sapropterin and heme
sapropterin has been researched along with heme in 84 studies
Research
Studies (84)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 39 (46.43) | 18.2507 |
| 2000's | 37 (44.05) | 29.6817 |
| 2010's | 8 (9.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Fukuto, JM; Griscavage, JM; Ignarro, LJ; Komori, Y | 1 |
| Abu-Soud, HM; Stuehr, DJ; Yoho, LL | 1 |
| Ghosh, DK; Stuehr, DJ | 1 |
| Rousseau, DL; Stuehr, DJ; Wang, J | 1 |
| Klatt, P; Mayer, B; Schmidt, K; Uray, G | 1 |
| Baek, KJ; Lucas, S; Stuehr, DJ; Thiel, BA | 1 |
| Cho, HJ; Martin, E; Nathan, C; Sassa, S; Xie, QW | 1 |
| Albakri, QA; Stuehr, DJ | 1 |
| Gerber, NC; Ortiz de Montellano, PR; Rodríguez-Crespo, I | 1 |
| Bächinger, HP; Glatter, O; Klatt, P; Lehner, D; List, BM; Mayer, B; Pfeiffer, S; Schmidt, K; Werner, ER | 1 |
| Boyhan, A; Charles, I; Lowe, PN; Moncada, S; Riveros-Moreno, V; Smith, D; Stammers, DK | 1 |
| Klatt, P; List, BM; Mayer, B; Schmidt, K; Werner, ER | 1 |
| Klatt, P; Mayer, B; Schmidt, K; Werner, ER | 1 |
| Gorren, AC; Hemmens, B; List, BM; Mayer, B; Pitters, E; Schmidt, K; Schrammel, A; Werner, ER | 1 |
| Gorren, AC; Mayer, B; Schmidt, K; Schrammel, A | 2 |
| Stuehr, DJ | 1 |
| Crane, BR; Gachhui, R; Ghosh, DK; Parkinson, J; Stuehr, DJ; Wu, C | 1 |
| Boyhan, A; Charles, IG; Lowe, PN; Saqi, M; Smith, D | 1 |
| Alderton, WK; Boyhan, A; Charles, IG; Cubberley, RR; Lowe, PN; Old, RW | 1 |
| Gorren, AC; Klösch, B; Kukovetz, WR; List, BM; Mayer, B; Schmidt, K; Sessa, WC; Völker, C; Werner, ER | 1 |
| Clark, P; Gorren, AC; Mayer, B; Pfeiffer, S; Schmidt, K; Stuehr, DJ; Werner, ER; Wu, C | 1 |
| Abu-Soud, HM; Gachhui, R; Raushel, FM; Stuehr, DJ | 1 |
| Arvai, AS; Crane, BR; Gachhui, R; Getzoff, ED; Ghosh, DK; Stuehr, DJ; Tainer, JA; Wu, C | 1 |
| Alderton, WK; Boyhan, A; Lowe, PN | 1 |
| Gorren, AC; Hemmens, B; Mayer, B; Schmidt, K; Werner, ER | 1 |
| Daff, S; Nakano, K; Sagami, I; Shimizu, T | 1 |
| Hurshman, AR; Marletta, MA; Rusche, KM | 1 |
| Gross, SS; Ikeda-Saito, M; Liu, Q; Martásek, P; Masters, BS; Migita, CT; Miller, RT; Raman, CS; Roman, LJ; Salerno, JC | 1 |
| Andrew, PJ; Brunner, K; Hemmens, B; Kungl, AJ; Mayer, B; Tortschanoff, A | 1 |
| Král, V; Li, H; Martásek, P; Masters, BS; Poulos, TL; Raman, CS | 1 |
| Alderton, WK; Lowe, PN | 1 |
| Abu-Soud, HM; Hille, R; Huang, L; Stuehr, DJ | 1 |
| Dolphin, E; Fischmann, TO; Fossetta, JD; Hruza, A; Lundell, DJ; Lunn, CA; Narula, SK; Niu, XD; Prongay, AJ; Reichert, P; Weber, PC | 1 |
| Boyington, JC; Kulansky, R; Malech, HL; Rafferty, SP; Sun, PD | 1 |
| Li, H; Poulos, TL; Raman, CS | 1 |
| Berka, V; Lambry, JC; Liebl, U; Martin, JL; Négrerie, M; Tsai, AL; Vos, MH | 1 |
| Edmondson, DE; Hurshman, AR; Huynh, BH; Krebs, C; Marletta, MA | 1 |
| Andrew, PJ; Mayer, B | 1 |
| Arvai, AS; Crane, BR; Getzoff, ED; Ghosh, S; Stuehr, DJ; Tainer, JA | 1 |
| Daff, S; Sagami, I; Sato, Y; Shimizu, T | 1 |
| Berka, V; Tsai, AL | 1 |
| Adak, S; Stuehr, DJ; Wang, Q | 1 |
| Hemann, C; Hille, R; Meade, AL; Stuehr, DJ; Wang, Q; Wang, ZQ; Wei, CC | 1 |
| Marletta, MA; Rusche, KM | 1 |
| d'Ischia, M; Palumbo, A | 1 |
| Cosper, NJ; Hori, H; Iwasaki, T; Nishino, T; Scott, RA | 1 |
| Ghosh, S; Hemann, C; Hille, R; Meade, AL; Stuehr, DJ; Wang, ZQ; Wei, CC | 1 |
| Aoyagi, M; Arvai, AS; Getzoff, ED; Ghosh, S; Stuehr, DJ; Tainer, JA | 1 |
| Berka, V; Lambry, JC; Martin, JL; Négrerie, M; Slama-Schwok, A; Tsai, AL; Vos, MH | 1 |
