Compounds > sb 203580
Page last updated: 2024-09-05

sb 203580 and apigenin

sb 203580 has been researched along with apigenin in 6 studies

Compound Research Comparison

Studies
(sb 203580)		Trials
(sb 203580)		Recent Studies (post-2010)
(sb 203580)		Studies
(apigenin)		Trials
(apigenin)		Recent Studies (post-2010) (apigenin)
3,48941,1373,273752,086

Protein Interaction Comparison

ProteinTaxonomysb 203580 (IC50)apigenin (IC50)
Chain A, Casein kinase II subunit alphaZea mays1.2
Chain A, Casein kinase II subunit alphaZea mays1.2
Chain A, Casein Kinase Ii Subunit AlphaZea mays1.2
Aldo-keto reductase family 1 member B10Homo sapiens (human)6.6
G2/mitotic-specific cyclin-B2Homo sapiens (human)4
Poly [ADP-ribose] polymerase tankyrase-1Homo sapiens (human)3.1311
Estrogen receptorHomo sapiens (human)1.253
Cytochrome P450 1A1Homo sapiens (human)0.427
MyeloperoxidaseHomo sapiens (human)3.8
Cytochrome P450 1A2Homo sapiens (human)0.795
Cyclin-dependent kinase 1Homo sapiens (human)4
Beta-glucuronidaseRattus norvegicus (Norway rat)2.8
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)6.67
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 23.02
Androgen receptorHomo sapiens (human)5.2
Serine/threonine-protein kinase pim-1Homo sapiens (human)0.94
AromataseHomo sapiens (human)3.275
17-beta-hydroxysteroid dehydrogenase type 1Homo sapiens (human)0.71
Pyruvate kinase PKMHomo sapiens (human)0.99
G2/mitotic-specific cyclin-B1Homo sapiens (human)4
G2/mitotic-specific cyclin-BMarthasterias glacialis (spiny starfish)2.175
Glycogen synthase kinase-3 betaRattus norvegicus (Norway rat)2.175
Casein kinase II subunit alpha'Homo sapiens (human)0.85
Amine oxidase [flavin-containing] AHomo sapiens (human)1.398
Amine oxidase [flavin-containing] BHomo sapiens (human)1.12
Dipeptidyl peptidase 4Homo sapiens (human)0.14
Proteasome subunit beta type-5Homo sapiens (human)1.4
Prostaglandin G/H synthase 2Homo sapiens (human)8
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)1.45
Tyrosine-protein kinase SYKHomo sapiens (human)4.2
Xanthine dehydrogenase/oxidaseHomo sapiens (human)1.95
Glycogen synthase kinase-3 alphaHomo sapiens (human)1.4
Glycogen synthase kinase-3 betaHomo sapiens (human)1.4
Mitogen-activated protein kinase 10Homo sapiens (human)2.2
Casein kinase II subunit betaHomo sapiens (human)0.85
Casein kinase II subunit alphaHomo sapiens (human)0.84
Xanthine dehydrogenase/oxidaseBos taurus (cattle)3.57
MO15-related protein kinase Pfmrk Plasmodium falciparum (malaria parasite P. falciparum)7
Cyclin-dependent kinase 6Homo sapiens (human)2.08
Cyclin-dependent-like kinase 5 Homo sapiens (human)2.06
Cyclin homologHerpesvirus saimiri (strain 11)2.175
Cyclin-dependent kinase 5 activator 1Homo sapiens (human)2.06
Mitogen-activated protein kinase 14Homo sapiens (human)2.2
Cytochrome P450 1B1Homo sapiens (human)0.1925
Integrase Human immunodeficiency virus 11.5
Casein kinase II subunit alpha 3Homo sapiens (human)0.8
G2/mitotic-specific cyclin-B3Homo sapiens (human)4
Estrogen receptor betaHomo sapiens (human)0.13
Aurora kinase BHomo sapiens (human)3.96
NACHT, LRR and PYD domains-containing protein 3 Homo sapiens (human)10
Cyclin-dependent kinase 1Oryzias latipes (Japanese medaka)2.175
Poly [ADP-ribose] polymerase tankyrase-2Homo sapiens (human)2.9256
MAP kinase-interacting serine/threonine-protein kinase 2Homo sapiens (human)0.308
NADPH oxidase 4Homo sapiens (human)1.13
Inositol hexakisphosphate kinase 2Homo sapiens (human)7.1
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)4.5

