sb 203580 has been researched along with arachidonic acid in 27 studies
| Studies (sb 203580) | Trials (sb 203580) | Recent Studies (post-2010) (sb 203580) | Studies (arachidonic acid) | Trials (arachidonic acid) | Recent Studies (post-2010) (arachidonic acid) |
|---|---|---|---|---|---|
| 3,489 | 4 | 1,137 | 19,295 | 486 | 3,040 |
| Protein | Taxonomy | sb 203580 (IC50) | arachidonic acid (IC50) |
|---|---|---|---|
| 60 kDa heat shock protein, mitochondrial | Homo sapiens (human) | 4.5 | |
| Fatty acid-binding protein, adipocyte | Homo sapiens (human) | 2.75 | |
| 10 kDa heat shock protein, mitochondrial | Homo sapiens (human) | 4.5 | |
| 60 kDa chaperonin | Escherichia coli | 7.3 | |
| 10 kDa chaperonin | Escherichia coli | 7.3 | |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | 1.0715 | |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | 0.6026 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (25.93) | 18.2507 |
| 2000's | 17 (62.96) | 29.6817 |
| 2010's | 3 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adams, JL; Badger, AM; Bradbeer, JN; Griswold, DE; Lee, JC; Votta, B | 1 |
| Barbosa, MS; Belardetti, F; Cobb, MH; Stein, B; Wilk-Blaszczak, MA; Xu, S | 1 |
| Börsch-Haubold, AG; Pasquet, S; Watson, SP | 1 |
| Hajjar, JJ; Molski, TF; Nagarkatti, D; Sha'afi, RI; Syrbu, SI; Waterman, WH | 1 |
| Abdel-Latif, AA; Husain, S | 1 |
| Börsch-Haubold, AG; Cohen, P; Gelb, MH; Ghomashchi, F; Goedert, M; Pasquet, S; Watson, SP | 1 |
| Bilney, A; Ferrante, A; Hii, CS; Huang, ZH; Murray, AW; Rathjen, DA; Stacey, K | 1 |
| Akkerman, JW; Bos, JL; Franke, B; Gorter, G; Hackeng, CM; Relou, IA; van Rijn , HJ | 1 |
| Barnes, PJ; Cambridge, L; Hart, LA; Lindsay, MA; Newton, R; Stevens, DA | 1 |
| Gonzalez, A; Schmid, A; Schulz, I; Siegel, G; Sternfeld, L | 1 |
| Linch, DC; Mollapour, E; Roberts, PJ | 1 |
| Houliston, RA; Pearson, JD; Wheeler-Jones, CP | 1 |
| Klemm, J; Rådmark, O; Samuelsson, B; Werz, O | 1 |
| Cederbaum, AI; Wu, D | 1 |
| Huang, XL; Lawrence, M; Madara, P; Nanavaty, UB; Pawliczak, R; Shelhamer, JH | 1 |
| Berenbaum, F; Bereziat, G; Humbert, L; Thirion, S | 1 |
| Avila, J; Díaz-Nido, J; Gómez-Ramos, A; Perry, G; Smith, MA | 1 |
| Rao, GN; Yellaturu, CR | 1 |
| Han, C; Shelhamer, JH; Wu, T | 1 |
| Balduini, C; Canobbio, I; Reineri, S; Sinigaglia, F; Torti, M | 1 |
| Alberghina, M; Anfuso, CD; Giurdanella, G; Lupo, G; Marchetti, B; Nicotra, A; Ragusa, N; Tirolo, C | 1 |
| Kawakami, T; Olsson, T; Yucel-Lindberg, T | 1 |
| Bavec, A; Corda, D; Di Girolamo, M; Mariggiò, S; Natale, E; Salmona, M; Zizza, P | 1 |
| Han, HJ; Lee, MY; Lee, SH | 1 |
| Feisst, C; Glaubitz, C; Hoffmann, M; Jakobsson, PJ; Lopez, JJ; Pawelczik, S; Pergola, C; Sorg, BL; Steinhilber, D; Werz, O | 1 |
| Giacobbe, E; Leoncini, G; Signorello, MG | 1 |
| Alcolea, S; Alfranca, A; Antón, R; Avilés-Jurado, FX; Camacho, M; León, X; Quer, M; Redondo, JM; Soler, M; Vila, L | 1 |
27 other study(ies) available for sb 203580 and arachidonic acid
| Article | Year |
|---|---|
Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function.
