sb 203580 has been researched along with genistein in 49 studies
| Studies (sb 203580) | Trials (sb 203580) | Recent Studies (post-2010) (sb 203580) | Studies (genistein) | Trials (genistein) | Recent Studies (post-2010) (genistein) |
|---|---|---|---|---|---|
| 3,489 | 4 | 1,137 | 7,423 | 204 | 2,311 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (16.33) | 18.2507 |
| 2000's | 36 (73.47) | 29.6817 |
| 2010's | 3 (6.12) | 24.3611 |
| 2020's | 2 (4.08) | 2.80 |
| Authors | Studies |
|---|---|
| Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H | 1 |
| Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M | 1 |
| Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ | 1 |
| Bharate, SB; Raghuvanshi, R | 1 |
| Caballero, E; García-Cárceles, J; Gil, C; Martínez, A | 1 |
| Das, DK; Maulik, N; Price, BD; Sato, M | 1 |
| Jaakkola, P; Jalkanen, M; Kauppi, T; Kontusaari, S; Määtä, A | 1 |
| Kapus, A; Rizoli, SB; Rotstein, OD | 1 |
| Creanor, J; Flatman, PW | 1 |
| Daniels, I; Fletcher, J; Haynes, AP | 1 |
| Sharp, PA; Tang, H | 1 |
| Carvalho, AP; Cruz, MT; Duarte, CB; Gonçalo, M; Lopes, MC | 1 |
| Kato, K; Kawamura, H; Kozawa, O; Matsui, N; Matsuno, H; Niwa, M; Otsuka, T; Uematsu, T | 1 |
| Bansal, R; Baron, W; de Vries, H; Hoekstra, D; Metz, B | 1 |
| Heads, RJ; Marber, MS; Mockridge, JW | 1 |
| Dickenson, JM; Germack, R | 1 |
| Altura, BM; Altura, BT; Wang, J; Yang, ZW; Zheng, T | 1 |
| Chang, CI; Kuo, L; Liao, JC; Zoghi, B | 1 |
| Davis, HW; Zhao, Y | 1 |
| Kitamura, M; Konta, T; Lucio-Cazana, J; Moreno-Manzano, V; Nakayama, K | 1 |
| Aihara, Y; Arai, M; Kanai, H; Kanda, T; Kurabayashi, M; Nagai, R; Sekiguchi, K; Tanaka, T; Yokoyama, T | 1 |
| Botelho, F; Ceponis, PJ; McKay, DM; Richards, CD | 1 |
| Bosmann, M; Chang, JH; Hellmuth, M; Huwiler, A; Mühl, H; Ninic, R; Nold, M; Paulukat, J; Pfeilschifter, J | 1 |
| Hirota, K; Semenza, GL | 1 |
| Fish, EN; Fujita, S; Grumbach, IM; Lekmine, F; Majchrzak, B; Mayer, IA; Platanias, LC; Ravandi, F; Uddin, S; Verma, A | 1 |
| Chu, AJ; Seto, A; Walton, MA; Wang, ZG | 1 |
| Avkiran, M; Hearse, DJ; Snabaitis, AK | 1 |
| Caramona, MM; Carvalho, AP; Lopes, MC; Mendes, AF | 1 |
| Bompadre, MB; Coso, OA; Fernández, GC; Gómez, S; Isturiz, MA; Palermo, MS; Rosa, FA; Rubel, C | 1 |
| Ho, YS; Lee, HM; Lin, CH; Thum, WY; Wu, CH | 1 |
| Araki, Y; Nitto, T; Sendo, F; Takeda, Y | 1 |
| Berti, E; Burlando, B; Magnelli, V; Panfoli, I; Viarengo, A | 1 |
| Dai, J; Remick, DG; Wang, X; Zeng, X | 1 |
| Chain, BM; Cho, JY; Katz, DR | 1 |
| Hori, M; Karaki, H; Ozaki, H; Tasaki, K; Wakabayashi, I | 1 |
| Cerbán, FM; Coso, OA; Stempin, CC; Tanos, TB | 1 |
| Dransfield, I; McMeekin, SR; Ruchaud-Sparagano, MH; Walker, TR | 1 |
| Hirano, K; Kanaide, H; Maeda, Y; Nishimura, J; Sasaki, T | 1 |
| Ingelfinger, JR; Moini, B; Zhang, SL | 1 |
| Ariga, H; Matsumoto, K; Minamitani, T; Orba, Y; Sato, M; Sawa, H | 1 |
| Arcand, M; du Souich, P; Fradette, C; Kourylko, O | 1 |
| Checa, M; Edwards, DR; García-Alvarez, J; Nuttall, RK; Pardo, A; Ramirez, R; Sampieri, CL; Selman, M | 1 |
| Frias, MA; Gerber-Wicht, C; Lang, U; Rebsamen, MC | 1 |
| Liao, QC; Qin, YF; Xiao, ZS; Zhou, HH | 1 |