| Adak, S; Aulak, KS; Bilwes, AM; Crane, BR; Getzoff, ED; Hosfield, D; McDonald, JF; Panda, K; Stuehr, DJ; Tainer, JA | 1 |
| Hurshman, AR; Marletta, MA | 1 |
| Gorren, AC; Mayer, B; Schmidt, K | 1 |
| Marks, N; Wolff, DJ | 1 |
| Arvai, AS; Getzoff, ED; Hemann, C; Hille, R; Stuehr, DJ; Wang, ZQ; Wei, CC | 1 |
| Boucher, JL; Desbois, A; Frapart, Y; Gorren, AC; Lefèvre-Groboillot, D; Mansuy, D; Mayer, B; Stuehr, DJ; Zimmermann, JL | 1 |
| Ghosh, S; Mukherjee, S; Regulski, M; Sahoo, R; Sengupta, R; Stuehr, DJ; Tully, T | 1 |
| Sagami, I; Sato, Y; Shimizu, T | 1 |
| Collin, F; Gautier, C; Lambry, JC; Martin, JL; Négrerie, M; Slama-Schwok, A; Stuehr, DJ; Wang, ZQ | 1 |
| Edmondson, DE; Hurshman, AR; Krebs, C; Marletta, MA | 1 |
| Berka, V; Palmer, G; Tsai, AL; Wu, G; Yeh, HC | 1 |
| Araki, Y; Bengea, S; Igarashi, J; Ito, O; Sagami, I; Shimizu, T | 1 |
| Andersson, KK; Gorren, AC; Lange, R; Marchal, S; Mayer, B; Sørlie, M | 1 |
| Berka, V; Gao, D; Kiran, F; Tsai, AL; Yeh, HC | 1 |
| Durra, D; Garcin, ED; Getzoff, ED; Hemann, C; Hille, R; Stuehr, DJ; Wang, ZQ; Wei, CC | 1 |
| Panda, K; Santolini, J; Stuehr, DJ; Wang, Q; Wang, ZQ; Wei, CC | 1 |
| Dunbar, AY; Jenkins, GJ; Kamada, Y; Lau, M; Lowe, ER; Osawa, Y | 1 |
| Hille, R; Stuehr, DJ; Wang, Z; Wei, CC | 1 |
| Boucher, JL; Lefèvre-Groboillot, D; Mansuy, D; Stuehr, DJ | 1 |
| Dasgupta, A; Dutta, T; Ghosh, S; Ray, SS; Sahoo, R; Sengupta, R | 1 |
| Deng, H; Hayden, EY; Li, D; Panda, K; Rousseau, DL; Stuehr, DJ; Yeh, SR | 1 |
| Hillier, IH; Joule, JA; Morao, I; Periyasamy, G | 1 |
| Bhattacharjee, A; Dutta, T; Ghosh, S; Ray, SS; Regulski, M; Stuehr, DJ; Tejero, J; Tully, T; Wang, ZQ | 1 |
| Cardounel, AJ; Chen, CA; Druhan, LJ; Forbes, SP; Pope, AJ; Zweier, JL | 1 |
| Biswas, A; Haque, MM; Hemann, C; Misra, S; Page, RC; Stuehr, DJ; Tejero, J; Wang, ZQ; Zweier, JL | 1 |
| Menyhárd, DK | 1 |
| Berka, V; Chen, CA; Chen, W; Chen, YR; Druhan, LJ; Hemann, C; Tsai, AL; Zweier, JL | 1 |
| Boucher, JL; Mansuy, D; Salard-Arnaud, I; Stuehr, D | 1 |
| Gorren, AC; Kolesnik, B; Mayer, B; Neubauer, A; Schmidt, K; Stasch, JP; Werner, ER | 1 |
| Stuehr, D; Tejero, J | 1 |
| Ghosh, A; Haque, MM; Mukherjee, N; Nagpal, L; Panda, K; Ranu, BC; Saha, A; Stuehr, DJ | 1 |
| Chreifi, G; Kang, S; Li, H; Martásek, P; Poulos, TL; Roman, LJ; Silverman, RB; Tang, W | 1 |
| Gangoda, M; Haque, MM; Ramasamy, S; Stuehr, DJ | 1 |
| Berka, V; Bowman, MK; Cruce, AA; Krzyaniak, MD; Lockart, M; Tsai, AL; Vennam, P | 1 |
Reviews
7 review(s) available for sapropterin and heme
| Article | Year |
|---|---|
Structure-function aspects in the nitric oxide synthases.
Topics: Binding Sites; Biopterins; Catalysis; Dimerization; Heme; Humans; Models, Chemical; Models, Structural; Nitric Oxide Synthase; Protein Folding; Structure-Activity Relationship | 1997 |
Catalysis by nitric oxide synthase.
Topics: Antioxidants; Arginine; Biopterins; Catalysis; Citrulline; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Heme; Hydrogen Peroxide; Isoenzymes; Nitric Oxide; Nitric Oxide Synthase | 1998 |
Scintillation proximity assay to measure nitroarginine and tetrahydrobiopterin binding to heme domain of neuronal nitric oxide synthase.
Topics: Animals; Biological Assay; Biopterins; Heme; Humans; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroarginine; Protein Binding | 1999 |
Heme-mediated oxygen activation in biology: cytochrome c oxidase and nitric oxide synthase.
