sb 203580 and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one

Topics: Animals; Drug Design; Drug Evaluation, Preclinical; Humans; Molecular Targeted Therapy; Protein Kinase Inhibitors; Protein Kinases

Topics: Animals; Antiviral Agents; Drug Repositioning; Humans; Protein Kinase Inhibitors; Virus Diseases; Viruses

Topics: Androstadienes; Animals; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Maleimides; Morpholines; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Sirolimus; Wortmannin

Topics: Animals; Antineoplastic Agents; Cell Movement; Chromones; Deoxyuridine; Doxorubicin; Enzyme Inhibitors; Fatty Alcohols; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Morpholines; Neoplasm Metastasis; Paclitaxel; Pyridines; Ribavirin; Signal Transduction; Sirolimus

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides

Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera

Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

Topics: Drug Design; Pharmacogenetics; Protein Kinases; Proteome; Systems Biology

Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase

Topics: Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Drug Approval; Drug Repositioning; High-Throughput Screening Assays; Humans; Protein Kinase Inhibitors; SARS-CoV-2; United States; United States Food and Drug Administration; Virus Diseases

Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Enzyme Activation; Enzyme Inhibitors; Eosinophils; Flavonoids; Humans; Imidazoles; Immunoglobulin A; Immunoglobulin G; Interleukin-4; Interleukin-5; Microspheres; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Processing, Post-Translational; Pyridines; Receptors, Fc; Receptors, IgG; Rosette Formation; Signal Transduction; Th2 Cells; Wortmannin

Topics: Antibodies; Cell Line, Transformed; Cell Movement; Chromones; Dose-Response Relationship, Drug; Down-Regulation; Endothelium; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Genes, Dominant; Humans; Imidazoles; Integrin alpha3beta1; Integrins; Morpholines; Oncogene Protein p21(ras); Phenotype; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; Transfection; Up-Regulation

Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Blotting, Western; Bromodeoxyuridine; Bucladesine; Cell Cycle; Cell Division; Cells, Cultured; Chromones; Cyclin D1; Cyclin D2; Cyclin E; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Cyclins; DNA; Enzyme Inhibitors; Flavonoids; G1 Phase; Imidazoles; Liver; Male; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins; Pyridines; Rats; Rats, Wistar; Receptors, Platelet-Derived Growth Factor; RNA, Messenger; S Phase; Thymidine; Tritium

Topics: Androstadienes; Bacterial Toxins; CD4-Positive T-Lymphocytes; Chromones; Enterotoxins; Enzyme Inhibitors; Humans; Imidazoles; Immunosuppressive Agents; Morpholines; Phosphatidylinositol 3-Kinases; Pyridines; RNA, Messenger; Superantigens; Transcription, Genetic; Tumor Necrosis Factor-alpha; Wortmannin

Topics: Animals; Anisomycin; Arsenites; Cells, Cultured; Chromones; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Eukaryotic Initiation Factor-4F; Hot Temperature; Imidazoles; Kidney; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Peptide Initiation Factors; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Poly(A)-Binding Proteins; Protein Kinases; Pyridines; RNA-Binding Proteins; Sirolimus; TOR Serine-Threonine Kinases; Xenopus laevis

Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromones; DNA-Binding Proteins; Glucose; Homeodomain Proteins; Humans; Imidazoles; Insulin; Islets of Langerhans; Mitogen-Activated Protein Kinases; Morpholines; Oligodeoxyribonucleotides; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Promoter Regions, Genetic; Pyridines; Trans-Activators; Transfection; Wortmannin

Topics: Activating Transcription Factor 2; Androstadienes; Animals; Cell Line; Chromones; Cyclic AMP Response Element-Binding Protein; Dinitrophenols; Enzyme Activation; Flavonoids; Imidazoles; Interleukin-4; Mast Cells; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Pyridines; Rats; Serum Albumin; Transcription Factors; Wortmannin

Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Chromones; Enzyme Inhibitors; Epithelial Cells; Extracellular Matrix; Female; Flavonoids; Imidazoles; Mammary Glands, Animal; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines

Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Nucleus; Chromones; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Glucose; Homeodomain Proteins; Imidazoles; Insulin; Islets of Langerhans; MAP Kinase Kinase 6; Microscopy, Confocal; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Proinsulin; Promoter Regions, Genetic; Protein Kinase C; Protein Precursors; Pyridines; Signal Transduction; Trans-Activators; Transfection; Wortmannin

Topics: Adenosine; Androstadienes; Animals; Calcium; Cell Line; Chromones; Cricetinae; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Imidazoles; Indoles; Insulin; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyridines; Receptors, Purinergic P1; Virulence Factors, Bordetella; Wortmannin; Xanthines

Topics: Antineoplastic Agents; Cell Membrane Permeability; Cells, Cultured; Chromones; Colon; DNA-Binding Proteins; Electric Impedance; Enterotoxins; Enzyme Activation; Enzyme Inhibitors; Genistein; Humans; Imidazoles; Interferon-gamma; Intestinal Mucosa; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; STAT1 Transcription Factor; Superantigens; Trans-Activators

Topics: Adolescent; Adult; Antigens, CD; Asthma; Chromones; Enzyme Activation; Enzyme Inhibitors; Eosinophils; Female; Humans; Imidazoles; Immunoglobulin A; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Receptors, Fc; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Signal Transduction; Tumor Necrosis Factor-alpha

Topics: Androstadienes; Animals; Apoptosis; Cell Line; Chromones; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Hydrogen Peroxide; Hypertonic Solutions; I-kappa B Kinase; Imidazoles; Inflammation; Insulin-Like Growth Factor I; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Morpholines; NF-kappa B; Okadaic Acid; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Prostaglandins A; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Recombinant Fusion Proteins; Signal Transduction; Stress, Physiological; Transfection; Tumor Cells, Cultured; Wortmannin

Topics: 3T3 Cells; Adipocytes; Androstadienes; Animals; Apoptosis; Chromones; Culture Media, Serum-Free; Enzyme Inhibitors; Flavonoids; Imidazoles; In Situ Nick-End Labeling; Insulin-Like Growth Factor I; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Sirolimus; Wortmannin

Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Line; Chromones; Enzyme Activation; Enzyme Inhibitors; Genes, Reporter; Humans; Imidazoles; Isoenzymes; MAP Kinase Kinase 6; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Models, Biological; Morpholines; Muscles; Mutation; MyoD Protein; Myristic Acid; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Transcription, Genetic; Transfection

Topics: Animals; Cell Line, Transformed; Chromones; Drosophila Proteins; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; HIV Long Terminal Repeat; Humans; Imidazoles; Interleukin-1; Lipopolysaccharides; Luciferases; Membrane Glycoproteins; Mice; Mice, Inbred C3H; Mitogen-Activated Protein Kinases; Morpholines; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Prostaglandin D2; Pyridines; Receptors, Cell Surface; Signal Transduction; Toll-Like Receptor 4; Toll-Like Receptors; Transcriptional Activation

Topics: Animals; Binding Sites; Cell Hypoxia; Cell Line; Chromones; DNA-Binding Proteins; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Genetic Vectors; Genistein; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Mammals; Morpholines; Nuclear Proteins; Phosphatidylinositol 3-Kinases; Pyridines; rac1 GTP-Binding Protein; Recombinant Fusion Proteins; Signal Transduction; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured

Topics: Animals; Animals, Newborn; Bacterial Outer Membrane Proteins; Cell Differentiation; Cell Division; Cells, Cultured; Chromones; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Imidazoles; Immediate-Early Proteins; Immunoblotting; Lipoproteins; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Morpholines; Nerve Growth Factor; Neurons; PC12 Cells; Phosphotransferases; Plasmids; Protein Binding; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Transcription Factors; Transfection

