sb 203580 has been researched along with dinoprostone in 63 studies
Studies (sb 203580) | Trials (sb 203580) | Recent Studies (post-2010) (sb 203580) | Studies (dinoprostone) | Trials (dinoprostone) | Recent Studies (post-2010) (dinoprostone) |
---|---|---|---|---|---|
3,489 | 4 | 1,137 | 29,105 | 1,346 | 6,357 |
Protein | Taxonomy | sb 203580 (IC50) | dinoprostone (IC50) |
---|---|---|---|
Prostaglandin E2 receptor EP1 subtype | Homo sapiens (human) | 0.0155 | |
Prostaglandin E2 receptor EP4 subtype | Homo sapiens (human) | 0.0031 | |
Prostaglandin E2 receptor EP4 subtype | Rattus norvegicus (Norway rat) | 0.0021 | |
Prostaglandin E2 receptor EP3 subtype | Homo sapiens (human) | 0.002 | |
Prostaglandin E2 receptor EP2 subtype | Homo sapiens (human) | 0.0087 | |
Prostacyclin receptor | Homo sapiens (human) | 0.26 | |
Prostaglandin E2 receptor EP2 subtype | Rattus norvegicus (Norway rat) | 0.0052 |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 2 (3.17) | 18.2507 |
2000's | 41 (65.08) | 29.6817 |
2010's | 19 (30.16) | 24.3611 |
2020's | 1 (1.59) | 2.80 |
Authors | Studies |
---|---|
Brook, M; Clark, AR; Dean, JL; Ridley, SH; Saklatvala, J; Sarsfield, SJ | 1 |
Abramson, SB; Amin, AR; Attur, MG; Dave, MN; Kumar, S; Lee, JC; Patel, R | 1 |
Barnes, PJ; Cambridge, L; Hart, LA; Lindsay, MA; Newton, R; Stevens, DA | 1 |
Creminon, C; Hla, T; Huang, CK; Jang, BC; Liu, CH; Sanchez, T; Schaefers, HJ; Trifan, OC | 1 |
Lahiri, T; Laporte, JD; Moore, PE; Panettieri, RA; Schwartzman, IN; Shore, SA | 1 |
Brune, K; Hinz, B; Pahl, A; Ramer, R | 1 |
Cho, CH; Fan, XM; Kung, HF; Lam, SK; Lin, MC; Wang, WP; Wong, BC | 1 |
Chan, ED; Cooper, AM; Fouts, D; Josephy, SI; Tse, HM | 1 |
Ertl, G; Jacobs, M; Scheuren, N; Schorb, W | 1 |
Kato, K; Kozawa, O; Matsuno, H; Niwa, M; Tokuda, H; Uematsu, T | 1 |
Fujita, N; Ishida, A; Kitazawa, R; Tsuruo, T | 1 |
Akahoshi, M; Arinobu, Y; Harada, M; Inoue, Y; Miyake, K; Nagano, S; Nakashima, H; Niho, Y; Niiro, H; Ogami, E; Otsuka, T; Yamaoka, K | 1 |
Itoh, K; Li, X; Murase, Y; Nishihara, T; Suda, K; Suda, T; Takahashi, N; Udagawa, N | 1 |
Demetris, AJ; Han, C; Lunz, JG; Michalopoulos, G; Shelhamer, JH; Wu, T | 1 |
Berenbaum, F; Bereziat, G; Humbert, L; Thirion, S | 1 |
Harada, R; Kobayashi, M; Nakata, H; Taguchi, H; Uemura, Y | 1 |
Binder, BR; Bochkov, VN; Huber, J; Leitinger, N | 1 |
Lai, WC; Peng, G; Shankavaram, U; Wahl, LM; Zhou, M | 1 |
Akahoshi, M; Arinobu, Y; Harada, M; Inoue, Y; Miyake, K; Nagano, S; Nakashima, H; Niiro, H; Ninomiya, I; Ogami, E; Otsuka, T; Shimizu, S | 1 |
Cui, Y; Kim, DS; Kim, SK; Kwon, SB; Park, KC; Park, SH; Yoon, JA | 1 |
Hosoe, M; Katoh, T; Komurasaki, T; Mikami, Y; Miyahara, T; Nemoto, N; Sakuma, T; Takayama, K; Uchida, S; Watanabe, M | 1 |
Catapano, AL; Inoue, H; Norata, GD; Pellegatta, F; Pirillo, A | 1 |
Chu, CR; Studer, RK | 1 |
Kim, H; Kokkotou, E; LaMont, JT; Moyer, MP; Na, X; Pothoulakis, C; Rhee, SH; Savidge, T | 1 |
Bagnato, A; Di Castro, V; Elia, G; Natali, PG; Rosanò, L; Spinella, F | 1 |
