Page last updated: 2024-09-05

sb 203580 and genistein

sb 203580 has been researched along with genistein in 49 studies

Compound Research Comparison

Studies
(sb 203580)
Trials
(sb 203580)
Recent Studies (post-2010)
(sb 203580)
Studies
(genistein)
Trials
(genistein)
Recent Studies (post-2010) (genistein)
3,48941,1377,4232042,311

Protein Interaction Comparison

ProteinTaxonomysb 203580 (IC50)genistein (IC50)
Chain A, Estrogen receptor 1 (alpha)Homo sapiens (human)0.009
Maltase-glucoamylase, intestinalHomo sapiens (human)2.61
Steroid hormone receptor ERR2Homo sapiens (human)0.395
Tyrosine-protein kinase ABL1Homo sapiens (human)5.5
Epidermal growth factor receptorHomo sapiens (human)1.2
TransthyretinHomo sapiens (human)7.8
Estrogen receptorHomo sapiens (human)1.3477
Steroid hormone receptor ERR1Homo sapiens (human)0.01
Polyunsaturated fatty acid lipoxygenase ALOX15Oryctolagus cuniculus (rabbit)9.033
17-beta-hydroxysteroid dehydrogenase type 1Homo sapiens (human)2.21
Protein kinase C alpha typeHomo sapiens (human)1
cAMP-dependent protein kinase catalytic subunit alphaHomo sapiens (human)1
Amine oxidase [flavin-containing] AHomo sapiens (human)4.184
Thromboxane-A synthase Homo sapiens (human)7.72
Amine oxidase [flavin-containing] BHomo sapiens (human)3.9333
Dipeptidyl peptidase 4Homo sapiens (human)0.48
Proteasome subunit beta type-5Homo sapiens (human)9.26
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)0.395
Tyrosine-protein kinase CSKHomo sapiens (human)1
Dual specificity mitogen-activated protein kinase kinase 4Homo sapiens (human)0.4
Xanthine dehydrogenase/oxidaseBos taurus (cattle)1.73
Aldehyde oxidaseHomo sapiens (human)0.34
Integrase Human immunodeficiency virus 11.1
Estrogen receptor betaHomo sapiens (human)0.3706
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)Plasmodium falciparum (malaria parasite P. falciparum)7
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)3.8905
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)7.85
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)9.1201

Research

Studies (49)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (16.33)18.2507
2000's36 (73.47)29.6817
2010's3 (6.12)24.3611
2020's2 (4.08)2.80

