sb 203580 has been researched along with alvocidib in 7 studies
| Studies (sb 203580) | Trials (sb 203580) | Recent Studies (post-2010) (sb 203580) | Studies (alvocidib) | Trials (alvocidib) | Recent Studies (post-2010) (alvocidib) |
|---|---|---|---|---|---|
| 3,489 | 4 | 1,137 | 627 | 66 | 204 |
| Protein | Taxonomy | sb 203580 (IC50) | alvocidib (IC50) |
|---|---|---|---|
| Chain A, Protein (glycogen Phosphorylase) | Oryctolagus cuniculus (rabbit) | 1 | |
| Glycogen synthase kinase-3 beta | Sus scrofa (pig) | 0.36 | |
| [Tau protein] kinase | Sus scrofa (pig) | 0.36 | |
| Cyclin-T1 | Homo sapiens (human) | 0.0243 | |
| Cyclin-K | Homo sapiens (human) | 1.37 | |
| Serine/threonine-protein kinase D3 | Homo sapiens (human) | 8 | |
| G2/mitotic-specific cyclin-B2 | Homo sapiens (human) | 0.1571 | |
| G1/S-specific cyclin-E2 | Homo sapiens (human) | 0.36 | |
| Glycogen phosphorylase, muscle form | Oryctolagus cuniculus (rabbit) | 1.2 | |
| Epidermal growth factor receptor | Homo sapiens (human) | 7.6 | |
| Vitamin K-dependent protein C | Homo sapiens (human) | 0.1429 | |
| Protein kinase C gamma type | Homo sapiens (human) | 8 | |
| Protein kinase C beta type | Homo sapiens (human) | 8 | |
| Tyrosine-protein kinase Lck | Homo sapiens (human) | 0.4 | |
| Cyclin-dependent kinase 1 | Homo sapiens (human) | 0.1159 | |
| Cyclin-dependent kinase 4 | Homo sapiens (human) | 0.1589 | |
| G2/mitotic-specific cyclin-B1 | Homo sapiens (human) | 0.1464 | |
| G2/mitotic-specific cyclin-B | Marthasterias glacialis (spiny starfish) | 0.2067 | |
| Protein kinase C alpha type | Homo sapiens (human) | 6.2667 | |
| Glycogen synthase kinase-3 beta | Rattus norvegicus (Norway rat) | 0.185 | |
| Cyclin-A2 | Homo sapiens (human) | 0.3441 | |
| Dual specificity protein kinase CLK1 | Mus musculus (house mouse) | 1.3 | |
| G1/S-specific cyclin-D1 | Homo sapiens (human) | 0.1837 | |
| Protein kinase C eta type | Homo sapiens (human) | 8 | |
| G1/S-specific cyclin-E1 | Homo sapiens (human) | 0.2249 | |
| Cyclin-dependent kinase 2 | Homo sapiens (human) | 0.2367 | |
| G1/S-specific cyclin-D2 | Homo sapiens (human) | 0.1 | |
| G1/S-specific cyclin-D3 | Homo sapiens (human) | 0.1983 | |
| Vascular endothelial growth factor receptor 2 | Homo sapiens (human) | 0.4 | |
| Protein kinase C iota type | Homo sapiens (human) | 8 | |
| Glycogen synthase kinase-3 alpha | Homo sapiens (human) | 0.525 | |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | 0.6517 | |
| Cyclin-dependent kinase 7 | Homo sapiens (human) | 0.3365 | |
| Cyclin-dependent kinase 9 | Homo sapiens (human) | 0.0209 | |
| Cyclin-H | Homo sapiens (human) | 0.3413 | |
| CDK-activating kinase assembly factor MAT1 | Homo sapiens (human) | 0.514 | |
| Cyclin-A1 | Homo sapiens (human) | 0.785 | |
| Cyclin-dependent kinase 6 | Homo sapiens (human) | 0.1572 | |
| Cyclin-dependent-like kinase 5 | Homo sapiens (human) | 0.1747 | |
| Cyclin homolog | Herpesvirus saimiri (strain 11) | 0.185 | |
| Protein kinase C epsilon type | Homo sapiens (human) | 5.4933 | |
| Protein kinase C theta type | Homo sapiens (human) | 8 | |
| Protein kinase C zeta type | Homo sapiens (human) | 8 | |
| Protein kinase C delta type | Homo sapiens (human) | 5.63 | |
| Cyclin-dependent kinase 5 activator 1 | Homo sapiens (human) | 0.1765 | |
| Serine/threonine-protein kinase D1 | Homo sapiens (human) | 8 | |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Rattus norvegicus (Norway rat) | 0.3 | |
