics: Amidines; Animals; Benzylamines; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Line; Cell Nucleus; Cyclic AMP Response Element-Binding Protein; Drug Design; Enzyme Inhibitors; Flavonoids; Imidazoles; Indole Alkaloids; Isoquinolines; Lipopolysaccharides; Mice; Microglia; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Phosphorylation; Pyridines; Staurosporine; Sulfonamides

1999
Signaling mechanism underlying COX-2 induction by lysophosphatidylcholine.
    Biochemical and biophysical research communications, 2001, Volume: 281, Issue:5

    Topics: Activating Transcription Factor 1; Animals; Cattle; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; DNA-Binding Proteins; Endothelium, Vascular; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Imidazoles; Indoles; Isoenzymes; Isoquinolines; Lysophosphatidylcholines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; RNA, Messenger; Sulfonamides; Transcription Factors; Up-Regulation

2001
Forskolin inhibits expression of inducible nitric oxide synthase mRNA via inhibiting the mitogen activated protein kinase in C6 cells.
    Brain research. Molecular brain research, 2001, Apr-18, Volume: 89, Issue:1-2

    Topics: Animals; Colforsin; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Glioma; Imidazoles; Isoquinolines; Lipopolysaccharides; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; RNA, Messenger; Sulfonamides; Transcription, Genetic; Tumor Cells, Cultured

2001
Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases.
    Brain research, 2001, Jun-08, Volume: 903, Issue:1-2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Astrocytes; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cycloheximide; Enkephalins; Enzyme Inhibitors; Flavonoids; Gene Expression; Imidazoles; Isoquinolines; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Protein Precursors; Protein Synthesis Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingosine; Stimulation, Chemical; Sulfonamides; Transcription Factor AP-1

2001
Cardioprotective effect afforded by transient exposure to phosphodiesterase III inhibitors: the role of protein kinase A and p38 mitogen-activated protein kinase.
    Circulation, 2001, Aug-07, Volume: 104, Issue:6

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Blood Flow Velocity; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinases; Cardiovascular Agents; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Dogs; Enzyme Inhibitors; Flavonoids; Hemodynamics; Imidazoles; Indoles; Isoquinolines; Maleimides; Milrinone; Mitogen-Activated Protein Kinases; Myocardial Infarction; p38 Mitogen-Activated Protein Kinases; Phosphodiesterase Inhibitors; Protein Kinase C; Pyridines; Pyridones; Sulfonamides; Ventricular Fibrillation

2001
Angiotensin II promotes the phosphorylation of cyclic AMP-responsive element binding protein (CREB) at Ser133 through an ERK1/2-dependent mechanism.
    Journal of neurochemistry, 2001, Volume: 79, Issue:6

    Topics: Adrenal Medulla; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzylamines; Butadienes; Cattle; Cells, Cultured; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Isoquinolines; Losartan; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Phosphoserine; Protein Processing, Post-Translational; Proto-Oncogene Proteins pp60(c-src); Pyridines; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Ribosomal Protein S6 Kinases; src-Family Kinases; Sulfonamides

2001
Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1).
    The EMBO journal, 2003, Mar-17, Volume: 22, Issue:6

    Topics: Animals; Butadienes; Cell Line; Cell Nucleus; Enzyme Inhibitors; Escherichia coli; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Isoquinolines; L Cells; Mice; Mice, Mutant Strains; Mitogen-Activated Protein Kinases; Models, Biological; Mutation; NF-kappa B; Nitriles; Phosphorylation; Protein Subunits; Pyridines; Recombinant Proteins; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Sulfonamides; Transcriptional Activation; Tumor Necrosis Factor-alpha

2003
The phosphatidylinositol 3-kinase inhibitor LY294002 binds the estrogen receptor and inhibits 17beta-estradiol-induced transcriptional activity of an estrogen sensitive reporter gene.
    Molecular and cellular endocrinology, 2003, Feb-28, Volume: 200, Issue:1-2