Authors

AuthorsStudies
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H1
Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Bharate, SB; Raghuvanshi, R1
Caballero, E; García-Cárceles, J; Gil, C; Martínez, A1
Das, DK; Maulik, N; Price, BD; Sato, M1
Jaakkola, P; Jalkanen, M; Kauppi, T; Kontusaari, S; Määtä, A1
Kapus, A; Rizoli, SB; Rotstein, OD1
Creanor, J; Flatman, PW1
Daniels, I; Fletcher, J; Haynes, AP1
Sharp, PA; Tang, H1
Carvalho, AP; Cruz, MT; Duarte, CB; Gonçalo, M; Lopes, MC1
Kato, K; Kawamura, H; Kozawa, O; Matsui, N; Matsuno, H; Niwa, M; Otsuka, T; Uematsu, T1
Bansal, R; Baron, W; de Vries, H; Hoekstra, D; Metz, B1
Heads, RJ; Marber, MS; Mockridge, JW1
Dickenson, JM; Germack, R1
Altura, BM; Altura, BT; Wang, J; Yang, ZW; Zheng, T1
Chang, CI; Kuo, L; Liao, JC; Zoghi, B1
Davis, HW; Zhao, Y1
Kitamura, M; Konta, T; Lucio-Cazana, J; Moreno-Manzano, V; Nakayama, K1
Aihara, Y; Arai, M; Kanai, H; Kanda, T; Kurabayashi, M; Nagai, R; Sekiguchi, K; Tanaka, T; Yokoyama, T1
Botelho, F; Ceponis, PJ; McKay, DM; Richards, CD1
Bosmann, M; Chang, JH; Hellmuth, M; Huwiler, A; Mühl, H; Ninic, R; Nold, M; Paulukat, J; Pfeilschifter, J1
Hirota, K; Semenza, GL1
Fish, EN; Fujita, S; Grumbach, IM; Lekmine, F; Majchrzak, B; Mayer, IA; Platanias, LC; Ravandi, F; Uddin, S; Verma, A1
Chu, AJ; Seto, A; Walton, MA; Wang, ZG1
Avkiran, M; Hearse, DJ; Snabaitis, AK1
Caramona, MM; Carvalho, AP; Lopes, MC; Mendes, AF1
Bompadre, MB; Coso, OA; Fernández, GC; Gómez, S; Isturiz, MA; Palermo, MS; Rosa, FA; Rubel, C1
Ho, YS; Lee, HM; Lin, CH; Thum, WY; Wu, CH1
Araki, Y; Nitto, T; Sendo, F; Takeda, Y1
Berti, E; Burlando, B; Magnelli, V; Panfoli, I; Viarengo, A1
Dai, J; Remick, DG; Wang, X; Zeng, X1
Chain, BM; Cho, JY; Katz, DR1
Hori, M; Karaki, H; Ozaki, H; Tasaki, K; Wakabayashi, I1
Cerbán, FM; Coso, OA; Stempin, CC; Tanos, TB1
Dransfield, I; McMeekin, SR; Ruchaud-Sparagano, MH; Walker, TR1
Hirano, K; Kanaide, H; Maeda, Y; Nishimura, J; Sasaki, T1
Ingelfinger, JR; Moini, B; Zhang, SL1
Ariga, H; Matsumoto, K; Minamitani, T; Orba, Y; Sato, M; Sawa, H1
Arcand, M; du Souich, P; Fradette, C; Kourylko, O1
Checa, M; Edwards, DR; García-Alvarez, J; Nuttall, RK; Pardo, A; Ramirez, R; Sampieri, CL; Selman, M1
Frias, MA; Gerber-Wicht, C; Lang, U; Rebsamen, MC1
Liao, QC; Qin, YF; Xiao, ZS; Zhou, HH1
Carraro-Lacroix, LR; Girardi, AC; Malnic, G1
Di Rosa, M; Li Volti, G; Malaguarnera, L; Marsullo, AR; Zambito, AM1
Jeon, YT; Kim, SH; Kim, YB; Lee, SC; Song, YS1
Bilitewski, U; Cui, S; Wienhoefer, N1
Choi, S; Jiao, HY; Jun, JY; Kim, MW; Kim, SW; Lee, MJ; Na, J; Park, CG; Park, IK; Shin, DH; So, I1

Reviews

1 review(s) available for sb 203580 and genistein

ArticleYear
Kinase Inhibitors as Underexplored Antiviral Agents.
    Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2

    Topics: Animals; Antiviral Agents; Drug Repositioning; Humans; Protein Kinase Inhibitors; Virus Diseases; Viruses

2022

Other Studies

48 other study(ies) available for sb 203580 and genistein

ArticleYear
Identifying off-target effects and hidden phenotypes of drugs in human cells.
    Nature chemical biology, 2006, Volume: 2, Issue:6

    Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

2006
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-18, Volume: 104, Issue:51

    Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

2007
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections.
    Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2

    Topics: Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Drug Approval; Drug Repositioning; High-Throughput Screening Assays; Humans; Protein Kinase Inhibitors; SARS-CoV-2; United States; United States Food and Drug Administration; Virus Diseases

2022
An essential role of NFkappaB in tyrosine kinase signaling of p38 MAP kinase regulation of myocardial adaptation to ischemia.
    FEBS letters, 1998, Jun-16, Volume: 429, Issue:3

    Topics: Adaptation, Physiological; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Creatine Kinase; Genistein; Heart; Imidazoles; In Vitro Techniques; Malondialdehyde; Mitogen-Activated Protein Kinases; Myocardial Ischemia; Myocardial Reperfusion Injury; NF-kappa B; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Peptides; Protein-Tyrosine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction

1998
Wound reepithelialization activates a growth factor-responsive enhancer in migrating keratinocytes.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1998, Volume: 12, Issue:11