Topics: Animals; Arachidonic Acid; Arthritis; Bone Resorption; Calcium-Calmodulin-Dependent Protein Kinases; Collagen; Disease Models, Animal; Enzyme Inhibitors; Female; Imidazoles; Male; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Inbred Lew; Shock, Septic; Tumor Necrosis Factor-alpha | 1996 |
The mitogen-activated protein kinase p38-2 is necessary for the inhibition of N-type calcium current by bradykinin.
Topics: Animals; Arachidonic Acid; Bradykinin; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Extracellular Space; Glioma; GTP-Binding Proteins; Hybrid Cells; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Nerve Tissue Proteins; Neuroblastoma; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Signal Transduction | 1998 |
Direct inhibition of cyclooxygenase-1 and -2 by the kinase inhibitors SB 203580 and PD 98059. SB 203580 also inhibits thromboxane synthase.
Topics: Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Flavonoids; Humans; Imidazoles; In Vitro Techniques; Isoenzymes; Membrane Proteins; Platelet Activation; Prostaglandin H2; Prostaglandin-Endoperoxide Synthases; Prostaglandins H; Pyridines; Thromboxane A2; Thromboxane-A Synthase | 1998 |
Phosphorylation of cytosolic phospholipase A2 and the release of arachidonic acid in human neutrophils.
Topics: Acyltransferases; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cytosol; Flavonoids; Humans; Imidazoles; Lipopolysaccharides; Microsomes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activating Factor; Protein Kinase C; Pyridines; Tumor Necrosis Factor-alpha; Tyrosine | 1999 |
Endothelin-1 activates p38 mitogen-activated protein kinase and cytosolic phospholipase A2 in cat iris sphincter smooth muscle cells.
Topics: Animals; Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cats; Cells, Cultured; Cyclic AMP; Cytosol; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Activation; Flavonoids; GTP-Binding Proteins; Imidazoles; Indoles; Intercellular Signaling Peptides and Proteins; Iris; Mitogen-Activated Protein Kinases; Muscle, Smooth; p38 Mitogen-Activated Protein Kinases; Peptides; Pertussis Toxin; Phospholipases A; Phospholipases A2; Phosphorylation; Pyridines; Receptors, Endothelin; Virulence Factors, Bordetella; Wasp Venoms | 1999 |
Phosphorylation of cytosolic phospholipase A2 in platelets is mediated by multiple stress-activated protein kinase pathways.
Topics: Arachidonic Acid; Blood Platelets; Collagen; Cytosol; Enzyme Activation; Enzyme Inhibitors; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 12; Mitogen-Activated Protein Kinase 13; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Platelet Activation; Protein Isoforms; Pyridines; Thrombin | 1999 |
Involvement of protein kinase C, p38 MAP kinase and ERK in arachidonic acid-stimulated superoxide production in human neutrophils.
Topics: Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; In Vitro Techniques; Indoles; Kinetics; Maleimides; Mitogen-Activated Protein Kinases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Pyridines; Superoxides | 1999 |
Low-density lipoprotein activates the small GTPases Rap1 and Ral in human platelets.
Topics: Arachidonic Acid; Blood Platelet Disorders; Blood Platelets; Collagen; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Glutathione Transferase; Humans; Imidazoles; Indomethacin; Ligands; Lipoproteins, LDL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Pyridines; ral GTP-Binding Proteins; rap1 GTP-Binding Proteins; Recombinant Fusion Proteins; Signal Transduction; Thrombin; Thromboxane A2; Time Factors | 2000 |
The MAP kinase inhibitors, PD098059, UO126 and SB203580, inhibit IL-1beta-dependent PGE(2) release via mechanistically distinct processes.
Topics: Arachidonic Acid; Butadienes; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Interleukin-1; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; Time Factors; Tumor Cells, Cultured | 2000 |
Arachidonic acid modulates the spatiotemporal characteristics of agonist-evoked Ca2+ waves in mouse pancreatic acinar cells.
