Compounds > sb 203580
Page last updated: 2024-09-05

sb 203580 and 2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz(h)imidazo(4,5-f)isoquinoline-7-one

sb 203580 has been researched along with 2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz(h)imidazo(4,5-f)isoquinoline-7-one in 4 studies

Compound Research Comparison

Studies
(sb 203580)		Trials
(sb 203580)		Recent Studies (post-2010)
(sb 203580)		Studies
(2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz(h)imidazo(4,5-f)isoquinoline-7-one)		Trials
(2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz(h)imidazo(4,5-f)isoquinoline-7-one)		Recent Studies (post-2010) (2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz(h)imidazo(4,5-f)isoquinoline-7-one)
3,48941,13747024

Protein Interaction Comparison

ProteinTaxonomysb 203580 (IC50)2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz(h)imidazo(4,5-f)isoquinoline-7-one (IC50)
Inhibitor of nuclear factor kappa-B kinase subunit betaHomo sapiens (human)0.3
3-phosphoinositide-dependent protein kinase 1Homo sapiens (human)0.02
Tyrosine-protein kinase JAK2Homo sapiens (human)0.1463
Tyrosine-protein kinase FynHomo sapiens (human)0.5
Tyrosine-protein kinase HCKHomo sapiens (human)7.7
Platelet-derived growth factor receptor betaHomo sapiens (human)1.49
Fibroblast growth factor receptor 1Homo sapiens (human)1.48
Platelet-derived growth factor receptor alphaHomo sapiens (human)1.49
Protein kinase C alpha typeHomo sapiens (human)1.2
Vascular endothelial growth factor receptor 1 Homo sapiens (human)1.52
Fibroblast growth factor receptor 2Homo sapiens (human)1.21
Fibroblast growth factor receptor 4Homo sapiens (human)1.48
Fibroblast growth factor receptor 3Homo sapiens (human)1.48
Tyrosine-protein kinase JAK1Homo sapiens (human)0.0865
Cyclin-dependent kinase 2Homo sapiens (human)3.3
Mitogen-activated protein kinase 3 Homo sapiens (human)1.78
Mitogen-activated protein kinase 1Homo sapiens (human)1.78
Non-receptor tyrosine-protein kinase TYK2Homo sapiens (human)0.1767
RAC-alpha serine/threonine-protein kinaseHomo sapiens (human)0.028
Vascular endothelial growth factor receptor 3Homo sapiens (human)0.69
Vascular endothelial growth factor receptor 2Homo sapiens (human)1.4
Dual specificity mitogen-activated protein kinase kinase 2Homo sapiens (human)0.16
Tyrosine-protein kinase CSKHomo sapiens (human)2.1
Tyrosine-protein kinase JAK1 Mus musculus (house mouse)0.015
Tyrosine-protein kinase JAK3Homo sapiens (human)0.0902
Dual specificity mitogen-activated protein kinase kinase 1Homo sapiens (human)0.16
Maternal embryonic leucine zipper kinaseHomo sapiens (human)0.33

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M1
Clutter, MR; Crane, JM; Krutzik, PO; Nolan, GP1
Hajduk, PJ; Johnson, EF; Kifle, L; Merta, PJ; Metz, JT; Soni, NB1
Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A1

Other Studies

4 other study(ies) available for sb 203580 and 2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz(h)imidazo(4,5-f)isoquinoline-7-one

ArticleYear
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-18, Volume: 104, Issue:51

    Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

2007
High-content single-cell drug screening with phosphospecific flow cytometry.
    Nature chemical biology, 2008, Volume: 4, Issue:2

    Topics: Animals; Cell Line, Tumor; Drug Evaluation, Preclinical; Flow Cytometry; Humans; Janus Kinases; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Phosphorus; Sensitivity and Specificity; Signal Transduction; STAT Transcription Factors

2008
Navigating the kinome.
    Nature chemical biology, 2011, Volume: 7, Issue:4

    Topics: Drug Design; Pharmacogenetics; Protein Kinases; Proteome; Systems Biology

2011
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
    The Biochemical journal, 2013, Apr-15, Volume: 451, Issue:2

    Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase

2013