Compounds > sb 203580
Page last updated: 2024-09-05

sb 203580 and dinoprostone

sb 203580 has been researched along with dinoprostone in 63 studies

Compound Research Comparison

Studies
(sb 203580)		Trials
(sb 203580)		Recent Studies (post-2010)
(sb 203580)		Studies
(dinoprostone)		Trials
(dinoprostone)		Recent Studies (post-2010) (dinoprostone)
3,48941,13729,1051,3466,357

Protein Interaction Comparison

ProteinTaxonomysb 203580 (IC50)dinoprostone (IC50)
Prostaglandin E2 receptor EP1 subtypeHomo sapiens (human)0.0155
Prostaglandin E2 receptor EP4 subtypeHomo sapiens (human)0.0031
Prostaglandin E2 receptor EP4 subtypeRattus norvegicus (Norway rat)0.0021
Prostaglandin E2 receptor EP3 subtypeHomo sapiens (human)0.002
Prostaglandin E2 receptor EP2 subtypeHomo sapiens (human)0.0087
Prostacyclin receptorHomo sapiens (human)0.26
Prostaglandin E2 receptor EP2 subtypeRattus norvegicus (Norway rat)0.0052

Research

Studies (63)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (3.17)18.2507
2000's41 (65.08)29.6817
2010's19 (30.16)24.3611
2020's1 (1.59)2.80

Authors

AuthorsStudies
Brook, M; Clark, AR; Dean, JL; Ridley, SH; Saklatvala, J; Sarsfield, SJ1
Abramson, SB; Amin, AR; Attur, MG; Dave, MN; Kumar, S; Lee, JC; Patel, R1
Barnes, PJ; Cambridge, L; Hart, LA; Lindsay, MA; Newton, R; Stevens, DA1
Creminon, C; Hla, T; Huang, CK; Jang, BC; Liu, CH; Sanchez, T; Schaefers, HJ; Trifan, OC1
Lahiri, T; Laporte, JD; Moore, PE; Panettieri, RA; Schwartzman, IN; Shore, SA1
Brune, K; Hinz, B; Pahl, A; Ramer, R1
Cho, CH; Fan, XM; Kung, HF; Lam, SK; Lin, MC; Wang, WP; Wong, BC1
Chan, ED; Cooper, AM; Fouts, D; Josephy, SI; Tse, HM1
Ertl, G; Jacobs, M; Scheuren, N; Schorb, W1
Kato, K; Kozawa, O; Matsuno, H; Niwa, M; Tokuda, H; Uematsu, T1
Fujita, N; Ishida, A; Kitazawa, R; Tsuruo, T1
Akahoshi, M; Arinobu, Y; Harada, M; Inoue, Y; Miyake, K; Nagano, S; Nakashima, H; Niho, Y; Niiro, H; Ogami, E; Otsuka, T; Yamaoka, K1
Itoh, K; Li, X; Murase, Y; Nishihara, T; Suda, K; Suda, T; Takahashi, N; Udagawa, N1
Demetris, AJ; Han, C; Lunz, JG; Michalopoulos, G; Shelhamer, JH; Wu, T1
Berenbaum, F; Bereziat, G; Humbert, L; Thirion, S1
Harada, R; Kobayashi, M; Nakata, H; Taguchi, H; Uemura, Y1
Binder, BR; Bochkov, VN; Huber, J; Leitinger, N1
Lai, WC; Peng, G; Shankavaram, U; Wahl, LM; Zhou, M1
Akahoshi, M; Arinobu, Y; Harada, M; Inoue, Y; Miyake, K; Nagano, S; Nakashima, H; Niiro, H; Ninomiya, I; Ogami, E; Otsuka, T; Shimizu, S1
Cui, Y; Kim, DS; Kim, SK; Kwon, SB; Park, KC; Park, SH; Yoon, JA1
Hosoe, M; Katoh, T; Komurasaki, T; Mikami, Y; Miyahara, T; Nemoto, N; Sakuma, T; Takayama, K; Uchida, S; Watanabe, M1
Catapano, AL; Inoue, H; Norata, GD; Pellegatta, F; Pirillo, A1
Chu, CR; Studer, RK1
Kim, H; Kokkotou, E; LaMont, JT; Moyer, MP; Na, X; Pothoulakis, C; Rhee, SH; Savidge, T1
Bagnato, A; Di Castro, V; Elia, G; Natali, PG; Rosanò, L; Spinella, F1
Gutiérrez-Venegas, G; Kawasaki-Cárdenas, P; Maldonado-Frías, S; Ontiveros-Granados, A1
Jang, JH; Surh, YJ1
Goldring, MB; Jalonen, U; Kankaanranta, H; Lahti, A; Leinonen, S; Moilanen, E; Nieminen, R; Vuolteenaho, K1
Kawakami, T; Olsson, T; Yucel-Lindberg, T1
Clemente, D; Correa, F; Docagne, F; Guaza, C; Mestre, L1
Frias, MA; Gerber-Wicht, C; Lang, U; Rebsamen, MC1
Ashizuka, M; Ito, S; Kubota, Y; Ogata, S; Satoh, S; Shirasuna, K; Takeuchi, H1
Birnbaumer, L; Edwards, RA; Hoang, B; Trinh, A1
Freeman, MR; Kim, J; Misonou, Y; Park, YS; Takahashi, M; Takamiya, R; Taniguchi, N1
Acquaviva, AM; Acquaviva, F; di Palma, A; Di Prisco, AM; Giannouli, M; Iuliano, F; Leone, V; Ricchi, P1
Gho, YS; Lee, EH; Lee, KH; Nam, KN; Yun, SJ1
Aikawa, N; Fukuda, K; Hori, S; Manabe-Kawaguchi, H; Miyatake, S; Watanabe, K1
Chen, Z; Guo, YS; Hellmich, MR; Ko, TC; Townsend, CM; Wen, XD1
Bachelet, M; Bardin, S; Broquet, AH; Gasnereau, I; Jouniaux, AM; Lenoir, C; Masliah, J; Sapin, C; Seksik, P; Thomas, G; Trugnan, G1
Kadonosono, K; Kamei, J; Ohnaka, K; Tanaka, S; Utsunomiya, H; Yamakawa, T1
Gu, R; Jin, Y; Kong, S; Li, W; Wang, L; Wang, WH; Yang, B; Yang, L; Zhai, Y; Zhang, C; Zhang, Y1
Cancedda, FD; Cancedda, R; Ulivi, V1
Hennig, B; Lim, EJ; Toborek, M; Wang, L1
Avni, D; Meijler, MM; Philosoph, A; Zor, T1
Itabe, H; Kato, R; Obama, T; Sakiyama, Y; Suzuki, K; Usui, M; Yamamoto, M1
Chang, HW; Hung, SL; Lai, YL; Lee, YY; Liu, TY; Wu, CY1
Kondo, A; Matsuda, T; Togari, A; Tsunashima, Y1
Deng, X; Li, H; Xiong, H; Yu, L; Zhang, X1
Chen, Z; Doyle, T; Muscoli, C; Obeid, LM; Salvemini, D1
Baumann, S; Böhme, A; Kohajda, T; Lehmann, I; Mögel, I; Simon, JC; von Bergen, M1
Aso, H; Hasegawa, Y; Imaizumi, K; Ito, S; Kondo, M; Mori, A; Morioka, M; Suganuma, N1
Alcolea, S; Alfranca, A; Antón, R; Avilés-Jurado, FX; Camacho, M; León, X; Quer, M; Redondo, JM; Soler, M; Vila, L1
Chang, JZ; Chen, HM; Deng, YT; Kuo, MY; Yang, WH1
Cao, H; Gu, Y; Wu, Y; Yang, Y; Yin, J; Zhang, L; Zhang, Y; Zhao, X; Zhao, Z; Zhou, Y1
Cho, JY; Jeong, D; Kim, KW; Lee, J; Yang, Y; Yi, YS1
Nemoto, E; Shimauchi, H; Suzuki, R1
Cao, J; Fang, L; Fu, J; Ge, D; Li, X; Liu, Z; Ran, J; Ran, Y; Shi, Q; Wang, L; Zhang, H; Zhao, H; Zheng, X; Zhou, Y1
Chen, Q; Song, J; Wei, Y; Xing, D1
Fu, X; Li, Q; Liu, N; Liu, X; Sui, H; Wang, Y; Wu, Q; Ye, N; Yu, NA; Zhou, L; Zhou, N1
Kondo, A; Kozawa, O; Kuroyanagi, G; Matsushima-Nishiwaki, R; Mizutani, J; Otsuka, T; Tokuda, H; Yamamoto, N1
Ashley, AK; Hanneman, WH; Hinds, AI; Legare, ME; Tjalkens, RB1
Fan, C; Li, Y; Song, Q; Wang, P; Yang, M; Yu, SY1
Alhamdoosh, M; Berhan, A; Harris, T; Jaffar, J; Jativa, F; Langenbach, S; Lee, P; Lönnstedt, I; Ng, M; Stewart, AG; Westall, G; Wilson, M; Wilson, N1