Topics: Chromones; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Interleukin-1; Interleukin-8; Mitogen-Activated Protein Kinases; Morpholines; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proteins; Pyridines; Signal Transduction; TNF Receptor-Associated Factor 6; Transcription Factor AP-1; Tumor Cells, Cultured

Topics: Androstadienes; Apoptosis; Chemotaxis, Leukocyte; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Leukotriene B4; Lipopolysaccharides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Virulence Factors, Bordetella; Wortmannin

Topics: Animals; Anoikis; Apoptosis; Blotting, Western; Caspases; Cell Line; Cell Survival; Chromones; DNA Fragmentation; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Imidazoles; Immunoblotting; Luciferases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Morpholines; Mutation; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; rac1 GTP-Binding Protein; Signal Transduction; Time Factors

Topics: Androstadienes; Animals; Cell Adhesion Molecules; Cell Line; Chromones; Cytokines; Enzyme Inhibitors; Flavonoids; Fucose; Gene Expression Regulation; Imidazoles; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Kinetics; Ligands; Lipoproteins, LDL; Macrophages; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Morpholines; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Polysaccharides; Pyridines; Receptors, Immunologic; Receptors, Scavenger; Time Factors; Tumor Necrosis Factor-alpha; Wortmannin

Topics: Animals; Cell Line; Chromones; Enzyme Activation; Enzyme Inhibitors; Fibrosarcoma; Genes, Dominant; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Morpholines; Mutagenesis, Site-Directed; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; rac GTP-Binding Proteins; Transfection; Tumor Necrosis Factor-alpha

Topics: Animals; Blotting, Western; Cell Adhesion; Cell Line; Cells, Cultured; Chromones; Cloning, Molecular; Culture Media, Serum-Free; Cytoplasm; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Gene Library; Green Fluorescent Proteins; Imidazoles; Integrins; Laminin; Luminescent Proteins; Mice; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Morpholines; Neuroblastoma; Neurons; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphatidylinositol 3-Kinases; Precipitin Tests; Protein Binding; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Pyridines; Rats; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured

Topics: Apoptosis; Blotting, Western; Cell Survival; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Feedback, Physiological; Humans; Imidazoles; Interleukin-1; Keratinocytes; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pyridines; Reactive Oxygen Species; Signal Transduction; Tumor Necrosis Factor-alpha; Ultraviolet Rays

Topics: Animals; Cell Line; Chromones; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Hypertonic Solutions; Imidazoles; Kidney Medulla; Kidney Tubules, Collecting; Lipid Metabolism; MAP Kinase Signaling System; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Morpholines; Oligonucleotide Array Sequence Analysis; Osmotic Pressure; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Polymerase Chain Reaction; Protein Kinases; Pyridines; RNA, Messenger; Transcription, Genetic; Water-Electrolyte Balance

Topics: Alkaline Phosphatase; Animals; Biomarkers; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Differentiation; Chromones; Core Binding Factor Alpha 1 Subunit; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neoplasm Proteins; Osteoblasts; Osteocalcin; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Transcription Factors; Transforming Growth Factor beta

Topics: Androstadienes; Animals; Chromones; Female; Imidazoles; Insulin; Isoproterenol; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Skeletal; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Potassium; Pyridines; Rats; Rats, Sprague-Dawley; Rubidium Radioisotopes; Sodium-Potassium-Chloride Symporters; Wortmannin

Topics: Animals; Carrier Proteins; Cell Line; Chromones; Curcumin; Enzyme Activation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Gene Expression Regulation; Genes, Dominant; Imidazoles; Interleukin-1; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; MAP Kinase Kinase 4; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Models, Biological; Morpholines; Naphthalenes; Oxygen; p38 Mitogen-Activated Protein Kinases; Protein Binding; Pyridines; rac1 GTP-Binding Protein; Reactive Oxygen Species; Signal Transduction; Time Factors; Transfection

Topics: Androstadienes; Animals; Cattle; Chromones; Cytosol; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Glutathione Transferase; Imidazoles; Immunohistochemistry; Mitogen-Activated Protein Kinases; Morpholines; NADPH Oxidases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoproteins; Protein Binding; Protein Structure, Tertiary; Pyridines; rac GTP-Binding Proteins; Recombinant Fusion Proteins; Superoxides; Time Factors; Wortmannin; Zymosan

Topics: Albuterol; Basophils; Calcimycin; Calcium Channel Blockers; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Histamine Release; Humans; Imidazoles; Immunoglobulin E; Interleukin-13; Interleukin-4; Interleukins; Leukotriene C4; MAP Kinase Kinase 3; MAP Kinase Kinase 6; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Pyridines; Salmeterol Xinafoate; Second Messenger Systems; Theophylline

Topics: alpha-Synuclein; Animals; Blotting, Western; Cell Line; Cell Survival; Cells, Cultured; Chromones; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Morpholines; Nerve Tissue Proteins; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyridines; Rats; RNA, Messenger; Signal Transduction; Synucleins; Time Factors; Tumor Cells, Cultured

Topics: Animals; Blotting, Western; Cell Line; Chromones; Cyclooxygenase 2; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Imidazoles; Interferon-gamma; Isoenzymes; Kinetics; Lipopolysaccharides; Macrophages; Mice; Morpholines; Mutation; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nuclear Proteins; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Protein Binding; Pyridines; Salicylates; Signal Transduction; Time Factors; Trans-Activators; Transfection

Topics: Animals; Apoptosis; Carbazoles; Caspase Inhibitors; Caspases; Cell Survival; Cells, Cultured; Cerebellum; Chromones; Culture Media, Serum-Free; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Neurons; Neuroprotective Agents; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Potassium; Proto-Oncogene Proteins c-jun; Pyridines; Rats; RNA, Messenger; Signal Transduction

Topics: Angiogenesis Inhibitors; Butadienes; Cellular Senescence; Chemokine CCL20; Chemokine CCL21; Chemokines, CC; Chemotaxis, Leukocyte; Chromones; Dendritic Cells; Enzyme Inhibitors; Humans; Imidazoles; Lipopolysaccharides; Macrophage Inflammatory Proteins; Mitogen-Activated Protein Kinases; Monocytes; Morpholines; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, CCR6; Receptors, CCR7; Receptors, Chemokine; Signal Transduction; Up-Regulation

Topics: Acetyltransferases; Base Sequence; Cell Differentiation; Cells, Cultured; Chromones; Dendritic Cells; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation; Humans; Imidazoles; Interleukin-12; Interleukin-4; Kinetics; Leukocytes, Mononuclear; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Biosynthesis; Proteins; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Tissue Distribution

Topics: Cell Line; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epithelium; Flavonoids; Humans; Imidazoles; Immunoassay; Immunoblotting; Indoles; Interleukin-1; Lung; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Morpholines; Mucin-2; Mucins; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein Structure, Tertiary; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors

Topics: Animals; Anisomycin; Anti-Bacterial Agents; Blotting, Western; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Butadienes; Cell Line; Chromones; Endothelial Growth Factors; Enzyme-Linked Immunosorbent Assay; Flavonoids; Imidazoles; Intercellular Signaling Peptides and Proteins; Lymphokines; Mice; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Osteoblasts; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Biosynthesis; Protein Synthesis Inhibitors; Proteins; Pyridines; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

Topics: Animals; Binding Sites; Binding, Competitive; Cells, Cultured; Chromones; Enzyme Inhibitors; Estradiol; Female; Gene Expression Regulation; Genes, Reporter; Genetic Vectors; HeLa Cells; Humans; Imidazoles; Isoquinolines; L Cells; Mice; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Plasmids; Pyridines; Receptors, Estrogen; Sulfonamides; Tamoxifen; Transcription, Genetic