Topics: Acetylcholine; Animals; Arachidonic Acid; Arachidonic Acids; Bombesin; Calcium Signaling; Cells, Cultured; Cholecystokinin; Enzyme Inhibitors; Flavonoids; Imidazoles; Indomethacin; Kinetics; Male; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pancreas; Phosphorylation; Pyridines | 2001 |
Activation and priming of neutrophil nicotinamide adenine dinucleotide phosphate oxidase and phospholipase A(2) are dissociated by inhibitors of the kinases p42(ERK2) and p38(SAPK) and by methyl arachidonyl fluorophosphonate, the dual inhibitor of cytosol
Topics: Arachidonic Acid; Arachidonic Acids; Calcimycin; Complement C5a; Cytosol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Granulocyte-Macrophage Colony-Stimulating Factor; Group VI Phospholipases A2; Humans; Imidazoles; Ionophores; Isoenzymes; MAP Kinase Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Organophosphonates; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Protein Serine-Threonine Kinases; Pyridines; Respiratory Burst; Superoxides; Tumor Necrosis Factor-alpha | 2001 |
Agonist-specific cross talk between ERKs and p38(mapk) regulates PGI(2) synthesis in endothelium.
Topics: Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Epoprostenol; Group IV Phospholipases A2; Hemostatics; Humans; Imidazoles; Interleukin-1; MAP Kinase Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Pyridines; Receptor Cross-Talk; Thrombin; Umbilical Veins | 2001 |
p38 MAP kinase mediates stress-induced leukotriene synthesis in a human B-lymphocyte cell line.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arsenites; B-Lymphocytes; Calcimycin; Calcium; Cell Line; Cell-Free System; Enzyme Activation; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Hypertonic Solutions; Imidazoles; Interleukin-1; Intracellular Signaling Peptides and Proteins; Ionophores; Leukotrienes; Lipoxygenase Inhibitors; Mitogen-Activated Protein Kinases; Osmotic Pressure; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinases; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Pyridines; Sodium Compounds; Sorbitol; Subcellular Fractions; Thapsigargin; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Vanadates | 2001 |
Role of p38 MAPK in CYP2E1-dependent arachidonic acid toxicity.
Topics: Animals; Antioxidants; Arachidonic Acid; Cell Line; Cytochrome P-450 CYP2E1; DNA; Flavonoids; Hepatocytes; Humans; Imidazoles; Male; Metalloendopeptidases; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Salicylates | 2003 |
Oxidative stress induces arachidonate release from human lung cells through the epithelial growth factor receptor pathway.
Topics: Antineoplastic Agents; Arachidonic Acid; Calcium; Cells, Cultured; Cytosol; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Hydrogen Peroxide; Imidazoles; Ionophores; Lung; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oxidants; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Platelet Activating Factor; Protein Serine-Threonine Kinases; Pyridines; Quinazolines; ras Proteins; RNA, Messenger; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins | 2002 |
Concomitant recruitment of ERK1/2 and p38 MAPK signalling pathway is required for activation of cytoplasmic phospholipase A2 via ATP in articular chondrocytes.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Biological Transport; Blotting, Western; Cartilage, Articular; Chondrocytes; Cytoplasm; Dinoprostone; DNA, Complementary; Dose-Response Relationship, Drug; Electrophoresis; Enzyme Activation; Female; Flavonoids; Genes, Dominant; Imidazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Polymerase Chain Reaction; Pyridines; Rabbits; Signal Transduction; Time Factors | 2003 |
Effect of the lipid peroxidation product acrolein on tau phosphorylation in neural cells.
Topics: Acrolein; Animals; Arachidonic Acid; Blotting, Western; Cerebral Cortex; Enzyme Inhibitors; Humans; Imidazoles; Lipid Peroxidation; Lithium; Mice; Mitogen-Activated Protein Kinases; Neuroblastoma; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; tau Proteins; Tumor Cells, Cultured | 2003 |
A requirement for calcium-independent phospholipase A2 in thrombin-induced arachidonic acid release and growth in vascular smooth muscle cells.
Topics: Animals; Arachidonic Acid; Blotting, Western; Coloring Agents; DNA; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Group VI Phospholipases A2; Imidazoles; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Naphthalenes; Oleic Acid; Oligonucleotides, Antisense; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Pyridines; Pyrones; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetrazolium Salts; Thiazoles; Thrombin; Time Factors | 2003 |
Involvement of p38 and p42/44 MAP kinases and protein kinase C in the interferon-gamma and interleukin-1alpha-induced phosphorylation of 85-kDa cytosolic phospholipase A(2) in primary human bronchial epithelial cells.
