sb 202190 and u 0126
sb 202190 has been researched along with u 0126 in 55 studies
Research
Studies (55)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (1.82) | 18.2507 |
| 2000's | 32 (58.18) | 29.6817 |
| 2010's | 22 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Caivano, M; Cohen, P; Davies, SP; Reddy, H | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N | 1 |
| Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M | 1 |
| Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
| Derynck, R; Fan, H | 1 |
| Hatanaka, H; Ikeuchi, T; Ishikawa, Y | 1 |
| Cheeran, MC; Cox, D; Hu, S; Lokensgard, JR; Peterson, PK; Sheng, W; vanOijen, M | 1 |
| Hallsworth, MP; Hirst, SJ; Lai, D; Moir, LM | 1 |
| Díaz-Ruiz, O; Drucker-Colín, R; Elder, JH; Galicia, O; Méndez-Díaz, M; Navarro, L; Prospéro-García, O; Sanna, PP | 1 |
| Leung, HY; Mehta, PB; Neal, DE; Robson, CN | 1 |
| Bueno, OF; Dai, YS; Liang, Q; Markham, BE; Molkentin, JD; Wiese, RJ | 1 |
| Agthong, S; Boulton, AJ; Fernyhough, P; Jude, EB; Middlemas, A; Purves, T; Tomlinson, DR | 1 |
| Becker, PM; Birukova, A; Booth, MA; Garcia, JG; Liu, F; Verin, AD | 1 |
| Naruse, Y; Oh-hashi, K; Tanaka, M | 1 |
| Curiel, T; Daniel, B; Heidenreich, K; Marches, F; Sonda, S; Wei, S | 1 |
| Chen, P; Ehrhardt, C; Flory, E; Jassoy, C; Koutsilieri, E; Ludwig, S; Scheller, C; Sopper, S; ter Meulen, V | 1 |
| Atherton, HC; Danahay, H; Jones, G | 1 |
| Ariga, K; Hosono, N; Meng, W; Nakase, T; Okuda, S; Tamura, Y; Yonenobu, K; Yoshikawa, H | 1 |
| Hirst, SJ; Matsuda, T; Peng, Q | 1 |
| Arteaga, CL; Dumont, N; Koh, Y; Ueda, Y; Wang, S; Yi, JY | 1 |
| Asaumi, N; Ikeda, K; Ishimaru, F; Niiya, K; Niiya, M; Shibakura, M; Shinagawa, K; Tanimoto, M; Teshima, T; Yoshida, C | 1 |
| Fainboim, L; Fuertes, MB; Ilarregui, JM; Molinero, LL; Rabinovich, GA; Rubinstein, N; Toscano, MA; Zwirner, NW | 1 |
| Shafer, LM; Slice, LW | 1 |
| Collman, RG; Freedman, BD; Lee, C; Tomkowicz, B | 1 |
| Akaike, A; Hakozaki, H; Komasaka, K; Kotake, Y; Kume, T; Nakatsu, Y; Ohta, S; Taguchi, R | 1 |
| Batty, S; Chow, EM; Der, SD; Kassam, A; Mogridge, J | 1 |
| Chen, HW; Chen, WX; Hong, LC; Tsai, YY; Wu, JH; Wu, TS | 1 |
| Ellen, RP; Jobin, MC; McCulloch, CA; Virdee, I | 1 |
| Hatter, A; Liu, B; Zhang, P | 1 |
| Arredondo, J; Chernyavsky, AI; Grando, SA; Jolkovsky, DL; Pinkerton, KE | 1 |
| Croons, V; De Meyer, GR; Herman, AG; Martinet, W; Timmermans, JP | 1 |
| Daub, H; Mann, M; Olsen, JV; Pan, C | 1 |
| Baraldi, PG; Borea, PA; Fogli, E; Gessi, S; Leung, E; Maclennan, S; Merighi, S; Sacchetto, V; Tabrizi, MA; Varani, K | 1 |
| Blank, V; Carrière, L; Derjuga, A; Gasiorek, J; Mardini, L; Paw, BH; Ponka, P; Schranzhofer, M | 1 |
| Do, EK; Kim, JH; Kim, KH; Kim, MY; Shin, SH; Song, HY | 1 |
| Aarstad, HJ; Olofsson, J; Olsnes, C | 1 |
| Aggarwal, S; Rao, RK; Samak, G | 1 |