| Carraro-Lacroix, LR; Girardi, AC; Malnic, G | 1 |
| Di Rosa, M; Li Volti, G; Malaguarnera, L; Marsullo, AR; Zambito, AM | 1 |
| Jeon, YT; Kim, SH; Kim, YB; Lee, SC; Song, YS | 1 |
| Bilitewski, U; Cui, S; Wienhoefer, N | 1 |
| Choi, S; Jiao, HY; Jun, JY; Kim, MW; Kim, SW; Lee, MJ; Na, J; Park, CG; Park, IK; Shin, DH; So, I | 1 |
1 review(s) available for sb 203580 and genistein
| Article | Year |
|---|---|
Kinase Inhibitors as Underexplored Antiviral Agents.
Topics: Animals; Antiviral Agents; Drug Repositioning; Humans; Protein Kinase Inhibitors; Virus Diseases; Viruses | 2022 |
48 other study(ies) available for sb 203580 and genistein
| Article | Year |
|---|---|
Identifying off-target effects and hidden phenotypes of drugs in human cells.
Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship | 2006 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2007 |
Identification of potent Yes1 kinase inhibitors using a library screening approach.
Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship | 2013 |
Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections.
Topics: Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Drug Approval; Drug Repositioning; High-Throughput Screening Assays; Humans; Protein Kinase Inhibitors; SARS-CoV-2; United States; United States Food and Drug Administration; Virus Diseases | 2022 |
An essential role of NFkappaB in tyrosine kinase signaling of p38 MAP kinase regulation of myocardial adaptation to ischemia.
Topics: Adaptation, Physiological; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Creatine Kinase; Genistein; Heart; Imidazoles; In Vitro Techniques; Malondialdehyde; Mitogen-Activated Protein Kinases; Myocardial Ischemia; Myocardial Reperfusion Injury; NF-kappa B; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Peptides; Protein-Tyrosine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction | 1998 |
Wound reepithelialization activates a growth factor-responsive enhancer in migrating keratinocytes.
Topics: Animals; Anisomycin; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Cell Movement; Enhancer Elements, Genetic; Enzyme Inhibitors; Epithelium; Fibroblast Growth Factors; Flavonoids; Gene Expression Regulation; Genistein; Imidazoles; In Vitro Techniques; Keratinocytes; Membrane Glycoproteins; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Proteoglycans; Pyridines; Receptors, Growth Factor; Skin Physiological Phenomena; Suramin; Syndecan-1; Syndecans; Transcriptional Activation; Wound Healing | 1998 |
Cell volume-dependent regulation of L-selectin shedding in neutrophils. A role for p38 mitogen-activated protein kinase.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Size; Cytosol; Enzyme Inhibitors; Genistein; Humans; Hydrogen-Ion Concentration; Hydroxamic Acids; Hypertonic Solutions; Imidazoles; In Vitro Techniques; L-Selectin; Macrophage-1 Antigen; Metalloendopeptidases; Mitogen-Activated Protein Kinases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphotyrosine; Protease Inhibitors; Pyridines | 1999 |
Stimulation of Na+-K+-2Cl- cotransport by arsenite in ferret erythrocytes.