Topics: Animals; Biopterins; Dimerization; Electron Transport Complex IV; Heme; Nitric Oxide Synthase; Oxygen; Protein Conformation; Proton Pumps | 1999 |
Enzymatic function of nitric oxide synthases.
Topics: Animals; Antioxidants; Arginine; Biopterins; Calcium; Calmodulin; Dimerization; Endothelium, Vascular; Enzyme Activation; Heme; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III | 1999 |
[Structure-function relationships of NO synthase: electron transfer reaction].
Topics: Animals; Arginine; Binding Sites; Biopterins; Calmodulin; Crystallization; Electron Transport; Heme; Humans; Iron; Nitric Oxide; Nitric Oxide Synthase; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Structure-Activity Relationship; Sulfhydryl Compounds | 2003 |
Tetrahydrobiopterin in nitric oxide synthase.
Topics: Amino Acid Oxidoreductases; Arginine; Biopterins; Catalysis; Heme; Nitric Oxide; Nitric Oxide Synthase | 2013 |
Other Studies
77 other study(ies) available for sapropterin and heme
| Article | Year |
|---|---|
Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. Role of tetrahydrobiopterin in modulating the inhibitory action of nitric oxide.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Carbon Monoxide; Cerebellum; Citrulline; Cyanides; Heme; NADP; Neurons; Nitric Oxide; Nitric Oxide Synthase; Oxidants; Oxyhemoglobins; Rats; Sulfhydryl Compounds; Superoxide Dismutase | 1994 |
Calmodulin controls neuronal nitric-oxide synthase by a dual mechanism. Activation of intra- and interdomain electron transfer.
Topics: Amino Acid Oxidoreductases; Animals; Biopterins; Calmodulin; Catalysis; Cells, Cultured; Electron Transport; Flavins; Heme; Humans; NADP; Neurons; Nitric Oxide Synthase; Oxidation-Reduction; Rats | 1994 |
Macrophage NO synthase: characterization of isolated oxygenase and reductase domains reveals a head-to-head subunit interaction.
Topics: Amino Acid Oxidoreductases; Amino Acid Sequence; Animals; Biopterins; Calmodulin; Catalysis; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Heme; Macrophages; Mice; Molecular Sequence Data; Molecular Weight; Nitric Oxide Synthase; Peptide Fragments; Protein Conformation; Spectrum Analysis; Structure-Activity Relationship; Trypsin | 1995 |
Tetrahydrobiopterin-deficient nitric oxide synthase has a modified heme environment and forms a cytochrome P-420 analogue.
Topics: Amino Acid Oxidoreductases; Animals; Biopterins; Cell Line; Cytochromes; Heme; Mice; Neurons; Nitric Oxide Synthase; Spectrum Analysis, Raman | 1995 |
Multiple catalytic functions of brain nitric oxide synthase. Biochemical characterization, cofactor-requirement, and the role of N omega-hydroxy-L-arginine as an intermediate.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Biopterins; Brain; Catalysis; Coenzymes; Heme; Hydrolysis; Kinetics; NADP; Nitric Oxide Synthase; Oxidation-Reduction; Substrate Specificity; Swine | 1993 |
Macrophage nitric oxide synthase subunits. Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme.
Topics: Amino Acid Oxidoreductases; Animals; Biopterins; Catalysis; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Heme; Macrophages; Mice; NADP; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Oxidoreductases; Substrate Specificity | 1993 |
Inducible nitric oxide synthase: identification of amino acid residues essential for dimerization and binding of tetrahydrobiopterin.
Topics: Amino Acid Sequence; Animals; Binding Sites; Biopterins; Calmodulin; Conserved Sequence; Heme; Mice; Molecular Sequence Data; Mutagenesis; NADP; Nitric Oxide Synthase; Polymerase Chain Reaction; Protein Binding; Protein Conformation; Recombinant Proteins; Sequence Homology, Amino Acid; Structure-Activity Relationship | 1995 |
Intracellular assembly of inducible NO synthase is limited by nitric oxide-mediated changes in heme insertion and availability.
Topics: Aminolevulinic Acid; Animals; Arginine; Biopterins; Cell Line; Cytokines; Enzyme Induction; Enzyme Inhibitors; Heme; Homeostasis; Interferon-gamma; Iron; Isoenzymes; Kinetics; Lipopolysaccharides; Macromolecular Substances; Macrophage Activation; Macrophages; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Recombinant Proteins; Time Factors | 1996 |
Endothelial nitric-oxide synthase. Expression in Escherichia coli, spectroscopic characterization, and role of tetrahydrobiopterin in dimer formation.
Topics: Animals; Arginine; Biopterins; Cattle; Chromatography, Affinity; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Heme; Histidine; Kinetics; Macromolecular Substances; Molecular Weight; Nitric Oxide Synthase; Protein Denaturation; Recombinant Proteins; Restriction Mapping; Sequence Tagged Sites; Spectrophotometry; Substrate Specificity | 1996 |
Characterization of heme-deficient neuronal nitric-oxide synthase reveals a role for heme in subunit dimerization and binding of the amino acid substrate and tetrahydrobiopterin.
Topics: Animals; Arginine; Binding Sites; Biopterins; Brain; Chromatography, Gel; Circular Dichroism; Citrulline; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Heme; Isoenzymes; Light; Macromolecular Substances; Neurons; Nitric Oxide Synthase; Nitroarginine; Protein Conformation; Protein Structure, Secondary; Rats; Scattering, Radiation; Thermodynamics | 1996 |
Identification of the domains of neuronal nitric oxide synthase by limited proteolysis.