    Topics: Animals; Binding Sites; Binding, Competitive; Cells, Cultured; Chromones; Enzyme Inhibitors; Estradiol; Female; Gene Expression Regulation; Genes, Reporter; Genetic Vectors; HeLa Cells; Humans; Imidazoles; Isoquinolines; L Cells; Mice; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Plasmids; Pyridines; Receptors, Estrogen; Sulfonamides; Tamoxifen; Transcription, Genetic

2003
Urocortin-related peptides increase interleukin-6 output via cyclic adenosine 5'-monophosphate-dependent pathways in A7r5 aortic smooth muscle cells.
    Endocrinology, 2003, Volume: 144, Issue:6

    Topics: Animals; Aorta; Cells, Cultured; Corticotropin-Releasing Hormone; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Imidazoles; Imines; Indoles; Interleukin-6; Isoquinolines; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Protein Kinase C; Pyridines; Rats; Sulfonamides; Urocortins

2003
Adrenomedullin increases AP-1 expression in rat mesangial cells via activation of protein kinase-A and p38 MAPK.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2003, Volume: 13, Issue:6

    Topics: Adrenomedullin; Animals; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation; Glomerular Mesangium; Imidazoles; Isoquinolines; Kidney; Male; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Peptides; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Pyridines; Rats; Rats, Sprague-Dawley; Sulfonamides; Transcription Factor AP-1

2003
Possible involvement of p38 MAP kinase in prostaglandin E1-induced ALP activity in osteoblast-like cells.
    Prostaglandins, leukotrienes, and essential fatty acids, 2004, Volume: 70, Issue:5

    Topics: Adenylyl Cyclases; Alkaline Phosphatase; Alprostadil; Animals; Bucladesine; Cell Differentiation; Cell Line; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Imidazoles; Isoquinolines; Mice; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Sulfonamides

2004
p38 mitogen-activated protein kinase downregulates endothelial progenitor cells.
    Circulation, 2005, Mar-08, Volume: 111, Issue:9

    Topics: Activating Transcription Factor 2; Adult; Aged; Amino Acid Sequence; Animals; Apoptosis; Cell Count; Cell Differentiation; Cell Division; Cells, Cultured; Comorbidity; Coronary Disease; Cyclic AMP Response Element-Binding Protein; Female; Glucose; Hindlimb; Humans; Imidazoles; Ischemia; Isoquinolines; Male; Mice; Mice, Nude; Middle Aged; Molecular Sequence Data; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Pyridines; Ribosomal Protein S6 Kinases, 90-kDa; Risk Factors; Signal Transduction; Stem Cell Transplantation; Stem Cells; Sulfonamides; Transcription Factors; Transplantation, Heterologous; Tumor Necrosis Factor-alpha

2005
Hypotonic shock mediation by p38 MAPK, JNK, PKC, FAK, OSR1 and SPAK in osmosensing chloride secreting cells of killifish opercular epithelium.
    The Journal of experimental biology, 2005, Volume: 208, Issue:Pt 6

    Topics: Alkaloids; Animals; Benzophenanthridines; Blotting, Western; Chlorides; Cyclic AMP-Dependent Protein Kinases; Electrophoresis, Polyacrylamide Gel; Electrophysiology; Epithelium; Focal Adhesion Protein-Tyrosine Kinases; Fundulidae; Imidazoles; Immunohistochemistry; Ion Channels; Isoquinolines; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Nova Scotia; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Phenanthridines; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyridines; Saline Solution, Hypertonic; Sulfonamides; Tamoxifen; Water-Electrolyte Balance

2005
Characterization of cAMP-dependent proteolysis of GATA-6.
    Biochemical and biophysical research communications, 2005, Jul-15, Volume: 332, Issue:4

    Topics: Animals; Base Sequence; Benzylamines; Binding Sites; Bucladesine; Carbazoles; Cell Nucleus; CHO Cells; Cricetinae; Cyclic AMP; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; GATA6 Transcription Factor; Humans; Imidazoles; Indole Alkaloids; Isoquinolines; MAP Kinase Kinase Kinase 1; MAP Kinase Signaling System; Molecular Sequence Data; Mutation; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plasmids; Prostaglandin D2; Proteasome Endopeptidase Complex; Protein Binding; Pyridines; src-Family Kinases; Sulfonamides; Transcription Factors