| Gazdar, AF; Girard, L; Imai, H; Ishizuka, T; Kaira, K; Kakegawa, S; Minna, JD; Mori, M; Sato, M; Shames, DS; Shimizu, K; Sunaga, N | 1 |
| Grandal, MV; Grøvdal, LM; Holst, MR; Kim, J; Knudsen, SL; van Deurs, B | 1 |
| Barker, G; Lappas, M; Lim, R; Menon, R; Permezel, M; Rice, GE; Riley, C | 1 |
| Kim, CE; Kim, MH; Kim, SW | 1 |
| Fan, HQ; Li, Y; Wang, JG; Zou, J | 1 |
| Berger, S; Dyugovskaya, L; Lavie, L; Polyakov, A | 1 |
| Barthwal, MK; Dikshit, M; Keshari, RS; Verma, A | 1 |
| Im, SY; Kim, HA; Kim, KJ; Lee, HK; Seo, KH | 1 |
| Deng, XL; Li, GR; Su, XL; Wang, Y; Zhao, LM | 1 |
| Jia, B; Li, H; Lu, D; Lv, X; Peng, X; Wang, F; Wang, H; Wang, Y; Yu, X | 1 |
| Nemoto, E; Shimauchi, H; Suzuki, R | 1 |
| Bian, J; Dai, N; Gao, Q; Gu, J; Liu, W; Liu, X; Liu, Z; Yao, L; Yuan, Y; Zhao, H; Zou, H | 1 |
| Blank, V; Garcia-Santos, D; Gasiorek, JJ; Hui, ST; Mikhael, M; Ponka, P | 1 |
| Bauer, D; Darling-Reed, S; Day, A; Flores-Rozas, H; Mazzio, E; Redmon, N; Reuben, JS; Sadrud-Din, S; Soliman, KF; Taka, E | 1 |
| Fukami, K; Kudo, K; Nakamura, Y; Sawada, M; Uchida, T; Yoneda, A | 1 |
| Cooper, D; Granville, DJ; Merkulova, Y; Parkinson, LG; Raithatha, S; Sharma, M; Shen, Y | 1 |
| Delamere, NA; Mandal, A; Shahidullah, M | 1 |
Other Studies
55 other study(ies) available for sb 202190 and u 0126
| Article | Year |
|---|---|
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides | 2000 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
The selectivity of protein kinase inhibitors: a further update.
Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera | 2007 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2007 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades.
Topics: Animals; Butadienes; CHO Cells; Cricetinae; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; L-Selectin; MAP Kinase Kinase 1; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Pyridines; Receptor Protein-Tyrosine Kinases; Recombinant Proteins; Signal Transduction; Transfection; Transforming Growth Factor alpha | 1999 |
Brain-derived neurotrophic factor accelerates nitric oxide donor-induced apoptosis of cultured cortical neurons.
Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Butadienes; Carbazoles; Cell Nucleus; Cell Survival; Cells, Cultured; Cerebral Cortex; Cycloheximide; Dactinomycin; DNA Fragmentation; Drug Synergism; Embryo, Mammalian; Enzyme Inhibitors; Female; Imidazoles; Immunoglobulin G; Indole Alkaloids; Kinetics; Male; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; Nitric Oxide Donors; Nitriles; Nitroprusside; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Wistar; Receptor, trkB; Signal Transduction | 2000 |
Robust expression of TNF-alpha, IL-1beta, RANTES, and IP-10 by human microglial cells during nonproductive infection with herpes simplex virus.