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (66.67)29.6817
2010's1 (16.67)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H1
Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M1
Klein, JP; Neff, L; Schöller-Guinard, M; Sibilia, J; Wachsmann, D; Zeisel, M1
Chen, YH; Hsieh, HC; Hsueh, CH; Liu, YH; Tsai, PJ; Tsou, CC; Wu, JJ1
Bhonde, RR; Dadheech, N; Dave, A; Gupta, S; Paranjape, N; Shah, GM; Srivastava, A1
Chen, HL; Han, H; Jia, WJ; Li, F; Li, HE; Li, JJ; Wu, CY; Yuan, Y; Zhang, XL1

Other Studies

6 other study(ies) available for sb 203580 and apigenin

ArticleYear
Identifying off-target effects and hidden phenotypes of drugs in human cells.
    Nature chemical biology, 2006, Volume: 2, Issue:6

    Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

2006
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-18, Volume: 104, Issue:51

    Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

2007
NF-kappaB and the MAP kinases/AP-1 pathways are both involved in interleukin-6 and interleukin-8 expression in fibroblast-like synoviocytes stimulated by protein I/II, a modulin from oral streptococci.
    Cellular microbiology, 2001, Volume: 3, Issue:10

    Topics: Anti-Bacterial Agents; Apigenin; Arthritis, Rheumatoid; Bacterial Proteins; Cells, Cultured; Curcumin; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Interleukin-6; Interleukin-8; MAP Kinase Signaling System; Membrane Glycoproteins; NF-kappa B; Pyridines; Signal Transduction; Streptococcus; Sulfasalazine; Synovial Membrane

2001
Streptococcus pyogenes induces epithelial inflammatory responses through NF-kappaB/MAPK signaling pathways.
    Microbes and infection, 2006, Volume: 8, Issue:6

    Topics: Apigenin; Autoantibodies; Cell Movement; Chemotaxis; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Humans; Imidazoles; Interleukin-6; Interleukin-8; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; NF-kappa B; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Streptococcal Infections; Streptococcus pyogenes; Transcription Factor AP-1; U937 Cells

2006
Swertisin an Anti-Diabetic Compound Facilitate Islet Neogenesis from Pancreatic Stem/Progenitor Cells via p-38 MAP Kinase-SMAD Pathway: An In-Vitro and In-Vivo Study.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Animals; Apigenin; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Cells, Cultured; Down-Regulation; Homeodomain Proteins; Humans; Hypoglycemic Agents; Imidazoles; Islets of Langerhans; Male; Mice; Mice, Inbred BALB C; Nerve Tissue Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Signal Transduction; Smad Proteins; Stem Cells; Trans-Activators; Transcriptional Activation

2015
Scutellarin Exerts Anti-Inflammatory Effects in Activated Microglia/Brain Macrophage in Cerebral Ischemia and in Activated BV-2 Microglia Through Regulation of MAPKs Signaling Pathway.
    Neuromolecular medicine, 2020, Volume: 22, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apigenin; Cerebral Cortex; Gene Expression Regulation; Glucuronates; Imidazoles; Infarction, Middle Cerebral Artery; Inflammation Mediators; Macrophage Activation; Male; MAP Kinase Signaling System; Mice; Microglia; Nerve Tissue Proteins; Nitric Oxide Synthase Type II; Protein Kinases; Pyridines; Random Allocation; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha

2020