sapropterin and nadp
sapropterin has been researched along with nadp in 66 studies
Research
Studies (66)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (12.12) | 18.7374 |
| 1990's | 36 (54.55) | 18.2507 |
| 2000's | 18 (27.27) | 29.6817 |
| 2010's | 4 (6.06) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Böhme, E; Heinzel, B; John, M; Klatt, P; Mayer, B; Schmidt, K | 1 |
| Ishihara, T; Kanai, T; Noguchi, T; Nunokawa, Y | 1 |
| Böhme, E; Heinzel, B; John, M; Klatt, P; Mayer, B | 1 |
| Adachi, H; Esumi, H; Iida, S; Oguchi, S; Ohshima, H; Sugimura, T; Suzuki, H | 1 |
| Busse, R; Mülsch, A | 1 |
| Eizawa, H; Hattori, R; Hiki, K; Kawai, C; Kosuga, K; Yui, Y | 1 |
| Böhme, E; Heinzel, B; John, M; Mayer, B; Schultz, G; Wachter, H; Werner, ER | 1 |
| Marletta, MA; Tayeh, MA | 1 |
| Kaufman, S; Milstien, S | 1 |
| Curtius, HC; Heintel, D; Leimbacher, W; Redweik, U; Zagalak, B | 1 |
| Chandrasurin, P; Cichetti, JA; Nichol, CA; Smith, GK | 1 |
| Katoh, S; Sueoka, T | 1 |
| Curtius, HC; Ghisla, S; Heintel, D; Kuster, T; Leimbacher, W; Niederwieser, A | 1 |
| Brown, GM; Primus, JP; Switchenko, AC | 1 |
| Nichol, CA; Smith, GK | 1 |
| Hevel, JM; Marletta, MA | 1 |
| Fukuto, JM; Griscavage, JM; Ignarro, LJ; Komori, Y | 1 |
| Chen, Y; Rosazza, JP | 1 |
| Corradin, SB; Janzer, RC; Juillerat-Jeanneret, L; Murata, J | 1 |
| Abu-Soud, HM; Stuehr, DJ; Yoho, LL | 1 |
| Lubeskie, A; Wolff, DJ | 1 |
| Hofmann, H; Schmidt, HH | 1 |
| Klatt, P; Mayer, B; Schmidt, K; Uray, G | 1 |
| Baek, KJ; Lucas, S; Stuehr, DJ; Thiel, BA | 1 |
| Dowling, TG; O'Rourke, JF; Tipton, KF | 1 |
| Cho, HJ; Martin, E; Nathan, C; Sassa, S; Xie, QW | 1 |
| Lincoln, J; Messersmith, WA | 1 |
| Giovanelli, J; Kaufman, S; Witteveen, CF | 1 |
| Hertelendy, F; Kukor, Z; Mészáros, G; Tóth, M | 1 |
| Ignarro, LJ; Sheng, H | 1 |
| Gorren, AC; Mayer, B; Schmidt, K; Schrammel, A | 2 |
| de Groot, F; Rabelink, TJ; van Dam, T; van Rijn, HJ; Wever, RM | 1 |
| Andrade, J; Bedoya, FJ; Conde, M; Ramírez, R; Sobrino, F | 1 |
| Harrison, DG | 1 |
| Geyer, O; Mittag, T; Podos, SM | 1 |
| Nishida, CR; Ortiz de Montellano, PR | 1 |
| Hogg, N; Kalyanaraman, B; Karoui, H; Martásek, P; Masters, BS; Pritchard, KA; Tordo, P; Vásquez-Vivar, J | 1 |
| Berka, V; Tsai, AL; Xia, Y; Zweier, JL | 1 |
| Marletta, MA; Rusche, KM; Spiering, MM | 1 |
| Gross, SS; Ikeda-Saito, M; Liu, Q; Martásek, P; Masters, BS; Migita, CT; Miller, RT; Raman, CS; Roman, LJ; Salerno, JC | 1 |
| Ludwig, ML; Marletta, MA | 1 |
| Boucher, JL; Dijols, S; Mansuy, D; Renodon-Cornière, A; Stuehr, DJ | 1 |