Topics: Amino Acid Sequence; Animals; Arginine; Binding Sites; Biopterins; Blotting, Western; Brain; Calmodulin; Chymotrypsin; Cytochrome c Group; Electrophoresis, Polyacrylamide Gel; Flavin Mononucleotide; Heme; Humans; Molecular Sequence Data; Molecular Weight; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Rabbits; Rats; Recombinant Proteins; Trypsin | 1996 |
Overexpression of neuronal nitric oxide synthase in insect cells reveals requirement of haem for tetrahydrobiopterin binding.
Topics: Animals; Arginine; Baculoviridae; Biopterins; Brain; Citrulline; Culture Media; Flavins; Heme; Kinetics; Neurons; Nitric Oxide Synthase; Protein Processing, Post-Translational; Rats; Recombinant Proteins; Spodoptera; Tritium | 1996 |
Determination of nitric oxide synthase cofactors: heme, FAD, FMN, and tetrahydrobiopterin.
Topics: Animals; Baculoviridae; Biopterins; Brain; Cell Line; Chromatography, High Pressure Liquid; Coenzymes; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Heme; Nitric Oxide Synthase; Rats; Recombinant Proteins; Spectrophotometry; Spodoptera; Transfection | 1996 |
Tetrahydrobiopterin-free neuronal nitric oxide synthase: evidence for two identical highly anticooperative pteridine binding sites.
Topics: Animals; Binding Sites; Biopterins; Dimerization; Heme; In Vitro Techniques; Kinetics; Molecular Structure; Neurons; Nitric Oxide Synthase; Oxidation-Reduction; Protein Conformation; Pteridines; Rats; Recombinant Proteins; Spectrophotometry | 1996 |
Thiols and neuronal nitric oxide synthase: complex formation, competitive inhibition, and enzyme stabilization.
Topics: Animals; Arginine; Biopterins; Calmodulin; Cysteine; Dithiothreitol; Enzyme Inhibitors; Enzyme Stability; Flavin-Adenine Dinucleotide; Heme; Mercaptoethanol; NADP; Neurons; Nitric Oxide Synthase; Protein Binding; Rats; Spectrometry, Fluorescence; Spectrophotometry; Sulfhydryl Compounds; Temperature | 1997 |
Mutagenesis of acidic residues in the oxygenase domain of inducible nitric-oxide synthase identifies a glutamate involved in arginine binding.
Topics: Alanine; Amino Acid Sequence; Animals; Antioxidants; Arginine; Biopterins; Cattle; Chromatography, Gel; Glutamic Acid; Heme; Humans; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Nitric Oxide Synthase; Oxygenases; Rats; Structure-Activity Relationship | 1997 |
Delineation of the arginine- and tetrahydrobiopterin-binding sites of neuronal nitric oxide synthase.
Topics: Amino Acid Sequence; Animals; Antioxidants; Arginine; Binding Sites; Biopterins; Calorimetry; Escherichia coli; Heme; Humans; Mice; Molecular Sequence Data; Neurons; Nitric Oxide Synthase; Peptide Mapping; Rats; Sequence Alignment; Structure-Activity Relationship | 1997 |
Cysteine-200 of human inducible nitric oxide synthase is essential for dimerization of haem domains and for binding of haem, nitroarginine and tetrahydrobiopterin.
Topics: Animals; Antioxidants; Binding Sites; Biopterins; Cysteine; Dimerization; DNA; Enzyme Induction; Heme; Humans; Nitric Oxide Synthase; Nitroarginine; Protein Conformation; Recombinant Fusion Proteins; Xenopus | 1997 |
Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerization.
Topics: Animals; Antioxidants; Biopterins; Cattle; Dimerization; Endothelium, Vascular; Heme; Kinetics; Molecular Weight; NADPH Oxidases; Nitric Oxide Synthase; Protein Conformation; Spectrophotometry, Atomic; Spodoptera | 1997 |
Tetrahydrobiopterin binding to macrophage inducible nitric oxide synthase: heme spin shift and dimer stabilization by the potent pterin antagonist 4-amino-tetrahydrobiopterin.
Topics: Animals; Biopterins; Dimerization; Electrophoresis, Polyacrylamide Gel; Heme; Kinetics; Macrophages; Mice; Nitric Oxide Synthase; Pteridines; Recombinant Proteins; Spectrophotometry | 1997 |
The ferrous-dioxy complex of neuronal nitric oxide synthase. Divergent effects of L-arginine and tetrahydrobiopterin on its stability.
Topics: Animals; Arginine; Biopterins; Catalysis; Enzyme Stability; Ferrous Compounds; Heme; Models, Chemical; Neurons; Nitric Oxide Synthase; Oxygen; Rats; Spectrophotometry, Atomic | 1997 |
The structure of nitric oxide synthase oxygenase domain and inhibitor complexes.
Topics: Amino Acid Sequence; Arginine; Binding Sites; Biopterins; Caenorhabditis elegans Proteins; Catalysis; Crystallography, X-Ray; Dimerization; Enzyme Induction; Enzyme Inhibitors; Guanidines; Heme; Homeodomain Proteins; Hydrogen Bonding; Imidazoles; Isoenzymes; Models, Molecular; Molecular Sequence Data; Nitric Oxide Synthase; Oxidation-Reduction; Oxygen; Oxygenases; Protein Conformation; Protein Folding; Protein Structure, Secondary | 1997 |
Effects of pH on the structure and function of neuronal nitric oxide synthase.