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Androstadienes; Animals; Antibodies; Benzophenanthridines; Benzopyrans; Blotting, Western; Brain-Derived Neurotrophic Factor; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Carbazoles; Cell Nucleus; Chromones; Cyclic AMP Response Element-Binding Protein; Cytosol; Enzyme Inhibitors; Flavonoids; Hippocampus; Imidazoles; Immunohistochemistry; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Male; Morpholines; Naphthalenes; Phenanthridines; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Pyridines; Pyrroles; Rats; Signal Transduction; Time Factors; Tyrphostins; Wortmannin

Topics: Androstadienes; Anthracenes; Cells, Cultured; Chromones; Connective Tissue Growth Factor; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation; Humans; Imidazoles; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Lung; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinases; Morpholines; Oligonucleotides, Antisense; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pyridines; RNA, Messenger; Smad2 Protein; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1; Wortmannin

Topics: Aniline Compounds; Arsenites; Cell Line; Chromones; Drug Resistance; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Morpholines; Mutation; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Purines; Pyridines; Signal Transduction; Stress, Physiological

Topics: Animals; BALB 3T3 Cells; Butadienes; Chromones; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Genes, Dominant; Imidazoles; Interleukin-1; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Signal Transduction; Transcription, Genetic

Topics: Androstadienes; Animals; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Imidazoles; Male; Mitogen-Activated Protein Kinases; Mitogens; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; Signal Transduction; Wortmannin

Topics: Adenocarcinoma; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Signet Ring Cell; Cell Communication; Cell Differentiation; Chromones; Humans; Imidazoles; MAP Kinase Kinase 3; MAP Kinase Kinase 6; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Mucin-1; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein-Tyrosine Kinases; Pyridines; rac GTP-Binding Proteins

Topics: Androstadienes; Anthracenes; Apoptosis; Butadienes; Cell Survival; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Leukemic; HL-60 Cells; Humans; Hydrogen Peroxide; Imidazoles; Insulin-Like Growth Factor I; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Kinetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oxazoles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Receptor, IGF Type 1; RNA, Messenger; Wortmannin

Topics: Animals; Blotting, Western; Cells, Cultured; Chromones; Cytokines; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flavonoids; Imidazoles; Janus Kinase 1; Male; MAP Kinase Signaling System; Morpholines; Myocardium; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Precipitin Tests; Protein Biosynthesis; Protein-Tyrosine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirolimus; Tyrphostins

Topics: Androstadienes; Animals; Apoptosis; Cells, Cultured; Chromones; Coronary Vessels; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Flavonoids; Humans; Imidazoles; In Situ Nick-End Labeling; Insulin-Like Growth Factor I; Microscopy, Electron, Scanning; Microscopy, Video; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth, Vascular; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; Staurosporine; Time Factors; Wortmannin

Topics: Arachidonic Acids; Cells, Cultured; Chromones; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Humans; Imidazoles; Indoles; Lipoproteins, LDL; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Morpholines; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phospholipases A; Protein Kinase C; Pyridines; Pyrrolidinones; Reactive Oxygen Species; Signal Transduction; src-Family Kinases; Type C Phospholipases; Umbilical Veins

Topics: Adenocarcinoma; Annexin A5; Apoptosis; Blotting, Western; Carrier Proteins; Caspases; Cell Line, Tumor; Cell Survival; Chromones; Cycloheximide; DNA Fragmentation; Dose-Response Relationship, Drug; Doxorubicin; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Humans; Imidazoles; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Kinetics; Lung Neoplasms; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Signal Transduction

Topics: Animals; Cell Cycle; Cell Differentiation; Cell Division; Cell Line; Chromones; Cyclin E; Cycloheximide; Enzyme Activation; Growth Inhibitors; Imidazoles; Interleukin-2; Interleukin-7; Lymphocyte Activation; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pyridines; Retinoblastoma Protein; Signal Transduction; T-Lymphocyte Subsets; Time Factors

Topics: Benzoquinones; Butadienes; Cells, Cultured; Chromones; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dental Pulp; Dexamethasone; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Isoenzymes; Lactams, Macrocyclic; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Membrane Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; NF-kappa B; Nitriles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Prostaglandin-Endoperoxide Synthases; Protein-Tyrosine Kinases; Pyridines; Quinones; Rifabutin; Signal Transduction; Sulfonamides

Topics: Apoptosis; CD11 Antigens; CD11b Antigen; Cell Cycle; Cell Division; Cell Survival; Chromones; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Flavonoids; Humans; Hydantoins; Imidazoles; Macrophages; Morpholines; p38 Mitogen-Activated Protein Kinases; Phenanthrenes; Prostaglandin D2; Pyridines; Time Factors; Tumor Cells, Cultured

Topics: Actin Cytoskeleton; Actins; Cadmium Chloride; cdc42 GTP-Binding Protein; Cell Line, Tumor; Cell Surface Extensions; Chromones; DNA-Binding Proteins; Enzyme Activation; Guanosine Triphosphate; Humans; Imidazoles; MAP Kinase Signaling System; Monomeric GTP-Binding Proteins; Morpholines; Oligodeoxyribonucleotides, Antisense; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Smad7 Protein; Stress Fibers; Trans-Activators; Transforming Growth Factor beta

Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Ascorbic Acid; Bradykinin; Cattle; Cerebral Arteries; Chromones; Culture Media; Culture Media, Serum-Free; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Genistein; Imidazoles; In Vitro Techniques; Indoles; Maleimides; Morpholines; Oxidative Stress; Potassium; Protein Kinase Inhibitors; Pyridines; Serum; Superoxide Dismutase; Time Factors; Vasoconstriction; Vasoconstrictor Agents; Vasodilation

Topics: Blotting, Western; Cadherins; Carcinoma; Cell Line, Tumor; Chromones; Clone Cells; Collagen; Drug Combinations; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Immunohistochemistry; Laminin; Morpholines; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proteoglycans; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Pyridines; Serine; Signal Transduction; Transfection; Urinary Bladder Neoplasms

Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Blotting, Western; Bone Marrow Cells; Carrier Proteins; Cathepsin K; Cathepsins; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chromones; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p18; Cyclin-Dependent Kinase Inhibitor p19; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Enzyme Inhibitors; Femur; Flavonoids; Gene Expression; Imidazoles; Isoenzymes; Macrophage Colony-Stimulating Factor; Macrophages; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Osteoclasts; Osteopetrosis; Pyridines; Radiography; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Reverse Transcriptase Polymerase Chain Reaction; Tartrate-Resistant Acid Phosphatase; Tumor Suppressor Proteins

Topics: Alkyl and Aryl Transferases; Androstadienes; Anthracenes; Antibodies, Monoclonal; Cells, Cultured; Chemotaxis; Chromones; Class I Phosphatidylinositol 3-Kinases; Farnesyltranstransferase; Flavonoids; Glucose; Humans; Imidazoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Lovastatin; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Polyisoprenyl Phosphates; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; ras Proteins; Sesquiterpenes; Sirolimus; TOR Serine-Threonine Kinases; Wortmannin

Topics: Androstadienes; Animals; Anthracenes; Cell Line; Cell Movement; Cell Survival; Chemokine CCL4; Chemotaxis; Chromones; Complement C5a; Diterpenes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Imidazoles; JNK Mitogen-Activated Protein Kinases; Macrophage Inflammatory Proteins; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Wortmannin

Topics: Aorta; Arteriosclerosis; Butadienes; Cell Division; Cells, Cultured; Chromones; Diabetes Complications; Hormones, Ectopic; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Recombinant Proteins; Resistin; Signal Transduction

Topics: Adult; Aged; Androstadienes; Antibodies, Monoclonal; Arthritis, Rheumatoid; CD28 Antigens; CD3 Complex; CD4-Positive T-Lymphocytes; Chemokines; Chromones; Cytokines; Female; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Interleukin-17; Leukocytes, Mononuclear; Lymphocyte Activation; Male; Middle Aged; Morpholines; NF-kappa B; Osteoarthritis; Phosphatidylinositol 3-Kinases; Phytohemagglutinins; Proto-Oncogene Proteins c-akt; Pyridines; Pyrrolidines; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thiocarbamates; Wortmannin