    Topics: Animals; Anisomycin; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Cell Movement; Enhancer Elements, Genetic; Enzyme Inhibitors; Epithelium; Fibroblast Growth Factors; Flavonoids; Gene Expression Regulation; Genistein; Imidazoles; In Vitro Techniques; Keratinocytes; Membrane Glycoproteins; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Proteoglycans; Pyridines; Receptors, Growth Factor; Skin Physiological Phenomena; Suramin; Syndecan-1; Syndecans; Transcriptional Activation; Wound Healing

1998
Cell volume-dependent regulation of L-selectin shedding in neutrophils. A role for p38 mitogen-activated protein kinase.
    The Journal of biological chemistry, 1999, Jul-30, Volume: 274, Issue:31

    Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cell Size; Cytosol; Enzyme Inhibitors; Genistein; Humans; Hydrogen-Ion Concentration; Hydroxamic Acids; Hypertonic Solutions; Imidazoles; In Vitro Techniques; L-Selectin; Macrophage-1 Antigen; Metalloendopeptidases; Mitogen-Activated Protein Kinases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphotyrosine; Protease Inhibitors; Pyridines

1999
Stimulation of Na+-K+-2Cl- cotransport by arsenite in ferret erythrocytes.
    The Journal of physiology, 1999, Aug-15, Volume: 519 Pt 1

    Topics: Animals; Arsenites; Bumetanide; Calcimycin; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Chlorides; Edetic Acid; Enzyme Inhibitors; Erythrocytes; Ferrets; Flavonoids; Genistein; Homeostasis; Imidazoles; In Vitro Techniques; Models, Biological; Potassium; Pyridines; Rubidium; Rubidium Radioisotopes; Sodium; Sodium-Potassium-Chloride Symporters; Staurosporine

1999
Role of p38 in the priming of human neutrophils by peritoneal dialysis effluent.
    Clinical and diagnostic laboratory immunology, 1999, Volume: 6, Issue:6

    Topics: Antibodies; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; In Vitro Techniques; Kidney Failure, Chronic; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NADPH Oxidases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Peritoneal Dialysis; Phospholipases A; Phosphoric Diester Hydrolases; Phosphorylation; Protein-Tyrosine Kinases; Pyridines; Superoxides

1999
Transcriptional regulation of the murine 3' IgH enhancer by OCT-2.
    Immunity, 1999, Volume: 11, Issue:5

    Topics: 3' Untranslated Regions; Alleles; Animals; B-Lymphocytes; Cyclic AMP-Dependent Protein Kinases; DNA; DNA-Binding Proteins; Enhancer Elements, Genetic; Enzyme Inhibitors; Gene Expression Regulation; Genistein; Imidazoles; Immunoglobulin Heavy Chains; Isoquinolines; Lipopolysaccharides; Lymphocyte Activation; Mice; Mice, Knockout; Mutagenesis, Site-Directed; Octamer Transcription Factor-2; Phosphorylation; Protein Binding; Protein Kinase C; Protein Processing, Post-Translational; Protein Structure, Tertiary; Pyridines; Recombinant Fusion Proteins; Staurosporine; Structure-Activity Relationship; Sulfonamides; Trans-Activators; Transcription Factors; Transcriptional Activation; Transfection

1999
Involvement of JAK2 and MAPK on type II nitric oxide synthase expression in skin-derived dendritic cells.
    The American journal of physiology, 1999, Volume: 277, Issue:6

    Topics: Animals; Cell Nucleus; Cells, Cultured; Dendritic Cells; Enzyme Inhibitors; Fetus; Flavonoids; Fluorescent Antibody Technique; Genistein; Granulocyte-Macrophage Colony-Stimulating Factor; Imidazoles; Interleukin-1; Janus Kinase 2; Lipopolysaccharides; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyridines; Skin; Tumor Necrosis Factor-alpha; Tyrphostins

1999
Endothelin-1 stimulates heat shock protein 27 induction in osteoblasts: involvement of p38 MAP kinase.
    The American journal of physiology, 1999, Volume: 277, Issue:6