Topics: Animals; Arsenites; Bumetanide; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Chlorides; Edetic Acid; Enzyme Inhibitors; Erythrocytes; Ferrets; Flavonoids; Genistein; Homeostasis; Imidazoles; In Vitro Techniques; Models, Biological; Potassium; Pyridines; Rubidium; Rubidium Radioisotopes; Sodium; Sodium-Potassium-Chloride Symporters; Staurosporine | 1999 |
Role of p38 in the priming of human neutrophils by peritoneal dialysis effluent.
Topics: Antibodies; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; In Vitro Techniques; Kidney Failure, Chronic; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NADPH Oxidases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Peritoneal Dialysis; Phospholipases A; Phosphoric Diester Hydrolases; Phosphorylation; Protein-Tyrosine Kinases; Pyridines; Superoxides | 1999 |
Transcriptional regulation of the murine 3' IgH enhancer by OCT-2.
Topics: 3' Untranslated Regions; Alleles; Animals; B-Lymphocytes; Cyclic AMP-Dependent Protein Kinases; DNA; DNA-Binding Proteins; Enhancer Elements, Genetic; Enzyme Inhibitors; Gene Expression Regulation; Genistein; Imidazoles; Immunoglobulin Heavy Chains; Isoquinolines; Lipopolysaccharides; Lymphocyte Activation; Mice; Mice, Knockout; Mutagenesis, Site-Directed; Octamer Transcription Factor-2; Phosphorylation; Protein Binding; Protein Kinase C; Protein Processing, Post-Translational; Protein Structure, Tertiary; Pyridines; Recombinant Fusion Proteins; Staurosporine; Structure-Activity Relationship; Sulfonamides; Trans-Activators; Transcription Factors; Transcriptional Activation; Transfection | 1999 |
Involvement of JAK2 and MAPK on type II nitric oxide synthase expression in skin-derived dendritic cells.
Topics: Animals; Cell Nucleus; Cells, Cultured; Dendritic Cells; Enzyme Inhibitors; Fetus; Flavonoids; Fluorescent Antibody Technique; Genistein; Granulocyte-Macrophage Colony-Stimulating Factor; Imidazoles; Interleukin-1; Janus Kinase 2; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyridines; Skin; Tumor Necrosis Factor-alpha; Tyrphostins | 1999 |
Endothelin-1 stimulates heat shock protein 27 induction in osteoblasts: involvement of p38 MAP kinase.
Topics: Animals; Antihypertensive Agents; Blotting, Northern; Carcinogens; Cells, Cultured; Endothelin-1; Enzyme Inhibitors; Estrenes; Flavonoids; Gene Expression Regulation, Enzymologic; Genistein; Heat-Shock Proteins; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Naphthalenes; Oligopeptides; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Peptides, Cyclic; Phorbol Esters; Phosphodiesterase Inhibitors; Phosphorylation; Piperidines; Propranolol; Protein Kinase C; Pyridines; Pyrrolidinones; RNA, Messenger; Skull; Staurosporine | 1999 |
PDGF and FGF-2 signaling in oligodendrocyte progenitor cells: regulation of proliferation and differentiation by multiple intracellular signaling pathways.
Topics: Animals; Cell Differentiation; Cell Division; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Estrenes; Fibroblast Growth Factor 2; Flavonoids; Genistein; Imidazoles; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Myristoylated Alanine-Rich C Kinase Substrate; Nerve Tissue Proteins; Oligodendroglia; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Protein Processing, Post-Translational; Proteins; Pyridines; Pyrrolidinones; Rats; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Stem Cells | 2000 |
Activation of Akt during simulated ischemia/reperfusion in cardiac myocytes.
Topics: Androstadienes; Animals; Animals, Newborn; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Genistein; Imidazoles; Kinetics; Models, Cardiovascular; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Pyridines; Rats; Retroviridae Proteins, Oncogenic; Wortmannin | 2000 |
Activation of protein kinase B by the A(1)-adenosine receptor in DDT(1)MF-2 cells.
Topics: Adenosine; Androstadienes; Animals; Calcium; Cell Line; Chromones; Cricetinae; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Imidazoles; Indoles; Insulin; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyridines; Receptors, Purinergic P1; Virulence Factors, Bordetella; Wortmannin; Xanthines | 2000 |
Low [Mg(2+)](o) induces contraction of cerebral arteries: roles of tyrosine and mitogen-activated protein kinases.