| G2/mitotic-specific cyclin-B3 | Homo sapiens (human) | 0.1571 | |
| Cyclin-dependent kinase 1 | Oryzias latipes (Japanese medaka) | 0.2067 | |
| Cyclin-dependent kinase 12 | Homo sapiens (human) | 1.37 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Atteridge, CE; Azimioara, MD; Benedetti, MG; Biggs, WH; Carter, TA; Ciceri, P; Edeen, PT; Fabian, MA; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lélias, JM; Lockhart, DJ; Mehta, SA; Milanov, ZV; Patel, HK; Treiber, DK; Velasco, AM; Wodicka, LM; Zarrinkar, PP | 1 |
| Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Gallant, P; Herrgard, S; Hunt, JP; Karaman, MW; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Treiber, DK; Wodicka, LM; Zarrinkar, PP | 1 |
| Russu, WA; Shallal, HM | 1 |
| Ciceri, P; Davis, MI; Herrgard, S; Hocker, M; Hunt, JP; Pallares, G; Treiber, DK; Wodicka, LM; Zarrinkar, PP | 1 |
| Bharate, SB; Raghuvanshi, R | 1 |
| Caballero, E; García-Cárceles, J; Gil, C; Martínez, A | 1 |
| Coffey, ET; Courtney, MJ | 1 |
1 review(s) available for sb 203580 and alvocidib
| Article | Year |
|---|---|
Kinase Inhibitors as Underexplored Antiviral Agents.
Topics: Animals; Antiviral Agents; Drug Repositioning; Humans; Protein Kinase Inhibitors; Virus Diseases; Viruses | 2022 |
6 other study(ies) available for sb 203580 and alvocidib
| Article | Year |
|---|---|
A small molecule-kinase interaction map for clinical kinase inhibitors.
Topics: Benzamides; Drug Design; Escherichia coli; Escherichia coli Proteins; Imatinib Mesylate; Microchemistry; Pharmaceutical Preparations; Piperazines; Protein Binding; Protein Interaction Mapping; Protein Kinase Inhibitors; Pyrimidines | 2005 |
A quantitative analysis of kinase inhibitor selectivity.
Topics: Binding Sites; Enzyme Activation; Humans; Phosphotransferases; Protein Binding; Protein Interaction Mapping; Protein Kinase Inhibitors; Proteome; Quantitative Structure-Activity Relationship | 2008 |
Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Pyrimidines; Stereoisomerism; Structure-Activity Relationship | 2011 |
Comprehensive analysis of kinase inhibitor selectivity.
Topics: Catalysis; Drug Design; Enzyme Stability; High-Throughput Screening Assays; Humans; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Proteomics; Signal Transduction; Substrate Specificity | 2011 |
Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections.
Topics: Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Drug Approval; Drug Repositioning; High-Throughput Screening Assays; Humans; Protein Kinase Inhibitors; SARS-CoV-2; United States; United States Food and Drug Administration; Virus Diseases | 2022 |
The mechanism of Ara-C-induced apoptosis of differentiating cerebellar granule neurons.
Topics: Androstadienes; Animals; Antimetabolites, Antineoplastic; Apoptosis; Benzamides; CDC2 Protein Kinase; CDC2-CDC28 Kinases; Cell Differentiation; Cell Survival; Cerebellum; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Cytarabine; Enzyme Inhibitors; Flavonoids; Imatinib Mesylate; Imidazoles; Mitogen-Activated Protein Kinase 12; Mitogen-Activated Protein Kinases; Neurons; Piperazines; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Kinases; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Purines; Pyridines; Pyrimidines; Rats; Roscovitine; Signal Transduction; Stress, Physiological; Wortmannin | 1999 |