Other Studies

63 other study(ies) available for sb 203580 and dinoprostone

ArticleYear
A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase-2 mRNA.
    FEBS letters, 1998, Nov-13, Volume: 439, Issue:1-2

    Topics: Arachidonic Acids; Calcium-Calmodulin-Dependent Protein Kinases; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Enzyme Inhibitors; HeLa Cells; Humans; Imidazoles; Interleukin-1; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Membrane Proteins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines; RNA, Messenger

1998
Regulation of nitric oxide and prostaglandin E2 production by CSAIDS (SB203580) in murine macrophages and bovine chondrocytes stimulated with LPS.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1999, Volume: 48, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Cattle; Cell Line; Chondrocytes; Cyclooxygenase 2; Dinoprostone; Humans; Hydrocortisone; Imidazoles; Isoenzymes; Lipopolysaccharides; Macrophages; Membrane Proteins; Mice; Nitric Oxide; Prostaglandin-Endoperoxide Synthases; Pyridines

1999
The MAP kinase inhibitors, PD098059, UO126 and SB203580, inhibit IL-1beta-dependent PGE(2) release via mechanistically distinct processes.
    British journal of pharmacology, 2000, Volume: 130, Issue:6

    Topics: Arachidonic Acid; Butadienes; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Interleukin-1; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; Time Factors; Tumor Cells, Cultured

2000
Serum withdrawal-induced post-transcriptional stabilization of cyclooxygenase-2 mRNA in MDA-MB-231 mammary carcinoma cells requires the activity of the p38 stress-activated protein kinase.
    The Journal of biological chemistry, 2000, Dec-15, Volume: 275, Issue:50