Topics: Astrocytes; Brain; Butadienes; Cell Death; Cells, Cultured; Chemokine CCL5; Chemokine CXCL10; Chemokines, CXC; Cytokines; Encephalitis, Herpes Simplex; Enzyme Inhibitors; Fetus; Herpesvirus 1, Human; Humans; Imidazoles; Interleukin-1; Microglia; Neurons; Nitriles; Pyridines; Signal Transduction; Tumor Necrosis Factor-alpha; Virus Replication | 2001 |
Inhibitors of mitogen-activated protein kinases differentially regulate eosinophil-activating cytokine release from human airway smooth muscle.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchi; Butadienes; Cytokines; Drug Evaluation, Preclinical; Eosinophils; Female; Flavonoids; Humans; Imidazoles; Lung Diseases, Obstructive; Male; MAP Kinase Kinase Kinase 1; Middle Aged; Mitogen-Activated Protein Kinases; Muscle, Smooth; Nitriles; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Up-Regulation | 2001 |
Inhibition of the ERK pathway prevents HIVgp120-induced REM sleep increase.
Topics: AIDS Dementia Complex; Animals; Brain; Butadienes; Drug Interactions; Enzyme Inhibitors; HIV Envelope Protein gp120; Imidazoles; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Wistar; REM Sleep Parasomnias; Sleep, REM; Wakefulness | 2001 |
Keratinocyte growth factor activates p38 MAPK to induce stress fibre formation in human prostate DU145 cells.
Topics: Animals; Butadienes; COS Cells; Enzyme Inhibitors; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Humans; Imidazoles; Male; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Pyridines; Signal Transduction; Time Factors; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2001 |
The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytes.
Topics: Adenoviridae; Animals; Animals, Newborn; Blotting, Western; Butadienes; Cells, Cultured; DNA-Binding Proteins; Enzyme Inhibitors; GATA4 Transcription Factor; Genes, Dominant; Glutathione Transferase; Imidazoles; Immunohistochemistry; Leucine; Luciferases; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Myocardium; Nitriles; Phosphorylation; Plasmids; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Serine; Time Factors; Transcription Factors; Transcriptional Activation; Zinc Fingers | 2001 |
A role for mitogen-activated protein kinases in the etiology of diabetic neuropathy.
Topics: Animals; Butadienes; Cell Survival; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Ganglia, Spinal; Glucose; Humans; Hydrogen Peroxide; Imidazoles; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neurons, Afferent; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Wistar; Sural Nerve | 2001 |
Differential regulation of diverse physiological responses to VEGF in pulmonary endothelial cells.
Topics: Actins; Animals; Butadienes; Cattle; Cell Division; Cell Membrane Permeability; Cells, Cultured; Chemotaxis; Cytoskeleton; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Lymphokines; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Pulmonary Artery; Pyridines; Pyrimidines; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; src-Family Kinases; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Intracellular calcium mobilization induces period genes via MAP kinase pathways in NIH3T3 cells.
Topics: 3T3 Cells; Animals; Butadienes; Calcium Signaling; Circadian Rhythm; Cyclic AMP; Down-Regulation; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Period Circadian Proteins; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; RNA, Messenger; Signal Transduction; Thapsigargin; Transcription Factors | 2002 |
Pyridinylimidazole p38 mitogen-activated protein kinase inhibitors block intracellular Toxoplasma gondii replication.
Topics: Animals; Butadienes; Cells, Cultured; Cholesterol; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Imidazoles; Inhibitory Concentration 50; Mitogen-Activated Protein Kinases; Mutation; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Toxoplasma | 2002 |
Caspase inhibitors induce a switch from apoptotic to proinflammatory signaling in CD95-stimulated T lymphocytes.
Topics: Amino Acid Chloromethyl Ketones; Antigens, CD; Apoptosis; Butadienes; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; fas Receptor; Gene Expression Regulation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Hydrogen-Ion Concentration; Imidazoles; Inflammation; Interferon-gamma; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Necrosis; NF-kappa B; Nitriles; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyridines; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Signal Transduction; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2002 |
IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation.