| Hogg, N; Kalyanaraman, B; Karoui, H; Martásek, P; Pritchard, KA; Vásquez-Vivar, J | 1 |
| Daff, S; Sagami, I; Sato, Y; Shimizu, T | 1 |
| Hatakeyama, K; Kelly, KA; Marinos, RS; Martinez-Zaguilan, R; Meininger, CJ; Rojas, JD; Wu, G | 1 |
| Adak, S; Stuehr, DJ; Wang, Q | 1 |
| Hurt, RD; Miller, VM; Severson, SR; Tonnessen, BH | 1 |
| Boucher, JL; Mansuy, D; Moali, C; Renodon-Corniere, A; Stuehr, DJ | 1 |
| Daff, S; Noguchi, T; Sagami, I; Shimizu, T | 1 |
| Conrad, KP; Davis, AK; Novak, J; Powers, RW | 1 |
| Adak, S; Aulak, KS; Bilwes, AM; Crane, BR; Getzoff, ED; Hosfield, D; McDonald, JF; Panda, K; Stuehr, DJ; Tainer, JA | 1 |
| Choi, JJ; Choi, JW; Kim, HC; Kim, HS; Kim, WK; Ko, KH; Lee, JC; Lee, SJ; Ryu, JR; Shin, CY | 1 |
| Arruda, P; Castro, GM; de Nucci, G; Langone, F; Martins, ML; Muscará, MN; Papes, F; Rogério, F; Santos, LM; Teixeira, SA | 1 |
| Meininger, CJ; Wu, G | 1 |
| Fiskum, G; Porasuphatana, S; Pou, S; Roman, LJ; Rosen, GM; Starkov, AA; Tsai, P; Weaver, J | 1 |
| Ghosh, S; Mukherjee, S; Regulski, M; Sahoo, R; Sengupta, R; Stuehr, DJ; Tully, T | 1 |
| Panda, K; Santolini, J; Stuehr, DJ; Wang, Q; Wang, ZQ; Wei, CC | 1 |
| Choi, YK; Han, CD; Lee, KH; Park, YS; Seo, KH; Son, D; Supangat, S | 1 |
| Doe, I; Kawabata, A; Kubo, S; Kurokawa, Y; Masuko, T; Sekiguchi, F | 1 |
| Cardounel, AJ; Chen, CA; Druhan, LJ; Forbes, SP; Pope, AJ; Zweier, JL | 1 |
| Datta, S; Kim, SW; Li, P; Li, X; Pond, WG; Wu, G | 1 |
| Gorska, KI; Haruki, H; Johnsson, K; Pedersen, MG; Pojer, F | 1 |
| Ambrosio, G; Boslett, J; De Pascali, F; Druhan, LJ; El-Mahdy, M; Hemann, C; Reyes, LA; Varadharaj, S; Zweier, JL | 1 |
| Chen, W; Harbeck, MC; He, D; Peng, H; Xie, L; Zhuang, Y | 1 |
| Belfield, G; Lewis, R; Narjes, F; Öberg, L; Ripa, L; Shamovsky, I; Sjö, P; Tyrchan, C | 1 |
Reviews
2 review(s) available for sapropterin and nadp
| Article | Year |
|---|---|
Cellular and molecular mechanisms of endothelial cell dysfunction.
Topics: Arginase; Arginine; Biopterins; Endothelium, Vascular; Humans; NAD; NADP; Nitric Oxide; Nitric Oxide Synthase; Superoxides | 1997 |
A new decoration for nitric oxide synthase - a Zn(Cys)4 site.
Topics: Animals; Arginine; Binding Sites; Biopterins; Citrulline; Cysteine; Dimerization; Electron Transport; Macromolecular Substances; Models, Molecular; NADP; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Protein Conformation; Zinc | 1999 |
Other Studies
64 other study(ies) available for sapropterin and nadp
| Article | Year |
|---|---|
Nitric oxide synthase-catalyzed activation of oxygen and reduction of cytochromes: reaction mechanisms and possible physiological implications.