    Topics: Apoptosis; Blotting, Northern; Blotting, Western; Breast Neoplasms; Bromodeoxyuridine; Cell Cycle; Cell Nucleus; Culture Media, Serum-Free; Cyclooxygenase 2; Dactinomycin; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Genes, Dominant; Humans; Imidazoles; Isoenzymes; Membrane Proteins; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines; RNA Processing, Post-Transcriptional; RNA, Messenger; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured

2000
p38 MAP kinase regulates IL-1 beta responses in cultured airway smooth muscle cells.
    American journal of physiology. Lung cellular and molecular physiology, 2000, Volume: 279, Issue:5

    Topics: Bucladesine; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Humans; Imidazoles; Interleukin-1; Isoenzymes; Isoproterenol; Leupeptins; Membrane Proteins; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; Transcription Factor AP-1

2000
R(+)-methanandamide induces cyclooxygenase-2 expression in human neuroglioma cells via a non-cannabinoid receptor-mediated mechanism.
    Biochemical and biophysical research communications, 2001, Sep-07, Volume: 286, Issue:5

    Topics: Analgesics, Non-Narcotic; Arachidonic Acids; Blotting, Western; Brain Neoplasms; Cannabinoid Receptor Modulators; Cell Line; Central Nervous System; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Dronabinol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glioma; Humans; Imidazoles; Interleukin-1; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Piperidines; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Receptors, Cannabinoid; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella

2001
Interleukin-1beta induces cyclo-oxygenase-2 expression in gastric cancer cells by the p38 and p44/42 mitogen-activated protein kinase signaling pathways.
    Journal of gastroenterology and hepatology, 2001, Volume: 16, Issue:10

    Topics: Adenocarcinoma; Blotting, Western; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Flavonoids; Gene Expression; Humans; Imidazoles; Interleukin-1; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Stomach Neoplasms; Tumor Cells, Cultured; Up-Regulation

2001
Activation of the mitogen-activated protein kinase signaling pathway is instrumental in determining the ability of Mycobacterium avium to grow in murine macrophages.
    Journal of immunology (Baltimore, Md. : 1950), 2002, Jan-15, Volume: 168, Issue:2

    Topics: Animals; Bone Marrow Cells; Cell Division; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Female; Growth Inhibitors; Imidazoles; Indomethacin; Interleukin-10; Interleukin-12; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Macrophages; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mycobacterium avium; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Tumor Necrosis Factor-alpha; Virulence

2002
Cyclooxygenase-2 in myocardium stimulation by angiotensin-II in cultured cardiac fibroblasts and role at acute myocardial infarction.
    Journal of molecular and cellular cardiology, 2002, Volume: 34, Issue:1

    Topics: Angiotensin II; Animals; Blotting, Western; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Egg Proteins; Enzyme Inhibitors; Female; Fibroblasts; Flavonoids; Imidazoles; Immunoblotting; Immunoenzyme Techniques; Immunohistochemistry; Isoenzymes; Lactones; Macrophages; Membrane Glycoproteins; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Myocardium; Necrosis; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyridines; Rats; Rats, Wistar; Receptors, Cell Surface; Sulfones; Time Factors; Vimentin; Zona Pellucida Glycoproteins

2002
Mechanism of prostaglandin E2-stimulated heat shock protein 27 induction in osteoblast-like MC3T3-E1 cells.
    The Journal of endocrinology, 2002, Volume: 172, Issue:2

    Topics: Analysis of Variance; Animals; Butadienes; Calcium; Calcium Channel Blockers; Cell Line; Chelating Agents; Dinoprostone; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Gallic Acid; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Imidazoles; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Molecular Chaperones; Naphthalenes; Neoplasm Proteins; Nitriles; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Pyridines; Pyrrolidinones; Staurosporine; Stimulation, Chemical; Time Factors; Type C Phospholipases

2002
Transforming growth factor-beta induces expression of receptor activator of NF-kappa B ligand in vascular endothelial cells derived from bone.
    The Journal of biological chemistry, 2002, Jul-19, Volume: 277, Issue:29

    Topics: Animals; Bone and Bones; Carbazoles; Carrier Proteins; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Endothelium, Vascular; Enzyme Inhibitors; Humans; Imidazoles; Indoles; Membrane Glycoproteins; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Osteoclasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Pyridines; Pyrroles; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; RNA, Messenger; Transforming Growth Factor beta

2002
Molecular mechanisms of lipopolysaccharide-induced cyclooxygenase-2 expression in human neutrophils: involvement of the mitogen-activated protein kinase pathway and regulation by anti-inflammatory cytokines.
    International immunology, 2002, Volume: 14, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Interleukin-10; Interleukin-4; Isoenzymes; Lipopolysaccharides; Membrane Proteins; Mitogen-Activated Protein Kinases; Neutrophils; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; Signal Transduction

2002
p38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast function.
    Endocrinology, 2002, Volume: 143, Issue:8

    Topics: Animals; Calcitriol; Carrier Proteins; Cell Differentiation; Dinoprostone; Imidazoles; Lipopolysaccharides; Male; Membrane Glycoproteins; Mice; Mitogen-Activated Protein Kinases; Osteoclasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B

2002
Involvement of 85-kd cytosolic phospholipase A(2) and cyclooxygenase-2 in the proliferation of human cholangiocarcinoma cells.
    Hepatology (Baltimore, Md.), 2002, Volume: 36, Issue:2

    Topics: Arachidonic Acids; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Division; Cholangiocarcinoma; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytosol; Dinoprost; Dinoprostone; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Humans; Imidazoles; Interleukin-6; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinases; Nitrobenzenes; Organophosphonates; Phospholipases A; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; Sulfonamides; Tumor Cells, Cultured