Topics: Bronchi; Bronchial Hyperreactivity; Butadienes; Cell Count; Cells, Cultured; Chromones; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Flavonoids; Goblet Cells; Humans; Imidazoles; Interleukin-13; Interleukin-4; Ion Channels; MAP Kinase Signaling System; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines | 2003 |
Mechanical stress-induced apoptosis of endplate chondrocytes in organ-cultured mouse intervertebral discs: an ex vivo study.
Topics: Animals; Apoptosis; Butadienes; Cell Count; Chondrocytes; Enzyme Inhibitors; Growth Plate; Imidazoles; In Situ Nick-End Labeling; Intervertebral Disc; Male; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Organ Culture Techniques; p38 Mitogen-Activated Protein Kinases; Pyridines; Stress, Mechanical | 2003 |
Signaling pathways regulating interleukin-13-stimulated chemokine release from airway smooth muscle.
Topics: Adult; Aged; Asthma; Bronchial Hyperreactivity; Butadienes; Cells, Cultured; Chemokine CCL11; Chemokines; Chemokines, CC; Down-Regulation; Female; Humans; Imidazoles; Inflammation; Interleukin-13; Interleukin-4; Male; Middle Aged; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth; Nitriles; Oligodeoxyribonucleotides, Antisense; p38 Mitogen-Activated Protein Kinases; Pyridines; Respiratory Mucosa; Signal Transduction; STAT6 Transcription Factor; Trans-Activators | 2004 |
Overexpression of HER2 (erbB2) in human breast epithelial cells unmasks transforming growth factor beta-induced cell motility.
Topics: Actins; Activin Receptors, Type I; Adenoviridae; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Blotting, Northern; Breast Neoplasms; Bromodeoxyuridine; Butadienes; Cell Cycle; Cell Division; Cell Line; Cell Line, Tumor; Cell Movement; Chromones; Disease Progression; DNA, Complementary; Enzyme Inhibitors; Epithelial Cells; Gene Expression Regulation; Genes, Reporter; Green Fluorescent Proteins; Humans; Imidazoles; Immunoblotting; Integrin beta1; Ligands; Luminescent Proteins; Microscopy, Fluorescence; Models, Genetic; Morpholines; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Precipitin Tests; Protein Serine-Threonine Kinases; Pseudopodia; Pyridines; rac1 GTP-Binding Protein; Receptor, ErbB-2; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Retroviridae; Signal Transduction; Transcription, Genetic; Transforming Growth Factor beta; Trastuzumab; Wound Healing | 2004 |
Involvement of ERK1/2 and p38 MAP kinase in doxorubicin-induced uPA expression in human RC-K8 lymphoma and NCI-H69 small cell lung carcinoma cells.
Topics: Blotting, Northern; Blotting, Western; Butadienes; Carcinoma, Small Cell; Caspase 3; Caspases; Cell Line, Tumor; Doxorubicin; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Lung Neoplasms; Lymphoma; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Poly Adenosine Diphosphate Ribose; Pyridines; Urokinase-Type Plasminogen Activator | 2004 |
Regulated expression of galectin-1 during T-cell activation involves Lck and Fyn kinases and signaling through MEK1/ERK, p38 MAP kinase and p70S6 kinase.
Topics: Antibodies, Monoclonal; Blotting, Western; Butadienes; Cell Proliferation; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Galectin 1; Gene Expression Regulation; Humans; Imidazoles; Interleukin-2; Leukocytes, Mononuclear; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); MAP Kinase Kinase 1; Models, Biological; Nitriles; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Pyridines; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; src-Family Kinases; T-Lymphocytes; Tetradecanoylphorbol Acetate; Time Factors; Up-Regulation | 2004 |
Anisomycin induces COX-2 mRNA expression through p38(MAPK) and CREB independent of small GTPases in intestinal epithelial cells.