    Topics: Animals; Antihypertensive Agents; Blotting, Northern; Carcinogens; Cells, Cultured; Endothelin-1; Enzyme Inhibitors; Estrenes; Flavonoids; Gene Expression Regulation, Enzymologic; Genistein; Heat-Shock Proteins; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Naphthalenes; Oligopeptides; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Peptides, Cyclic; Phorbol Esters; Phosphodiesterase Inhibitors; Phosphorylation; Piperidines; Propranolol; Protein Kinase C; Pyridines; Pyrrolidinones; RNA, Messenger; Skull; Staurosporine

1999
PDGF and FGF-2 signaling in oligodendrocyte progenitor cells: regulation of proliferation and differentiation by multiple intracellular signaling pathways.
    Molecular and cellular neurosciences, 2000, Volume: 15, Issue:3

    Topics: Animals; Cell Differentiation; Cell Division; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Estrenes; Fibroblast Growth Factor 2; Flavonoids; Genistein; Imidazoles; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Myristoylated Alanine-Rich C Kinase Substrate; Nerve Tissue Proteins; Oligodendroglia; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Protein Processing, Post-Translational; Proteins; Pyridines; Pyrrolidinones; Rats; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Stem Cells

2000
Activation of Akt during simulated ischemia/reperfusion in cardiac myocytes.
    Biochemical and biophysical research communications, 2000, Apr-21, Volume: 270, Issue:3

    Topics: Androstadienes; Animals; Animals, Newborn; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Genistein; Imidazoles; Kinetics; Models, Cardiovascular; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein-Tyrosine Kinases; Pyridines; Rats; Retroviridae Proteins, Oncogenic; Wortmannin

2000
Activation of protein kinase B by the A(1)-adenosine receptor in DDT(1)MF-2 cells.
    British journal of pharmacology, 2000, Volume: 130, Issue:4

    Topics: Adenosine; Androstadienes; Animals; Calcium; Cell Line; Chromones; Cricetinae; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Imidazoles; Indoles; Insulin; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyridines; Receptors, Purinergic P1; Virulence Factors, Bordetella; Wortmannin; Xanthines

2000
Low [Mg(2+)](o) induces contraction of cerebral arteries: roles of tyrosine and mitogen-activated protein kinases.
    American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:1

    Topics: Animals; Basilar Artery; Butadienes; Dogs; Enzyme Inhibitors; Flavonoids; Genistein; Imidazoles; In Vitro Techniques; Magnesium; Magnesium Deficiency; Male; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth, Vascular; Nitriles; Phosphopeptides; Protein-Tyrosine Kinases; Pyridines

2000
The involvement of tyrosine kinases, cyclic AMP/protein kinase A, and p38 mitogen-activated protein kinase in IL-13-mediated arginase I induction in macrophages: its implications in IL-13-inhibited nitric oxide production.
    Journal of immunology (Baltimore, Md. : 1950), 2000, Aug-15, Volume: 165, Issue:4

    Topics: Animals; Arginase; Benzoquinones; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dexamethasone; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Genistein; Imidazoles; Interleukin-13; Intracellular Fluid; Lactams, Macrocyclic; Macrophages; Mice; Mitogen-Activated Protein Kinases; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Pyridines; Quinones; Rifabutin; RNA, Messenger

2000
Endotoxin causes phosphorylation of MARCKS in pulmonary vascular endothelial cells.
    Journal of cellular biochemistry, 2000, Sep-07, Volume: 79, Issue:3

    Topics: Animals; Cattle; Cell Membrane; Cells, Cultured; Cytosol; Endothelium, Vascular; Enzyme Inhibitors; Genistein; Gram-Negative Bacterial Infections; Imidazoles; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinases; Myosin Light Chains; Myristoylated Alanine-Rich C Kinase Substrate; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Transport; Protein-Tyrosine Kinases; Proteins; Pulmonary Artery; Pyridines; Respiratory Distress Syndrome; Tetradecanoylphorbol Acetate; Thrombin

2000
Enhancement of TNF-alpha-induced apoptosis by immobilized arginine-glycine-aspartate: involvement of a tyrosine kinase-dependent, MAP kinase-independent mechanism.
    Biochemical and biophysical research communications, 2000, Oct-22, Volume: 277, Issue:2