2002
Concomitant recruitment of ERK1/2 and p38 MAPK signalling pathway is required for activation of cytoplasmic phospholipase A2 via ATP in articular chondrocytes.
    The Journal of biological chemistry, 2003, Apr-18, Volume: 278, Issue:16

    Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Biological Transport; Blotting, Western; Cartilage, Articular; Chondrocytes; Cytoplasm; Dinoprostone; DNA, Complementary; Dose-Response Relationship, Drug; Electrophoresis; Enzyme Activation; Female; Flavonoids; Genes, Dominant; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Polymerase Chain Reaction; Pyridines; Rabbits; Signal Transduction; Time Factors

2003
Cyclooxygenase-2 inhibitor NS-398 suppresses cell growth and constitutive production of granulocyte-colony stimulating factor and granulocyte macrophage-colony stimulating factor in lung cancer cells.
    Cancer science, 2003, Volume: 94, Issue:2

    Topics: Cell Division; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Progression; Drug Screening Assays, Antitumor; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imidazoles; Interleukin-1; Isoenzymes; Lung Neoplasms; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Proteins; NF-kappa B; Nitrobenzenes; Proline; Prostaglandin-Endoperoxide Synthases; Pyridines; Recombinant Proteins; Sulfonamides; Thiocarbamates; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

2003
The isoprostane 8-iso-PGE2 stimulates endothelial cells to bind monocytes via cyclic AMP- and p38 MAP kinase-dependent signaling pathways.
    Antioxidants & redox signaling, 2003, Volume: 5, Issue:2

    Topics: Arteriosclerosis; Blotting, Western; Cell Adhesion; Cell Communication; Cells, Cultured; Coculture Techniques; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Humans; Imidazoles; Isoprostanes; Leukocytes; Mitogen-Activated Protein Kinases; Monocytes; Neutrophils; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Pyridines; Signal Transduction; Time Factors

2003
Differential regulation of lipopolysaccharide-induced monocyte matrix metalloproteinase (MMP)-1 and MMP-9 by p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases.
    Journal of immunology (Baltimore, Md. : 1950), 2003, Jun-15, Volume: 170, Issue:12

    Topics: Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Isoenzymes; Lipopolysaccharides; Matrix Metalloproteinase 1; Matrix Metalloproteinase 9; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Monocytes; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Pyridines; Transcription Factors

2003
Novel regulatory mechanisms of CD40-induced prostanoid synthesis by IL-4 and IL-10 in human monocytes.
    Journal of immunology (Baltimore, Md. : 1950), 2004, Feb-15, Volume: 172, Issue:4

    Topics: Antibodies, Monoclonal; Carrier Proteins; CD40 Antigens; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Flavonoids; Humans; Imidazoles; Interleukin-10; Interleukin-4; Isoenzymes; Ligands; MAP Kinase Signaling System; Membrane Proteins; Monocytes; NF-kappa B; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Protein Transport; Pyridines; Recombinant Proteins; Repressor Proteins; Sulfonamides

2004
Involvement of ERK AND p38 MAP kinase in AAPH-induced COX-2 expression in HaCaT cells.
    Chemistry and physics of lipids, 2004, Volume: 129, Issue:1

    Topics: Amidines; Catechin; Chromans; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Humans; Imidazoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Keratinocytes; MAP Kinase Kinase 4; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines

2004
Involvement of mitogen-activated protein kinases and protein kinase C in cadmium-induced prostaglandin E2 production in primary mouse osteoblastic cells.
    Toxicology, 2004, Aug-05, Volume: 200, Issue:2-3

    Topics: Animals; Blotting, Western; Cadmium; Dinoprostone; Enzyme Inhibitors; Female; Flavonoids; Imidazoles; Kinetics; Mice; Mitogen-Activated Protein Kinases; Naphthalenes; Osteoblasts; Phospholipases A; Phospholipases A2; Phosphorylation; Pregnancy; Protein Kinase C; Pyridines; Signal Transduction

2004
Native LDL and oxidized LDL modulate cyclooxygenase-2 expression in HUVECs through a p38-MAPK, NF-kappaB, CRE dependent pathway and affect PGE2 synthesis.
    International journal of molecular medicine, 2004, Volume: 14, Issue:3

    Topics: Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Epoprostenol; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Immunoassay; Immunoblotting; Immunohistochemistry; Indomethacin; Lipoproteins, LDL; Membrane Proteins; NF-kappa B; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Thromboxane A2; Time Factors; Umbilical Veins

2004
p38 MAPK and COX2 inhibition modulate human chondrocyte response to TGF-beta.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2005, Volume: 23, Issue:2

    Topics: Cell Proliferation; Chondrocytes; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Humans; Imidazoles; Interleukin-1; p38 Mitogen-Activated Protein Kinases; Proteoglycans; Pyridines; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta

2005
Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK.
    The Journal of biological chemistry, 2005, Jun-03, Volume: 280, Issue:22

    Topics: Animals; Bacterial Toxins; Cell Line; Colon; Cyclic AMP; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enterotoxins; Enzyme Activation; Enzyme Inhibitors; Humans; Ileum; Imidazoles; Immunohistochemistry; Inflammation; Intramolecular Oxidoreductases; Luciferases; Membrane Proteins; Mice; Mice, SCID; Models, Biological; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostaglandin-E Synthases; Prostaglandin-Endoperoxide Synthases; Protein Binding; Pyridines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Signal Transduction; Sulfonamides; Time Factors; Tissue Transplantation; Transfection

