sb 203580 has been researched along with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide in 15 studies
| Studies (sb 203580) | Trials (sb 203580) | Recent Studies (post-2010) (sb 203580) | Studies (4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide) | Trials (4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide) | Recent Studies (post-2010) (4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide) |
|---|---|---|---|---|---|
| 3,489 | 4 | 1,137 | 552 | 0 | 406 |
| Protein | Taxonomy | sb 203580 (IC50) | 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide (IC50) |
|---|---|---|---|
| TGF-beta receptor type-1 | Homo sapiens (human) | 0.2587 | |
| TGF-beta receptor type-2 | Homo sapiens (human) | 0.066 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 11 (73.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Burgess, JL; Callahan, JF; Fornwald, JA; Gaster, LM; Harling, JD; Harrington, FP; Heer, J; Kwon, C; Laping, NJ; Lehr, R; Mathur, A; Olson, BA; Weinstock, J | 1 |
| Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Gallant, P; Herrgard, S; Hunt, JP; Karaman, MW; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Treiber, DK; Wodicka, LM; Zarrinkar, PP | 1 |
| Hajduk, PJ; Johnson, EF; Kifle, L; Merta, PJ; Metz, JT; Soni, NB | 1 |
| Russu, WA; Shallal, HM | 1 |
| Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ | 1 |
| Ampasala, DR; Basson, MD; Hatfield, J; Rishi, AK; Suer, S; Vander Heide, R; Walsh, MF | 1 |
| Derebecka-Holysz, N; Holysz, M; Lehmann, TP; Trzeciak, WH | 1 |
| Chen, SC; Chiou, SJ; Chuang, LY; Guh, JY; Hwang, CC; Ko, YM; Lin, TD | 1 |
| Abo, Y; Ichikawa, H; Nakata, N; Sasaki, K; Shirasawa, S; Tomotsune, D; Yokoyama, T; Yoshie, S; Yue, F | 1 |
| Chang, JZ; Chen, HM; Deng, YT; Kuo, MY; Yang, WH | 1 |
| Abello, P; Aguillón, JC; Aravena, O; Catalán, D; Gárate, D; García-González, P; Molina, MC; Peña, C; Pesce, B; Ribeiro, CH; Rojas-Colonelli, N; Salazar, L | 1 |
| Pierucci-Alves, F; Schultz, BD; Yi, S | 1 |
| Kim, SH; Lee, SH; Lee, SY; Paek, AR; Yoon, K; You, HJ | 1 |
| Arai, K; Itoh, K; Liang, AC; Lok, J; Maki, T; Osumi, N; Takahashi, Y | 1 |
| Kaji, H; Kawao, N; Okada, K; Okumoto, K; Tamura, Y; Yano, M | 1 |
15 other study(ies) available for sb 203580 and 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide
| Article | Year |
|---|---|
Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5).
Topics: Activin Receptors, Type I; DNA-Binding Proteins; Enzyme Inhibitors; Fibronectins; Humans; Imidazoles; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; RNA, Messenger; Smad3 Protein; Structure-Activity Relationship; Trans-Activators; Tumor Cells, Cultured | 2002 |
A quantitative analysis of kinase inhibitor selectivity.
Topics: Binding Sites; Enzyme Activation; Humans; Phosphotransferases; Protein Binding; Protein Interaction Mapping; Protein Kinase Inhibitors; Proteome; Quantitative Structure-Activity Relationship | 2008 |
Navigating the kinome.
Topics: Drug Design; Pharmacogenetics; Protein Kinases; Proteome; Systems Biology | 2011 |
Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Pyrimidines; Stereoisomerism; Structure-Activity Relationship | 2011 |
Identification of potent Yes1 kinase inhibitors using a library screening approach.
Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship | 2013 |
Transforming growth factor-beta stimulates intestinal epithelial focal adhesion kinase synthesis via Smad- and p38-dependent mechanisms.
Topics: Animals; Benzamides; Cell Line; Cell Movement; Dioxoles; Focal Adhesion Protein-Tyrosine Kinases; Humans; Imidazoles; Intestinal Mucosa; Mitogen-Activated Protein Kinase 14; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; Rats; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta | 2008 |
TGF-beta inhibits CYP17 transcription in H295R cells acting via activin receptor-like kinase 5.