Topics: Animals; Aorta; Blotting, Western; Cell Line; Chromones; Enzyme Inhibitors; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Imidazoles; MAP Kinase Signaling System; Molecular Chaperones; Morpholines; Muscle, Smooth; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Piperidines; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Quinolones; Rats; Time Factors; Vasopressins

Topics: Animals; Apoptosis; Blotting, Western; Cell Line; Chromones; Flavonoids; Imidazoles; MAP Kinase Signaling System; Mice; Morpholines; Muscle Development; Myoblasts; NF-kappa B; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyridines

Topics: Carrier Proteins; Cell Line, Tumor; Cells, Cultured; Chromones; Endothelial Cells; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Immunohistochemistry; In Situ Hybridization; Membrane Proteins; Morpholines; Neoplasm Proteins; Neoplasms; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Signal Transduction; Transcription, Genetic; Up-Regulation; Vascular Endothelial Growth Factor A

Topics: Apoptosis; Blotting, Western; Chromones; Drug Interactions; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Flow Cytometry; Humans; Imidazoles; Indoles; Interleukin-10; Lipopolysaccharides; Morpholines; Neutrophils; NF-kappa B; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Kinase Inhibitors; Pyridines

Topics: Acrylates; Animals; Cadherins; Cell Line; Cell Proliferation; Chromones; Cytoskeletal Proteins; Down-Regulation; Flavonoids; Gene Expression Regulation, Enzymologic; Hepatocytes; Imidazoles; MAP Kinase Signaling System; Mice; Microvilli; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Proto-Oncogene Proteins c-raf; Pyridines; Signal Transduction; Snail Family Transcription Factors; Time Factors; Transcription Factors; Up-Regulation

Topics: Butadienes; Caseins; Chromones; Dental Pulp; Enzyme Inhibitors; Humans; Imidazoles; Mitogen-Activated Protein Kinase Kinases; Morpholines; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Porphyromonas endodontalis; Pyridines; Signal Transduction; Tissue Plasminogen Activator; Up-Regulation

Topics: Animals; Anthracenes; Apoptosis; Butadienes; Calcineurin Inhibitors; Caspases; Cell Nucleus; Chromones; Cyclosporine; DNA Fragmentation; Enzyme Inhibitors; Fluorescent Dyes; Imidazoles; Indoles; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Morpholines; Myocardium; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Porphyromonas gingivalis; Pyridines; Rats

Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Azepines; Calcium; Cells, Cultured; Chromones; Enkephalin, D-Penicillamine (2,5)-; Estrenes; GTP-Binding Protein alpha Subunits, Gi-Go; Imidazoles; Morpholines; Muscle Contraction; Muscle Proteins; Myocytes, Smooth Muscle; Myosin Light Chains; Myosin-Light-Chain Phosphatase; p21-Activated Kinases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Pyrrolidinones; Rabbits; Receptor, Adenosine A1; Receptor, Muscarinic M2; Receptors, G-Protein-Coupled; Receptors, Opioid, delta; Receptors, Somatostatin; Recombinant Fusion Proteins; RNA, Small Interfering; Signal Transduction; Somatostatin; Transfection

Topics: Anthracenes; Bile Duct Neoplasms; Butadienes; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromones; Clone Cells; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Gefitinib; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oncogene Protein v-akt; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Quinazolines; Radiation-Sensitizing Agents

Topics: Animals; Blotting, Western; Cell Line, Tumor; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; Interleukin-10; Monocytes; Morpholines; NF-kappa B; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pyridines; Receptors, Formyl Peptide; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serum Amyloid A Protein; Sulfones; Tumor Necrosis Factor-alpha

Topics: Adolescent; Adult; Butadienes; Chromones; Fibroblasts; Flavonoids; Humans; Imidazoles; Interleukin-8; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Receptors, Proteinase-Activated; Signal Transduction; Skin; STAT3 Transcription Factor; Thrombin; Tyrphostins

Topics: Butadienes; Cells, Cultured; Chromones; Cyclooxygenase 1; Cyclooxygenase 2; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Immunoblotting; Lipoproteins, HDL; Lipoproteins, HDL3; Morpholines; Nitriles; Oxidation-Reduction; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Time Factors

Topics: Animals; Apoptosis; bcl-Associated Death Protein; bcl-X Protein; Caspase 3; Caspases; Cell Survival; Cells, Cultured; Chromones; Cysteine Endopeptidases; Enzyme Inhibitors; Flavonoids; Gene Expression; Genes, bcl-2; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 1; Mice; Morpholines; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protozoan Proteins; Pyridines; Signal Transduction; Trypanosoma cruzi

Topics: Animals; Cell Line, Tumor; Chromones; Cyclic AMP-Dependent Protein Kinases; Flavonoids; Gene Expression Regulation, Neoplastic; Growth Hormone; Imidazoles; Indoles; Interleukin-6; Maleimides; Mitogen-Activated Protein Kinase Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor Pit-1; Transfection

Topics: Animals; Arachidonic Acids; Benzoxazines; Brain; Cell Nucleus; Cell Survival; Chromones; Cyclooxygenase 2; Dinoprostone; Endocannabinoids; Endothelial Cells; Enzyme Activation; Flavonoids; Fluorescent Antibody Technique; Glycerides; Imidazoles; Mice; Microscopy, Confocal; Mitogen-Activated Protein Kinases; Morpholines; Naphthalenes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Resorcinols; Theilovirus

Topics: Butadienes; Caseins; Cell Line, Tumor; Chromones; Culture Media, Conditioned; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Imidazoles; Interleukin-1alpha; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Morpholines; Nitriles; Osteosarcoma; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Porphyromonas gingivalis; Pyridines; Tissue Plasminogen Activator; Up-Regulation

Topics: Base Sequence; Cell Line, Transformed; Cells, Cultured; Chemokine CCL2; Chemotaxis, Leukocyte; Chromones; Cobalt; Endothelial Cells; Endothelium, Vascular; Flavonoids; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Imidazoles; Interleukin-8; Molecular Sequence Data; Morpholines; Protein Kinase Inhibitors; Pulmonary Artery; Pyridines; RNA, Messenger

Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Chromones; ErbB Receptors; Flavonoids; Genes, ras; Genes, Reporter; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Neuregulin-1; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras); Pyridines; Rats; Reactive Oxygen Species; Receptor, ErbB-4; Recombinant Fusion Proteins; Recombinant Proteins; Signal Transduction; Transfection

Topics: Animals; Anthracenes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromones; Enzyme Inhibitors; Flavonoids; Imidazoles; Interleukin-1beta; Mice; Morpholines; Nitric Oxide Synthase Type II; Organ of Corti; Phosphatidylinositol 3-Kinases; Pyridines; Signal Transduction; Transcriptional Activation; Up-Regulation

Topics: Animals; Butadienes; Calcium; Cattle; Chelating Agents; Chromones; Egtazic Acid; Extracellular Signal-Regulated MAP Kinases; Female; Hydrogen-Ion Concentration; Imidazoles; Indoles; Ionomycin; Maleimides; Morpholines; Neutrophils; Nitriles; p38 Mitogen-Activated Protein Kinases; Propionates; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; Sodium-Hydrogen Exchangers; Spectrometry, Fluorescence

Topics: alpha-Synuclein; Animals; Anthracenes; Blotting, Western; Butadienes; Chromones; Enzyme Inhibitors; Fibroblast Growth Factor 2; Gene Expression Regulation; Humans; Imidazoles; Introns; JNK Mitogen-Activated Protein Kinases; Models, Biological; Morpholines; Nerve Growth Factor; Nitriles; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic

