Compounds > sb 203580
Page last updated: 2024-09-05

sb 203580 and dorsomorphin

sb 203580 has been researched along with dorsomorphin in 10 studies

Compound Research Comparison

Studies
(sb 203580)		Trials
(sb 203580)		Recent Studies (post-2010)
(sb 203580)		Studies
(dorsomorphin)		Trials
(dorsomorphin)		Recent Studies (post-2010) (dorsomorphin)
3,48941,1373631259

Protein Interaction Comparison

ProteinTaxonomysb 203580 (IC50)dorsomorphin (IC50)
Bone morphogenetic protein receptor type-1BHomo sapiens (human)0.351
5'-AMP-activated protein kinase subunit beta-2Homo sapiens (human)0.1355
Tyrosine-protein kinase LckHomo sapiens (human)0.016
Tyrosine-protein kinase YesHomo sapiens (human)0.1128
Platelet-derived growth factor receptor betaHomo sapiens (human)0.1359
Bone morphogenetic protein 4Homo sapiens (human)0.43
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)0.002
Vascular endothelial growth factor receptor 1 Homo sapiens (human)0.011
Ephrin type-A receptor 2Homo sapiens (human)0.011
Vascular endothelial growth factor receptor 2Homo sapiens (human)0.1089
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)0.001
Bone morphogenetic protein receptor type-1AHomo sapiens (human)0.095
TGF-beta receptor type-1Homo sapiens (human)2.6019
Serine/threonine-protein kinase receptor R3Homo sapiens (human)0.1063
TGF-beta receptor type-2Homo sapiens (human)0.1029
Dual specificity protein kinase CLK2Homo sapiens (human)0.1359
5'-AMP-activated protein kinase subunit gamma-1Homo sapiens (human)0.1358
5'-AMP-activated protein kinase catalytic subunit alpha-2Homo sapiens (human)0.1355
Activin receptor type-1Homo sapiens (human)0.1188
5'-AMP-activated protein kinase catalytic subunit alpha-1Homo sapiens (human)0.1355
Bone morphogenetic protein receptor type-2Homo sapiens (human)0.074
Ribosomal protein S6 kinase alpha-1Homo sapiens (human)0.21
MAP kinase-interacting serine/threonine-protein kinase 1Homo sapiens (human)0.011
5'-AMP-activated protein kinase subunit gamma-3Homo sapiens (human)0.1355
5'-AMP-activated protein kinase subunit gamma-2Homo sapiens (human)0.1355
5'-AMP-activated protein kinase subunit beta-1Homo sapiens (human)0.1522

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (10.00)29.6817
2010's8 (80.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N1
Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Plowright, AT; Schade, D1
Caballero, E; García-Cárceles, J; Gil, C; Martínez, A1
Bartrons, R; Gamell, C; Ortuño, MJ; Rodríguez-Carballo, E; Rosa, JL; Susperregui, AR; Ventura, F1
Chenge, J; Cok, A; Louters, LL; Oram, DS; Plaisier, C; Salie, MJ1
Hwang, JK; Jo, K; Lee, SE; Lee, SW1
Bahn, GH; Cho, KS; Choi, CS; Han, SH; Hur, J; Joo, SH; Kim, KC; Kim, P; Ko, HM; Kwon, KJ; Lee, J; Lee, SH; Park, JH; Ryu, JH; Shin, CY1
Gao, P; Wang, Y; Wu, X; Zhang, J; Zhang, L1

Reviews

2 review(s) available for sb 203580 and dorsomorphin

ArticleYear
Medicinal Chemistry Approaches to Heart Regeneration.
    Journal of medicinal chemistry, 2015, Dec-24, Volume: 58, Issue:24

    Topics: Animals; Cell Differentiation; Cell Proliferation; Cellular Reprogramming; Fibroblasts; Humans; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Pluripotent Stem Cells; Regeneration; Signal Transduction; Stem Cells

2015
Kinase Inhibitors as Underexplored Antiviral Agents.
    Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2

    Topics: Animals; Antiviral Agents; Drug Repositioning; Humans; Protein Kinase Inhibitors; Virus Diseases; Viruses

2022

Other Studies

8 other study(ies) available for sb 203580 and dorsomorphin

ArticleYear
The selectivity of protein kinase inhibitors: a further update.
    The Biochemical journal, 2007, Dec-15, Volume: 408, Issue:3

    Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera

2007
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
    The Biochemical journal, 2013, Apr-15, Volume: 451, Issue:2

    Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase

2013
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
Noncanonical BMP signaling regulates cyclooxygenase-2 transcription.
    Molecular endocrinology (Baltimore, Md.), 2011, Volume: 25, Issue:6

    Topics: Animals; Bone Morphogenetic Protein 2; Cell Line; Core Binding Factor Alpha 1 Subunit; Cyclooxygenase 2; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; Mesenchymal Stem Cells; Mice; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun; Pyrazoles; Pyridines; Pyrimidines; Regulatory Elements, Transcriptional; Response Elements; Signal Transduction; Skull; Tissue Culture Techniques; Transcription, Genetic

2011
Berberine acutely activates the glucose transport activity of GLUT1.
    Biochimie, 2011, Volume: 93, Issue:7

    Topics: AMP-Activated Protein Kinases; Animals; Berberine; Biological Transport; Cell Line; Deoxyglucose; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Glucose; Glucose Transporter Type 1; Imidazoles; Kinetics; Mice; p38 Mitogen-Activated Protein Kinases; Pyrazoles; Pyridines; Pyrimidines

2011
Prunus yedoensis Matsum. stimulates glucose uptake in L6 rat skeletal muscle cells by activating AMP-activated protein kinase and phosphatidylinositol 3-kinase/Akt pathways.
    Natural product research, 2012, Volume: 26, Issue:17

    Topics: AMP-Activated Protein Kinases; Animals; Biological Transport; Cell Line; Glucose; Imidazoles; Muscle Fibers, Skeletal; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Prunus; Pyrazoles; Pyridines; Pyrimidines; Rats; Signal Transduction

2012
Glucose deprivation reversibly down-regulates tissue plasminogen activator via proteasomal degradation in rat primary astrocytes.
    Life sciences, 2013, May-20, Volume: 92, Issue:17-19

    Topics: Animals; Astrocytes; Blotting, Western; Chromones; Down-Regulation; Glucose; Imidazoles; Morpholines; Proteasome Endopeptidase Complex; Pyrazoles; Pyridines; Pyrimidines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tissue Plasminogen Activator

2013
Adiponectin attenuates high glucose-induced apoptosis through the AMPK/p38 MAPK signaling pathway in NRK-52E cells.
    PloS one, 2017, Volume: 12, Issue:5

    Topics: Adiponectin; Animals; Apoptosis; Blotting, Western; Cell Line; Flow Cytometry; Glucose; Imidazoles; Kidney Tubules, Proximal; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Phosphorylation; Pyrazoles; Pyridines; Pyrimidines; Rats; Transcriptome

2017