Topics: Amino Acid Oxidoreductases; Arginine; Biopterins; Cerebellum; Cytochrome c Group; Electron Transport; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Hydrogen Peroxide; NADH Dehydrogenase; NADP; Nitric Oxide Synthase; Oxidation-Reduction; Oxygen | 1992 |
(6R)-5,6,7,8-tetrahydro-L-biopterin modulates nitric oxide-associated soluble guanylate cyclase activity in the rat cerebellum.
Topics: Animals; Arginine; Biopterins; Calcium; Calmodulin; Cerebellum; Cytosol; Guanylate Cyclase; Kinetics; Male; NADP; Nitric Oxide; Nitroprusside; Rats; Rats, Wistar | 1992 |
Ca2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Binding, Competitive; Biopterins; Brain; Calcium; Calmodulin; Citrulline; Hydrogen Peroxide; NADP; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Swine | 1992 |
Purification of nitric oxide synthase from bovine brain: immunological characterization and tissue distribution.
Topics: Amino Acid Oxidoreductases; Animals; Biopterins; Brain; Calcium; Calmodulin; Cattle; Isoenzymes; Kinetics; NADP; Nitric Oxide Synthase; Rats; Tissue Distribution | 1992 |
Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells.
Topics: Amino Acid Oxidoreductases; Animals; Aorta, Thoracic; Arginine; Biopterins; Cells, Cultured; Cyclic GMP; Cytokines; Enzyme Induction; In Vitro Techniques; Interferon-gamma; Interleukin-1; Muscle, Smooth, Vascular; NADP; Nitric Oxide; Nitric Oxide Synthase; Rabbits; Tumor Necrosis Factor-alpha | 1990 |
Purification of nitric oxide synthase from rat macrophages.
Topics: Amino Acid Oxidoreductases; Animals; Biopterins; Chromatography, Affinity; Chromatography, Gel; Dithiothreitol; Macrophages; Male; Molecular Weight; NADP; Nitric Oxide Synthase; Rats; Rats, Inbred Strains | 1991 |
Brain nitric oxide synthase is a biopterin- and flavin-containing multi-functional oxido-reductase.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Calcium; Calmodulin; Cerebellum; Citrulline; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Hydrogen Peroxide; Kinetics; NADP; Nitric Oxide; Nitric Oxide Synthase; Spectrophotometry; Swine | 1991 |
Macrophage oxidation of L-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactor.
Topics: Animals; Arginine; Biopterins; Cell Line; Chromatography, High Pressure Liquid; Citrulline; Cytosol; Kinetics; Macrophages; NADP; Nitrates; Nitric Oxide; Nitrites; Oxidation-Reduction | 1989 |
The biosynthesis of tetrahydrobiopterin in rat brain. Purification and characterization of 6-pyruvoyl tetrahydropterin (2'-oxo)reductase.
Topics: Alcohol Oxidoreductases; Amino Acids; Animals; Biopterins; Brain; Chromatography, Affinity; Chromatography, High Pressure Liquid; Ketone Oxidoreductases; Molecular Weight; NADP; Pterins; Rats; Substrate Specificity; Tissue Distribution | 1989 |
Purification and properties of the phosphate eliminating enzyme involved in the biosynthesis of BH4 in man.
Topics: Biopterins; Humans; Isoelectric Point; Liver; Magnesium; Molecular Weight; NADP; Neopterin; Pteridines; Pyrophosphatases; Temperature; Time Factors | 1985 |
The C-6 proton of tetrahydrobiopterin is acquired from water, not NADPH, during de novo biosynthesis.
Topics: Animals; Biopterins; Cattle; Deuterium; Gas Chromatography-Mass Spectrometry; Guanosine Triphosphate; Models, Chemical; NADP; Protons; Pteridines | 1985 |
Coenzyme stimulation of isomerase activity of sepiapterin reductase in the biosynthesis of tetrahydrobiopterin.
Topics: Alcohol Oxidoreductases; Animals; Biopterins; Coenzymes; Enzyme Activation; Erythrocytes; Isomerases; Kinetics; NADP; Rats | 1988 |
Tetrahydrobiopterin biosynthesis. Studies with specifically labeled (2H)NAD(P)H and 2H2O and of the enzymes involved.