Topics: Animals; Basilar Artery; Butadienes; Dogs; Enzyme Inhibitors; Flavonoids; Genistein; Imidazoles; In Vitro Techniques; Magnesium; Magnesium Deficiency; Male; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth, Vascular; Nitriles; Phosphopeptides; Protein-Tyrosine Kinases; Pyridines | 2000 |
The involvement of tyrosine kinases, cyclic AMP/protein kinase A, and p38 mitogen-activated protein kinase in IL-13-mediated arginase I induction in macrophages: its implications in IL-13-inhibited nitric oxide production.
Topics: Animals; Arginase; Benzoquinones; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dexamethasone; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Genistein; Imidazoles; Interleukin-13; Intracellular Fluid; Lactams, Macrocyclic; Macrophages; Mice; Mitogen-Activated Protein Kinases; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Pyridines; Quinones; Rifabutin; RNA, Messenger | 2000 |
Endotoxin causes phosphorylation of MARCKS in pulmonary vascular endothelial cells.
Topics: Animals; Cattle; Cell Membrane; Cells, Cultured; Cytosol; Endothelium, Vascular; Enzyme Inhibitors; Genistein; Gram-Negative Bacterial Infections; Imidazoles; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinases; Myosin Light Chains; Myristoylated Alanine-Rich C Kinase Substrate; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Transport; Protein-Tyrosine Kinases; Proteins; Pulmonary Artery; Pyridines; Respiratory Distress Syndrome; Tetradecanoylphorbol Acetate; Thrombin | 2000 |
Enhancement of TNF-alpha-induced apoptosis by immobilized arginine-glycine-aspartate: involvement of a tyrosine kinase-dependent, MAP kinase-independent mechanism.
Topics: Animals; Apoptosis; Benzoquinones; Cells, Cultured; Curcumin; Enzyme Inhibitors; Flavonoids; Genes, Dominant; Genistein; Glomerular Mesangium; Hydrogen Peroxide; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; MAP Kinase Signaling System; Microscopy, Phase-Contrast; Mitogen-Activated Protein Kinases; Mutation; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Pyridines; Quinones; Rats; Rifabutin; Time Factors; Transcription Factor AP-1; Transfection; Tumor Necrosis Factor-alpha | 2000 |
Induction of VEGF gene transcription by IL-1 beta is mediated through stress-activated MAP kinases and Sp1 sites in cardiac myocytes.
Topics: Animals; Animals, Newborn; Cells, Cultured; Dactinomycin; Dinoprost; Endothelial Growth Factors; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Genistein; Heart; Imidazoles; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Lymphokines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Myocardium; Naphthalenes; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Rats; Rats, Wistar; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; RNA, Messenger; Sp1 Transcription Factor; Stress, Physiological; Transcription, Genetic; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Superantigen immune stimulation activates epithelial STAT-1 and PI 3-K: PI 3-K regulation of permeability.
Topics: Antineoplastic Agents; Cell Membrane Permeability; Cells, Cultured; Chromones; Colon; DNA-Binding Proteins; Electric Impedance; Enterotoxins; Enzyme Activation; Enzyme Inhibitors; Genistein; Humans; Imidazoles; Interferon-gamma; Intestinal Mucosa; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; STAT1 Transcription Factor; Superantigens; Trans-Activators | 2000 |
Nitric oxide augments release of chemokines from monocytic U937 cells: modulation by anti-inflammatory pathways.
Topics: Chemokine CCL4; Chemokines; Cyclic AMP; Dexamethasone; Enzyme Inhibitors; Genistein; Humans; Imidazoles; Inflammation; Interleukin-8; Macrophage Inflammatory Proteins; Mitogen-Activated Protein Kinases; Monocytes; Nitric Oxide; Nitric Oxide Donors; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Pyridines; Signal Transduction; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Triazenes; U937 Cells | 2000 |
Rac1 activity is required for the activation of hypoxia-inducible factor 1.
