sarcosine and gsk923295

sarcosine has been researched along with gsk923295 in 13 studies

Research

Studies (13)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	11 (84.62)	24.3611
2020's	2 (15.38)	2.80

Authors

Authors	Studies
Annan, RS; Belmont, LD; Bergnes, G; Brejc, K; Chua, PR; Copeland, RA; Cornwell, WD; Desai, R; Dhanak, D; Diamond, MA; Faucette, LF; Finer, JT; Garcia, C; Giardiniere, M; Gilmartin, AG; Greshock, JD; Huang, PS; Jackson, JR; Knight, SD; Lad, L; Lee, Y; Lichtsteiner, S; Luo, L; McNulty, DE; Morgans, DJ; Nevins, N; Qian, X; Sakowicz, R; Schauer, SP; Sun, CM; Sutton, D; Vidal, JD; Wood, KW; Wooster, RF; Zhang, S	1
Carol, H; Gorlick, R; Houghton, PJ; Kang, MH; Keir, ST; Kolb, EA; Lock, RB; Maris, JM; Morton, CL; Reynolds, CP; Smith, MA; Wozniak, AW	1
Botbyl, JD; Chung, V; Heath, EI; Holen, KD; Johnson, BM; Kirby, LC; Lampkin, TA; Lynch, KM; Schelman, WR	1
Degenhardt, YY; Diskin, SJ; Haglund, E; Maris, JM; Mayes, PA; Moy, C; Toporovskya, Y; Wood, A; Wooster, R	1
Aguiar, P; Barisic, M; Geley, S; Maiato, H	1
Oleinikov, AV; Tcherniuk, SO	1
Barisic, M; Grishchuk, EL; Janke, C; Magiera, MM; Maiato, H; Pereira, AL; Silva e Sousa, R; Tripathy, SK; Zaytsev, AV	1
Bechi, B; Bennett, A; Procter, DJ; Taylor, SS; Thompson, S; Tighe, A	1
Cai, XJ; Dai, Y; Tang, JC; Wei, SS; Wu, K; Xu, M; Zheng, X	1
McClelland, SE; Tovini, L	1
Ando, T; Asai, A; Ogo, N; Ohba, M; Sawada, JI; Yamane, M	1
Kapoor, TM; Phua, DYZ; Pisa, R	1
Barra, V; Cilluffo, D; Di Leonardo, A	1

Trials

1 trial(s) available for sarcosine and gsk923295

Article	Year
First-time-in-human study of GSK923295, a novel antimitotic inhibitor of centromere-associated protein E (CENP-E), in patients with refractory cancer. Cancer chemotherapy and pharmacology, 2012, Volume: 69, Issue:3 Topics: Adult; Aged; Antimitotic Agents; Bridged Bicyclo Compounds, Heterocyclic; Chromosomal Proteins, Non-Histone; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Sarcosine; Treatment Outcome; Young Adult	2012

Article

Year

First-time-in-human study of GSK923295, a novel antimitotic inhibitor of centromere-associated protein E (CENP-E), in patients with refractory cancer.

Cancer chemotherapy and pharmacology, 2012, Volume: 69, Issue:3

Topics: Adult; Aged; Antimitotic Agents; Bridged Bicyclo Compounds, Heterocyclic; Chromosomal Proteins, Non-Histone; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Sarcosine; Treatment Outcome; Young Adult