Topics: Affinity Labels; Alcohol Oxidoreductases; Animals; Biopterins; Catalysis; Chromatography, High Pressure Liquid; Energy Transfer; Erythrocytes; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen Bonding; Kinetics; Liver; NADP; Oxidation-Reduction; Pteridines; Rats; Solvents; Stereoisomerism; Substrate Specificity; Tetrahydrofolate Dehydrogenase | 1985 |
Intermediates in the enzymic synthesis of tetrahydrobiopterin in Drosophila melanogaster.
Topics: Animals; Biopterins; Biotransformation; Catalysis; Drosophila melanogaster; Edetic Acid; Magnesium; NADP; Neopterin; Pteridines; Pterins | 1984 |
Two new tetrahydropterin intermediates in the adrenal medullary de novo biosynthesis of tetrahydrobiopterin.
Topics: Adrenal Medulla; Animals; Biopterins; Cattle; Chromatography, High Pressure Liquid; Electrochemistry; Kinetics; NADP; Oxidation-Reduction; Pteridines; Pterins | 1984 |
Macrophage nitric oxide synthase: tetrahydrobiopterin decreases the NADPH stoichiometry.
Topics: Amino Acid Oxidoreductases; Animals; Biopterins; Cells, Cultured; Kinetics; Macrophages; Mice; NADP; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Peroxides; Pterins | 1993 |
Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. Role of tetrahydrobiopterin in modulating the inhibitory action of nitric oxide.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Carbon Monoxide; Cerebellum; Citrulline; Cyanides; Heme; NADP; Neurons; Nitric Oxide; Nitric Oxide Synthase; Oxidants; Oxyhemoglobins; Rats; Sulfhydryl Compounds; Superoxide Dismutase | 1994 |
A bacterial nitric oxide synthase from a Nocardia species.
Topics: Amino Acid Oxidoreductases; Arginine; Biopterins; Calcium; Citrulline; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nocardia; Oxygen | 1994 |
Tumor cells suppress cytokine-induced nitric-oxide (NO) production in cerebral endothelial cells.
Topics: Amino Acid Oxidoreductases; Animals; Biopterins; Brain; Cell Adhesion; Cell Line; Colforsin; Colonic Neoplasms; Culture Media, Conditioned; Cytokines; Dexamethasone; Endothelium, Vascular; Interferon-gamma; Interleukin-1; Lipopolysaccharides; NADP; Nitric Oxide; Nitric Oxide Synthase; Rats; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1994 |
Calmodulin controls neuronal nitric-oxide synthase by a dual mechanism. Activation of intra- and interdomain electron transfer.
Topics: Amino Acid Oxidoreductases; Animals; Biopterins; Calmodulin; Catalysis; Cells, Cultured; Electron Transport; Flavins; Heme; Humans; NADP; Neurons; Nitric Oxide Synthase; Oxidation-Reduction; Rats | 1994 |
Aminoguanidine is an isoform-selective, mechanism-based inactivator of nitric oxide synthase.
Topics: Amino Acid Oxidoreductases; Animals; Biopterins; Calcium; Cattle; Cells, Cultured; Citrulline; Dose-Response Relationship, Drug; Endothelium, Vascular; Guanidines; Isoenzymes; Kinetics; Macrophages; Mice; NADP; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Oxygen; Pituitary Gland; Pulmonary Artery | 1995 |
Thiol dependence of nitric oxide synthase.
Topics: Animals; Arginine; Biopterins; Cerebellum; Citrulline; Kinetics; NADP; Nitric Oxide Synthase; Rats; Structure-Activity Relationship; Sulfhydryl Compounds; Swine | 1995 |
Multiple catalytic functions of brain nitric oxide synthase. Biochemical characterization, cofactor-requirement, and the role of N omega-hydroxy-L-arginine as an intermediate.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Brain; Catalysis; Coenzymes; Heme; Hydrolysis; Kinetics; NADP; Nitric Oxide Synthase; Oxidation-Reduction; Substrate Specificity; Swine | 1993 |
Macrophage nitric oxide synthase subunits. Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme.