Gutiérrez-Venegas, G; Kawasaki-Cárdenas, P; Maldonado-Frías, S; Ontiveros-Granados, A | 1 |
Jang, JH; Surh, YJ | 1 |
Goldring, MB; Jalonen, U; Kankaanranta, H; Lahti, A; Leinonen, S; Moilanen, E; Nieminen, R; Vuolteenaho, K | 1 |
Kawakami, T; Olsson, T; Yucel-Lindberg, T | 1 |
Clemente, D; Correa, F; Docagne, F; Guaza, C; Mestre, L | 1 |
Frias, MA; Gerber-Wicht, C; Lang, U; Rebsamen, MC | 1 |
Ashizuka, M; Ito, S; Kubota, Y; Ogata, S; Satoh, S; Shirasuna, K; Takeuchi, H | 1 |
Birnbaumer, L; Edwards, RA; Hoang, B; Trinh, A | 1 |
Freeman, MR; Kim, J; Misonou, Y; Park, YS; Takahashi, M; Takamiya, R; Taniguchi, N | 1 |
Acquaviva, AM; Acquaviva, F; di Palma, A; Di Prisco, AM; Giannouli, M; Iuliano, F; Leone, V; Ricchi, P | 1 |
Gho, YS; Lee, EH; Lee, KH; Nam, KN; Yun, SJ | 1 |
Aikawa, N; Fukuda, K; Hori, S; Manabe-Kawaguchi, H; Miyatake, S; Watanabe, K | 1 |
Chen, Z; Guo, YS; Hellmich, MR; Ko, TC; Townsend, CM; Wen, XD | 1 |
Bachelet, M; Bardin, S; Broquet, AH; Gasnereau, I; Jouniaux, AM; Lenoir, C; Masliah, J; Sapin, C; Seksik, P; Thomas, G; Trugnan, G | 1 |
Kadonosono, K; Kamei, J; Ohnaka, K; Tanaka, S; Utsunomiya, H; Yamakawa, T | 1 |
Gu, R; Jin, Y; Kong, S; Li, W; Wang, L; Wang, WH; Yang, B; Yang, L; Zhai, Y; Zhang, C; Zhang, Y | 1 |
Cancedda, FD; Cancedda, R; Ulivi, V | 1 |
Hennig, B; Lim, EJ; Toborek, M; Wang, L | 1 |
Avni, D; Meijler, MM; Philosoph, A; Zor, T | 1 |
Itabe, H; Kato, R; Obama, T; Sakiyama, Y; Suzuki, K; Usui, M; Yamamoto, M | 1 |
Chang, HW; Hung, SL; Lai, YL; Lee, YY; Liu, TY; Wu, CY | 1 |
Kondo, A; Matsuda, T; Togari, A; Tsunashima, Y | 1 |
Deng, X; Li, H; Xiong, H; Yu, L; Zhang, X | 1 |
Chen, Z; Doyle, T; Muscoli, C; Obeid, LM; Salvemini, D | 1 |
Baumann, S; Böhme, A; Kohajda, T; Lehmann, I; Mögel, I; Simon, JC; von Bergen, M | 1 |
Aso, H; Hasegawa, Y; Imaizumi, K; Ito, S; Kondo, M; Mori, A; Morioka, M; Suganuma, N | 1 |
Alcolea, S; Alfranca, A; Antón, R; Avilés-Jurado, FX; Camacho, M; León, X; Quer, M; Redondo, JM; Soler, M; Vila, L | 1 |
Chang, JZ; Chen, HM; Deng, YT; Kuo, MY; Yang, WH | 1 |
Cao, H; Gu, Y; Wu, Y; Yang, Y; Yin, J; Zhang, L; Zhang, Y; Zhao, X; Zhao, Z; Zhou, Y | 1 |
Cho, JY; Jeong, D; Kim, KW; Lee, J; Yang, Y; Yi, YS | 1 |
Nemoto, E; Shimauchi, H; Suzuki, R | 1 |
Cao, J; Fang, L; Fu, J; Ge, D; Li, X; Liu, Z; Ran, J; Ran, Y; Shi, Q; Wang, L; Zhang, H; Zhao, H; Zheng, X; Zhou, Y | 1 |
Chen, Q; Song, J; Wei, Y; Xing, D | 1 |
Fu, X; Li, Q; Liu, N; Liu, X; Sui, H; Wang, Y; Wu, Q; Ye, N; Yu, NA; Zhou, L; Zhou, N | 1 |
Kondo, A; Kozawa, O; Kuroyanagi, G; Matsushima-Nishiwaki, R; Mizutani, J; Otsuka, T; Tokuda, H; Yamamoto, N | 1 |
Ashley, AK; Hanneman, WH; Hinds, AI; Legare, ME; Tjalkens, RB | 1 |
Fan, C; Li, Y; Song, Q; Wang, P; Yang, M; Yu, SY | 1 |
Alhamdoosh, M; Berhan, A; Harris, T; Jaffar, J; Jativa, F; Langenbach, S; Lee, P; Lönnstedt, I; Ng, M; Stewart, AG; Westall, G; Wilson, M; Wilson, N | 1 |
63 other study(ies) available for sb 203580 and dinoprostone
Article | Year |
---|---|
A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase-2 mRNA.