    Topics: Animals; Apoptosis; Benzoquinones; Cells, Cultured; Curcumin; Enzyme Inhibitors; Flavonoids; Genes, Dominant; Genistein; Glomerular Mesangium; Hydrogen Peroxide; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; MAP Kinase Signaling System; Microscopy, Phase-Contrast; Mitogen-Activated Protein Kinases; Mutation; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Pyridines; Quinones; Rats; Rifabutin; Time Factors; Transcription Factor AP-1; Transfection; Tumor Necrosis Factor-alpha

2000
Induction of VEGF gene transcription by IL-1 beta is mediated through stress-activated MAP kinases and Sp1 sites in cardiac myocytes.
    Journal of molecular and cellular cardiology, 2000, Volume: 32, Issue:11

    Topics: Animals; Animals, Newborn; Cells, Cultured; Dactinomycin; Dinoprost; Endothelial Growth Factors; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Genistein; Heart; Imidazoles; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Lymphokines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Myocardium; Naphthalenes; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Rats; Rats, Wistar; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; RNA, Messenger; Sp1 Transcription Factor; Stress, Physiological; Transcription, Genetic; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2000
Superantigen immune stimulation activates epithelial STAT-1 and PI 3-K: PI 3-K regulation of permeability.
    American journal of physiology. Gastrointestinal and liver physiology, 2000, Volume: 279, Issue:5

    Topics: Antineoplastic Agents; Cell Membrane Permeability; Cells, Cultured; Chromones; Colon; DNA-Binding Proteins; Electric Impedance; Enterotoxins; Enzyme Activation; Enzyme Inhibitors; Genistein; Humans; Imidazoles; Interferon-gamma; Intestinal Mucosa; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; STAT1 Transcription Factor; Superantigens; Trans-Activators

2000
Nitric oxide augments release of chemokines from monocytic U937 cells: modulation by anti-inflammatory pathways.
    Free radical biology & medicine, 2000, Nov-15, Volume: 29, Issue:10

    Topics: Chemokine CCL4; Chemokines; Cyclic AMP; Dexamethasone; Enzyme Inhibitors; Genistein; Humans; Imidazoles; Inflammation; Interleukin-8; Macrophage Inflammatory Proteins; Mitogen-Activated Protein Kinases; Monocytes; Nitric Oxide; Nitric Oxide Donors; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Pyridines; Signal Transduction; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Triazenes; U937 Cells

2000
Rac1 activity is required for the activation of hypoxia-inducible factor 1.
    The Journal of biological chemistry, 2001, Jun-15, Volume: 276, Issue:24

    Topics: Animals; Binding Sites; Cell Hypoxia; Cell Line; Chromones; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genetic Vectors; Genistein; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Mammals; Morpholines; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Pyridines; rac1 GTP-Binding Protein; Recombinant Fusion Proteins; Signal Transduction; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured

2001
The p38 MAPK pathway mediates the growth inhibitory effects of interferon-alpha in BCR-ABL-expressing cells.
    The Journal of biological chemistry, 2001, Jul-27, Volume: 276, Issue:30

    Topics: Androstadienes; Cell Division; Cell Line; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Genistein; Humans; Imidazoles; Immunoblotting; Interferon-alpha; Intracellular Signaling Peptides and Proteins; K562 Cells; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Tyrosine; Wortmannin

2001
Involvement of MAPK activation in bacterial endotoxin-inducible tissue factor upregulation in human monocytic THP-1 cells.
    The Journal of surgical research, 2001, Volume: 101, Issue:1

    Topics: Cell Line; Endotoxins; Enzyme Activation; Enzyme Inhibitors; Escherichia coli; Genistein; Humans; Imidazoles; Isoenzymes; Lipopolysaccharides; Mitogen-Activated Protein Kinases; Monocytes; Phosphorylation; Pyridines; Thromboplastin; Tyrosine; Up-Regulation

2001
Regulation of sarcolemmal Na(+)/H(+) exchange by hydrogen peroxide in adult rat ventricular myocytes.
    Cardiovascular research, 2002, Feb-01, Volume: 53, Issue:2

    Topics: Animals; Cells, Cultured; DNA-Binding Proteins; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Genistein; Hydrogen Peroxide; Imidazoles; Immunoblotting; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinases; Myocardium; p38 Mitogen-Activated Protein Kinases; Plant Proteins; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Quinazolines; Rats; Rats, Wistar; Sarcolemma; Signal Transduction; Sodium-Hydrogen Exchangers; src-Family Kinases; Tyrphostins