2005
Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian cancer cells through multiple signaling pathways: evidence for involvement of transactivation of the epidermal growth factor receptor.
    Journal of cardiovascular pharmacology, 2004, Volume: 44 Suppl 1

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Endothelin A Receptor Antagonists; Endothelin-1; Enzyme Induction; ErbB Receptors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Peptides, Cyclic; Protein Kinase Inhibitors; Pyridines; Quinazolines; Receptor, Endothelin A; Signal Transduction; Transcriptional Activation; Tyrphostins

2004
Role of p38 in nitric oxide synthase and cyclooxygenase expression, and nitric oxide and PGE2 synthesis in human gingival fibroblasts stimulated with lipopolysaccharides.
    Life sciences, 2005, May-20, Volume: 77, Issue:1

    Topics: Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Fibroblasts; Gingiva; Humans; Imidazoles; Lipopolysaccharides; Membrane Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Protein Kinase Inhibitors; Pyridines; RNA, Messenger

2005
Beta-amyloid-induced apoptosis is associated with cyclooxygenase-2 up-regulation via the mitogen-activated protein kinase-NF-kappaB signaling pathway.
    Free radical biology & medicine, 2005, Jun-15, Volume: 38, Issue:12

    Topics: Amyloid beta-Peptides; Animals; Apoptosis; Butadienes; Celecoxib; Cyclooxygenase 2; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Peptide Fragments; Poly(ADP-ribose) Polymerases; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Rats; Sulfonamides; Up-Regulation

2005
Inhibitors of mitogen-activated protein kinases downregulate COX-2 expression in human chondrocytes.
    Mediators of inflammation, 2005, Oct-24, Volume: 2005, Issue:5

    Topics: Anthracenes; Chondrocytes; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Interleukin-1; Mitogen-Activated Protein Kinases; Pyridines; RNA, Messenger; Signal Transduction

2005
Signal pathways involved in the regulation of prostaglandin E synthase-1 in human gingival fibroblasts.
    Cellular signalling, 2006, Volume: 18, Issue:12

    Topics: Arachidonic Acid; Blotting, Western; Cells, Cultured; Child; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression Regulation; Gingiva; Humans; Imidazoles; Indoles; Interleukin-1beta; Intramolecular Oxidoreductases; Maleimides; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Prostaglandin D2; Prostaglandin-E Synthases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha

2006
The synthetic cannabinoid WIN 55,212-2 increases COX-2 expression and PGE2 release in murine brain-derived endothelial cells following Theiler's virus infection.
    Biochemical pharmacology, 2006, Sep-28, Volume: 72, Issue:7

    Topics: Animals; Arachidonic Acids; Benzoxazines; Brain; Cell Nucleus; Cell Survival; Chromones; Cyclooxygenase 2; Dinoprostone; Endocannabinoids; Endothelial Cells; Enzyme Activation; Flavonoids; Fluorescent Antibody Technique; Glycerides; Imidazoles; Mice; Microscopy, Confocal; Mitogen-Activated Protein Kinases; Morpholines; Naphthalenes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Resorcinols; Theilovirus

2006
Prostaglandin E2 activates Stat3 in neonatal rat ventricular cardiomyocytes: A role in cardiac hypertrophy.
    Cardiovascular research, 2007, Jan-01, Volume: 73, Issue:1

    Topics: Animals; Animals, Newborn; Blotting, Western; Butadienes; Cardiomegaly; Cells, Cultured; Cycloheximide; Dactinomycin; Dinoprostone; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Gene Silencing; Genistein; Imidazoles; Janus Kinases; Myocytes, Cardiac; Nitriles; Phosphorylation; Protein Synthesis Inhibitors; Pyridines; Rats; Rats, Wistar; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; RNA Interference; Signal Transduction; STAT3 Transcription Factor; Stress, Mechanical

2007
Ca2+ stimulates COX-2 expression through calcium-sensing receptor in fibroblasts.
    Biochemical and biophysical research communications, 2006, Dec-29, Volume: 351, Issue:4

    Topics: Anthracenes; Bone and Bones; Calcium; Calcium Signaling; Cations, Divalent; Cyclooxygenase 2; Dinoprostone; Estrenes; Fibroblasts; Flavonoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Pyrrolidinones; Receptors, Calcium-Sensing; RNA, Messenger; Type C Phospholipases

2006
Decreased MAPK- and PGE2-dependent IL-11 production in Gialpha2-/- colonic myofibroblasts.
    American journal of physiology. Gastrointestinal and liver physiology, 2007, Volume: 292, Issue:6

    Topics: 16,16-Dimethylprostaglandin E2; Alprostadil; Animals; Cells, Cultured; Colon; Cyclic AMP; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; GTP-Binding Protein alpha Subunit, Gi2; Imidazoles; Interleukin-11; Interleukin-1beta; Intestine, Small; Methyl Ethers; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta

2007
Acrolein induces cyclooxygenase-2 and prostaglandin production in human umbilical vein endothelial cells: roles of p38 MAP kinase.
    Arteriosclerosis, thrombosis, and vascular biology, 2007, Volume: 27, Issue:6

    Topics: Acetophenones; Acrolein; Animals; Atherosclerosis; Benzopyrans; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Induction; Humans; Imidazoles; Lung; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Protein Kinase C-delta; Protein Kinase Inhibitors; Pyridines; RNA, Messenger; Smoking; Time Factors; Transcription, Genetic; Umbilical Veins