Topics: Arachidonic Acid; Arachidonic Acids; Bronchi; Cells, Cultured; Cytosol; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; Imidazoles; Interferon-gamma; Interleukin-1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Naphthalenes; Organophosphonates; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Protein Kinase C; Pyridines; Pyrones | 2004 |
A role for p38 MAP kinase in platelet activation by von Willebrand factor.
Topics: Antibodies, Monoclonal; Antigens, CD; Arachidonic Acid; Blood Platelets; Cyclooxygenase Inhibitors; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Precursors; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activation; Platelet Glycoprotein GPIb-IX Complex; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Protein-Tyrosine Kinases; Pyridines; Receptors, IgG; Ristocetin; Signal Transduction; Syk Kinase; Thromboxane A2; Time Factors; von Willebrand Factor | 2004 |
MAPKs mediate the activation of cytosolic phospholipase A2 by amyloid beta(25-35) peptide in bovine retina pericytes.
Topics: Amyloid beta-Peptides; Animals; Arachidonic Acid; Biological Transport; Cattle; Cell Nucleus; Cytosol; Enzyme Activation; Flavonoids; Imidazoles; Microscopy, Confocal; Mitogen-Activated Protein Kinases; Pericytes; Phospholipases A; Phospholipases A2; Phosphorylation; Pyridines; Retina; RNA, Messenger | 2005 |
Signal pathways involved in the regulation of prostaglandin E synthase-1 in human gingival fibroblasts.
Topics: Arachidonic Acid; Blotting, Western; Cells, Cultured; Child; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression Regulation; Gingiva; Humans; Imidazoles; Indoles; Interleukin-1beta; Intramolecular Oxidoreductases; Maleimides; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Prostaglandin D2; Prostaglandin-E Synthases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha | 2006 |
Galpha13 mediates activation of the cytosolic phospholipase A2alpha through fine regulation of ERK phosphorylation.
Topics: Animals; Arachidonic Acid; Butadienes; CHO Cells; Cricetinae; Cricetulus; Cytosol; Enzyme Activation; Enzyme Inhibitors; Group IV Phospholipases A2; GTP-Binding Protein alpha Subunits, G12-G13; Imidazoles; Marine Toxins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutation; Nitriles; Oxazoles; Phospholipases A; Phosphoric Monoester Hydrolases; Phosphorylation; Pyridines; Pyrrolidines; rhoA GTP-Binding Protein; Transfection | 2006 |
Short-period hypoxia increases mouse embryonic stem cell proliferation through cooperation of arachidonic acid and PI3K/Akt signalling pathways.
Topics: Animals; Arachidonic Acid; Ascorbic Acid; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Chromones; Cyclin D1; Cyclin E; Cyclin-Dependent Kinases; Embryonic Stem Cells; Flavonoids; G1 Phase; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phospholipases A2, Cytosolic; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Up-Regulation | 2008 |
Hyperforin induces Ca(2+)-independent arachidonic acid release in human platelets by facilitating cytosolic phospholipase A(2) activation through select phospholipid interactions.
Topics: Arachidonic Acid; Blood Platelets; Bridged Bicyclo Compounds; Calcium; Cytosol; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Magnetic Resonance Spectroscopy; p38 Mitogen-Activated Protein Kinases; Phloroglucinol; Phosphatidylcholines; Phospholipases A2; Phosphorylation; Pyridines; Terpenes | 2010 |
Activation by 2-arachidonoylglycerol of platelet p38MAPK/cPLA2 pathway.
Topics: Apyrase; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Endocannabinoids; Glycerides; Humans; Imidazoles; In Vitro Techniques; Indomethacin; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Phospholipases A2, Cytosolic; Phosphorylation; Piperidines; Pyrazoles; Pyridines; Reactive Oxygen Species; Rimonabant; Signal Transduction | 2011 |
Interaction between head and neck squamous cell carcinoma cells and fibroblasts in the biosynthesis of PGE2.
Topics: Arachidonic Acid; Carcinoma, Squamous Cell; Cell Movement; Cell Proliferation; Chemical Fractionation; Coculture Techniques; Culture Media, Conditioned; Cyclooxygenase 2; Dinoprostone; Fibroblasts; Head and Neck Neoplasms; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Interleukin-1; Intramolecular Oxidoreductases; Neovascularization, Pathologic; Prostaglandin-E Synthases; Prostaglandins F; Protein Array Analysis; Protein Stability; Pyridines; Receptors, Interleukin-1; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; Tumor Cells, Cultured | 2012 |