2005
Cyclooxygenase-2 induction by bradykinin in aortic vascular smooth muscle cells.
    American journal of physiology. Heart and circulatory physiology, 2006, Volume: 290, Issue:1

    Topics: Adenylyl Cyclase Inhibitors; Animals; Aorta; Bradykinin; Bradykinin B2 Receptor Antagonists; Butadienes; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 2; Dideoxyadenosine; Enzyme Induction; Imidazoles; Immunohistochemistry; Isoquinolines; Male; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Bradykinin B2; Sulfonamides

2006
Globular adiponectin decreases leptin-induced tumor necrosis factor-alpha expression by murine macrophages: involvement of cAMP-PKA and MAPK pathways.
    Cellular immunology, 2005, Volume: 238, Issue:1

    Topics: Adiponectin; Animals; Butadienes; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Drug Interactions; Enzyme Activation; Flavonoids; Imidazoles; Isoquinolines; Leptin; Macrophages, Peritoneal; Male; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 3; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Sulfonamides; Tumor Necrosis Factor-alpha

2005
Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways.
    The Journal of endocrinology, 2006, Volume: 188, Issue:3

    Topics: Adenylyl Cyclases; Androstadienes; Animals; Animals, Newborn; Cell Line; Cell Proliferation; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyclin D1; Enzyme Activation; Flavonoids; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Human Growth Hormone; Imidazoles; Insulin-Secreting Cells; Isoquinolines; Liraglutide; Mitogen-Activated Protein Kinase Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Rats; Signal Transduction; Stimulation, Chemical; Sulfonamides; Transcription, Genetic; Transduction, Genetic; Wortmannin

2006
Adiponectin stimulates proliferation and cytokine secretion in colonic epithelial cells.
    Regulatory peptides, 2006, May-15, Volume: 134, Issue:2-3

    Topics: Adiponectin; Cell Proliferation; Chemokine CCL2; Cytokines; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; HT29 Cells; Humans; Imidazoles; Indoles; Interleukin-1; Interleukin-8; Intestinal Mucosa; Isoquinolines; Maleimides; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Sulfonamides; Sulfones

2006
ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-kappaB transactivation during oxidative stress in skeletal myoblasts.
    Cellular signalling, 2006, Volume: 18, Issue:12

    Topics: Animals; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Enzyme Activation; Flavonoids; Hydrogen Peroxide; I-kappa B Proteins; Imidazoles; Immunoblotting; Isoquinolines; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Myoblasts, Skeletal; NF-kappa B; NF-KappaB Inhibitor alpha; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Ribosomal Protein S6 Kinases, 90-kDa; Serine; src-Family Kinases; Sulfonamides

2006
PGE2 inhibits apoptosis in human adenocarcinoma Caco-2 cell line through Ras-PI3K association and cAMP-dependent kinase A activation.
    American journal of physiology. Gastrointestinal and liver physiology, 2007, Volume: 293, Issue:4

    Topics: Apoptosis; Caco-2 Cells; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Humans; Imidazoles; Isoquinolines; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyridines; ras Proteins; Sulfonamides

2007
Involvement of regulatory elements on corticotropin-releasing factor gene promoter in hypothalamic 4B cells.
    Journal of endocrinological investigation, 2008, Volume: 31, Issue:12

    Topics: Anthracenes; Cell Line; Chromones; Colforsin; Corticotropin-Releasing Hormone; Dexamethasone; Flavonoids; Genes, Reporter; Humans; Hypothalamus; Imidazoles; Isoquinolines; Morpholines; Promoter Regions, Genetic; Protein Kinase Inhibitors; Pyridines; Regulatory Elements, Transcriptional; Sequence Deletion; Sulfonamides; Transfection

2008
The ceramide-1-phosphate analogue PCERA-1 modulates tumour necrosis factor-alpha and interleukin-10 production in macrophages via the cAMP-PKA-CREB pathway in a GTP-dependent manner.
    Immunology, 2010, Volume: 129, Issue:3