Topics: Amino Acid Oxidoreductases; Animals; Biopterins; Catalysis; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Heme; Macrophages; Mice; NADP; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Oxidoreductases; Substrate Specificity | 1993 |
Sepiapterin reductase and ALR2 ("aldose reductase") from bovine brain.
Topics: Alcohol Oxidoreductases; Aldehyde Reductase; Animals; Biopterins; Brain; Cattle; In Vitro Techniques; NADP; Stereoisomerism; Substrate Specificity | 1993 |
Inducible nitric oxide synthase: identification of amino acid residues essential for dimerization and binding of tetrahydrobiopterin.
Topics: Amino Acid Sequence; Animals; Binding Sites; Biopterins; Calmodulin; Conserved Sequence; Heme; Mice; Molecular Sequence Data; Mutagenesis; NADP; Nitric Oxide Synthase; Polymerase Chain Reaction; Protein Binding; Protein Conformation; Recombinant Proteins; Sequence Homology, Amino Acid; Structure-Activity Relationship | 1995 |
Conditions required for the measurement of nitric oxide synthase activity in a myenteric plexus/smooth muscle preparation from the rat ileum.
Topics: Animals; Antioxidants; Arginine; Biopterins; Calcium; Calmodulin; Citrulline; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Ileum; In Vitro Techniques; Muscle, Smooth; Myenteric Plexus; NADP; Nitric Oxide Synthase; Rats; Rats, Wistar | 1995 |
Reduction of quinonoid dihydrobiopterin to tetrahydrobiopterin by nitric oxide synthase.
Topics: Animals; Arginine; Biopterins; Cell Line; Cerebellum; Enzyme Inhibitors; Humans; Indazoles; Kidney; Kinetics; Methotrexate; NADP; Nitric Oxide Synthase; Nitroarginine; Onium Compounds; Oxidation-Reduction; Rats; Recombinant Proteins; Transfection | 1996 |
Calcium-dependent nitric oxide synthesis is potently stimulated by tetrahydrobiopterin in human primordial placenta.
Topics: Arginine; Biopterins; Calcium; Citrulline; Enzyme Activation; Female; Humans; NADP; Nitric Oxide; Nitric Oxide Synthase; Placenta; Pregnancy | 1996 |
Biochemical and immunohistochemical characterization of nitric oxide synthase in the rat retina.
Topics: Animals; Biopterins; Blotting, Western; Cross Reactions; Enzyme Inhibitors; Female; Flavin-Adenine Dinucleotide; Imidazoles; Immunohistochemistry; Male; NADP; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Retina | 1996 |
Thiols and neuronal nitric oxide synthase: complex formation, competitive inhibition, and enzyme stabilization.
Topics: Animals; Arginine; Biopterins; Calmodulin; Cysteine; Dithiothreitol; Enzyme Inhibitors; Enzyme Stability; Flavin-Adenine Dinucleotide; Heme; Mercaptoethanol; NADP; Neurons; Nitric Oxide Synthase; Protein Binding; Rats; Spectrometry, Fluorescence; Spectrophotometry; Sulfhydryl Compounds; Temperature | 1997 |
Tetrahydrobiopterin regulates superoxide and nitric oxide generation by recombinant endothelial nitric oxide synthase.
Topics: Animals; Baculoviridae; Biopterins; Calcium; Calmodulin; Cattle; Cell Line; NADP; Nitric Oxide; Nitric Oxide Synthase; Recombinant Proteins; Spodoptera; Superoxides | 1997 |
Nicotinamide inhibits inducible nitric oxide synthase enzyme activity in macrophages by allowing nitric oxide to inhibit its own formation.
Topics: Animals; Biopterins; Citrulline; Female; Hemoglobins; Macrophages, Peritoneal; Male; Mice; NADP; Niacinamide; Nitric Oxide; Nitric Oxide Synthase; RNA, Messenger | 1997 |
Nitric oxide synthase activity in tissues of the bovine eye.
Topics: Animals; Antioxidants; Biopterins; Calmodulin; Canavanine; Cattle; Chelating Agents; Choroid; Ciliary Body; Edetic Acid; Enzyme Inhibitors; Female; Guanidines; Male; NADP; Nitric Oxide Synthase; omega-N-Methylarginine; Retina; Trabecular Meshwork | 1997 |
Electron transfer and catalytic activity of nitric oxide synthases. Chimeric constructs of the neuronal, inducible, and endothelial isoforms.
