sapogenins and aridanin

Experiments were conducted on different stages of Schistosoma mansoni and S. bovis using various concentrations of aridanin and Aridan. Aridanin and Aridan were active against Schistosoma mansoni and S. bovis miracidia. A low concentration of aridanin (0.25 micrograms/ml) reduced the production of cercariae by snails already shedding cercariae. Aridanin and Aridan also produced profound reduction in the worm recovery of mice infected with pretreated cercariae of S. mansoni and S. bovis. Higher concentrations of the molluscicides were biocidal to the cercariae of these schistosomes. These results indicate that the molluscicides are capable of reducing the transmission of schistosomiasis at different stages of the schistosome development and suggest that a similar effect may occur under field conditions.

Topics: Animals; Mice; Molluscacides; Oleanolic Acid; Plant Extracts; Plants, Medicinal; Sapogenins; Schistosoma; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Snails

The effect of chronic application of sublethal concentrations of aridanin isolated from Tetrapleura tetraptera (0.25-0.125 ppm) and of bayluscide (0.05-0.025 ppm) on the glycogen and protein content of Biomphalaria glabrata was determined. Aridanin and bayluscide produced significant reductions in the glycogen content of B. glabrata, but a significant decrease in the protein content of the snails was not apparent until after 4 weeks of continuous exposure. The results indicate that the molluscicides may exert their primary molluscicidal action on the carbohydrate metabolism of the snail.

Topics: Animals; Biomphalaria; Glycogen; Molluscacides; Niclosamide; Oleanolic Acid; Plant Extracts; Plants, Medicinal; Proteins; Sapogenins

Topics: Animals; Biomphalaria; Calcium Chloride; Glycosides; Magnesium Sulfate; Molluscacides; Oleanolic Acid; Plants; Sapogenins; Serotonin