Topics: Blotting, Western; Calcium; Cell Line, Tumor; Cell Movement; Chemotaxis; Chromones; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Lysophospholipids; Morpholines; Neoplasm Invasiveness; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Protein Isoforms; Proto-Oncogene Proteins c-akt; Pyridines; Receptors, Lysosphingolipid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sphingosine

Topics: Animals; Anthracenes; Bone Marrow Cells; Butadienes; Chromones; Dendritic Cells; Gene Expression; Gene Expression Regulation, Enzymologic; Imidazoles; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Janus Kinase 1; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Male; Mice; Mice, Inbred Strains; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyridines

Topics: Animals; Cell Line; Cell Proliferation; Chromones; Colitis; Dextran Sulfate; Electroporation; Female; Flavonoids; Genetic Therapy; Hepatocyte Growth Factor; Imidazoles; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Pyridines; Regeneration; RNA, Small Interfering; Signal Transduction

Topics: Active Transport, Cell Nucleus; Calcitriol; Cell Nucleus; Cells, Cultured; Chromones; Enzyme Inhibitors; Fatty Acids, Unsaturated; Flavonoids; Gene Expression Regulation; HL-60 Cells; Humans; Imidazoles; Leukemia; Models, Biological; Morpholines; Protein Biosynthesis; Pyridines; Receptors, Calcitriol; Signal Transduction

Topics: Adolescent; Apoptosis; B-Lymphocytes; Blood Cells; Bone Marrow Cells; Cell Division; Cell Survival; Chemokine CXCL12; Chemokines, CXC; Child; Child, Preschool; Chromones; Coculture Techniques; Culture Media, Serum-Free; Drug Synergism; Female; Humans; Imidazoles; Infant; Interleukin-3; Interleukin-7; Male; MAP Kinase Signaling System; Morpholines; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Pyridines; Receptors, CXCR4; Signal Transduction; Stromal Cells; Tumor Cells, Cultured

Topics: Animals; Bone Marrow Cells; Butadienes; Cell Differentiation; Cells, Cultured; Chemokine CCL3; Chromones; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Imidazoles; Mice; Morpholines; Nitriles; Oncogene Protein v-akt; Osteoblasts; Osteoclasts; Phosphatidylinositol 3-Kinases; Phosphorylation; Pyridines; RANK Ligand; Signal Transduction; Stromal Cells

Topics: Animals; Anthracenes; Apoptosis; Apoptosis Regulatory Proteins; Caspase Inhibitors; Caspases; Cell Line, Tumor; Cell Survival; Chromones; Dose-Response Relationship, Drug; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Fibrosarcoma; G1 Phase; Hypolipidemic Agents; Imidazoles; Mice; Models, Biological; Morpholines; Oligopeptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyridines; Signal Transduction; Sitosterols; Tumor Suppressor Protein p53

Topics: Apoptosis; Caspase 3; Cell Culture Techniques; Chromones; Clone Cells; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Fluorescein-5-isothiocyanate; Fluorescent Antibody Technique, Indirect; Fluorescent Dyes; Histidine; Humans; Imidazoles; Indoles; Jurkat Cells; Leukemia; Morpholines; Necrosis; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Recombinant Proteins; RNA, Small Interfering; T-Lymphocytes; TNF-Related Apoptosis-Inducing Ligand; Transfection

Topics: Animals; Butadienes; Cells, Cultured; Chromones; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Expression Regulation; Imidazoles; Interleukin-12; Interleukin-4; Mast Cells; Mice; Morpholines; Nitriles; Proto-Oncogene Proteins c-akt; Pyridines; Receptors, Proteinase-Activated; RNA, Messenger; Trypsin; Tryptases; Tyrphostins

Topics: Angiopoietin-1; Angiopoietin-2; Animals; Apoptosis; Cells, Cultured; Chromones; Dipeptides; Endothelial Cells; Fibroblasts; Humans; Imidazoles; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Morpholines; Neovascularization, Physiologic; NIH 3T3 Cells; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Peptide Hydrolases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Pyridines; Receptor, TIE-2; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Vascular Endothelial Growth Factor A

Topics: Abciximab; Antibodies, Blocking; Antibodies, Monoclonal; Cell Movement; Chemotaxis; Chromones; DNA; Enzyme Inhibitors; Fibrinogen; Flavonoids; Flow Cytometry; Humans; Imidazoles; Immunoblotting; Immunoglobulin Fab Fragments; Intercellular Adhesion Molecule-1; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Proto-Oncogene Proteins c-akt; Pyridines

Topics: Animals; Cell Hypoxia; Cell Line; Chromones; Endothelial Cells; Enzyme Inhibitors; Imidazoles; Interleukin-6; Janus Kinases; Lung; Morpholines; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Signal Transduction; STAT Transcription Factors; Xanthine Dehydrogenase

Topics: Androstadienes; Animals; Blotting, Western; Cell Line; Cells, Cultured; Chondrocytes; Chromones; Enzyme Induction; Enzyme Inhibitors; Enzymes; Flavonoids; Humans; Imidazoles; Interferon-gamma; Leptin; MAP Kinase Kinase 1; Morpholines; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Wortmannin

Topics: Anthracenes; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Division; Cell Line, Tumor; Chromones; Drug Screening Assays, Antitumor; Drug Synergism; Flavonoids; Gene Expression Regulation, Leukemic; HL-60 Cells; Humans; Imidazoles; Leukemia; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Monocytes; Morpholines; Neoplasm Proteins; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyridines; U937 Cells

Topics: Acetylation; Animals; Cell Line; Cell Shape; Chromatin; Chromones; E1A-Associated p300 Protein; Gene Expression Regulation, Developmental; Imidazoles; Insulin-Like Growth Factor I; MAP Kinase Kinase 6; Mice; Morpholines; Muscle Development; Myoblasts; MyoD Protein; Myogenic Regulatory Factors; p300-CBP Transcription Factors; p38 Mitogen-Activated Protein Kinases; Phenotype; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Promoter Regions, Genetic; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; RNA Interference; RNA, Small Interfering; Signal Transduction; Transcription, Genetic; Transfection

Topics: Animals; Arachidonic Acid; Ascorbic Acid; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Chromones; Cyclin D1; Cyclin E; Cyclin-Dependent Kinases; Embryonic Stem Cells; Flavonoids; G1 Phase; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phospholipases A2, Cytosolic; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Up-Regulation

Topics: Animals; Cell Differentiation; Chondrogenesis; Chromones; Collagen Type II; Enzyme Inhibitors; High Mobility Group Proteins; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Mesenchymal Stem Cells; Morpholines; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Rats; Rats, Wistar; RNA, Small Interfering; SOX9 Transcription Factor; Transcription Factors; Transforming Growth Factor beta

Topics: Animals; Cell Proliferation; Cells, Cultured; Chromones; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Fibroblasts; Imidazoles; Lung; Male; Morpholines; Myoblasts, Smooth Muscle; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Peptides, Cyclic; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Pyridines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B

Topics: Apoptosis; Cells, Cultured; Chromones; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; Interleukin-18; Kinetics; Lipopolysaccharides; Morpholines; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Propidium; Pyridines; Receptors, Interleukin-18; Signal Transduction

Topics: Anthracenes; Antigens, CD; B7-H1 Antigen; Carcinoma, Transitional Cell; Cell Line, Tumor; Chromones; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharide Receptors; Lipopolysaccharides; MAP Kinase Signaling System; Morpholines; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Pyridines; Toll-Like Receptor 4; Up-Regulation; Urinary Bladder Neoplasms

Topics: Anthracenes; Base Sequence; Cell Line, Tumor; Chromones; Cytochrome P450 Family 7; Elafin; Enzyme Activation; Estradiol; Estrogens; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; MAP Kinase Signaling System; Molecular Sequence Data; Morpholines; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; Pyridines; Steroid Hydroxylases