2002
Role of mitogen-activated protein kinases and tyrosine kinases on IL-1-Induced NF-kappaB activation and iNOS expression in bovine articular chondrocytes.
    Nitric oxide : biology and chemistry, 2002, Volume: 6, Issue:1

    Topics: Animals; Cartilage, Articular; Cattle; Chondrocytes; Enzyme Inhibitors; Genistein; Humans; Imidazoles; Interleukin-1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Pyridines; Signal Transduction; Transcription Factor AP-1; Tyrphostins

2002
Soluble fibrinogen modulates neutrophil functionality through the activation of an extracellular signal-regulated kinase-dependent pathway.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Apr-01, Volume: 168, Issue:7

    Topics: Apoptosis; Benzoquinones; Cell Degranulation; Cytoplasmic Granules; Enzyme Activation; Enzyme Inhibitors; Fibrinogen; Flavonoids; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Genistein; Humans; Imidazoles; Kinetics; Lactams, Macrocyclic; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Neutrophils; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Pyridines; Quinones; Rifabutin; Solubility

2002
Involvement of p38 mitogen-activated protein kinase in PLL-AGE-induced cyclooxgenase-2 expression.
    European journal of pharmacology, 2002, Mar-08, Volume: 438, Issue:3

    Topics: Acetylcysteine; Animals; Buthionine Sulfoximine; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Dose-Response Relationship, Drug; Enzyme Activation; Genistein; Glycation End Products, Advanced; Imidazoles; Isoenzymes; Lipopolysaccharides; Mitogen-Activated Protein Kinases; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Polylysine; Polymyxin B; Prostaglandin-Endoperoxide Synthases; Pyridines; Reactive Oxygen Species

2002
Pharmacological analysis for mechanisms of GPI-80 release from tumour necrosis factor-alpha-stimulated human neutrophils.
    British journal of pharmacology, 2002, Volume: 137, Issue:3

    Topics: Amidohydrolases; Antioxidants; CD18 Antigens; Cell Adhesion; Cell Adhesion Molecules; Cytochalasin B; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; GPI-Linked Proteins; Humans; Hydrolases; Imidazoles; In Vitro Techniques; Neutrophil Activation; Neutrophils; Pyridines; Structure-Activity Relationship; Time Factors; Tumor Necrosis Factor-alpha

2002
Ligand-independent tyrosine kinase signalling in RTH 149 trout hepatoma cells: comparison among heavy metals and pro-oxidants.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2003, Volume: 13, Issue:3

    Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Copper; DNA-Binding Proteins; Dose-Response Relationship, Drug; Genistein; Hydrogen Peroxide; Imidazoles; Ligands; Mercury; Metals, Heavy; Milk Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oxidants; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Pyridines; Receptor Protein-Tyrosine Kinases; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; STAT5 Transcription Factor; Trans-Activators; Tyrosine

2003
Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes.
    Circulation research, 2003, Aug-22, Volume: 93, Issue:4

    Topics: Antioxidants; Cells, Cultured; Chemokine CCL2; Chromans; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genistein; Homocysteine; Humans; Imidazoles; Indoles; Interleukin-8; Monocytes; Naphthalenes; Onium Compounds; Pyridines; Pyrrolidines; Reactive Oxygen Species; RNA, Messenger; Sulfonamides; Thiazoles; Thiazolidinediones; Thiocarbamates; Time Factors; Troglitazone; Tyrphostins

2003
Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation.
    British journal of pharmacology, 2003, Volume: 140, Issue:2

    Topics: Acetophenones; Adenosine Triphosphate; Benzopyrans; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; CD18 Antigens; Cell Aggregation; Cycloheximide; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; Indoles; Integrin beta1; Isoenzymes; Maleimides; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Phosphotransferases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Staurosporine; Temperature; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; U937 Cells

2003
Difference in signal transduction mechanisms involved in 5-hydroxytryptamine- and U46619-induced vasoconstrictions.
    Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 2003, Volume: 39, Issue:5