Topics: Animals; Arginine; Biopterins; Calmodulin; Cattle; Cytochrome c Group; Dimerization; Egtazic Acid; Electron Transport; Isoenzymes; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Recombinant Fusion Proteins; Recombinant Proteins; Sequence Homology, Amino Acid | 1998 |
Effects of pH on the structure and function of neuronal nitric oxide synthase.
Topics: Animals; Arginine; Biopterins; Brain; Citrulline; Dimerization; Heme; Hydrogen Peroxide; Hydrogen-Ion Concentration; NADP; Nerve Tissue Proteins; Nitric Oxide Synthase; Protein Binding; Protein Conformation; Rats; Spectrophotometry | 1998 |
Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors.
Topics: Animals; Arginine; Biopterins; Calcium; Calmodulin; Cattle; Electron Spin Resonance Spectroscopy; NADP; NADPH Oxidases; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Spin Labels; Superoxides | 1998 |
Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process.
Topics: Arginine; Biopterins; Calcium; Calmodulin; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Free Radicals; Humans; NADP; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Recombinant Proteins; Sodium Cyanide; Spin Labels; Stereoisomerism; Superoxides | 1998 |
Reactions catalyzed by tetrahydrobiopterin-free nitric oxide synthase.
Topics: Amino Acids; Animals; Arginine; Biopterins; Carbon Monoxide; Catalase; Catalysis; Chromatography, Gel; Enzyme Induction; Escherichia coli; Macrophages; Mice; NADP; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Recombinant Proteins; Spectrophotometry, Ultraviolet | 1998 |
The C331A mutant of neuronal nitric-oxide synthase is defective in arginine binding.
Topics: Animals; Arginine; Biopterins; Calmodulin; Carbon Monoxide; Catalytic Domain; Conserved Sequence; Cysteine; Electron Spin Resonance Spectroscopy; Escherichia coli; Heme; Mutation; NADP; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction; Rats; Recombinant Proteins; Spectrophotometry; Structure-Activity Relationship | 1998 |
Efficient formation of nitric oxide from selective oxidation of N-aryl N'-hydroxyguanidines by inducible nitric oxide synthase.
Topics: Biopterins; Catalysis; Guanidines; Hydroxylamines; Kinetics; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxygen; Urea | 1999 |
Tetrahydrobiopterin-dependent inhibition of superoxide generation from neuronal nitric oxide synthase.
Topics: Animals; Arginine; Biopterins; Cattle; Citrulline; Electron Spin Resonance Spectroscopy; Models, Chemical; NADP; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxygen; Superoxides | 1999 |
Aromatic residues and neighboring Arg414 in the (6R)-5,6,7, 8-tetrahydro-L-biopterin binding site of full-length neuronal nitric-oxide synthase are crucial in catalysis and heme reduction with NADPH.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Binding Sites; Biopterins; Catalysis; Dimerization; Drosophila; Glutamine; Heme; Humans; Hydrogen Bonding; Leucine; Mice; Models, Molecular; Molecular Sequence Data; NADP; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction; Phenylalanine; Rats; Spectrophotometry, Atomic; Structure-Activity Relationship; Tryptophan | 2000 |
Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency.
Topics: Animals; Arginine; Biopterins; Calcium; Calmodulin; Chromatography, High Pressure Liquid; Diabetes Mellitus; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; GTP Cyclohydrolase; Immunoblotting; Kinetics; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Protein Isoforms; Pteridines; Pterins; Rats; Rats, Mutant Strains | 2000 |
Arginine conversion to nitroxide by tetrahydrobiopterin-free neuronal nitric-oxide synthase. Implications for mechanism.
Topics: Arginine; Biopterins; Catalysis; Citrulline; Heme; Hydrogen Peroxide; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction | 2000 |
Modulation of nitric-oxide synthase by nicotine.