Topics: Arachidonic Acids; Calcium-Calmodulin-Dependent Protein Kinases; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Enzyme Inhibitors; HeLa Cells; Humans; Imidazoles; Interleukin-1; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Membrane Proteins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines; RNA, Messenger | 1998 |
Regulation of nitric oxide and prostaglandin E2 production by CSAIDS (SB203580) in murine macrophages and bovine chondrocytes stimulated with LPS.
Topics: Animals; Anti-Inflammatory Agents; Cattle; Cell Line; Chondrocytes; Cyclooxygenase 2; Dinoprostone; Humans; Hydrocortisone; Imidazoles; Isoenzymes; Lipopolysaccharides; Macrophages; Membrane Proteins; Mice; Nitric Oxide; Prostaglandin-Endoperoxide Synthases; Pyridines | 1999 |
The MAP kinase inhibitors, PD098059, UO126 and SB203580, inhibit IL-1beta-dependent PGE(2) release via mechanistically distinct processes.
Topics: Arachidonic Acid; Butadienes; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Interleukin-1; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; Time Factors; Tumor Cells, Cultured | 2000 |
Serum withdrawal-induced post-transcriptional stabilization of cyclooxygenase-2 mRNA in MDA-MB-231 mammary carcinoma cells requires the activity of the p38 stress-activated protein kinase.
Topics: Apoptosis; Blotting, Northern; Blotting, Western; Breast Neoplasms; Bromodeoxyuridine; Cell Cycle; Cell Nucleus; Culture Media, Serum-Free; Cyclooxygenase 2; Dactinomycin; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Genes, Dominant; Humans; Imidazoles; Isoenzymes; Membrane Proteins; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines; RNA Processing, Post-Transcriptional; RNA, Messenger; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured | 2000 |
p38 MAP kinase regulates IL-1 beta responses in cultured airway smooth muscle cells.
Topics: Bucladesine; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Humans; Imidazoles; Interleukin-1; Isoenzymes; Isoproterenol; Leupeptins; Membrane Proteins; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; Transcription Factor AP-1 | 2000 |
R(+)-methanandamide induces cyclooxygenase-2 expression in human neuroglioma cells via a non-cannabinoid receptor-mediated mechanism.
Topics: Analgesics, Non-Narcotic; Arachidonic Acids; Blotting, Western; Brain Neoplasms; Cannabinoid Receptor Modulators; Cell Line; Central Nervous System; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Dronabinol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glioma; Humans; Imidazoles; Interleukin-1; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Piperidines; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Receptors, Cannabinoid; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella | 2001 |
Interleukin-1beta induces cyclo-oxygenase-2 expression in gastric cancer cells by the p38 and p44/42 mitogen-activated protein kinase signaling pathways.
Topics: Adenocarcinoma; Blotting, Western; Cyclooxygenase 2; Dinoprostone; Enzyme Inhibitors; Flavonoids; Gene Expression; Humans; Imidazoles; Interleukin-1; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Stomach Neoplasms; Tumor Cells, Cultured; Up-Regulation | 2001 |
Activation of the mitogen-activated protein kinase signaling pathway is instrumental in determining the ability of Mycobacterium avium to grow in murine macrophages.
Topics: Animals; Bone Marrow Cells; Cell Division; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Female; Growth Inhibitors; Imidazoles; Indomethacin; Interleukin-10; Interleukin-12; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Macrophages; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mycobacterium avium; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Tumor Necrosis Factor-alpha; Virulence | 2002 |
Cyclooxygenase-2 in myocardium stimulation by angiotensin-II in cultured cardiac fibroblasts and role at acute myocardial infarction.
Topics: Angiotensin II; Animals; Blotting, Western; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Egg Proteins; Enzyme Inhibitors; Female; Fibroblasts; Flavonoids; Imidazoles; Immunoblotting; Immunoenzyme Techniques; Immunohistochemistry; Isoenzymes; Lactones; Macrophages; Membrane Glycoproteins; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Myocardium; Necrosis; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyridines; Rats; Rats, Wistar; Receptors, Cell Surface; Sulfones; Time Factors; Vimentin; Zona Pellucida Glycoproteins | 2002 |
Mechanism of prostaglandin E2-stimulated heat shock protein 27 induction in osteoblast-like MC3T3-E1 cells.
Topics: Analysis of Variance; Animals; Butadienes; Calcium; Calcium Channel Blockers; Cell Line; Chelating Agents; Dinoprostone; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Gallic Acid; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Imidazoles; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Molecular Chaperones; Naphthalenes; Neoplasm Proteins; Nitriles; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Pyridines; Pyrrolidinones; Staurosporine; Stimulation, Chemical; Time Factors; Type C Phospholipases | 2002 |
Transforming growth factor-beta induces expression of receptor activator of NF-kappa B ligand in vascular endothelial cells derived from bone.