Topics: Activin Receptors; Adrenal Cortex; Benzamides; Cell Line; Colforsin; Cytochromes b5; Dichlororibofuranosylbenzimidazole; Dioxoles; Humans; Imidazoles; MAP Kinase Kinase 1; NADPH-Ferrihemoprotein Reductase; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; RNA, Messenger; Steroid 17-alpha-Hydroxylase; Transforming Growth Factor beta | 2009 |
Gefitinib attenuates transforming growth factor-β1-activated mitogen-activated protein kinases and mitogenesis in NRK-49F cells.
Topics: Animals; Benzamides; Cell Line; Collagen; Cyclin D1; Dioxoles; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; Gefitinib; Imidazoles; Kidney; MAP Kinase Signaling System; Mice; Mitosis; Models, Biological; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Quinazolines; Rats; Receptors, Transforming Growth Factor beta; Smad Proteins; Transforming Growth Factor beta1; Translational Research, Biomedical | 2011 |
Gene pathway analysis of the mechanism by which the Rho-associated kinase inhibitor Y-27632 inhibits apoptosis in isolated thawed human embryonic stem cells.
Topics: Amides; Apoptosis; Benzamides; Caspase 10; Caspase 3; Caspase 8; Cell Line; Cell Survival; Cryopreservation; Cryoprotective Agents; Dioxoles; Embryonic Stem Cells; Humans; Imidazoles; Interleukin-1beta; p38 Mitogen-Activated Protein Kinases; Pyridines; rho-Associated Kinases; Transforming Growth Factor beta | 2012 |
EGCG blocks TGFβ1-induced CCN2 by suppressing JNK and p38 in buccal fibroblasts.
Topics: Anthracenes; Benzamides; Catechin; Cell Line; Cells, Cultured; Connective Tissue Growth Factor; Dinoprostone; Dioxoles; Dose-Response Relationship, Drug; Fibroblasts; Flavonoids; Humans; Imidazoles; Lung; MAP Kinase Kinase 4; Mouth Mucosa; Oral Submucous Fibrosis; p38 Mitogen-Activated Protein Kinases; Protease Inhibitors; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2013 |
Blocking of p38 and transforming growth factor β receptor pathways impairs the ability of tolerogenic dendritic cells to suppress murine arthritis.
Topics: Animals; Arthritis, Experimental; Benzamides; CD4-Positive T-Lymphocytes; Dendritic Cells; Dioxoles; Enzyme Inhibitors; Imidazoles; Immune Tolerance; Male; MAP Kinase Signaling System; Mice; Mice, Inbred DBA; Pyridines; Receptors, Transforming Growth Factor beta | 2013 |
Transforming growth factor-β1 impairs CFTR-mediated anion secretion across cultured porcine vas deferens epithelial monolayer via the p38 MAPK pathway.
Topics: Animals; Anions; Anisomycin; Benzamides; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dioxoles; Enzyme Inhibitors; Epithelial Cells; Imidazoles; Infertility, Male; Male; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Protein Synthesis Inhibitors; Pyridines; RNA, Messenger; Swine; Transforming Growth Factor beta1; Vas Deferens | 2013 |
Tight junction protein 1 is regulated by transforming growth factor-β and contributes to cell motility in NSCLC cells.
Topics: Benzamides; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Dioxoles; Gene Expression Regulation; Humans; Imidazoles; NADPH Oxidases; Onium Compounds; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Transforming Growth Factor beta; RNA Interference; RNA, Small Interfering; Transforming Growth Factor beta; Zonula Occludens-1 Protein | 2015 |
p38 MAP kinase mediates transforming-growth factor-β1-induced upregulation of matrix metalloproteinase-9 but not -2 in human brain pericytes.
Topics: Benzamides; Brain; Cell Survival; Cells, Cultured; Central Nervous System Agents; Dioxoles; Enzyme Inhibitors; Humans; Imidazoles; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; p38 Mitogen-Activated Protein Kinases; Pericytes; Phosphorylation; Pyridines; Receptors, Transforming Growth Factor beta; Recombinant Proteins; Transforming Growth Factor beta1; Up-Regulation | 2014 |
Role of osteoclasts in heterotopic ossification enhanced by fibrodysplasia ossificans progressiva-related activin-like kinase 2 mutation in mice.
Topics: Activin Receptors, Type I; Alendronate; Alkaline Phosphatase; Animals; Benzamides; Calcium; Cell Line; Collagen Type I; Dioxoles; Imidazoles; Male; Mice; Mice, Nude; Mutation; Myoblasts; Myositis Ossificans; Ossification, Heterotopic; Osteoclasts; Peptides; Phosphorus; Pyridines | 2016 |