2007
PGE2 inhibits apoptosis in human adenocarcinoma Caco-2 cell line through Ras-PI3K association and cAMP-dependent kinase A activation.
    American journal of physiology. Gastrointestinal and liver physiology, 2007, Volume: 293, Issue:4

    Topics: Apoptosis; Caco-2 Cells; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Humans; Imidazoles; Isoquinolines; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyridines; ras Proteins; Sulfonamides

2007
Activation of microglial cells by ceruloplasmin.
    Brain research, 2007, Sep-26, Volume: 1171

    Topics: Animals; Cell Line, Transformed; Cell Survival; Ceruloplasmin; Dinoprostone; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; Lipopolysaccharides; Mice; Microglia; NF-kappaB-Inducing Kinase; Nitric Oxide; Protein Serine-Threonine Kinases; Pyridines; RNA, Messenger; Time Factors; Tumor Necrosis Factor-alpha

2007
Prostaglandin E2 induces hypertrophic changes and suppresses alpha-skeletal actin gene expression in rat cardiomyocytes.
    Journal of cardiovascular pharmacology, 2007, Volume: 50, Issue:5

    Topics: Actins; Animals; Animals, Newborn; Atrial Natriuretic Factor; Blotting, Western; Butadienes; Cell Enlargement; Cell Size; Cells, Cultured; Dinoprostone; Gene Expression; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Naphthalenes; Natriuretic Peptide, Brain; Nitriles; Phenylbutyrates; Phosphorylation; Prostaglandin Antagonists; Protein Biosynthesis; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Reverse Transcriptase Polymerase Chain Reaction

2007
Synergistic regulation of COX-2 expression by bombesin and transforming growth factor-beta.
    Digestive diseases and sciences, 2008, Volume: 53, Issue:8

    Topics: Animals; Bombesin; Cell Line; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Imidazoles; Intestinal Mucosa; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Protein Kinase Inhibitors; Pyridines; Rats; RNA Interference; RNA Stability; RNA, Messenger; Signal Transduction; Time Factors; Transcription, Genetic; Transfection; Transforming Growth Factor beta1

2008
MD-2 controls bacterial lipopolysaccharide hyporesponsiveness in human intestinal epithelial cells.
    Life sciences, 2008, Feb-27, Volume: 82, Issue:9-10

    Topics: Anthracenes; Caco-2 Cells; Cell Line, Tumor; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Flow Cytometry; Gene Expression; HT29 Cells; Humans; Imidazoles; Interleukin-8; Intestines; Lipopolysaccharides; Lymphocyte Antigen 96; Mitogen-Activated Protein Kinases; Monocytes; NF-kappa B; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Toll-Like Receptor 4; Transfection

2008
Cyclooxygenase-2 induction by lysophosphatidylcholine in cultured rat vascular smooth muscle cells: involvement of the p38MAPK pathway.
    Biomedical research (Tokyo, Japan), 2008, Volume: 29, Issue:1

    Topics: Animals; Cells, Cultured; Culture Media, Serum-Free; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Induction; Flavonoids; Imidazoles; Lysophosphatidylcholines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfonamides

2008
PGE2 inhibits basolateral 50 pS potassium channels in the thick ascending limb of the rat kidney.
    Kidney international, 2008, Volume: 74, Issue:4

    Topics: Animals; Cells, Cultured; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Imidazoles; Kidney; Kidney Cortex; Male; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Patch-Clamp Techniques; Phosphorylation; Potassium Channels, Inwardly Rectifying; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP3 Subtype; Specific Pathogen-Free Organisms

2008
15-deoxy-delta 12,14-prostaglandin J(2) inhibits the synthesis of the acute phase protein SIP24 in cartilage: Involvement of COX-2 in resolution of inflammation.
    Journal of cellular physiology, 2008, Volume: 217, Issue:2

    Topics: Acute-Phase Proteins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butyrates; Cartilage; Cells, Cultured; Chondrocytes; Cyclooxygenase 2; Diclofenac; Dinoprostone; Down-Regulation; Enzyme Induction; Enzyme Repression; Imidazoles; Inflammation; Intramolecular Oxidoreductases; Lipocalin-2; Lipocalins; Lipopolysaccharides; Mice; NF-kappa B; Oncogene Proteins; Oxazoles; p38 Mitogen-Activated Protein Kinases; Phenylurea Compounds; PPAR alpha; PPAR gamma; Prostaglandin D2; Prostaglandin-E Synthases; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Time Factors; Tyrosine

2008
The role of fatty acids and caveolin-1 in tumor necrosis factor alpha-induced endothelial cell activation.
    Metabolism: clinical and experimental, 2008, Volume: 57, Issue:10

    Topics: alpha-Linolenic Acid; Animals; Caveolae; Caveolin 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Endothelial Cells; Enzyme Activation; Imidazoles; Linoleic Acid; NF-kappa B; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Tumor Necrosis Factor, Type I; RNA, Small Interfering; Swine; Tumor Necrosis Factor-alpha; Up-Regulation

2008
The ceramide-1-phosphate analogue PCERA-1 modulates tumour necrosis factor-alpha and interleukin-10 production in macrophages via the cAMP-PKA-CREB pathway in a GTP-dependent manner.
    Immunology, 2010, Volume: 129, Issue:3

