Protein | Taxonomy | sb 203580 (IC50) | cilomilast (IC50) |
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | | 0.018 |
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | | 0.018 |
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | | 0.018 |
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | | 0.018 |
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | | 0.018 |
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | | 0.018 |
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | | 0.018 |
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | | 0.018 |
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | | 0.018 |
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | | 0.018 |
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | | 0.018 |
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | | 0.018 |
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | | 0.018 |
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | | 0.018 |
cGMP-dependent 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | | 2.3453 |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A | Homo sapiens (human) | | 2.3453 |
cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | | 2.3453 |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Rattus norvegicus (Norway rat) | | 0.113 |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C | Rattus norvegicus (Norway rat) | | 0.113 |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Rattus norvegicus (Norway rat) | | 0.1623 |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Homo sapiens (human) | | 0.3113 |
Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | | 0.062 |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Rattus norvegicus (Norway rat) | | 0.113 |
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Homo sapiens (human) | | 2.3453 |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | | 0.4623 |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C | Homo sapiens (human) | | 0.818 |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | | 0.4642 |
cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Homo sapiens (human) | | 4.259 |
cGMP-inhibited 3',5'-cyclic phosphodiesterase A | Homo sapiens (human) | | 10 |
Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | | 0.12 |
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | Homo sapiens (human) | | 2.3453 |
cAMP-specific 3',5'-cyclic phosphodiesterase 7B | Homo sapiens (human) | | 2.3453 |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | Homo sapiens (human) | | 2.3453 |
Article | Year |
In silico search for multi-target anti-inflammatories in Chinese herbs and formulas.Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6
Topics: Anti-Inflammatory Agents; Crystallography, X-Ray; Cyclooxygenase 1; Cyclooxygenase 2; Databases, Factual; Drug Design; Drugs, Chinese Herbal; Enzyme Inhibitors; JNK Mitogen-Activated Protein Kinases; Medicine, Chinese Traditional; Models, Chemical; Models, Molecular; Molecular Conformation; p38 Mitogen-Activated Protein Kinases; Phosphodiesterase 4 Inhibitors; Structure-Activity Relationship | 2010 |
Role of PDE4 in superoxide anion generation through p44/42MAPK regulation: a cAMP and a PKA-independent mechanism.British journal of pharmacology, 2004, Volume: 143, Issue:2
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Bronchoalveolar Lavage Fluid; Bucladesine; CREB-Binding Protein; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclohexanecarboxylic Acids; Flavonoids; Gene Expression Regulation, Enzymologic; Imidazoles; Lipopolysaccharides; Macrophages; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitriles; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-raf; Pyridines; Rats; Rats, Wistar; Reactive Oxygen Species; Rolipram; Superoxides; Trans-Activators | 2004 |