Topics: Animals; Bone and Bones; Carbazoles; Carrier Proteins; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Endothelium, Vascular; Enzyme Inhibitors; Humans; Imidazoles; Indoles; Membrane Glycoproteins; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Osteoclasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Pyridines; Pyrroles; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; RNA, Messenger; Transforming Growth Factor beta | 2002 |
Molecular mechanisms of lipopolysaccharide-induced cyclooxygenase-2 expression in human neutrophils: involvement of the mitogen-activated protein kinase pathway and regulation by anti-inflammatory cytokines.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Interleukin-10; Interleukin-4; Isoenzymes; Lipopolysaccharides; Membrane Proteins; Mitogen-Activated Protein Kinases; Neutrophils; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; Signal Transduction | 2002 |
p38 MAPK-mediated signals are required for inducing osteoclast differentiation but not for osteoclast function.
Topics: Animals; Calcitriol; Carrier Proteins; Cell Differentiation; Dinoprostone; Imidazoles; Lipopolysaccharides; Male; Membrane Glycoproteins; Mice; Mitogen-Activated Protein Kinases; Osteoclasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B | 2002 |
Involvement of 85-kd cytosolic phospholipase A(2) and cyclooxygenase-2 in the proliferation of human cholangiocarcinoma cells.
Topics: Arachidonic Acids; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Division; Cholangiocarcinoma; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytosol; Dinoprost; Dinoprostone; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Humans; Imidazoles; Interleukin-6; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinases; Nitrobenzenes; Organophosphonates; Phospholipases A; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; Sulfonamides; Tumor Cells, Cultured | 2002 |
Concomitant recruitment of ERK1/2 and p38 MAPK signalling pathway is required for activation of cytoplasmic phospholipase A2 via ATP in articular chondrocytes.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Biological Transport; Blotting, Western; Cartilage, Articular; Chondrocytes; Cytoplasm; Dinoprostone; DNA, Complementary; Dose-Response Relationship, Drug; Electrophoresis; Enzyme Activation; Female; Flavonoids; Genes, Dominant; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Polymerase Chain Reaction; Pyridines; Rabbits; Signal Transduction; Time Factors | 2003 |
Cyclooxygenase-2 inhibitor NS-398 suppresses cell growth and constitutive production of granulocyte-colony stimulating factor and granulocyte macrophage-colony stimulating factor in lung cancer cells.
Topics: Cell Division; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Progression; Drug Screening Assays, Antitumor; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Imidazoles; Interleukin-1; Isoenzymes; Lung Neoplasms; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Proteins; NF-kappa B; Nitrobenzenes; Proline; Prostaglandin-Endoperoxide Synthases; Pyridines; Recombinant Proteins; Sulfonamides; Thiocarbamates; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2003 |
The isoprostane 8-iso-PGE2 stimulates endothelial cells to bind monocytes via cyclic AMP- and p38 MAP kinase-dependent signaling pathways.
Topics: Arteriosclerosis; Blotting, Western; Cell Adhesion; Cell Communication; Cells, Cultured; Coculture Techniques; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Humans; Imidazoles; Isoprostanes; Leukocytes; Mitogen-Activated Protein Kinases; Monocytes; Neutrophils; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Binding; Pyridines; Signal Transduction; Time Factors | 2003 |
Differential regulation of lipopolysaccharide-induced monocyte matrix metalloproteinase (MMP)-1 and MMP-9 by p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases.
Topics: Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Isoenzymes; Lipopolysaccharides; Matrix Metalloproteinase 1; Matrix Metalloproteinase 9; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Monocytes; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Pyridines; Transcription Factors | 2003 |
Novel regulatory mechanisms of CD40-induced prostanoid synthesis by IL-4 and IL-10 in human monocytes.
Topics: Antibodies, Monoclonal; Carrier Proteins; CD40 Antigens; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Flavonoids; Humans; Imidazoles; Interleukin-10; Interleukin-4; Isoenzymes; Ligands; MAP Kinase Signaling System; Membrane Proteins; Monocytes; NF-kappa B; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Protein Transport; Pyridines; Recombinant Proteins; Repressor Proteins; Sulfonamides | 2004 |
Involvement of ERK AND p38 MAP kinase in AAPH-induced COX-2 expression in HaCaT cells.
Topics: Amidines; Catechin; Chromans; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Humans; Imidazoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Keratinocytes; MAP Kinase Kinase 4; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines | 2004 |
Involvement of mitogen-activated protein kinases and protein kinase C in cadmium-induced prostaglandin E2 production in primary mouse osteoblastic cells.
Topics: Animals; Blotting, Western; Cadmium; Dinoprostone; Enzyme Inhibitors; Female; Flavonoids; Imidazoles; Kinetics; Mice; Mitogen-Activated Protein Kinases; Naphthalenes; Osteoblasts; Phospholipases A; Phospholipases A2; Phosphorylation; Pregnancy; Protein Kinase C; Pyridines; Signal Transduction | 2004 |
Native LDL and oxidized LDL modulate cyclooxygenase-2 expression in HUVECs through a p38-MAPK, NF-kappaB, CRE dependent pathway and affect PGE2 synthesis.