Topics: Animals; Binding Sites; Cell Hypoxia; Cell Line; Chromones; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genetic Vectors; Genistein; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Mammals; Morpholines; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Pyridines; rac1 GTP-Binding Protein; Recombinant Fusion Proteins; Signal Transduction; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured | 2001 |
The p38 MAPK pathway mediates the growth inhibitory effects of interferon-alpha in BCR-ABL-expressing cells.
Topics: Androstadienes; Cell Division; Cell Line; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Genistein; Humans; Imidazoles; Immunoblotting; Interferon-alpha; Intracellular Signaling Peptides and Proteins; K562 Cells; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Tyrosine; Wortmannin | 2001 |
Involvement of MAPK activation in bacterial endotoxin-inducible tissue factor upregulation in human monocytic THP-1 cells.
Topics: Cell Line; Endotoxins; Enzyme Activation; Enzyme Inhibitors; Escherichia coli; Genistein; Humans; Imidazoles; Isoenzymes; Lipopolysaccharides; Mitogen-Activated Protein Kinases; Monocytes; Phosphorylation; Pyridines; Thromboplastin; Tyrosine; Up-Regulation | 2001 |
Regulation of sarcolemmal Na(+)/H(+) exchange by hydrogen peroxide in adult rat ventricular myocytes.
Topics: Animals; Cells, Cultured; DNA-Binding Proteins; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Genistein; Hydrogen Peroxide; Imidazoles; Immunoblotting; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinases; Myocardium; p38 Mitogen-Activated Protein Kinases; Plant Proteins; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Quinazolines; Rats; Rats, Wistar; Sarcolemma; Signal Transduction; Sodium-Hydrogen Exchangers; src-Family Kinases; Tyrphostins | 2002 |
Role of mitogen-activated protein kinases and tyrosine kinases on IL-1-Induced NF-kappaB activation and iNOS expression in bovine articular chondrocytes.
Topics: Animals; Cartilage, Articular; Cattle; Chondrocytes; Enzyme Inhibitors; Genistein; Humans; Imidazoles; Interleukin-1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Pyridines; Signal Transduction; Transcription Factor AP-1; Tyrphostins | 2002 |
Soluble fibrinogen modulates neutrophil functionality through the activation of an extracellular signal-regulated kinase-dependent pathway.
Topics: Apoptosis; Benzoquinones; Cell Degranulation; Cytoplasmic Granules; Enzyme Activation; Enzyme Inhibitors; Fibrinogen; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Humans; Imidazoles; Kinetics; Lactams, Macrocyclic; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Neutrophils; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Pyridines; Quinones; Rifabutin; Solubility | 2002 |
Involvement of p38 mitogen-activated protein kinase in PLL-AGE-induced cyclooxgenase-2 expression.
Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Dose-Response Relationship, Drug; Enzyme Activation; Genistein; Glycation End Products, Advanced; Imidazoles; Isoenzymes; Lipopolysaccharides; Mitogen-Activated Protein Kinases; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Polylysine; Polymyxin B; Prostaglandin-Endoperoxide Synthases; Pyridines; Reactive Oxygen Species | 2002 |
Pharmacological analysis for mechanisms of GPI-80 release from tumour necrosis factor-alpha-stimulated human neutrophils.
Topics: Amidohydrolases; Antioxidants; CD18 Antigens; Cell Adhesion; Cell Adhesion Molecules; Cytochalasin B; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; GPI-Linked Proteins; Humans; Hydrolases; Imidazoles; In Vitro Techniques; Neutrophil Activation; Neutrophils; Pyridines; Structure-Activity Relationship; Time Factors; Tumor Necrosis Factor-alpha | 2002 |
Ligand-independent tyrosine kinase signalling in RTH 149 trout hepatoma cells: comparison among heavy metals and pro-oxidants.
Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Copper; DNA-Binding Proteins; Dose-Response Relationship, Drug; Genistein; Hydrogen Peroxide; Imidazoles; Ligands; Mercury; Metals, Heavy; Milk Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oxidants; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Pyridines; Receptor Protein-Tyrosine Kinases; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; STAT5 Transcription Factor; Trans-Activators; Tyrosine | 2003 |
Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes.