Topics: 3T3 Cells; Animals; Chromones; Collagen; Electromagnetic Fields; Equipment Design; Flavonoids; Imidazoles; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Mice; Morpholines; Osteoblasts; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction

Topics: Animals; Atherosclerosis; Cell Line; Cell Nucleus; Chromones; Endothelial Cells; Enzyme Inhibitors; HMGB1 Protein; Humans; Imidazoles; Macrophages; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Receptor, Serotonin, 5-HT1B; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin Agents; Umbilical Veins; Vascular Endothelial Growth Factor A

Topics: Animals; Cell Death; Cells, Cultured; Chromones; Culture Media, Serum-Free; Embryo, Mammalian; Enzyme Inhibitors; Imidazoles; Morpholines; Motor Neurons; Neurofilament Proteins; Organ Culture Techniques; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Poly(ADP-ribose) Polymerases; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Vascular Endothelial Growth Factor A

Topics: Anthracenes; Cell Line; Chromones; Colforsin; Corticotropin-Releasing Hormone; Dexamethasone; Flavonoids; Genes, Reporter; Humans; Hypothalamus; Imidazoles; Isoquinolines; Morpholines; Promoter Regions, Genetic; Protein Kinase Inhibitors; Pyridines; Regulatory Elements, Transcriptional; Sequence Deletion; Sulfonamides; Transfection

Topics: Acetophenones; Benzopyrans; Butadienes; Chromones; Gene Expression Regulation, Enzymologic; Genistein; Hexosaminidases; Humans; Imidazoles; Macrophages; MAP Kinase Signaling System; Monocytes; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphorylation; Prolactin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; RNA, Messenger; Tyrphostins

Topics: Adult; Androstadienes; Asthma; Bronchi; Cell Line; Cell Proliferation; Chromones; Enzyme Inhibitors; Female; Fluticasone; Humans; Imidazoles; Leptin; Male; Middle Aged; Morpholines; Pyridines; Receptors, Leptin; Recombinant Proteins; Respiratory Mucosa; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha

Topics: 3T3 Cells; Animals; Anthracenes; Butadienes; Cells, Cultured; Chromones; Dose-Response Relationship, Drug; Imidazoles; Mice; Morpholines; Naphthalenes; Nitriles; Osteoblasts; Phosphates; Prostaglandin D2; Pyridines; Signal Transduction; Sirolimus; Sodium

Topics: Adolescent; Bone Neoplasms; Cell Culture Techniques; Cell Movement; Cell Proliferation; Chromones; Deoxyuridine; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibrosarcoma; Flavonoids; Humans; Imidazoles; Male; Morpholines; Okadaic Acid; Osteosarcoma; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; Tumor Cells, Cultured

Topics: Animals; Apoptosis; Bacterial Toxins; Cell Line; Chromones; Clostridium Infections; Clostridium sordellii; Enzyme Activation; Enzyme Inhibitors; HeLa Cells; Humans; Imidazoles; Mice; Models, Biological; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; ras Proteins; Signal Transduction; Taurochenodeoxycholic Acid

Topics: Animals; Cell Line; Cell Nucleus; Chromones; Enzyme Activation; Enzyme Inhibitors; Female; Imidazoles; Interferon-gamma; Janus Kinase 2; Macrophages; Mice; Mice, Inbred BALB C; Morpholines; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C-alpha; Pyridines; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Tyrphostins

Topics: Actins; Animals; Aqueous Humor; Blotting, Western; Chromones; Corneal Opacity; Cryosurgery; Endothelium, Corneal; Enzyme Inhibitors; Fibroblast Growth Factor 2; Fluorescent Antibody Technique, Indirect; Imidazoles; Interleukin-1beta; Microscopy, Fluorescence; Morpholines; Neutrophil Infiltration; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Pyridines; Rabbits; Time Factors; Up-Regulation

Topics: Animals; Cell Line, Tumor; Cell Survival; Chromones; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Insulin; Insulin Secretion; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 1; Mice; Morpholines; Neuroendocrine Tumors; Octreotide; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Rats; Sirolimus; Somatostatin; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor A

Topics: Butadienes; Chromones; Down-Regulation; Humans; Imidazoles; Interleukin-1beta; Interleukins; Macrophage-1 Antigen; Morpholines; Neutrophils; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Pyridines; Receptors, Formyl Peptide; Signal Transduction; Up-Regulation

Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Choline O-Acetyltransferase; Chromones; Cinnamates; Disease Models, Animal; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Imidazoles; Infusion Pumps, Implantable; Male; Morpholines; Motor Activity; Motor Neurons; Nerve Degeneration; Neurotoxicity Syndromes; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Pyridines; Rats; Rats, Wistar; Spinal Cord; Time Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adult; Anthracenes; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chemokine CCL2; Chemokine CXCL10; Chemokine CXCL11; Chromones; Chronic Periodontitis; Enzyme Inhibitors; Female; Fibroblasts; Flavonoids; Gingiva; Humans; Imidazoles; Inflammation Mediators; Interferon-gamma; Interleukin-6; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Male; Middle Aged; Morpholines; Nod2 Signaling Adaptor Protein; Periodontal Attachment Loss; Periodontal Pocket; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Tumor Necrosis Factor-alpha

Topics: Animals; Bone Morphogenetic Protein 4; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, Cultured; Chromones; Enzyme Inhibitors; Flavonoids; Imidazoles; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Muscle Cells; Osteogenesis; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells

Topics: Cell Line, Tumor; Chromones; CREB-Binding Protein; Cyclic AMP; Female; Humans; Imidazoles; Male; Morpholines; Neoplasms; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Promoter Regions, Genetic; Protein Kinase Inhibitors; Pyridines; Response Elements; Transforming Growth Factor beta2; Up-Regulation

Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Chromones; Embryonic Stem Cells; Enzyme Inhibitors; Imidazoles; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Marine Toxins; Mice; Mitogen-Activated Protein Kinase 11; Morpholines; Oxazoles; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyridines

Topics: Catechin; Cells, Cultured; Chromones; Connexin 43; Culture Media, Serum-Free; Down-Regulation; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gap Junctions; Humans; Imidazoles; Morpholines; NG-Nitroarginine Methyl Ester; Pyridines; RNA, Small Interfering; Signal Transduction

Topics: Blotting, Western; Butadienes; Caco-2 Cells; Chromones; Humans; Imidazoles; Interferon-gamma; Intestinal Mucosa; Lacticaseibacillus casei; Membrane Proteins; Microscopy, Confocal; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Phosphoproteins; Probiotics; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Toll-Like Receptor 2; Tumor Necrosis Factor-alpha; Zonula Occludens-1 Protein

Topics: 4-Butyrolactone; Animals; Cell Line; Chromones; Erythropoietin; Flavonoids; Gene Expression Regulation; Glucose; Imidazoles; L-Lactate Dehydrogenase; Male; Morpholines; Neurons; Oxygen; Plasmids; Pyridines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Repressor Proteins; Transcription Factors

Topics: Animals; Cell Survival; Chromones; Enzyme Activation; Female; Free Radical Scavengers; Imidazoles; Male; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pregnancy; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Rats; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Sertoli Cells; Up-Regulation; Vitamin A

Topics: Aggrecans; Animals; Cartilage, Articular; Cattle; Cells, Cultured; Chondrocytes; Chromones; Collagen Type II; Drug Therapy, Combination; Endopeptidases; Flavonoids; Gene Expression Regulation, Enzymologic; Glucuronosyltransferase; Hyaluronan Receptors; Hyaluronic Acid; Imidazoles; Lactones; Morpholines; Oligosaccharides; Pyridines; Sesquiterpenes, Eudesmane; Signal Transduction; Viscosupplements