    Topics: Adenylyl Cyclases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bucladesine; Calcium Signaling; Cell Line; Cell Membrane; Ceramides; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Enzyme Inhibitors; Genes, Reporter; Guanosine Triphosphate; Imidazoles; Indoles; Interleukin-10; Isoquinolines; Lipopolysaccharides; Macrophages; Mice; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Response Elements; Ribosomal Protein S6 Kinases, 90-kDa; Rolipram; Signal Transduction; Sulfonamides; Transfection; Tumor Necrosis Factor-alpha

2010
β1-Adrenoceptor autoantibodies from DCM patients enhance the proliferation of T lymphocytes through the β1-AR/cAMP/PKA and p38 MAPK pathways.
    PloS one, 2012, Volume: 7, Issue:12

    Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Agonists; Aged; Animals; Autoantibodies; Cardiomyopathy, Dilated; Cell Proliferation; Cyclic AMP-Dependent Protein Kinases; Female; Humans; Imidazoles; Interferon-gamma; Isoproterenol; Isoquinolines; Male; Metoprolol; Middle Aged; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-1; Signal Transduction; Sulfonamides; T-Lymphocytes

2012
Enhancement of the p38 MAPK and PKA signaling pathways is associated with the pro-melanogenic activity of Interleukin 33 in primary melanocytes.
    Journal of dermatological science, 2014, Volume: 73, Issue:2

    Topics: Adolescent; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Cytokines; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Interleukin-1; Interleukin-33; Interleukins; Isoquinolines; Male; Melanocytes; Monophenol Monooxygenase; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pigmentation; Pyridines; Recombinant Proteins; Signal Transduction; Sulfonamides; Young Adult

2014
Lactoferrin stimulates osteoblast differentiation through PKA and p38 pathways independent of lactoferrin's receptor LRP1.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2014, Volume: 29, Issue:5

    Topics: Animals; Cell Differentiation; Cell Line; Cyclic AMP-Dependent Protein Kinases; Imidazoles; Isoquinolines; Lactoferrin; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 3; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Receptors, Cell Surface; Sulfonamides

2014
Involvement of β-adrenoceptors in the differentiation of human induced pluripotent stem cells into mesodermal progenitor cells.
    European journal of pharmacology, 2014, Oct-05, Volume: 740

    Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-2 Receptor Antagonists; Adrenergic beta-Agonists; Atenolol; Cell Differentiation; Cell Line; Cyclic AMP-Dependent Protein Kinases; Humans; Imidazoles; Induced Pluripotent Stem Cells; Isoproterenol; Isoquinolines; p38 Mitogen-Activated Protein Kinases; Propanolamines; Protein Kinase Inhibitors; Pyridines; Receptors, Adrenergic, beta; Sulfonamides; Vascular Endothelial Growth Factor Receptor-2

2014
Differentiation of human umbilical cord Wharton's jelly-derived mesenchymal stem cells into endometrial cells.
    Stem cell research & therapy, 2017, Nov-02, Volume: 8, Issue:1

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; CD13 Antigens; Cell Differentiation; Cell Proliferation; Cyclic AMP-Dependent Protein Kinases; Endometrium; Epithelial Cells; Estradiol; Female; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Insulin-Like Growth Factor Binding Protein 1; Intercellular Signaling Peptides and Proteins; Isoquinolines; Keratins; Mesenchymal Stem Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Primary Cell Culture; Prolactin; Pyridines; Signal Transduction; Stromal Cells; Sulfonamides; Tetraspanin 29; Umbilical Cord; Vimentin; Wharton Jelly

2017
Zinc alpha2 glycoprotein promotes browning in adipocytes.
    Biochemical and biophysical research communications, 2018, 02-05, Volume: 496, Issue:2

    Topics: 3T3-L1 Cells; Adipocytes, Brown; Adipokines; Animals; Apoptosis Regulatory Proteins; Carbon-Carbon Ligases; Carnitine O-Palmitoyltransferase; Carrier Proteins; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Gene Expression Regulation; Glycoproteins; Imidazoles; Isoquinolines; Lipase; Lipid Metabolism; Mice; NF-E2-Related Factor 2; Nuclear Respiratory Factor 1; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Pyridines; Signal Transduction; Sulfonamides; Transcription Factors; Uncoupling Protein 1

2018