Topics: Animals; Aorta, Thoracic; Arginine; Biopterins; Citrulline; Dogs; Endothelium, Vascular; Flavin-Adenine Dinucleotide; Male; NADP; Nicotine; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Recombinant Proteins | 2000 |
Oxidations of N(omega)-hydroxyarginine analogues and various N-hydroxyguanidines by NO synthase II: key role of tetrahydrobiopterin in the reaction mechanism and substrate selectivity.
Topics: Antioxidants; Arginine; Biopterins; Guanidines; Hydroxylamines; NADP; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxidation-Reduction; Substrate Specificity; Superoxide Dismutase | 2001 |
Important role of tetrahydrobiopterin in no complex formation and interdomain electron transfer in neuronal nitric-oxide synthase.
Topics: Anaerobiosis; Animals; Antioxidants; Arginine; Biopterins; Calcium; Calmodulin; Catalysis; Iron; Macromolecular Substances; Models, Chemical; Mutagenesis, Site-Directed; NADP; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction; Rats; Spectrophotometry | 2001 |
Citrulline is not the major product using the standard "NOS activity" assay on renal cortical homogenates.
Topics: Animals; Antioxidants; Arginine; Biopterins; Calcium; Carbon Radioisotopes; Chelating Agents; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Citrulline; Egtazic Acid; Enzyme Inhibitors; Female; Guanidines; Humans; Kidney Cortex; Male; Mice; Mice, Inbred Strains; NADP; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; omega-N-Methylarginine; Placenta; Rats; Rats, Long-Evans; Tritium | 2002 |
Cloning, expression, and characterization of a nitric oxide synthase protein from Deinococcus radiodurans.
Topics: Amino Acid Sequence; Animals; Arginine; Biopterins; Catalysis; Citrulline; Cloning, Molecular; Dimerization; Dithiothreitol; Dose-Response Relationship, Drug; Electrons; Heme; Hydrogen Peroxide; Kinetics; Ligands; Models, Chemical; Models, Molecular; Molecular Sequence Data; NADP; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Thermus; Time Factors; Zinc | 2002 |
Glucose deprivation decreases nitric oxide production via NADPH depletion in immunostimulated rat primary astrocytes.
Topics: Adjuvants, Immunologic; Animals; Animals, Newborn; Astrocytes; Biopterins; Cell Death; Cells, Cultured; Central Nervous System; Deoxyglucose; Down-Regulation; Glucose; Glutathione; Interferon-gamma; Lactic Acid; Lipopolysaccharides; NADP; Neurodegenerative Diseases; Nitric Oxide; Nitric Oxide Synthase; Pyruvic Acid; Rats; Rats, Sprague-Dawley | 2002 |
Expression and activity of nitric oxide synthase isoforms in rat brain during the development of experimental allergic encephalomyelitis.
Topics: Animals; Biopterins; Brain; Calcium; Calmodulin; Disease Models, Animal; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Female; Flavin-Adenine Dinucleotide; Male; NADP; Neurons; Nitric Oxide; Nitric Oxide Synthase; Protein Isoforms; Rats; Rats, Inbred Lew; RNA, Messenger; Subcellular Fractions; Tyrosine | 2002 |
Regulation of endothelial cell proliferation by nitric oxide.
Topics: Animals; Biopterins; Blotting, Western; Cell Division; Coloring Agents; Coronary Vessels; Endothelium, Vascular; GTP Cyclohydrolase; Humans; Muscle, Skeletal; NADP; Nitric Oxide; Proliferating Cell Nuclear Antigen; Rats; Tetrazolium Salts; Thiazoles; Thymidine; Time Factors | 2002 |
The role of tetrahydrobiopterin in the regulation of neuronal nitric-oxide synthase-generated superoxide.
Topics: Biopterins; Hydrogen Peroxide; NADP; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxygen; Superoxides | 2002 |
Characterization of Drosophila nitric oxide synthase: a biochemical study.
Topics: Animals; Arginine; Biopterins; Dose-Response Relationship, Drug; Drosophila; Electrons; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Heme; Hydrogen Peroxide; Hydrolysis; NADP; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Open Reading Frames; Protein Structure, Tertiary; Spectrophotometry; Time Factors; Trypsin; Ultraviolet Rays; Urea | 2003 |
A tryptophan that modulates tetrahydrobiopterin-dependent electron transfer in nitric oxide synthase regulates enzyme catalysis by additional mechanisms.