Topics: Animals; Anisomycin; Bacterial Proteins; Bacterial Toxins; Blotting, Western; Butadienes; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; DNA Primers; Flavonoids; Gene Expression Regulation; Imidazoles; Intestinal Mucosa; Monomeric GTP-Binding Proteins; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Rats; RNA Interference; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Sorbitol | 2005 |
HIV-1 gp120-induced TNF-{alpha} production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways.
Topics: Androstadienes; Butadienes; Cells, Cultured; Chromones; Flavonoids; HIV Envelope Protein gp120; Humans; Imidazoles; Macrophages; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyridines; Receptors, CCR5; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha; Wortmannin | 2005 |
Glutamate excitotoxicity is involved in cell death caused by tributyltin in cultured rat cortical neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Tocopherol; Animals; Butadienes; Cell Death; Cell Survival; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Antagonism; Environmental Pollutants; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Fetus; Glutamic Acid; Imidazoles; Nitriles; Pregnancy; Pyridines; Rats; Rats, Wistar; Receptors, Glutamate; Trialkyltin Compounds | 2006 |
Inhibition of mitogen-activated protein kinase signalling by Bacillus anthracis lethal toxin causes destabilization of interleukin-8 mRNA.
Topics: 3' Untranslated Regions; Anthracenes; Antigens, Bacterial; Bacillus anthracis; Bacterial Toxins; Butadienes; Cells, Cultured; Endothelial Cells; Humans; Imidazoles; Interleukin-8; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Mitogen-Activated Protein Kinases; Nitriles; Promoter Regions, Genetic; Pyridines; RNA Stability; RNA, Messenger; Signal Transduction | 2006 |
Mitogen-activated protein kinase (MAPK) signalling pathways in HepG2 cells infected with a virulent strain of Klebsiella pneumoniae.
Topics: Apoptosis; Blotting, Western; Butadienes; Cell Line, Tumor; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Klebsiella pneumoniae; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Models, Biological; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Toll-Like Receptor 2; Toll-Like Receptor 4; Virulence | 2006 |
Activation of MAPK in fibroblasts by Treponema denticola major outer sheath protein.
Topics: Animals; Bacterial Proteins; Butadienes; Calcium; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Imidazoles; Immunoblotting; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Porins; Protein Kinases; Pyridines; Rats; Time Factors | 2007 |
Manganese chloride stimulates rat microglia to release hydrogen peroxide.
Topics: Animals; Animals, Newborn; Anthracenes; Butadienes; Cell Line; Cells, Cultured; Chlorides; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Hydrogen Peroxide; Imidazoles; Manganese Compounds; Microglia; NADPH Oxidases; Nitriles; Onium Compounds; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Rats, Inbred F344; Time Factors | 2007 |
Receptor-mediated tobacco toxicity: acceleration of sequential expression of alpha5 and alpha7 nicotinic receptor subunits in oral keratinocytes exposed to cigarette smoke.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha7 Nicotinic Acetylcholine Receptor; Bungarotoxins; Butadienes; Carbazoles; Conotoxins; Egtazic Acid; GATA2 Transcription Factor; Humans; Imidazoles; Indoles; Keratinocytes; Nerve Tissue Proteins; Nicotine; Nitriles; Phenols; Polyenes; Polyunsaturated Alkamides; Pyridines; Receptors, Nicotinic; RNA, Small Interfering; Signal Transduction; Smoking; Tobacco Smoke Pollution; Tyrphostins; Up-Regulation | 2008 |
The protein synthesis inhibitor anisomycin induces macrophage apoptosis in rabbit atherosclerotic plaques through p38 mitogen-activated protein kinase.
Topics: Animals; Anisomycin; Anthracenes; Aorta; Apoptosis; Butadienes; Carotid Arteries; Carotid Stenosis; Cell Line, Tumor; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Imidazoles; Macrophages; Macrophages, Alveolar; Mice; Mitogen-Activated Protein Kinases; Myocytes, Smooth Muscle; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rabbits; Tunica Intima; Tunica Media | 2009 |
Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.