Topics: Animals; Arginine; Biopterins; Brain; Citrulline; Dimerization; Heme; Hydrogen Peroxide; Hydrogen-Ion Concentration; NADP; Nerve Tissue Proteins; Nitric Oxide Synthase; Protein Binding; Protein Conformation; Rats; Spectrophotometry | 1998 |
Nitroarginine and tetrahydrobiopterin binding to the haem domain of neuronal nitric oxide synthase using a scintillation proximity assay.
Topics: Animals; Arginine; Binding Sites; Binding, Competitive; Biopterins; Enzyme Inhibitors; Heme; Indazoles; Isothiuronium; Kinetics; Nitric Oxide Synthase; Nitroarginine; Oxidoreductases; Oxygenases; Peptide Fragments; Protein Binding; Rats; Recombinant Fusion Proteins | 1998 |
Haem insertion, dimerization and reactivation of haem-free rat neuronal nitric oxide synthase.
Topics: Animals; Baculoviridae; Binding Sites; Biopterins; Cross-Linking Reagents; Dimerization; Enzyme Activation; Flavoproteins; Glutaral; Heme; Manganese; Nitric Oxide Synthase; Nitroarginine; Porphyrins; Rats; Recombinant Proteins; Spectrometry, Fluorescence; Spectrophotometry | 1998 |
Chiral recognition at the heme active site of nitric oxide synthase is markedly enhanced by L-arginine and 5,6,7,8-tetrahydrobiopterin.
Topics: Anaerobiosis; Animals; Antioxidants; Arginine; Binding Sites; Biopterins; Calmodulin; Cloning, Molecular; Heme; Kinetics; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Recombinant Proteins; Saccharomyces cerevisiae; Spectrophotometry; Stereoisomerism | 1998 |
The C331A mutant of neuronal nitric-oxide synthase is defective in arginine binding.
Topics: Animals; Arginine; Biopterins; Calmodulin; Carbon Monoxide; Catalytic Domain; Conserved Sequence; Cysteine; Electron Spin Resonance Spectroscopy; Escherichia coli; Heme; Mutation; NADP; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction; Rats; Recombinant Proteins; Spectrophotometry; Structure-Activity Relationship | 1998 |
Sensitivity of flavin fluorescence dynamics in neuronal nitric oxide synthase to cofactor-induced conformational changes and dimerization.
Topics: Animals; Arginine; Biopterins; Brain; Calmodulin; Dimerization; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Flavins; Fluorescence Polarization; Heme; Holoenzymes; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Protein Binding; Protein Conformation; Rats; Spectrometry, Fluorescence; Substrate Specificity; Thermodynamics | 1998 |
Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center.
Topics: Amino Acid Sequence; Animals; Binding Sites; Biopterins; Catalysis; Cations; Cattle; Crystallization; Crystallography, X-Ray; Cysteine; Dimerization; Heme; Hydrogen Bonding; Models, Molecular; Molecular Mimicry; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Protein Structure, Secondary; Pterins; Sequence Alignment; Zinc | 1998 |
Nitric oxide-generated P420 nitric oxide synthase: characterization and roles for tetrahydrobiopterin and substrate in protecting against or reversing the P420 conversion.
Topics: Air; Biopterins; Catalysis; Cytochromes; Electron Spin Resonance Spectroscopy; Enzyme Activation; Ferrous Compounds; Heme; Kinetics; Macromolecular Substances; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction; Spectrophotometry; Substrate Specificity | 1999 |
Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation.
Topics: Amino Acid Sequence; Animals; Arginine; Binding Sites; Biopterins; Conserved Sequence; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Heme; Humans; Mice; Molecular Sequence Data; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Protein Structure, Secondary; Recombinant Proteins; Sequence Homology, Amino Acid; Substrate Specificity | 1999 |
Stoichiometric arginine binding in the oxygenase domain of inducible nitric oxide synthase requires a single molecule of tetrahydrobiopterin per dimer.
Topics: Animals; Arginine; Binding Sites; Biopterins; Carbon Monoxide; Chromatography, Gel; Conserved Sequence; Dimerization; Dithionite; Ferrous Compounds; Heme; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygenases; Protein Binding; Recombinant Proteins; Spectrophotometry, Ultraviolet; Titrimetry | 1999 |
Geminate recombination of nitric oxide to endothelial nitric-oxide synthase and mechanistic implications.
Topics: Arginine; Biopterins; Heme; Humans; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Photolysis; Recombinant Proteins; Spectrum Analysis | 1999 |
Formation of a pterin radical in the reaction of the heme domain of inducible nitric oxide synthase with oxygen.
Topics: Arginine; Biopterins; Electron Spin Resonance Spectroscopy; Free Radicals; Heme; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxygen; Pterins | 1999 |
Structures of the N(omega)-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins.
Topics: Animals; Arginine; Binding Sites; Biopterins; Catalysis; Crystallography, X-Ray; Dimerization; Heme; Hydrogen Bonding; Iron; Mice; Models, Chemical; Models, Molecular; Molecular Sequence Data; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxygen; Oxygenases; Protein Conformation; Structure-Activity Relationship | 2000 |
Aromatic residues and neighboring Arg414 in the (6R)-5,6,7, 8-tetrahydro-L-biopterin binding site of full-length neuronal nitric-oxide synthase are crucial in catalysis and heme reduction with NADPH.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Arginine; Binding Sites; Biopterins; Catalysis; Dimerization; Drosophila; Glutamine; Heme; Humans; Hydrogen Bonding; Leucine; Mice; Models, Molecular; Molecular Sequence Data; NADP; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction; Phenylalanine; Rats; Spectrophotometry, Atomic; Structure-Activity Relationship; Tryptophan | 2000 |
Characterization of interactions among the heme center, tetrahydrobiopterin, and L-arginine binding sites of ferric eNOS using imidazole, cyanide, and nitric oxide as probes.
