sauvagine has been researched along with phyllomedusin* in 2 studies
2 other study(ies) available for sauvagine and phyllomedusin
| Article | Year |
|---|---|
Pharmacological studies of 'sapo' from the frog Phyllomedusa bicolor skin: a drug used by the Peruvian Matses Indians in shamanic hunting practices.
The dried skin secretion from Phyllomedusa bicolor, 'sapo', is used by the Matses Indians of the Northern Peru, in shamanic rites mainly designed to improve luck in hunting. When rubbed into burned, exposed areas of the skin, the drug causes the prompt appearance of violent peripheral gastrointestinal and cardiovascular effects soon followed by remarkable central effects (increase in physical strength, heightening of senses, resistance to hunger and thirst, exalted capacity to face stress situations). All the peripheral and most of the central effects of 'sapo' can be ascribed to the exceptionally high content of the drug (up to 7% of its weight) in potently active peptides, easily absorbed through the burned, inflamed areas of the skin. The concentration in 'sapo' of the single peptides (phyllocaerulein, phyllomedusin, phyllokinin, demorphins and deltorphins) has been determined by bioassay, and peptide contents were correlated with the different symptoms of the 'sapo' intoxication. Topics: Amino Acid Sequence; Amphibian Proteins; Animals; Anura; Behavior, Animal; Bradykinin; Central Nervous System Agents; Ceruletide; Chromatography, Thin Layer; Diuresis; Drug Combinations; Female; Guinea Pigs; Hallucinogens; Humans; In Vitro Techniques; Indians, South American; Male; Molecular Sequence Data; Muscle, Smooth; Narcotics; Neuropeptides; Oligopeptides; Peptide Hormones; Peptides; Rats | 1993 |
Phyllomedusa skin: a huge factory and store-house of a variety of active peptides.
The skin of the neotropical hylid frogs belonging to the subfamily. Phyllomedusinae is a formidable factory and store-house of a variety of active peptides belonging to seven distinct families: the caeruleins (represented by phyllocaerulein), the bradykinins (phyllokinin), the tachykinins (phyllomedusin), the bombesins (phyllolitorin, [Leu8]phyllolitorin, rohdei-litorin), sauvagine, the dermorphins (dermorphin, [Hyp6]dermorphin) and finally the tryptophyllins (a set of 8-11 members). Another linear peptide and three diketopiperazines should be added to the list. The biochemical and pharmacological positions of the Phyllomedusa peptides within their families is briefly discussed, dwelling upon some recent and controversial data. Topics: Amino Acid Sequence; Amphibian Proteins; Animals; Anura; Bombesin; Bradykinin; Ceruletide; Nerve Tissue Proteins; Neuropeptides; Oligopeptides; Opioid Peptides; Peptide Hormones; Peptides; Skin Physiological Phenomena; Tachykinins | 1985 |