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta; Calcium; Enzyme Inhibitors; Extracellular Fluid; Genistein; Imidazoles; Male; Naphthalenes; Pyridines; Rats; Rats, Wistar; Serotonin; Signal Transduction; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents; Verapamil

2003
Arginase induction promotes Trypanosoma cruzi intracellular replication in Cruzipain-treated J774 cells through the activation of multiple signaling pathways.
    European journal of immunology, 2004, Volume: 34, Issue:1

    Topics: Animals; Arginase; Arginine; Carbazoles; Cell Division; Cyclic AMP-Dependent Protein Kinases; Cysteine Endopeptidases; Enzyme Induction; Genistein; Growth Inhibitors; Imidazoles; Indoles; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein-Tyrosine Kinases; Protozoan Proteins; Pyridines; Pyrroles; Signal Transduction; Trypanosoma cruzi

2004
A critical 'threshold' of beta 2-integrin engagement regulates augmentation of cytokine-mediated superoxide anion release.
    British journal of pharmacology, 2004, Volume: 141, Issue:7

    Topics: Binding Sites; CD18 Antigens; Cell Adhesion; Cytochalasin D; Cytokines; Cytoskeleton; Genistein; Humans; Imidazoles; Indoles; Integrin beta Chains; Magnesium; Maleimides; Microspheres; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nocodazole; Particle Size; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyridines; Pyrimidines; Serum Albumin; src-Family Kinases; Superoxides; Technology, Pharmaceutical; Tissue Adhesions; Tumor Necrosis Factor-alpha

2004
Endothelial dysfunction and altered bradykinin response due to oxidative stress induced by serum deprivation in the bovine cerebral artery.
    European journal of pharmacology, 2004, Apr-26, Volume: 491, Issue:1

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Ascorbic Acid; Bradykinin; Cattle; Cerebral Arteries; Chromones; Culture Media; Culture Media, Serum-Free; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Genistein; Imidazoles; In Vitro Techniques; Indoles; Maleimides; Morpholines; Oxidative Stress; Potassium; Protein Kinase Inhibitors; Pyridines; Serum; Superoxide Dismutase; Time Factors; Vasoconstriction; Vasoconstrictor Agents; Vasodilation

2004
Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor.
    Journal of the American Society of Nephrology : JASN, 2004, Volume: 15, Issue:6

    Topics: Angiotensin II; Animals; Anthracenes; Blotting, Western; Cells, Cultured; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Flavonoids; Genistein; Imidazoles; Kidney; Losartan; Mice; Microscopy, Fluorescence; Onium Compounds; PAX2 Transcription Factor; Phosphorylation; Plasmids; Pyridines; Receptors, Angiotensin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Transcription Factors; Tyrphostins; Up-Regulation

2004
Induction of matrix metalloproteinase-2 by tenascin-X deficiency is mediated through the c-Jun N-terminal kinase and protein tyrosine kinase phosphorylation pathway.
    Experimental cell research, 2004, Jul-15, Volume: 297, Issue:2

    Topics: Androstadienes; Animals; Animals, Newborn; Anthracenes; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Genistein; Imidazoles; Male; Matrix Metalloproteinase 2; Mice; Mice, Knockout; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-jun; Pyridines; Skin; Tenascin; Wortmannin

2004
Modulation of CYP1A2 and CYP3A6 catalytic activities by serum from rabbits with a turpentine-induced inflammatory reaction and interleukin 6.
    Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:1

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Catalysis; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; Hepatocytes; Imidazoles; Immune Sera; Inflammation; Interleukin-6; Male; Mitogen-Activated Protein Kinase 1; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pyridines; Rabbits; Signal Transduction; Turpentine

2006
Tissue inhibitor of metalloproteinase-3 is up-regulated by transforming growth factor-beta1 in vitro and expressed in fibroblastic foci in vivo in idiopathic pulmonary fibrosis.
    Experimental lung research, 2006, Volume: 32, Issue:5

    Topics: Cells, Cultured; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Genistein; Humans; Imidazoles; Interferon-gamma; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; p38 Mitogen-Activated Protein Kinases; Pulmonary Fibrosis; Pyridines; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-3; Transforming Growth Factor beta; Transforming Growth Factor beta1; Up-Regulation