Topics: Animals; Arginine; Binding, Competitive; Biopterins; Catalysis; Cattle; Computer Simulation; Cyanides; Escherichia coli; Ferric Compounds; Flavins; Genetic Vectors; Heme; Humans; Imidazoles; Ligands; Models, Chemical; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Protein Binding | 2000 |
Arginine conversion to nitroxide by tetrahydrobiopterin-free neuronal nitric-oxide synthase. Implications for mechanism.
Topics: Arginine; Biopterins; Catalysis; Citrulline; Heme; Hydrogen Peroxide; NADP; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxidation-Reduction | 2000 |
Rapid kinetic studies link tetrahydrobiopterin radical formation to heme-dioxy reduction and arginine hydroxylation in inducible nitric-oxide synthase.
Topics: Animals; Arginine; Biopterins; Catalysis; Enzyme Activation; Free Radicals; Heme; Hydroxylation; Kinetics; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidants; Oxidation-Reduction; Oxygen; Oxygenases; Protein Structure, Tertiary; Recombinant Proteins; Reducing Agents; Spectrophotometry | 2001 |
Reconstitution of pterin-free inducible nitric-oxide synthase.
Topics: Animals; Apoenzymes; Biopterins; Cysteine; Glutathione; Heme; Holoenzymes; Mice; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pterins; Spectrophotometry; Zinc | 2001 |
Thiouracil antithyroid drugs as a new class of neuronal nitric oxide synthase inhibitors.
Topics: Animals; Antithyroid Agents; Binding Sites; Binding, Competitive; Biopterins; Cerebellum; Enzyme Inhibitors; Heme; In Vitro Techniques; Models, Biological; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Structure-Activity Relationship; Thiouracil | 2001 |
X-ray absorption spectroscopic analysis of the high-spin ferriheme site in substrate-bound neuronal nitric-oxide synthase.
Topics: Animals; Arginine; Biopterins; Catalytic Domain; Cations, Divalent; Copper; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Heme; Humans; Ligands; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Spectrum Analysis; X-Rays | 2001 |
A conserved tryptophan in nitric oxide synthase regulates heme-dioxy reduction by tetrahydrobiopterin.
Topics: Animals; Arginine; Biopterins; Conserved Sequence; Electron Spin Resonance Spectroscopy; Electrons; Heme; Kinetics; Light; Mice; Models, Chemical; Mutation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxygen; Protein Binding; Spectrophotometry; Time Factors; Tryptophan | 2001 |
Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457.
Topics: Animals; Binding Sites; Biopterins; Catalysis; Conserved Sequence; Crystallography, X-Ray; Dimerization; Electron Transport; Escherichia coli; Heme; Hydrogen Bonding; Mice; Models, Chemical; Models, Molecular; Mutation; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Binding; Recombinant Proteins; Tryptophan | 2001 |
Nitric oxide (NO) traffic in endothelial NO synthase. Evidence for a new NO binding site dependent on tetrahydrobiopterin?
Topics: Arginine; Binding Sites; Biopterins; Dose-Response Relationship, Drug; Heme; Humans; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Protein Binding; Recombinant Proteins; Spectrophotometry; Time Factors | 2002 |
Cloning, expression, and characterization of a nitric oxide synthase protein from Deinococcus radiodurans.
Topics: Amino Acid Sequence; Animals; Arginine; Biopterins; Catalysis; Citrulline; Cloning, Molecular; Dimerization; Dithiothreitol; Dose-Response Relationship, Drug; Electrons; Heme; Hydrogen Peroxide; Kinetics; Ligands; Models, Chemical; Models, Molecular; Molecular Sequence Data; NADP; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Thermus; Time Factors; Zinc | 2002 |
Reactions catalyzed by the heme domain of inducible nitric oxide synthase: evidence for the involvement of tetrahydrobiopterin in electron transfer.
Topics: Arginine; Base Sequence; Biopterins; Catalysis; Chromatography, Gel; DNA Primers; Electron Transport; Heme; Molecular Weight; Nitric Oxide Synthase; Nitric Oxide Synthase Type II | 2002 |
Binding of L-arginine and imidazole suggests heterogeneity of rat brain neuronal nitric oxide synthase.
Topics: Animals; Arginine; Binding, Competitive; Biopterins; Cell Line; Heme; Humans; Imidazoles; Kinetics; Mice; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Spectrophotometry, Ultraviolet; Spodoptera; Titrimetry; Tumor Cells, Cultured | 2002 |
The antithyroid agent 6-n-propyl-2-thiouracil is a mechanism-based inactivator of the neuronal nitric oxide synthase isoform.
Topics: Animals; Antithyroid Agents; Arginine; Biopterins; Calcium; Calmodulin; Carbon Monoxide; Carbon Radioisotopes; Citrulline; Enzyme Activation; Enzyme Inhibitors; Heme; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pituitary Neoplasms; Propylthiouracil; Rats; Thiouracil; Tumor Cells, Cultured | 2002 |
Structure of tetrahydrobiopterin tunes its electron transfer to the heme-dioxy intermediate in nitric oxide synthase.