Topics: Antioxidants; Cells, Cultured; Chemokine CCL2; Chromans; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genistein; Homocysteine; Humans; Imidazoles; Indoles; Interleukin-8; Monocytes; Naphthalenes; Onium Compounds; Pyridines; Pyrrolidines; Reactive Oxygen Species; RNA, Messenger; Sulfonamides; Thiazoles; Thiazolidinediones; Thiocarbamates; Time Factors; Troglitazone; Tyrphostins | 2003 |
Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation.
Topics: Acetophenones; Adenosine Triphosphate; Benzopyrans; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; CD18 Antigens; Cell Aggregation; Cycloheximide; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; Indoles; Integrin beta1; Isoenzymes; Maleimides; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Phosphotransferases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Staurosporine; Temperature; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; U937 Cells | 2003 |
Difference in signal transduction mechanisms involved in 5-hydroxytryptamine- and U46619-induced vasoconstrictions.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta; Calcium; Enzyme Inhibitors; Extracellular Fluid; Genistein; Imidazoles; Male; Naphthalenes; Pyridines; Rats; Rats, Wistar; Serotonin; Signal Transduction; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents; Verapamil | 2003 |
Arginase induction promotes Trypanosoma cruzi intracellular replication in Cruzipain-treated J774 cells through the activation of multiple signaling pathways.
Topics: Animals; Arginase; Arginine; Carbazoles; Cell Division; Cyclic AMP-Dependent Protein Kinases; Cysteine Endopeptidases; Enzyme Induction; Genistein; Growth Inhibitors; Imidazoles; Indoles; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Protozoan Proteins; Pyridines; Pyrroles; Signal Transduction; Trypanosoma cruzi | 2004 |
A critical 'threshold' of beta 2-integrin engagement regulates augmentation of cytokine-mediated superoxide anion release.
Topics: Binding Sites; CD18 Antigens; Cell Adhesion; Cytochalasin D; Cytokines; Cytoskeleton; Genistein; Humans; Imidazoles; Indoles; Integrin beta Chains; Magnesium; Maleimides; Microspheres; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nocodazole; Particle Size; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyridines; Pyrimidines; Serum Albumin; src-Family Kinases; Superoxides; Technology, Pharmaceutical; Tissue Adhesions; Tumor Necrosis Factor-alpha | 2004 |
Endothelial dysfunction and altered bradykinin response due to oxidative stress induced by serum deprivation in the bovine cerebral artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Ascorbic Acid; Bradykinin; Cattle; Cerebral Arteries; Chromones; Culture Media; Culture Media, Serum-Free; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Genistein; Imidazoles; In Vitro Techniques; Indoles; Maleimides; Morpholines; Oxidative Stress; Potassium; Protein Kinase Inhibitors; Pyridines; Serum; Superoxide Dismutase; Time Factors; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2004 |
Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor.
Topics: Angiotensin II; Animals; Anthracenes; Blotting, Western; Cells, Cultured; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Flavonoids; Genistein; Imidazoles; Kidney; Losartan; Mice; Microscopy, Fluorescence; Onium Compounds; PAX2 Transcription Factor; Phosphorylation; Plasmids; Pyridines; Receptors, Angiotensin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Transcription Factors; Tyrphostins; Up-Regulation | 2004 |
Induction of matrix metalloproteinase-2 by tenascin-X deficiency is mediated through the c-Jun N-terminal kinase and protein tyrosine kinase phosphorylation pathway.
Topics: Androstadienes; Animals; Animals, Newborn; Anthracenes; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Genistein; Imidazoles; Male; Matrix Metalloproteinase 2; Mice; Mice, Knockout; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-jun; Pyridines; Skin; Tenascin; Wortmannin | 2004 |
Modulation of CYP1A2 and CYP3A6 catalytic activities by serum from rabbits with a turpentine-induced inflammatory reaction and interleukin 6.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Catalysis; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; Hepatocytes; Imidazoles; Immune Sera; Inflammation; Interleukin-6; Male; Mitogen-Activated Protein Kinase 1; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pyridines; Rabbits; Signal Transduction; Turpentine | 2006 |
Tissue inhibitor of metalloproteinase-3 is up-regulated by transforming growth factor-beta1 in vitro and expressed in fibroblastic foci in vivo in idiopathic pulmonary fibrosis.