    Topics: Adenylyl Cyclases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bucladesine; Calcium Signaling; Cell Line; Cell Membrane; Ceramides; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Enzyme Inhibitors; Genes, Reporter; Guanosine Triphosphate; Imidazoles; Indoles; Interleukin-10; Isoquinolines; Lipopolysaccharides; Macrophages; Mice; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Response Elements; Ribosomal Protein S6 Kinases, 90-kDa; Rolipram; Signal Transduction; Sulfonamides; Transfection; Tumor Necrosis Factor-alpha

2010
Oxidized low-density lipoprotein increases interleukin-8 production in human gingival epithelial cell line Ca9-22.
    Journal of periodontal research, 2010, Volume: 45, Issue:4

    Topics: Cell Line, Tumor; Chemokine CCL2; Cholesterol 7-alpha-Hydroxylase; Dextran Sulfate; Dinoprostone; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Fucose; Gingiva; Humans; Imidazoles; Interleukin-1beta; Interleukin-8; Ketocholesterols; Lipoproteins, LDL; Mitogen-Activated Protein Kinases; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Periodontitis; Polysaccharides; Pyridines; Receptors, Scavenger; Sulfuric Acid Esters

2010
Stimulatory effects of areca nut extracts on prostaglandin E2 production by human polymorphonuclear leukocytes.
    Journal of periodontology, 2010, Volume: 81, Issue:5

    Topics: Adult; Areca; Blotting, Western; Butadienes; Calcium; Cell Survival; Cells, Cultured; Chelating Agents; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Imidazoles; Inflammation Mediators; Male; Neutrophils; Nitriles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Plant Extracts; Pyridines; Sulfonamides; Young Adult

2010
Inhibitory effect of vitamin K(2) on interleukin-1beta-stimulated proliferation of human osteoblasts.
    Biological & pharmaceutical bulletin, 2010, Volume: 33, Issue:5

    Topics: Adult; Anticoagulants; Bone Neoplasms; Cell Line; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Flavonoids; Glutamic Acid; Humans; Imidazoles; Interleukin-1; Interleukin-1beta; Male; Mitogen-Activated Protein Kinase Kinases; Nitrobenzenes; Osteoblasts; Osteocalcin; Osteosarcoma; p38 Mitogen-Activated Protein Kinases; Pregnane X Receptor; Protein Kinase Inhibitors; Pyridines; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; RNA, Messenger; Sulfonamides; Vitamin K; Vitamins; Warfarin; Young Adult

2010
Effects of florfenicol on LPS-induced nitric oxide and prostaglandin E₂ production in RAW 264.7 macrophages.
    Fundamental & clinical pharmacology, 2011, Volume: 25, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Cell Line; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Thiamphenicol

2011
Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-κB- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2011, Volume: 25, Issue:8

    Topics: Animals; Antibodies, Monoclonal; Ceramides; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Extremities; Hot Temperature; Hyperalgesia; Imidazoles; Injections; Male; Models, Biological; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pain Threshold; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiophenes; Touch

2011
The aromatic volatile organic compounds toluene, benzene and styrene induce COX-2 and prostaglandins in human lung epithelial cells via oxidative stress and p38 MAPK activation.
    Toxicology, 2011, Oct-28, Volume: 289, Issue:1

    Topics: Acetylcysteine; Air Pollutants; Benzene Derivatives; Blotting, Western; Cell Line; Cyclooxygenase 2; Dinoprost; Dinoprostone; Enzyme Activation; Enzyme Induction; Epithelial Cells; Glutathione; Humans; Imidazoles; Lung; MAP Kinase Kinase Kinases; Oxidative Stress; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Pyridines

2011
Prostaglandin E2 enhances interleukin-8 production via EP4 receptor in human pulmonary microvascular endothelial cells.
    American journal of physiology. Lung cellular and molecular physiology, 2012, Jan-15, Volume: 302, Issue:2

    Topics: Acute Lung Injury; Anthracenes; Butadienes; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Endothelial Cells; Humans; Imidazoles; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Lung; MAP Kinase Signaling System; Methyl Ethers; Microvessels; Naphthalenes; Neutrophils; Nitriles; p38 Mitogen-Activated Protein Kinases; Phenylbutyrates; Pyridines; Receptors, Prostaglandin E, EP4 Subtype; Respiratory Distress Syndrome; RNA, Messenger; Thionucleotides

2012
Interaction between head and neck squamous cell carcinoma cells and fibroblasts in the biosynthesis of PGE2.
    Journal of lipid research, 2012, Volume: 53, Issue:4

    Topics: Arachidonic Acid; Carcinoma, Squamous Cell; Cell Movement; Cell Proliferation; Chemical Fractionation; Coculture Techniques; Culture Media, Conditioned; Cyclooxygenase 2; Dinoprostone; Fibroblasts; Head and Neck Neoplasms; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Interleukin-1; Intramolecular Oxidoreductases; Neovascularization, Pathologic; Prostaglandin-E Synthases; Prostaglandins F; Protein Array Analysis; Protein Stability; Pyridines; Receptors, Interleukin-1; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; Tumor Cells, Cultured

2012
EGCG blocks TGFβ1-induced CCN2 by suppressing JNK and p38 in buccal fibroblasts.
    Clinical oral investigations, 2013, Volume: 17, Issue:2

    Topics: Anthracenes; Benzamides; Catechin; Cell Line; Cells, Cultured; Connective Tissue Growth Factor; Dinoprostone; Dioxoles; Dose-Response Relationship, Drug; Fibroblasts; Flavonoids; Humans; Imidazoles; Lung; MAP Kinase Kinase 4; Mouth Mucosa; Oral Submucous Fibrosis; p38 Mitogen-Activated Protein Kinases; Protease Inhibitors; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta1