Topics: Animals; Arginine; Biopterins; Catalysis; Crystallization; Crystallography, X-Ray; Electron Transport; Free Radicals; Heme; Isoenzymes; Kinetics; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Oxygen; Protein Binding; Pterins; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 2003 |
Two modes of binding of N-hydroxyguanidines to NO synthases: first evidence for the formation of iron-N-hydroxyguanidine complexes and key role of tetrahydrobiopterin in determining the binding mode.
Topics: Arginine; Binding Sites; Biopterins; Catalysis; Electron Spin Resonance Spectroscopy; Guanidines; Heme; Hydroxylamines; Iron; Kinetics; Ligands; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxygen; Protein Binding; Spectrum Analysis, Raman; Structure-Activity Relationship | 2003 |
Characterization of Drosophila nitric oxide synthase: a biochemical study.
Topics: Animals; Arginine; Biopterins; Dose-Response Relationship, Drug; Drosophila; Electrons; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Heme; Hydrogen Peroxide; Hydrolysis; NADP; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Open Reading Frames; Protein Structure, Tertiary; Spectrophotometry; Time Factors; Trypsin; Ultraviolet Rays; Urea | 2003 |
Dynamic regulation of the inducible nitric-oxide synthase by NO: comparison with the endothelial isoform.
Topics: Binding Sites; Biopterins; Catalytic Domain; Heme; In Vitro Techniques; Kinetics; Models, Molecular; Mutation; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidation-Reduction; Protein Structure, Tertiary; Recombinant Proteins; Thermodynamics | 2004 |
Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: formation of a pterin radical is required for enzyme activity.
Topics: Amino Acids; Arginine; Binding Sites; Biopterins; Catalysis; Dithionite; Electron Spin Resonance Spectroscopy; Enzyme Activation; Free Radicals; Freezing; Heme; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Oxyhemoglobins; Protein Structure, Tertiary; Pterins; Recombinant Proteins; Time Factors | 2003 |
Three different oxygen-induced radical species in endothelial nitric-oxide synthase oxygenase domain under regulation by L-arginine and tetrahydrobiopterin.
Topics: Amino Acids; Arginine; Biopterins; Catalysis; Cytochromes c; Electron Spin Resonance Spectroscopy; Free Radicals; Heme; Humans; Kinetics; Models, Chemical; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Normal Distribution; Oxygen; Oxygenases; Protein Structure, Tertiary; Proteins; Reactive Oxygen Species; Recombinant Proteins; Spectrophotometry; Superoxides; Time Factors | 2004 |
Analysis of the kinetics of CO binding to neuronal nitric oxide synthase by flash photolysis: dual effects of substrates, inhibitors, and tetrahydrobiopterin.
Topics: Animals; Biopterins; Carbon Monoxide; Enzyme Inhibitors; Heme; Kinetics; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Photolysis; Protein Binding; Protein Structure, Tertiary; Rats | 2004 |
CO exchange of the oxyferrous complexes of endothelial nitric-oxide synthase oxygenase domain in the presence of 4-amino-tetrahydrobiopterin.
Topics: Animals; Biopterins; Carbon Monoxide; Cattle; Ferrous Compounds; Heme; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidation-Reduction; Protein Structure, Tertiary | 2004 |
Redox function of tetrahydrobiopterin and effect of L-arginine on oxygen binding in endothelial nitric oxide synthase.
Topics: Animals; Arginine; Biopterins; Cattle; Ferric Compounds; Ferrous Compounds; Free Radicals; Heme; Humans; Kinetics; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxygen; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Spodoptera; Two-Hybrid System Techniques | 2004 |
The three nitric-oxide synthases differ in their kinetics of tetrahydrobiopterin radical formation, heme-dioxy reduction, and arginine hydroxylation.
Topics: Animals; Arginine; Biopterins; Free Radicals; Heme; Humans; Hydroxylation; Kinetics; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidation-Reduction; Rats | 2005 |
A tryptophan that modulates tetrahydrobiopterin-dependent electron transfer in nitric oxide synthase regulates enzyme catalysis by additional mechanisms.
Topics: Animals; Arginine; Biopterins; Catalysis; Dimerization; Electron Transport; Enzyme Stability; Ferrous Compounds; Heme; Hydroxylation; Isoenzymes; Kinetics; Mice; Mutagenesis, Site-Directed; NADP; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Oxidation-Reduction; Protein Binding; Rats; Spectrophotometry; Tryptophan | 2005 |
Tetrahydrobiopterin depletion and ubiquitylation of neuronal nitric oxide synthase.
Topics: Biopterins; Blotting, Western; Cell Line; Chromatography, High Pressure Liquid; Dimerization; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gene Expression Regulation; Heme; Humans; Hypoxanthines; Immunoprecipitation; Leupeptins; Nitric Oxide Synthase Type I; Pterins; Time Factors; Ubiquitins | 2005 |
Exploring the redox reactions between heme and tetrahydrobiopterin in the nitric oxide synthases.
Topics: Animals; Biochemical Phenomena; Biochemistry; Biopterins; Catalysis; Free Radicals; Heme; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction | 2005 |
Reactivity of the heme-dioxygen complex of the inducible nitric oxide synthase in the presence of alternative substrates.
Topics: Animals; Arginine; Biopterins; Guanidines; Heme; Kinetics; Mice; Models, Chemical; Nitric Oxide Synthase Type II; Oxygen; Substrate Specificity | 2006 |
Dissociation and unfolding of inducible nitric oxide synthase oxygenase domain identifies structural role of tetrahydrobiopterin in modulating the heme environment.