Topics: Animals; Arginine; Biopterins; Catalysis; Dimerization; Electron Transport; Enzyme Stability; Ferrous Compounds; Heme; Hydroxylation; Isoenzymes; Kinetics; Mice; Mutagenesis, Site-Directed; NADP; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Oxidation-Reduction; Protein Binding; Rats; Spectrophotometry; Tryptophan | 2005 |
Structure of Chlorobium tepidum sepiapterin reductase complex reveals the novel substrate binding mode for stereospecific production of L-threo-tetrahydrobiopterin.
Topics: Alcohol Oxidoreductases; Animals; Binding Sites; Biopterins; Catalytic Domain; Chlorobium; Cloning, Molecular; Crystallography, X-Ray; Escherichia coli; Mice; Models, Chemical; Models, Molecular; Molecular Sequence Data; NADP; Protein Binding; Protein Conformation; Protein Folding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Stereoisomerism | 2006 |
Hydrogen sulfide inhibits activity of three isoforms of recombinant nitric oxide synthase.
Topics: Air Pollutants; Biopterins; Cysteine; Dithiothreitol; Enzyme Inhibitors; Humans; Hydrogen Sulfide; NADP; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Recombinant Proteins; Sulfates | 2007 |
Regulation of eNOS-derived superoxide by endogenous methylarginines.
Topics: Arginine; Biopterins; Electron Spin Resonance Spectroscopy; Heme; Humans; NADP; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Superoxides | 2008 |
Dietary supplementation with cholesterol and docosahexaenoic acid increases the activity of the arginine-nitric oxide pathway in tissues of young pigs.
Topics: Analysis of Variance; Animals; Animals, Newborn; Arginine; Biopterins; Blotting, Western; Brain; Cholesterol, Dietary; Chromatography, High Pressure Liquid; Citrulline; Dietary Supplements; Docosahexaenoic Acids; GTP Cyclohydrolase; Liver; Muscle, Skeletal; NADP; Nitric Oxide; Nitric Oxide Synthase; Swine | 2008 |
Tetrahydrobiopterin biosynthesis as an off-target of sulfa drugs.
Topics: 5-Hydroxytryptophan; Adult; Alcohol Oxidoreductases; Anti-Infective Agents; Biopterins; Cell Line; Central Nervous System; Crystallography, X-Ray; Fibroblasts; Humans; Levodopa; NADP; Nausea; Pneumonia, Pneumocystis; Protein Conformation; Structure-Activity Relationship; Sulfamethoxazole; Trimethoprim, Sulfamethoxazole Drug Combination; Vomiting | 2013 |
Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart.
Topics: ADP-ribosyl Cyclase 1; Animals; Biopterins; Coronary Artery Disease; Electron Spin Resonance Spectroscopy; Endothelium, Vascular; Heart; Hypoxia; Ischemia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NADP; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Reperfusion Injury; RNA, Small Interfering | 2015 |
Serine 1179 Phosphorylation of Endothelial Nitric Oxide Synthase Increases Superoxide Generation and Alters Cofactor Regulation.
Topics: Animals; Arginine; Biopterins; Calcium; Calmodulin; Cattle; Cell Survival; Citrulline; Electron Spin Resonance Spectroscopy; Endothelium, Vascular; HEK293 Cells; Humans; Mutation; NADP; Nitric Oxide Synthase Type III; Oxygen; Phosphorylation; Reactive Oxygen Species; Recombinant Proteins; Serine; Spin Trapping; Superoxides; Vascular Endothelial Growth Factor A | 2015 |
Theoretical studies of the second step of the nitric oxide synthase reaction: Electron tunneling prevents uncoupling.
Topics: Animals; Arginine; Biocatalysis; Biopterins; Catalytic Domain; Citrulline; Conserved Sequence; Databases, Protein; Electron Transport; Humans; Hydrogen Bonding; Models, Molecular; NADP; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidation-Reduction; Protons; Quantum Theory; Thermodynamics | 2018 |