2013
Effects of vascular endothelial cells on osteogenic differentiation of noncontact co-cultured periodontal ligament stem cells under hypoxia.
    Journal of periodontal research, 2013, Volume: 48, Issue:1

    Topics: Adult; Alkaline Phosphatase; Animals; Calcification, Physiologic; Cell Culture Techniques; Cell Differentiation; Cell Hypoxia; Coculture Techniques; Core Binding Factor Alpha 1 Subunit; Dinoprostone; Endothelial Cells; Endothelium, Vascular; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Osteoblasts; Osteogenesis; p38 Mitogen-Activated Protein Kinases; Paracrine Communication; Periodontal Ligament; Pyridines; Sp7 Transcription Factor; Stem Cells; Transcription Factors; Vascular Endothelial Growth Factor A

2013
p38/AP-1 pathway in lipopolysaccharide-induced inflammatory responses is negatively modulated by electrical stimulation.
    Mediators of inflammation, 2013, Volume: 2013

    Topics: Animals; Cell Line; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Electric Stimulation; Humans; Imidazoles; Inflammation; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Pyridines; Transcription Factor AP-1; Tumor Necrosis Factor-alpha

2013
Cyclic tensile force up-regulates BMP-2 expression through MAP kinase and COX-2/PGE2 signaling pathways in human periodontal ligament cells.
    Experimental cell research, 2014, Apr-15, Volume: 323, Issue:1

    Topics: Adult; Bite Force; Bone Morphogenetic Protein 2; Butadienes; Calcification, Physiologic; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Humans; Imidazoles; Male; Mastication; Molar, Third; Nitriles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Stress, Physiological; Sulfonamides; Up-Regulation; Young Adult

2014
Geniposide suppresses LPS-induced nitric oxide, PGE2 and inflammatory cytokine by downregulating NF-κB, MAPK and AP-1 signaling pathways in macrophages.
    International immunopharmacology, 2014, Volume: 20, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Butadienes; Cell Line; Cyclooxygenase 2; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Gardenia; Imidazoles; Inflammation Mediators; Interleukin-6; Iridoids; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred Strains; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Nitriles; Pyridines; Signal Transduction; Sulfones; Transcription Factor AP-1; Tumor Necrosis Factor-alpha

2014
Cyclooxygenase 2-mediated apoptotic and inflammatory responses in photodynamic therapy treated breast adenocarcinoma cells and xenografts.
    Journal of photochemistry and photobiology. B, Biology, 2014, May-05, Volume: 134

    Topics: Acetylcysteine; Adenocarcinoma; Animals; Apoptosis; Breast Neoplasms; Cyclooxygenase 2; Dinoprostone; Female; Humans; Imidazoles; Interleukin-1beta; Light; MCF-7 Cells; Mice; Mice, Inbred BALB C; Photosensitizing Agents; Pyridines; Reactive Oxygen Species; Signal Transduction; Transplantation, Heterologous; Tumor Necrosis Factor-alpha

2014
Helicobacter pylori promotes VEGF expression via the p38 MAPK‑mediated COX‑2‑PGE2 pathway in MKN45 cells.
    Molecular medicine reports, 2014, Volume: 10, Issue:4

    Topics: Cell Line, Tumor; Cyclooxygenase 2; Dinoprostone; HEK293 Cells; Helicobacter pylori; Humans; Imidazoles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; RNA Interference; RNA, Small Interfering; Sulfonamides; Up-Regulation; Vascular Endothelial Growth Factor A

2014
Regulation by resveratrol of prostaglandin E2-stimulated osteoprotegerin synthesis in osteoblasts.
    International journal of molecular medicine, 2014, Volume: 34, Issue:5

    Topics: 3T3 Cells; Animals; Anthracenes; Dinoprostone; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinase 1; Osteoblasts; Osteoprotegerin; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Resveratrol; Sirtuin 1; Stilbenes

2014
DJ-1 mutation decreases astroglial release of inflammatory mediators.
    Neurotoxicology, 2016, Volume: 52

    Topics: Animals; Anthracenes; Astrocytes; Butadienes; Cyclooxygenase 2; Dinoprostone; Imidazoles; Inflammation Mediators; Lipopolysaccharides; Mice; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type II; Nitriles; Primary Cell Culture; Protein Deglycase DJ-1; Pyridines; Tumor Necrosis Factor-alpha

2016
Hippocampal CA1 βCaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression.
    Journal of neuroinflammation, 2018, Dec-08, Volume: 15, Issue:1

    Topics: Adenoviridae; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cyclooxygenase 2; Cytokines; Depression; Dinoprostone; Disease Models, Animal; Food Preferences; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Imidazoles; Lipopolysaccharides; Male; Pyridines; Rats; Rats, Sprague-Dawley; RNA Interference; Stress, Psychological; Swimming

2018
Cellular Microenvironment Stiffness Regulates Eicosanoid Production and Signaling Pathways.
    American journal of respiratory cell and molecular biology, 2020, Volume: 63, Issue:6

    Topics: Cellular Microenvironment; Cyclooxygenase 2; Dinoprostone; Fibroblasts; Humans; Idiopathic Pulmonary Fibrosis; Imidazoles; Lung; Prostaglandin-E Synthases; Pyridines; Signal Transduction

2020