Topics: Animals; Biopterins; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Heme; Indicators and Reagents; Light; Mice; Nitric Oxide Synthase Type II; Protein Conformation; Protein Folding; Protein Structure, Tertiary; Recombinant Proteins; Scattering, Radiation; Spectrophotometry, Ultraviolet; Urea | 2006 |
Regulation of the monomer-dimer equilibrium in inducible nitric-oxide synthase by nitric oxide.
Topics: Amino Acid Motifs; Animals; Arginine; Biopterins; Chelating Agents; Chromatography; Cysteine; Dimerization; Disulfides; Escherichia coli; Heme; Iron; Mass Spectrometry; Mice; Models, Chemical; Models, Molecular; Molecular Conformation; Nitric Oxide; Nitric Oxide Synthase Type II; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Spectrophotometry; Spectrum Analysis, Raman; Structure-Activity Relationship; Sulfhydryl Compounds; Time Factors; Urea; Zinc | 2006 |
The role of tetrahydrobiopterin in catalysis by nitric oxide synthase.
Topics: Algorithms; Arginine; Binding Sites; Biopterins; Catalysis; Electron Transport; Heme; Molecular Structure; Nitric Oxide Synthase; Protons | 2006 |
Oxygenase domain of Drosophila melanogaster nitric oxide synthase: unique kinetic parameters enable a more efficient NO release.
Topics: Animals; Arginine; Biopterins; Buffers; Catalysis; Computer Simulation; Drosophila melanogaster; Edetic Acid; Escherichia coli; Ferrous Compounds; Heme; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Oxygenases; Protein Structure, Tertiary; Spectrophotometry, Ultraviolet; Temperature | 2007 |
Regulation of eNOS-derived superoxide by endogenous methylarginines.
Topics: Arginine; Biopterins; Electron Spin Resonance Spectroscopy; Heme; Humans; NADP; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Superoxides | 2008 |
Stabilization and characterization of a heme-oxy reaction intermediate in inducible nitric-oxide synthase.
Topics: Amino Acid Substitution; Animals; Arginine; Biopterins; Catalytic Domain; Crystallography, X-Ray; Electrochemistry; Free Radicals; Heme; Kinetics; Mice; Mutation, Missense; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidation-Reduction | 2008 |
Comparative computational analysis of active and inactive cofactors of nitric oxide synthase.
Topics: Biopterins; Catalysis; Computational Biology; Electrons; Free Radicals; Heme; Models, Biological; Models, Chemical; Molecular Conformation; Nitric Oxide; Nitric Oxide Synthase; Oxygen; Proteins; Protons; Software | 2009 |
Peroxynitrite induces destruction of the tetrahydrobiopterin and heme in endothelial nitric oxide synthase: transition from reversible to irreversible enzyme inhibition.
Topics: Biopterins; Boranes; Enzyme Stability; Heme; Hemin; Humans; Nitric Oxide Synthase Type III; Peroxynitrous Acid; Protein Binding; Protein Multimerization; Zinc | 2010 |
Spectroscopic, catalytic and binding properties of Bacillus subtilis NO synthase-like protein: comparison with other bacterial and mammalian NO synthases.
Topics: Animals; Arginine; Bacillus subtilis; Bacteria; Bacterial Proteins; Binding Sites; Biocatalysis; Biopterins; Citrulline; Ferric Compounds; Ferrous Compounds; Heme; Hydrogen Peroxide; Imidazoles; Kinetics; Mammals; Nitric Oxide Synthase; Oxidation-Reduction; Protein Binding; Recombinant Proteins; Species Specificity; Spectrophotometry | 2012 |
Tetrahydrobiopterin protects soluble guanylate cyclase against oxidative inactivation.
Topics: Animals; Aorta; Biopterins; Cardiovascular Diseases; Cells, Cultured; Cyclic GMP; Endothelial Cells; Fibroblasts; Guanylate Cyclase; Heme; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Oxidation-Reduction; Oxidative Stress; Peroxynitrous Acid; Pterins; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Superoxides; Swine | 2012 |
Mechanism of inducible nitric-oxide synthase dimerization inhibition by novel pyrimidine imidazoles.
Topics: Amino Acid Substitution; Animals; Arginine; Biopterins; Cell Line; Enzyme Inhibitors; Heme; Imidazoles; Mice; Mutation, Missense; Nitric Oxide Synthase Type II; Protein Multimerization; Pyrimidines | 2013 |
Nitric oxide synthase inhibitors that interact with both heme propionate and tetrahydrobiopterin show high isoform selectivity.
Topics: Biopterins; Enzyme Inhibitors; Heme; Humans; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Structure-Activity Relationship | 2014 |
Tetrahydrobiopterin redox cycling in nitric oxide synthase: evidence supports a through-heme electron delivery.
Topics: Animals; Arginine; Biocatalysis; Biopterins; Electron Spin Resonance Spectroscopy; Electron Transport; Electrons; Free Radicals; Heme; Kinetics; Models, Molecular; Molecular Structure; Mutation; Nitric Oxide Synthase Type I; Oxidation-Reduction; Protein Binding; Protein Domains; Rats | 2016 |
The tetrahydrobiopterin radical interacting with high- and low-spin heme in neuronal nitric oxide synthase - A new indicator of the extent of NOS coupling.
Topics: Animals; Biopterins; Brain Chemistry; Electron Spin Resonance Spectroscopy; Free Radicals; Gene Expression; Heme; Nitric Oxide Synthase Type I; Oxidation-Reduction; Protein Domains; Rats; Recombinant Proteins; Solutions; Temperature | 2016 |