2006
Prostaglandin E2 activates Stat3 in neonatal rat ventricular cardiomyocytes: A role in cardiac hypertrophy.
    Cardiovascular research, 2007, Jan-01, Volume: 73, Issue:1

    Topics: Animals; Animals, Newborn; Blotting, Western; Butadienes; Cardiomegaly; Cells, Cultured; Cycloheximide; Dactinomycin; Dinoprostone; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Gene Silencing; Genistein; Imidazoles; Janus Kinases; Myocytes, Cardiac; Nitriles; Phosphorylation; Protein Synthesis Inhibitors; Pyridines; Rats; Rats, Wistar; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; RNA Interference; Signal Transduction; STAT3 Transcription Factor; Stress, Mechanical

2007
Genistein stimulates osteoblastic differentiation via p38 MAPK-Cbfa1 pathway in bone marrow culture.
    Acta pharmacologica Sinica, 2007, Volume: 28, Issue:10

    Topics: Alkaline Phosphatase; Animals; Blotting, Northern; Blotting, Western; Bone Marrow Cells; Calcium; Cell Differentiation; Cells, Cultured; Core Binding Factor Alpha 1 Subunit; Electrophoretic Mobility Shift Assay; Female; Genistein; Imidazoles; Integrin-Binding Sialoprotein; Mice; Osteoblasts; Osteocalcin; Osteopontin; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phytoestrogens; Protein Binding; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Sialoglycoproteins; Signal Transduction; Transcription, Genetic

2007
Long-term regulation of vacuolar H(+)-ATPase by angiotensin II in proximal tubule cells.
    Pflugers Archiv : European journal of physiology, 2009, Volume: 458, Issue:5

    Topics: Ammonium Chloride; Androstadienes; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Buffers; Cell Line, Transformed; Cell Membrane; Cycloheximide; Dactinomycin; Epithelial Cells; Gene Expression; Genistein; Hydrogen-Ion Concentration; Imidazoles; Kidney Tubules, Proximal; Losartan; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Subunits; Protein Transport; Protein-Tyrosine Kinases; Pyridines; Rats; Time Factors; Up-Regulation; Vacuolar Proton-Translocating ATPases; Wortmannin

2009
Prolactin induces chitotriosidase expression in human macrophages through PTK, PI3-K, and MAPK pathways.
    Journal of cellular biochemistry, 2009, Aug-01, Volume: 107, Issue:5

    Topics: Acetophenones; Benzopyrans; Butadienes; Chromones; Gene Expression Regulation, Enzymologic; Genistein; Hexosaminidases; Humans; Imidazoles; Macrophages; MAP Kinase Signaling System; Monocytes; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphorylation; Prolactin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; RNA, Messenger; Tyrphostins

2009
Genistein inhibits cell growth by modulating various mitogen-activated protein kinases and AKT in cervical cancer cells.
    Annals of the New York Academy of Sciences, 2009, Volume: 1171

    Topics: Androstadienes; Anthracenes; Anticarcinogenic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Flavonoids; Genistein; HeLa Cells; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Uterine Cervical Neoplasms; Wortmannin

2009
Genistein induces morphology change and G2/M cell cycle arrest by inducing p38 MAPK activation in macrophages.
    International immunopharmacology, 2014, Volume: 18, Issue:1

    Topics: Actins; Animals; Candida albicans; Cell Line; Cell Shape; Cytoskeleton; Enzyme Activation; Enzyme Inhibitors; G2 Phase Cell Cycle Checkpoints; Genistein; Imidazoles; Macrophages; Mice; p38 Mitogen-Activated Protein Kinases; Phagocytosis; Pyridines

2014
Regulatory Roles of Endogenous Mitogen-Activated Protein Kinases and Tyrosine Kinases in the Pacemaker Activity of Colonic Interstitial Cells of Cajal.
    Pharmacology, 2015, Volume: 96, Issue:1-2

    Topics: Animals; Anthracenes; Benzophenanthridines; Cells, Cultured; Chromones; Colon; Flavonoids; Genistein; Imidazoles; Interstitial Cells of Cajal; Intestine, Small; Membrane Potentials; Mice; Mitogen-Activated Protein Kinases; Morpholines; Naphthalenes; Protein-Tyrosine Kinases; Pyridines; Rifabutin

2015