2012

Other Studies

12 other study(ies) available for sarcosine and gsk923295

Article	Year
Antitumor activity of an allosteric inhibitor of centromere-associated protein-E. Proceedings of the National Academy of Sciences of the United States of America, 2010, Mar-30, Volume: 107, Issue:13 Topics: Allosteric Site; Animals; Antineoplastic Agents; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Chromosomal Proteins, Non-Histone; Dogs; Drug Screening Assays, Antitumor; Humans; In Vitro Techniques; Kinesins; Mice; Microtubules; Mitosis; Models, Molecular; Molecular Structure; Sarcosine; Xenograft Model Antitumor Assays	2010
Initial testing of the CENP-E inhibitor GSK923295A by the pediatric preclinical testing program. Pediatric blood & cancer, 2012, Volume: 58, Issue:6 Topics: Animals; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Chromosomal Proteins, Non-Histone; Female; Humans; Inhibitory Concentration 50; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasms, Experimental; Sarcosine; Xenograft Model Antitumor Assays	2012
Mitogen-activated protein kinase (MEK/ERK) inhibition sensitizes cancer cells to centromere-associated protein E inhibition. International journal of cancer, 2013, Feb-01, Volume: 132, Issue:3 Topics: Antineoplastic Agents; Apoptosis; Benzamides; Biomarkers, Tumor; Bridged Bicyclo Compounds, Heterocyclic; Camptothecin; Cell Line, Tumor; Cell Proliferation; Chromosomal Proteins, Non-Histone; Colonic Neoplasms; Dacarbazine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Irinotecan; Lung Neoplasms; M Phase Cell Cycle Checkpoints; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Neuroblastoma; Pancreatic Neoplasms; RNA Interference; RNA, Small Interfering; Sarcosine; Temozolomide	2013
Kinetochore motors drive congression of peripheral polar chromosomes by overcoming random arm-ejection forces. Nature cell biology, 2014, Volume: 16, Issue:12 Topics: Aurora Kinase A; Aurora Kinase B; Benzamides; Benzazepines; Bridged Bicyclo Compounds, Heterocyclic; Cell Division; Cell Line, Tumor; Chromosomal Proteins, Non-Histone; Chromosome Segregation; Cytoplasmic Dyneins; DNA-Binding Proteins; Dyneins; Humans; Kinesins; Kinetochores; Microtubules; Quinazolines; RNA Interference; RNA, Small Interfering; Sarcosine; Spindle Apparatus	2014
Pgp efflux pump decreases the cytostatic effect of CENP-E inhibitor GSK923295. Cancer letters, 2015, May-28, Volume: 361, Issue:1 Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Cell Proliferation; Chromosomal Proteins, Non-Histone; Cytostatic Agents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Female; Flow Cytometry; Humans; Immunoenzyme Techniques; Sarcoma; Sarcosine; Tumor Cells, Cultured; Uterine Neoplasms; Verapamil	2015
Mitosis. Microtubule detyrosination guides chromosomes during mitosis. Science (New York, N.Y.), 2015, May-15, Volume: 348, Issue:6236 Topics: Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Chromosomal Proteins, Non-Histone; Chromosome Segregation; Humans; Microtubules; Mitosis; Molecular Imaging; Sarcosine; Spindle Apparatus; Tubulin; Tyrosine	2015
Cenp-E inhibitor GSK923295: Novel synthetic route and use as a tool to generate aneuploidy. Oncotarget, 2015, Aug-28, Volume: 6, Issue:25 Topics: Aneuploidy; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Chromosomal Proteins, Non-Histone; Chromosomes; DNA Damage; Flow Cytometry; HCT116 Cells; HeLa Cells; Humans; Kinesins; Mitosis; Phenotype; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; RNA Interference; Sarcosine; Spindle Apparatus	2015
GSK923295 as a potential antihepatocellular carcinoma agent causing delay on liver regeneration after partial hepatectomy. Chinese medical journal, 2019, Feb-05, Volume: 132, Issue:3 Topics: Animals; Antineoplastic Agents; Blotting, Western; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferation; Chromosomal Proteins, Non-Histone; Electrophoresis, Polyacrylamide Gel; Female; Fluorescent Antibody Technique; Humans; Immunohistochemistry; Liver Neoplasms; Liver Regeneration; Mice; Mice, Inbred C57BL; Real-Time Polymerase Chain Reaction; Sarcosine; Xenograft Model Antitumor Assays	2019
Impaired CENP-E Function Renders Large Chromosomes More Vulnerable to Congression Failure. Biomolecules, 2019, 01-26, Volume: 9, Issue:2 Topics: Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Chromosomal Proteins, Non-Histone; Chromosome Aberrations; Chromosomes; Humans; Sarcosine	2019
Identification of benzo[d]pyrrolo[2,1-b]thiazole derivatives as CENP-E inhibitors. Biochemical and biophysical research communications, 2019, 11-12, Volume: 519, Issue:3 Topics: Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle Checkpoints; Cell Proliferation; Chromosomal Proteins, Non-Histone; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HCT116 Cells; HeLa Cells; Humans; Molecular Structure; Sarcosine; Structure-Activity Relationship; Tumor Cells, Cultured	2019
Distinct Mechanisms of Resistance to a CENP-E Inhibitor Emerge in Near-Haploid and Diploid Cancer Cells. Cell chemical biology, 2020, 07-16, Volume: 27, Issue:7 Topics: Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cell Proliferation; Chromosomal Proteins, Non-Histone; Diploidy; Drug Resistance, Neoplasm; Haploidy; Heterozygote; Humans; Microscopy, Fluorescence; Mutagenesis, Site-Directed; Protein Domains; Recombinant Proteins; Sarcosine	2020
P14 Genes, 2020, 07-20, Volume: 11, Issue:7 Topics: Aneuploidy; Bridged Bicyclo Compounds, Heterocyclic; Cell Proliferation; HCT116 Cells; Humans; Phenotype; Sarcosine; Tumor Suppressor Protein p14ARF	2020