Topics: Butadienes; Dasatinib; Databases, Protein; Epidermal Growth Factor; Fusion Proteins, bcr-abl; HeLa Cells; Humans; Imidazoles; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Proteome; Proteomics; Pyridines; Pyrimidines; Signal Transduction; Thiazoles; Up-Regulation | 2009 |
Modulation of metalloproteinase-9 in U87MG glioblastoma cells by A3 adenosine receptors.
Topics: Adenosine; Blotting, Western; Butadienes; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases; Glioblastoma; Humans; Imidazoles; Inositol Phosphates; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Nitriles; Phosphorylation; Pyridines; Receptor, Adenosine A3; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor AP-1; Transcriptional Activation | 2010 |
Antagonistic roles of the ERK and p38 MAPK signalling pathways in globin expression, haem biosynthesis and iron uptake.
Topics: Acetamides; Animals; Antineoplastic Agents; Blotting, Northern; Butadienes; Cell Differentiation; Cell Line, Tumor; Enzyme Inhibitors; Gene Expression; Globins; Heme; Hemoglobins; Imidazoles; Immunoblotting; Iron; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines | 2010 |
Platelet-activating factor receptor mediates oxidized low density lipoprotein-induced migration of bone marrow-derived mesenchymal stem cells.
Topics: Anthracenes; Becaplermin; Bone Marrow Cells; Butadienes; Cell Movement; Humans; Imidazoles; Lipoproteins, LDL; Mesenchymal Stem Cells; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Platelet Activating Factor; Platelet Membrane Glycoproteins; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Pyridines; Receptors, G-Protein-Coupled; RNA Interference; RNA, Small Interfering | 2010 |
MAPKs ERK and p38, but not JNK phosphorylation, modulate IL-6 and TNF-α secretion following OK-432 in vitro stimulation of purified human monocytes.
Topics: Anthracenes; Antineoplastic Agents; Butadienes; Cells, Cultured; Enzyme Inhibitors; Humans; Imidazoles; Interleukin-6; Leukocytes, Mononuclear; Lipopolysaccharides; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Picibanil; Pyridines; Teichoic Acids; Tumor Necrosis Factor-alpha | 2011 |
ERK is involved in EGF-mediated protection of tight junctions, but not adherens junctions, in acetaldehyde-treated Caco-2 cell monolayers.
Topics: Acetaldehyde; Actins; Adherens Junctions; Anthracenes; beta Catenin; Butadienes; Caco-2 Cells; Cadherins; Claudin-3; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; Inulin; Membrane Proteins; Nitriles; Occludin; Permeability; Phosphoproteins; Pyridines; Tight Junctions; Zonula Occludens-1 Protein | 2011 |
Oncogenic KRAS-induced interleukin-8 overexpression promotes cell growth and migration and contributes to aggressive phenotypes of non-small cell lung cancer.
Topics: Aged; Butadienes; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Line, Tumor; Cell Movement; Cell Proliferation; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Interleukin-8; Kaplan-Meier Estimate; Lung Neoplasms; Male; Mutation; Nitriles; Oligonucleotide Array Sequence Analysis; p38 Mitogen-Activated Protein Kinases; Phenotype; Pyridines; ras Proteins; RNA Interference; Smoking | 2012 |
EGF receptor inhibitors increase ErbB3 mRNA and protein levels in breast cancer cells.
Topics: Breast Neoplasms; Butadienes; Cell Line, Tumor; Chromones; ErbB Receptors; Erlotinib Hydrochloride; Female; Gefitinib; Gene Expression; Gene Expression Profiling; Humans; Imidazoles; MAP Kinase Kinase 1; Morpholines; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; RNA, Messenger; Signal Transduction; Tyrphostins; Up-Regulation | 2012 |
MAPK and AP-1 proteins are increased in term pre-labour fetal membranes overlying the cervix: regulation of enzymes involved in the degradation of fetal membranes.