Topics: Cells, Cultured; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Genistein; Humans; Imidazoles; Interferon-gamma; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; p38 Mitogen-Activated Protein Kinases; Pulmonary Fibrosis; Pyridines; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-3; Transforming Growth Factor beta; Transforming Growth Factor beta1; Up-Regulation | 2006 |
Prostaglandin E2 activates Stat3 in neonatal rat ventricular cardiomyocytes: A role in cardiac hypertrophy.
Topics: Animals; Animals, Newborn; Blotting, Western; Butadienes; Cardiomegaly; Cells, Cultured; Cycloheximide; Dactinomycin; Dinoprostone; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Gene Silencing; Genistein; Imidazoles; Janus Kinases; Myocytes, Cardiac; Nitriles; Phosphorylation; Protein Synthesis Inhibitors; Pyridines; Rats; Rats, Wistar; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; RNA Interference; Signal Transduction; STAT3 Transcription Factor; Stress, Mechanical | 2007 |
Genistein stimulates osteoblastic differentiation via p38 MAPK-Cbfa1 pathway in bone marrow culture.
Topics: Alkaline Phosphatase; Animals; Blotting, Northern; Blotting, Western; Bone Marrow Cells; Calcium; Cell Differentiation; Cells, Cultured; Core Binding Factor Alpha 1 Subunit; Electrophoretic Mobility Shift Assay; Female; Genistein; Imidazoles; Integrin-Binding Sialoprotein; Mice; Osteoblasts; Osteocalcin; Osteopontin; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phytoestrogens; Protein Binding; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Sialoglycoproteins; Signal Transduction; Transcription, Genetic | 2007 |
Long-term regulation of vacuolar H(+)-ATPase by angiotensin II in proximal tubule cells.
Topics: Ammonium Chloride; Androstadienes; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Buffers; Cell Line, Transformed; Cell Membrane; Cycloheximide; Dactinomycin; Epithelial Cells; Gene Expression; Genistein; Hydrogen-Ion Concentration; Imidazoles; Kidney Tubules, Proximal; Losartan; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Subunits; Protein Transport; Protein-Tyrosine Kinases; Pyridines; Rats; Time Factors; Up-Regulation; Vacuolar Proton-Translocating ATPases; Wortmannin | 2009 |
Prolactin induces chitotriosidase expression in human macrophages through PTK, PI3-K, and MAPK pathways.
Topics: Acetophenones; Benzopyrans; Butadienes; Chromones; Gene Expression Regulation, Enzymologic; Genistein; Hexosaminidases; Humans; Imidazoles; Macrophages; MAP Kinase Signaling System; Monocytes; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphorylation; Prolactin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; RNA, Messenger; Tyrphostins | 2009 |
Genistein inhibits cell growth by modulating various mitogen-activated protein kinases and AKT in cervical cancer cells.
Topics: Androstadienes; Anthracenes; Anticarcinogenic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Flavonoids; Genistein; HeLa Cells; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Uterine Cervical Neoplasms; Wortmannin | 2009 |
Genistein induces morphology change and G2/M cell cycle arrest by inducing p38 MAPK activation in macrophages.
Topics: Actins; Animals; Candida albicans; Cell Line; Cell Shape; Cytoskeleton; Enzyme Activation; Enzyme Inhibitors; G2 Phase Cell Cycle Checkpoints; Genistein; Imidazoles; Macrophages; Mice; p38 Mitogen-Activated Protein Kinases; Phagocytosis; Pyridines | 2014 |
Regulatory Roles of Endogenous Mitogen-Activated Protein Kinases and Tyrosine Kinases in the Pacemaker Activity of Colonic Interstitial Cells of Cajal.
Topics: Animals; Anthracenes; Benzophenanthridines; Cells, Cultured; Chromones; Colon; Flavonoids; Genistein; Imidazoles; Interstitial Cells of Cajal; Intestine, Small; Membrane Potentials; Mice; Mitogen-Activated Protein Kinases; Morpholines; Naphthalenes; Protein-Tyrosine Kinases; Pyridines; Rifabutin | 2015 |