Topics: Animals; Anthracenes; Cecum; Cell Line; Cell Survival; Chromones; Cyclooxygenase 2; Disease Models, Animal; Drug Evaluation, Preclinical; Enzyme Activation; Enzyme Induction; Ethanol; Flavonoids; Flowers; Genetic Vectors; Heme Oxygenase-1; HMGB1 Protein; Imidazoles; Lipopolysaccharides; Lung; Macrophages; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Morpholines; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide Synthase Type II; Plant Extracts; Protein Transport; Prunella; Pyridines; Sepsis; Signal Transduction; Transfection

Topics: Animals; Chromones; Cytokines; Enzyme Inhibitors; Flavonoids; Hepatocytes; I-kappa B Proteins; Imidazoles; Insulin; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Morpholines; NF-kappa B; Nitric Oxide Synthase Type II; Nitrites; Plasmids; Proto-Oncogene Proteins c-akt; Pyridines; Rats

Topics: Animals; Apoptosis; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein 7; Cattle; Cells, Cultured; Chromones; Enzyme Inhibitors; Female; Granulosa Cells; Humans; Imidazoles; Morpholines; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Staurosporine

Topics: Animals; Anthracenes; Blotting, Western; Cells, Cultured; Chromones; Cytoplasmic Granules; Enzyme Activation; Enzyme Inhibitors; Group IV Phospholipases A2; Imidazoles; JNK Mitogen-Activated Protein Kinases; Kinetics; Lipids; Lipopolysaccharides; Membrane Proteins; Mice; Microglia; Microscopy, Confocal; Models, Biological; Morpholines; Oleic Acid; p38 Mitogen-Activated Protein Kinases; Perilipin-2; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Time Factors; Triglycerides

Topics: Apoptosis; Burns; Cells, Cultured; Chromones; Humans; Imidazoles; Insulin; Morpholines; Myocytes, Cardiac; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Serum; Tumor Necrosis Factor-alpha

Topics: Allergens; Animals; Blotting, Western; Butadienes; Cell Line, Tumor; Chromones; Cockroaches; Down-Regulation; Flavonoids; Flow Cytometry; Gene Expression Regulation; Imidazoles; Insect Proteins; Interleukin-12; MAP Kinase Signaling System; Mast Cells; Mice; Morpholines; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Pyridines; Recombinant Proteins; RNA, Messenger; Time Factors; Toll-Like Receptor 9

Topics: Cell Proliferation; Cells, Cultured; Chromones; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Endothelium, Vascular; Forkhead Box Protein O1; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Imidazoles; Morpholines; Myocytes, Smooth Muscle; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pyridines; Pyrroles; Quinazolines; RNA, Small Interfering; Saphenous Vein; Thrombin

Topics: Acetylcysteine; Cell Differentiation; Cells, Cultured; Chloroquine; Chromones; Copper Sulfate; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Gene Expression; Humans; Imidazoles; Leukocytes, Mononuclear; Lipoproteins, LDL; Lysosomes; Macrophages; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Morpholines; Naphthalenes; NF-kappa B; Oxidation-Reduction; PPAR gamma; Proteolysis; Pyridines; Signal Transduction; Transcription Factor AP-1; Transcriptional Activation; Up-Regulation

Topics: Acetylcysteine; Adult; Antioxidants; Catechin; Cell Culture Techniques; Cells, Cultured; Chromones; Curcumin; Cyclosporine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Fibroblasts; Flavonoids; Free Radical Scavengers; Gingiva; GTP-Binding Proteins; Humans; Imidazoles; Immunosuppressive Agents; Male; Morpholines; Oxidative Stress; Phosphoinositide-3 Kinase Inhibitors; Protease Inhibitors; Protein Glutamine gamma Glutamyltransferase 2; Pyridines; Reactive Oxygen Species; Transglutaminases; Up-Regulation

Topics: Analysis of Variance; Androstadienes; Animals; Blotting, Western; Butadienes; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Flavonoids; Glycation End Products, Advanced; Imidazoles; Intermediate-Conductance Calcium-Activated Potassium Channels; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; Patch-Clamp Techniques; Pyridines; Rats; RNA Interference; RNA, Small Interfering; Serum Albumin, Bovine; Signal Transduction; Wortmannin

Topics: Acetylcysteine; Animals; Anthracenes; Aorta; Butadienes; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Imidazoles; Inula; Male; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-E2-Related Factor 2; Nitriles; Platelet-Derived Growth Factor; Pyridines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sesquiterpenes

Topics: Animals; Choroid; Chromones; Cinnamates; Cyclic S-Oxides; Imidazoles; Indazoles; Indoles; Maleimides; MAP Kinase Signaling System; Morpholines; NF-kappa B; Organ Culture Techniques; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Plicamycin; Pyridines; Retinal Pigment Epithelium; Signal Transduction; Sus scrofa; Transcription Factors; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

Topics: Adrenergic beta-1 Receptor Agonists; Animals; Chromones; Disease Models, Animal; Dobutamine; Enzyme Inhibitors; Heart; Heme Oxygenase-1; HMGB1 Protein; Imidazoles; Male; Morpholines; Myocardial Reperfusion Injury; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protoporphyrins; Pyridines; Rats; Rats, Sprague-Dawley

Topics: Animals; Astrocytes; Blotting, Western; Chromones; Down-Regulation; Glucose; Imidazoles; Morpholines; Proteasome Endopeptidase Complex; Pyrazoles; Pyridines; Pyrimidines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tissue Plasminogen Activator

Topics: Antigens, Neoplasm; Benzylamines; Blotting, Western; Cell Line, Tumor; Cell Movement; Chemokine CXCL12; Chromones; Cyclams; Dose-Response Relationship, Drug; Extracellular Matrix; Female; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds; Humans; Imidazoles; Integrins; Morpholines; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Receptors, CXCR4; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Urokinase-Type Plasminogen Activator

Topics: 3T3-L1 Cells; Acetylcysteine; Adipocytes; Animals; Cell Hypoxia; Chemokine CCL2; Chromones; Endoplasmic Reticulum Stress; Imidazoles; Mice; Morpholines; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Palmitates; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Signal Transduction; Vascular Endothelial Growth Factor A

Topics: Animals; Butadienes; Cell Shape; Cell Survival; Chromones; Hydrogen Peroxide; Imidazoles; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Signal Transduction; Sus scrofa; Time Factors; Time-Lapse Imaging; Trabecular Meshwork

Topics: Antineoplastic Agents, Phytogenic; Berberine; Cell Adhesion; Cell Cycle; Cell Movement; Cell Proliferation; Chemokines; Chemokines, CXC; Chromones; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Intercellular Adhesion Molecule-1; Interleukin-8; Morpholines; Pyridines; Quinazolines; Signal Transduction; Stomach Neoplasms; Tumor Cells, Cultured

Topics: Animals; Apoptosis; Cell Line; Cell Survival; Chromones; Epithelial Cells; Fibronectins; Glutamine; Hot Temperature; HSP70 Heat-Shock Proteins; Imidazoles; Integrins; Intestines; Morpholines; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Rats; Signal Transduction; Stress, Physiological

Topics: Animals; Butadienes; Cell Movement; Cell Proliferation; Chromones; Ectoderm; Female; Gene Expression Regulation; Imidazoles; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pregnancy; Primary Cell Culture; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Receptor, IGF Type 1; Ribosomal Protein S6; RNA, Messenger; Signal Transduction; Swine; Trophoblasts

Topics: Apolipoprotein A-I; Atherosclerosis; ATP Binding Cassette Transporter 1; C-Reactive Protein; Cell Line, Tumor; Cholesterol; Chromones; Flavonoids; Foam Cells; Gene Expression; Gene Silencing; Humans; Imidazoles; Lipoproteins, LDL; Liver X Receptors; Mitogen-Activated Protein Kinase 3; Morpholines; Orphan Nuclear Receptors; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; PPAR gamma; Pyridines; Serum Amyloid P-Component; Signal Transduction