Topics: Anthracenes; Butadienes; Cervix Uteri; Extracellular Signal-Regulated MAP Kinases; Extraembryonic Membranes; Female; Gentian Violet; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinases; Nitriles; p38 Mitogen-Activated Protein Kinases; Pregnancy; Pyridines; Quaternary Ammonium Compounds; Transcription Factor AP-1 | 2011 |
Flavonoids inhibit high glucose-induced up-regulation of ICAM-1 via the p38 MAPK pathway in human vein endothelial cells.
Topics: Anthracenes; Butadienes; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Flavanones; Glucose; Hesperidin; Humans; Hyperglycemia; Imidazoles; Intercellular Adhesion Molecule-1; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Resveratrol; Stilbenes; Up-Regulation; Veins | 2011 |
Effects of dihydropyridine calcium channel blockers on oxidized low-density lipoprotein induced proliferation and oxidative stress of vascular smooth muscle cells.
Topics: Amlodipine; Anthracenes; Butadienes; Calcium Channel Blockers; Cell Proliferation; Cells, Cultured; Dihydropyridines; Dose-Response Relationship, Drug; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Lipoproteins, LDL; MAP Kinase Signaling System; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; Time Factors | 2012 |
Short-term fibronectin treatment induces endothelial-like and angiogenic properties in monocyte-derived immature dendritic cells: involvement of intracellular VEGF and MAPK regulation.
Topics: Adult; Antigens, CD1; Butadienes; Cell Shape; Culture Media, Conditioned; Dendritic Cells; Endothelial Cells; Fibronectins; Flow Cytometry; Glycoproteins; Humans; Imidazoles; Leukocytes, Mononuclear; Male; MAP Kinase Signaling System; Mitochondria; Mitogen-Activated Protein Kinase 1; Monocytes; Neovascularization, Physiologic; Nitriles; p38 Mitogen-Activated Protein Kinases; Phagocytosis; Phenotype; Phosphorylation; Pyridines; Thrombomodulin; Time Factors; Time-Lapse Imaging; Vascular Endothelial Growth Factor A; Young Adult | 2012 |
Reactive oxygen species-induced activation of ERK and p38 MAPK mediates PMA-induced NETs release from human neutrophils.
Topics: Butadienes; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; MAP Kinase Signaling System; NADPH Oxidases; Neutrophils; Nitriles; Onium Compounds; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Reactive Oxygen Species; Tetradecanoylphorbol Acetate | 2013 |
PTEN/MAPK pathways play a key role in platelet-activating factor-induced experimental pulmonary tumor metastasis.
Topics: Androstadienes; Animals; Anthracenes; Butadienes; Cell Line; Humans; Imidazoles; Lung Neoplasms; MAP Kinase Signaling System; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet Activating Factor; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Pyridines; Wortmannin | 2012 |
KCa3.1 channels mediate the increase of cell migration and proliferation by advanced glycation endproducts in cultured rat vascular smooth muscle cells.
Topics: Analysis of Variance; Androstadienes; Animals; Blotting, Western; Butadienes; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Flavonoids; Glycation End Products, Advanced; Imidazoles; Intermediate-Conductance Calcium-Activated Potassium Channels; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; Patch-Clamp Techniques; Pyridines; Rats; RNA Interference; RNA, Small Interfering; Serum Albumin, Bovine; Signal Transduction; Wortmannin | 2013 |
α₁ adrenoceptor activation by norepinephrine inhibits LPS-induced cardiomyocyte TNF-α production via modulating ERK1/2 and NF-κB pathway.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Animals; Animals, Newborn; Butadienes; Endotoxemia; Enzyme Inhibitors; Gene Expression Regulation; Imidazoles; Lipopolysaccharides; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocardium; Myocytes, Cardiac; NF-kappa B; Nitriles; Norepinephrine; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Prazosin; Proto-Oncogene Proteins c-fos; Pyridines; Rats; Signal Transduction; Tumor Necrosis Factor-alpha | 2014 |
Cyclic tensile force up-regulates BMP-2 expression through MAP kinase and COX-2/PGE2 signaling pathways in human periodontal ligament cells.