Topics: Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Induction; Enzyme Inhibitors; Epoprostenol; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Immunoassay; Immunoblotting; Immunohistochemistry; Indomethacin; Lipoproteins, LDL; Membrane Proteins; NF-kappa B; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Prostaglandin-Endoperoxide Synthases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Thromboxane A2; Time Factors; Umbilical Veins | 2004 |
p38 MAPK and COX2 inhibition modulate human chondrocyte response to TGF-beta.
Topics: Cell Proliferation; Chondrocytes; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Humans; Imidazoles; Interleukin-1; p38 Mitogen-Activated Protein Kinases; Proteoglycans; Pyridines; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta | 2005 |
Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK.
Topics: Animals; Bacterial Toxins; Cell Line; Colon; Cyclic AMP; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enterotoxins; Enzyme Activation; Enzyme Inhibitors; Humans; Ileum; Imidazoles; Immunohistochemistry; Inflammation; Intramolecular Oxidoreductases; Luciferases; Membrane Proteins; Mice; Mice, SCID; Models, Biological; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostaglandin-E Synthases; Prostaglandin-Endoperoxide Synthases; Protein Binding; Pyridines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Signal Transduction; Sulfonamides; Time Factors; Tissue Transplantation; Transfection | 2005 |
Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian cancer cells through multiple signaling pathways: evidence for involvement of transactivation of the epidermal growth factor receptor.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Endothelin A Receptor Antagonists; Endothelin-1; Enzyme Induction; ErbB Receptors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Peptides, Cyclic; Protein Kinase Inhibitors; Pyridines; Quinazolines; Receptor, Endothelin A; Signal Transduction; Transcriptional Activation; Tyrphostins | 2004 |
Role of p38 in nitric oxide synthase and cyclooxygenase expression, and nitric oxide and PGE2 synthesis in human gingival fibroblasts stimulated with lipopolysaccharides.
Topics: Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Fibroblasts; Gingiva; Humans; Imidazoles; Lipopolysaccharides; Membrane Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Protein Kinase Inhibitors; Pyridines; RNA, Messenger | 2005 |
Beta-amyloid-induced apoptosis is associated with cyclooxygenase-2 up-regulation via the mitogen-activated protein kinase-NF-kappaB signaling pathway.
Topics: Amyloid beta-Peptides; Animals; Apoptosis; Butadienes; Celecoxib; Cyclooxygenase 2; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Peptide Fragments; Poly(ADP-ribose) Polymerases; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Rats; Sulfonamides; Up-Regulation | 2005 |
Inhibitors of mitogen-activated protein kinases downregulate COX-2 expression in human chondrocytes.
Topics: Anthracenes; Chondrocytes; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Interleukin-1; Mitogen-Activated Protein Kinases; Pyridines; RNA, Messenger; Signal Transduction | 2005 |
Signal pathways involved in the regulation of prostaglandin E synthase-1 in human gingival fibroblasts.
Topics: Arachidonic Acid; Blotting, Western; Cells, Cultured; Child; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression Regulation; Gingiva; Humans; Imidazoles; Indoles; Interleukin-1beta; Intramolecular Oxidoreductases; Maleimides; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Prostaglandin D2; Prostaglandin-E Synthases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha | 2006 |
The synthetic cannabinoid WIN 55,212-2 increases COX-2 expression and PGE2 release in murine brain-derived endothelial cells following Theiler's virus infection.
Topics: Animals; Arachidonic Acids; Benzoxazines; Brain; Cell Nucleus; Cell Survival; Chromones; Cyclooxygenase 2; Dinoprostone; Endocannabinoids; Endothelial Cells; Enzyme Activation; Flavonoids; Fluorescent Antibody Technique; Glycerides; Imidazoles; Mice; Microscopy, Confocal; Mitogen-Activated Protein Kinases; Morpholines; Naphthalenes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Resorcinols; Theilovirus | 2006 |
Prostaglandin E2 activates Stat3 in neonatal rat ventricular cardiomyocytes: A role in cardiac hypertrophy.
Topics: Animals; Animals, Newborn; Blotting, Western; Butadienes; Cardiomegaly; Cells, Cultured; Cycloheximide; Dactinomycin; Dinoprostone; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Gene Silencing; Genistein; Imidazoles; Janus Kinases; Myocytes, Cardiac; Nitriles; Phosphorylation; Protein Synthesis Inhibitors; Pyridines; Rats; Rats, Wistar; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; RNA Interference; Signal Transduction; STAT3 Transcription Factor; Stress, Mechanical | 2007 |
Ca2+ stimulates COX-2 expression through calcium-sensing receptor in fibroblasts.
Topics: Anthracenes; Bone and Bones; Calcium; Calcium Signaling; Cations, Divalent; Cyclooxygenase 2; Dinoprostone; Estrenes; Fibroblasts; Flavonoids; Humans; Imidazoles; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Pyrrolidinones; Receptors, Calcium-Sensing; RNA, Messenger; Type C Phospholipases | 2006 |
Decreased MAPK- and PGE2-dependent IL-11 production in Gialpha2-/- colonic myofibroblasts.