Topics: Animals; Cattle; Cells, Cultured; Chromones; Enzyme Inhibitors; Epithelial Cells; Female; Glucose; Imidazoles; Insulin; Lactation; Mammary Glands, Animal; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction

Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell Survival; Chromones; Extracellular Signal-Regulated MAP Kinases; Fibroblast Growth Factor 2; Flavonoids; HCT116 Cells; HeLa Cells; Humans; Imidazoles; Lymphocyte Activation; MCF-7 Cells; Membrane Proteins; Mice; Morpholines; Neoplasms; Nuclear Proteins; Protein Kinase C-delta; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Pyridines; Receptor, Fibroblast Growth Factor, Type 1; RNA Interference; Signal Transduction; Tumor Escape

Topics: Animals; Chromones; Dobutamine; HMGB1 Protein; Imidazoles; Interleukin-6; Male; Morpholines; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; NF-kappa B; Oxidative Stress; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Reperfusion Injury; Superoxide Dismutase; Tumor Necrosis Factor-alpha

Topics: Animals; Berberine Alkaloids; Cell Communication; Cell Differentiation; Chromones; Enzyme Activation; Fibroblasts; Fibrosis; Gene Expression Regulation, Enzymologic; Imidazoles; Mice; Morpholines; Myoblasts; MyoD Protein; Myogenin; p38 Mitogen-Activated Protein Kinases; Pyridines; Regeneration; Sarcopenia; Signal Transduction

Topics: Adrenergic beta-1 Receptor Agonists; Animals; Animals, Newborn; Cell Hypoxia; Cell Survival; Cells, Cultured; Chromones; Dobutamine; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); HMGB1 Protein; Imidazoles; In Vitro Techniques; Morpholines; Myocytes, Cardiac; NF-E2-Related Factor 2; Pyridines; Rats; Receptors, Adrenergic, beta-1

Topics: Anticoagulants; Antigens; Blotting, Western; Cells, Cultured; Chromones; Dactinomycin; Fatty Acids, Monounsaturated; Fluvastatin; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Indoles; Lipoproteins; Luciferases; Maleimides; Mevalonic Acid; Morpholines; Pyridines; Real-Time Polymerase Chain Reaction; RNA, Messenger; Up-Regulation

Topics: Alkaloids; Animals; Bone Marrow Cells; Cell Division; Cells, Cultured; Chromones; Colony-Forming Units Assay; Flavonoids; Imidazoles; MAP Kinase Signaling System; Mesenchymal Stem Cells; Mice; Mice, Inbred CBA; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyridines; Signal Transduction

Topics: Animals; Anthracenes; Benzophenanthridines; Cells, Cultured; Chromones; Colon; Flavonoids; Genistein; Imidazoles; Interstitial Cells of Cajal; Intestine, Small; Membrane Potentials; Mice; Mitogen-Activated Protein Kinases; Morpholines; Naphthalenes; Protein-Tyrosine Kinases; Pyridines; Rifabutin

Topics: Animals; Cell Line, Transformed; Cell Movement; Cell Proliferation; Chromones; Enzyme Activation; Gene Expression Regulation; Imidazoles; Mice; Morpholines; Nerve Growth Factors; Netrin-1; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyridines; Rats; Receptors, Cell Surface; Recombinant Proteins; Schwann Cells; Signal Transduction; Tumor Suppressor Proteins

Topics: Berberine; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Line, Tumor; Cell Proliferation; Chondrosarcoma; Chromones; Cyclin B1; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Enzyme Activation; G2 Phase Cell Cycle Checkpoints; Humans; Imidazoles; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Retinoblastoma Protein; Tumor Suppressor Protein p53; Up-Regulation

Topics: Acute-Phase Proteins; Cell Line; Cell Proliferation; Chromones; Flavonoids; Gene Expression Regulation, Neoplastic; Hepatocyte Growth Factor; Humans; Imidazoles; Lipocalin-2; Lipocalins; Matrix Metalloproteinase 9; Morpholines; Neoplasm Metastasis; NF-kappa B; Proto-Oncogene Proteins; Pyridines; Signal Transduction; Stomach Neoplasms

Topics: Animals; Chromones; Erythropoiesis; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hematopoietic Stem Cells; Imidazoles; Immunomagnetic Separation; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyridines; Signal Transduction

Topics: Adult; Ascorbic Acid; Case-Control Studies; Chromones; Humans; Imidazoles; Infant, Newborn; Infant, Premature; Morpholines; Neutrophils; p38 Mitogen-Activated Protein Kinases; Phagocytosis; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Reactive Oxygen Species

Topics: Acetylation; Blotting, Western; Calcium; Capillary Permeability; Cell Membrane Permeability; Cells, Cultured; Chromones; Endothelial Cells; Humans; Imidazoles; Microscopy, Fluorescence; Molecular Weight; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Retina; Serum Albumin; Transcytosis; Tubulin

Topics: Anthracenes; Atherosclerosis; Basigin; Butadienes; Chromones; Flow Cytometry; Foam Cells; Gene Expression Regulation; Gene Silencing; Humans; Imidazoles; Lipoproteins, LDL; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Signal Transduction; U937 Cells; Up-Regulation; Vascular Endothelial Growth Factor A

Topics: Anemia; Animals; Bone Marrow Cells; Chromones; Disease Models, Animal; Erythropoiesis; Erythropoietin; Flavonoids; Gene Expression Regulation; Hemorrhage; Imidazoles; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pyridines; Signal Transduction

Topics: Animals; Cartilage, Articular; Cell Dedifferentiation; Cell Differentiation; Chondrocytes; Chromones; Cysteamine; Endoplasmic Reticulum Stress; Glutaredoxins; Imidazoles; MAP Kinase Signaling System; Morpholines; Peptides; Phosphatidylinositol 3-Kinases; Pyridines; Rabbits

Topics: Analysis of Variance; Antineoplastic Agents; Apoptosis; Butadienes; Cell Line, Tumor; Cell Proliferation; Chromones; Drug Synergism; Enzyme Inhibitors; Female; G1 Phase; Humans; Imidazoles; Isoflavones; MAP Kinase Signaling System; Matrix Metalloproteinases; Membrane Potential, Mitochondrial; Morpholines; Nitriles; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Reactive Oxygen Species; Resting Phase, Cell Cycle; Signal Transduction

Topics: Animals; Bone Marrow Cells; Chromones; Flavonoids; Gene Expression Regulation; Gold Sodium Thiomalate; Granulocyte Colony-Stimulating Factor; Granulocytes; Imidazoles; Immobilization; Leukopoiesis; Macrophages; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Signal Transduction; Stress, Psychological

Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Cycle Checkpoints; Cell Differentiation; Cells, Cultured; Chromones; Cyclin-Dependent Kinase Inhibitor p21; Ducks; Imidazoles; MEF2 Transcription Factors; Morpholines; Myoblasts; Myogenic Regulatory Factors; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Pyridines; RNA, Messenger; Signal Transduction; Up-Regulation

Topics: Azo Compounds; Chromones; Gene Expression Regulation; Hep G2 Cells; Humans; Imidazoles; Lipid Droplets; Morpholines; Oleic Acid; Oxazoles; Perilipin-5; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; PPAR alpha; Pyridines; Staining and Labeling; Sulfones; Thiophenes; Tyrosine

Topics: Apoptosis; Cell Line, Tumor; Chromones; Flavonoids; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Hepatocyte Growth Factor; Humans; Imidazoles; Morpholines; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Pyridines; Stomach Neoplasms; Up-Regulation