sb 203580 has been researched along with geldanamycin in 4 studies
| Studies (sb 203580) | Trials (sb 203580) | Recent Studies (post-2010) (sb 203580) | Studies (geldanamycin) | Trials (geldanamycin) | Recent Studies (post-2010) (geldanamycin) |
|---|---|---|---|---|---|
| 3,489 | 4 | 1,137 | 96 | 0 | 59 |
| 3,489 | 4 | 1,137 | 1,167 | 1 | 329 |
| Protein | Taxonomy | sb 203580 (IC50) | geldanamycin (IC50) |
|---|---|---|---|
| Lysine-specific demethylase 6B | Homo sapiens (human) | 0.4 | |
| Lysine-specific demethylase 4B | Homo sapiens (human) | 0.7 | |
| Tyrosine-protein kinase ABL1 | Homo sapiens (human) | 3 | |
| ATP-dependent molecular chaperone HSP82 | Saccharomyces cerevisiae S288C | 3.9667 | |
| Cytochrome P450 1A2 | Homo sapiens (human) | 0.014 | |
| Heat shock protein HSP 90-alpha | Homo sapiens (human) | 0.0917 | |
| Heat shock protein HSP 90-beta | Homo sapiens (human) | 0.098 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.014 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 0.014 | |
| Breakpoint cluster region protein | Homo sapiens (human) | 3 | |
| Heat shock protein HSP 90 | Oryctolagus cuniculus (rabbit) | 1.141 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 0.074 | |
| Cytochrome P450 3A5 | Homo sapiens (human) | 0.014 | |
| Cytochrome P450 3A7 | Homo sapiens (human) | 0.014 | |
| Lysine-specific demethylase 5A | Homo sapiens (human) | 0.13 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 0.074 | |
| Endoplasmin | Canis lupus familiaris (dog) | 0.01 | |
| Heat shock protein 75 kDa, mitochondrial | Homo sapiens (human) | 0.661 | |
| Putative heat shock protein HSP 90-alpha A4 | Homo sapiens (human) | 0.14 | |
| Lysine-specific demethylase 4C | Homo sapiens (human) | 0.7 | |
| Cytochrome P450 3A43 | Homo sapiens (human) | 0.014 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H | 1 |
| Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M | 1 |
| Fernández-Renart, M; López-Maderuelo, MD; Moratilla, C; Renart, J | 1 |
| Grant, S; Vrana, JA | 1 |
4 other study(ies) available for sb 203580 and geldanamycin
| Article | Year |
|---|---|
Identifying off-target effects and hidden phenotypes of drugs in human cells.
Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship | 2006 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2007 |
Opposite effects of the Hsp90 inhibitor Geldanamycin: induction of apoptosis in PC12, and differentiation in N2A cells.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Benzoquinones; Cell Differentiation; Enzyme Activation; Enzyme Inhibitors; HSP90 Heat-Shock Proteins; Imidazoles; JNK Mitogen-Activated Protein Kinases; Kinetics; Lactams, Macrocyclic; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Neuroblastoma; PC12 Cells; Phenotype; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins pp60(c-src); Pyridines; Quinones; Rats; Time Factors; Tumor Cells, Cultured | 2001 |
Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade.
Topics: Acetylcysteine; Amanitins; Aminoacetonitrile; Apoptosis; Benzoquinones; Bryostatins; Butadienes; Curcumin; Cysteine Endopeptidases; Dactinomycin; Diterpenes; Drug Synergism; Enzyme Activation; Flavonoids; Humans; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; Lactones; Macrolides; Maleimides; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Nitriles; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Kinase C; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-raf; Pyridines; Quinones; Terpenes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Type C Phospholipases; U937 Cells; Ubiquitins | 2001 |