Topics: 16,16-Dimethylprostaglandin E2; Alprostadil; Animals; Cells, Cultured; Colon; Cyclic AMP; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; GTP-Binding Protein alpha Subunit, Gi2; Imidazoles; Interleukin-11; Interleukin-1beta; Intestine, Small; Methyl Ethers; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta | 2007 |
Acrolein induces cyclooxygenase-2 and prostaglandin production in human umbilical vein endothelial cells: roles of p38 MAP kinase.
Topics: Acetophenones; Acrolein; Animals; Atherosclerosis; Benzopyrans; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Induction; Humans; Imidazoles; Lung; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Protein Kinase C-delta; Protein Kinase Inhibitors; Pyridines; RNA, Messenger; Smoking; Time Factors; Transcription, Genetic; Umbilical Veins | 2007 |
PGE2 inhibits apoptosis in human adenocarcinoma Caco-2 cell line through Ras-PI3K association and cAMP-dependent kinase A activation.
Topics: Apoptosis; Caco-2 Cells; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Humans; Imidazoles; Isoquinolines; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyridines; ras Proteins; Sulfonamides | 2007 |
Activation of microglial cells by ceruloplasmin.
Topics: Animals; Cell Line, Transformed; Cell Survival; Ceruloplasmin; Dinoprostone; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; Lipopolysaccharides; Mice; Microglia; NF-kappaB-Inducing Kinase; Nitric Oxide; Protein Serine-Threonine Kinases; Pyridines; RNA, Messenger; Time Factors; Tumor Necrosis Factor-alpha | 2007 |
Prostaglandin E2 induces hypertrophic changes and suppresses alpha-skeletal actin gene expression in rat cardiomyocytes.
Topics: Actins; Animals; Animals, Newborn; Atrial Natriuretic Factor; Blotting, Western; Butadienes; Cell Enlargement; Cell Size; Cells, Cultured; Dinoprostone; Gene Expression; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Naphthalenes; Natriuretic Peptide, Brain; Nitriles; Phenylbutyrates; Phosphorylation; Prostaglandin Antagonists; Protein Biosynthesis; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Reverse Transcriptase Polymerase Chain Reaction | 2007 |
Synergistic regulation of COX-2 expression by bombesin and transforming growth factor-beta.
Topics: Animals; Bombesin; Cell Line; Cyclooxygenase 2; Dinoprostone; Enzyme Induction; Imidazoles; Intestinal Mucosa; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Protein Kinase Inhibitors; Pyridines; Rats; RNA Interference; RNA Stability; RNA, Messenger; Signal Transduction; Time Factors; Transcription, Genetic; Transfection; Transforming Growth Factor beta1 | 2008 |
MD-2 controls bacterial lipopolysaccharide hyporesponsiveness in human intestinal epithelial cells.
Topics: Anthracenes; Caco-2 Cells; Cell Line, Tumor; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Flow Cytometry; Gene Expression; HT29 Cells; Humans; Imidazoles; Interleukin-8; Intestines; Lipopolysaccharides; Lymphocyte Antigen 96; Mitogen-Activated Protein Kinases; Monocytes; NF-kappa B; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Toll-Like Receptor 4; Transfection | 2008 |
Cyclooxygenase-2 induction by lysophosphatidylcholine in cultured rat vascular smooth muscle cells: involvement of the p38MAPK pathway.
Topics: Animals; Cells, Cultured; Culture Media, Serum-Free; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Induction; Flavonoids; Imidazoles; Lysophosphatidylcholines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfonamides | 2008 |
PGE2 inhibits basolateral 50 pS potassium channels in the thick ascending limb of the rat kidney.
Topics: Animals; Cells, Cultured; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Imidazoles; Kidney; Kidney Cortex; Male; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Patch-Clamp Techniques; Phosphorylation; Potassium Channels, Inwardly Rectifying; Protein Kinase C; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP3 Subtype; Specific Pathogen-Free Organisms | 2008 |
15-deoxy-delta 12,14-prostaglandin J(2) inhibits the synthesis of the acute phase protein SIP24 in cartilage: Involvement of COX-2 in resolution of inflammation.
Topics: Acute-Phase Proteins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butyrates; Cartilage; Cells, Cultured; Chondrocytes; Cyclooxygenase 2; Diclofenac; Dinoprostone; Down-Regulation; Enzyme Induction; Enzyme Repression; Imidazoles; Inflammation; Intramolecular Oxidoreductases; Lipocalin-2; Lipocalins; Lipopolysaccharides; Mice; NF-kappa B; Oncogene Proteins; Oxazoles; p38 Mitogen-Activated Protein Kinases; Phenylurea Compounds; PPAR alpha; PPAR gamma; Prostaglandin D2; Prostaglandin-E Synthases; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Time Factors; Tyrosine | 2008 |
The role of fatty acids and caveolin-1 in tumor necrosis factor alpha-induced endothelial cell activation.