Topics: Adult; Bite Force; Bone Morphogenetic Protein 2; Butadienes; Calcification, Physiologic; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Humans; Imidazoles; Male; Mastication; Molar, Third; Nitriles; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Periodontal Ligament; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Stress, Physiological; Sulfonamides; Up-Regulation; Young Adult | 2014 |
Osteoprotegerin induces podosome disassembly in osteoclasts through calcium, ERK, and p38 MAPK signaling pathways.
Topics: Actins; Animals; Blotting, Western; Butadienes; Calcium; Cell Differentiation; Cell Membrane Structures; Cells, Cultured; Chelating Agents; Egtazic Acid; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Kinase 2; Imidazoles; Mice; Microscopy, Electron, Scanning; Monocytes; Nitriles; Osteoclasts; Osteoprotegerin; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Signal Transduction; src-Family Kinases | 2015 |
Thioredoxin-interacting protein regulates the differentiation of murine erythroid precursors.
Topics: Animals; Anthracenes; Butadienes; Carrier Proteins; Cell Differentiation; Cell Line; Cell Line, Tumor; Erythroblasts; Erythropoiesis; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Heme; Imidazoles; Immunoblotting; Iron; JNK Mitogen-Activated Protein Kinases; Leukemia, Erythroblastic, Acute; Mice, Inbred C57BL; Mice, Knockout; Nitriles; p38 Mitogen-Activated Protein Kinases; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Thioredoxins | 2015 |
Diallyl disulfide inhibits TNFα induced CCL2 release through MAPK/ERK and NF-Kappa-B signaling.
Topics: Allyl Compounds; Anthracenes; Anticarcinogenic Agents; Butadienes; Cell Line, Tumor; Chemokine CCL2; Disulfides; Garlic; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Macrophages; MAP Kinase Kinase 4; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; NF-kappa B p50 Subunit; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyridines; Tumor Necrosis Factor-alpha | 2015 |
Phospholipase C δ1 in macrophages negatively regulates TLR4-induced proinflammatory cytokine production and Fcγ receptor-mediated phagocytosis.
Topics: Animals; Anthracenes; Butadienes; Cell Line; Gene Expression Regulation; Imidazoles; Interleukin-1beta; Lipopolysaccharides; Macrophages; Mice; Mice, Knockout; Mutation; Nitriles; p38 Mitogen-Activated Protein Kinases; Phagocytosis; Phosphatidylinositol 4,5-Diphosphate; Phospholipase C delta; Primary Cell Culture; Protein Kinase Inhibitors; Pyridines; Receptors, IgG; RNA, Small Interfering; Signal Transduction; Toll-Like Receptor 4 | 2016 |
Extracellular granzyme K mediates endothelial activation through the cleavage of protease-activated receptor-1.
Topics: Alpha-Globulins; Butadienes; Cell Adhesion; Cell Line; Chemokine CCL2; Gene Expression Regulation; Granzymes; Human Umbilical Vein Endothelial Cells; Humans; Imidazoles; Interleukin-6; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Monocytes; Nitriles; p38 Mitogen-Activated Protein Kinases; Proteolysis; Pyridines; Receptor, PAR-1; Signal Transduction | 2016 |
Src Family Kinase Links Insulin Signaling to Short Term Regulation of Na,K-ATPase in Nonpigmented Ciliary Epithelium.
Topics: Animals; Butadienes; Chromones; Ciliary Body; Enzyme Activation; Epithelium; Extracellular Signal-Regulated MAP Kinases; Heterocyclic Compounds, 3-Ring; Imidazoles; Insulin; Models, Biological; Morpholines; Nitriles; Ouabain; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pigmentation; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; Rubidium; Signal Transduction; Sodium-Potassium-Exchanging ATPase; src-Family Kinases; Sus scrofa; Time Factors | 2017 |