Topics: alpha-Linolenic Acid; Animals; Caveolae; Caveolin 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Endothelial Cells; Enzyme Activation; Imidazoles; Linoleic Acid; NF-kappa B; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Tumor Necrosis Factor, Type I; RNA, Small Interfering; Swine; Tumor Necrosis Factor-alpha; Up-Regulation | 2008 |
The ceramide-1-phosphate analogue PCERA-1 modulates tumour necrosis factor-alpha and interleukin-10 production in macrophages via the cAMP-PKA-CREB pathway in a GTP-dependent manner.
Topics: Adenylyl Cyclases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bucladesine; Calcium Signaling; Cell Line; Cell Membrane; Ceramides; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Enzyme Inhibitors; Genes, Reporter; Guanosine Triphosphate; Imidazoles; Indoles; Interleukin-10; Isoquinolines; Lipopolysaccharides; Macrophages; Mice; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Response Elements; Ribosomal Protein S6 Kinases, 90-kDa; Rolipram; Signal Transduction; Sulfonamides; Transfection; Tumor Necrosis Factor-alpha | 2010 |
Oxidized low-density lipoprotein increases interleukin-8 production in human gingival epithelial cell line Ca9-22.
Topics: Cell Line, Tumor; Chemokine CCL2; Cholesterol 7-alpha-Hydroxylase; Dextran Sulfate; Dinoprostone; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Fucose; Gingiva; Humans; Imidazoles; Interleukin-1beta; Interleukin-8; Ketocholesterols; Lipoproteins, LDL; Mitogen-Activated Protein Kinases; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Periodontitis; Polysaccharides; Pyridines; Receptors, Scavenger; Sulfuric Acid Esters | 2010 |
Stimulatory effects of areca nut extracts on prostaglandin E2 production by human polymorphonuclear leukocytes.
Topics: Adult; Areca; Blotting, Western; Butadienes; Calcium; Cell Survival; Cells, Cultured; Chelating Agents; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Imidazoles; Inflammation Mediators; Male; Neutrophils; Nitriles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Plant Extracts; Pyridines; Sulfonamides; Young Adult | 2010 |
Inhibitory effect of vitamin K(2) on interleukin-1beta-stimulated proliferation of human osteoblasts.
Topics: Adult; Anticoagulants; Bone Neoplasms; Cell Line; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Flavonoids; Glutamic Acid; Humans; Imidazoles; Interleukin-1; Interleukin-1beta; Male; Mitogen-Activated Protein Kinase Kinases; Nitrobenzenes; Osteoblasts; Osteocalcin; Osteosarcoma; p38 Mitogen-Activated Protein Kinases; Pregnane X Receptor; Protein Kinase Inhibitors; Pyridines; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; RNA, Messenger; Sulfonamides; Vitamin K; Vitamins; Warfarin; Young Adult | 2010 |
Effects of florfenicol on LPS-induced nitric oxide and prostaglandin E₂ production in RAW 264.7 macrophages.
Topics: Animals; Anti-Bacterial Agents; Cell Line; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; Mice; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Thiamphenicol | 2011 |
Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-κB- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway.
Topics: Animals; Antibodies, Monoclonal; Ceramides; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Extremities; Hot Temperature; Hyperalgesia; Imidazoles; Injections; Male; Models, Biological; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pain Threshold; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiophenes; Touch | 2011 |
The aromatic volatile organic compounds toluene, benzene and styrene induce COX-2 and prostaglandins in human lung epithelial cells via oxidative stress and p38 MAPK activation.
Topics: Acetylcysteine; Air Pollutants; Benzene Derivatives; Blotting, Western; Cell Line; Cyclooxygenase 2; Dinoprost; Dinoprostone; Enzyme Activation; Enzyme Induction; Epithelial Cells; Glutathione; Humans; Imidazoles; Lung; MAP Kinase Kinase Kinases; Oxidative Stress; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Pyridines | 2011 |
Prostaglandin E2 enhances interleukin-8 production via EP4 receptor in human pulmonary microvascular endothelial cells.
Topics: Acute Lung Injury; Anthracenes; Butadienes; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Endothelial Cells; Humans; Imidazoles; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Lung; MAP Kinase Signaling System; Methyl Ethers; Microvessels; Naphthalenes; Neutrophils; Nitriles; p38 Mitogen-Activated Protein Kinases; Phenylbutyrates; Pyridines; Receptors, Prostaglandin E, EP4 Subtype; Respiratory Distress Syndrome; RNA, Messenger; Thionucleotides | 2012 |
Interaction between head and neck squamous cell carcinoma cells and fibroblasts in the biosynthesis of PGE2.
Topics: Arachidonic Acid; Carcinoma, Squamous Cell; Cell Movement; Cell Proliferation; Chemical Fractionation; Coculture Techniques; Culture Media, Conditioned; Cyclooxygenase 2; Dinoprostone; Fibroblasts; Head and Neck Neoplasms; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Interleukin-1; Intramolecular Oxidoreductases; Neovascularization, Pathologic; Prostaglandin-E Synthases; Prostaglandins F; Protein Array Analysis; Protein Stability; Pyridines; Receptors, Interleukin-1; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; Tumor Cells, Cultured | 2012 |
EGCG blocks TGFβ1-induced CCN2 by suppressing JNK and p38 in buccal fibroblasts.
Topics: Anthracenes; Benzamides; Catechin; Cell Line; Cells, Cultured; Connective Tissue Growth Factor; Dinoprostone; Dioxoles; Dose-Response Relationship, Drug; Fibroblasts; Flavonoids; Humans; Imidazoles; Lung; MAP Kinase Kinase 4; Mouth Mucosa; Oral Submucous Fibrosis; p38 Mitogen-Activated Protein Kinases; Protease Inhibitors; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2013 |
Effects of vascular endothelial cells on osteogenic differentiation of noncontact co-cultured periodontal ligament stem cells under hypoxia.
Topics: Adult; Alkaline Phosphatase; Animals; Calcification, Physiologic; Cell Culture Techniques; Cell Differentiation; Cell Hypoxia; Coculture Techniques; Core Binding Factor Alpha 1 Subunit; Dinoprostone; Endothelial Cells; Endothelium, Vascular; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Osteoblasts; Osteogenesis; p38 Mitogen-Activated Protein Kinases; Paracrine Communication; Periodontal Ligament; Pyridines; Sp7 Transcription Factor; Stem Cells; Transcription Factors; Vascular Endothelial Growth Factor A | 2013 |
p38/AP-1 pathway in lipopolysaccharide-induced inflammatory responses is negatively modulated by electrical stimulation.
Topics: Animals; Cell Line; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Electric Stimulation; Humans; Imidazoles; Inflammation; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Pyridines; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2013 |
Cyclic tensile force up-regulates BMP-2 expression through MAP kinase and COX-2/PGE2 signaling pathways in human periodontal ligament cells.
Topics: Adult; Bite Force; Bone Morphogenetic Protein 2; Butadienes; Calcification, Physiologic; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Humans; Imidazoles; Male; Mastication; Molar, Third; Nitriles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Stress, Physiological; Sulfonamides; Up-Regulation; Young Adult | 2014 |
Geniposide suppresses LPS-induced nitric oxide, PGE2 and inflammatory cytokine by downregulating NF-κB, MAPK and AP-1 signaling pathways in macrophages.
Topics: Animals; Anti-Inflammatory Agents; Butadienes; Cell Line; Cyclooxygenase 2; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Gardenia; Imidazoles; Inflammation Mediators; Interleukin-6; Iridoids; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred Strains; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Nitriles; Pyridines; Signal Transduction; Sulfones; Transcription Factor AP-1; Tumor Necrosis Factor-alpha | 2014 |
Cyclooxygenase 2-mediated apoptotic and inflammatory responses in photodynamic therapy treated breast adenocarcinoma cells and xenografts.
Topics: Acetylcysteine; Adenocarcinoma; Animals; Apoptosis; Breast Neoplasms; Cyclooxygenase 2; Dinoprostone; Female; Humans; Imidazoles; Interleukin-1beta; Light; MCF-7 Cells; Mice; Mice, Inbred BALB C; Photosensitizing Agents; Pyridines; Reactive Oxygen Species; Signal Transduction; Transplantation, Heterologous; Tumor Necrosis Factor-alpha | 2014 |
Helicobacter pylori promotes VEGF expression via the p38 MAPK‑mediated COX‑2‑PGE2 pathway in MKN45 cells.
Topics: Cell Line, Tumor; Cyclooxygenase 2; Dinoprostone; HEK293 Cells; Helicobacter pylori; Humans; Imidazoles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; RNA Interference; RNA, Small Interfering; Sulfonamides; Up-Regulation; Vascular Endothelial Growth Factor A | 2014 |
Regulation by resveratrol of prostaglandin E2-stimulated osteoprotegerin synthesis in osteoblasts.
Topics: 3T3 Cells; Animals; Anthracenes; Dinoprostone; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinase 1; Osteoblasts; Osteoprotegerin; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Resveratrol; Sirtuin 1; Stilbenes | 2014 |
DJ-1 mutation decreases astroglial release of inflammatory mediators.
Topics: Animals; Anthracenes; Astrocytes; Butadienes; Cyclooxygenase 2; Dinoprostone; Imidazoles; Inflammation Mediators; Lipopolysaccharides; Mice; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type II; Nitriles; Primary Cell Culture; Protein Deglycase DJ-1; Pyridines; Tumor Necrosis Factor-alpha | 2016 |
Hippocampal CA1 βCaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression.
Topics: Adenoviridae; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cyclooxygenase 2; Cytokines; Depression; Dinoprostone; Disease Models, Animal; Food Preferences; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hippocampus; Imidazoles; Lipopolysaccharides; Male; Pyridines; Rats; Rats, Sprague-Dawley; RNA Interference; Stress, Psychological; Swimming | 2018 |
Cellular Microenvironment Stiffness Regulates Eicosanoid Production and Signaling Pathways.
Topics: Cellular Microenvironment; Cyclooxygenase 2; Dinoprostone; Fibroblasts; Humans; Idiopathic Pulmonary Fibrosis; Imidazoles; Lung; Prostaglandin-E Synthases; Pyridines; Signal Transduction | 2020 |